1. MARKETS
  2. SECTOR : PHARMA & BIOTECH
  3. INDUSTRY : MAJOR PHARMACEUTICALS
  4. ALNYLAM PHARMACEUTICALS INC
Alnylam Pharmaceuticals Inc
XNAS: ALNY
Mid-range Performer
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266.11 1.61 (0.61%)
46.30% Fall from 52W High
1.4M
XNAS Volume

XNAS 04 Sep, 2026 5:30 PM (EDT)

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Board Meeting
The next board meeting for Alnylam Pharma Inc is on 14 Sep 2026 for the purpose of Morgan Stanley 24th Annual Global Healthcare Conference See details


Insider Trading disclosures for Alnylam Pharma Inc

The latest disclosure was made by David E.I. Pyott in Alnylam Pharma Inc where a trade of 3,830 Common Stock done was reported to US exchanges on June 1, 2026.

Insider trading is the trading of a company’s securities by individuals with access to confidential or material non-public information about the company. A company is required to report trading by corporate officers, directors, or other company members with significant access to privileged information to the Securities and Exchange Commission (SEC).

Client Name Client Category Action Reported to Exchange Quantity Post Transaction Holding Traded % Avg. Price Value Security Type
David E.I. Pyott Director Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. 01 Jun 2026 3,830 5,412 (0%) 0% 0 Common Stock
David E.I. Pyott Director Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. 01 Jun 2026 3,830 0 - - Stock Option (Right to Buy)
David E.I. Pyott Director Sale of securities on an exchange or to another person at price $ 302.65 per share. 01 Jun 2026 17 1,582 (0%) 0% 302.6 5,145 Common Stock
David E.I. Pyott Director Sale of securities on an exchange or to another person at price $ 300.72 per share. 01 Jun 2026 495 1,599 (0%) 0% 300.7 148,856 Common Stock
David E.I. Pyott Director Sale of securities on an exchange or to another person at price $ 299.87 per share. 01 Jun 2026 1,222 2,094 (0%) 0% 299.9 366,441 Common Stock
David E.I. Pyott Director Sale of securities on an exchange or to another person at price $ 298.91 per share. 01 Jun 2026 1,175 3,316 (0%) 0% 298.9 351,219 Common Stock
David E.I. Pyott Director Sale of securities on an exchange or to another person at price $ 297.71 per share. 01 Jun 2026 921 4,491 (0%) 0% 297.7 274,191 Common Stock
Elliott Sigal Director Grant, award, or other acquisition of securities at price $ 0.00 per share. 20 May 2026 1,441 1,441 - - Stock Option (Right to Buy)
Elliott Sigal Director Grant, award, or other acquisition of securities at price $ 0.00 per share. 20 May 2026 671 1,446 (0%) 0% 0 Common Stock
Margaret A. Hamburg Director Grant, award, or other acquisition of securities at price $ 0.00 per share. 20 May 2026 671 1,582 (0%) 0% 0 Common Stock
Margaret A. Hamburg Director Grant, award, or other acquisition of securities at price $ 0.00 per share. 20 May 2026 1,441 1,441 - - Stock Option (Right to Buy)
Amy W. Schulman Director Grant, award, or other acquisition of securities at price $ 0.00 per share. 20 May 2026 838 24,049 (0%) 0% 0 Common Stock
Amy W. Schulman Director Grant, award, or other acquisition of securities at price $ 0.00 per share. 20 May 2026 1,802 1,802 - - Stock Option (Right to Buy)
David E.I. Pyott Director Grant, award, or other acquisition of securities at price $ 0.00 per share. 20 May 2026 1,441 1,441 - - Stock Option (Right to Buy)
David E.I. Pyott Director Grant, award, or other acquisition of securities at price $ 0.00 per share. 20 May 2026 671 1,582 (0%) 0% 0 Common Stock
Dennis A. Ausiello Director Grant, award, or other acquisition of securities at price $ 0.00 per share. 20 May 2026 1,441 1,441 - - Stock Option (Right to Buy)
Dennis A. Ausiello Director Grant, award, or other acquisition of securities at price $ 0.00 per share. 20 May 2026 671 1,582 (0%) 0% 0 Common Stock
Peter N. Kellogg Director Grant, award, or other acquisition of securities at price $ 0.00 per share. 20 May 2026 1,441 1,441 - - Stock Option (Right to Buy)
Peter N. Kellogg Director Grant, award, or other acquisition of securities at price $ 0.00 per share. 20 May 2026 671 1,446 (0%) 0% 0 Common Stock
Olivier Raymond Brandicourt Director Grant, award, or other acquisition of securities at price $ 0.00 per share. 20 May 2026 1,441 1,441 - - Stock Option (Right to Buy)
Olivier Raymond Brandicourt Director Grant, award, or other acquisition of securities at price $ 0.00 per share. 20 May 2026 671 1,446 (0%) 0% 0 Common Stock
Stuart A. Arbuckle Director Grant, award, or other acquisition of securities at price $ 0.00 per share. 20 May 2026 1,441 1,441 - - Stock Option (Right to Buy)
Stuart A. Arbuckle Director Grant, award, or other acquisition of securities at price $ 0.00 per share. 20 May 2026 671 671 (0%) 0% 0 Common Stock
Colleen F. Reitan Director Grant, award, or other acquisition of securities at price $ 0.00 per share. 20 May 2026 1,441 1,441 - - Stock Option (Right to Buy)
Colleen F. Reitan Director Grant, award, or other acquisition of securities at price $ 0.00 per share. 20 May 2026 671 1,446 (0%) 0% 0 Common Stock
Amy W. Schulman Director Exercise or conversion of derivative security received from the company (such as an option) at price $ 70.20 per share. 13 May 2026 11,250 23,211 (0%) 0% 70.2 789,750 Common Stock
Amy W. Schulman Director Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. 13 May 2026 11,250 0 - - Stock Option (Right to Buy)
Melissa McLaughlin Chief Human Resources Officer Sale of securities on an exchange or to another person at price $ 316.61 per share. 02 Apr 2026 265 13,088 (0%) 0% 316.6 83,902 Common Stock
Melissa McLaughlin Chief Human Resources Officer Sale of securities on an exchange or to another person at price $ 333.94 per share. 02 Apr 2026 199 9,443 (0%) 0% 333.9 66,454 Common Stock
Melissa McLaughlin Chief Human Resources Officer Sale of securities on an exchange or to another person at price $ 320.14 per share. 02 Apr 2026 56 11,673 (0%) 0% 320.1 17,928 Common Stock
Melissa McLaughlin Chief Human Resources Officer Sale of securities on an exchange or to another person at price $ 323.64 per share. 02 Apr 2026 81 11,737 (0%) 0% 323.6 26,215 Common Stock
Melissa McLaughlin Chief Human Resources Officer Sale of securities on an exchange or to another person at price $ 322.86 per share. 02 Apr 2026 245 11,818 (0%) 0% 322.9 79,101 Common Stock
Melissa McLaughlin Chief Human Resources Officer Sale of securities on an exchange or to another person at price $ 329.76 per share. 02 Apr 2026 909 10,764 (0%) 0% 329.8 299,752 Common Stock
Melissa McLaughlin Chief Human Resources Officer Sale of securities on an exchange or to another person at price $ 330.46 per share. 02 Apr 2026 829 9,935 (0%) 0% 330.5 273,951 Common Stock
Melissa McLaughlin Chief Human Resources Officer Sale of securities on an exchange or to another person at price $ 331.89 per share. 02 Apr 2026 293 9,642 (0%) 0% 331.9 97,244 Common Stock
Melissa McLaughlin Chief Human Resources Officer Sale of securities on an exchange or to another person at price $ 325.50 per share. 02 Apr 2026 8 11,729 (0%) 0% 325.5 2,604 Common Stock
Melissa McLaughlin Chief Human Resources Officer Sale of securities on an exchange or to another person at price $ 321.64 per share. 02 Apr 2026 224 12,063 (0%) 0% 321.6 72,047 Common Stock
Melissa McLaughlin Chief Human Resources Officer Sale of securities on an exchange or to another person at price $ 320.62 per share. 02 Apr 2026 147 12,287 (0%) 0% 320.6 47,131 Common Stock
Melissa McLaughlin Chief Human Resources Officer Sale of securities on an exchange or to another person at price $ 319.69 per share. 02 Apr 2026 86 12,434 (0%) 0% 319.7 27,493 Common Stock
Melissa McLaughlin Chief Human Resources Officer Sale of securities on an exchange or to another person at price $ 318.47 per share. 02 Apr 2026 209 12,520 (0%) 0% 318.5 66,560 Common Stock
Melissa McLaughlin Chief Human Resources Officer Sale of securities on an exchange or to another person at price $ 317.44 per share. 02 Apr 2026 359 12,729 (0%) 0% 317.4 113,961 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 319.03 per share. 04 Mar 2026 135 98,493 (0%) 0% 319.0 43,069 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 325.67 per share. 04 Mar 2026 265 95,695 (0%) 0% 325.7 86,303 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 324.88 per share. 04 Mar 2026 345 95,960 (0%) 0% 324.9 112,084 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 323.84 per share. 04 Mar 2026 973 96,305 (0%) 0% 323.8 315,096 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 323.01 per share. 04 Mar 2026 444 97,278 (0%) 0% 323.0 143,416 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 321.82 per share. 04 Mar 2026 368 97,722 (0%) 0% 321.8 118,430 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 320.81 per share. 04 Mar 2026 274 98,090 (0%) 0% 320.8 87,902 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 320.01 per share. 04 Mar 2026 129 98,364 (0%) 0% 320.0 41,281 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 323.01 per share. 04 Mar 2026 374 63,137 (0%) 0% 323.0 120,806 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 321.82 per share. 04 Mar 2026 309 63,511 (0%) 0% 321.8 99,442 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 319.03 per share. 04 Mar 2026 114 64,159 (0%) 0% 319.0 36,369 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 320.81 per share. 04 Mar 2026 230 63,820 (0%) 0% 320.8 73,786 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 320.01 per share. 04 Mar 2026 109 64,050 (0%) 0% 320.0 34,881 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 325.67 per share. 04 Mar 2026 223 61,805 (0%) 0% 325.7 72,624 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 324.88 per share. 04 Mar 2026 291 62,028 (0%) 0% 324.9 94,540 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 323.84 per share. 04 Mar 2026 818 62,319 (0%) 0% 323.8 264,901 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 323.84 per share. 04 Mar 2026 767 21,577 (0%) 0% 323.8 248,385 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 321.82 per share. 04 Mar 2026 289 22,694 (0%) 0% 321.8 93,006 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 320.81 per share. 04 Mar 2026 215 22,983 (0%) 0% 320.8 68,974 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 320.01 per share. 04 Mar 2026 102 23,198 (0%) 0% 320.0 32,641 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 319.03 per share. 04 Mar 2026 106 23,300 (0%) 0% 319.0 33,817 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 326.08 per share. 04 Mar 2026 500 18,693 (0%) 0% 326.1 163,040 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 324.59 per share. 04 Mar 2026 510 19,193 (0%) 0% 324.6 165,541 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 323.55 per share. 04 Mar 2026 740 19,703 (0%) 0% 323.6 239,427 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 322.33 per share. 04 Mar 2026 654 20,443 (0%) 0% 322.3 210,804 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 325.67 per share. 04 Mar 2026 208 21,097 (0%) 0% 325.7 67,739 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 324.88 per share. 04 Mar 2026 272 21,305 (0%) 0% 324.9 88,367 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 323.01 per share. 04 Mar 2026 350 22,344 (0%) 0% 323.0 113,054 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 325.67 per share. 04 Mar 2026 208 34,297 (0%) 0% 325.7 67,739 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 324.88 per share. 04 Mar 2026 272 34,505 (0%) 0% 324.9 88,367 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 323.84 per share. 04 Mar 2026 767 34,777 (0%) 0% 323.8 248,385 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 323.01 per share. 04 Mar 2026 350 35,544 (0%) 0% 323.0 113,054 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 321.82 per share. 04 Mar 2026 289 35,894 (0%) 0% 321.8 93,006 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 320.81 per share. 04 Mar 2026 215 36,183 (0%) 0% 320.8 68,974 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 320.01 per share. 04 Mar 2026 102 36,398 (0%) 0% 320.0 32,641 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 319.03 per share. 04 Mar 2026 106 36,500 (0%) 0% 319.0 33,817 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 320.81 per share. 04 Mar 2026 59 21,744 (0%) 0% 320.8 18,928 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 326.24 per share. 04 Mar 2026 153 20,569 (0%) 0% 326.2 49,915 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 324.60 per share. 04 Mar 2026 148 20,722 (0%) 0% 324.6 48,041 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 323.25 per share. 04 Mar 2026 233 20,870 (0%) 0% 323.2 75,317 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 321.81 per share. 04 Mar 2026 124 21,103 (0%) 0% 321.8 39,904 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 325.67 per share. 04 Mar 2026 57 21,227 (0%) 0% 325.7 18,563 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 324.88 per share. 04 Mar 2026 75 21,284 (0%) 0% 324.9 24,366 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 323.84 per share. 04 Mar 2026 210 21,359 (0%) 0% 323.8 68,006 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 323.01 per share. 04 Mar 2026 96 21,569 (0%) 0% 323.0 31,009 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 321.82 per share. 04 Mar 2026 79 21,665 (0%) 0% 321.8 25,424 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 320.00 per share. 04 Mar 2026 28 21,803 (0%) 0% 320 8,960 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 319.03 per share. 04 Mar 2026 29 21,831 (0%) 0% 319.0 9,252 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 316.74 per share. 02 Mar 2026 355 24,826 (0%) 0% 316.7 112,443 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 319.06 per share. 02 Mar 2026 317 24,509 (0%) 0% 319.1 101,142 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 320.48 per share. 02 Mar 2026 640 23,869 (0%) 0% 320.5 205,107 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 321.50 per share. 02 Mar 2026 463 23,406 (0%) 0% 321.5 148,855 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 329.71 per share. 02 Mar 2026 170 36,818 (0%) 0% 329.7 56,051 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 328.71 per share. 02 Mar 2026 100 36,988 (0%) 0% 328.7 32,871 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 327.67 per share. 02 Mar 2026 329 37,088 (0%) 0% 327.7 107,803 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 326.81 per share. 02 Mar 2026 392 37,417 (0%) 0% 326.8 128,110 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 325.63 per share. 02 Mar 2026 258 37,809 (0%) 0% 325.6 84,013 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 324.66 per share. 02 Mar 2026 90 38,067 (0%) 0% 324.7 29,219 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 323.62 per share. 02 Mar 2026 47 38,157 (0%) 0% 323.6 15,210 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Grant, award, or other acquisition of securities at price $ 0.00 per share. 02 Mar 2026 4,769 38,204 (0%) 0% 0 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Grant, award, or other acquisition of securities at price $ 0.00 per share. 02 Mar 2026 10,480 10,480 - - Stock Option (right to buy)
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 332.65 per share. 02 Mar 2026 37 36,606 (0%) 0% 332.6 12,308 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 331.93 per share. 02 Mar 2026 94 36,643 (0%) 0% 331.9 31,201 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 330.85 per share. 02 Mar 2026 81 36,737 (0%) 0% 330.9 26,799 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Grant, award, or other acquisition of securities at price $ 0.00 per share. 02 Mar 2026 8,105 8,105 - - Stock Option (right to buy)
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 316.55 per share. 02 Mar 2026 289 23,223 (0%) 0% 316.6 91,483 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 332.65 per share. 02 Mar 2026 37 23,512 (0%) 0% 332.6 12,308 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 331.93 per share. 02 Mar 2026 94 23,549 (0%) 0% 331.9 31,201 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 330.85 per share. 02 Mar 2026 81 23,643 (0%) 0% 330.9 26,799 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 329.71 per share. 02 Mar 2026 170 23,724 (0%) 0% 329.7 56,051 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 328.71 per share. 02 Mar 2026 100 23,894 (0%) 0% 328.7 32,871 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 327.67 per share. 02 Mar 2026 329 23,994 (0%) 0% 327.7 107,803 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 326.81 per share. 02 Mar 2026 392 24,323 (0%) 0% 326.8 128,110 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 325.63 per share. 02 Mar 2026 258 24,715 (0%) 0% 325.6 84,013 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 324.66 per share. 02 Mar 2026 90 24,973 (0%) 0% 324.7 29,219 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 323.62 per share. 02 Mar 2026 47 25,063 (0%) 0% 323.6 15,210 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Grant, award, or other acquisition of securities at price $ 0.00 per share. 02 Mar 2026 3,688 25,110 (0%) 0% 0 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 318.62 per share. 02 Mar 2026 282 22,941 (0%) 0% 318.6 89,851 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 320.51 per share. 02 Mar 2026 722 22,219 (0%) 0% 320.5 231,408 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 321.58 per share. 02 Mar 2026 359 21,860 (0%) 0% 321.6 115,447 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Grant, award, or other acquisition of securities at price $ 0.00 per share. 02 Mar 2026 30,425 30,425 - - Stock Option (right to buy)
Yvonne L Greenstreet Director, Chief Executive Officer Grant, award, or other acquisition of securities at price $ 0.00 per share. 02 Mar 2026 110,746 110,746 - - Stock Price Performance Stock Unit
Yvonne L Greenstreet Director, Chief Executive Officer Grant, award, or other acquisition of securities at price $ 0.00 per share. 02 Mar 2026 13,844 105,427 (0%) 0% 0 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 323.62 per share. 02 Mar 2026 200 105,227 (0%) 0% 323.6 64,724 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 324.65 per share. 02 Mar 2026 382 104,845 (0%) 0% 324.6 124,016 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 325.63 per share. 02 Mar 2026 1,098 103,747 (0%) 0% 325.6 357,542 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 326.81 per share. 02 Mar 2026 1,669 102,078 (0%) 0% 326.8 545,446 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 327.67 per share. 02 Mar 2026 1,399 100,679 (0%) 0% 327.7 458,410 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 328.71 per share. 02 Mar 2026 424 100,255 (0%) 0% 328.7 139,373 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 329.71 per share. 02 Mar 2026 722 99,533 (0%) 0% 329.7 238,051 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 330.85 per share. 02 Mar 2026 346 99,187 (0%) 0% 330.8 114,474 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 331.93 per share. 02 Mar 2026 399 98,788 (0%) 0% 331.9 132,440 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 332.64 per share. 02 Mar 2026 160 98,628 (0%) 0% 332.6 53,222 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 332.64 per share. 02 Mar 2026 53 64,273 (0%) 0% 332.6 17,630 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 330.85 per share. 02 Mar 2026 112 64,455 (0%) 0% 330.8 37,055 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Grant, award, or other acquisition of securities at price $ 0.00 per share. 02 Mar 2026 4,769 66,479 (0%) 0% 0 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 323.62 per share. 02 Mar 2026 65 66,414 (0%) 0% 323.6 21,035 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 324.65 per share. 02 Mar 2026 124 66,290 (0%) 0% 324.7 40,257 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 325.63 per share. 02 Mar 2026 356 65,934 (0%) 0% 325.6 115,924 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 326.81 per share. 02 Mar 2026 541 65,393 (0%) 0% 326.8 176,804 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 327.67 per share. 02 Mar 2026 454 64,939 (0%) 0% 327.7 148,762 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 328.71 per share. 02 Mar 2026 138 64,801 (0%) 0% 328.7 45,362 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 329.71 per share. 02 Mar 2026 234 64,567 (0%) 0% 329.7 77,152 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Grant, award, or other acquisition of securities at price $ 0.00 per share. 02 Mar 2026 10,480 10,480 - - Stock Option (right to buy)
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 331.93 per share. 02 Mar 2026 129 64,326 (0%) 0% 331.9 42,819 Common Stock
Pushkal P. Garg EVP Chief R&D Grant, award, or other acquisition of securities at price $ 0.00 per share. 02 Mar 2026 10,480 10,480 - - Stock Option (right to buy)
Pushkal P. Garg EVP Chief R&D Grant, award, or other acquisition of securities at price $ 0.00 per share. 02 Mar 2026 4,769 26,898 (0%) 0% 0 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 323.62 per share. 02 Mar 2026 50 26,848 (0%) 0% 323.6 16,181 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 324.65 per share. 02 Mar 2026 97 26,751 (0%) 0% 324.6 31,491 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 325.63 per share. 02 Mar 2026 277 26,474 (0%) 0% 325.6 90,200 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 326.81 per share. 02 Mar 2026 421 26,053 (0%) 0% 326.8 137,587 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 327.67 per share. 02 Mar 2026 353 25,700 (0%) 0% 327.7 115,668 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 328.71 per share. 02 Mar 2026 107 25,593 (0%) 0% 328.7 35,172 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 329.71 per share. 02 Mar 2026 182 25,411 (0%) 0% 329.7 60,007 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 330.85 per share. 02 Mar 2026 87 25,324 (0%) 0% 330.9 28,784 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 331.93 per share. 02 Mar 2026 101 25,223 (0%) 0% 331.9 33,525 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 332.64 per share. 02 Mar 2026 42 25,181 (0%) 0% 332.6 13,971 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. 27 Feb 2026 5,921 91,583 (0%) 0% 0 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. 27 Feb 2026 5,921 0 - - Restricted Stock Units
Jeffrey V. Poulton EVP, Chief Financial Officer Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. 27 Feb 2026 1,908 61,710 (0%) 0% 0 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. 27 Feb 2026 1,908 0 - - Restricted Stock Units
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 328.92 per share. 27 Feb 2026 127 26,629 (0%) 0% 328.9 41,773 Common Stock
Pushkal P. Garg EVP Chief R&D Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. 27 Feb 2026 1,908 0 - - Restricted Stock Units
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 334.39 per share. 27 Feb 2026 140 22,129 (0%) 0% 334.4 46,815 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 332.48 per share. 27 Feb 2026 942 22,269 (0%) 0% 332.5 313,196 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 331.49 per share. 27 Feb 2026 1,159 23,211 (0%) 0% 331.5 384,197 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 330.73 per share. 27 Feb 2026 2,259 24,370 (0%) 0% 330.7 747,119 Common Stock
Pushkal P. Garg EVP Chief R&D Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. 27 Feb 2026 1,908 26,756 (0%) 0% 0 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. 27 Feb 2026 1,666 0 - - Restricted Stock Units
Tolga Tanguler EVP, Chief Commercial Officer Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. 27 Feb 2026 1,666 33,435 (0%) 0% 0 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Grant, award, or other acquisition of securities at price $ 0.00 per share. 23 Feb 2026 158 21,422 (0%) 0% 0 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Grant, award, or other acquisition of securities at price $ 0.00 per share. 12 Feb 2026 14,209 92,620 (0%) 0% 0 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 310.08 per share. 12 Feb 2026 6,958 85,662 (0%) 0% 310.1 2,157,542 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Grant, award, or other acquisition of securities at price $ 0.00 per share. 12 Feb 2026 4,579 62,044 (0%) 0% 0 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 310.08 per share. 12 Feb 2026 2,242 59,802 (0%) 0% 310.1 695,201 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 310.08 per share. 12 Feb 2026 2,242 24,848 (0%) 0% 310.1 695,201 Common Stock
Pushkal P. Garg EVP Chief R&D Grant, award, or other acquisition of securities at price $ 0.00 per share. 12 Feb 2026 4,579 27,090 (0%) 0% 0 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 310.08 per share. 12 Feb 2026 1,959 31,769 (0%) 0% 310.1 607,448 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Grant, award, or other acquisition of securities at price $ 0.00 per share. 12 Feb 2026 4,000 33,728 (0%) 0% 0 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 331.96 per share. 12 Feb 2026 2,041 21,264 (0%) 0% 332.0 677,532 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Grant, award, or other acquisition of securities at price $ 0.00 per share. 12 Feb 2026 4,000 25,264 (0%) 0% 0 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 310.08 per share. 12 Feb 2026 1,959 23,305 (0%) 0% 310.1 607,448 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Grant, award, or other acquisition of securities at price $ 0.00 per share. 11 Jan 2026 19,003 87,988 (0%) 0% 0 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 377.82 per share. 11 Jan 2026 94 78,411 (0%) 0% 377.8 35,515 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 375.65 per share. 11 Jan 2026 118 78,505 (0%) 0% 375.7 44,327 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 374.44 per share. 11 Jan 2026 88 78,623 (0%) 0% 374.4 32,951 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 372.48 per share. 11 Jan 2026 21 78,711 (0%) 0% 372.5 7,822 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 370.87 per share. 11 Jan 2026 118 78,732 (0%) 0% 370.9 43,763 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 369.48 per share. 11 Jan 2026 253 78,850 (0%) 0% 369.5 93,478 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 368.62 per share. 11 Jan 2026 584 79,103 (0%) 0% 368.6 215,274 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 367.40 per share. 11 Jan 2026 261 79,687 (0%) 0% 367.4 95,891 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 366.41 per share. 11 Jan 2026 316 79,948 (0%) 0% 366.4 115,786 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 365.56 per share. 11 Jan 2026 1,395 80,264 (0%) 0% 365.6 509,956 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 364.83 per share. 11 Jan 2026 1,259 81,659 (0%) 0% 364.8 459,321 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 363.55 per share. 11 Jan 2026 301 82,918 (0%) 0% 363.6 109,429 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 362.38 per share. 11 Jan 2026 464 83,219 (0%) 0% 362.4 168,144 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 361.45 per share. 11 Jan 2026 624 83,683 (0%) 0% 361.5 225,545 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 360.22 per share. 11 Jan 2026 980 84,307 (0%) 0% 360.2 353,016 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 359.14 per share. 11 Jan 2026 537 85,287 (0%) 0% 359.1 192,858 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 358.18 per share. 11 Jan 2026 778 85,824 (0%) 0% 358.2 278,664 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 357.17 per share. 11 Jan 2026 607 86,602 (0%) 0% 357.2 216,802 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 356.09 per share. 11 Jan 2026 263 87,209 (0%) 0% 356.1 93,652 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 355.16 per share. 11 Jan 2026 269 87,472 (0%) 0% 355.2 95,538 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 353.95 per share. 11 Jan 2026 247 87,741 (0%) 0% 354.0 87,426 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Grant, award, or other acquisition of securities at price $ 0.00 per share. 11 Jan 2026 6,193 60,245 (0%) 0% 0 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 353.94 per share. 11 Jan 2026 72 60,173 (0%) 0% 353.9 25,484 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 355.15 per share. 11 Jan 2026 78 60,095 (0%) 0% 355.2 27,702 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 356.09 per share. 11 Jan 2026 76 60,019 (0%) 0% 356.1 27,063 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 357.17 per share. 11 Jan 2026 176 59,843 (0%) 0% 357.2 62,862 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 358.18 per share. 11 Jan 2026 226 59,617 (0%) 0% 358.2 80,949 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 359.14 per share. 11 Jan 2026 156 59,461 (0%) 0% 359.1 56,026 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 360.22 per share. 11 Jan 2026 284 59,177 (0%) 0% 360.2 102,302 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 361.45 per share. 11 Jan 2026 181 58,996 (0%) 0% 361.4 65,422 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 362.38 per share. 11 Jan 2026 135 58,861 (0%) 0% 362.4 48,921 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 363.55 per share. 11 Jan 2026 87 58,774 (0%) 0% 363.6 31,629 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 364.83 per share. 11 Jan 2026 365 58,409 (0%) 0% 364.8 133,163 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 365.56 per share. 11 Jan 2026 405 58,004 (0%) 0% 365.6 148,052 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 366.41 per share. 11 Jan 2026 92 57,912 (0%) 0% 366.4 33,710 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 367.39 per share. 11 Jan 2026 76 57,836 (0%) 0% 367.4 27,922 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 368.62 per share. 11 Jan 2026 170 57,666 (0%) 0% 368.6 62,665 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 369.48 per share. 11 Jan 2026 73 57,593 (0%) 0% 369.5 26,972 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 370.86 per share. 11 Jan 2026 36 57,557 (0%) 0% 370.9 13,351 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 372.50 per share. 11 Jan 2026 6 57,551 (0%) 0% 372.5 2,235 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 374.44 per share. 11 Jan 2026 25 57,526 (0%) 0% 374.4 9,361 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 375.65 per share. 11 Jan 2026 34 57,492 (0%) 0% 375.6 12,772 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 377.81 per share. 11 Jan 2026 27 57,465 (0%) 0% 377.8 10,201 Common Stock
Pushkal P. Garg EVP Chief R&D Grant, award, or other acquisition of securities at price $ 0.00 per share. 11 Jan 2026 3,800 24,021 (0%) 0% 0 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 353.95 per share. 11 Jan 2026 39 23,982 (0%) 0% 353.9 13,804 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 355.17 per share. 11 Jan 2026 42 23,940 (0%) 0% 355.2 14,917 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 356.10 per share. 11 Jan 2026 41 23,899 (0%) 0% 356.1 14,600 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 357.17 per share. 11 Jan 2026 96 23,803 (0%) 0% 357.2 34,288 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 358.18 per share. 11 Jan 2026 123 23,680 (0%) 0% 358.2 44,056 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 359.14 per share. 11 Jan 2026 85 23,595 (0%) 0% 359.1 30,527 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 360.22 per share. 11 Jan 2026 155 23,440 (0%) 0% 360.2 55,834 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 361.45 per share. 11 Jan 2026 98 23,342 (0%) 0% 361.4 35,422 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 362.38 per share. 11 Jan 2026 73 23,269 (0%) 0% 362.4 26,454 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 363.55 per share. 11 Jan 2026 47 23,222 (0%) 0% 363.6 17,087 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 364.83 per share. 11 Jan 2026 199 23,023 (0%) 0% 364.8 72,601 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 365.56 per share. 11 Jan 2026 220 22,803 (0%) 0% 365.6 80,423 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 366.42 per share. 11 Jan 2026 50 22,753 (0%) 0% 366.4 18,321 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 367.39 per share. 11 Jan 2026 41 22,712 (0%) 0% 367.4 15,063 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 368.62 per share. 11 Jan 2026 92 22,620 (0%) 0% 368.6 33,913 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 369.48 per share. 11 Jan 2026 40 22,580 (0%) 0% 369.5 14,779 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 370.89 per share. 11 Jan 2026 18 22,562 (0%) 0% 370.9 6,676 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 372.33 per share. 11 Jan 2026 3 22,559 (0%) 0% 372.3 1,117 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 374.43 per share. 11 Jan 2026 14 22,545 (0%) 0% 374.4 5,242 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 375.63 per share. 11 Jan 2026 19 22,526 (0%) 0% 375.6 7,137 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 377.80 per share. 11 Jan 2026 15 22,511 (0%) 0% 377.8 5,667 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 358.18 per share. 11 Jan 2026 123 30,897 (0%) 0% 358.2 44,056 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 377.80 per share. 11 Jan 2026 15 29,728 (0%) 0% 377.8 5,667 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Grant, award, or other acquisition of securities at price $ 0.00 per share. 11 Jan 2026 3,800 31,238 (0%) 0% 0 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 353.95 per share. 11 Jan 2026 39 31,199 (0%) 0% 353.9 13,804 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 355.17 per share. 11 Jan 2026 42 31,157 (0%) 0% 355.2 14,917 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 356.10 per share. 11 Jan 2026 41 31,116 (0%) 0% 356.1 14,600 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 357.17 per share. 11 Jan 2026 96 31,020 (0%) 0% 357.2 34,288 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 359.14 per share. 11 Jan 2026 85 30,812 (0%) 0% 359.1 30,527 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 360.22 per share. 11 Jan 2026 155 30,657 (0%) 0% 360.2 55,834 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 361.45 per share. 11 Jan 2026 98 30,559 (0%) 0% 361.4 35,422 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 362.38 per share. 11 Jan 2026 73 30,486 (0%) 0% 362.4 26,454 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 363.55 per share. 11 Jan 2026 47 30,439 (0%) 0% 363.6 17,087 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 364.83 per share. 11 Jan 2026 199 30,240 (0%) 0% 364.8 72,601 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 365.56 per share. 11 Jan 2026 220 30,020 (0%) 0% 365.6 80,423 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 366.42 per share. 11 Jan 2026 50 29,970 (0%) 0% 366.4 18,321 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 367.39 per share. 11 Jan 2026 41 29,929 (0%) 0% 367.4 15,063 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 368.62 per share. 11 Jan 2026 92 29,837 (0%) 0% 368.6 33,913 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 369.48 per share. 11 Jan 2026 40 29,797 (0%) 0% 369.5 14,779 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 370.89 per share. 11 Jan 2026 19 29,778 (0%) 0% 370.9 7,047 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 372.50 per share. 11 Jan 2026 2 29,776 (0%) 0% 372.5 745 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 374.43 per share. 11 Jan 2026 14 29,762 (0%) 0% 374.4 5,242 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 375.63 per share. 11 Jan 2026 19 29,743 (0%) 0% 375.6 7,137 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 364.83 per share. 11 Jan 2026 199 24,066 (0%) 0% 364.8 72,601 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 363.55 per share. 11 Jan 2026 47 24,265 (0%) 0% 363.6 17,087 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 362.38 per share. 11 Jan 2026 73 24,312 (0%) 0% 362.4 26,454 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 361.45 per share. 11 Jan 2026 98 24,385 (0%) 0% 361.4 35,422 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 360.22 per share. 11 Jan 2026 155 24,483 (0%) 0% 360.2 55,834 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 359.14 per share. 11 Jan 2026 85 24,638 (0%) 0% 359.1 30,527 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 370.00 per share. 11 Jan 2026 644 22,151 (0%) 0% 370 238,280 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 371.24 per share. 11 Jan 2026 485 21,666 (0%) 0% 371.2 180,051 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 357.17 per share. 11 Jan 2026 96 24,846 (0%) 0% 357.2 34,288 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 356.10 per share. 11 Jan 2026 41 24,942 (0%) 0% 356.1 14,600 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 355.17 per share. 11 Jan 2026 42 24,983 (0%) 0% 355.2 14,917 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 353.95 per share. 11 Jan 2026 39 25,025 (0%) 0% 353.9 13,804 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Grant, award, or other acquisition of securities at price $ 0.00 per share. 11 Jan 2026 3,800 25,064 (0%) 0% 0 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 372.93 per share. 11 Jan 2026 280 21,386 (0%) 0% 372.9 104,420 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 374.33 per share. 11 Jan 2026 122 21,264 (0%) 0% 374.3 45,668 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 368.76 per share. 11 Jan 2026 562 22,795 (0%) 0% 368.8 207,243 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 367.52 per share. 11 Jan 2026 197 23,357 (0%) 0% 367.5 72,401 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 377.80 per share. 11 Jan 2026 15 23,554 (0%) 0% 377.8 5,667 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 358.18 per share. 11 Jan 2026 123 24,723 (0%) 0% 358.2 44,056 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 375.63 per share. 11 Jan 2026 19 23,569 (0%) 0% 375.6 7,137 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 374.43 per share. 11 Jan 2026 14 23,588 (0%) 0% 374.4 5,242 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 372.50 per share. 11 Jan 2026 2 23,602 (0%) 0% 372.5 745 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 370.89 per share. 11 Jan 2026 19 23,604 (0%) 0% 370.9 7,047 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 369.48 per share. 11 Jan 2026 40 23,623 (0%) 0% 369.5 14,779 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 368.62 per share. 11 Jan 2026 92 23,663 (0%) 0% 368.6 33,913 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 367.39 per share. 11 Jan 2026 41 23,755 (0%) 0% 367.4 15,063 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 366.42 per share. 11 Jan 2026 50 23,796 (0%) 0% 366.4 18,321 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 365.56 per share. 11 Jan 2026 220 23,846 (0%) 0% 365.6 80,423 Common Stock
Stuart A. Arbuckle Director Grant, award, or other acquisition of securities at price $ 0.00 per share. 05 Jan 2026 3,279 3,279 - - Stock Option (right to buy)
Yvonne L Greenstreet Director, Chief Executive Officer Exercise or conversion of derivative security received from the company (such as an option) at price $ 119.13 per share. 26 Nov 2025 839 66,248 (0%) 0% 119.1 99,950 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Exercise or conversion of derivative security received from the company (such as an option) at price $ 85.00 per share. 26 Nov 2025 2,352 68,600 (0%) 0% 85 199,920 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Exercise or conversion of derivative security received from the company (such as an option) at price $ 118.05 per share. 26 Nov 2025 847 69,447 (0%) 0% 118.0 99,988 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Exercise or conversion of derivative security received from the company (such as an option) at price $ 151.59 per share. 26 Nov 2025 659 70,106 (0%) 0% 151.6 99,898 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Payment of exercise price or tax liability using portion of securities received from the company at price $ 445.12 per share. 26 Nov 2025 1,121 68,985 (0%) 0% 445.1 498,980 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. 26 Nov 2025 2,352 0 - - Stock Option (right to buy)
Yvonne L Greenstreet Director, Chief Executive Officer Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. 26 Nov 2025 847 0 - - Stock Option (right to buy)
Yvonne L Greenstreet Director, Chief Executive Officer Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. 26 Nov 2025 839 0 - - Stock Option (right to buy)
Yvonne L Greenstreet Director, Chief Executive Officer Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. 26 Nov 2025 659 28,141 - - Stock Option (right to buy)
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. 17 Nov 2025 8,161 839 - - Stock Option (right to buy)
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 463.08 per share. 17 Nov 2025 295 21,264 (0%) 0% 463.1 136,609 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 461.96 per share. 17 Nov 2025 323 21,559 (0%) 0% 462.0 149,213 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 460.84 per share. 17 Nov 2025 707 21,882 (0%) 0% 460.8 325,814 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 459.89 per share. 17 Nov 2025 622 22,589 (0%) 0% 459.9 286,052 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 458.41 per share. 17 Nov 2025 794 23,211 (0%) 0% 458.4 363,978 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 457.39 per share. 17 Nov 2025 262 24,005 (0%) 0% 457.4 119,836 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 456.25 per share. 17 Nov 2025 364 24,267 (0%) 0% 456.3 166,075 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 455.24 per share. 17 Nov 2025 368 24,631 (0%) 0% 455.2 167,528 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 451.51 per share. 17 Nov 2025 129 24,999 (0%) 0% 451.5 58,245 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 450.09 per share. 17 Nov 2025 96 25,128 (0%) 0% 450.1 43,209 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 449.00 per share. 17 Nov 2025 8,168 25,224 (0%) 0% 449 3,667,432 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Exercise or conversion of derivative security received from the company (such as an option) at price $ 119.13 per share. 17 Nov 2025 8,161 33,392 (0%) 0% 119.1 972,220 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 447.73 per share. 12 Nov 2025 654 74,755 (0%) 0% 447.7 292,815 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Exercise or conversion of derivative security received from the company (such as an option) at price $ 119.13 per share. 12 Nov 2025 15,000 81,059 (0%) 0% 119.1 1,786,950 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Exercise or conversion of derivative security received from the company (such as an option) at price $ 42.22 per share. 12 Nov 2025 650 66,059 (0%) 0% 42.2 27,443 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. 12 Nov 2025 10,000 0 - - Performance Stock Option 2017 (right to buy)
Yvonne L Greenstreet Director, Chief Executive Officer Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. 12 Nov 2025 15,000 10,000 - - Performance Stock Option 2017 (right to buy)
Yvonne L Greenstreet Director, Chief Executive Officer Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. 12 Nov 2025 650 0 - - Performance Stock Option 2016 (right to buy)
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 456.03 per share. 12 Nov 2025 261 65,409 (0%) 0% 456.0 119,024 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 454.69 per share. 12 Nov 2025 195 65,670 (0%) 0% 454.7 88,665 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 453.99 per share. 12 Nov 2025 881 65,865 (0%) 0% 454.0 399,965 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 452.85 per share. 12 Nov 2025 1,599 66,746 (0%) 0% 452.8 724,107 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 451.94 per share. 12 Nov 2025 1,702 68,345 (0%) 0% 451.9 769,202 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 450.69 per share. 12 Nov 2025 2,218 70,047 (0%) 0% 450.7 999,630 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 450.02 per share. 12 Nov 2025 1,477 72,265 (0%) 0% 450.0 664,680 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 448.76 per share. 12 Nov 2025 1,013 73,742 (0%) 0% 448.8 454,594 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Exercise or conversion of derivative security received from the company (such as an option) at price $ 119.13 per share. 12 Nov 2025 10,000 75,409 (0%) 0% 119.1 1,191,300 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 458.42 per share. 12 Nov 2025 430 65,409 (0%) 0% 458.4 197,121 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 457.71 per share. 12 Nov 2025 604 65,839 (0%) 0% 457.7 276,457 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 456.64 per share. 12 Nov 2025 2,420 66,443 (0%) 0% 456.6 1,105,069 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 455.56 per share. 12 Nov 2025 3,406 68,863 (0%) 0% 455.6 1,551,637 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 454.84 per share. 12 Nov 2025 1,960 72,269 (0%) 0% 454.8 891,486 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 453.52 per share. 12 Nov 2025 1,069 74,229 (0%) 0% 453.5 484,813 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 452.43 per share. 12 Nov 2025 1,210 75,298 (0%) 0% 452.4 547,440 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 451.16 per share. 12 Nov 2025 1,255 76,508 (0%) 0% 451.2 566,206 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 450.17 per share. 12 Nov 2025 453 77,763 (0%) 0% 450.2 203,927 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 449.15 per share. 12 Nov 2025 2,132 78,216 (0%) 0% 449.2 957,588 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 448.07 per share. 12 Nov 2025 711 80,348 (0%) 0% 448.1 318,578 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Grant, award, or other acquisition of securities at price $ 0.00 per share. 01 Oct 2025 3,860 60,081 (0%) 0% 0 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 457.67 per share. 01 Oct 2025 9 65,409 (0%) 0% 457.7 4,119 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 457.43 per share. 01 Oct 2025 446 65,418 (0%) 0% 457.4 204,014 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 455.82 per share. 01 Oct 2025 221 65,864 (0%) 0% 455.8 100,736 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 454.84 per share. 01 Oct 2025 741 66,085 (0%) 0% 454.8 337,036 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 453.77 per share. 01 Oct 2025 999 66,826 (0%) 0% 453.8 453,316 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 452.69 per share. 01 Oct 2025 2,029 67,825 (0%) 0% 452.7 918,508 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 451.86 per share. 01 Oct 2025 1,010 69,854 (0%) 0% 451.9 456,379 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 450.81 per share. 01 Oct 2025 1,642 70,864 (0%) 0% 450.8 740,230 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 449.79 per share. 01 Oct 2025 758 72,506 (0%) 0% 449.8 340,941 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 448.77 per share. 01 Oct 2025 548 73,264 (0%) 0% 448.8 245,926 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 447.92 per share. 01 Oct 2025 171 73,812 (0%) 0% 447.9 76,594 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 446.53 per share. 01 Oct 2025 350 73,983 (0%) 0% 446.5 156,286 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Grant, award, or other acquisition of securities at price $ 0.00 per share. 01 Oct 2025 14,252 74,333 (0%) 0% 0 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Grant, award, or other acquisition of securities at price $ 0.00 per share. 01 Oct 2025 3,108 53,229 (0%) 0% 0 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 457.43 per share. 01 Oct 2025 191 54,056 (0%) 0% 457.4 87,369 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Grant, award, or other acquisition of securities at price $ 0.00 per share. 01 Oct 2025 4,644 57,873 (0%) 0% 0 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 446.53 per share. 01 Oct 2025 150 57,723 (0%) 0% 446.5 66,980 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 447.92 per share. 01 Oct 2025 73 57,650 (0%) 0% 447.9 32,698 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 448.77 per share. 01 Oct 2025 234 57,416 (0%) 0% 448.8 105,012 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 449.79 per share. 01 Oct 2025 324 57,092 (0%) 0% 449.8 145,732 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 457.75 per share. 01 Oct 2025 4 54,052 (0%) 0% 457.8 1,831 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 450.81 per share. 01 Oct 2025 704 56,388 (0%) 0% 450.8 317,370 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 451.86 per share. 01 Oct 2025 432 55,956 (0%) 0% 451.9 195,204 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 452.69 per share. 01 Oct 2025 869 55,087 (0%) 0% 452.7 393,388 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 453.77 per share. 01 Oct 2025 428 54,659 (0%) 0% 453.8 194,214 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 454.84 per share. 01 Oct 2025 317 54,342 (0%) 0% 454.8 144,184 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 455.82 per share. 01 Oct 2025 95 54,247 (0%) 0% 455.8 43,303 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 451.86 per share. 01 Oct 2025 332 24,707 (0%) 0% 451.9 150,018 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 449.99 per share. 01 Oct 2025 682 22,561 (0%) 0% 450.0 306,893 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 457.67 per share. 01 Oct 2025 3 23,243 (0%) 0% 457.7 1,373 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 457.43 per share. 01 Oct 2025 147 23,246 (0%) 0% 457.4 67,242 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 455.82 per share. 01 Oct 2025 73 23,393 (0%) 0% 455.8 33,275 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 454.84 per share. 01 Oct 2025 244 23,466 (0%) 0% 454.8 110,981 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 453.77 per share. 01 Oct 2025 329 23,710 (0%) 0% 453.8 149,290 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 452.69 per share. 01 Oct 2025 668 24,039 (0%) 0% 452.7 302,397 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 450.63 per share. 01 Oct 2025 810 21,751 (0%) 0% 450.6 365,010 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 450.81 per share. 01 Oct 2025 541 25,039 (0%) 0% 450.8 243,888 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 449.79 per share. 01 Oct 2025 249 25,580 (0%) 0% 449.8 111,998 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 448.77 per share. 01 Oct 2025 180 25,829 (0%) 0% 448.8 80,779 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 447.93 per share. 01 Oct 2025 56 26,009 (0%) 0% 447.9 25,084 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 446.53 per share. 01 Oct 2025 115 26,065 (0%) 0% 446.5 51,351 Common Stock
Pushkal P. Garg EVP Chief R&D Grant, award, or other acquisition of securities at price $ 0.00 per share. 01 Oct 2025 2,851 26,180 (0%) 0% 0 Common Stock
Pushkal P. Garg EVP Chief R&D Grant, award, or other acquisition of securities at price $ 0.00 per share. 01 Oct 2025 3,108 23,329 (0%) 0% 0 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 454.37 per share. 01 Oct 2025 215 20,221 (0%) 0% 454.4 97,690 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 453.51 per share. 01 Oct 2025 417 20,436 (0%) 0% 453.5 189,114 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 451.76 per share. 01 Oct 2025 898 20,853 (0%) 0% 451.8 405,680 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 451.86 per share. 01 Oct 2025 159 28,137 (0%) 0% 451.9 71,846 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 458.00 per share. 01 Oct 2025 1 27,438 (0%) 0% 458 458 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 452.69 per share. 01 Oct 2025 319 27,818 (0%) 0% 452.7 144,408 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 453.77 per share. 01 Oct 2025 157 27,661 (0%) 0% 453.8 71,242 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 454.84 per share. 01 Oct 2025 117 27,544 (0%) 0% 454.8 53,216 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 455.83 per share. 01 Oct 2025 35 27,509 (0%) 0% 455.8 15,954 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 457.43 per share. 01 Oct 2025 70 27,439 (0%) 0% 457.4 32,020 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Grant, award, or other acquisition of securities at price $ 0.00 per share. 01 Oct 2025 2,851 28,843 (0%) 0% 0 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 446.53 per share. 01 Oct 2025 55 28,788 (0%) 0% 446.5 24,559 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 447.93 per share. 01 Oct 2025 27 28,761 (0%) 0% 447.9 12,094 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 448.77 per share. 01 Oct 2025 86 28,675 (0%) 0% 448.8 38,594 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 449.79 per share. 01 Oct 2025 119 28,556 (0%) 0% 449.8 53,525 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 450.81 per share. 01 Oct 2025 260 28,296 (0%) 0% 450.8 117,211 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Grant, award, or other acquisition of securities at price $ 0.00 per share. 01 Oct 2025 2,102 24,821 (0%) 0% 0 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 457.67 per share. 01 Oct 2025 3 25,231 (0%) 0% 457.7 1,373 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 457.43 per share. 01 Oct 2025 122 25,234 (0%) 0% 457.4 55,806 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 455.82 per share. 01 Oct 2025 60 25,356 (0%) 0% 455.8 27,349 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 454.84 per share. 01 Oct 2025 203 25,416 (0%) 0% 454.8 92,333 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 453.77 per share. 01 Oct 2025 273 25,619 (0%) 0% 453.8 123,879 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 452.69 per share. 01 Oct 2025 555 25,892 (0%) 0% 452.7 251,243 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 451.86 per share. 01 Oct 2025 276 26,447 (0%) 0% 451.9 124,713 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 450.81 per share. 01 Oct 2025 449 26,723 (0%) 0% 450.8 202,414 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 449.79 per share. 01 Oct 2025 207 27,172 (0%) 0% 449.8 93,107 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 448.77 per share. 01 Oct 2025 150 27,379 (0%) 0% 448.8 67,316 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 447.91 per share. 01 Oct 2025 47 27,529 (0%) 0% 447.9 21,052 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 446.53 per share. 01 Oct 2025 96 27,576 (0%) 0% 446.5 42,867 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Grant, award, or other acquisition of securities at price $ 0.00 per share. 01 Oct 2025 2,851 27,672 (0%) 0% 0 Common Stock
Colleen F. Reitan Director Sale of securities on an exchange or to another person at price $ 460.71 per share. 09 Sep 2025 473 13,366 (0%) 0% 460.7 217,916 Common Stock
Colleen F. Reitan Director Sale of securities on an exchange or to another person at price $ 461.92 per share. 09 Sep 2025 2,290 11,076 (0%) 0% 461.9 1,057,797 Common Stock
Colleen F. Reitan Director Sale of securities on an exchange or to another person at price $ 463.00 per share. 09 Sep 2025 1,652 9,424 (0%) 0% 463 764,876 Common Stock
Colleen F. Reitan Director Sale of securities on an exchange or to another person at price $ 464.36 per share. 09 Sep 2025 799 8,625 (0%) 0% 464.4 371,024 Common Stock
Colleen F. Reitan Director Sale of securities on an exchange or to another person at price $ 471.25 per share. 09 Sep 2025 222 8,403 (0%) 0% 471.3 104,618 Common Stock
Colleen F. Reitan Director Sale of securities on an exchange or to another person at price $ 472.82 per share. 09 Sep 2025 823 7,580 (0%) 0% 472.8 389,131 Common Stock
Colleen F. Reitan Director Sale of securities on an exchange or to another person at price $ 474.22 per share. 09 Sep 2025 838 6,742 (0%) 0% 474.2 397,396 Common Stock
Colleen F. Reitan Director Sale of securities on an exchange or to another person at price $ 474.85 per share. 09 Sep 2025 951 5,791 (0%) 0% 474.8 451,582 Common Stock
Colleen F. Reitan Director Sale of securities on an exchange or to another person at price $ 476.31 per share. 09 Sep 2025 972 4,819 (0%) 0% 476.3 462,973 Common Stock
Colleen F. Reitan Director Sale of securities on an exchange or to another person at price $ 477.47 per share. 09 Sep 2025 1,183 3,636 (0%) 0% 477.5 564,847 Common Stock
Colleen F. Reitan Director Sale of securities on an exchange or to another person at price $ 478.67 per share. 09 Sep 2025 1,450 2,186 (0%) 0% 478.7 694,072 Common Stock
Colleen F. Reitan Director Sale of securities on an exchange or to another person at price $ 479.55 per share. 09 Sep 2025 1,386 800 (0%) 0% 479.5 664,656 Common Stock
Colleen F. Reitan Director Sale of securities on an exchange or to another person at price $ 481.00 per share. 09 Sep 2025 25 775 (0%) 0% 481 12,025 Common Stock
Colleen F. Reitan Director Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. 09 Sep 2025 18,000 0 - - Stock Option (right to buy)
Colleen F. Reitan Director Exercise or conversion of derivative security received from the company (such as an option) at price $ 100.65 per share. 09 Sep 2025 18,000 18,775 (0%) 0% 100.7 1,811,700 Common Stock
Colleen F. Reitan Director Sale of securities on an exchange or to another person at price $ 457.44 per share. 09 Sep 2025 1,645 17,130 (0%) 0% 457.4 752,489 Common Stock
Colleen F. Reitan Director Sale of securities on an exchange or to another person at price $ 458.86 per share. 09 Sep 2025 1,888 15,242 (0%) 0% 458.9 866,328 Common Stock
Colleen F. Reitan Director Sale of securities on an exchange or to another person at price $ 459.73 per share. 09 Sep 2025 1,403 13,839 (0%) 0% 459.7 645,001 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 449.54 per share. 29 Aug 2025 681 26,402 (0%) 0% 449.5 306,137 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 452.49 per share. 29 Aug 2025 144 25,992 (0%) 0% 452.5 65,159 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 445.53 per share. 29 Aug 2025 195 29,271 (0%) 0% 445.5 86,878 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 446.98 per share. 29 Aug 2025 899 28,372 (0%) 0% 447.0 401,835 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 448.05 per share. 29 Aug 2025 1,289 27,083 (0%) 0% 448.0 577,536 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 451.52 per share. 29 Aug 2025 266 26,136 (0%) 0% 451.5 120,104 Common Stock
Michael W. Bonney Director 18 Aug 2025 11,250 0 - - Stock Option (right to buy)
Michael W. Bonney Director 18 Aug 2025 11,250 16,804 (0%) 0% 450 5,062,500 Common Stock
Michael W. Bonney Director 18 Aug 2025 11,250 28,054 (0%) 0% 70.2 789,750 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 451.99 per share. 15 Aug 2025 514 61,847 (0%) 0% 452.0 232,323 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 450.92 per share. 15 Aug 2025 195 62,361 (0%) 0% 450.9 87,929 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 449.92 per share. 15 Aug 2025 450 62,556 (0%) 0% 449.9 202,464 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 447.98 per share. 15 Aug 2025 194 63,006 (0%) 0% 448.0 86,908 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Grant, award, or other acquisition of securities at price $ 0.00 per share. 15 Aug 2025 14,252 63,200 (0%) 0% 0 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 454.84 per share. 15 Aug 2025 1,204 56,281 (0%) 0% 454.8 547,627 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 454.04 per share. 15 Aug 2025 2,716 57,485 (0%) 0% 454.0 1,233,173 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 455.82 per share. 15 Aug 2025 60 56,221 (0%) 0% 455.8 27,349 Common Stock
Yvonne L Greenstreet Director, Chief Executive Officer Sale of securities on an exchange or to another person at price $ 452.96 per share. 15 Aug 2025 1,646 60,201 (0%) 0% 453.0 745,572 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Grant, award, or other acquisition of securities at price $ 0.00 per share. 15 Aug 2025 4,644 52,395 (0%) 0% 0 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 455.84 per share. 15 Aug 2025 19 50,121 (0%) 0% 455.8 8,661 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 454.84 per share. 15 Aug 2025 392 50,140 (0%) 0% 454.8 178,297 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 454.04 per share. 15 Aug 2025 886 50,532 (0%) 0% 454.0 402,279 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 452.96 per share. 15 Aug 2025 536 51,418 (0%) 0% 453.0 242,787 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 451.99 per share. 15 Aug 2025 168 51,954 (0%) 0% 452.0 75,934 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 450.92 per share. 15 Aug 2025 63 52,122 (0%) 0% 450.9 28,408 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 449.92 per share. 15 Aug 2025 147 52,185 (0%) 0% 449.9 66,138 Common Stock
Jeffrey V. Poulton EVP, Chief Financial Officer Sale of securities on an exchange or to another person at price $ 447.98 per share. 15 Aug 2025 63 52,332 (0%) 0% 448.0 28,223 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 461.01 per share. 15 Aug 2025 305 20,266 (0%) 0% 461.0 140,608 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 459.59 per share. 15 Aug 2025 260 20,571 (0%) 0% 459.6 119,493 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 458.27 per share. 15 Aug 2025 231 20,831 (0%) 0% 458.3 105,860 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 457.26 per share. 15 Aug 2025 338 21,062 (0%) 0% 457.3 154,554 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 455.41 per share. 15 Aug 2025 276 21,400 (0%) 0% 455.4 125,693 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 455.83 per share. 15 Aug 2025 12 21,676 (0%) 0% 455.8 5,470 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 454.84 per share. 15 Aug 2025 241 21,688 (0%) 0% 454.8 109,616 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 454.04 per share. 15 Aug 2025 543 21,929 (0%) 0% 454.0 246,544 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 452.96 per share. 15 Aug 2025 329 22,472 (0%) 0% 453.0 149,024 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 451.99 per share. 15 Aug 2025 103 22,801 (0%) 0% 452.0 46,555 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 450.92 per share. 15 Aug 2025 39 22,904 (0%) 0% 450.9 17,586 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 449.92 per share. 15 Aug 2025 90 22,943 (0%) 0% 449.9 40,493 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 447.97 per share. 15 Aug 2025 39 23,033 (0%) 0% 448.0 17,471 Common Stock
Pushkal P. Garg EVP Chief R&D Grant, award, or other acquisition of securities at price $ 0.00 per share. 15 Aug 2025 2,851 23,072 (0%) 0% 0 Common Stock
Pushkal P. Garg EVP Chief R&D Sale of securities on an exchange or to another person at price $ 461.73 per share. 15 Aug 2025 45 20,221 (0%) 0% 461.7 20,778 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 451.99 per share. 15 Aug 2025 103 30,591 (0%) 0% 452.0 46,555 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 455.83 per share. 15 Aug 2025 12 29,466 (0%) 0% 455.8 5,470 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 454.84 per share. 15 Aug 2025 241 29,478 (0%) 0% 454.8 109,616 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 454.04 per share. 15 Aug 2025 543 29,719 (0%) 0% 454.0 246,544 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 452.96 per share. 15 Aug 2025 329 30,262 (0%) 0% 453.0 149,024 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 450.92 per share. 15 Aug 2025 39 30,694 (0%) 0% 450.9 17,586 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 449.92 per share. 15 Aug 2025 90 30,733 (0%) 0% 449.9 40,493 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Sale of securities on an exchange or to another person at price $ 447.97 per share. 15 Aug 2025 39 30,823 (0%) 0% 448.0 17,471 Common Stock
Tolga Tanguler EVP, Chief Commercial Officer Grant, award, or other acquisition of securities at price $ 0.00 per share. 15 Aug 2025 2,851 30,862 (0%) 0% 0 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 454.84 per share. 15 Aug 2025 241 22,731 (0%) 0% 454.8 109,616 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 455.83 per share. 15 Aug 2025 12 22,719 (0%) 0% 455.8 5,470 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 452.96 per share. 15 Aug 2025 329 23,515 (0%) 0% 453.0 149,024 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 451.99 per share. 15 Aug 2025 103 23,844 (0%) 0% 452.0 46,555 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 450.92 per share. 15 Aug 2025 39 23,947 (0%) 0% 450.9 17,586 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 449.92 per share. 15 Aug 2025 90 23,986 (0%) 0% 449.9 40,493 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 447.97 per share. 15 Aug 2025 39 24,076 (0%) 0% 448.0 17,471 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Grant, award, or other acquisition of securities at price $ 0.00 per share. 15 Aug 2025 2,851 24,115 (0%) 0% 0 Common Stock
Kevin Joseph Fitzgerald CSO & EVP, Head of Research Sale of securities on an exchange or to another person at price $ 454.04 per share. 15 Aug 2025 543 22,972 (0%) 0% 454.0 246,544 Common Stock
*All Values are in $ Million
Client Category: Promoter/ KMP/ Director / Immediate Relatives / Employee / etc  
Security Type: Share/ Warrants / Convertible Debentures
Data as reported to USA Exchanges
View All The Insider Trades disclosures
Screeners based on Insider Trading and SAST parameters