XNAS 04 Sep, 2026 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Melvin Sharoky | Director | Sale of securities on an exchange or to another person at price $ 127.53 per share. | 17 Aug 2026 | 5,000 | 0 (0%) | 0% | 127.5 | 637,650 | Common Stock |
| Roger Adsett | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.67 per share. | 10 Aug 2026 | 82,280 | 181,024 (0%) | 0% | 13.7 | 1,124,768 | Common Stock |
| Roger Adsett | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.46 per share. | 10 Aug 2026 | 80,970 | 338,594 (0%) | 0% | 30.5 | 2,466,346 | Common Stock |
| Roger Adsett | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.16 per share. | 10 Aug 2026 | 76,600 | 257,624 (0%) | 0% | 17.2 | 1,314,456 | Common Stock |
| Roger Adsett | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Aug 2026 | 82,280 | 0 | - | - | Stock Option (right to buy) | |
| Roger Adsett | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Aug 2026 | 76,600 | 0 | - | - | Stock Option (right to buy) | |
| Roger Adsett | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Aug 2026 | 80,970 | 0 | - | - | Stock Option (right to buy) | |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 133.27 per share. | 10 Aug 2026 | 239,850 | 98,744 (0%) | 0% | 133.3 | 31,964,810 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2026 | 8,895 | 35,580 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2026 | 18,278 | 36,555 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 129.40 per share. | 06 Aug 2026 | 18,278 | 60,486 (0%) | 0% | 129.4 | 2,365,173 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 127.00 per share. | 06 Aug 2026 | 8,895 | 78,764 (0%) | 0% | 127 | 1,129,665 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 25.83 per share. | 06 Aug 2026 | 8,895 | 87,659 (0%) | 0% | 25.8 | 229,758 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.95 per share. | 06 Aug 2026 | 18,278 | 78,764 (0%) | 0% | 18.9 | 346,368 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jul 2026 | 4,440 | 0 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jul 2026 | 6,260 | 0 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 106.43 per share. | 23 Jul 2026 | 5,872 | 259,058 (0%) | 0% | 106.4 | 624,957 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 105.62 per share. | 23 Jul 2026 | 4,828 | 264,930 (0%) | 0% | 105.6 | 509,933 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.16 per share. | 23 Jul 2026 | 4,440 | 269,758 (0%) | 0% | 17.2 | 76,190 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.46 per share. | 23 Jul 2026 | 6,260 | 265,318 (0%) | 0% | 30.5 | 190,680 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.46 per share. | 09 Jul 2026 | 6,259 | 265,317 (0%) | 0% | 30.5 | 190,649 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jul 2026 | 4,440 | 4,440 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jul 2026 | 6,259 | 6,260 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 118.52 per share. | 09 Jul 2026 | 3,359 | 259,058 (0%) | 0% | 118.5 | 398,109 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 117.62 per share. | 09 Jul 2026 | 2,335 | 262,417 (0%) | 0% | 117.6 | 274,643 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 116.55 per share. | 09 Jul 2026 | 5,005 | 264,752 (0%) | 0% | 116.6 | 583,333 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.16 per share. | 09 Jul 2026 | 4,440 | 269,757 (0%) | 0% | 17.2 | 76,190 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 109.02 per share. | 06 Jul 2026 | 4,854 | 67,934 (0%) | 0% | 109.0 | 529,183 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.74 per share. | 06 Jul 2026 | 4,357 | 72,788 (0%) | 0% | 19.7 | 86,007 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.13 per share. | 06 Jul 2026 | 7,945 | 68,431 (0%) | 0% | 29.1 | 231,438 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jul 2026 | 4,357 | 4,358 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jul 2026 | 7,945 | 23,835 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 110.60 per share. | 06 Jul 2026 | 7,448 | 60,486 (0%) | 0% | 110.6 | 823,749 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.46 per share. | 25 Jun 2026 | 12,518 | 271,435 (0%) | 0% | 30.5 | 381,298 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2026 | 8,880 | 8,880 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2026 | 12,518 | 12,519 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 106.27 per share. | 25 Jun 2026 | 1,292 | 258,917 (0%) | 0% | 106.3 | 137,301 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 105.27 per share. | 25 Jun 2026 | 2,456 | 260,209 (0%) | 0% | 105.3 | 258,543 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 104.28 per share. | 25 Jun 2026 | 3,723 | 262,665 (0%) | 0% | 104.3 | 388,234 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 103.10 per share. | 25 Jun 2026 | 1,836 | 266,388 (0%) | 0% | 103.1 | 189,292 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 102.34 per share. | 25 Jun 2026 | 12,091 | 268,224 (0%) | 0% | 102.3 | 1,237,393 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.16 per share. | 25 Jun 2026 | 8,880 | 280,315 (0%) | 0% | 17.2 | 152,381 | Common Stock |
| Samuele Butera | SVP, GM, Global Respiratory | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jun 2026 | 12,570 | 12,570 | - | - | Stock Option (right to buy) | |
| Samuele Butera | SVP, GM, Global Respiratory | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jun 2026 | 7,342 | 7,342 (0%) | 0% | - | Common Stock | |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 95.82 per share. | 22 Jun 2026 | 1,806 | 37,648 (0%) | 0% | 95.8 | 173,051 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 94.03 per share. | 08 Jun 2026 | 6,515 | 258,917 (0%) | 0% | 94.0 | 612,605 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 102.27 per share. | 03 Jun 2026 | 7,605 | 265,432 (0%) | 0% | 102.3 | 777,763 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 102.27 per share. | 03 Jun 2026 | 2,404 | 69,082 (0%) | 0% | 102.3 | 245,857 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 102.27 per share. | 03 Jun 2026 | 2,370 | 98,603 (0%) | 0% | 102.3 | 242,380 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 102.27 per share. | 03 Jun 2026 | 2,566 | 62,344 (0%) | 0% | 102.3 | 262,425 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 103.78 per share. | 03 Jun 2026 | 1,858 | 60,486 (0%) | 0% | 103.8 | 192,823 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 102.27 per share. | 03 Jun 2026 | 2,159 | 39,454 (0%) | 0% | 102.3 | 220,801 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 108.47 per share. | 22 May 2026 | 6,149 | 41,613 (0%) | 0% | 108.5 | 666,982 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 106.97 per share. | 18 May 2026 | 7,975 | 273,037 (0%) | 0% | 107.0 | 853,086 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 106.39 per share. | 18 May 2026 | 11,836 | 281,012 (0%) | 0% | 106.4 | 1,259,232 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 105.32 per share. | 18 May 2026 | 5,753 | 292,848 (0%) | 0% | 105.3 | 605,906 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 May 2026 | 6,259 | 25,037 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.16 per share. | 18 May 2026 | 4,440 | 298,601 (0%) | 0% | 17.2 | 76,190 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.46 per share. | 18 May 2026 | 6,259 | 294,161 (0%) | 0% | 30.5 | 190,649 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 May 2026 | 4,440 | 17,760 | - | - | Stock Option (right to buy) | |
| Carol A. Schafer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2026 | 3,305 | 66,622 (0%) | 0% | - | Common Stock | |
| Melvin Sharoky | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2026 | 3,305 | 246,081 (0%) | 0% | - | Common Stock | |
| David R. Brennan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2026 | 3,305 | 64,238 (0%) | 0% | - | Common Stock | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 116.18 per share. | 13 May 2026 | 13,283 | 287,902 (0%) | 0% | 116.2 | 1,543,219 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 116.18 per share. | 13 May 2026 | 8,272 | 71,486 (0%) | 0% | 116.2 | 961,041 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 116.18 per share. | 13 May 2026 | 5,837 | 100,973 (0%) | 0% | 116.2 | 678,143 | Common Stock |
| Clarissa Desjardins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2026 | 3,305 | 70,312 (0%) | 0% | - | Common Stock | |
| Leo Lee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2026 | 3,305 | 57,971 (0%) | 0% | - | Common Stock | |
| Elizabeth McKee Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2026 | 3,305 | 62,034 (0%) | 0% | - | Common Stock | |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 112.76 per share. | 13 May 2026 | 4,470 | 78,773 (0%) | 0% | 112.8 | 504,037 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 116.18 per share. | 13 May 2026 | 3,384 | 75,389 (0%) | 0% | 116.2 | 393,153 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 117.54 per share. | 13 May 2026 | 10,479 | 64,910 (0%) | 0% | 117.5 | 1,231,702 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 116.18 per share. | 13 May 2026 | 4,109 | 47,762 (0%) | 0% | 116.2 | 477,384 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 100.35 per share. | 11 May 2026 | 12,119 | 84,073 (0%) | 0% | 100.4 | 1,216,142 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.07 per share. | 11 May 2026 | 12,949 | 96,192 (0%) | 0% | 17.1 | 221,039 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 May 2026 | 12,949 | 0 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 101.18 per share. | 11 May 2026 | 830 | 83,243 (0%) | 0% | 101.2 | 83,979 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.46 per share. | 04 May 2026 | 6,259 | 307,444 (0%) | 0% | 30.5 | 190,649 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 May 2026 | 4,440 | 22,200 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 May 2026 | 6,259 | 31,296 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 139.60 per share. | 04 May 2026 | 381 | 301,185 (0%) | 0% | 139.6 | 53,188 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 139.09 per share. | 04 May 2026 | 1,247 | 301,566 (0%) | 0% | 139.1 | 173,445 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 137.86 per share. | 04 May 2026 | 2,721 | 302,813 (0%) | 0% | 137.9 | 375,117 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 137.01 per share. | 04 May 2026 | 5,318 | 305,534 (0%) | 0% | 137.0 | 728,619 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 135.18 per share. | 04 May 2026 | 599 | 310,852 (0%) | 0% | 135.2 | 80,973 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 134.18 per share. | 04 May 2026 | 433 | 311,451 (0%) | 0% | 134.2 | 58,100 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.16 per share. | 04 May 2026 | 4,440 | 311,884 (0%) | 0% | 17.2 | 76,190 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.46 per share. | 16 Apr 2026 | 6,259 | 307,444 (0%) | 0% | 30.5 | 190,649 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Apr 2026 | 4,440 | 26,640 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Apr 2026 | 6,259 | 37,555 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 145.79 per share. | 16 Apr 2026 | 825 | 301,185 (0%) | 0% | 145.8 | 120,277 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 144.66 per share. | 16 Apr 2026 | 2,255 | 302,010 (0%) | 0% | 144.7 | 326,208 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 143.81 per share. | 16 Apr 2026 | 5,373 | 304,265 (0%) | 0% | 143.8 | 772,691 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 142.99 per share. | 16 Apr 2026 | 2,246 | 309,638 (0%) | 0% | 143.0 | 321,156 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.16 per share. | 16 Apr 2026 | 4,440 | 311,884 (0%) | 0% | 17.2 | 76,190 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.46 per share. | 06 Apr 2026 | 6,259 | 307,444 (0%) | 0% | 30.5 | 190,649 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 164.01 per share. | 06 Apr 2026 | 1,434 | 301,185 (0%) | 0% | 164.0 | 235,190 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Apr 2026 | 6,259 | 43,814 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 163.23 per share. | 06 Apr 2026 | 8,478 | 302,619 (0%) | 0% | 163.2 | 1,383,864 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 161.73 per share. | 06 Apr 2026 | 787 | 311,097 (0%) | 0% | 161.7 | 127,282 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.16 per share. | 06 Apr 2026 | 4,440 | 311,884 (0%) | 0% | 17.2 | 76,190 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Apr 2026 | 4,440 | 31,080 | - | - | Stock Option (right to buy) | |
| Roger Adsett | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.56 per share. | 01 Apr 2026 | 88,060 | 194,870 (0%) | 0% | 14.6 | 1,282,154 | Common Stock |
| Roger Adsett | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2026 | 88,060 | 0 | - | - | Stock Option (right to buy) | |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 164.95 per share. | 01 Apr 2026 | 62,344 | 106,810 (0%) | 0% | 165.0 | 10,283,643 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 164.11 per share. | 01 Apr 2026 | 19,001 | 169,154 (0%) | 0% | 164.1 | 3,118,254 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 163.18 per share. | 01 Apr 2026 | 6,715 | 188,155 (0%) | 0% | 163.2 | 1,095,754 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Mar 2026 | 5,649 | 8,633 | - | - | Stock Option (right to buy) | |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Mar 2026 | 13,989 | 18,561 | - | - | Stock Option (right to buy) | |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.07 per share. | 30 Mar 2026 | 5,649 | 57,520 (0%) | 0% | 17.1 | 96,428 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.89 per share. | 30 Mar 2026 | 13,989 | 71,509 (0%) | 0% | 27.9 | 390,153 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 150.98 per share. | 30 Mar 2026 | 19,638 | 51,871 (0%) | 0% | 151.0 | 2,964,945 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Mar 2026 | 6,259 | 50,073 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 142.17 per share. | 19 Mar 2026 | 1,629 | 310,255 (0%) | 0% | 142.2 | 231,595 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.16 per share. | 19 Mar 2026 | 4,440 | 311,884 (0%) | 0% | 17.2 | 76,190 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 144.11 per share. | 19 Mar 2026 | 4,533 | 301,185 (0%) | 0% | 144.1 | 653,251 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.46 per share. | 19 Mar 2026 | 6,259 | 307,444 (0%) | 0% | 30.5 | 190,649 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 143.42 per share. | 19 Mar 2026 | 4,537 | 305,718 (0%) | 0% | 143.4 | 650,697 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Mar 2026 | 4,440 | 35,520 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.16 per share. | 05 Mar 2026 | 4,440 | 311,884 (0%) | 0% | 17.2 | 76,190 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2026 | 6,259 | 56,332 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 147.54 per share. | 05 Mar 2026 | 2,128 | 301,185 (0%) | 0% | 147.5 | 313,965 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 146.66 per share. | 05 Mar 2026 | 3,899 | 303,313 (0%) | 0% | 146.7 | 571,827 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 145.27 per share. | 05 Mar 2026 | 2,589 | 307,212 (0%) | 0% | 145.3 | 376,104 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 144.23 per share. | 05 Mar 2026 | 2,083 | 309,801 (0%) | 0% | 144.2 | 300,431 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.46 per share. | 05 Mar 2026 | 6,259 | 307,444 (0%) | 0% | 30.5 | 190,649 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2026 | 4,440 | 39,960 | - | - | Stock Option (right to buy) | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 03 Mar 2026 | 100 | 242,776 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 25 Feb 2026 | 1,072 | 242,876 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 25 Feb 2026 | 243 | 5,007 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 25 Feb 2026 | 243 | 3,724 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 25 Feb 2026 | 243 | 819 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 25 Feb 2026 | 243 | 5,423 (0%) | 0% | 0 | Common Stock | |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 156.53 per share. | 24 Feb 2026 | 15,771 | 51,871 (0%) | 0% | 156.5 | 2,468,635 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 155.06 per share. | 24 Feb 2026 | 4,151 | 67,642 (0%) | 0% | 155.1 | 643,654 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 153.93 per share. | 24 Feb 2026 | 4,852 | 71,793 (0%) | 0% | 153.9 | 746,868 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.07 per share. | 24 Feb 2026 | 20,248 | 76,645 (0%) | 0% | 17.1 | 345,633 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2026 | 20,248 | 14,282 | - | - | Stock Option (right to buy) | |
| David R. Brennan | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 23 Feb 2026 | 6,000 | 60,933 (0%) | 0% | 0 | Common Stock | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.46 per share. | 19 Feb 2026 | 6,259 | 307,444 (0%) | 0% | 30.5 | 190,649 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Feb 2026 | 4,440 | 44,400 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Feb 2026 | 6,259 | 62,591 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 153.38 per share. | 19 Feb 2026 | 1,030 | 301,185 (0%) | 0% | 153.4 | 157,981 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 151.92 per share. | 19 Feb 2026 | 2,377 | 302,215 (0%) | 0% | 151.9 | 361,114 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 151.12 per share. | 19 Feb 2026 | 3,413 | 304,592 (0%) | 0% | 151.1 | 515,773 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 150.10 per share. | 19 Feb 2026 | 1,891 | 308,005 (0%) | 0% | 150.1 | 283,839 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 149.17 per share. | 19 Feb 2026 | 1,988 | 309,896 (0%) | 0% | 149.2 | 296,550 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.16 per share. | 19 Feb 2026 | 4,440 | 311,884 (0%) | 0% | 17.2 | 76,190 | Common Stock |
| David W.J. McGirr | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 09 Feb 2026 | 53,400 | 44,323 (0%) | 0% | 0 | Common Stock | |
| David W.J. McGirr | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 09 Feb 2026 | 53,400 | 53,400 (0%) | 0% | 0 | Common Stock | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2026 | 4,440 | 48,840 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2026 | 6,259 | 68,850 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 148.83 per share. | 09 Feb 2026 | 1,287 | 301,185 (0%) | 0% | 148.8 | 191,544 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 148.02 per share. | 09 Feb 2026 | 7,221 | 302,472 (0%) | 0% | 148.0 | 1,068,852 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 147.17 per share. | 09 Feb 2026 | 4,888 | 309,693 (0%) | 0% | 147.2 | 719,367 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.46 per share. | 09 Feb 2026 | 6,259 | 314,581 (0%) | 0% | 30.5 | 190,649 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.16 per share. | 09 Feb 2026 | 4,440 | 308,322 (0%) | 0% | 17.2 | 76,190 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 152.44 per share. | 05 Feb 2026 | 869 | 83,243 (0%) | 0% | 152.4 | 132,470 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 156.34 per share. | 03 Feb 2026 | 3,009 | 303,882 (0%) | 0% | 156.3 | 470,427 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 156.34 per share. | 03 Feb 2026 | 748 | 79,758 (0%) | 0% | 156.3 | 116,942 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 156.17 per share. | 03 Feb 2026 | 791 | 106,810 (0%) | 0% | 156.2 | 123,530 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 156.27 per share. | 03 Feb 2026 | 640 | 56,397 (0%) | 0% | 156.3 | 100,013 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 156.86 per share. | 02 Feb 2026 | 100 | 84,907 (0%) | 0% | 156.9 | 15,686 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 155.46 per share. | 02 Feb 2026 | 3,042 | 85,007 (0%) | 0% | 155.5 | 472,909 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 154.56 per share. | 02 Feb 2026 | 3,349 | 88,049 (0%) | 0% | 154.6 | 517,621 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 153.16 per share. | 02 Feb 2026 | 928 | 91,398 (0%) | 0% | 153.2 | 142,132 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 152.06 per share. | 02 Feb 2026 | 563 | 92,326 (0%) | 0% | 152.1 | 85,610 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 65.72 per share. | 02 Feb 2026 | 7,982 | 92,889 (0%) | 0% | 65.7 | 524,577 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Feb 2026 | 7,982 | 23,948 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 155.77 per share. | 02 Feb 2026 | 795 | 84,112 (0%) | 0% | 155.8 | 123,837 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jan 2026 | 6,259 | 75,109 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 160.70 per share. | 20 Jan 2026 | 254 | 306,891 (0%) | 0% | 160.7 | 40,818 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 159.85 per share. | 20 Jan 2026 | 2,229 | 307,145 (0%) | 0% | 159.9 | 356,306 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 158.99 per share. | 20 Jan 2026 | 5,967 | 309,374 (0%) | 0% | 159.0 | 948,693 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 158.37 per share. | 20 Jan 2026 | 1,243 | 315,341 (0%) | 0% | 158.4 | 196,854 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 156.80 per share. | 20 Jan 2026 | 1,006 | 316,584 (0%) | 0% | 156.8 | 157,741 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.16 per share. | 20 Jan 2026 | 4,440 | 317,590 (0%) | 0% | 17.2 | 76,190 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.46 per share. | 20 Jan 2026 | 6,259 | 313,150 (0%) | 0% | 30.5 | 190,649 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jan 2026 | 4,440 | 53,280 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.46 per share. | 12 Jan 2026 | 6,259 | 321,666 (0%) | 0% | 30.5 | 190,649 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jan 2026 | 4,440 | 57,720 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jan 2026 | 6,259 | 81,368 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 174.86 per share. | 12 Jan 2026 | 315 | 306,891 (0%) | 0% | 174.9 | 55,081 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 172.36 per share. | 12 Jan 2026 | 297 | 307,206 (0%) | 0% | 172.4 | 51,191 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 171.31 per share. | 12 Jan 2026 | 297 | 307,503 (0%) | 0% | 171.3 | 50,879 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 170.24 per share. | 12 Jan 2026 | 160 | 307,800 (0%) | 0% | 170.2 | 27,238 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 169.57 per share. | 12 Jan 2026 | 6,996 | 307,960 (0%) | 0% | 169.6 | 1,186,312 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 168.63 per share. | 12 Jan 2026 | 7,176 | 314,956 (0%) | 0% | 168.6 | 1,210,089 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 167.73 per share. | 12 Jan 2026 | 3,974 | 322,132 (0%) | 0% | 167.7 | 666,559 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.16 per share. | 12 Jan 2026 | 4,440 | 326,106 (0%) | 0% | 17.2 | 76,190 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 186.19 per share. | 09 Jan 2026 | 1,887 | 84,907 (0%) | 0% | 186.2 | 351,341 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 173.33 per share. | 06 Jan 2026 | 4,096 | 320,987 (0%) | 0% | 173.3 | 709,960 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 174.17 per share. | 06 Jan 2026 | 3,223 | 315,407 (0%) | 0% | 174.2 | 561,350 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 175.07 per share. | 06 Jan 2026 | 2,357 | 318,630 (0%) | 0% | 175.1 | 412,640 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 175.07 per share. | 06 Jan 2026 | 1,678 | 81,953 (0%) | 0% | 175.1 | 293,767 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 174.17 per share. | 06 Jan 2026 | 1,447 | 80,506 (0%) | 0% | 174.2 | 252,024 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 173.33 per share. | 06 Jan 2026 | 1,517 | 83,631 (0%) | 0% | 173.3 | 262,942 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 174.17 per share. | 06 Jan 2026 | 2,059 | 107,601 (0%) | 0% | 174.2 | 358,616 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 173.33 per share. | 06 Jan 2026 | 1,429 | 110,462 (0%) | 0% | 173.3 | 247,689 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 175.07 per share. | 06 Jan 2026 | 802 | 109,660 (0%) | 0% | 175.1 | 140,406 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 173.47 per share. | 06 Jan 2026 | 4,783 | 98,541 (0%) | 0% | 173.5 | 829,707 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 175.01 per share. | 06 Jan 2026 | 957 | 94,754 (0%) | 0% | 175.0 | 167,485 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 174.21 per share. | 06 Jan 2026 | 2,830 | 95,711 (0%) | 0% | 174.2 | 493,014 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.43 per share. | 06 Jan 2026 | 8,570 | 103,324 (0%) | 0% | 26.4 | 226,505 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jan 2026 | 8,570 | 0 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 174.17 per share. | 06 Jan 2026 | 3,251 | 86,794 (0%) | 0% | 174.2 | 566,227 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 173.87 per share. | 06 Jan 2026 | 1,660 | 90,045 (0%) | 0% | 173.9 | 288,624 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 175.84 per share. | 06 Jan 2026 | 1,434 | 91,705 (0%) | 0% | 175.8 | 252,155 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 173.33 per share. | 06 Jan 2026 | 1,615 | 93,139 (0%) | 0% | 173.3 | 279,928 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 173.33 per share. | 06 Jan 2026 | 1,396 | 58,799 (0%) | 0% | 173.3 | 241,969 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 175.07 per share. | 06 Jan 2026 | 709 | 58,090 (0%) | 0% | 175.1 | 124,125 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 174.17 per share. | 06 Jan 2026 | 1,053 | 57,037 (0%) | 0% | 174.2 | 183,401 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 5,293 | 41,754 (0%) | 0% | - | Common Stock | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.91 per share. | 02 Jan 2026 | 87,290 | 129,044 (0%) | 0% | 13.9 | 1,214,204 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 174.28 per share. | 02 Jan 2026 | 31,030 | 98,014 (0%) | 0% | 174.3 | 5,407,908 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 175.17 per share. | 02 Jan 2026 | 34,103 | 63,911 (0%) | 0% | 175.2 | 5,973,823 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 176.08 per share. | 02 Jan 2026 | 12,832 | 51,079 (0%) | 0% | 176.1 | 2,259,459 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 177.17 per share. | 02 Jan 2026 | 9,125 | 41,954 (0%) | 0% | 177.2 | 1,616,676 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 177.78 per share. | 02 Jan 2026 | 200 | 41,754 (0%) | 0% | 177.8 | 35,556 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 27,600 | 27,600 | - | - | Stock Option (right to buy) | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2026 | 87,290 | 0 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 110,400 | 110,400 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 21,172 | 325,083 (0%) | 0% | - | Common Stock | |
| Sara M. Bonstein | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 31,280 | 31,280 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 5,998 | 79,503 (0%) | 0% | - | Common Stock | |
| Sara M. Bonstein | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 5,645 | 85,148 (0%) | 0% | - | Common Stock | |
| Roger Adsett | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 5,998 | 111,891 (0%) | 0% | - | Common Stock | |
| Roger Adsett | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 31,280 | 31,280 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 169.29 per share. | 02 Jan 2026 | 2,799 | 104,258 (0%) | 0% | 169.3 | 473,843 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 170.61 per share. | 02 Jan 2026 | 3,205 | 101,053 (0%) | 0% | 170.6 | 546,805 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 171.19 per share. | 02 Jan 2026 | 2,836 | 98,217 (0%) | 0% | 171.2 | 485,495 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 171.92 per share. | 02 Jan 2026 | 286 | 97,931 (0%) | 0% | 171.9 | 49,169 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 173.45 per share. | 02 Jan 2026 | 1,820 | 96,111 (0%) | 0% | 173.5 | 315,679 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 174.28 per share. | 02 Jan 2026 | 655 | 95,456 (0%) | 0% | 174.3 | 114,153 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 175.73 per share. | 02 Jan 2026 | 702 | 94,754 (0%) | 0% | 175.7 | 123,362 | Common Stock |
| Martina Flammer | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 31,280 | 31,280 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2026 | 4,358 | 8,715 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2026 | 7,945 | 31,780 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 5,998 | 89,109 (0%) | 0% | - | Common Stock | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.74 per share. | 02 Jan 2026 | 4,358 | 99,112 (0%) | 0% | 19.7 | 86,027 | Common Stock |
| Martina Flammer | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 5,645 | 94,754 (0%) | 0% | - | Common Stock | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.13 per share. | 02 Jan 2026 | 7,945 | 107,057 (0%) | 0% | 29.1 | 231,438 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 5,293 | 60,195 (0%) | 0% | - | Common Stock | |
| Michael A. Smith | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 27,600 | 27,600 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.16 per share. | 18 Dec 2025 | 4,440 | 308,351 (0%) | 0% | 17.2 | 76,190 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Dec 2025 | 6,259 | 87,627 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Dec 2025 | 4,440 | 62,160 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 171.20 per share. | 18 Dec 2025 | 51 | 303,911 (0%) | 0% | 171.2 | 8,731 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 170.26 per share. | 18 Dec 2025 | 362 | 303,962 (0%) | 0% | 170.3 | 61,634 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 169.58 per share. | 18 Dec 2025 | 1,938 | 304,324 (0%) | 0% | 169.6 | 328,646 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 168.54 per share. | 18 Dec 2025 | 2,175 | 306,262 (0%) | 0% | 168.5 | 366,575 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 167.29 per share. | 18 Dec 2025 | 1,431 | 308,437 (0%) | 0% | 167.3 | 239,392 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 166.60 per share. | 18 Dec 2025 | 1,783 | 309,868 (0%) | 0% | 166.6 | 297,048 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 165.21 per share. | 18 Dec 2025 | 697 | 311,651 (0%) | 0% | 165.2 | 115,151 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 164.24 per share. | 18 Dec 2025 | 447 | 312,348 (0%) | 0% | 164.2 | 73,415 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 163.19 per share. | 18 Dec 2025 | 1,465 | 312,795 (0%) | 0% | 163.2 | 239,073 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 162.26 per share. | 18 Dec 2025 | 350 | 314,260 (0%) | 0% | 162.3 | 56,791 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.46 per share. | 18 Dec 2025 | 6,259 | 314,610 (0%) | 0% | 30.5 | 190,649 | Common Stock |
| Melvin Sharoky | Director | Sale of securities on an exchange or to another person at price $ 205.01 per share. | 05 Dec 2025 | 20,000 | 243,948 (0%) | 0% | 205.0 | 4,100,200 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 207.42 per share. | 04 Dec 2025 | 1,040 | 303,911 (0%) | 0% | 207.4 | 215,717 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 206.49 per share. | 04 Dec 2025 | 2,921 | 304,951 (0%) | 0% | 206.5 | 603,157 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Dec 2025 | 4,440 | 66,600 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.16 per share. | 04 Dec 2025 | 4,440 | 314,610 (0%) | 0% | 17.2 | 76,190 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.46 per share. | 04 Dec 2025 | 6,259 | 310,170 (0%) | 0% | 30.5 | 190,649 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 205.66 per share. | 04 Dec 2025 | 2,222 | 307,872 (0%) | 0% | 205.7 | 456,977 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Dec 2025 | 6,259 | 93,886 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 204.62 per share. | 04 Dec 2025 | 4,516 | 310,094 (0%) | 0% | 204.6 | 924,064 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Dec 2025 | 8,895 | 44,475 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 25.83 per share. | 01 Dec 2025 | 8,895 | 92,006 (0%) | 0% | 25.8 | 229,758 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 205.98 per share. | 01 Dec 2025 | 1,450 | 90,556 (0%) | 0% | 206.0 | 298,671 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 207.03 per share. | 01 Dec 2025 | 5,886 | 84,670 (0%) | 0% | 207.0 | 1,218,579 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 207.73 per share. | 01 Dec 2025 | 1,559 | 83,111 (0%) | 0% | 207.7 | 323,851 | Common Stock |
| Elizabeth McKee Anderson | Director | Sale of securities on an exchange or to another person at price $ 204.58 per share. | 24 Nov 2025 | 5,000 | 58,729 (0%) | 0% | 204.6 | 1,022,900 | Common Stock |
| Leo Lee | Director | Sale of securities on an exchange or to another person at price $ 197.40 per share. | 17 Nov 2025 | 15,174 | 54,677 (0%) | 0% | 197.4 | 2,995,348 | Common Stock |
| Leo Lee | Director | Sale of securities on an exchange or to another person at price $ 196.61 per share. | 17 Nov 2025 | 24,076 | 69,851 (0%) | 0% | 196.6 | 4,733,582 | Common Stock |
| Leo Lee | Director | Sale of securities on an exchange or to another person at price $ 195.39 per share. | 17 Nov 2025 | 14,944 | 93,927 (0%) | 0% | 195.4 | 2,919,908 | Common Stock |
| Leo Lee | Director | Sale of securities on an exchange or to another person at price $ 194.49 per share. | 17 Nov 2025 | 17,594 | 108,871 (0%) | 0% | 194.5 | 3,421,857 | Common Stock |
| Leo Lee | Director | Sale of securities on an exchange or to another person at price $ 193.51 per share. | 17 Nov 2025 | 3,212 | 126,465 (0%) | 0% | 193.5 | 621,554 | Common Stock |
| Elizabeth McKee Anderson | Director | Sale of securities on an exchange or to another person at price $ 195.87 per share. | 14 Nov 2025 | 10,000 | 63,729 (0%) | 0% | 195.9 | 1,958,700 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 193.64 per share. | 12 Nov 2025 | 6,575 | 55,808 (0%) | 0% | 193.6 | 1,273,183 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 194.44 per share. | 12 Nov 2025 | 19,183 | 36,625 (0%) | 0% | 194.4 | 3,729,943 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 195.88 per share. | 12 Nov 2025 | 164 | 36,461 (0%) | 0% | 195.9 | 32,124 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Nov 2025 | 30,000 | 15,760 | - | - | Stock Option (right to buy) | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.46 per share. | 12 Nov 2025 | 30,000 | 66,461 (0%) | 0% | 26.5 | 793,800 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 192.45 per share. | 12 Nov 2025 | 4,078 | 62,383 (0%) | 0% | 192.4 | 784,811 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 188.38 per share. | 11 Nov 2025 | 5,467 | 108,870 (0%) | 0% | 188.4 | 1,029,873 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Nov 2025 | 18,277 | 54,833 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 190.33 per share. | 11 Nov 2025 | 10,622 | 86,024 (0%) | 0% | 190.3 | 2,021,685 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.95 per share. | 11 Nov 2025 | 18,277 | 114,337 (0%) | 0% | 18.9 | 346,349 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.07 per share. | 11 Nov 2025 | 12,949 | 96,060 (0%) | 0% | 17.1 | 221,039 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 191.04 per share. | 11 Nov 2025 | 2,913 | 83,111 (0%) | 0% | 191.0 | 556,500 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 189.36 per share. | 11 Nov 2025 | 12,224 | 96,646 (0%) | 0% | 189.4 | 2,314,737 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Nov 2025 | 12,949 | 12,949 | - | - | Stock Option (right to buy) | |
| David R. Brennan | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 06 Nov 2025 | 60,000 | 60,000 (0%) | 0% | 0 | Common Stock | |
| David R. Brennan | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 06 Nov 2025 | 60,000 | 66,933 (0%) | 0% | 0 | Common Stock | |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 184.91 per share. | 03 Nov 2025 | 3,243 | 61,510 (0%) | 0% | 184.9 | 599,663 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 183.92 per share. | 03 Nov 2025 | 4,032 | 64,753 (0%) | 0% | 183.9 | 741,565 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 182.60 per share. | 03 Nov 2025 | 4,286 | 68,785 (0%) | 0% | 182.6 | 782,624 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 181.88 per share. | 03 Nov 2025 | 7,619 | 73,071 (0%) | 0% | 181.9 | 1,385,744 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 181.01 per share. | 03 Nov 2025 | 1,342 | 80,690 (0%) | 0% | 181.0 | 242,915 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.75 per share. | 03 Nov 2025 | 27,130 | 82,032 (0%) | 0% | 23.8 | 644,338 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Nov 2025 | 27,130 | 0 | - | - | Stock Option (right to buy) | |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 187.97 per share. | 03 Nov 2025 | 1,400 | 54,902 (0%) | 0% | 188.0 | 263,158 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 187.15 per share. | 03 Nov 2025 | 1,572 | 56,302 (0%) | 0% | 187.2 | 294,200 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 185.93 per share. | 03 Nov 2025 | 3,636 | 57,874 (0%) | 0% | 185.9 | 676,041 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.75 per share. | 12 Sep 2025 | 56,520 | 112,981 (0%) | 0% | 23.8 | 1,342,350 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Sep 2025 | 56,520 | 0 | - | - | Stock Option (right to buy) | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 147.46 per share. | 12 Sep 2025 | 6,158 | 36,461 (0%) | 0% | 147.5 | 908,059 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 146.57 per share. | 12 Sep 2025 | 7,304 | 42,619 (0%) | 0% | 146.6 | 1,070,547 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 145.67 per share. | 12 Sep 2025 | 30,967 | 49,923 (0%) | 0% | 145.7 | 4,510,963 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 144.60 per share. | 12 Sep 2025 | 32,091 | 80,890 (0%) | 0% | 144.6 | 4,640,359 | Common Stock |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 11 Sep 2025 | 159 | 741 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 11 Sep 2025 | 2,000 | 272,516 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Sale of securities on an exchange or to another person at price $ 145.39 per share. | 11 Sep 2025 | 10,000 | 262,675 (0%) | 0% | 145.4 | 1,453,900 | Common Stock |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 11 Sep 2025 | 159 | 272,675 (0%) | 0% | 0 | Common Stock | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 04 Sep 2025 | 23,303 | 56,461 (0%) | 0% | 0 | Common Stock | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 34.03 per share. | 02 Sep 2025 | 13,680 | 96,791 (0%) | 0% | 34.0 | 465,530 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 17,790 | 53,370 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 23,835 | 39,725 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 36,555 | 73,110 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 13,072 | 13,073 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 38,846 | 25,898 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 25,710 | 8,570 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 17,160 | 0 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 13,680 | 0 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 146.05 per share. | 02 Sep 2025 | 34,615 | 83,111 (0%) | 0% | 146.1 | 5,055,521 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 145.33 per share. | 02 Sep 2025 | 63,782 | 117,726 (0%) | 0% | 145.3 | 9,269,438 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 144.05 per share. | 02 Sep 2025 | 28,063 | 181,508 (0%) | 0% | 144.0 | 4,042,475 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 143.16 per share. | 02 Sep 2025 | 35,245 | 209,571 (0%) | 0% | 143.2 | 5,045,674 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 142.03 per share. | 02 Sep 2025 | 5,877 | 244,816 (0%) | 0% | 142.0 | 834,710 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 141.27 per share. | 02 Sep 2025 | 19,066 | 250,693 (0%) | 0% | 141.3 | 2,693,454 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 25.83 per share. | 02 Sep 2025 | 17,790 | 269,759 (0%) | 0% | 25.8 | 459,516 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.13 per share. | 02 Sep 2025 | 23,835 | 251,969 (0%) | 0% | 29.1 | 694,314 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.95 per share. | 02 Sep 2025 | 36,555 | 228,134 (0%) | 0% | 18.9 | 692,717 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.74 per share. | 02 Sep 2025 | 13,072 | 191,579 (0%) | 0% | 19.7 | 258,041 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.07 per share. | 02 Sep 2025 | 38,846 | 178,507 (0%) | 0% | 17.1 | 663,101 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.43 per share. | 02 Sep 2025 | 25,710 | 139,661 (0%) | 0% | 26.4 | 679,515 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.46 per share. | 02 Sep 2025 | 17,160 | 113,951 (0%) | 0% | 26.5 | 454,054 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 141.16 per share. | 02 Sep 2025 | 1,354 | 77,820 (0%) | 0% | 141.2 | 191,131 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 12,780 | 0 | - | - | Stock Option (right to buy) | |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 145.89 per share. | 02 Sep 2025 | 1,183 | 54,902 (0%) | 0% | 145.9 | 172,588 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 145.18 per share. | 02 Sep 2025 | 4,944 | 56,085 (0%) | 0% | 145.2 | 717,770 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 144.16 per share. | 02 Sep 2025 | 8,300 | 61,029 (0%) | 0% | 144.2 | 1,196,528 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 143.16 per share. | 02 Sep 2025 | 7,391 | 69,329 (0%) | 0% | 143.2 | 1,058,096 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 142.06 per share. | 02 Sep 2025 | 1,100 | 76,720 (0%) | 0% | 142.1 | 156,266 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.46 per share. | 02 Sep 2025 | 12,780 | 79,174 (0%) | 0% | 30.5 | 389,279 | Common Stock |
| Melvin Sharoky | Director | Sale of securities on an exchange or to another person at price $ 129.50 per share. | 20 Aug 2025 | 10,000 | 274,516 (0%) | 0% | 129.5 | 1,295,000 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 128.27 per share. | 19 Aug 2025 | 4,807 | 105,637 (0%) | 0% | 128.3 | 616,594 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 127.42 per share. | 19 Aug 2025 | 20,193 | 110,444 (0%) | 0% | 127.4 | 2,572,992 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 129.47 per share. | 18 Aug 2025 | 1,416 | 233,924 (0%) | 0% | 129.5 | 183,330 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 128.76 per share. | 18 Aug 2025 | 2,481 | 235,340 (0%) | 0% | 128.8 | 319,454 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 127.59 per share. | 18 Aug 2025 | 2,968 | 237,821 (0%) | 0% | 127.6 | 378,687 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 18 Aug 2025 | 6,865 | 240,789 (0%) | 0% | 10.8 | 74,485 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Aug 2025 | 6,865 | 0 | - | - | Stock Option (right to buy) | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 127.71 per share. | 14 Aug 2025 | 5,746 | 80,464 (0%) | 0% | 127.7 | 733,822 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 126.57 per share. | 14 Aug 2025 | 3,554 | 86,210 (0%) | 0% | 126.6 | 449,830 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 128.16 per share. | 14 Aug 2025 | 700 | 79,764 (0%) | 0% | 128.2 | 89,712 | Common Stock |
| Melvin Sharoky | Director | Sale of securities on an exchange or to another person at price $ 121.58 per share. | 12 Aug 2025 | 10,000 | 290,616 (0%) | 0% | 121.6 | 1,215,800 | Common Stock |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 12 Aug 2025 | 5,000 | 6,847 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 12 Aug 2025 | 15,000 | 900 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 12 Aug 2025 | 6,100 | 284,516 (0%) | 0% | 0 | Common Stock | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 04 Aug 2025 | 6,830 | 240,754 (0%) | 0% | 10.9 | 74,106 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Aug 2025 | 6,830 | 6,865 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 110.91 per share. | 04 Aug 2025 | 1,938 | 233,924 (0%) | 0% | 110.9 | 214,944 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 109.68 per share. | 04 Aug 2025 | 3,199 | 235,862 (0%) | 0% | 109.7 | 350,866 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 108.80 per share. | 04 Aug 2025 | 1,693 | 239,061 (0%) | 0% | 108.8 | 184,198 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 109.50 per share. | 04 Aug 2025 | 8,715 | 83,111 (0%) | 0% | 109.5 | 954,293 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Aug 2025 | 8,715 | 26,145 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.74 per share. | 04 Aug 2025 | 8,715 | 91,826 (0%) | 0% | 19.7 | 172,034 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.46 per share. | 21 Jul 2025 | 3,443 | 87,460 (0%) | 0% | 26.5 | 91,102 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 103.03 per share. | 21 Jul 2025 | 26,310 | 73,505 (0%) | 0% | 103.0 | 2,710,719 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jul 2025 | 3,443 | 8,580 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jul 2025 | 11,455 | 0 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jul 2025 | 15,890 | 47,670 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jul 2025 | 17,100 | 0 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 102.38 per share. | 21 Jul 2025 | 32,090 | 99,815 (0%) | 0% | 102.4 | 3,285,374 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 34.03 per share. | 21 Jul 2025 | 17,100 | 131,905 (0%) | 0% | 34.0 | 581,913 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.13 per share. | 21 Jul 2025 | 15,890 | 114,805 (0%) | 0% | 29.1 | 462,876 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 28.88 per share. | 21 Jul 2025 | 11,455 | 98,915 (0%) | 0% | 28.9 | 330,820 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 6,830 | 13,695 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 102.66 per share. | 15 Jul 2025 | 4,492 | 234,094 (0%) | 0% | 102.7 | 461,149 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 103.32 per share. | 15 Jul 2025 | 170 | 233,924 (0%) | 0% | 103.3 | 17,564 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 101.71 per share. | 15 Jul 2025 | 2,168 | 238,586 (0%) | 0% | 101.7 | 220,507 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 15 Jul 2025 | 6,830 | 240,754 (0%) | 0% | 10.9 | 74,106 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 102.51 per share. | 11 Jul 2025 | 933 | 66,394 (0%) | 0% | 102.5 | 95,642 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 96.41 per share. | 11 Jul 2025 | 748 | 67,327 (0%) | 0% | 96.4 | 72,115 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.74 per share. | 07 Jul 2025 | 6,244 | 100,137 (0%) | 0% | 19.7 | 123,257 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jul 2025 | 6,244 | 18,880 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jul 2025 | 4,362 | 0 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jul 2025 | 23,565 | 15,710 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jul 2025 | 13,717 | 12,023 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 96.19 per share. | 07 Jul 2025 | 22,181 | 84,017 (0%) | 0% | 96.2 | 2,133,590 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 95.66 per share. | 07 Jul 2025 | 35,583 | 106,198 (0%) | 0% | 95.7 | 3,403,870 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.46 per share. | 07 Jul 2025 | 13,717 | 141,781 (0%) | 0% | 26.5 | 362,952 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.43 per share. | 07 Jul 2025 | 23,565 | 128,064 (0%) | 0% | 26.4 | 622,823 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.70 per share. | 07 Jul 2025 | 4,362 | 104,499 (0%) | 0% | 24.7 | 107,741 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 01 Jul 2025 | 6,830 | 240,754 (0%) | 0% | 10.9 | 74,106 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2025 | 6,830 | 20,525 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 99.61 per share. | 01 Jul 2025 | 815 | 233,924 (0%) | 0% | 99.6 | 81,182 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 98.83 per share. | 01 Jul 2025 | 2,349 | 234,739 (0%) | 0% | 98.8 | 232,152 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 97.73 per share. | 01 Jul 2025 | 3,666 | 237,088 (0%) | 0% | 97.7 | 358,278 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.95 per share. | 23 Jun 2025 | 35,253 | 138,665 (0%) | 0% | 18.9 | 668,044 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jun 2025 | 12,636 | 25,124 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jun 2025 | 35,253 | 99,007 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 102.15 per share. | 23 Jun 2025 | 8,661 | 93,536 (0%) | 0% | 102.1 | 884,721 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 101.71 per share. | 23 Jun 2025 | 49,104 | 102,197 (0%) | 0% | 101.7 | 4,994,368 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.74 per share. | 23 Jun 2025 | 12,636 | 151,301 (0%) | 0% | 19.7 | 249,435 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 99.65 per share. | 16 Jun 2025 | 1,558 | 306,758 (0%) | 0% | 99.7 | 155,255 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 100.70 per share. | 16 Jun 2025 | 2,300 | 304,458 (0%) | 0% | 100.7 | 231,610 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 98.51 per share. | 16 Jun 2025 | 442 | 308,316 (0%) | 0% | 98.5 | 43,541 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2025 | 129,805 | 27,355 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 101.23 per share. | 16 Jun 2025 | 41,784 | 233,924 (0%) | 0% | 101.2 | 4,229,794 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 100.54 per share. | 16 Jun 2025 | 48,531 | 275,708 (0%) | 0% | 100.5 | 4,879,307 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 99.51 per share. | 16 Jun 2025 | 32,490 | 324,239 (0%) | 0% | 99.5 | 3,233,080 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 98.50 per share. | 16 Jun 2025 | 7,000 | 356,729 (0%) | 0% | 98.5 | 689,500 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 16 Jun 2025 | 129,805 | 363,729 (0%) | 0% | 10.8 | 1,408,384 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 101.39 per share. | 16 Jun 2025 | 904 | 303,554 (0%) | 0% | 101.4 | 91,657 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 99.32 per share. | 16 Jun 2025 | 4,186 | 130,637 (0%) | 0% | 99.3 | 415,754 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 98.50 per share. | 16 Jun 2025 | 6,500 | 134,823 (0%) | 0% | 98.5 | 640,250 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 90.93 per share. | 10 Jun 2025 | 6,328 | 103,512 (0%) | 0% | 90.9 | 575,405 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 89.85 per share. | 10 Jun 2025 | 15,825 | 109,840 (0%) | 0% | 89.8 | 1,421,876 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 88.99 per share. | 10 Jun 2025 | 20,926 | 125,665 (0%) | 0% | 89.0 | 1,862,205 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 88.29 per share. | 10 Jun 2025 | 7,310 | 146,591 (0%) | 0% | 88.3 | 645,400 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 87.12 per share. | 10 Jun 2025 | 7,277 | 153,901 (0%) | 0% | 87.1 | 633,972 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.07 per share. | 10 Jun 2025 | 23,740 | 161,178 (0%) | 0% | 17.1 | 405,242 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.95 per share. | 10 Jun 2025 | 24,150 | 137,438 (0%) | 0% | 19.0 | 457,643 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 23,740 | 35,610 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 24,150 | 134,260 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 91.66 per share. | 10 Jun 2025 | 100 | 103,412 (0%) | 0% | 91.7 | 9,166 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 19,423 | 64,744 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 25,740 | 17,160 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 94.50 per share. | 10 Jun 2025 | 19,423 | 83,111 (0%) | 0% | 94.5 | 1,835,474 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.07 per share. | 10 Jun 2025 | 19,423 | 102,534 (0%) | 0% | 17.1 | 331,551 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 88.64 per share. | 10 Jun 2025 | 25,740 | 83,111 (0%) | 0% | 88.6 | 2,281,594 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.46 per share. | 10 Jun 2025 | 25,740 | 108,851 (0%) | 0% | 26.5 | 681,080 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.16 per share. | 10 Jun 2025 | 38,300 | 156,879 (0%) | 0% | 17.2 | 657,228 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 70,000 | 87,290 | - | - | Stock Option (right to buy) | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 38,300 | 0 | - | - | Stock Option (right to buy) | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 92.73 per share. | 10 Jun 2025 | 18,319 | 135,188 (0%) | 0% | 92.7 | 1,698,721 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 96.02 per share. | 10 Jun 2025 | 500 | 89,407 (0%) | 0% | 96.0 | 48,010 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 95.49 per share. | 10 Jun 2025 | 34,500 | 89,907 (0%) | 0% | 95.5 | 3,294,405 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 93.48 per share. | 10 Jun 2025 | 10,781 | 124,407 (0%) | 0% | 93.5 | 1,007,808 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 91.68 per share. | 10 Jun 2025 | 35,072 | 153,507 (0%) | 0% | 91.7 | 3,215,401 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.91 per share. | 10 Jun 2025 | 70,000 | 188,579 (0%) | 0% | 13.9 | 973,700 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 88.64 per share. | 10 Jun 2025 | 38,300 | 118,579 (0%) | 0% | 88.6 | 3,394,912 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 73.50 per share. | 05 Jun 2025 | 1,879 | 67,718 (0%) | 0% | 73.5 | 138,107 | Common Stock |
| David W.J. McGirr | Director | 03 Jun 2025 | 3,000 | 97,723 (0%) | 0% | 73.3 | 219,810 | Common Stock | |
| David W.J. McGirr | Director | 03 Jun 2025 | 3,250 | 100,723 (0%) | 0% | 71.3 | 231,725 | Common Stock | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 71.50 per share. | 03 Jun 2025 | 1,642 | 118,579 (0%) | 0% | 71.5 | 117,403 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 71.50 per share. | 03 Jun 2025 | 1,579 | 113,288 (0%) | 0% | 71.5 | 112,899 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 71.50 per share. | 03 Jun 2025 | 1,860 | 141,323 (0%) | 0% | 71.5 | 132,990 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 71.50 per share. | 03 Jun 2025 | 1,686 | 83,111 (0%) | 0% | 71.5 | 120,549 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 71.50 per share. | 03 Jun 2025 | 1,448 | 69,597 (0%) | 0% | 71.5 | 103,532 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 02 Jun 2025 | 6,830 | 240,754 (0%) | 0% | 10.9 | 74,106 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jun 2025 | 6,830 | 157,160 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 71.50 per share. | 02 Jun 2025 | 5,472 | 308,758 (0%) | 0% | 71.5 | 391,248 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 71.94 per share. | 02 Jun 2025 | 1,430 | 233,924 (0%) | 0% | 71.9 | 102,874 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 71.35 per share. | 02 Jun 2025 | 4,400 | 235,354 (0%) | 0% | 71.4 | 313,940 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 70.23 per share. | 02 Jun 2025 | 1,000 | 239,754 (0%) | 0% | 70.2 | 70,230 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 70.00 per share. | 30 May 2025 | 20,000 | 71,045 (0%) | 0% | 70 | 1,400,000 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 68.56 per share. | 30 May 2025 | 6,327 | 91,045 (0%) | 0% | 68.6 | 433,779 | Common Stock |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 27 May 2025 | 200 | 300,616 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 20 May 2025 | 400 | 300,816 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 20 May 2025 | 100 | 100 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 20 May 2025 | 100 | 100 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 20 May 2025 | 100 | 100 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 20 May 2025 | 100 | 100 (0%) | 0% | 0 | Common Stock | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 May 2025 | 6,830 | 163,990 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 68.54 per share. | 20 May 2025 | 1,716 | 233,924 (0%) | 0% | 68.5 | 117,615 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 68.13 per share. | 20 May 2025 | 2,251 | 235,640 (0%) | 0% | 68.1 | 153,361 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 66.90 per share. | 20 May 2025 | 2,863 | 237,891 (0%) | 0% | 66.9 | 191,535 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 20 May 2025 | 6,830 | 240,754 (0%) | 0% | 10.9 | 74,106 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 68.49 per share. | 20 May 2025 | 7,088 | 314,230 (0%) | 0% | 68.5 | 485,457 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 67.96 per share. | 20 May 2025 | 4,480 | 321,318 (0%) | 0% | 68.0 | 304,461 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 66.87 per share. | 20 May 2025 | 9,489 | 325,798 (0%) | 0% | 66.9 | 634,529 | Common Stock |
| Clarissa Desjardins | Director | Purchase of securities on an exchange or from another person at price $ 66.87 per share. | 20 May 2025 | 1,895 | 1,895 (0%) | 0% | 66.9 | 126,719 | Common Stock |
| Clarissa Desjardins | Director | Purchase of securities on an exchange or from another person at price $ 66.35 per share. | 20 May 2025 | 1,130 | 3,025 (0%) | 0% | 66.4 | 74,976 | Common Stock |
| Carol A. Schafer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 5,058 | 63,317 (0%) | 0% | - | Common Stock | |
| David W.J. McGirr | Director | 15 May 2025 | 5,058 | 103,973 (0%) | 0% | - | Common Stock | ||
| Melvin Sharoky | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 5,058 | 301,216 (0%) | 0% | - | Common Stock | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 5,578 | 120,221 (0%) | 0% | 0 | Common Stock | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 27,100 | 27,100 | - | - | Stock Option (right to buy) | |
| David R. Brennan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 5,058 | 126,933 (0%) | 0% | - | Common Stock | |
| William H. Lewis | Director, Chair and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 22,314 | 335,287 (0%) | 0% | 0 | Common Stock | |
| William H. Lewis | Director, Chair and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 108,380 | 108,380 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 31,610 | 31,610 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 6,508 | 114,867 (0%) | 0% | 0 | Common Stock | |
| Roger Adsett | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 6,508 | 143,183 (0%) | 0% | 0 | Common Stock | |
| Roger Adsett | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 31,610 | 31,610 | - | - | Stock Option (right to buy) | |
| Clarissa Desjardins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 5,058 | 67,007 (0%) | 0% | - | Common Stock | |
| Leo Lee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 5,058 | 129,677 (0%) | 0% | - | Common Stock | |
| Elizabeth McKee Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 5,058 | 73,729 (0%) | 0% | - | Common Stock | |
| Martina Flammer | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 31,610 | 31,610 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 67.53 per share. | 15 May 2025 | 1,799 | 84,797 (0%) | 0% | 67.5 | 121,486 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 65.47 per share. | 15 May 2025 | 9,925 | 86,596 (0%) | 0% | 65.5 | 649,790 | Common Stock |
| Martina Flammer | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 6,508 | 96,521 (0%) | 0% | 0 | Common Stock | |
| Michael A. Smith | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 5,578 | 97,372 (0%) | 0% | 0 | Common Stock | |
| Michael A. Smith | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 27,100 | 27,100 | - | - | Stock Option (right to buy) | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 14 May 2025 | 576 | 576 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 14 May 2025 | 576 | 296,158 (0%) | 0% | 0 | Common Stock |