XNAS 09 Oct, 2026 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Mr. Brian S. Posner | Director | Purchase of securities on an exchange or from another person at price $ 16.00 per share. | 02 Oct 2026 | 2,500 | 27,000 | - | 16 | 40,000 | - |
| Mr. John G. Cox | Director, CEO & President | Sale of securities on an exchange or to another person at price $ 18.88 per share. | 08 Sep 2026 | 5,658 | 357,507 | - | 18.9 | 106,823 | Common Stock |
| Mr. Douglas Kerr, M.D.,PhD | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 24.35 per share. | 04 Sep 2026 | 3,745 | 163,854 | - | 24.4 | 91,191 | Common Stock |
| Mr. Douglas Kerr, M.D.,PhD | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 18.88 per share. | 04 Sep 2026 | 1,290 | 162,564 | - | 18.9 | 24,355 | Common Stock |
| Ms. Johanna Friedl-Naderer | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 18.88 per share. | 04 Sep 2026 | 185 | 152,897 | - | 18.9 | 3,493 | Common Stock |
| Ms. Johanna Friedl-Naderer | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 24.35 per share. | 04 Sep 2026 | 900 | 153,082 | - | 24.4 | 21,915 | Common Stock |
| Mr. Douglas Kerr, M.D.,PhD | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 26.28 per share. | 13 Aug 2026 | 1,556 | 167,599 | - | 26.3 | 40,892 | Common Stock |
| Mr. John G. Cox | Director, CEO & President | Sale of securities on an exchange or to another person at price $ 26.28 per share. | 13 Aug 2026 | 4,986 | 363,165 | - | 26.3 | 131,032 | Common Stock |
| Mr. Erick J. Lucera, C.F.A. | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 26.28 per share. | 13 Aug 2026 | 1,797 | 119,766 | - | 26.3 | 47,225 | Common Stock |
| Ms. Johanna Friedl-Naderer | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 26.28 per share. | 13 Aug 2026 | 226 | 153,982 | - | 26.3 | 5,939 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 26.20 per share. | 13 Aug 2026 | 63,643 | 751,411 | - | 26.2 | 1,667,447 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 26.20 per share. | 13 Aug 2026 | 94,415 | 1,045,735 | - | 26.2 | 2,473,673 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 13 Aug 2026 | 478,377 | 567,358 | - | 25 | 11,959,425 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 26.20 per share. | 13 Aug 2026 | 268,354 | 3,801,128 | - | 26.2 | 7,030,875 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 13 Aug 2026 | 322,465 | 428,946 | - | 25 | 8,061,625 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 13 Aug 2026 | 1,359,674 | 2,441,454 | - | 25 | 33,991,850 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 25.50 per share. | 27 Jul 2026 | 256,072 | 3,592,184 | - | 25.5 | 6,530,451 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 26.04 per share. | 27 Jul 2026 | 5,388 | 3,586,796 | - | 26.0 | 140,319 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 22.79 per share. | 06 Jul 2026 | 253,039 | 4,223,448 | - | 22.8 | 5,766,759 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 23.17 per share. | 06 Jul 2026 | 124,379 | 4,099,069 | - | 23.2 | 2,881,861 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 23.62 per share. | 06 Jul 2026 | 29,587 | 4,069,482 | - | 23.6 | 698,845 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 23.17 per share. | 06 Jul 2026 | 62,543 | 1,154,994 | - | 23.2 | 1,449,121 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 23.62 per share. | 06 Jul 2026 | 14,844 | 1,140,150 | - | 23.6 | 350,615 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 23.17 per share. | 06 Jul 2026 | 49,193 | 826,719 | - | 23.2 | 1,139,802 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 23.62 per share. | 06 Jul 2026 | 11,665 | 815,054 | - | 23.6 | 275,527 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 23.61 per share. | 06 Jul 2026 | 5,000 | 2,962 | - | 23.6 | 118,050 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 22.79 per share. | 06 Jul 2026 | 100,019 | 875,912 | - | 22.8 | 2,279,433 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 22.79 per share. | 06 Jul 2026 | 127,182 | 1,217,537 | - | 22.8 | 2,898,478 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 21.14 per share. | 26 Jun 2026 | 51,756 | 1,344,719 | - | 21.1 | 1,094,122 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 21.14 per share. | 26 Jun 2026 | 102,969 | 4,476,487 | - | 21.1 | 2,176,765 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 21.28 per share. | 26 Jun 2026 | 64,411 | 1,016,633 | - | 21.3 | 1,370,666 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 21.28 per share. | 26 Jun 2026 | 81,903 | 1,396,475 | - | 21.3 | 1,742,896 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 21.28 per share. | 26 Jun 2026 | 162,954 | 4,579,456 | - | 21.3 | 3,467,661 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 21.14 per share. | 26 Jun 2026 | 40,702 | 975,931 | - | 21.1 | 860,440 | Common Stock |
| Mr. Erick J. Lucera, C.F.A. | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 20.37 per share. | 25 Jun 2026 | 2,362 | 121,563 | - | 20.4 | 48,114 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 21.10 per share. | 23 Jun 2026 | 5,019 | 1,081,044 | - | 21.1 | 105,901 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 21.10 per share. | 23 Jun 2026 | 6,382 | 1,478,378 | - | 21.1 | 134,660 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 21.10 per share. | 23 Jun 2026 | 12,699 | 4,742,410 | - | 21.1 | 267,949 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 21.02 per share. | 23 Jun 2026 | 19,973 | 1,086,063 | - | 21.0 | 419,832 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 21.02 per share. | 23 Jun 2026 | 25,397 | 1,484,760 | - | 21.0 | 533,845 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 21.02 per share. | 23 Jun 2026 | 50,530 | 4,755,109 | - | 21.0 | 1,062,141 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 21.13 per share. | 23 Jun 2026 | 30,774 | 1,106,036 | - | 21.1 | 650,255 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 21.13 per share. | 23 Jun 2026 | 77,855 | 4,805,639 | - | 21.1 | 1,645,076 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 21.13 per share. | 23 Jun 2026 | 39,131 | 1,510,157 | - | 21.1 | 826,838 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 21.47 per share. | 22 Jun 2026 | 1,657 | 3,848,256 | - | 21.5 | 35,583 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 20.57 per share. | 22 Jun 2026 | 190,676 | 3,921,542 | - | 20.6 | 3,922,263 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 21.04 per share. | 22 Jun 2026 | 71,629 | 3,849,913 | - | 21.0 | 1,506,766 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 20.07 per share. | 17 Jun 2026 | 46,901 | 4,112,218 | - | 20.1 | 941,373 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 20.14 per share. | 17 Jun 2026 | 37,454 | 4,159,119 | - | 20.1 | 754,316 | Common Stock |
| Mr. Douglas Kerr, M.D.,PhD | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 18.33 per share. | 16 Jun 2026 | 887 | 169,155 | - | 18.3 | 16,259 | Common Stock |
| Mr. John G. Cox | Director, CEO & President | Sale of securities on an exchange or to another person at price $ 18.33 per share. | 16 Jun 2026 | 2,683 | 368,151 | - | 18.3 | 49,179 | Common Stock |
| Ms. Johanna Friedl-Naderer | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 18.33 per share. | 16 Jun 2026 | 145 | 154,208 | - | 18.3 | 2,658 | Common Stock |
| Mr. Brian S. Posner | Director | 05 Jun 2026 | 35,152 | 35,152 | - | - | Stock option (right to buy) | ||
| Mr. Brian S. Posner | Director | Purchase of securities on an exchange or from another person at price $ 16.94 per share. | 05 Jun 2026 | 2,000 | 24,500 | - | 16.9 | 33,880 | Common Stock |
| Mr. Edward M. Hurwitz, J.D. | Director | 05 Jun 2026 | 35,152 | 35,152 | - | - | Stock option (right to buy) | ||
| Mr. David Charles Lubner, C.P.A.,M.S. | Director | 05 Jun 2026 | 35,152 | 35,152 | - | - | Stock option (right to buy) | ||
| Mr. Jason P. Rhodes | Director | 05 Jun 2026 | 35,152 | 35,152 | - | - | Stock option (right to buy) | ||
| Dr. Catherine Stehman-Breen, M.D. | Director | 05 Jun 2026 | 35,152 | 35,152 | - | - | Stock option (right to buy) | ||
| Mr. Dirk Kersten | Director | 05 Jun 2026 | 35,152 | 35,152 | - | - | Stock option (right to buy) | ||
| Dr. Carlo Incerti, M.D. | Director | 05 Jun 2026 | 35,152 | 35,152 | - | - | Stock option (right to buy) | ||
| Mr. Brian S. Posner | Director | Purchase of securities on an exchange or from another person at price $ 17.48 per share. | 03 Jun 2026 | 2,500 | 22,500 | - | 17.5 | 43,700 | Common Stock |
| Mr. Brian S. Posner | Director | Purchase of securities on an exchange or from another person at price $ 18.21 per share. | 26 May 2026 | 2,000 | 20,000 | - | 18.2 | 36,420 | Common Stock |
| Mr. Brian S. Posner | Director | Purchase of securities on an exchange or from another person at price $ 17.12 per share. | 20 May 2026 | 2,500 | 18,000 | - | 17.1 | 42,800 | Common Stock |
| Mr. Douglas Kerr, M.D.,PhD | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 18.36 per share. | 13 May 2026 | 1,564 | 170,042 | - | 18.4 | 28,715 | Common Stock |
| Mr. John G. Cox | Director, CEO & President | Sale of securities on an exchange or to another person at price $ 18.36 per share. | 13 May 2026 | 3,311 | 370,834 | - | 18.4 | 60,790 | Common Stock |
| Mr. Erick J. Lucera, C.F.A. | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 18.36 per share. | 13 May 2026 | 1,448 | 123,925 | - | 18.4 | 26,585 | Common Stock |
| Ms. Johanna Friedl-Naderer | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 18.36 per share. | 13 May 2026 | 228 | 154,353 | - | 18.4 | 4,186 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.18 per share. | 04 May 2026 | 43,621 | 4,883,494 | - | 18.2 | 793,030 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.18 per share. | 04 May 2026 | 21,926 | 1,549,288 | - | 18.2 | 398,615 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.03 per share. | 04 May 2026 | 2,403 | 1,154,054 | - | 18.0 | 43,326 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.03 per share. | 04 May 2026 | 60 | 8,390 | - | 18.0 | 1,082 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.03 per share. | 04 May 2026 | 6,081 | 4,927,115 | - | 18.0 | 109,640 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.03 per share. | 04 May 2026 | 3,056 | 1,571,214 | - | 18.0 | 55,100 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.00 per share. | 04 May 2026 | 2,466 | 1,156,457 | - | 18 | 44,388 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.00 per share. | 04 May 2026 | 61 | 8,450 | - | 18 | 1,098 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.00 per share. | 04 May 2026 | 6,241 | 4,933,196 | - | 18 | 112,338 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.00 per share. | 04 May 2026 | 3,136 | 1,574,270 | - | 18 | 56,448 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.18 per share. | 04 May 2026 | 17,244 | 1,136,810 | - | 18.2 | 313,496 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.18 per share. | 04 May 2026 | 428 | 7,962 | - | 18.2 | 7,781 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.00 per share. | 28 Apr 2026 | 1 | 8,511 | - | 19 | 19 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.00 per share. | 28 Apr 2026 | 26 | 1,577,406 | - | 19 | 494 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.38 per share. | 28 Apr 2026 | 47,082 | 1,158,944 | - | 18.4 | 865,367 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.38 per share. | 28 Apr 2026 | 1,170 | 8,512 | - | 18.4 | 21,505 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.38 per share. | 28 Apr 2026 | 119,115 | 4,939,489 | - | 18.4 | 2,189,334 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.38 per share. | 28 Apr 2026 | 59,870 | 1,577,432 | - | 18.4 | 1,100,411 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.00 per share. | 28 Apr 2026 | 52 | 4,939,437 | - | 19 | 988 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.00 per share. | 28 Apr 2026 | 21 | 1,158,923 | - | 19 | 399 | Common Stock |
| Mr. David Charles Lubner, C.P.A.,M.S. | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 24 Apr 2026 | 53,625 | 0 | - | 0 | Common Stock | |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.48 per share. | 23 Apr 2026 | 710 | 10,576 | - | 18.5 | 13,121 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.48 per share. | 23 Apr 2026 | 72,310 | 5,149,547 | - | 18.5 | 1,336,289 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.48 per share. | 23 Apr 2026 | 36,345 | 1,683,011 | - | 18.5 | 671,656 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.19 per share. | 23 Apr 2026 | 15,148 | 1,270,556 | - | 19.2 | 290,690 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.19 per share. | 23 Apr 2026 | 377 | 11,286 | - | 19.2 | 7,235 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.19 per share. | 23 Apr 2026 | 38,322 | 5,221,857 | - | 19.2 | 735,399 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.19 per share. | 23 Apr 2026 | 19,261 | 1,719,356 | - | 19.2 | 369,619 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.15 per share. | 23 Apr 2026 | 894 | 9,682 | - | 18.1 | 16,226 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.19 per share. | 23 Apr 2026 | 19,261 | 1,719,356 | - | 19.2 | 369,619 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.19 per share. | 23 Apr 2026 | 38,322 | 5,221,857 | - | 19.2 | 735,399 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.19 per share. | 23 Apr 2026 | 377 | 11,286 | - | 19.2 | 7,235 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.19 per share. | 23 Apr 2026 | 15,148 | 1,270,556 | - | 19.2 | 290,690 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.48 per share. | 23 Apr 2026 | 36,345 | 1,683,011 | - | 18.5 | 671,656 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.48 per share. | 23 Apr 2026 | 72,310 | 5,149,547 | - | 18.5 | 1,336,289 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.48 per share. | 23 Apr 2026 | 710 | 10,576 | - | 18.5 | 13,121 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.48 per share. | 23 Apr 2026 | 28,583 | 1,241,973 | - | 18.5 | 528,214 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.15 per share. | 23 Apr 2026 | 45,709 | 1,637,302 | - | 18.1 | 829,618 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.15 per share. | 23 Apr 2026 | 90,943 | 5,058,604 | - | 18.1 | 1,650,615 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.15 per share. | 23 Apr 2026 | 894 | 9,682 | - | 18.1 | 16,226 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.15 per share. | 23 Apr 2026 | 35,947 | 1,206,026 | - | 18.1 | 652,438 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.19 per share. | 23 Apr 2026 | 19,261 | 1,719,356 | - | 19.2 | 369,619 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.19 per share. | 23 Apr 2026 | 38,322 | 5,221,857 | - | 19.2 | 735,399 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.19 per share. | 23 Apr 2026 | 377 | 11,286 | - | 19.2 | 7,235 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.19 per share. | 23 Apr 2026 | 15,148 | 1,270,556 | - | 19.2 | 290,690 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.48 per share. | 23 Apr 2026 | 36,345 | 1,683,011 | - | 18.5 | 671,656 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.48 per share. | 23 Apr 2026 | 72,310 | 5,149,547 | - | 18.5 | 1,336,289 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.48 per share. | 23 Apr 2026 | 710 | 10,576 | - | 18.5 | 13,121 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.48 per share. | 23 Apr 2026 | 28,583 | 1,241,973 | - | 18.5 | 528,214 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.15 per share. | 23 Apr 2026 | 45,709 | 1,637,302 | - | 18.1 | 829,618 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.15 per share. | 23 Apr 2026 | 90,943 | 5,058,604 | - | 18.1 | 1,650,615 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.15 per share. | 23 Apr 2026 | 894 | 9,682 | - | 18.1 | 16,226 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.15 per share. | 23 Apr 2026 | 35,947 | 1,206,026 | - | 18.1 | 652,438 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.15 per share. | 23 Apr 2026 | 35,947 | 1,206,026 | - | 18.1 | 652,438 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.15 per share. | 23 Apr 2026 | 90,943 | 5,058,604 | - | 18.1 | 1,650,615 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.15 per share. | 23 Apr 2026 | 45,709 | 1,637,302 | - | 18.1 | 829,618 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 18.48 per share. | 23 Apr 2026 | 28,583 | 1,241,973 | - | 18.5 | 528,214 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 20.01 per share. | 21 Apr 2026 | 8,300 | 4,199,225 | - | 20.0 | 166,120 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 20.00 per share. | 21 Apr 2026 | 2,652 | 4,196,573 | - | 20.0 | 53,049 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 20.01 per share. | 21 Apr 2026 | 8,300 | 4,199,225 | - | 20.0 | 166,120 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 20.00 per share. | 21 Apr 2026 | 2,652 | 4,196,573 | - | 20.0 | 53,049 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 20.01 per share. | 21 Apr 2026 | 8,300 | 4,199,225 | - | 20.0 | 166,120 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 20.00 per share. | 21 Apr 2026 | 2,652 | 4,196,573 | - | 20.0 | 53,049 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.06 per share. | 20 Apr 2026 | 71,676 | 1,886,751 | - | 20.1 | 1,437,821 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.06 per share. | 20 Apr 2026 | 142,604 | 5,554,904 | - | 20.1 | 2,860,636 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.06 per share. | 20 Apr 2026 | 1,401 | 14,561 | - | 20.1 | 28,104 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.06 per share. | 20 Apr 2026 | 56,368 | 1,402,200 | - | 20.1 | 1,130,742 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.51 per share. | 20 Apr 2026 | 71,499 | 1,815,252 | - | 19.5 | 1,394,945 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.51 per share. | 20 Apr 2026 | 142,253 | 5,412,651 | - | 19.5 | 2,775,356 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.51 per share. | 20 Apr 2026 | 1,398 | 13,163 | - | 19.5 | 27,275 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.51 per share. | 20 Apr 2026 | 56,228 | 1,345,972 | - | 19.5 | 1,097,008 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.05 per share. | 20 Apr 2026 | 769 | 1,814,483 | - | 20.0 | 15,418 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.05 per share. | 20 Apr 2026 | 1,530 | 5,411,121 | - | 20.1 | 30,677 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.07 per share. | 20 Apr 2026 | 15 | 13,148 | - | 20.1 | 301 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.05 per share. | 20 Apr 2026 | 605 | 1,345,367 | - | 20.0 | 12,130 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.68 per share. | 20 Apr 2026 | 75,866 | 1,738,617 | - | 19.7 | 1,493,043 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.68 per share. | 20 Apr 2026 | 150,942 | 5,260,179 | - | 19.7 | 2,970,539 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.68 per share. | 20 Apr 2026 | 1,485 | 11,663 | - | 19.7 | 29,225 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.68 per share. | 20 Apr 2026 | 59,663 | 1,285,704 | - | 19.7 | 1,174,168 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.06 per share. | 20 Apr 2026 | 71,676 | 1,886,751 | - | 20.1 | 1,437,821 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.06 per share. | 20 Apr 2026 | 142,604 | 5,554,904 | - | 20.1 | 2,860,636 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.06 per share. | 20 Apr 2026 | 1,401 | 14,561 | - | 20.1 | 28,104 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.06 per share. | 20 Apr 2026 | 56,368 | 1,402,200 | - | 20.1 | 1,130,742 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.51 per share. | 20 Apr 2026 | 71,499 | 1,815,252 | - | 19.5 | 1,394,945 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.51 per share. | 20 Apr 2026 | 142,253 | 5,412,651 | - | 19.5 | 2,775,356 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.51 per share. | 20 Apr 2026 | 1,398 | 13,163 | - | 19.5 | 27,275 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.51 per share. | 20 Apr 2026 | 56,228 | 1,345,972 | - | 19.5 | 1,097,008 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.05 per share. | 20 Apr 2026 | 769 | 1,814,483 | - | 20.0 | 15,418 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.05 per share. | 20 Apr 2026 | 1,530 | 5,411,121 | - | 20.1 | 30,677 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.07 per share. | 20 Apr 2026 | 15 | 13,148 | - | 20.1 | 301 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.05 per share. | 20 Apr 2026 | 605 | 1,345,367 | - | 20.0 | 12,130 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.68 per share. | 20 Apr 2026 | 75,866 | 1,738,617 | - | 19.7 | 1,493,043 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.68 per share. | 20 Apr 2026 | 150,942 | 5,260,179 | - | 19.7 | 2,970,539 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.68 per share. | 20 Apr 2026 | 1,485 | 11,663 | - | 19.7 | 29,225 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.68 per share. | 20 Apr 2026 | 59,663 | 1,285,704 | - | 19.7 | 1,174,168 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.06 per share. | 20 Apr 2026 | 71,676 | 1,886,751 | - | 20.1 | 1,437,821 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.68 per share. | 20 Apr 2026 | 59,663 | 1,285,704 | - | 19.7 | 1,174,168 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.68 per share. | 20 Apr 2026 | 1,485 | 11,663 | - | 19.7 | 29,225 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.68 per share. | 20 Apr 2026 | 150,942 | 5,260,179 | - | 19.7 | 2,970,539 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.68 per share. | 20 Apr 2026 | 75,866 | 1,738,617 | - | 19.7 | 1,493,043 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.05 per share. | 20 Apr 2026 | 605 | 1,345,367 | - | 20.0 | 12,130 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.07 per share. | 20 Apr 2026 | 15 | 13,148 | - | 20.1 | 301 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.05 per share. | 20 Apr 2026 | 1,530 | 5,411,121 | - | 20.1 | 30,677 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.05 per share. | 20 Apr 2026 | 769 | 1,814,483 | - | 20.0 | 15,418 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.51 per share. | 20 Apr 2026 | 56,228 | 1,345,972 | - | 19.5 | 1,097,008 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.51 per share. | 20 Apr 2026 | 1,398 | 13,163 | - | 19.5 | 27,275 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.51 per share. | 20 Apr 2026 | 142,253 | 5,412,651 | - | 19.5 | 2,775,356 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 19.51 per share. | 20 Apr 2026 | 71,499 | 1,815,252 | - | 19.5 | 1,394,945 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.06 per share. | 20 Apr 2026 | 56,368 | 1,402,200 | - | 20.1 | 1,130,742 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.06 per share. | 20 Apr 2026 | 1,401 | 14,561 | - | 20.1 | 28,104 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 20.06 per share. | 20 Apr 2026 | 142,604 | 5,554,904 | - | 20.1 | 2,860,636 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 20.07 per share. | 17 Apr 2026 | 125,274 | 4,207,525 | - | 20.1 | 2,513,898 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 20.29 per share. | 17 Apr 2026 | 211,974 | 4,332,799 | - | 20.3 | 4,301,292 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 20.29 per share. | 17 Apr 2026 | 211,974 | 4,332,799 | - | 20.3 | 4,301,292 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 20.07 per share. | 17 Apr 2026 | 125,274 | 4,207,525 | - | 20.1 | 2,513,898 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 20.29 per share. | 17 Apr 2026 | 211,974 | 4,332,799 | - | 20.3 | 4,301,292 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 20.07 per share. | 17 Apr 2026 | 125,274 | 4,207,525 | - | 20.1 | 2,513,898 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 20.27 per share. | 15 Apr 2026 | 81,840 | 4,562,546 | - | 20.3 | 1,659,044 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 21.10 per share. | 15 Apr 2026 | 11,116 | 4,551,430 | - | 21.1 | 234,591 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 20.06 per share. | 15 Apr 2026 | 6,657 | 4,544,773 | - | 20.1 | 133,523 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 20.27 per share. | 15 Apr 2026 | 81,840 | 4,562,546 | - | 20.3 | 1,659,044 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 21.10 per share. | 15 Apr 2026 | 11,116 | 4,551,430 | - | 21.1 | 234,591 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 20.06 per share. | 15 Apr 2026 | 6,657 | 4,544,773 | - | 20.1 | 133,523 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 21.10 per share. | 15 Apr 2026 | 11,116 | 4,551,430 | - | 21.1 | 234,591 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 20.27 per share. | 15 Apr 2026 | 81,840 | 4,562,546 | - | 20.3 | 1,659,044 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 20.06 per share. | 15 Apr 2026 | 6,657 | 4,544,773 | - | 20.1 | 133,523 | Common Stock |
| Mr. Erick J. Lucera, C.F.A. | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 18.64 per share. | 01 Apr 2026 | 5,727 | 125,373 | - | 18.6 | 106,751 | Common Stock |
| Mr. Brian S. Posner | Director | Purchase of securities on an exchange or from another person at price $ 17.08 per share. | 30 Mar 2026 | 2,000 | 15,500 | - | 17.1 | 34,160 | Common Stock |
| Mr. Brian S. Posner | Director | Purchase of securities on an exchange or from another person at price $ 19.35 per share. | 11 Mar 2026 | 2,000 | 13,500 | - | 19.4 | 38,700 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 19.52 per share. | 11 Mar 2026 | 129,672 | 4,644,386 | - | 19.5 | 2,530,562 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 19.52 per share. | 11 Mar 2026 | 129,672 | 4,644,386 | - | 19.5 | 2,530,562 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 19.52 per share. | 11 Mar 2026 | 129,672 | 4,644,386 | - | 19.5 | 2,530,562 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 17.72 per share. | 09 Mar 2026 | 177,690 | 5,285,156 | - | 17.7 | 3,148,987 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 18.21 per share. | 09 Mar 2026 | 9,482 | 5,275,674 | - | 18.2 | 172,687 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 19.32 per share. | 09 Mar 2026 | 219,758 | 5,055,916 | - | 19.3 | 4,246,823 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 19.80 per share. | 09 Mar 2026 | 281,858 | 4,774,058 | - | 19.8 | 5,580,817 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 17.72 per share. | 09 Mar 2026 | 177,690 | 5,285,156 | - | 17.7 | 3,148,987 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 18.21 per share. | 09 Mar 2026 | 9,482 | 5,275,674 | - | 18.2 | 172,687 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 19.32 per share. | 09 Mar 2026 | 219,758 | 5,055,916 | - | 19.3 | 4,246,823 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 19.80 per share. | 09 Mar 2026 | 281,858 | 4,774,058 | - | 19.8 | 5,580,817 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 19.80 per share. | 09 Mar 2026 | 281,858 | 4,774,058 | - | 19.8 | 5,580,817 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 19.32 per share. | 09 Mar 2026 | 219,758 | 5,055,916 | - | 19.3 | 4,246,823 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 18.21 per share. | 09 Mar 2026 | 9,482 | 5,275,674 | - | 18.2 | 172,687 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 17.72 per share. | 09 Mar 2026 | 177,690 | 5,285,156 | - | 17.7 | 3,148,987 | Common Stock |
| Mr. Brian S. Posner | Director | Purchase of securities on an exchange or from another person at price $ 15.06 per share. | 06 Mar 2026 | 3,000 | 11,500 | - | 15.1 | 45,180 | Common Stock |
| Mr. Douglas Kerr, M.D.,PhD | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 14.90 per share. | 05 Mar 2026 | 904 | 171,606 | - | 14.9 | 13,470 | Common Stock |
| Mr. John G. Cox | Director, CEO & President | Sale of securities on an exchange or to another person at price $ 14.90 per share. | 05 Mar 2026 | 2,732 | 374,145 | - | 14.9 | 40,707 | Common Stock |
| Ms. Johanna Friedl-Naderer | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 14.90 per share. | 05 Mar 2026 | 148 | 154,581 | - | 14.9 | 2,205 | Common Stock |
| Mr. Douglas Kerr, M.D.,PhD | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2026 | 85,000 | 172,510 | - | 0 | Common Stock | |
| Mr. Douglas Kerr, M.D.,PhD | Chief Medical Officer | 12 Feb 2026 | 130,000 | 130,000 | - | - | Stock option (right to buy) | ||
| Mr. John G. Cox | Director, CEO & President | 12 Feb 2026 | 285,000 | 285,000 | - | - | Stock option (right to buy) | ||
| Mr. John G. Cox | Director, CEO & President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2026 | 180,000 | 376,877 | - | 0 | Common Stock | |
| Mr. Erick J. Lucera, C.F.A. | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2026 | 65,000 | 131,100 | - | 0 | Common Stock | |
| Mr. Erick J. Lucera, C.F.A. | Chief Financial Officer | 12 Feb 2026 | 105,000 | 105,000 | - | - | Stock Option (Right to Buy) | ||
| Ms. Johanna Friedl-Naderer | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2026 | 60,000 | 154,729 | - | 0 | Common Stock | |
| Ms. Johanna Friedl-Naderer | Chief Commercial Officer | 12 Feb 2026 | 90,000 | 90,000 | - | - | Stock option (right to buy) | ||
| Mr. Douglas Kerr, M.D.,PhD | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 20.72 per share. | 05 Dec 2025 | 880 | 87,510 | - | 20.7 | 18,234 | Common Stock |
| Mr. John G. Cox | Director, CEO & President | Sale of securities on an exchange or to another person at price $ 20.72 per share. | 05 Dec 2025 | 2,662 | 196,877 | - | 20.7 | 55,157 | Common Stock |
| Ms. Johanna Friedl-Naderer | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 20.72 per share. | 05 Dec 2025 | 144 | 94,729 | - | 20.7 | 2,984 | Common Stock |
| Mr. Brian S. Posner | Director | 01 Oct 2025 | 70,000 | 70,000 | - | - | Stock option (right to buy) | ||
| Mr. John G. Cox | Director, CEO & President | Sale of securities on an exchange or to another person at price $ 13.41 per share. | 05 Sep 2025 | 2,640 | 199,539 | - | 13.4 | 35,402 | Common Stock |
| Ms. Johanna Friedl-Naderer | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 13.41 per share. | 04 Sep 2025 | 144 | 94,873 | - | 13.4 | 1,931 | Common Stock |
| Ms. Johanna Friedl-Naderer | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 13.27 per share. | 04 Sep 2025 | 894 | 95,017 | - | 13.3 | 11,863 | Common Stock |
| Mr. Douglas Kerr, M.D.,PhD | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 13.41 per share. | 04 Sep 2025 | 873 | 88,390 | - | 13.4 | 11,707 | Common Stock |
| Mr. Douglas Kerr, M.D.,PhD | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 13.27 per share. | 04 Sep 2025 | 3,552 | 89,263 | - | 13.3 | 47,135 | Common Stock |
| Mr. Douglas Kerr, M.D.,PhD | Chief Medical Officer | 16 Jul 2025 | 65,110 | 65,110 | - | - | Stock option (right to buy) | ||
| Mr. John G. Cox | Director, CEO & President | 16 Jul 2025 | 197,285 | 197,285 | - | - | Stock option (right to buy) | ||
| Ms. Johanna Friedl-Naderer | Chief Commercial Officer | 16 Jul 2025 | 51,255 | 51,255 | - | - | Stock option (right to buy) | ||
| John G. Cox | Director, CEO & President | Purchase of securities on an exchange or from another person at price $ 9.11 per share. | 14 Jul 2025 | 100,000 | 242,179 | - | 9.1 | 911,000 | Common Stock |
| John G. Cox | Director, CEO & President | Gift of securities by or to the insider at price $ 0.00 per share. | 14 Jul 2025 | 10,000 | 202,179 | - | 0 | Common Stock | |
| John G. Cox | Director, CEO & President | Gift of securities by or to the insider at price $ 0.00 per share. | 14 Jul 2025 | 10,000 | 212,179 | - | 0 | Common Stock | |
| John G. Cox | Director, CEO & President | Gift of securities by or to the insider at price $ 0.00 per share. | 14 Jul 2025 | 10,000 | 222,179 | - | 0 | Common Stock | |
| John G. Cox | Director, CEO & President | Gift of securities by or to the insider at price $ 0.00 per share. | 14 Jul 2025 | 10,000 | 232,179 | - | 0 | Common Stock | |
| Mr. Douglas Kerr, M.D.,PhD | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 13.35 per share. | 05 Jun 2025 | 1,342 | 92,815 | - | 13.4 | 17,916 | Common Stock |
| Mr. John G. Cox | Director, CEO & President | Sale of securities on an exchange or to another person at price $ 13.35 per share. | 05 Jun 2025 | 4,060 | 142,179 | - | 13.4 | 54,201 | Common Stock |
| Ms. Johanna Friedl-Naderer | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 13.35 per share. | 05 Jun 2025 | 146 | 95,911 | - | 13.3 | 1,949 | Common Stock |
| Mr. Edward M. Hurwitz, J.D. | Director | 30 May 2025 | 35,000 | 35,000 | - | - | Stock option (right to buy) | ||
| Mr. David Charles Lubner, C.P.A.,M.S. | Director | 30 May 2025 | 35,000 | 35,000 | - | - | Stock option (right to buy) | ||
| Mr. Jason P. Rhodes | Director | 30 May 2025 | 35,000 | 35,000 | - | - | Stock option (right to buy) | ||
| Dr. Catherine Stehman-Breen, M.D. | Director | 30 May 2025 | 35,000 | 35,000 | - | - | Stock option (right to buy) | ||
| Mr. Dirk Kersten | Director | 30 May 2025 | 35,000 | 35,000 | - | - | Stock option (right to buy) | ||
| Dr. Carlo Incerti, M.D. | Director | 30 May 2025 | 35,000 | 35,000 | - | - | Stock option (right to buy) | ||
| Mr. Erick J. Lucera, C.F.A. | Chief Financial Officer | 31 Mar 2025 | 214,500 | 214,500 | - | - | Stock Option (Right to Buy) | ||
| Mr. Erick J. Lucera, C.F.A. | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2025 | 66,100 | 66,100 | - | 0 | Common Stock | |
| Ms. Johanna Friedl-Naderer | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 12.12 per share. | 13 Mar 2025 | 143 | 96,057 | - | 12.1 | 1,733 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 11.38 per share. | 11 Mar 2025 | 1,343 | 122,330 | - | 11.4 | 15,283 | Common Stock |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 11.38 per share. | 11 Mar 2025 | 2,153 | 195,840 | - | 11.4 | 24,501 | Common Stock |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 11.38 per share. | 11 Mar 2025 | 2,153 | 195,840 | - | 11.4 | 24,501 | - |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 11.38 per share. | 11 Mar 2025 | 1,343 | 122,330 | - | 11.4 | 15,283 | - |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 11.38 per share. | 11 Mar 2025 | 2,153 | 195,840 | - | 11.4 | 24,501 | - |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 11.38 per share. | 11 Mar 2025 | 1,343 | 122,330 | - | 11.4 | 15,283 | - |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 11.83 per share. | 05 Mar 2025 | 1,094 | 197,993 | - | 11.8 | 12,942 | - |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 11.83 per share. | 05 Mar 2025 | 917 | 123,673 | - | 11.8 | 10,848 | - |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 11.83 per share. | 05 Mar 2025 | 1,094 | 197,993 | - | 11.8 | 12,942 | - |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 11.83 per share. | 05 Mar 2025 | 917 | 123,673 | - | 11.8 | 10,848 | - |
| Mr. John G. Cox | Director, CEO & President | Sale of securities on an exchange or to another person at price $ 11.83 per share. | 05 Mar 2025 | 4,061 | 146,239 | - | 11.8 | 48,042 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 11.83 per share. | 05 Mar 2025 | 917 | 123,673 | - | 11.8 | 10,848 | Common Stock |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 11.83 per share. | 05 Mar 2025 | 1,094 | 197,993 | - | 11.8 | 12,942 | Common Stock |
| Mr. Douglas Kerr, M.D.,PhD | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 11.83 per share. | 05 Mar 2025 | 1,343 | 94,157 | - | 11.8 | 15,888 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 13.95 per share. | 18 Feb 2025 | 2,488 | 124,590 | - | 14.0 | 34,708 | Common Stock |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 13.95 per share. | 18 Feb 2025 | 2,598 | 199,087 | - | 13.9 | 36,242 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 13.95 per share. | 18 Feb 2025 | 2,488 | 124,590 | - | 14.0 | 34,708 | - |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 13.95 per share. | 18 Feb 2025 | 2,598 | 199,087 | - | 13.9 | 36,242 | - |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 13.95 per share. | 18 Feb 2025 | 2,488 | 124,590 | - | 14.0 | 34,708 | - |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 13.95 per share. | 18 Feb 2025 | 2,598 | 199,087 | - | 13.9 | 36,242 | - |
| Mr. Jason P. Rhodes | Director | Grant, award, or other acquisition of securities at price $ 13.50 per share. | 27 Jan 2025 | 1,111,111 | 1,958,427 | - | 13.5 | 14,999,999 | - |
| Mr. Jason P. Rhodes | Director | Grant, award, or other acquisition of securities at price $ 13.50 per share. | 27 Jan 2025 | 1,111,111 | 1,958,427 | - | 13.5 | 14,999,999 | - |
| Mr. Jason P. Rhodes | Director | Grant, award, or other acquisition of securities at price $ 13.50 per share. | 27 Jan 2025 | 1,111,111 | 1,958,427 | - | 13.5 | 14,999,999 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 28.12 per share. | 11 Dec 2024 | 1,455 | 127,078 | - | 28.1 | 40,915 | Common Stock |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 28.12 per share. | 11 Dec 2024 | 2,334 | 201,685 | - | 28.1 | 65,632 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 29.34 per share. | 06 Dec 2024 | 101,675 | 5,434,982 | - | 29.3 | 2,983,145 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 29.18 per share. | 06 Dec 2024 | 34,437 | 5,400,545 | - | 29.2 | 1,004,872 | Common Stock |
| Mr. John G. Cox | Director, CEO & President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Dec 2024 | 145,300 | 150,300 | - | 0 | Common Stock | |
| Mr. John G. Cox | Director, CEO & President | 04 Dec 2024 | 232,100 | 232,100 | - | - | Stock option (right to buy) | ||
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Dec 2024 | 32,700 | 128,533 | - | 0 | Common Stock | |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | 04 Dec 2024 | 52,300 | 52,300 | - | - | Stock option (right to buy) | ||
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Dec 2024 | 27,400 | 204,019 | - | 0 | Common Stock | |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | 04 Dec 2024 | 62,400 | 62,400 | - | - | Stock option (right to buy) | ||
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Dec 2024 | 39,100 | 176,619 | - | 0 | Common Stock | |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 29.39 per share. | 04 Dec 2024 | 135,039 | 5,540,463 | - | 29.4 | 3,968,796 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 29.05 per share. | 04 Dec 2024 | 3,806 | 5,536,657 | - | 29.0 | 110,564 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 30.37 per share. | 02 Dec 2024 | 1,228 | 5,705,234 | - | 30.4 | 37,294 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 29.05 per share. | 02 Dec 2024 | 29,732 | 5,675,502 | - | 29.1 | 863,715 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 29.66 per share. | 02 Dec 2024 | 79,973 | 5,706,462 | - | 29.7 | 2,371,999 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 28.20 per share. | 18 Nov 2024 | 2,735 | 95,833 | - | 28.2 | 77,127 | Common Stock |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 28.20 per share. | 18 Nov 2024 | 2,856 | 137,519 | - | 28.2 | 80,539 | Common Stock |
| Dr. Carlo Incerti | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.69 per share. | 18 Nov 2024 | 16,500 | 16,500 | - | 8.7 | 143,385 | Common Stock |
| Dr. Carlo Incerti | Director | 18 Nov 2024 | 16,500 | 22,693 | - | - | Stock option (right to buy) | ||
| Dr. Carlo Incerti | Director | Sale of securities on an exchange or to another person at price $ 28.73 per share. | 18 Nov 2024 | 16,500 | 0 | - | 28.7 | 474,045 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 33.10 per share. | 14 Nov 2024 | 583 | 5,697,508 | - | 33.1 | 19,297 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 33.10 per share. | 14 Nov 2024 | 123 | 1,458,568 | - | 33.1 | 4,071 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 33.10 per share. | 14 Nov 2024 | 72 | 847,316 | - | 33.1 | 2,383 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 33.00 per share. | 14 Nov 2024 | 4 | 15,962 | - | 33 | 132 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 32.82 per share. | 13 Nov 2024 | 8,929 | 5,786,435 | - | 32.8 | 293,050 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 35.24 per share. | 13 Nov 2024 | 10,803 | 62,301 | - | 35.2 | 380,698 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 35.06 per share. | 18 Oct 2024 | 121 | 73,104 | - | 35.1 | 4,242 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 35.16 per share. | 18 Oct 2024 | 13,414 | 73,225 | - | 35.2 | 471,636 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 35.17 per share. | 16 Oct 2024 | 13,013 | 86,639 | - | 35.2 | 457,667 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 35.35 per share. | 16 Oct 2024 | 23,671 | 99,652 | - | 35.4 | 836,770 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 35.13 per share. | 03 Oct 2024 | 5,441 | 123,323 | - | 35.1 | 191,142 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 35.16 per share. | 01 Oct 2024 | 8,423 | 150,282 | - | 35.2 | 296,153 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 35.38 per share. | 01 Oct 2024 | 21,518 | 128,764 | - | 35.4 | 761,307 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 35.47 per share. | 27 Sep 2024 | 29,007 | 160,640 | - | 35.5 | 1,028,878 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 36.02 per share. | 27 Sep 2024 | 1,935 | 158,705 | - | 36.0 | 69,699 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 35.00 per share. | 27 Sep 2024 | 32 | 189,647 | - | 35 | 1,120 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 35.29 per share. | 25 Sep 2024 | 1,260 | 189,679 | - | 35.3 | 44,465 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 35.06 per share. | 25 Sep 2024 | 2,357 | 190,939 | - | 35.1 | 82,636 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 36.45 per share. | 20 Sep 2024 | 78,940 | 234,598 | - | 36.5 | 2,877,363 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 36.33 per share. | 20 Sep 2024 | 4,610 | 193,296 | - | 36.3 | 167,481 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 35.19 per share. | 20 Sep 2024 | 36,221 | 197,906 | - | 35.2 | 1,274,617 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 37.01 per share. | 20 Sep 2024 | 471 | 234,127 | - | 37.0 | 17,432 | Common Stock |
| Ms. Susanna High | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 34.41 per share. | 18 Sep 2024 | 4,636 | 131,636 | - | 34.4 | 159,525 | Common Stock |
| Ms. Susanna High | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 34.41 per share. | 18 Sep 2024 | 4,340 | 136,272 | - | 34.4 | 149,339 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 34.55 per share. | 18 Sep 2024 | 1,390 | 98,568 | - | 34.6 | 48,025 | Common Stock |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 34.55 per share. | 18 Sep 2024 | 2,339 | 140,375 | - | 34.5 | 80,812 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 36.41 per share. | 18 Sep 2024 | 50,972 | 313,538 | - | 36.4 | 1,855,891 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 35.74 per share. | 18 Sep 2024 | 27,767 | 364,510 | - | 35.7 | 992,393 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 35.03 per share. | 18 Sep 2024 | 1,554 | 392,277 | - | 35.0 | 54,437 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 35.13 per share. | 16 Sep 2024 | 3,272 | 393,831 | - | 35.1 | 114,945 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 35.04 per share. | 16 Sep 2024 | 1,320 | 397,103 | - | 35.0 | 46,253 | Common Stock |
| Ms. Susanna High | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 31.89 per share. | 11 Sep 2024 | 2,722 | 140,612 | - | 31.9 | 86,805 | Common Stock |
| Ms. Susanna High | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 31.89 per share. | 11 Sep 2024 | 2,548 | 143,334 | - | 31.9 | 81,256 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 31.89 per share. | 11 Sep 2024 | 1,468 | 99,958 | - | 31.9 | 46,815 | Common Stock |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 31.89 per share. | 11 Sep 2024 | 2,161 | 142,714 | - | 31.9 | 68,914 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.54 per share. | 06 Sep 2024 | 6,502 | 117,524 | - | 5.5 | 36,021 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.88 per share. | 06 Sep 2024 | 6,552 | 227,500 | - | 10.9 | 71,286 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 32.14 per share. | 06 Sep 2024 | 124,374 | 103,126 | - | 32.1 | 3,997,380 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 32.63 per share. | 06 Sep 2024 | 1,700 | 101,426 | - | 32.6 | 55,471 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | 06 Sep 2024 | 6,502 | 0 | - | - | Stock option (right to buy) | ||
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | 06 Sep 2024 | 3,353 | 0 | - | - | Stock option (right to buy) | ||
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | 06 Sep 2024 | 34,833 | 742 | - | - | Stock option (right to buy) | ||
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | 06 Sep 2024 | 16,696 | 8,348 | - | - | Stock option (right to buy) | ||
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | 06 Sep 2024 | 29,792 | 25,208 | - | - | Stock option (right to buy) | ||
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | 06 Sep 2024 | 18,750 | 26,250 | - | - | Stock option (right to buy) | ||
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | 06 Sep 2024 | 6,552 | 28,394 | - | - | Stock option (right to buy) | ||
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.72 per share. | 06 Sep 2024 | 18,750 | 220,948 | - | 10.7 | 201,000 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.58 per share. | 06 Sep 2024 | 29,792 | 202,198 | - | 8.6 | 255,615 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.12 per share. | 06 Sep 2024 | 16,696 | 172,406 | - | 13.1 | 219,052 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.00 per share. | 06 Sep 2024 | 34,833 | 155,710 | - | 19 | 661,827 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.54 per share. | 06 Sep 2024 | 3,353 | 120,877 | - | 5.5 | 18,576 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 35.03 per share. | 05 Sep 2024 | 1,577 | 398,423 | - | 35.0 | 55,242 | Common Stock |
| Mr. John G. Cox | Director, CEO & President | Purchase of securities on an exchange or from another person at price $ 32.57 per share. | 04 Sep 2024 | 800 | 800 | - | 32.6 | 26,056 | Common Stock |
| Mr. John G. Cox | Director, CEO & President | Purchase of securities on an exchange or from another person at price $ 32.57 per share. | 04 Sep 2024 | 800 | 800 | - | 32.6 | 26,056 | Common Stock |
| Mr. John G. Cox | Director, CEO & President | Purchase of securities on an exchange or from another person at price $ 33.09 per share. | 04 Sep 2024 | 7,200 | 8,000 | - | 33.1 | 238,248 | Common Stock |
| Mr. John G. Cox | Director, CEO & President | Purchase of securities on an exchange or from another person at price $ 33.09 per share. | 04 Sep 2024 | 7,200 | 8,000 | - | 33.1 | 238,248 | Common Stock |
| Mr. John G. Cox | Director, CEO & President | Purchase of securities on an exchange or from another person at price $ 32.57 per share. | 04 Sep 2024 | 800 | 800 | - | 32.6 | 26,056 | Common Stock |
| Mr. John G. Cox | Director, CEO & President | Purchase of securities on an exchange or from another person at price $ 33.09 per share. | 04 Sep 2024 | 7,200 | 8,000 | - | 33.1 | 238,248 | Common Stock |
| Mr. John G. Cox | Director, CEO & President | Purchase of securities on an exchange or from another person at price $ 32.57 per share. | 04 Sep 2024 | 800 | 800 | - | 32.6 | 26,056 | Common Stock |
| Mr. John G. Cox | Director, CEO & President | Purchase of securities on an exchange or from another person at price $ 33.09 per share. | 04 Sep 2024 | 7,200 | 8,000 | - | 33.1 | 238,248 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 46.01 per share. | 30 Aug 2024 | 6,204 | 400,000 | - | 46.0 | 285,446 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 45.49 per share. | 30 Aug 2024 | 25,096 | 406,204 | - | 45.5 | 1,141,617 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 44.41 per share. | 28 Aug 2024 | 16,386 | 549,175 | - | 44.4 | 727,702 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 45.81 per share. | 28 Aug 2024 | 10,768 | 431,300 | - | 45.8 | 493,282 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 45.19 per share. | 28 Aug 2024 | 45,640 | 442,068 | - | 45.2 | 2,062,472 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 44.94 per share. | 28 Aug 2024 | 61,467 | 487,708 | - | 44.9 | 2,762,327 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 45.23 per share. | 26 Aug 2024 | 77,963 | 642,498 | - | 45.2 | 3,526,266 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 44.28 per share. | 26 Aug 2024 | 65,403 | 565,561 | - | 44.3 | 2,896,045 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 45.79 per share. | 26 Aug 2024 | 11,534 | 630,964 | - | 45.8 | 528,142 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 46.37 per share. | 22 Aug 2024 | 64,133 | 720,461 | - | 46.4 | 2,973,847 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 45.82 per share. | 22 Aug 2024 | 20,955 | 784,594 | - | 45.8 | 960,158 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 46.97 per share. | 22 Aug 2024 | 413 | 805,549 | - | 47.0 | 19,399 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 45.82 per share. | 22 Aug 2024 | 94,908 | 805,962 | - | 45.8 | 4,348,685 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 45.68 per share. | 20 Aug 2024 | 43,057 | 1,080,416 | - | 45.7 | 1,966,844 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 47.01 per share. | 20 Aug 2024 | 71,245 | 900,870 | - | 47.0 | 3,349,227 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 46.52 per share. | 20 Aug 2024 | 64,518 | 972,115 | - | 46.5 | 3,001,377 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 47.30 per share. | 20 Aug 2024 | 8,326 | 1,036,633 | - | 47.3 | 393,820 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 46.94 per share. | 20 Aug 2024 | 35,457 | 1,044,959 | - | 46.9 | 1,664,352 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 45.01 per share. | 19 Aug 2024 | 2,442 | 111,332 | - | 45.0 | 109,914 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 46.00 per share. | 19 Aug 2024 | 310 | 111,022 | - | 46 | 14,260 | Common Stock |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 46.00 per share. | 19 Aug 2024 | 296 | 144,875 | - | 46 | 13,616 | Common Stock |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 45.01 per share. | 19 Aug 2024 | 2,340 | 145,171 | - | 45.0 | 105,323 | Common Stock |
| Mr. Wildon Farwell, M.D.,M.P.H. | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 46.00 per share. | 19 Aug 2024 | 261 | 143,222 | - | 46 | 12,006 | Common Stock |
| Mr. Wildon Farwell, M.D.,M.P.H. | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 45.01 per share. | 19 Aug 2024 | 2,060 | 143,483 | - | 45.0 | 92,721 | Common Stock |
| Ms. Susanna High | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 45.01 per share. | 19 Aug 2024 | 2,582 | 146,210 | - | 45.0 | 116,216 | - |
| Ms. Susanna High | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 46.00 per share. | 19 Aug 2024 | 328 | 145,882 | - | 46 | 15,088 | - |
| Dr. Jonathan McNeill, M.D. | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 46.00 per share. | 19 Aug 2024 | 305 | 132,106 | - | 46 | 14,030 | - |
| Dr. Jonathan McNeill, M.D. | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 45.01 per share. | 19 Aug 2024 | 2,400 | 132,411 | - | 45.0 | 108,024 | - |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 45.35 per share. | 16 Aug 2024 | 85,086 | 1,252,577 | - | 45.3 | 3,858,650 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 46.59 per share. | 16 Aug 2024 | 5,760 | 1,123,473 | - | 46.6 | 268,358 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 46.01 per share. | 16 Aug 2024 | 89,824 | 1,129,233 | - | 46.0 | 4,132,802 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 45.10 per share. | 16 Aug 2024 | 30,448 | 1,219,057 | - | 45.1 | 1,373,205 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 46.19 per share. | 16 Aug 2024 | 3,072 | 1,249,505 | - | 46.2 | 141,896 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 44.52 per share. | 16 Aug 2024 | 34,485 | 1,337,663 | - | 44.5 | 1,535,272 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 45.67 per share. | 14 Aug 2024 | 49,601 | 1,372,148 | - | 45.7 | 2,265,278 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 45.25 per share. | 14 Aug 2024 | 131,290 | 1,421,749 | - | 45.3 | 5,940,873 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 43.67 per share. | 14 Aug 2024 | 100,650 | 1,553,039 | - | 43.7 | 4,395,386 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 43.57 per share. | 12 Aug 2024 | 21,428 | 1,653,689 | - | 43.6 | 933,618 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 42.78 per share. | 12 Aug 2024 | 88,179 | 1,675,117 | - | 42.8 | 3,772,298 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 42.08 per share. | 12 Aug 2024 | 24,378 | 1,763,296 | - | 42.1 | 1,025,826 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 43.42 per share. | 12 Aug 2024 | 52,076 | 1,787,674 | - | 43.4 | 2,261,140 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 42.74 per share. | 12 Aug 2024 | 26,416 | 1,839,750 | - | 42.7 | 1,129,020 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 40.74 per share. | 08 Aug 2024 | 6,377 | 6,410,416 | - | 40.7 | 259,799 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 44.04 per share. | 08 Aug 2024 | 1,160 | 6,232,959 | - | 44.0 | 51,086 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 43.44 per share. | 08 Aug 2024 | 40,268 | 6,234,119 | - | 43.4 | 1,749,242 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 42.55 per share. | 08 Aug 2024 | 50,736 | 6,274,387 | - | 42.6 | 2,158,817 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 42.87 per share. | 08 Aug 2024 | 68,936 | 6,325,123 | - | 42.9 | 2,955,286 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 42.97 per share. | 08 Aug 2024 | 16,357 | 6,394,059 | - | 43.0 | 702,860 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 40.74 per share. | 08 Aug 2024 | 6,377 | 2,043,623 | - | 40.7 | 259,799 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 42.97 per share. | 08 Aug 2024 | 16,357 | 2,027,266 | - | 43.0 | 702,860 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 44.04 per share. | 08 Aug 2024 | 1,160 | 1,866,166 | - | 44.0 | 51,086 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 43.44 per share. | 08 Aug 2024 | 40,268 | 1,867,326 | - | 43.4 | 1,749,242 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 42.55 per share. | 08 Aug 2024 | 50,736 | 1,907,594 | - | 42.6 | 2,158,817 | Common Stock |
| Mr. Dirk Kersten | Director | Sale of securities on an exchange or to another person at price $ 42.87 per share. | 08 Aug 2024 | 68,936 | 1,958,330 | - | 42.9 | 2,955,286 | Common Stock |
| Ms. Susanna High | Chief Operating Officer | 21 Jun 2024 | 10,163 | 60,536 | - | - | Stock option (right to buy) | ||
| Ms. Susanna High | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.54 per share. | 21 Jun 2024 | 29,787 | 178,579 | - | 5.5 | 165,020 | Common Stock |
| Ms. Susanna High | Chief Operating Officer | 21 Jun 2024 | 29,787 | 70,699 | - | - | Stock option (right to buy) | ||
| Ms. Susanna High | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 35.33 per share. | 21 Jun 2024 | 10,163 | 148,792 | - | 35.3 | 359,059 | Common Stock |
| Ms. Susanna High | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.54 per share. | 21 Jun 2024 | 10,163 | 158,955 | - | 5.5 | 56,303 | Common Stock |
| Ms. Susanna High | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 35.01 per share. | 21 Jun 2024 | 29,787 | 148,792 | - | 35.0 | 1,042,843 | Common Stock |
| Ms. Susanna High | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.54 per share. | 21 Jun 2024 | 29,787 | 178,579 | - | 5.5 | 165,020 | - |
| Ms. Susanna High | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 35.33 per share. | 21 Jun 2024 | 10,213 | 148,792 | - | 35.3 | 360,825 | - |
| Ms. Susanna High | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.54 per share. | 21 Jun 2024 | 10,213 | 159,005 | - | 5.5 | 56,580 | - |
| Ms. Susanna High | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 35.01 per share. | 21 Jun 2024 | 29,787 | 148,792 | - | 35.0 | 1,042,843 | - |
| Ms. Susanna High | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.54 per share. | 12 Jun 2024 | 40,000 | 188,792 | - | 5.5 | 221,600 | - |
| Ms. Susanna High | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 33.17 per share. | 12 Jun 2024 | 26,036 | 162,756 | - | 33.2 | 863,614 | - |
| Ms. Susanna High | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 33.70 per share. | 12 Jun 2024 | 13,964 | 148,792 | - | 33.7 | 470,587 | - |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 31.34 per share. | 11 Jun 2024 | 2,136 | 147,511 | - | 31.3 | 66,942 | Common Stock |
| Mr. Wildon Farwell, M.D.,M.P.H. | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 31.27 per share. | 11 Jun 2024 | 1,628 | 146,551 | - | 31.3 | 50,908 | Common Stock |
| Mr. Wildon Farwell, M.D.,M.P.H. | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 31.27 per share. | 11 Jun 2024 | 1,008 | 145,543 | - | 31.3 | 31,520 | Common Stock |
| Dr. Jonathan McNeill, M.D. | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 31.34 per share. | 11 Jun 2024 | 1,823 | 134,811 | - | 31.3 | 57,133 | - |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 31.34 per share. | 10 Jun 2024 | 1,331 | 113,774 | - | 31.3 | 41,714 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 30.23 per share. | 10 Jun 2024 | 1,590 | 115,105 | - | 30.2 | 48,066 | Common Stock |
| Ms. Susanna High | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.54 per share. | 10 Jun 2024 | 80,000 | 234,062 | - | 5.5 | 443,200 | - |
| Ms. Susanna High | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 30.24 per share. | 10 Jun 2024 | 80,000 | 154,062 | - | 30.2 | 2,419,200 | - |
| Ms. Susanna High | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 31.23 per share. | 10 Jun 2024 | 2,357 | 151,705 | - | 31.2 | 73,609 | - |
| Ms. Susanna High | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 31.23 per share. | 10 Jun 2024 | 2,913 | 148,792 | - | 31.2 | 90,973 | - |
| Mr. Edward M. Hurwitz, J.D. | Director | 22 May 2024 | 25,133 | 25,133 | - | - | Stock option (right to buy) | ||
| Mr. David Charles Lubner, C.P.A.,M.S. | Director | 22 May 2024 | 25,133 | 25,133 | - | - | Stock option (right to buy) | ||
| Mr. Jason P. Rhodes | Director | 22 May 2024 | 25,133 | 25,133 | - | - | Stock option (right to buy) | ||
| Dr. Catherine Stehman-Breen, M.D. | Director | 22 May 2024 | 25,133 | 25,133 | - | - | Stock option (right to buy) | ||
| Mr. Dirk Kersten | Director | 22 May 2024 | 25,133 | 25,133 | - | - | Stock option (right to buy) | ||
| Dr. Carlo Incerti | Director | 22 May 2024 | 25,133 | 25,133 | - | - | Stock option (right to buy) | ||
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 33.51 per share. | 20 May 2024 | 12,147 | 150,792 | - | 33.5 | 407,046 | Common Stock |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 32.49 per share. | 20 May 2024 | 17,134 | 162,939 | - | 32.5 | 556,684 | Common Stock |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.03 per share. | 20 May 2024 | 30,426 | 180,073 | - | 1.0 | 31,339 | Common Stock |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | 20 May 2024 | 30,426 | 0 | - | - | Stock option (right to buy) | ||
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 34.08 per share. | 20 May 2024 | 1,145 | 149,647 | - | 34.1 | 39,022 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 28.20 per share. | 16 May 2024 | 2,126 | 117,157 | - | 28.2 | 59,953 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 28.59 per share. | 16 May 2024 | 462 | 116,695 | - | 28.6 | 13,209 | Common Stock |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 28.59 per share. | 16 May 2024 | 483 | 149,647 | - | 28.6 | 13,809 | Common Stock |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 28.20 per share. | 16 May 2024 | 2,222 | 150,130 | - | 28.2 | 62,660 | Common Stock |
| Mr. Wildon Farwell, M.D.,M.P.H. | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 28.59 per share. | 16 May 2024 | 425 | 148,179 | - | 28.6 | 12,151 | Common Stock |
| Mr. Wildon Farwell, M.D.,M.P.H. | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 28.20 per share. | 16 May 2024 | 1,956 | 148,604 | - | 28.2 | 55,159 | Common Stock |
| Ms. Susanna High | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 28.59 per share. | 16 May 2024 | 489 | 154,062 | - | 28.6 | 13,981 | - |
| Ms. Susanna High | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 28.20 per share. | 16 May 2024 | 2,249 | 154,551 | - | 28.2 | 63,422 | - |
| Dr. Jonathan McNeill, M.D. | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 28.20 per share. | 16 May 2024 | 2,279 | 137,129 | - | 28.2 | 64,268 | - |
| Dr. Jonathan McNeill, M.D. | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 28.59 per share. | 16 May 2024 | 495 | 136,634 | - | 28.6 | 14,152 | - |
| Mr. John G. Cox | Director, See Remarks | 25 Mar 2024 | 679,853 | 679,853 | - | - | Stock Option (Right to Buy) | ||
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 25.70 per share. | 11 Mar 2024 | 2,081 | 152,352 | - | 25.7 | 53,482 | Common Stock |
| Mr. Wildon Farwell, M.D.,M.P.H. | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 25.70 per share. | 11 Mar 2024 | 1,585 | 151,590 | - | 25.7 | 40,735 | Common Stock |
| Mr. Wildon Farwell, M.D.,M.P.H. | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 25.58 per share. | 11 Mar 2024 | 1,030 | 150,560 | - | 25.6 | 26,347 | Common Stock |
| Mr. Joshua T. Brumm | Director, CEO & President | Sale of securities on an exchange or to another person at price $ 26.10 per share. | 08 Mar 2024 | 9,928 | 554,385 | - | 26.1 | 259,121 | Common Stock |
| Mr. Joshua T. Brumm | Director, CEO & President | Sale of securities on an exchange or to another person at price $ 25.42 per share. | 08 Mar 2024 | 40,072 | 564,313 | - | 25.4 | 1,018,630 | Common Stock |
| Mr. Joshua T. Brumm | Director, CEO & President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.54 per share. | 08 Mar 2024 | 50,000 | 604,385 | - | 5.5 | 277,000 | Common Stock |
| Mr. Joshua T. Brumm | Director, CEO & President | Sale of securities on an exchange or to another person at price $ 27.38 per share. | 08 Mar 2024 | 435 | 554,385 | - | 27.4 | 11,910 | Common Stock |
| Mr. Joshua T. Brumm | Director, CEO & President | Sale of securities on an exchange or to another person at price $ 26.72 per share. | 08 Mar 2024 | 160,670 | 554,820 | - | 26.7 | 4,293,102 | Common Stock |
| Mr. Joshua T. Brumm | Director, CEO & President | Sale of securities on an exchange or to another person at price $ 25.30 per share. | 08 Mar 2024 | 202,238 | 715,490 | - | 25.3 | 5,116,621 | Common Stock |
| Mr. Joshua T. Brumm | Director, CEO & President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.54 per share. | 08 Mar 2024 | 209,412 | 917,728 | - | 5.5 | 1,160,142 | Common Stock |
| Mr. Joshua T. Brumm | Director, CEO & President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.54 per share. | 08 Mar 2024 | 153,931 | 708,316 | - | 5.5 | 852,778 | Common Stock |
| Mr. Joshua T. Brumm | Director, CEO & President | 08 Mar 2024 | 153,931 | 0 | - | - | Stock option (right to buy) | ||
| Mr. Joshua T. Brumm | Director, CEO & President | Sale of securities on an exchange or to another person at price $ 25.93 per share. | 08 Mar 2024 | 8,618 | 537,998 | - | 25.9 | 223,465 | Common Stock |
| Mr. Joshua T. Brumm | Director, CEO & President | Sale of securities on an exchange or to another person at price $ 26.12 per share. | 08 Mar 2024 | 7,769 | 546,616 | - | 26.1 | 202,926 | Common Stock |
| Mr. Joshua T. Brumm | Director, CEO & President | 08 Mar 2024 | 50,000 | 83,269 | - | - | Stock option (right to buy) | ||
| Mr. Joshua T. Brumm | Director, CEO & President | 08 Mar 2024 | 209,412 | 133,269 | - | - | Stock option (right to buy) | ||
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 24.99 per share. | 08 Mar 2024 | 1,590 | 119,283 | - | 25.0 | 39,734 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 25.70 per share. | 08 Mar 2024 | 1,082 | 120,873 | - | 25.7 | 27,807 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 27.33 per share. | 08 Mar 2024 | 289 | 121,955 | - | 27.3 | 7,898 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 26.72 per share. | 08 Mar 2024 | 55,208 | 122,244 | - | 26.7 | 1,475,158 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 25.31 per share. | 08 Mar 2024 | 30,755 | 177,452 | - | 25.3 | 778,409 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.54 per share. | 08 Mar 2024 | 17,333 | 208,207 | - | 5.5 | 96,025 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.54 per share. | 08 Mar 2024 | 68,919 | 190,874 | - | 5.5 | 381,811 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | 08 Mar 2024 | 17,333 | 0 | - | - | Stock option (right to buy) | ||
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | 08 Mar 2024 | 68,919 | 9,855 | - | - | Stock option (right to buy) | ||
| Ms. Susanna High | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 25.70 per share. | 08 Mar 2024 | 2,292 | 156,800 | - | 25.7 | 58,904 | - |
| Ms. Susanna High | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 26.66 per share. | 08 Mar 2024 | 26,908 | 159,383 | - | 26.7 | 717,367 | - |
| Ms. Susanna High | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 27.41 per share. | 08 Mar 2024 | 291 | 159,092 | - | 27.4 | 7,976 | - |
| Dr. Jonathan McNeill, M.D. | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.54 per share. | 08 Mar 2024 | 17,825 | 159,009 | - | 5.5 | 98,751 | - |
| Dr. Jonathan McNeill, M.D. | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 25.71 per share. | 08 Mar 2024 | 1,776 | 139,408 | - | 25.7 | 45,661 | - |
| Dr. Jonathan McNeill, M.D. | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 25.48 per share. | 08 Mar 2024 | 17,825 | 141,184 | - | 25.5 | 454,181 | - |
| Dr. Jonathan McNeill, M.D. | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 27.31 per share. | 08 Mar 2024 | 689 | 141,184 | - | 27.3 | 18,817 | - |
| Dr. Jonathan McNeill, M.D. | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 26.72 per share. | 08 Mar 2024 | 54,648 | 141,873 | - | 26.7 | 1,460,195 | - |
| Dr. Jonathan McNeill, M.D. | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 25.46 per share. | 08 Mar 2024 | 34,663 | 196,521 | - | 25.5 | 882,520 | - |
| Dr. Jonathan McNeill, M.D. | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.54 per share. | 08 Mar 2024 | 3,841 | 231,184 | - | 5.5 | 21,279 | - |
| Dr. Jonathan McNeill, M.D. | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.54 per share. | 08 Mar 2024 | 86,159 | 227,343 | - | 5.5 | 477,321 | - |
| Mr. Joshua T. Brumm | Director, CEO & President | Sale of securities on an exchange or to another person at price $ 25.85 per share. | 07 Mar 2024 | 9,086 | 554,385 | - | 25.8 | 234,873 | Common Stock |
| Mr. Richard William Scalzo | SVP, Head of Finance & Admin. | Sale of securities on an exchange or to another person at price $ 25.85 per share. | 07 Mar 2024 | 2,273 | 121,955 | - | 25.8 | 58,757 | Common Stock |
| Dr. Oxana Beskrovnaya, PhD | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 25.85 per share. | 07 Mar 2024 | 2,373 | 154,433 | - | 25.8 | 61,342 | Common Stock |
| Mr. Wildon Farwell, M.D.,M.P.H. | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 26.20 per share. | 07 Mar 2024 | 1,557 | 153,175 | - | 26.2 | 40,793 | Common Stock |
| Mr. Wildon Farwell, M.D.,M.P.H. | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 25.80 per share. | 07 Mar 2024 | 8,364 | 154,732 | - | 25.8 | 215,791 | Common Stock |
| Ms. Susanna High | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 25.85 per share. | 07 Mar 2024 | 1,591 | 186,291 | - | 25.8 | 41,127 | - |
| Dr. Jonathan McNeill, M.D. | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 25.85 per share. | 07 Mar 2024 | 2,434 | 141,184 | - | 25.9 | 62,919 | - |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 30.05 per share. | 01 Mar 2024 | 29,435 | 1,458,691 | - | 30.1 | 884,522 | Common Stock |
| Mr. Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 30.05 per share. | 01 Mar 2024 | 17,099 | 847,388 | - | 30.1 | 513,825 | Common Stock |