XNAS 11 Sep, 2026 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Robert B. Barrow | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Sep 2026 | 40,000 | 1,513,663 | - | 0 | Common Shares | |
| Robert B. Barrow | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 37.94 per share. | 02 Sep 2026 | 19,023 | 1,494,640 | - | 37.9 | 721,733 | Common Shares |
| Dan Karlin | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Aug 2026 | 100,000 | 603,282 | - | 0 | Common Shares | |
| Robert B. Barrow | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Aug 2026 | 375,000 | 1,473,246 | - | 0 | Common Shares | |
| Matthew T. Wiley | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Aug 2026 | 62,500 | 237,133 | - | 0 | Common Shares | |
| Brandi L. Roberts | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Aug 2026 | 62,500 | 271,987 | - | 0 | Common Shares | |
| Mark R. Sullivan | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Aug 2026 | 62,500 | 383,071 | - | 0 | Common Shares | |
| Mark R. Sullivan | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 45.03 per share. | 25 Jun 2026 | 13,008 | 320,571 | - | 45.0 | 585,750 | Common Shares |
| Brandi L. Roberts | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 45.03 per share. | 25 Jun 2026 | 3,013 | 209,487 | - | 45.0 | 135,675 | Common Shares |
| Matthew T. Wiley | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 45.03 per share. | 25 Jun 2026 | 2,867 | 174,633 | - | 45.0 | 129,101 | Common Shares |
| Robert B. Barrow | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 45.03 per share. | 25 Jun 2026 | 29,208 | 1,098,246 | - | 45.0 | 1,315,236 | Common Shares |
| Dan Karlin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 45.03 per share. | 25 Jun 2026 | 10,035 | 503,282 | - | 45.0 | 451,876 | Common Shares |
| Dan Karlin | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2026 | 100,000 | 513,317 | - | 0 | Common Shares | |
| Robert B. Barrow | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2026 | 375,000 | 1,127,454 | - | 0 | Common Shares | |
| Matthew T. Wiley | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2026 | 62,500 | 177,500 | - | 0 | Common Shares | |
| Brandi L. Roberts | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2026 | 62,500 | 212,500 | - | 0 | Common Shares | |
| Mark R. Sullivan | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2026 | 62,500 | 333,579 | - | 0 | Common Shares | |
| Roger Crystal | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2026 | 4,666 | 24,289 | - | 0 | Common Shares | |
| Andreas Krebs | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2026 | 4,666 | 19,773 | - | 0 | Common Shares | |
| Andreas Krebs | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2026 | 19,188 | 19,188 | - | - | Stock Option (Right to Buy) | |
| David W. Gryska | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2026 | 19,188 | 19,188 | - | - | Stock Option (Right to Buy) | |
| David W. Gryska | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2026 | 4,666 | 19,900 | - | 0 | Common Shares | |
| Carol A. Vallone | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2026 | 19,188 | 19,188 | - | - | Stock Option (Right to Buy) | |
| Carol A. Vallone | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2026 | 4,666 | 21,210 | - | 0 | Common Shares | |
| Roger Crystal | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2026 | 19,188 | 19,188 | - | - | Stock Option (Right to Buy) | |
| Suzanne L. Bruhn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2026 | 19,188 | 19,188 | - | - | Stock Option (Right to Buy) | |
| Suzanne L. Bruhn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2026 | 4,666 | 24,289 | - | 0 | Common Shares | |
| Roger Adsett | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2026 | 14,620 | 14,620 | - | - | Stock Option (Right to Buy) | |
| Roger Adsett | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2026 | 3,555 | 3,555 | - | 0 | Common Shares | |
| Dan Karlin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 18.47 per share. | 25 Mar 2026 | 8,018 | 413,317 | - | 18.5 | 148,092 | Common Shares |
| Robert B. Barrow | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 18.47 per share. | 25 Mar 2026 | 24,431 | 752,454 | - | 18.5 | 451,241 | Common Shares |
| Mark R. Sullivan | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 18.47 per share. | 25 Mar 2026 | 10,702 | 271,079 | - | 18.5 | 197,666 | Common Shares |
| Robert B. Barrow | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2026 | 320,000 | 1,098,477 | - | 0 | Common Shares | |
| Mark R. Sullivan | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2026 | 125,000 | 407,576 | - | 0 | Common Shares | |
| Brandi L. Roberts | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2026 | 150,000 | 150,000 | - | 0 | Common Shares | |
| Matthew T. Wiley | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2026 | 115,000 | 115,000 | - | 0 | Common Shares | |
| Dan Karlin | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2026 | 150,000 | 575,025 | - | 0 | Common Shares | |
| Roger Adsett | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2026 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Dan Karlin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 13.15 per share. | 26 Dec 2025 | 5,600 | 425,025 | - | 13.1 | 73,623 | Common Shares |
| Robert B. Barrow | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 13.15 per share. | 26 Dec 2025 | 25,791 | 778,477 | - | 13.1 | 339,072 | Common Shares |
| Mark R. Sullivan | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 13.15 per share. | 26 Dec 2025 | 11,276 | 282,576 | - | 13.1 | 148,244 | Common Shares |
| Dan Karlin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 9.77 per share. | 25 Sep 2025 | 7,704 | 430,625 | - | 9.8 | 75,268 | Common Shares |
| Robert B. Barrow | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 9.77 per share. | 25 Sep 2025 | 25,797 | 804,268 | - | 9.8 | 252,037 | Common Shares |
| Mark R. Sullivan | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 9.77 per share. | 25 Sep 2025 | 11,278 | 293,852 | - | 9.8 | 110,186 | Common Shares |
| Mark R. Sullivan | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 6.80 per share. | 25 Jun 2025 | 11,491 | 305,130 | - | 6.8 | 78,139 | Common Shares |
| Dan Karlin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 6.80 per share. | 25 Jun 2025 | 7,848 | 438,329 | - | 6.8 | 53,366 | Common Shares |
| Robert B. Barrow | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 6.80 per share. | 25 Jun 2025 | 26,491 | 830,065 | - | 6.8 | 180,139 | Common Shares |
| Suzanne L. Bruhn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2025 | 75,187 | 75,187 | - | - | Stock Option (Right to Buy) | |
| Roger Crystal | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2025 | 75,187 | 75,187 | - | - | Stock Option (Right to Buy) | |
| Carol A. Vallone | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2025 | 75,187 | 75,187 | - | - | Stock Option (Right to Buy) | |
| David W. Gryska | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2025 | 75,187 | 75,187 | - | - | Stock Option (Right to Buy) | |
| Andreas Krebs | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2025 | 75,187 | 75,187 | - | - | Stock Option (Right to Buy) | |
| Brandi L. Roberts | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2025 | 500,000 | 500,000 | - | - | Stock Option (Right to Buy) | |
| Mark R. Sullivan | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 6.74 per share. | 25 Mar 2025 | 6,576 | 316,621 | - | 6.7 | 44,322 | Common Shares |
| Robert B. Barrow | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 6.74 per share. | 25 Mar 2025 | 21,208 | 856,556 | - | 6.7 | 142,942 | Common Shares |
| Dan Karlin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 6.74 per share. | 25 Mar 2025 | 6,836 | 446,177 | - | 6.7 | 46,075 | Common Shares |
| Carrie F. Liao | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 6.74 per share. | 25 Mar 2025 | 2,347 | 144,923 | - | 6.7 | 15,819 | Common Shares |
| Matthew T. Wiley | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Mar 2025 | 350,000 | 350,000 | - | - | Stock Option (Right to Buy) | |
| Carrie F. Liao | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Mar 2025 | 50,000 | 142,270 | - | 0 | Common Shares | |
| Dan Karlin | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Mar 2025 | 115,000 | 453,013 | - | 0 | Common Shares | |
| Robert B. Barrow | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Mar 2025 | 350,000 | 877,764 | - | 0 | Common Shares | |
| Mark R. Sullivan | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Mar 2025 | 150,000 | 323,197 | - | 0 | Common Shares | |
| F. Carrie Liao | Chief Accounting Officer | 26 Dec 2024 | 2,273 | 97,270 | - | 7.4 | 16,888 | Common Shares | |
| Dan Karlin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 7.43 per share. | 26 Dec 2024 | 6,643 | 338,013 | - | 7.4 | 49,357 | Common Shares |
| B. Robert Barrow | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 7.43 per share. | 26 Dec 2024 | 19,106 | 526,666 | - | 7.4 | 141,958 | Common Shares |
| Sullivan Mark R. | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 7.43 per share. | 26 Dec 2024 | 4,519 | 173,197 | - | 7.4 | 33,576 | Common Shares |
| W. David Gryska | Director | Purchase of securities on an exchange or from another person at price $ 7.17 per share. | 05 Dec 2024 | 2,500 | 19,851 | - | 7.2 | 17,925 | Common Shares |
| Robert B. Barrow | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 5.98 per share. | 25 Sep 2024 | 19,771 | 545,772 | - | 6.0 | 118,231 | Common Shares |
| Mark R. Sullivan | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 5.98 per share. | 25 Sep 2024 | 4,430 | 177,716 | - | 6.0 | 26,491 | Common Shares |
| Dan Karlin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 5.98 per share. | 25 Sep 2024 | 6,871 | 344,656 | - | 6.0 | 41,089 | Common Shares |
| Carrie F. Liao | Chief Accounting Officer | 25 Sep 2024 | 2,352 | 99,543 | - | 6.0 | 14,065 | Common Shares | |
| David W. Gryska | Director | Purchase of securities on an exchange or from another person at price $ 5.98 per share. | 23 Aug 2024 | 3,500 | 17,351 | - | 6.0 | 20,930 | Common Shares |
| Miri Halperin Wernli | Executive President | 21 Aug 2024 | 50,000 | 235,000 | - | 3.7 | 185,000 | Common Shares | |
| Miri Halperin Wernli | Executive President | 21 Aug 2024 | 32,595 | 202,405 | - | 6.2 | 201,111 | Common Shares | |
| Miri Halperin Wernli | Executive President | 21 Aug 2024 | 50,000 | 0 | - | - | Stock Option (Right to Buy) | ||
| Robert B. Barrow | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 6.31 per share. | 19 Aug 2024 | 500 | 565,043 | - | 6.3 | 3,155 | Common Shares |
| Robert B. Barrow | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 6.12 per share. | 19 Aug 2024 | 500 | 565,543 | - | 6.1 | 3,060 | Common Shares |
| Mark R. Sullivan | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 7.22 per share. | 25 Jun 2024 | 17,854 | 182,146 | - | 7.2 | 128,906 | Common Shares |
| Robert B. Barrow | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 7.22 per share. | 25 Jun 2024 | 15,659 | 564,543 | - | 7.2 | 113,058 | Common Shares |
| Dan Karlin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 7.22 per share. | 25 Jun 2024 | 6,925 | 351,527 | - | 7.2 | 49,999 | Common Shares |
| Suzanne L. Bruhn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2024 | 16,506 | 16,506 | - | - | Stock Option (Right to Buy) | |
| Roger Crystal | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2024 | 16,506 | 16,506 | - | - | Stock Option (Right to Buy) | |
| Carol A. Vallone | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2024 | 16,506 | 16,506 | - | - | Stock Option (Right to Buy) | |
| David W. Gryska | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2024 | 16,506 | 16,506 | - | - | Stock Option (Right to Buy) | |
| Andreas Krebs | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2024 | 16,506 | 16,506 | - | - | Stock Option (Right to Buy) | |
| Dan Karlin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 9.50 per share. | 25 Mar 2024 | 6,578 | 358,452 | - | 9.5 | 62,491 | Common Shares |
| Robert B. Barrow | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 9.50 per share. | 25 Mar 2024 | 16,519 | 580,202 | - | 9.5 | 156,931 | Common Shares |
| Schond L. Greenway | Chief Financial Officer | 25 Mar 2024 | 5,560 | 211,057 | - | 9.8 | 54,377 | Common Shares | |
| Robert B. Barrow | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 400,000 | 400,000 | - | - | Stock Option (Right to Buy) | |
| Dan Karlin | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 150,000 | 150,000 | - | - | Stock Option (Right to Buy) | |
| Greenway L. Schond | Chief Financial Officer | 27 Feb 2024 | 150,000 | 150,000 | - | - | Stock Option (Right to Buy) | ||
| Wernli Miri Halperin | Executive President | 27 Feb 2024 | 125,000 | 125,000 | - | - | Stock Option (Right to Buy) | ||
| Mark R. Sullivan | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 125,000 | 125,000 | - | - | Stock Option (Right to Buy) | |
| Carrie Liao F. | Chief Accounting Officer | 27 Feb 2024 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) |