XNAS 08 Oct, 2026 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Mr. Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 147.72 per share. | 01 Oct 2026 | 12,000 | 569,683 (0%) | 0% | 147.7 | 1,772,628 | - |
| Mr. Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 148.63 per share. | 01 Oct 2026 | 3,000 | 566,683 (0%) | 0% | 148.6 | 445,880 | - |
| Ms. Erin Burkhart | SVP, Controllership | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Sep 2026 | 2,223 | 2,223 (0%) | 0% | - | - | |
| Ms. Erin Burkhart | SVP, Controllership | Payment of exercise price or tax liability using portion of securities received from the company at price $ 152.67 per share. | 22 Sep 2026 | 768 | 1,455 (0%) | 0% | 152.7 | 117,251 | - |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 145.29 per share. | 15 Sep 2026 | 3,000 | 164,096 (0%) | 0% | 145.3 | 435,870 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Sale of securities on an exchange or to another person at price $ 145.29 per share. | 15 Sep 2026 | 600 | 116,684 (0%) | 0% | 145.3 | 87,174 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Sale of securities on an exchange or to another person at price $ 144.46 per share. | 15 Sep 2026 | 800 | 117,284 (0%) | 0% | 144.5 | 115,566 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Sale of securities on an exchange or to another person at price $ 143.69 per share. | 15 Sep 2026 | 1,600 | 118,084 (0%) | 0% | 143.7 | 229,907 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2026 | 2,797 | 25,054 | - | - | Restricted Stock Unit | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2026 | 2,797 | 168,443 (0%) | 0% | - | Common Stock | |
| Andrew D. Dickinson | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 144.81 per share. | 10 Sep 2026 | 1,347 | 167,096 (0%) | 0% | 144.8 | 195,059 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 144.81 per share. | 10 Sep 2026 | 4,230 | 581,683 (0%) | 0% | 144.8 | 612,546 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2026 | 8,780 | 83,300 | - | - | Restricted Stock Unit | |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2026 | 8,780 | 585,913 (0%) | 0% | - | Common Stock | |
| Dietmar Berger | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2026 | 533 | 46,395 | - | - | Restricted Stock Unit | |
| Dietmar Berger | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2026 | 533 | 19,785 (0%) | 0% | - | Common Stock | |
| Dietmar Berger | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 144.81 per share. | 10 Sep 2026 | 263 | 19,522 (0%) | 0% | 144.8 | 38,085 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2026 | 2,797 | 25,054 | - | - | Restricted Stock Unit | |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 144.81 per share. | 10 Sep 2026 | 1,347 | 119,684 (0%) | 0% | 144.8 | 195,059 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2026 | 2,797 | 121,031 (0%) | 0% | - | Common Stock | |
| Wettan Keeley M Cain | EVP Gen Counsel, Legal & Comp | Payment of exercise price or tax liability using portion of securities received from the company at price $ 144.81 per share. | 10 Sep 2026 | 285 | 8,759 (0%) | 0% | 144.8 | 41,271 | Common Stock |
| Wettan Keeley M Cain | EVP Gen Counsel, Legal & Comp | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2026 | 590 | 13,405 | - | - | Restricted Stock Unit | |
| Wettan Keeley M Cain | EVP Gen Counsel, Legal & Comp | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2026 | 590 | 9,044 (0%) | 0% | - | Common Stock | |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 149.38 per share. | 01 Sep 2026 | 5,408 | 577,133 (0%) | 0% | 149.4 | 807,856 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 148.36 per share. | 01 Sep 2026 | 7,992 | 582,541 (0%) | 0% | 148.4 | 1,185,722 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 147.51 per share. | 01 Sep 2026 | 1,600 | 590,533 (0%) | 0% | 147.5 | 236,014 | Common Stock |
| Anthony Welters | Director | Sale of securities on an exchange or to another person at price $ 148.24 per share. | 26 Aug 2026 | 3,402 | 19,774 (0%) | 0% | 148.2 | 504,296 | Common Stock |
| Anthony Welters | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 61.35 per share. | 26 Aug 2026 | 10,282 | 23,176 (0%) | 0% | 61.4 | 630,801 | Common Stock |
| Anthony Welters | Director | Sale of securities on an exchange or to another person at price $ 148.82 per share. | 26 Aug 2026 | 4,600 | 12,894 (0%) | 0% | 148.8 | 684,590 | Common Stock |
| Anthony Welters | Director | Sale of securities on an exchange or to another person at price $ 148.31 per share. | 26 Aug 2026 | 3,118 | 17,494 (0%) | 0% | 148.3 | 462,432 | Common Stock |
| Anthony Welters | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.67 per share. | 26 Aug 2026 | 7,718 | 20,612 (0%) | 0% | 60.7 | 468,251 | Common Stock |
| Anthony Welters | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Aug 2026 | 10,282 | 5,569 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Anthony Welters | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Aug 2026 | 7,718 | 0 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Anthony Welters | Director | Sale of securities on an exchange or to another person at price $ 148.82 per share. | 26 Aug 2026 | 6,880 | 12,894 (0%) | 0% | 148.8 | 1,023,900 | Common Stock |
| Jeffrey A. Bluestone | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.45 per share. | 20 Aug 2026 | 1,165 | 11,231 (0%) | 0% | 67.4 | 78,579 | Common Stock |
| Jeffrey A. Bluestone | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Aug 2026 | 335 | 11,395 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Jeffrey A. Bluestone | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Aug 2026 | 4,665 | 0 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Jeffrey A. Bluestone | Director | Sale of securities on an exchange or to another person at price $ 146.26 per share. | 20 Aug 2026 | 335 | 10,066 (0%) | 0% | 146.3 | 48,997 | Common Stock |
| Jeffrey A. Bluestone | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 61.35 per share. | 20 Aug 2026 | 335 | 10,401 (0%) | 0% | 61.3 | 20,552 | Common Stock |
| Jeffrey A. Bluestone | Director | Sale of securities on an exchange or to another person at price $ 146.35 per share. | 20 Aug 2026 | 26 | 10,066 (0%) | 0% | 146.3 | 3,805 | Common Stock |
| Jeffrey A. Bluestone | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.46 per share. | 20 Aug 2026 | 26 | 10,092 (0%) | 0% | 67.5 | 1,754 | Common Stock |
| Jeffrey A. Bluestone | Director | Sale of securities on an exchange or to another person at price $ 145.73 per share. | 20 Aug 2026 | 1,658 | 10,066 (0%) | 0% | 145.7 | 241,618 | Common Stock |
| Jeffrey A. Bluestone | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.45 per share. | 20 Aug 2026 | 1,658 | 11,724 (0%) | 0% | 67.4 | 111,832 | Common Stock |
| Jeffrey A. Bluestone | Director | Sale of securities on an exchange or to another person at price $ 144.92 per share. | 20 Aug 2026 | 1,816 | 10,066 (0%) | 0% | 144.9 | 263,183 | Common Stock |
| Jeffrey A. Bluestone | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.45 per share. | 20 Aug 2026 | 1,816 | 11,882 (0%) | 0% | 67.4 | 122,489 | Common Stock |
| Jeffrey A. Bluestone | Director | Sale of securities on an exchange or to another person at price $ 143.75 per share. | 20 Aug 2026 | 1,165 | 10,066 (0%) | 0% | 143.8 | 167,474 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 138.36 per share. | 17 Aug 2026 | 3,000 | 165,646 (0%) | 0% | 138.4 | 415,080 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Aug 2026 | 1,890 | 69,960 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.64 per share. | 17 Aug 2026 | 23,110 | 144,344 (0%) | 0% | 66.6 | 1,540,050 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Sale of securities on an exchange or to another person at price $ 138.04 per share. | 17 Aug 2026 | 11,470 | 118,234 (0%) | 0% | 138.0 | 1,583,265 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Sale of securities on an exchange or to another person at price $ 137.36 per share. | 17 Aug 2026 | 16,530 | 129,704 (0%) | 0% | 137.4 | 2,270,643 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 72.34 per share. | 17 Aug 2026 | 1,890 | 146,234 (0%) | 0% | 72.3 | 136,723 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Aug 2026 | 23,110 | 0 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Wettan Keeley M Cain | EVP Gen Counsel, Legal & Comp | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Aug 2026 | 6,002 | 13,995 | - | - | Restricted Stock Unit | |
| Wettan Keeley M Cain | EVP Gen Counsel, Legal & Comp | Payment of exercise price or tax liability using portion of securities received from the company at price $ 133.06 per share. | 10 Aug 2026 | 2,908 | 8,454 (0%) | 0% | 133.1 | 386,938 | Common Stock |
| Wettan Keeley M Cain | EVP Gen Counsel, Legal & Comp | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Aug 2026 | 6,002 | 11,362 (0%) | 0% | - | Common Stock | |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 131.34 per share. | 03 Aug 2026 | 600 | 592,133 (0%) | 0% | 131.3 | 78,806 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 130.80 per share. | 03 Aug 2026 | 7,700 | 592,733 (0%) | 0% | 130.8 | 1,007,177 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 129.66 per share. | 03 Aug 2026 | 6,700 | 600,433 (0%) | 0% | 129.7 | 868,711 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 129.93 per share. | 15 Jul 2026 | 3,000 | 168,646 (0%) | 0% | 129.9 | 389,777 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Sale of securities on an exchange or to another person at price $ 129.92 per share. | 15 Jul 2026 | 3,000 | 121,234 (0%) | 0% | 129.9 | 389,758 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 126.09 per share. | 01 Jul 2026 | 11,900 | 610,233 (0%) | 0% | 126.1 | 1,500,467 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 127.08 per share. | 01 Jul 2026 | 3,100 | 607,133 (0%) | 0% | 127.1 | 393,933 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 125.40 per share. | 15 Jun 2026 | 3,000 | 171,646 (0%) | 0% | 125.4 | 376,200 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Sale of securities on an exchange or to another person at price $ 124.00 per share. | 15 Jun 2026 | 1,070 | 124,684 (0%) | 0% | 124.0 | 132,676 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Sale of securities on an exchange or to another person at price $ 125.40 per share. | 15 Jun 2026 | 450 | 124,234 (0%) | 0% | 125.4 | 56,430 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Sale of securities on an exchange or to another person at price $ 123.42 per share. | 15 Jun 2026 | 1,480 | 125,754 (0%) | 0% | 123.4 | 182,657 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2026 | 2,796 | 27,851 | - | - | Restricted Stock Unit | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2026 | 2,796 | 175,987 (0%) | 0% | - | Common Stock | |
| Andrew D. Dickinson | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 121.48 per share. | 10 Jun 2026 | 1,341 | 174,646 (0%) | 0% | 121.5 | 162,905 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 121.48 per share. | 10 Jun 2026 | 4,213 | 622,133 (0%) | 0% | 121.5 | 511,795 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2026 | 8,779 | 626,346 (0%) | 0% | - | Common Stock | |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2026 | 8,779 | 92,080 | - | - | Restricted Stock Unit | |
| Dietmar Berger | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 121.48 per share. | 10 Jun 2026 | 263 | 19,252 (0%) | 0% | 121.5 | 31,949 | Common Stock |
| Dietmar Berger | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2026 | 533 | 46,928 | - | - | Restricted Stock Unit | |
| Dietmar Berger | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2026 | 533 | 19,515 (0%) | 0% | - | Common Stock | |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2026 | 2,796 | 128,575 (0%) | 0% | - | Common Stock | |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2026 | 2,796 | 27,851 | - | - | Restricted Stock Unit | |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 121.48 per share. | 10 Jun 2026 | 1,341 | 127,234 (0%) | 0% | 121.5 | 162,905 | Common Stock |
| Wettan Keeley M Cain | EVP Gen Counsel, Legal & Comp | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2026 | 589 | 19,997 | - | - | Restricted Stock Unit | |
| Wettan Keeley M Cain | EVP Gen Counsel, Legal & Comp | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2026 | 589 | 5,643 (0%) | 0% | - | Common Stock | |
| Wettan Keeley M Cain | EVP Gen Counsel, Legal & Comp | Payment of exercise price or tax liability using portion of securities received from the company at price $ 121.48 per share. | 10 Jun 2026 | 283 | 5,360 (0%) | 0% | 121.5 | 34,379 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 132.22 per share. | 01 Jun 2026 | 3,062 | 618,605 (0%) | 0% | 132.2 | 404,843 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 131.10 per share. | 01 Jun 2026 | 10,900 | 621,667 (0%) | 0% | 131.1 | 1,428,983 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 132.97 per share. | 01 Jun 2026 | 1,038 | 617,567 (0%) | 0% | 133.0 | 138,021 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 132.27 per share. | 15 May 2026 | 3,000 | 173,191 (0%) | 0% | 132.3 | 396,810 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 May 2026 | 25,000 | 23,110 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Sale of securities on an exchange or to another person at price $ 132.75 per share. | 15 May 2026 | 700 | 125,779 (0%) | 0% | 132.8 | 92,926 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Sale of securities on an exchange or to another person at price $ 132.23 per share. | 15 May 2026 | 8,374 | 126,479 (0%) | 0% | 132.2 | 1,107,314 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Sale of securities on an exchange or to another person at price $ 130.29 per share. | 15 May 2026 | 7,749 | 146,030 (0%) | 0% | 130.3 | 1,009,629 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.64 per share. | 15 May 2026 | 25,000 | 153,779 (0%) | 0% | 66.6 | 1,666,000 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Sale of securities on an exchange or to another person at price $ 131.19 per share. | 15 May 2026 | 11,177 | 134,853 (0%) | 0% | 131.2 | 1,466,330 | Common Stock |
| Kelly Anne Kramer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2026 | 1,146 | 20,256 | - | - | Restricted Stock Unit | |
| Kelly Anne Kramer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2026 | 4,884 | 4,884 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Anthony Welters | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2026 | 1,146 | 12,894 (0%) | 0% | 0 | Common Stock | |
| Anthony Welters | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2026 | 4,884 | 4,884 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Jacqueline K. Barton | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2026 | 1,146 | 27,202 (0%) | 0% | 0 | Common Stock | |
| Jacqueline K. Barton | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2026 | 4,884 | 4,884 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Javier J. Rodriguez | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2026 | 4,884 | 4,884 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Javier J. Rodriguez | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2026 | 1,146 | 13,364 (0%) | 0% | 0 | Common Stock | |
| Ted W. Love | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2026 | 1,146 | 5,484 (0%) | 0% | 0 | Common Stock | |
| Ted W. Love | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2026 | 4,884 | 4,884 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Harish Manwani | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2026 | 4,884 | 4,884 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Harish Manwani | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 130.84 per share. | 30 Apr 2026 | 224 | 15,015 (0%) | 0% | 130.8 | 29,308 | Common Stock |
| Harish Manwani | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2026 | 1,146 | 15,239 (0%) | 0% | 0 | Common Stock | |
| Sandra J. Horning | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2026 | 4,884 | 4,884 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Sandra J. Horning | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2026 | 1,146 | 6,293 (0%) | 0% | 0 | Common Stock | |
| Jeffrey A. Bluestone | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2026 | 1,146 | 10,066 (0%) | 0% | 0 | Common Stock | |
| Jeffrey A. Bluestone | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Apr 2026 | 4,884 | 4,884 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 130.01 per share. | 28 Apr 2026 | 3,050 | 632,567 (0%) | 0% | 130.0 | 396,534 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 128.79 per share. | 28 Apr 2026 | 6,950 | 635,617 (0%) | 0% | 128.8 | 895,075 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 140.96 per share. | 15 Apr 2026 | 3,000 | 176,191 (0%) | 0% | 141.0 | 422,880 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Sale of securities on an exchange or to another person at price $ 140.96 per share. | 15 Apr 2026 | 3,000 | 128,779 (0%) | 0% | 141.0 | 422,880 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 136.82 per share. | 27 Mar 2026 | 10,000 | 642,567 (0%) | 0% | 136.8 | 1,368,162 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 144.23 per share. | 16 Mar 2026 | 3,000 | 179,191 (0%) | 0% | 144.2 | 432,690 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Sale of securities on an exchange or to another person at price $ 144.23 per share. | 16 Mar 2026 | 3,000 | 131,779 (0%) | 0% | 144.2 | 432,690 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2026 | 6,469 | 185,338 (0%) | 0% | - | Common Stock | |
| Andrew D. Dickinson | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 148.56 per share. | 10 Mar 2026 | 3,147 | 182,191 (0%) | 0% | 148.6 | 467,518 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2026 | 6,469 | 21,057 | - | - | Restricted Stock Unit | |
| Andrew D. Dickinson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 9,590 | 30,647 | - | - | Restricted Stock Unit | |
| Andrew D. Dickinson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 35,880 | 35,880 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Daniel P. O'Day | Director, Chairman & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 148.56 per share. | 10 Mar 2026 | 9,767 | 652,567 (0%) | 0% | 148.6 | 1,450,986 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 122,755 | 122,755 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Daniel P. O'Day | Director, Chairman & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 32,815 | 100,859 | - | - | Restricted Stock Unit | |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2026 | 20,026 | 68,044 | - | - | Restricted Stock Unit | |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2026 | 20,026 | 662,334 (0%) | 0% | - | Common Stock | |
| Dietmar Berger | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 31,475 | 31,475 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Dietmar Berger | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 148.56 per share. | 10 Mar 2026 | 1,063 | 18,982 (0%) | 0% | 148.6 | 157,919 | Common Stock |
| Dietmar Berger | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2026 | 2,133 | 39,046 | - | - | Restricted Stock Unit | |
| Dietmar Berger | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 8,415 | 47,461 | - | - | Restricted Stock Unit | |
| Dietmar Berger | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2026 | 2,133 | 20,045 (0%) | 0% | - | Common Stock | |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2026 | 6,617 | 137,995 (0%) | 0% | - | Common Stock | |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2026 | 6,617 | 21,057 | - | - | Restricted Stock Unit | |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 148.56 per share. | 10 Mar 2026 | 3,216 | 134,779 (0%) | 0% | 148.6 | 477,769 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 35,880 | 35,880 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 9,590 | 30,647 | - | - | Restricted Stock Unit | |
| Erin Burkhart | SVP, Controllership | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 5,455 | 5,455 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Erin Burkhart | SVP, Controllership | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 2,355 | 11,245 | - | - | Restricted Stock Unit | |
| Wettan Keeley M Cain | EVP Gen Counsel, Legal & Comp | Payment of exercise price or tax liability using portion of securities received from the company at price $ 148.56 per share. | 10 Mar 2026 | 606 | 5,054 (0%) | 0% | 148.6 | 90,027 | Common Stock |
| Wettan Keeley M Cain | EVP Gen Counsel, Legal & Comp | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 18,885 | 18,885 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Wettan Keeley M Cain | EVP Gen Counsel, Legal & Comp | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 5,050 | 20,586 | - | - | Restricted Stock Unit | |
| Wettan Keeley M Cain | EVP Gen Counsel, Legal & Comp | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2026 | 1,246 | 15,536 | - | - | Restricted Stock Unit | |
| Wettan Keeley M Cain | EVP Gen Counsel, Legal & Comp | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2026 | 1,246 | 5,660 (0%) | 0% | - | Common Stock | |
| Andrew D. Dickinson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2026 | 11,090 | 178,869 (0%) | 0% | 0 | Common Stock | |
| Daniel P. O'Day | Director, Chairman & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2026 | 38,396 | 652,308 (0%) | 0% | 0 | Common Stock | |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 145.71 per share. | 27 Feb 2026 | 100 | 642,308 (0%) | 0% | 145.7 | 14,571 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 145.18 per share. | 27 Feb 2026 | 6,419 | 642,408 (0%) | 0% | 145.2 | 931,901 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 144.04 per share. | 27 Feb 2026 | 3,481 | 648,827 (0%) | 0% | 144.0 | 501,386 | Common Stock |
| Dietmar Berger | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2026 | 8,530 | 17,912 (0%) | 0% | 0 | Common Stock | |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2026 | 11,090 | 131,378 (0%) | 0% | 0 | Common Stock | |
| Wettan Keeley M Cain | EVP Gen Counsel, Legal & Comp | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2026 | 470 | 4,414 (0%) | 0% | 0 | Common Stock | |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 154.43 per share. | 17 Feb 2026 | 3,000 | 167,779 (0%) | 0% | 154.4 | 463,290 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2026 | 25,000 | 48,110 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Sale of securities on an exchange or to another person at price $ 155.62 per share. | 17 Feb 2026 | 200 | 120,288 (0%) | 0% | 155.6 | 31,124 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Sale of securities on an exchange or to another person at price $ 154.91 per share. | 17 Feb 2026 | 9,395 | 120,488 (0%) | 0% | 154.9 | 1,455,384 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Sale of securities on an exchange or to another person at price $ 154.18 per share. | 17 Feb 2026 | 18,405 | 129,883 (0%) | 0% | 154.2 | 2,837,720 | Common Stock |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.64 per share. | 17 Feb 2026 | 25,000 | 148,288 (0%) | 0% | 66.6 | 1,666,000 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2026 | 115,640 | 0 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 150.00 per share. | 05 Feb 2026 | 115,640 | 613,912 (0%) | 0% | 150 | 17,346,000 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.01 per share. | 05 Feb 2026 | 115,640 | 729,552 (0%) | 0% | 66.0 | 7,633,396 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 143.28 per share. | 03 Feb 2026 | 24,802 | 170,568 (0%) | 0% | 143.3 | 3,553,631 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2026 | 44,867 | 195,370 (0%) | 0% | 0 | Common Stock | |
| Daniel P. O'Day | Director, Chairman & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 143.28 per share. | 03 Feb 2026 | 74,461 | 613,912 (0%) | 0% | 143.3 | 10,668,772 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2026 | 131,675 | 688,373 (0%) | 0% | 0 | Common Stock | |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2026 | 44,867 | 148,088 (0%) | 0% | 0 | Common Stock | |
| Johanna Mercier | Chief Comm & Corp Aff Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 143.28 per share. | 03 Feb 2026 | 24,800 | 123,288 (0%) | 0% | 143.3 | 3,553,344 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 140.24 per share. | 28 Jan 2026 | 4,968 | 556,698 (0%) | 0% | 140.2 | 696,725 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 139.54 per share. | 28 Jan 2026 | 5,032 | 561,666 (0%) | 0% | 139.5 | 702,186 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.01 per share. | 23 Jan 2026 | 115,640 | 682,338 (0%) | 0% | 66.0 | 7,633,396 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jan 2026 | 115,640 | 115,640 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 135.00 per share. | 23 Jan 2026 | 115,640 | 566,698 (0%) | 0% | 135 | 15,611,400 | Common Stock |
| Jeffrey A. Bluestone | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.45 per share. | 20 Jan 2026 | 5,000 | 13,920 (0%) | 0% | 67.5 | 337,250 | Common Stock |
| Jeffrey A. Bluestone | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jan 2026 | 5,000 | 4,665 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Jeffrey A. Bluestone | Director | Sale of securities on an exchange or to another person at price $ 123.50 per share. | 20 Jan 2026 | 5,000 | 8,920 (0%) | 0% | 123.5 | 617,500 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 124.31 per share. | 15 Jan 2026 | 3,000 | 150,503 (0%) | 0% | 124.3 | 372,930 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 124.31 per share. | 15 Jan 2026 | 3,000 | 103,221 (0%) | 0% | 124.3 | 372,930 | Common Stock |
| Dietmar Berger | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2026 | 16,326 | 16,326 (0%) | 0% | - | Common Stock | |
| Dietmar Berger | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 121.60 per share. | 02 Jan 2026 | 6,944 | 9,382 (0%) | 0% | 121.6 | 844,390 | Common Stock |
| Dietmar Berger | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2026 | 16,326 | 41,179 | - | - | Restricted Stock Unit | |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 124.83 per share. | 29 Dec 2025 | 10,000 | 566,698 (0%) | 0% | 124.8 | 1,248,272 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 122.00 per share. | 15 Dec 2025 | 3,000 | 153,503 (0%) | 0% | 122 | 366,000 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 122.00 per share. | 15 Dec 2025 | 3,000 | 106,221 (0%) | 0% | 122 | 366,000 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2025 | 3,693 | 158,248 (0%) | 0% | - | Common Stock | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2025 | 3,693 | 27,526 | - | - | Restricted Stock Unit | |
| Andrew D. Dickinson | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 121.34 per share. | 10 Dec 2025 | 1,745 | 156,503 (0%) | 0% | 121.3 | 211,738 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2025 | 10,426 | 88,070 | - | - | Restricted Stock Unit | |
| Daniel P. O'Day | Director, Chairman & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 121.34 per share. | 10 Dec 2025 | 4,931 | 576,698 (0%) | 0% | 121.3 | 598,328 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2025 | 10,426 | 581,629 (0%) | 0% | - | Common Stock | |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2025 | 3,842 | 27,674 | - | - | Restricted Stock Unit | |
| Johanna Mercier | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 121.34 per share. | 10 Dec 2025 | 1,814 | 109,221 (0%) | 0% | 121.3 | 220,111 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2025 | 3,842 | 111,035 (0%) | 0% | - | Common Stock | |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 125.91 per share. | 28 Nov 2025 | 3,212 | 577,991 (0%) | 0% | 125.9 | 404,428 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 126.84 per share. | 28 Nov 2025 | 6,788 | 571,203 (0%) | 0% | 126.8 | 861,016 | Common Stock |
| Jeffrey A. Bluestone | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 64.92 per share. | 28 Nov 2025 | 5,000 | 13,920 (0%) | 0% | 64.9 | 324,600 | Common Stock |
| Jeffrey A. Bluestone | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Nov 2025 | 5,000 | 7,648 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Jeffrey A. Bluestone | Director | Sale of securities on an exchange or to another person at price $ 125.08 per share. | 28 Nov 2025 | 5,000 | 8,920 (0%) | 0% | 125.1 | 625,400 | Common Stock |
| Kelly Anne Kramer | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 81.00 per share. | 26 Nov 2025 | 2,806 | 4,145 (0%) | 0% | 81 | 227,286 | Common Stock |
| Kelly Anne Kramer | Director | Sale of securities on an exchange or to another person at price $ 127.10 per share. | 26 Nov 2025 | 2,805 | 1,339 (0%) | 0% | 127.1 | 356,516 | Common Stock |
| Kelly Anne Kramer | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Nov 2025 | 2,805 | 0 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Kelly Anne Kramer | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Nov 2025 | 2,806 | 2,805 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Kelly Anne Kramer | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 81.00 per share. | 26 Nov 2025 | 2,805 | 4,144 (0%) | 0% | 81 | 227,205 | Common Stock |
| Kelly Anne Kramer | Director | Sale of securities on an exchange or to another person at price $ 127.11 per share. | 26 Nov 2025 | 2,806 | 1,339 (0%) | 0% | 127.1 | 356,671 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 125.23 per share. | 17 Nov 2025 | 2,500 | 154,555 (0%) | 0% | 125.2 | 313,075 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Nov 2025 | 25,000 | 73,110 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 126.26 per share. | 17 Nov 2025 | 2,476 | 107,193 (0%) | 0% | 126.3 | 312,614 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 125.83 per share. | 17 Nov 2025 | 25,524 | 109,669 (0%) | 0% | 125.8 | 3,211,560 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.64 per share. | 17 Nov 2025 | 25,000 | 135,193 (0%) | 0% | 66.6 | 1,666,000 | Common Stock |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 12 Nov 2025 | 17,181 | 60,857 (0%) | 0% | 75.1 | 1,290,637 | Common Stock | |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 12 Nov 2025 | 35,965 | 12,655 | - | - | Non-qualified Stock Option (Right to Buy) | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 12 Nov 2025 | 17,181 | 37,799 | - | - | Non-qualified Stock Option (Right to Buy) | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 12 Nov 2025 | 500 | 43,676 (0%) | 0% | 122.9 | 61,452 | Common Stock | |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 12 Nov 2025 | 500 | 44,176 (0%) | 0% | 60.8 | 30,375 | Common Stock | |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 12 Nov 2025 | 35,965 | 43,676 (0%) | 0% | 122.3 | 4,398,591 | Common Stock | |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 12 Nov 2025 | 35,965 | 79,641 (0%) | 0% | 60.8 | 2,184,874 | Common Stock | |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 12 Nov 2025 | 17,181 | 43,676 (0%) | 0% | 124 | 2,130,444 | Common Stock | |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 12 Nov 2025 | 500 | 12,155 | - | - | Non-qualified Stock Option (Right to Buy) | ||
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 118.82 per share. | 28 Oct 2025 | 2,022 | 581,203 (0%) | 0% | 118.8 | 240,259 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 119.54 per share. | 28 Oct 2025 | 7,978 | 583,225 (0%) | 0% | 119.5 | 953,667 | Common Stock |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Oct 2025 | 241 | 43,676 (0%) | 0% | 120.9 | 29,147 | Common Stock | |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Oct 2025 | 515 | 43,917 (0%) | 0% | - | Common Stock | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Oct 2025 | 515 | 19,816 | - | - | Restricted Stock Unit | ||
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 118.08 per share. | 15 Oct 2025 | 2,500 | 157,055 (0%) | 0% | 118.1 | 295,200 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 118.08 per share. | 15 Oct 2025 | 3,000 | 110,193 (0%) | 0% | 118.1 | 354,240 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 112.42 per share. | 29 Sep 2025 | 1,961 | 591,203 (0%) | 0% | 112.4 | 220,454 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 111.47 per share. | 29 Sep 2025 | 8,039 | 593,164 (0%) | 0% | 111.5 | 896,110 | Common Stock |
| Erin Burkhart | SVP, Controllership | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2025 | 8,890 | 8,890 | - | - | Restricted Stock Unit | |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 113.57 per share. | 15 Sep 2025 | 2,500 | 159,555 (0%) | 0% | 113.6 | 283,925 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 113.57 per share. | 15 Sep 2025 | 3,000 | 113,193 (0%) | 0% | 113.6 | 340,710 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2025 | 3,696 | 31,219 | - | - | Restricted Stock Unit | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2025 | 3,696 | 163,806 (0%) | 0% | - | Common Stock | |
| Andrew D. Dickinson | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 115.25 per share. | 10 Sep 2025 | 1,751 | 162,055 (0%) | 0% | 115.3 | 201,803 | Common Stock |
| Diane E. Wilfong | Interim Corp Controller & CAO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 115.25 per share. | 10 Sep 2025 | 338 | 46,259 (0%) | 0% | 115.3 | 38,955 | Common Stock |
| Diane E. Wilfong | Interim Corp Controller & CAO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2025 | 921 | 7,864 | - | - | Restricted Stock Unit | |
| Diane E. Wilfong | Interim Corp Controller & CAO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2025 | 921 | 46,597 (0%) | 0% | - | Common Stock | |
| Daniel P. O'Day | Director, Chairman & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 115.25 per share. | 10 Sep 2025 | 4,949 | 601,203 (0%) | 0% | 115.2 | 570,372 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2025 | 10,427 | 606,152 (0%) | 0% | - | Common Stock | |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2025 | 10,427 | 98,496 | - | - | Restricted Stock Unit | |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2025 | 3,844 | 118,012 (0%) | 0% | - | Common Stock | |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2025 | 3,844 | 31,516 | - | - | Restricted Stock Unit | |
| Johanna Mercier | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 115.25 per share. | 10 Sep 2025 | 1,819 | 116,193 (0%) | 0% | 115.3 | 209,640 | Common Stock |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 10 Sep 2025 | 634 | 43,402 (0%) | 0% | 115.3 | 73,069 | Common Stock | |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 10 Sep 2025 | 1,315 | 44,036 (0%) | 0% | - | Common Stock | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 10 Sep 2025 | 1,315 | 20,331 | - | - | Restricted Stock Unit | ||
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 113.63 per share. | 28 Aug 2025 | 10,000 | 595,725 (0%) | 0% | 113.6 | 1,136,300 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 118.53 per share. | 15 Aug 2025 | 2,500 | 160,110 (0%) | 0% | 118.5 | 296,325 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Aug 2025 | 700 | 98,110 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Aug 2025 | 11,800 | 98,810 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Aug 2025 | 700 | 110,610 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Aug 2025 | 11,800 | 111,310 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 118.96 per share. | 15 Aug 2025 | 200 | 114,168 (0%) | 0% | 119.0 | 23,793 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 118.51 per share. | 15 Aug 2025 | 2,800 | 114,368 (0%) | 0% | 118.5 | 331,821 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 118.97 per share. | 15 Aug 2025 | 700 | 117,168 (0%) | 0% | 119.0 | 83,278 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.64 per share. | 15 Aug 2025 | 700 | 117,868 (0%) | 0% | 66.6 | 46,648 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 118.51 per share. | 15 Aug 2025 | 11,800 | 117,168 (0%) | 0% | 118.5 | 1,398,405 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.64 per share. | 15 Aug 2025 | 11,800 | 128,968 (0%) | 0% | 66.6 | 786,352 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 118.97 per share. | 15 Aug 2025 | 700 | 117,168 (0%) | 0% | 119.0 | 83,278 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.64 per share. | 15 Aug 2025 | 700 | 117,868 (0%) | 0% | 66.6 | 46,648 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 118.50 per share. | 15 Aug 2025 | 11,800 | 117,168 (0%) | 0% | 118.5 | 1,398,352 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.64 per share. | 15 Aug 2025 | 11,800 | 128,968 (0%) | 0% | 66.6 | 786,352 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 114.09 per share. | 28 Jul 2025 | 8,345 | 605,725 (0%) | 0% | 114.1 | 952,077 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 113.17 per share. | 28 Jul 2025 | 1,655 | 614,070 (0%) | 0% | 113.2 | 187,293 | Common Stock |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Jul 2025 | 3,823 | 42,721 (0%) | 0% | 116.2 | 444,233 | Common Stock | |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Jul 2025 | 8,229 | 21,646 | - | - | Restricted Stock Unit | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Jul 2025 | 514 | 29,875 | - | - | Restricted Stock Unit | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Jul 2025 | 8,229 | 46,544 (0%) | 0% | - | Common Stock | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Jul 2025 | 514 | 38,315 (0%) | 0% | - | Common Stock | ||
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 111.03 per share. | 15 Jul 2025 | 2,500 | 162,610 (0%) | 0% | 111.0 | 277,575 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 111.03 per share. | 15 Jul 2025 | 3,000 | 117,168 (0%) | 0% | 111.0 | 333,090 | Common Stock |
| Jeffrey A. Bluestone | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.45 per share. | 14 Jul 2025 | 5,000 | 13,920 (0%) | 0% | 67.5 | 337,250 | Common Stock |
| Jeffrey A. Bluestone | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jul 2025 | 5,000 | 9,665 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Jeffrey A. Bluestone | Director | Sale of securities on an exchange or to another person at price $ 109.74 per share. | 14 Jul 2025 | 5,000 | 8,920 (0%) | 0% | 109.7 | 548,700 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 111.15 per share. | 30 Jun 2025 | 600 | 615,725 (0%) | 0% | 111.1 | 66,688 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 110.40 per share. | 30 Jun 2025 | 9,400 | 616,325 (0%) | 0% | 110.4 | 1,037,796 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 110.17 per share. | 16 Jun 2025 | 2,500 | 165,110 (0%) | 0% | 110.2 | 275,425 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 110.17 per share. | 16 Jun 2025 | 3,000 | 120,168 (0%) | 0% | 110.2 | 330,510 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 3,694 | 169,368 (0%) | 0% | - | Common Stock | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 3,694 | 34,915 | - | - | Restricted Stock Unit | |
| Andrew D. Dickinson | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 110.09 per share. | 10 Jun 2025 | 1,758 | 167,610 (0%) | 0% | 110.1 | 193,538 | Common Stock |
| Diane E. Wilfong | Interim Corp Controller & CAO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 920 | 8,785 | - | - | Restricted Stock Unit | |
| Diane E. Wilfong | Interim Corp Controller & CAO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 110.09 per share. | 10 Jun 2025 | 340 | 45,676 (0%) | 0% | 110.1 | 37,431 | Common Stock |
| Diane E. Wilfong | Interim Corp Controller & CAO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 920 | 46,016 (0%) | 0% | - | Common Stock | |
| Daniel P. O'Day | Director, Chairman & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 110.09 per share. | 10 Jun 2025 | 4,968 | 625,725 (0%) | 0% | 110.1 | 546,927 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 10,425 | 108,923 | - | - | Restricted Stock Unit | |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 10,425 | 630,693 (0%) | 0% | - | Common Stock | |
| Johanna Mercier | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 110.09 per share. | 10 Jun 2025 | 1,827 | 123,168 (0%) | 0% | 110.1 | 201,134 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 3,843 | 124,995 (0%) | 0% | - | Common Stock | |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 3,843 | 35,360 | - | - | Restricted Stock Unit | |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 10 Jun 2025 | 1,313 | 30,389 | - | - | Restricted Stock Unit | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 10 Jun 2025 | 1,313 | 38,231 (0%) | 0% | - | Common Stock | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 10 Jun 2025 | 430 | 37,801 (0%) | 0% | 110.1 | 47,339 | Common Stock | |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 110.96 per share. | 30 May 2025 | 3,584 | 620,268 (0%) | 0% | 111.0 | 397,696 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 110.11 per share. | 30 May 2025 | 6,416 | 623,852 (0%) | 0% | 110.1 | 706,497 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.64 per share. | 22 May 2025 | 12,500 | 136,652 (0%) | 0% | 66.6 | 833,000 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 May 2025 | 12,500 | 123,110 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 May 2025 | 12,500 | 135,610 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 107.52 per share. | 22 May 2025 | 3,000 | 121,152 (0%) | 0% | 107.5 | 322,564 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 107.52 per share. | 22 May 2025 | 12,500 | 124,152 (0%) | 0% | 107.5 | 1,344,039 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.64 per share. | 22 May 2025 | 12,500 | 136,652 (0%) | 0% | 66.6 | 833,000 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 107.52 per share. | 22 May 2025 | 12,500 | 124,152 (0%) | 0% | 107.5 | 1,343,961 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 99.82 per share. | 15 May 2025 | 2,500 | 165,674 (0%) | 0% | 99.8 | 249,550 | Common Stock |
| Jeffrey A. Bluestone | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 May 2025 | 6,809 | 6,809 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Jeffrey A. Bluestone | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 May 2025 | 1,516 | 5,713 | - | - | Restricted Stock Unit | |
| Anthony Welters | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 May 2025 | 6,809 | 6,809 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Anthony Welters | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 May 2025 | 1,516 | 11,748 (0%) | 0% | 0 | Common Stock | |
| Jacqueline K. Barton | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 May 2025 | 1,516 | 26,056 (0%) | 0% | 0 | Common Stock | |
| Jacqueline K. Barton | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 May 2025 | 6,809 | 6,809 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Javier J. Rodriguez | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 May 2025 | 1,516 | 12,218 (0%) | 0% | 0 | Common Stock | |
| Javier J. Rodriguez | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 May 2025 | 6,809 | 6,809 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Ted W. Love | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 May 2025 | 1,516 | 4,338 (0%) | 0% | 0 | Common Stock | |
| Ted W. Love | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 May 2025 | 6,809 | 6,809 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Harish Manwani | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 May 2025 | 6,809 | 6,809 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Harish Manwani | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 May 2025 | 1,516 | 14,389 (0%) | 0% | 0 | Common Stock | |
| Harish Manwani | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 98.90 per share. | 07 May 2025 | 296 | 14,093 (0%) | 0% | 98.9 | 29,274 | Common Stock |
| Kelly Anne Kramer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 May 2025 | 6,809 | 6,809 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Kelly Anne Kramer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 May 2025 | 1,516 | 19,110 | - | - | Restricted Stock Unit | |
| Sandra J. Horning | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 May 2025 | 1,516 | 5,147 (0%) | 0% | 0 | Common Stock | |
| Sandra J. Horning | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 May 2025 | 6,809 | 6,809 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Apr 2025 | 514 | 37,076 (0%) | 0% | - | Common Stock | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Apr 2025 | 514 | 31,702 | - | - | Restricted Stock Unit | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Apr 2025 | 158 | 36,918 (0%) | 0% | 103.2 | 16,301 | Common Stock | |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 106.40 per share. | 15 Apr 2025 | 2,500 | 168,174 (0%) | 0% | 106.4 | 266,000 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 110.53 per share. | 17 Mar 2025 | 2,500 | 170,674 (0%) | 0% | 110.5 | 276,325 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 11,090 | 38,609 | - | - | Restricted Stock Unit | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.91 per share. | 10 Mar 2025 | 4,916 | 173,977 (0%) | 0% | 63.9 | 314,182 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.91 per share. | 10 Mar 2025 | 13,013 | 186,990 (0%) | 0% | 63.9 | 831,661 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 117.30 per share. | 10 Mar 2025 | 4,916 | 182,074 (0%) | 0% | 117.3 | 576,641 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 118.50 per share. | 10 Mar 2025 | 13,013 | 169,061 (0%) | 0% | 118.5 | 1,542,055 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 7,968 | 177,029 (0%) | 0% | - | Common Stock | |
| Andrew D. Dickinson | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 117.21 per share. | 10 Mar 2025 | 3,855 | 173,174 (0%) | 0% | 117.2 | 451,845 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 4,916 | 13,013 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 13,013 | 0 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 7,968 | 27,519 | - | - | Restricted Stock Unit | |
| Andrew D. Dickinson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 49,020 | 49,020 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Daniel P. O'Day | Director, Chairman & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 38,395 | 119,348 | - | - | Restricted Stock Unit | |
| Daniel P. O'Day | Director, Chairman & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 169,690 | 169,690 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 24,024 | 80,953 | - | - | Restricted Stock Unit | |
| Daniel P. O'Day | Director, Chairman & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 117.21 per share. | 10 Mar 2025 | 11,632 | 630,268 (0%) | 0% | 117.2 | 1,363,387 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 24,024 | 641,900 (0%) | 0% | - | Common Stock | |
| Dietmar Berger | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 8,530 | 57,505 | - | - | Restricted Stock Unit | |
| Dietmar Berger | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 37,710 | 37,710 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Johanna Mercier | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 117.21 per share. | 10 Mar 2025 | 3,907 | 124,152 (0%) | 0% | 117.2 | 457,939 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 8,080 | 28,113 | - | - | Restricted Stock Unit | |
| Johanna Mercier | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 49,020 | 49,020 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Johanna Mercier | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2025 | 11,090 | 39,203 | - | - | Restricted Stock Unit | |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 8,080 | 128,059 (0%) | 0% | - | Common Stock | |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 10 Mar 2025 | 3,343 | 37,692 (0%) | 0% | - | Common Stock | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 10 Mar 2025 | 3,343 | 24,356 | - | - | Restricted Stock Unit | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 10 Mar 2025 | 33,940 | 33,940 | - | - | Non-qualified Stock Option (Right to Buy) | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 10 Mar 2025 | 7,680 | 32,216 | - | - | Restricted Stock Unit | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 10 Mar 2025 | 1,130 | 36,562 (0%) | 0% | 117.2 | 132,447 | Common Stock | |
| Sandra Patterson | SVP, Controllership | Payment of exercise price or tax liability using portion of securities received from the company at price $ 117.21 per share. | 10 Mar 2025 | 624 | 39,453 (0%) | 0% | 117.2 | 73,139 | Common Stock |
| Sandra Patterson | SVP, Controllership | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 1,952 | 9,875 | - | - | Restricted Stock Unit | |
| Sandra Patterson | SVP, Controllership | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 1,952 | 40,077 (0%) | 0% | - | Common Stock | |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 104.09 per share. | 18 Feb 2025 | 2,500 | 169,061 (0%) | 0% | 104.1 | 260,225 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 18,210 | 0 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 15,600 | 0 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 77,691 | 17,929 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 102.22 per share. | 12 Feb 2025 | 137,676 | 171,223 (0%) | 0% | 102.2 | 14,073,241 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 83.49 per share. | 12 Feb 2025 | 18,210 | 308,899 (0%) | 0% | 83.5 | 1,520,353 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 80.72 per share. | 12 Feb 2025 | 15,600 | 290,689 (0%) | 0% | 80.7 | 1,259,232 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 57.92 per share. | 12 Feb 2025 | 26,175 | 275,089 (0%) | 0% | 57.9 | 1,516,056 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.91 per share. | 12 Feb 2025 | 77,691 | 248,914 (0%) | 0% | 63.9 | 4,965,232 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2025 | 26,175 | 78,515 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Andrew D. Dickinson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 19,793 | 149,666 (0%) | 0% | 0 | Common Stock | |
| Andrew D. Dickinson | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 97.99 per share. | 04 Feb 2025 | 43,138 | 171,223 (0%) | 0% | 98.0 | 4,227,093 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 64,695 | 214,361 (0%) | 0% | 0 | Common Stock | |
| Daniel P. O'Day | Director, Chairman & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 164,473 | 726,032 (0%) | 0% | 0 | Common Stock | |
| Daniel P. O'Day | Director, Chairman & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 60,031 | 561,559 (0%) | 0% | 0 | Common Stock | |
| Daniel P. O'Day | Director, Chairman & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 97.99 per share. | 04 Feb 2025 | 108,156 | 617,876 (0%) | 0% | 98.0 | 10,598,206 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 70,712 | 165,645 (0%) | 0% | 0 | Common Stock | |
| Johanna Mercier | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 97.99 per share. | 04 Feb 2025 | 45,666 | 119,979 (0%) | 0% | 98.0 | 4,474,811 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 19,793 | 94,933 (0%) | 0% | 0 | Common Stock | |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 04 Feb 2025 | 12,371 | 34,011 (0%) | 0% | 0 | Common Stock | ||
| Sandra Patterson | SVP, Controllership | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2025 | 709 | 37,787 (0%) | 0% | 0 | Common Stock | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 44,160 | 0 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 65.38 per share. | 31 Jan 2025 | 44,160 | 273,053 (0%) | 0% | 65.4 | 2,887,181 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 97.22 per share. | 31 Jan 2025 | 142,180 | 129,873 (0%) | 0% | 97.2 | 13,822,740 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 26,170 | 104,690 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 71,850 | 0 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 57.92 per share. | 31 Jan 2025 | 26,170 | 156,043 (0%) | 0% | 57.9 | 1,515,766 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 72.34 per share. | 31 Jan 2025 | 71,850 | 227,893 (0%) | 0% | 72.3 | 5,197,629 | Common Stock |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Jan 2025 | 515 | 21,827 (0%) | 0% | - | Common Stock | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Jan 2025 | 187 | 21,640 (0%) | 0% | 93.1 | 17,404 | Common Stock | |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Jan 2025 | 515 | 27,879 | - | - | Restricted Stock Unit | ||
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 91.35 per share. | 15 Jan 2025 | 2,500 | 129,873 (0%) | 0% | 91.4 | 228,375 | Common Stock |
| Dietmar Berger | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 48,975 | 48,975 | - | - | Restricted Stock Unit | |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 91.96 per share. | 16 Dec 2024 | 8,500 | 132,373 (0%) | 0% | 92.0 | 781,660 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2024 | 3,640 | 142,559 (0%) | 0% | - | Common Stock | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2024 | 3,640 | 35,487 | - | - | Restricted Stock Unit | |
| Andrew D. Dickinson | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 92.34 per share. | 10 Dec 2024 | 1,686 | 140,873 (0%) | 0% | 92.3 | 155,685 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2024 | 10,295 | 506,290 (0%) | 0% | - | Common Stock | |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2024 | 10,295 | 104,977 | - | - | Restricted Stock Unit | |
| Daniel P. O'Day | Director, Chairman & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 92.34 per share. | 10 Dec 2024 | 4,762 | 501,528 (0%) | 0% | 92.3 | 439,723 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2024 | 3,752 | 36,193 | - | - | Restricted Stock Unit | |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2024 | 3,752 | 76,879 (0%) | 0% | - | Common Stock | |
| Johanna Mercier | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 92.34 per share. | 10 Dec 2024 | 1,739 | 75,140 (0%) | 0% | 92.3 | 160,579 | Common Stock |
| Merdad V. Parsey | Chief Medical Officer | 10 Dec 2024 | 3,820 | 36,753 | - | - | Restricted Stock Unit | ||
| Merdad V. Parsey | Chief Medical Officer | 10 Dec 2024 | 1,771 | 82,850 (0%) | 0% | 92.3 | 163,534 | Common Stock | |
| Merdad V. Parsey | Chief Medical Officer | 10 Dec 2024 | 3,820 | 84,621 (0%) | 0% | - | Common Stock | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 10 Dec 2024 | 306 | 21,312 (0%) | 0% | 92.3 | 28,256 | Common Stock | |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 10 Dec 2024 | 639 | 28,394 | - | - | Restricted Stock Unit | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 10 Dec 2024 | 639 | 21,618 (0%) | 0% | - | Common Stock | ||
| Sandra Patterson | SVP, Controllership | 10 Dec 2024 | 901 | 12,282 | - | - | Restricted Stock Unit | ||
| Sandra Patterson | SVP, Controllership | 10 Dec 2024 | 901 | 37,486 (0%) | 0% | - | Common Stock | ||
| Sandra Patterson | SVP, Controllership | 10 Dec 2024 | 408 | 37,078 (0%) | 0% | 92.3 | 37,675 | Common Stock | |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 92.76 per share. | 29 Nov 2024 | 127,930 | 138,919 (0%) | 0% | 92.8 | 11,867,119 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Nov 2024 | 65,960 | 0 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Nov 2024 | 43,340 | 0 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Nov 2024 | 60,885 | 0 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Nov 2024 | 33,660 | 0 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Nov 2024 | 18,630 | 0 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Nov 2024 | 26,170 | 130,860 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Andrew D. Dickinson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 92.77 per share. | 29 Nov 2024 | 120,715 | 266,849 (0%) | 0% | 92.8 | 11,198,151 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 72.70 per share. | 29 Nov 2024 | 65,960 | 387,564 (0%) | 0% | 72.7 | 4,795,292 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 72.70 per share. | 29 Nov 2024 | 43,340 | 321,604 (0%) | 0% | 72.7 | 3,150,818 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 71.91 per share. | 29 Nov 2024 | 60,885 | 278,264 (0%) | 0% | 71.9 | 4,378,240 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 68.75 per share. | 29 Nov 2024 | 33,660 | 217,379 (0%) | 0% | 68.8 | 2,314,125 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 57.92 per share. | 29 Nov 2024 | 26,170 | 183,719 (0%) | 0% | 57.9 | 1,515,766 | Common Stock |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 73.77 per share. | 29 Nov 2024 | 18,630 | 157,549 (0%) | 0% | 73.8 | 1,374,335 | Common Stock |
| Merdad Parsey V. | Chief Medical Officer | 27 Nov 2024 | 3,199 | 91,200 (0%) | 0% | 91.8 | 293,679 | Common Stock | |
| Parsey Merdad V. | Chief Medical Officer | 27 Nov 2024 | 88,119 | 99,599 (0%) | 0% | 92 | 8,106,948 | Common Stock | |
| V. Merdad Parsey | Chief Medical Officer | 27 Nov 2024 | 57,294 | 187,718 (0%) | 0% | 91.8 | 5,259,297 | Common Stock | |
| Parsey V. Merdad | Chief Medical Officer | 27 Nov 2024 | 88,119 | 196 | - | - | Non-qualified Stock Option (Right to Buy) | ||
| V. Merdad Parsey | Chief Medical Officer | 27 Nov 2024 | 57,294 | 64,376 | - | - | Non-qualified Stock Option (Right to Buy) | ||
| V. Merdad Parsey | Chief Medical Officer | 27 Nov 2024 | 88,119 | 245,012 (0%) | 0% | 65.4 | 5,761,220 | Common Stock | |
| Merdad Parsey V. | Chief Medical Officer | 27 Nov 2024 | 57,294 | 156,893 (0%) | 0% | 57.9 | 3,318,468 | Common Stock | |
| Parsey V. Merdad | Chief Medical Officer | 27 Nov 2024 | 5,200 | 94,399 (0%) | 0% | 91.8 | 477,381 | Common Stock | |
| Parsey V. Merdad | Chief Medical Officer | 27 Nov 2024 | 10,399 | 80,801 (0%) | 0% | 92 | 956,708 | Common Stock | |
| Bluestone A. Jeffrey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Nov 2024 | 4,121 | 11,730 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Jeffrey A. Bluestone | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Nov 2024 | 5,879 | 0 | - | - | Non-qualified Stock Option (Right to Buy) | |
| A. Bluestone Jeffrey | Director | Sale of securities on an exchange or to another person at price $ 91.39 per share. | 26 Nov 2024 | 6,788 | 8,920 (0%) | 0% | 91.4 | 620,356 | Common Stock |
| A. Bluestone Jeffrey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 61.35 per share. | 26 Nov 2024 | 4,121 | 15,708 (0%) | 0% | 61.3 | 252,823 | Common Stock |
| Jeffrey Bluestone A. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 61.17 per share. | 26 Nov 2024 | 5,879 | 11,587 (0%) | 0% | 61.2 | 359,618 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 91.28 per share. | 06 Nov 2024 | 5,000 | 73,127 (0%) | 0% | 91.3 | 456,400 | Common Stock |
| Merdad V. Parsey | Chief Medical Officer | 06 Nov 2024 | 25,000 | 125,189 (0%) | 0% | 57.9 | 1,448,000 | Common Stock | |
| Merdad V. Parsey | Chief Medical Officer | 06 Nov 2024 | 25,000 | 121,670 | - | - | Non-qualified Stock Option (Right to Buy) | ||
| Merdad V. Parsey | Chief Medical Officer | 06 Nov 2024 | 5,000 | 99,599 (0%) | 0% | 91.5 | 457,500 | Common Stock | |
| Merdad V. Parsey | Chief Medical Officer | 06 Nov 2024 | 20,590 | 104,599 (0%) | 0% | 91.5 | 1,883,985 | Common Stock | |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Oct 2024 | 514 | 29,033 | - | - | Restricted Stock Unit | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Oct 2024 | 242 | 20,979 (0%) | 0% | 89 | 21,538 | Common Stock | |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Oct 2024 | 514 | 21,221 (0%) | 0% | - | Common Stock | ||
| Merdad V. Parsey | Chief Medical Officer | 01 Oct 2024 | 2,000 | 100,189 (0%) | 0% | 83.8 | 167,660 | Common Stock | |
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 84.23 per share. | 12 Sep 2024 | 15,925 | 91,559 (0%) | 0% | 84.2 | 1,341,363 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 83.25 per share. | 12 Sep 2024 | 13,432 | 78,127 (0%) | 0% | 83.3 | 1,118,214 | Common Stock |
| Merdad V. Parsey | Chief Medical Officer | 12 Sep 2024 | 25,000 | 146,670 | - | - | Non-qualified Stock Option (Right to Buy) | ||
| Merdad V. Parsey | Chief Medical Officer | 12 Sep 2024 | 21,246 | 102,189 (0%) | 0% | 84.5 | 1,795,287 | Common Stock | |
| Merdad V. Parsey | Chief Medical Officer | 12 Sep 2024 | 25,000 | 123,435 (0%) | 0% | 57.9 | 1,448,000 | Common Stock | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2024 | 3,641 | 140,601 (0%) | 0% | - | Common Stock | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2024 | 3,641 | 39,127 | - | - | Restricted Stock Unit | |
| Andrew D. Dickinson | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 81.44 per share. | 10 Sep 2024 | 1,682 | 138,919 (0%) | 0% | 81.4 | 136,982 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2024 | 10,295 | 500,744 (0%) | 0% | - | Common Stock | |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2024 | 10,295 | 115,272 | - | - | Restricted Stock Unit | |
| Daniel P. O'Day | Director, Chairman & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 81.44 per share. | 10 Sep 2024 | 4,749 | 495,995 (0%) | 0% | 81.4 | 386,759 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 81.44 per share. | 10 Sep 2024 | 1,734 | 107,484 (0%) | 0% | 81.4 | 141,217 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2024 | 3,752 | 39,945 | - | - | Restricted Stock Unit | |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2024 | 3,752 | 109,218 (0%) | 0% | - | Common Stock | |
| Merdad V. Parsey | Chief Medical Officer | 10 Sep 2024 | 1,766 | 98,435 (0%) | 0% | 81.4 | 143,823 | Common Stock | |
| Merdad V. Parsey | Chief Medical Officer | 10 Sep 2024 | 3,821 | 40,573 | - | - | Restricted Stock Unit | ||
| Merdad V. Parsey | Chief Medical Officer | 10 Sep 2024 | 3,821 | 100,201 (0%) | 0% | - | Common Stock | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 10 Sep 2024 | 307 | 20,707 (0%) | 0% | 81.4 | 25,002 | Common Stock | |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 10 Sep 2024 | 639 | 21,014 (0%) | 0% | - | Common Stock | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 10 Sep 2024 | 639 | 29,547 | - | - | Restricted Stock Unit | ||
| Sandra Patterson | SVP, Controllership | 10 Sep 2024 | 292 | 36,585 (0%) | 0% | 81.4 | 23,780 | Common Stock | |
| Sandra Patterson | SVP, Controllership | 10 Sep 2024 | 901 | 13,183 | - | - | Restricted Stock Unit | ||
| Sandra Patterson | SVP, Controllership | 10 Sep 2024 | 901 | 36,877 (0%) | 0% | - | Common Stock | ||
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 78.03 per share. | 28 Aug 2024 | 9,513 | 105,466 (0%) | 0% | 78.0 | 742,299 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 73.98 per share. | 13 Aug 2024 | 5,490 | 114,979 (0%) | 0% | 74.0 | 406,150 | Common Stock |
| Sandra Patterson | SVP, Controllership | 10 Aug 2024 | 3,678 | 14,084 | - | - | Restricted Stock Unit | ||
| Sandra Patterson | SVP, Controllership | 10 Aug 2024 | 3,678 | 36,956 (0%) | 0% | - | Common Stock | ||
| Sandra Patterson | SVP, Controllership | 10 Aug 2024 | 980 | 35,976 (0%) | 0% | 73.7 | 72,187 | Common Stock | |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Jul 2024 | 2,917 | 11,631 (0%) | 0% | 76.5 | 223,180 | Common Stock | |
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Jul 2024 | 514 | 12,145 (0%) | 0% | - | Common Stock | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Jul 2024 | 8,230 | 20,375 (0%) | 0% | - | Common Stock | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Jul 2024 | 514 | 38,416 | - | - | Restricted Stock Unit | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 25 Jul 2024 | 8,230 | 30,186 | - | - | Restricted Stock Unit | ||
| Merdad V. Parsey | Chief Medical Officer | 01 Jul 2024 | 2,000 | 96,380 (0%) | 0% | 68.6 | 137,260 | Common Stock | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2024 | 3,639 | 138,622 (0%) | 0% | - | Common Stock | |
| Andrew D. Dickinson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2024 | 3,639 | 42,768 | - | - | Restricted Stock Unit | |
| Andrew D. Dickinson | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 65.25 per share. | 10 Jun 2024 | 1,662 | 136,960 (0%) | 0% | 65.3 | 108,446 | Common Stock |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2024 | 10,295 | 125,567 | - | - | Restricted Stock Unit | |
| Daniel P. O'Day | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2024 | 10,295 | 495,142 (0%) | 0% | - | Common Stock | |
| Daniel P. O'Day | Director, Chairman & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 65.25 per share. | 10 Jun 2024 | 4,693 | 490,449 (0%) | 0% | 65.2 | 306,218 | Common Stock |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2024 | 3,751 | 122,183 (0%) | 0% | - | Common Stock | |
| Johanna Mercier | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2024 | 3,751 | 43,697 | - | - | Restricted Stock Unit | |
| Johanna Mercier | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 65.25 per share. | 10 Jun 2024 | 1,714 | 120,469 (0%) | 0% | 65.3 | 111,839 | Common Stock |
| Merdad V. Parsey | Chief Medical Officer | 10 Jun 2024 | 3,820 | 44,394 | - | - | Restricted Stock Unit | ||
| Merdad V. Parsey | Chief Medical Officer | 10 Jun 2024 | 1,744 | 98,380 (0%) | 0% | 65.3 | 113,796 | Common Stock | |
| Merdad V. Parsey | Chief Medical Officer | 10 Jun 2024 | 3,820 | 100,124 (0%) | 0% | - | Common Stock | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 10 Jun 2024 | 638 | 14,752 (0%) | 0% | - | Common Stock | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 10 Jun 2024 | 638 | 38,930 | - | - | Restricted Stock Unit | ||
| Deborah H. Telman | EVP, Corporate Affairs & GC | 10 Jun 2024 | 204 | 14,548 (0%) | 0% | 65.3 | 13,311 | Common Stock | |
| Sandra Patterson | SVP, Controllership | 10 Jun 2024 | 255 | 33,278 (0%) | 0% | 65.3 | 16,639 | Common Stock | |
| Sandra Patterson | SVP, Controllership | 10 Jun 2024 | 901 | 17,762 | - | - | Restricted Stock Unit | ||
| Sandra Patterson | SVP, Controllership | 10 Jun 2024 | 901 | 33,533 (0%) | 0% | - | Common Stock | ||
| Kelly Anne Kramer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2024 | 2,310 | 17,594 | - | - | Restricted Stock Unit | |
| Kelly Anne Kramer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2024 | 12,648 | 12,648 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Sandra J. Horning | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2024 | 12,648 | 12,648 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Sandra J. Horning | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2024 | 2,310 | 7,801 | - | - | Restricted Stock Unit | |
| Anthony Welters | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2024 | 2,310 | 10,232 (0%) | 0% | 0 | Common Stock | |
| Anthony Welters | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2024 | 12,648 | 12,648 | - | - | Non-qualified Stock Option (Right to Buy) |