5.0M
XNAS Volume
High volume today
XNAS 02 Sep, 2026 5:30 PM (EDT)
Market Cap
High in industry
PE TTM
Negative PE TTM
PEG TTM
PEG TTM is much higher than 1
Price to Book
High in industry
Beta 1Year
Very Low volatility
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 05 Aug 2026 | 4,125 | 173,998 | - | 22.9 | 94,298 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Aug 2026 | 4,125 | 110,665 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 134.17 per share. | 05 Aug 2026 | 5,500 | 168,498 | - | 134.2 | 737,935 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 24 Jul 2026 | 15,000 | 158,371 | - | 0 | Common Stock | |
| Carl Dambkowski | Chief Medical Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 14 Jul 2026 | 8,000 | 169,873 | - | 0 | Common Stock | |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 133.63 per share. | 08 Jul 2026 | 20,000 | 995,987 | - | 133.6 | 2,672,600 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 08 Jul 2026 | 75,046 | 920,941 | - | 0 | Common Stock | |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 132.74 per share. | 01 Jul 2026 | 5,500 | 177,873 | - | 132.7 | 730,070 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2026 | 4,125 | 114,790 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 01 Jul 2026 | 4,125 | 183,373 | - | 22.9 | 94,298 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 132.54 per share. | 22 Jun 2026 | 80,000 | 1,015,987 | - | 132.5 | 10,603,200 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 132.60 per share. | 22 Jun 2026 | 26,400 | 179,248 | - | 132.6 | 3,500,640 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 82.21 per share. | 10 Jun 2026 | 6,770 | 1,109,217 | - | 82.2 | 556,562 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 86.89 per share. | 10 Jun 2026 | 614 | 1,095,987 | - | 86.9 | 53,350 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 86.27 per share. | 10 Jun 2026 | 2,305 | 1,096,601 | - | 86.3 | 198,852 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 85.19 per share. | 10 Jun 2026 | 1,577 | 1,098,906 | - | 85.2 | 134,345 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 84.18 per share. | 10 Jun 2026 | 1,080 | 1,100,483 | - | 84.2 | 90,914 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 82.78 per share. | 10 Jun 2026 | 7,654 | 1,101,563 | - | 82.8 | 633,598 | Common Stock |
| William Jones | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2026 | 7,657 | 7,657 | - | - | Stock Option (Right to Buy) | |
| Mark C. McKenna | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2026 | 7,657 | 7,657 | - | - | Stock Option (Right to Buy) | |
| Jennifer A. Fox | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2026 | 7,657 | 7,657 | - | - | Stock Option (Right to Buy) | |
| Nimish Shah | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2026 | 7,657 | 7,657 | - | - | Stock Option (Right to Buy) | |
| Lisa L. Bollinger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2026 | 7,657 | 7,657 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 03 Jun 2026 | 4,125 | 211,148 | - | 22.9 | 94,298 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 78.71 per share. | 03 Jun 2026 | 5,500 | 205,648 | - | 78.7 | 432,905 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jun 2026 | 4,125 | 118,915 | - | - | Stock Option (Right to Buy) | |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 82.05 per share. | 13 May 2026 | 18,659 | 1,117,328 | - | 82.1 | 1,530,971 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 82.58 per share. | 13 May 2026 | 1,341 | 1,115,987 | - | 82.6 | 110,740 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 83.92 per share. | 06 May 2026 | 3,700 | 208,823 | - | 83.9 | 310,504 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 May 2026 | 4,125 | 123,040 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 84.60 per share. | 06 May 2026 | 1,800 | 207,023 | - | 84.6 | 152,280 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 06 May 2026 | 4,125 | 212,523 | - | 22.9 | 94,298 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 82.60 per share. | 01 May 2026 | 900 | 173,660 | - | 82.6 | 74,340 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 81.02 per share. | 01 May 2026 | 811 | 174,560 | - | 81.0 | 65,707 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 83.16 per share. | 01 May 2026 | 289 | 173,371 | - | 83.2 | 24,033 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 90.00 per share. | 16 Apr 2026 | 2,000 | 175,371 | - | 90 | 180,000 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Apr 2026 | 3,000 | 387,012 | - | - | Stock Option (Right to Buy) | |
| Michael Henderson | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 16 Apr 2026 | 3,000 | 1,135,987 | - | 22.9 | 68,580 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 82.48 per share. | 08 Apr 2026 | 17,800 | 1,135,187 | - | 82.5 | 1,468,144 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 83.26 per share. | 08 Apr 2026 | 2,000 | 1,133,187 | - | 83.3 | 166,520 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 85.00 per share. | 08 Apr 2026 | 200 | 1,132,987 | - | 85 | 17,000 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 84.46 per share. | 01 Apr 2026 | 900 | 178,471 | - | 84.5 | 76,014 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 85.46 per share. | 01 Apr 2026 | 1,100 | 177,371 | - | 85.5 | 94,006 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 01 Apr 2026 | 4,125 | 213,898 | - | 22.9 | 94,298 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 85.33 per share. | 01 Apr 2026 | 2,702 | 208,498 | - | 85.3 | 230,562 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 84.31 per share. | 01 Apr 2026 | 2,698 | 211,200 | - | 84.3 | 227,468 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2026 | 4,125 | 127,165 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 85.89 per share. | 01 Apr 2026 | 100 | 208,398 | - | 85.9 | 8,589 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 85.00 per share. | 25 Mar 2026 | 2,000 | 179,371 | - | 85 | 170,000 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 74.83 per share. | 11 Mar 2026 | 8,219 | 1,156,405 | - | 74.8 | 615,028 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 74.29 per share. | 11 Mar 2026 | 8,363 | 1,164,624 | - | 74.3 | 621,287 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 75.86 per share. | 11 Mar 2026 | 3,418 | 1,152,987 | - | 75.9 | 259,289 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 73.26 per share. | 04 Mar 2026 | 200 | 209,773 | - | 73.3 | 14,652 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 71.98 per share. | 04 Mar 2026 | 2,075 | 209,973 | - | 72.0 | 149,359 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 70.33 per share. | 04 Mar 2026 | 3,225 | 212,048 | - | 70.3 | 226,814 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 04 Mar 2026 | 4,125 | 215,273 | - | 22.9 | 94,298 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2026 | 4,125 | 131,290 | - | - | Stock Option (Right to Buy) | |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 68.27 per share. | 02 Mar 2026 | 300 | 183,071 | - | 68.3 | 20,481 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 69.43 per share. | 02 Mar 2026 | 300 | 182,771 | - | 69.4 | 20,829 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 71.66 per share. | 02 Mar 2026 | 406 | 181,371 | - | 71.7 | 29,094 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 70.45 per share. | 02 Mar 2026 | 994 | 181,777 | - | 70.4 | 70,027 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 63.73 per share. | 11 Feb 2026 | 7,551 | 1,173,942 | - | 63.7 | 481,225 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 64.99 per share. | 11 Feb 2026 | 955 | 1,172,987 | - | 65.0 | 62,065 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 62.96 per share. | 11 Feb 2026 | 11,494 | 1,181,493 | - | 63.0 | 723,662 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 04 Feb 2026 | 4,125 | 216,648 | - | 22.9 | 94,298 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Feb 2026 | 4,125 | 135,415 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 68.94 per share. | 04 Feb 2026 | 200 | 211,148 | - | 68.9 | 13,788 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 67.88 per share. | 04 Feb 2026 | 100 | 211,348 | - | 67.9 | 6,788 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 66.85 per share. | 04 Feb 2026 | 1,299 | 211,448 | - | 66.8 | 86,838 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 65.83 per share. | 04 Feb 2026 | 1,420 | 212,747 | - | 65.8 | 93,479 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 64.88 per share. | 04 Feb 2026 | 2,481 | 214,167 | - | 64.9 | 160,967 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 66.15 per share. | 02 Feb 2026 | 1,108 | 183,471 | - | 66.1 | 73,294 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 66.89 per share. | 02 Feb 2026 | 100 | 183,371 | - | 66.9 | 6,689 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 65.21 per share. | 02 Feb 2026 | 792 | 184,579 | - | 65.2 | 51,646 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 83.79 per share. | 14 Jan 2026 | 470 | 1,192,987 | - | 83.8 | 39,381 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 83.16 per share. | 14 Jan 2026 | 5,386 | 1,193,457 | - | 83.2 | 447,900 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 82.41 per share. | 14 Jan 2026 | 1,854 | 1,198,843 | - | 82.4 | 152,788 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 78.64 per share. | 14 Jan 2026 | 1,440 | 1,211,547 | - | 78.6 | 113,242 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 81.00 per share. | 14 Jan 2026 | 2,374 | 1,200,697 | - | 81 | 192,294 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 79.82 per share. | 14 Jan 2026 | 8,476 | 1,203,071 | - | 79.8 | 676,554 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jan 2026 | 14,025 | 139,540 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 07 Jan 2026 | 14,025 | 231,223 | - | 22.9 | 320,612 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 77.13 per share. | 07 Jan 2026 | 2,954 | 228,269 | - | 77.1 | 227,842 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 77.90 per share. | 07 Jan 2026 | 14,820 | 213,449 | - | 77.9 | 1,154,478 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 79.04 per share. | 07 Jan 2026 | 826 | 212,623 | - | 79.0 | 65,287 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 80.06 per share. | 07 Jan 2026 | 100 | 212,523 | - | 80.1 | 8,006 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 74.13 per share. | 02 Jan 2026 | 1,920 | 191,451 | - | 74.1 | 142,330 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 75.20 per share. | 02 Jan 2026 | 4,080 | 187,371 | - | 75.2 | 306,816 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 80.00 per share. | 02 Jan 2026 | 2,000 | 185,371 | - | 80 | 160,000 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 83,690 | 83,690 | - | - | Stock Option (Right to Buy) | |
| Michael Henderson | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 253,016 | 253,016 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 83,690 | 83,690 | - | - | Stock Option (Right to Buy) | |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 80.00 per share. | 19 Dec 2025 | 1,500 | 193,371 | - | 80 | 120,000 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 75.79 per share. | 10 Dec 2025 | 10,005 | 1,213,547 | - | 75.8 | 758,279 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 74.88 per share. | 10 Dec 2025 | 9,435 | 1,223,552 | - | 74.9 | 706,493 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 76.58 per share. | 10 Dec 2025 | 560 | 1,212,987 | - | 76.6 | 42,885 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 75.00 per share. | 04 Dec 2025 | 1,500 | 194,871 | - | 75 | 112,500 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 75.01 per share. | 04 Dec 2025 | 40,000 | 1,232,987 | - | 75.0 | 3,000,400 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 75.00 per share. | 04 Dec 2025 | 10,900 | 271,108 | - | 75 | 817,500 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 70.00 per share. | 25 Nov 2025 | 1,500 | 196,371 | - | 70 | 105,000 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 65.00 per share. | 14 Nov 2025 | 2,000 | 197,871 | - | 65 | 130,000 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 64.52 per share. | 13 Nov 2025 | 100 | 1,272,987 | - | 64.5 | 6,452 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 63.89 per share. | 13 Nov 2025 | 1,786 | 1,273,087 | - | 63.9 | 114,108 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 63.14 per share. | 13 Nov 2025 | 14,774 | 1,274,873 | - | 63.1 | 932,830 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 61.93 per share. | 13 Nov 2025 | 3,340 | 1,289,647 | - | 61.9 | 206,846 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 60.00 per share. | 11 Nov 2025 | 1,000 | 199,871 | - | 60 | 60,000 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 55.58 per share. | 05 Nov 2025 | 5,607 | 282,686 | - | 55.6 | 311,637 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Nov 2025 | 8,060 | 153,565 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 56.51 per share. | 05 Nov 2025 | 678 | 282,008 | - | 56.5 | 38,314 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 05 Nov 2025 | 8,060 | 292,793 | - | 22.9 | 184,252 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 54.83 per share. | 05 Nov 2025 | 2,200 | 288,293 | - | 54.8 | 120,626 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 53.62 per share. | 05 Nov 2025 | 2,300 | 290,493 | - | 53.6 | 123,326 | Common Stock |
| Nimish Shah | Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 10 Oct 2025 | 365,853 | 365,853 | - | - | Pre-Funded Warrants (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2025 | 2,385 | 161,625 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 39.80 per share. | 01 Oct 2025 | 5,110 | 284,733 | - | 39.8 | 203,378 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 01 Oct 2025 | 2,385 | 289,843 | - | 22.9 | 54,521 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 38.55 per share. | 03 Sep 2025 | 190 | 233,548 | - | 38.6 | 7,325 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 37.82 per share. | 03 Sep 2025 | 2,535 | 233,738 | - | 37.8 | 95,874 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 37.78 per share. | 06 Aug 2025 | 2,725 | 236,273 | - | 37.8 | 102,951 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jul 2025 | 7,365 | 164,010 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 46.26 per share. | 02 Jul 2025 | 746 | 238,998 | - | 46.3 | 34,510 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 45.49 per share. | 02 Jul 2025 | 2,935 | 239,744 | - | 45.5 | 133,513 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 44.77 per share. | 02 Jul 2025 | 6,409 | 242,679 | - | 44.8 | 286,931 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 02 Jul 2025 | 7,365 | 249,088 | - | 22.9 | 168,364 | Common Stock |
| William Jones | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2025 | 14,461 | 14,461 | - | - | Stock Option (Right to Buy) | |
| Mark C. McKenna | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2025 | 14,461 | 14,461 | - | - | Stock Option (Right to Buy) | |
| Jennifer A. Fox | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2025 | 14,461 | 14,461 | - | - | Stock Option (Right to Buy) | |
| Nimish Shah | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2025 | 14,461 | 14,461 | - | - | Stock Option (Right to Buy) | |
| Andrew Gottesdiener | Director | 17 Jun 2025 | 14,461 | 14,461 | - | - | Stock Option (Right to Buy) | ||
| Lisa L. Bollinger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2025 | 14,461 | 14,461 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 36.96 per share. | 04 Jun 2025 | 2,725 | 241,723 | - | 37.0 | 100,716 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 35.75 per share. | 07 May 2025 | 2,725 | 244,448 | - | 35.8 | 97,419 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 35.56 per share. | 02 Apr 2025 | 2,471 | 248,562 | - | 35.6 | 87,869 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 37.03 per share. | 02 Apr 2025 | 500 | 248,062 | - | 37.0 | 18,515 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 37.59 per share. | 02 Apr 2025 | 889 | 247,173 | - | 37.6 | 33,418 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 30.62 per share. | 05 Mar 2025 | 2,674 | 1,292,987 | - | 30.6 | 81,878 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 29.98 per share. | 05 Mar 2025 | 7,326 | 1,295,661 | - | 30.0 | 219,633 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 30.48 per share. | 05 Mar 2025 | 1,590 | 251,033 | - | 30.5 | 48,463 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 40.58 per share. | 05 Feb 2025 | 15,000 | 1,302,987 | - | 40.6 | 608,700 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 05 Feb 2025 | 795 | 256,143 | - | 22.9 | 18,174 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2025 | 795 | 171,375 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 40.69 per share. | 05 Feb 2025 | 3,520 | 252,623 | - | 40.7 | 143,229 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 31 Jan 2025 | 8,500 | 1,317,987 | - | 22.9 | 194,310 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 8,500 | 390,012 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 02 Jan 2025 | 1,360 | 259,433 | - | 22.9 | 31,090 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 46.42 per share. | 02 Jan 2025 | 1,499 | 257,934 | - | 46.4 | 69,584 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 47.21 per share. | 02 Jan 2025 | 2,486 | 255,448 | - | 47.2 | 117,364 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 47.92 per share. | 02 Jan 2025 | 100 | 255,348 | - | 47.9 | 4,792 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 1,360 | 172,170 | - | - | Stock Option (Right to Buy) | |
| C. Mark McKenna | Director | Purchase of securities on an exchange or from another person at price $ 49.02 per share. | 12 Dec 2024 | 7,500 | 7,500 | - | 49.0 | 367,650 | Common Stock |
| Mark McKenna C. | Director | Purchase of securities on an exchange or from another person at price $ 49.85 per share. | 12 Dec 2024 | 12,500 | 20,000 | - | 49.9 | 623,125 | Common Stock |
| Dambkowski Carl | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Dec 2024 | 1,815 | 173,530 | - | - | Stock Option (Right to Buy) | |
| Dambkowski Carl | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 50.00 per share. | 11 Dec 2024 | 455 | 258,073 | - | 50 | 22,750 | Common Stock |
| Dambkowski Carl | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 48.62 per share. | 11 Dec 2024 | 4,085 | 258,528 | - | 48.6 | 198,613 | Common Stock |
| Dambkowski Carl | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.86 per share. | 11 Dec 2024 | 1,815 | 262,613 | - | 22.9 | 41,491 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Dec 2024 | 124,962 | 124,962 | - | - | Stock Option (Right to Buy) | |
| Michael Henderson | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Dec 2024 | 357,036 | 357,036 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Dec 2024 | 124,962 | 124,962 | - | - | Stock Option (Right to Buy) | |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 47.19 per share. | 04 Dec 2024 | 1,672 | 1,324,487 | - | 47.2 | 78,902 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 46.50 per share. | 04 Dec 2024 | 13,328 | 1,326,159 | - | 46.5 | 619,752 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 46.07 per share. | 04 Dec 2024 | 6,665 | 260,798 | - | 46.1 | 307,057 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 59.17 per share. | 06 Nov 2024 | 14,000 | 1,340,487 | - | 59.2 | 828,380 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 59.94 per share. | 06 Nov 2024 | 1,000 | 1,339,487 | - | 59.9 | 59,940 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 58.91 per share. | 06 Nov 2024 | 5,326 | 268,802 | - | 58.9 | 313,755 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 59.96 per share. | 06 Nov 2024 | 1,339 | 267,463 | - | 60.0 | 80,286 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 56.74 per share. | 02 Oct 2024 | 9,712 | 1,354,487 | - | 56.7 | 551,059 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 56.07 per share. | 02 Oct 2024 | 30,288 | 1,364,199 | - | 56.1 | 1,698,248 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 56.86 per share. | 02 Oct 2024 | 925 | 274,128 | - | 56.9 | 52,596 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 56.16 per share. | 02 Oct 2024 | 5,740 | 275,053 | - | 56.2 | 322,358 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 47.49 per share. | 04 Sep 2024 | 5,878 | 281,580 | - | 47.5 | 279,146 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 48.23 per share. | 04 Sep 2024 | 14,359 | 1,394,487 | - | 48.2 | 692,535 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 47.28 per share. | 04 Sep 2024 | 25,641 | 1,408,846 | - | 47.3 | 1,212,306 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 48.06 per share. | 04 Sep 2024 | 787 | 280,793 | - | 48.1 | 37,823 | Common Stock |
| Jane Pritchett Henderson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 48.26 per share. | 23 Aug 2024 | 6,000 | 200,871 | - | 48.3 | 289,560 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 40.40 per share. | 07 Aug 2024 | 32,233 | 1,442,254 | - | 40.4 | 1,302,213 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 42.17 per share. | 07 Aug 2024 | 100 | 1,434,487 | - | 42.2 | 4,217 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 41.52 per share. | 07 Aug 2024 | 7,667 | 1,434,587 | - | 41.5 | 318,334 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 40.47 per share. | 07 Aug 2024 | 6,523 | 288,270 | - | 40.5 | 263,986 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 42.56 per share. | 07 Aug 2024 | 670 | 287,458 | - | 42.6 | 28,515 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 41.09 per share. | 07 Aug 2024 | 142 | 288,128 | - | 41.1 | 5,835 | Common Stock |
| Michael Henderson | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 37.26 per share. | 05 Jul 2024 | 15,000 | 1,474,487 | - | 37.3 | 558,900 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 38.16 per share. | 03 Jul 2024 | 2,143 | 294,793 | - | 38.2 | 81,777 | Common Stock |
| Carl Dambkowski | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 37.29 per share. | 03 Jul 2024 | 3,852 | 296,936 | - | 37.3 | 143,641 | Common Stock |
| William B.J. Jones | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 10,370 | 10,370 | - | - | Stock Option (Right to Buy) | |
| Mark C. McKenna | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 10,370 | 10,370 | - | - | Stock Option (Right to Buy) | |
| Jennifer A. Fox | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 10,370 | 10,370 | - | - | Stock Option (Right to Buy) | |
| Nimish Shah | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 10,370 | 10,370 | - | - | Stock Option (Right to Buy) | |
| Andrew Gottesdiener | Director | 05 Jun 2024 | 10,370 | 10,370 | - | - | Stock Option (Right to Buy) | ||
| Lisa L. Bollinger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 8,112 | 8,112 | - | - | Stock Option (Right to Buy) | |
| Lisa L. Bollinger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 May 2024 | 18,550 | 18,550 | - | - | Stock Option (Right to Buy) | |
| Henderson Michael | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2023 | 398,512 | 398,512 | - | - | Stock Option (Right to Buy) | |
| Carl Dambkowski | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2023 | 175,345 | 175,345 | - | - | Stock Option (Right to Buy) | |
| Henderson Pritchett Jane | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2023 | 175,345 | 175,345 | - | - | Stock Option (Right to Buy) | |
| C. Mark McKenna | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Aug 2023 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| McKenna Mark C. | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Aug 2023 | 100,000 | 150,000 | - | - | Stock Option (Right to Buy) | |
| Nimish Shah | Director | Purchase of securities on an exchange or from another person at price $ 17.00 per share. | 13 Jul 2023 | 1,750,000 | 1,750,000 | - | 17 | 29,750,000 | Common Stock |
| Nimish Shah | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jul 2023 | 47,758 | 47,758 | - | - | Stock Option (Right to Buy) | |
| Andrew Gottesdiener | Director | 13 Jul 2023 | 47,758 | 47,758 | - | - | Stock Option (Right to Buy) |