XNAS 11 Nov, 2025 4:16 PM (EST)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 53.62 per share. | 05 Nov 2025 | 2,300 | 290,493 | - | 53.6 | 123,326 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 54.83 per share. | 05 Nov 2025 | 2,200 | 288,293 | - | 54.8 | 120,626 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 05 Nov 2025 | 8,060 | 292,793 | - | 22.9 | 184,252 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 56.51 per share. | 05 Nov 2025 | 678 | 282,008 | - | 56.5 | 38,314 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Nov 2025 | 8,060 | 153,565 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 55.58 per share. | 05 Nov 2025 | 5,607 | 282,686 | - | 55.6 | 311,637 | Common Stock |
| Nimish Shah | Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 10 Oct 2025 | 365,853 | 365,853 | - | - | Pre-Funded Warrants (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2025 | 2,385 | 161,625 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 39.80 per share. | 01 Oct 2025 | 5,110 | 284,733 | - | 39.8 | 203,378 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 01 Oct 2025 | 2,385 | 289,843 | - | 22.9 | 54,521 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 37.82 per share. | 03 Sep 2025 | 2,535 | 233,738 | - | 37.8 | 95,874 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 38.55 per share. | 03 Sep 2025 | 190 | 233,548 | - | 38.6 | 7,325 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 37.78 per share. | 06 Aug 2025 | 2,725 | 236,273 | - | 37.8 | 102,951 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 02 Jul 2025 | 7,365 | 249,088 | - | 22.9 | 168,364 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 44.77 per share. | 02 Jul 2025 | 6,409 | 242,679 | - | 44.8 | 286,931 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 45.49 per share. | 02 Jul 2025 | 2,935 | 239,744 | - | 45.5 | 133,513 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 46.26 per share. | 02 Jul 2025 | 746 | 238,998 | - | 46.3 | 34,510 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jul 2025 | 7,365 | 164,010 | - | - | Stock Option (Right to Buy) | |
| Jennifer A. Fox | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2025 | 14,461 | 14,461 | - | - | Stock Option (Right to Buy) | |
| William Jones | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2025 | 14,461 | 14,461 | - | - | Stock Option (Right to Buy) | |
| Mark C. McKenna | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2025 | 14,461 | 14,461 | - | - | Stock Option (Right to Buy) | |
| Nimish Shah | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2025 | 14,461 | 14,461 | - | - | Stock Option (Right to Buy) | |
| Andrew Gottesdiener | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2025 | 14,461 | 14,461 | - | - | Stock Option (Right to Buy) | |
| Lisa L. Bollinger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2025 | 14,461 | 14,461 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 36.96 per share. | 04 Jun 2025 | 2,725 | 241,723 | - | 37.0 | 100,716 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 35.75 per share. | 07 May 2025 | 2,725 | 244,448 | - | 35.8 | 97,419 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 37.59 per share. | 02 Apr 2025 | 889 | 247,173 | - | 37.6 | 33,418 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 37.03 per share. | 02 Apr 2025 | 500 | 248,062 | - | 37.0 | 18,515 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 35.56 per share. | 02 Apr 2025 | 2,471 | 248,562 | - | 35.6 | 87,869 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 30.62 per share. | 05 Mar 2025 | 2,674 | 1,292,987 | - | 30.6 | 81,878 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 29.98 per share. | 05 Mar 2025 | 7,326 | 1,295,661 | - | 30.0 | 219,633 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 30.48 per share. | 05 Mar 2025 | 1,590 | 251,033 | - | 30.5 | 48,463 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 40.69 per share. | 05 Feb 2025 | 3,520 | 252,623 | - | 40.7 | 143,229 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2025 | 795 | 171,375 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 05 Feb 2025 | 795 | 256,143 | - | 22.9 | 18,174 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 40.58 per share. | 05 Feb 2025 | 15,000 | 1,302,987 | - | 40.6 | 608,700 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 8,500 | 390,012 | - | - | Stock Option (Right to Buy) | |
| Michael Henderson | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 31 Jan 2025 | 8,500 | 1,317,987 | - | 22.9 | 194,310 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 1,360 | 172,170 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 47.92 per share. | 02 Jan 2025 | 100 | 255,348 | - | 47.9 | 4,792 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 47.21 per share. | 02 Jan 2025 | 2,486 | 255,448 | - | 47.2 | 117,364 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 46.42 per share. | 02 Jan 2025 | 1,499 | 257,934 | - | 46.4 | 69,584 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 02 Jan 2025 | 1,360 | 259,433 | - | 22.9 | 31,090 | Common Stock |
| Mark McKenna C. | Director | Purchase of securities on an exchange or from another person at price $ 49.85 per share. | 12 Dec 2024 | 12,500 | 20,000 | - | 49.9 | 623,125 | Common Stock |
| C. Mark McKenna | Director | Purchase of securities on an exchange or from another person at price $ 49.02 per share. | 12 Dec 2024 | 7,500 | 7,500 | - | 49.0 | 367,650 | Common Stock |
| Dambkowski Carl | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 48.62 per share. | 11 Dec 2024 | 4,085 | 258,528 | - | 48.6 | 198,613 | Common Stock |
| Dambkowski Carl | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 50.00 per share. | 11 Dec 2024 | 455 | 258,073 | - | 50 | 22,750 | Common Stock |
| Dambkowski Carl | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 11 Dec 2024 | 1,815 | 262,613 | - | 22.9 | 41,491 | Common Stock |
| Dambkowski Carl | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Dec 2024 | 1,815 | 173,530 | - | - | Stock Option (Right to Buy) | |
| Jane Pritchett Henderson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Dec 2024 | 124,962 | 124,962 | - | - | Stock Option (Right to Buy) | |
| Michael Henderson | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Dec 2024 | 357,036 | 357,036 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Dec 2024 | 124,962 | 124,962 | - | - | Stock Option (Right to Buy) | |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 47.19 per share. | 04 Dec 2024 | 1,672 | 1,324,487 | - | 47.2 | 78,902 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 46.50 per share. | 04 Dec 2024 | 13,328 | 1,326,159 | - | 46.5 | 619,752 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 46.07 per share. | 04 Dec 2024 | 6,665 | 260,798 | - | 46.1 | 307,057 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 59.96 per share. | 06 Nov 2024 | 1,339 | 267,463 | - | 60.0 | 80,286 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 58.91 per share. | 06 Nov 2024 | 5,326 | 268,802 | - | 58.9 | 313,755 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 59.94 per share. | 06 Nov 2024 | 1,000 | 1,339,487 | - | 59.9 | 59,940 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 59.17 per share. | 06 Nov 2024 | 14,000 | 1,340,487 | - | 59.2 | 828,380 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 56.16 per share. | 02 Oct 2024 | 5,740 | 275,053 | - | 56.2 | 322,358 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 56.86 per share. | 02 Oct 2024 | 925 | 274,128 | - | 56.9 | 52,596 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 56.07 per share. | 02 Oct 2024 | 30,288 | 1,364,199 | - | 56.1 | 1,698,248 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 56.74 per share. | 02 Oct 2024 | 9,712 | 1,354,487 | - | 56.7 | 551,059 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 47.49 per share. | 04 Sep 2024 | 5,878 | 281,580 | - | 47.5 | 279,146 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 48.23 per share. | 04 Sep 2024 | 14,359 | 1,394,487 | - | 48.2 | 692,535 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 48.06 per share. | 04 Sep 2024 | 787 | 280,793 | - | 48.1 | 37,823 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 47.28 per share. | 04 Sep 2024 | 25,641 | 1,408,846 | - | 47.3 | 1,212,306 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 48.26 per share. | 23 Aug 2024 | 6,000 | 200,871 | - | 48.3 | 289,560 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 41.09 per share. | 07 Aug 2024 | 142 | 288,128 | - | 41.1 | 5,835 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 42.56 per share. | 07 Aug 2024 | 670 | 287,458 | - | 42.6 | 28,515 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 40.47 per share. | 07 Aug 2024 | 6,523 | 288,270 | - | 40.5 | 263,986 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 41.52 per share. | 07 Aug 2024 | 7,667 | 1,434,587 | - | 41.5 | 318,334 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 42.17 per share. | 07 Aug 2024 | 100 | 1,434,487 | - | 42.2 | 4,217 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 40.40 per share. | 07 Aug 2024 | 32,233 | 1,442,254 | - | 40.4 | 1,302,213 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 37.26 per share. | 05 Jul 2024 | 15,000 | 1,474,487 | - | 37.3 | 558,900 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 37.29 per share. | 03 Jul 2024 | 3,852 | 296,936 | - | 37.3 | 143,641 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 38.16 per share. | 03 Jul 2024 | 2,143 | 294,793 | - | 38.2 | 81,777 | Common Stock |
| Lisa L. Bollinger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 8,112 | 8,112 | - | - | Stock Option (Right to Buy) | |
| Andrew Gottesdiener | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 10,370 | 10,370 | - | - | Stock Option (Right to Buy) | |
| Nimish Shah | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 10,370 | 10,370 | - | - | Stock Option (Right to Buy) | |
| Jennifer A. Fox | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 10,370 | 10,370 | - | - | Stock Option (Right to Buy) | |
| Mark C. McKenna | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 10,370 | 10,370 | - | - | Stock Option (Right to Buy) | |
| William B.J. Jones | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 10,370 | 10,370 | - | - | Stock Option (Right to Buy) | |
| Lisa L. Bollinger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 May 2024 | 18,550 | 18,550 | - | - | Stock Option (Right to Buy) | |
| Henderson Pritchett Jane | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2023 | 175,345 | 175,345 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2023 | 175,345 | 175,345 | - | - | Stock Option (Right to Buy) | |
| Henderson Michael | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2023 | 398,512 | 398,512 | - | - | Stock Option (Right to Buy) | |
| McKenna Mark C. | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Aug 2023 | 100,000 | 150,000 | - | - | Stock Option (Right to Buy) | |
| C. Mark McKenna | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Aug 2023 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Nimish Shah | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jul 2023 | 47,758 | 47,758 | - | - | Stock Option (Right to Buy) | |
| Andrew Gottesdiener | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jul 2023 | 47,758 | 47,758 | - | - | Stock Option (Right to Buy) | |
| Nimish Shah | Director | Purchase of securities on an exchange or from another person at price $ 17.00 per share. | 13 Jul 2023 | 1,750,000 | 1,750,000 | - | 17 | 29,750,000 | Common Stock |