XNAS 14 Nov, 2025 4:30 PM (EST)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Brian Birchler | EVP, Corp and Development Ops | Sale of securities on an exchange or to another person at price $ 76.17 per share. | 06 Nov 2025 | 8,000 | 48,826 (0%) | 0% | 76.2 | 609,379 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 76.10 per share. | 05 Nov 2025 | 14,738 | 59,657 (0%) | 0% | 76.1 | 1,121,521 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 05 Nov 2025 | 14,738 | 74,395 (0%) | 0% | 56.8 | 836,824 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.01 per share. | 05 Nov 2025 | 801 | 59,657 (0%) | 0% | 75.0 | 60,083 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 05 Nov 2025 | 801 | 60,458 (0%) | 0% | 60.9 | 48,773 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.01 per share. | 05 Nov 2025 | 800 | 59,657 (0%) | 0% | 75.0 | 60,008 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 05 Nov 2025 | 800 | 60,457 (0%) | 0% | 56.8 | 45,424 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Nov 2025 | 18,300 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Nov 2025 | 801 | 18,300 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Nov 2025 | 14,738 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Nov 2025 | 800 | 14,738 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 05 Nov 2025 | 18,300 | 77,957 (0%) | 0% | 60.9 | 1,114,287 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.42 per share. | 05 Nov 2025 | 18,300 | 59,657 (0%) | 0% | 75.4 | 1,380,204 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.05 per share. | 03 Nov 2025 | 905 | 59,657 (0%) | 0% | 75.1 | 67,924 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Nov 2025 | 905 | 15,538 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 03 Nov 2025 | 905 | 60,562 (0%) | 0% | 56.8 | 51,386 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.05 per share. | 03 Nov 2025 | 775 | 59,657 (0%) | 0% | 75.1 | 58,167 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Nov 2025 | 775 | 19,101 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 03 Nov 2025 | 775 | 60,432 (0%) | 0% | 60.9 | 47,190 | Common Stock |
| Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.22 per share. | 31 Oct 2025 | 16,000 | 52,330 (0%) | 0% | 52.2 | 835,520 | Common Stock |
| Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Oct 2025 | 16,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Loscalzo | Director | Sale of securities on an exchange or to another person at price $ 75.10 per share. | 31 Oct 2025 | 16,000 | 36,330 (0%) | 0% | 75.1 | 1,201,669 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Oct 2025 | 34,585 | 19,876 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Oct 2025 | 34,664 | 16,443 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.05 per share. | 31 Oct 2025 | 905 | 59,657 (0%) | 0% | 75.1 | 67,924 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 31 Oct 2025 | 905 | 60,562 (0%) | 0% | 60.9 | 55,105 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.05 per share. | 31 Oct 2025 | 775 | 59,657 (0%) | 0% | 75.1 | 58,167 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 31 Oct 2025 | 775 | 60,432 (0%) | 0% | 56.8 | 44,005 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.11 per share. | 31 Oct 2025 | 20,000 | 59,657 (0%) | 0% | 75.1 | 1,502,166 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.11 per share. | 31 Oct 2025 | 34,664 | 79,657 (0%) | 0% | 75.1 | 2,603,554 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 31 Oct 2025 | 34,664 | 114,321 (0%) | 0% | 56.8 | 1,968,222 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.11 per share. | 31 Oct 2025 | 34,585 | 79,657 (0%) | 0% | 75.1 | 2,597,621 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 31 Oct 2025 | 34,585 | 114,242 (0%) | 0% | 60.9 | 2,105,881 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Oct 2025 | 905 | 18,971 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Oct 2025 | 775 | 15,668 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 73.16 per share. | 30 Oct 2025 | 8,341 | 81,210 (0%) | 0% | 73.2 | 610,228 | Common Stock |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 72.19 per share. | 30 Oct 2025 | 2,484 | 89,551 (0%) | 0% | 72.2 | 179,320 | Common Stock |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 75.16 per share. | 30 Oct 2025 | 11,200 | 64,035 (0%) | 0% | 75.2 | 841,776 | Common Stock |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 73.85 per share. | 30 Oct 2025 | 5,975 | 75,235 (0%) | 0% | 73.9 | 441,254 | Common Stock |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 71.74 per share. | 15 Oct 2025 | 5,000 | 61,344 (0%) | 0% | 71.7 | 358,722 | Common Stock |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2025 | 125 | 497 | - | - | Restricted Stock Unit | |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 73.62 per share. | 15 Oct 2025 | 53 | 256 (0%) | 0% | 73.6 | 3,902 | Common Stock |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2025 | 125 | 309 (0%) | 0% | 0 | Common Stock | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 48.51 per share. | 15 Oct 2025 | 6,000 | 21,937 (0%) | 0% | 48.5 | 291,060 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2025 | 2,820 | 60,406 | - | - | Restricted Stock Unit | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2025 | 6,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Sale of securities on an exchange or to another person at price $ 73.62 per share. | 15 Oct 2025 | 1,263 | 17,494 (0%) | 0% | 73.6 | 92,984 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2025 | 2,820 | 18,757 (0%) | 0% | 0 | Common Stock | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Sale of securities on an exchange or to another person at price $ 72.94 per share. | 15 Oct 2025 | 6,000 | 15,937 (0%) | 0% | 72.9 | 437,654 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2025 | 12,425 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2025 | 11,475 | 12,425 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brian Birchler | EVP, Corp and Development Ops | Sale of securities on an exchange or to another person at price $ 72.23 per share. | 14 Oct 2025 | 12,425 | 56,826 (0%) | 0% | 72.2 | 897,398 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 14 Oct 2025 | 12,425 | 69,251 (0%) | 0% | 53.8 | 668,092 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Sale of securities on an exchange or to another person at price $ 72.03 per share. | 14 Oct 2025 | 11,475 | 56,826 (0%) | 0% | 72.0 | 826,589 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 14 Oct 2025 | 11,475 | 68,301 (0%) | 0% | 53.8 | 617,011 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 69.26 per share. | 06 Oct 2025 | 437 | 179,572 (0%) | 0% | 69.3 | 30,268 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.87 per share. | 06 Oct 2025 | 10,200 | 67,330 (0%) | 0% | 52.9 | 539,274 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 69.89 per share. | 06 Oct 2025 | 10,200 | 57,130 (0%) | 0% | 69.9 | 712,849 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 69.27 per share. | 06 Oct 2025 | 3,241 | 53,889 (0%) | 0% | 69.3 | 224,488 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Oct 2025 | 10,200 | 17,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 69.02 per share. | 06 Oct 2025 | 6,849 | 30,453 (0%) | 0% | 69.0 | 472,718 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 69.37 per share. | 06 Oct 2025 | 1,625 | 30,301 (0%) | 0% | 69.4 | 112,725 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 67.69 per share. | 02 Oct 2025 | 30,203 | 57,130 (0%) | 0% | 67.7 | 2,044,417 | Common Stock |
| R. Patrick O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 67.69 per share. | 02 Oct 2025 | 34,461 | 57,130 (0%) | 0% | 67.7 | 2,332,638 | Common Stock |
| O'Neil R. Patrick | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Oct 2025 | 30,203 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Baroldi Joseph T. | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.80 per share. | 02 Oct 2025 | 15,000 | 46,926 (0%) | 0% | 31.8 | 477,000 | Common Stock |
| Patrick O'Neil R. | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Oct 2025 | 34,461 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| O'Neil R. Patrick | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 02 Oct 2025 | 30,203 | 87,333 (0%) | 0% | 56.8 | 1,714,926 | Common Stock |
| Joseph Baroldi T. | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Oct 2025 | 15,000 | 26,700 | - | - | Non-Qualified Stock Option (right to buy) | |
| R. Patrick O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 02 Oct 2025 | 34,461 | 91,591 (0%) | 0% | 60.9 | 2,098,330 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 68.01 per share. | 02 Oct 2025 | 15,000 | 31,926 (0%) | 0% | 68.0 | 1,020,210 | Common Stock |
| Swayze Eric E. | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2025 | 12,972 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 66.09 per share. | 01 Oct 2025 | 14,142 | 37,302 (0%) | 0% | 66.1 | 934,662 | Common Stock |
| E. Eric Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 66.23 per share. | 01 Oct 2025 | 12,972 | 37,302 (0%) | 0% | 66.2 | 859,082 | Common Stock |
| Wender Joseph H. | Director | Sale of securities on an exchange or to another person at price $ 65.50 per share. | 01 Oct 2025 | 16,800 | 92,035 (0%) | 0% | 65.5 | 1,100,385 | Common Stock |
| Swayze Eric E. | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 01 Oct 2025 | 12,972 | 50,274 (0%) | 0% | 53.8 | 697,504 | Common Stock |
| E. Eric Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 01 Oct 2025 | 14,142 | 51,444 (0%) | 0% | 53.8 | 760,415 | Common Stock |
| Swayze Eric E. | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2025 | 14,142 | 12,972 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 30 Sep 2025 | 57,900 | 137,557 (0%) | 0% | 53.8 | 3,113,283 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Sep 2025 | 57,900 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 65.24 per share. | 30 Sep 2025 | 57,900 | 79,657 (0%) | 0% | 65.2 | 3,777,668 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 30 Sep 2025 | 49,800 | 160,300 (0%) | 0% | 53.8 | 2,677,746 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Sale of securities on an exchange or to another person at price $ 65.26 per share. | 30 Sep 2025 | 49,800 | 110,500 (0%) | 0% | 65.3 | 3,249,734 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Sep 2025 | 49,800 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Sep 2025 | 14,827 | 30,203 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 64.54 per share. | 29 Sep 2025 | 10,473 | 57,130 (0%) | 0% | 64.5 | 675,945 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 29 Sep 2025 | 10,473 | 67,603 (0%) | 0% | 56.8 | 594,657 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 29 Sep 2025 | 14,827 | 71,957 (0%) | 0% | 56.8 | 841,877 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Sep 2025 | 10,473 | 45,030 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 64.68 per share. | 29 Sep 2025 | 14,827 | 57,130 (0%) | 0% | 64.7 | 958,976 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 64.58 per share. | 12 Sep 2025 | 1,700 | 57,130 (0%) | 0% | 64.6 | 109,787 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Sep 2025 | 1,700 | 55,503 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 12 Sep 2025 | 1,700 | 58,830 (0%) | 0% | 56.8 | 96,526 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 09 Sep 2025 | 20,000 | 77,130 (0%) | 0% | 60.9 | 1,217,800 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Sep 2025 | 20,000 | 34,461 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Sep 2025 | 1,000 | 57,203 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 64.56 per share. | 09 Sep 2025 | 1,000 | 57,130 (0%) | 0% | 64.6 | 64,555 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 09 Sep 2025 | 1,000 | 58,130 (0%) | 0% | 56.8 | 56,780 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 64.56 per share. | 09 Sep 2025 | 20,000 | 57,130 (0%) | 0% | 64.6 | 1,291,106 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.80 per share. | 09 Sep 2025 | 11,950 | 43,876 (0%) | 0% | 31.8 | 380,010 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 62.16 per share. | 09 Sep 2025 | 11,950 | 31,926 (0%) | 0% | 62.2 | 742,838 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Sep 2025 | 11,950 | 41,700 | - | - | Non-Qualified Stock Option (right to buy) | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 59.60 per share. | 05 Sep 2025 | 6,000 | 82,679 (0%) | 0% | 59.6 | 357,581 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.80 per share. | 05 Sep 2025 | 250 | 32,176 (0%) | 0% | 31.8 | 7,950 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 62.00 per share. | 05 Sep 2025 | 250 | 31,926 (0%) | 0% | 62 | 15,500 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Sep 2025 | 250 | 53,650 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 60.00 per share. | 03 Sep 2025 | 28,000 | 0 (0%) | 0% | 60 | 1,680,000 | Common Stock |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 16,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 12,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 60.00 per share. | 03 Sep 2025 | 28,000 | 0 (0%) | 0% | 60 | 1,680,000 | Common Stock |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 12,000 | 28,000 (0%) | 0% | 0 | Common Stock | |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 16,000 | 16,000 (0%) | 0% | 0 | Common Stock | |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 16,000 | 16,000 (0%) | 0% | 0 | Common Stock | |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 12,000 | 28,000 (0%) | 0% | 0 | Common Stock | |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 16,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 12,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.42 per share. | 03 Sep 2025 | 16,000 | 52,330 (0%) | 0% | 24.4 | 390,720 | Common Stock |
| Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 16,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Loscalzo | Director | Sale of securities on an exchange or to another person at price $ 60.15 per share. | 03 Sep 2025 | 16,000 | 36,330 (0%) | 0% | 60.1 | 962,371 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.58 per share. | 03 Sep 2025 | 42,030 | 308,324 (0%) | 0% | 37.6 | 1,579,487 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 03 Sep 2025 | 102,900 | 282,909 (0%) | 0% | 53.8 | 5,532,933 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 102,900 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 42,030 | 76,643 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 27,568 | 40,173 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 31,316 | 67,741 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 61.06 per share. | 03 Sep 2025 | 59,699 | 180,009 (0%) | 0% | 61.1 | 3,645,394 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 03 Sep 2025 | 27,568 | 239,708 (0%) | 0% | 32.6 | 898,717 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 03 Sep 2025 | 31,316 | 212,140 (0%) | 0% | 32.6 | 1,020,902 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 60.13 per share. | 03 Sep 2025 | 127,500 | 180,824 (0%) | 0% | 60.1 | 7,667,047 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 59.12 per share. | 03 Sep 2025 | 16,615 | 266,294 (0%) | 0% | 59.1 | 982,262 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 15,000 | 68,900 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 15,000 | 53,900 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.80 per share. | 03 Sep 2025 | 2,800 | 34,726 (0%) | 0% | 31.8 | 89,040 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 62.01 per share. | 03 Sep 2025 | 2,800 | 31,926 (0%) | 0% | 62.0 | 173,628 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.80 per share. | 03 Sep 2025 | 15,000 | 46,926 (0%) | 0% | 31.8 | 477,000 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 59.09 per share. | 03 Sep 2025 | 30,000 | 16,926 (0%) | 0% | 59.1 | 1,772,592 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 2,800 | 83,900 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.80 per share. | 03 Sep 2025 | 15,000 | 31,926 (0%) | 0% | 31.8 | 477,000 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 19,658 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 61.42 per share. | 03 Sep 2025 | 7,203 | 51,507 (0%) | 0% | 61.4 | 442,382 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 60.46 per share. | 03 Sep 2025 | 12,455 | 58,710 (0%) | 0% | 60.5 | 753,039 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 03 Sep 2025 | 19,658 | 71,165 (0%) | 0% | 53.8 | 1,057,011 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Sale of securities on an exchange or to another person at price $ 61.02 per share. | 03 Sep 2025 | 3,162 | 15,009 (0%) | 0% | 61.0 | 192,943 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 928 | 13,440 | - | - | Non-Qualified Stock Option (right to buy) | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 2,234 | 13,083 | - | - | Non-Qualified Stock Option (right to buy) | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.58 per share. | 03 Sep 2025 | 2,234 | 18,171 (0%) | 0% | 37.6 | 83,954 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 03 Sep 2025 | 928 | 15,937 (0%) | 0% | 32.6 | 30,253 | Common Stock |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 02 Sep 2025 | 10,750 | 75,594 (0%) | 0% | 50.4 | 542,015 | Common Stock |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 51.49 per share. | 02 Sep 2025 | 9,250 | 66,344 (0%) | 0% | 51.5 | 476,283 | Common Stock |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 60.14 per share. | 02 Sep 2025 | 11,200 | 108,835 (0%) | 0% | 60.1 | 673,549 | Common Stock |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 55.04 per share. | 02 Sep 2025 | 11,200 | 125,635 (0%) | 0% | 55.0 | 616,432 | Common Stock |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 55.04 per share. | 02 Sep 2025 | 11,200 | 125,635 (0%) | 0% | 55.0 | 616,432 | Common Stock |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 57.53 per share. | 02 Sep 2025 | 5,600 | 120,035 (0%) | 0% | 57.5 | 322,174 | Common Stock |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 60.14 per share. | 02 Sep 2025 | 11,200 | 108,835 (0%) | 0% | 60.1 | 673,549 | Common Stock |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 57.53 per share. | 02 Sep 2025 | 5,600 | 120,035 (0%) | 0% | 57.5 | 322,174 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 50.37 per share. | 02 Sep 2025 | 10,000 | 79,657 (0%) | 0% | 50.4 | 503,671 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 02 Sep 2025 | 46,800 | 135,479 (0%) | 0% | 53.8 | 2,516,436 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 49.14 per share. | 02 Sep 2025 | 5,000 | 88,679 (0%) | 0% | 49.1 | 245,700 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 46,800 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 61.50 per share. | 02 Sep 2025 | 12,891 | 88,679 (0%) | 0% | 61.5 | 792,797 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 60.62 per share. | 02 Sep 2025 | 33,909 | 101,570 (0%) | 0% | 60.6 | 2,055,564 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 14,000 | 8,942 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 49,800 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 13,050 | 4,467 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 13,050 | 17,517 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 02 Sep 2025 | 49,800 | 57,130 (0%) | 0% | 53.8 | 2,677,746 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 61.42 per share. | 02 Sep 2025 | 11,375 | 7,330 (0%) | 0% | 61.4 | 698,653 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 02 Sep 2025 | 13,050 | 18,705 (0%) | 0% | 32.6 | 425,430 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 60.89 per share. | 02 Sep 2025 | 65,475 | 5,655 (0%) | 0% | 60.9 | 3,986,773 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.58 per share. | 02 Sep 2025 | 14,000 | 71,130 (0%) | 0% | 37.6 | 526,120 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 54.51 per share. | 02 Sep 2025 | 13,050 | 57,130 (0%) | 0% | 54.5 | 711,418 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 02 Sep 2025 | 13,050 | 70,180 (0%) | 0% | 32.6 | 425,430 | Common Stock |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 53.68 per share. | 02 Sep 2025 | 1,130 | 37,302 (0%) | 0% | 53.7 | 60,662 | Common Stock |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 49.22 per share. | 02 Sep 2025 | 10,000 | 38,432 (0%) | 0% | 49.2 | 492,200 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Other type of transaction at price $ 27.71 per share. | 29 Aug 2025 | 165 | 89,657 (0%) | 0% | 27.7 | 4,572 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Other type of transaction at price $ 27.71 per share. | 29 Aug 2025 | 213 | 93,679 (0%) | 0% | 27.7 | 5,902 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Other type of transaction at price $ 27.71 per share. | 29 Aug 2025 | 189 | 180,009 (0%) | 0% | 27.7 | 5,237 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Other type of transaction at price $ 27.71 per share. | 29 Aug 2025 | 331 | 57,130 (0%) | 0% | 27.7 | 9,172 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Other type of transaction at price $ 27.71 per share. | 29 Aug 2025 | 166 | 56,826 (0%) | 0% | 27.7 | 4,600 | Common Stock |
| Allene M. Diaz | Director | Sale of securities on an exchange or to another person at price $ 42.53 per share. | 22 Aug 2025 | 1,427 | 18,368 (0%) | 0% | 42.5 | 60,687 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 18 Aug 2025 | 10,000 | 103,466 (0%) | 0% | 32.6 | 326,000 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Aug 2025 | 10,000 | 18,869 | - | - | Non-Qualified Stock Option (right to buy) | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 43.98 per share. | 18 Aug 2025 | 10,000 | 93,466 (0%) | 0% | 44.0 | 439,776 | Common Stock |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 41.87 per share. | 06 Aug 2025 | 4,600 | 86,744 (0%) | 0% | 41.9 | 192,595 | Common Stock |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 42.63 per share. | 06 Aug 2025 | 400 | 86,344 (0%) | 0% | 42.6 | 17,051 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 42.86 per share. | 05 Aug 2025 | 10,000 | 89,492 (0%) | 0% | 42.9 | 428,593 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 42.80 per share. | 04 Aug 2025 | 9,549 | 51,507 (0%) | 0% | 42.8 | 408,701 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 30 Jul 2025 | 2,432 | 182,252 (0%) | 0% | 32.6 | 79,283 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2025 | 2,432 | 99,057 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 30 Jul 2025 | 2,432 | 179,820 (0%) | 0% | 45 | 109,440 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 91,344 (0%) | 0% | 0 | Common Stock | |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 5,220 | - | - | Restricted Stock Unit | |
| Joseph H. Wender | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 136,835 (0%) | 0% | 0 | Common Stock | |
| Joseph H. Wender | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 1,141 | - | - | Restricted Stock Unit | |
| Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 36,330 (0%) | 0% | 0 | Common Stock | |
| Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 5,220 | - | - | Restricted Stock Unit | |
| Joan E. Herman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 46,086 (0%) | 0% | 0 | Common Stock | |
| Joan E. Herman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 5,220 | - | - | Restricted Stock Unit | |
| Spencer R. Berthelsen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 156,013 (0%) | 0% | 0 | Common Stock | |
| Spencer R. Berthelsen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 5,220 | - | - | Restricted Stock Unit | |
| Michael Hayden | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 54,298 (0%) | 0% | 0 | Common Stock | |
| Michael Hayden | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 9,897 | - | - | Restricted Stock Unit | |
| Michael J. Yang | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 9,080 | - | - | Restricted Stock Unit | |
| Michael J. Yang | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 6,010 (0%) | 0% | 0 | Common Stock | |
| Allene M. Diaz | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 5,220 | - | - | Restricted Stock Unit | |
| Allene M. Diaz | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 19,795 (0%) | 0% | 0 | Common Stock | |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 41.74 per share. | 11 Jul 2025 | 1,160 | 179,820 (0%) | 0% | 41.7 | 48,416 | Common Stock |
| B. Lynne Parshall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 11,518 | 11,518 | - | - | Non-Qualified Stock Option (right to buy) | |
| B. Lynne Parshall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 5,220 | 9,299 | - | - | Restricted Stock Unit | |
| Joseph H. Wender | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 11,518 | 11,518 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph H. Wender | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 5,220 | 9,299 | - | - | Restricted Stock Unit | |
| Joseph Klein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 5,220 | 13,976 | - | - | Restricted Stock Unit | |
| Joseph Klein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 11,518 | 11,518 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Loscalzo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 5,220 | 9,299 | - | - | Restricted Stock Unit | |
| Joseph Loscalzo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 11,518 | 11,518 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joan E. Herman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 5,220 | 9,299 | - | - | Restricted Stock Unit | |
| Joan E. Herman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 11,518 | 11,518 | - | - | Non-Qualified Stock Option (right to buy) | |
| Spencer R. Berthelsen | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 11,518 | 11,518 | - | - | Non-Qualified Stock Option (right to buy) | |
| Spencer R. Berthelsen | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 5,220 | 9,299 | - | - | Restricted Stock Unit | |
| Michael Hayden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 5,220 | 13,976 | - | - | Restricted Stock Unit | |
| Michael Hayden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 11,518 | 11,518 | - | - | Non-Qualified Stock Option (right to buy) | |
| Michael J. Yang | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 5,220 | 13,159 | - | - | Restricted Stock Unit | |
| Michael J. Yang | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 11,518 | 11,518 | - | - | Non-Qualified Stock Option (right to buy) | |
| Allene M. Diaz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 5,220 | 9,299 | - | - | Restricted Stock Unit | |
| Allene M. Diaz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 11,518 | 11,518 | - | - | Non-Qualified Stock Option (right to buy) | |
| Michael Hayden | Director | Purchase of securities on an exchange or from another person at price $ 31.86 per share. | 01 May 2025 | 15,000 | 50,219 (0%) | 0% | 31.9 | 477,900 | Common Stock |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Sale of securities on an exchange or to another person at price $ 28.36 per share. | 15 Apr 2025 | 3,016 | 11,199 (0%) | 0% | 28.4 | 85,534 | Common Stock |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2025 | 12,226 | 14,215 (0%) | 0% | 0 | Common Stock | |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2025 | 12,226 | 36,677 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2025 | 10,837 | 66,511 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 28.40 per share. | 15 Apr 2025 | 3,928 | 31,926 (0%) | 0% | 28.4 | 111,555 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2025 | 10,837 | 35,854 (0%) | 0% | 0 | Common Stock | |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2025 | 1,875 | 61,215 | - | - | Restricted Stock Unit | |
| Brian Birchler | EVP, Corp and Development Ops | Sale of securities on an exchange or to another person at price $ 28.37 per share. | 15 Apr 2025 | 680 | 56,660 (0%) | 0% | 28.4 | 19,292 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2025 | 1,875 | 57,340 (0%) | 0% | 0 | Common Stock | |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 32.32 per share. | 11 Mar 2025 | 140 | 180,980 (0%) | 0% | 32.3 | 4,525 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Other type of transaction at price $ 28.21 per share. | 28 Feb 2025 | 415 | 99,492 (0%) | 0% | 28.2 | 11,708 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Other type of transaction at price $ 28.21 per share. | 28 Feb 2025 | 320 | 93,466 (0%) | 0% | 28.2 | 9,028 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Other type of transaction at price $ 28.21 per share. | 28 Feb 2025 | 437 | 181,120 (0%) | 0% | 28.2 | 12,328 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Other type of transaction at price $ 28.21 per share. | 28 Feb 2025 | 554 | 56,799 (0%) | 0% | 28.2 | 15,629 | Common Stock |
| Eric E. Swayze | EVP Research | Other type of transaction at price $ 28.21 per share. | 28 Feb 2025 | 415 | 48,432 (0%) | 0% | 28.2 | 11,708 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Other type of transaction at price $ 28.21 per share. | 28 Feb 2025 | 414 | 55,465 (0%) | 0% | 28.2 | 11,680 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 32.35 per share. | 20 Feb 2025 | 1,207 | 56,245 (0%) | 0% | 32.3 | 39,046 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 31.65 per share. | 04 Feb 2025 | 38,843 | 180,683 (0%) | 0% | 31.7 | 1,229,463 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 31.62 per share. | 04 Feb 2025 | 6,165 | 57,452 (0%) | 0% | 31.6 | 194,939 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Sale of securities on an exchange or to another person at price $ 32.44 per share. | 30 Jan 2025 | 1,523 | 110,500 (0%) | 0% | 32.4 | 49,404 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2025 | 4,138 | 112,023 (0%) | 0% | 0 | Common Stock | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 32.49 per share. | 30 Jan 2025 | 1,406 | 63,617 (0%) | 0% | 32.5 | 45,685 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2025 | 3,820 | 65,023 (0%) | 0% | 0 | Common Stock | |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 32.31 per share. | 30 Jan 2025 | 1,367 | 48,017 (0%) | 0% | 32.3 | 44,162 | Common Stock |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2025 | 3,714 | 49,384 (0%) | 0% | 0 | Common Stock | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 32.20 per share. | 30 Jan 2025 | 1,484 | 61,056 (0%) | 0% | 32.2 | 47,780 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2025 | 4,032 | 62,540 (0%) | 0% | 0 | Common Stock | |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 32.40 per share. | 30 Jan 2025 | 1,406 | 99,077 (0%) | 0% | 32.4 | 45,561 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2025 | 3,820 | 100,483 (0%) | 0% | 0 | Common Stock | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 32.46 per share. | 30 Jan 2025 | 1,327 | 93,146 (0%) | 0% | 32.5 | 43,079 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2025 | 3,607 | 94,473 (0%) | 0% | 0 | Common Stock | |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2025 | 25,372 | 232,768 (0%) | 0% | 0 | Common Stock | |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 32.45 per share. | 30 Jan 2025 | 13,242 | 219,526 (0%) | 0% | 32.4 | 429,655 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 18,901 | 60,724 | - | - | Restricted Stock Unit | |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 18,901 | 103,735 (0%) | 0% | 0 | Common Stock | |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 32.86 per share. | 15 Jan 2025 | 7,072 | 96,663 (0%) | 0% | 32.9 | 232,407 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 22,000 | 64,801 | - | - | Performance Restricted Stock Units | |
| Richard S. Geary | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 33,000 | 79,625 | - | - | Restricted Stock Unit | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 18,011 | 97,618 (0%) | 0% | 0 | Common Stock | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 18,011 | 38,489 | - | - | Restricted Stock Unit | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 33,000 | 56,500 | - | - | Restricted Stock Unit | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 22,000 | 63,482 | - | - | Performance Restricted Stock Units | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 32.90 per share. | 15 Jan 2025 | 6,752 | 90,866 (0%) | 0% | 32.9 | 222,114 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 73,448 | 240,841 (0%) | 0% | 0 | Common Stock | |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 73,448 | 252,159 | - | - | Restricted Stock Unit | |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 129,395 | 325,607 | - | - | Restricted Stock Unit | |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 169,950 | 630,201 | - | - | Performance Restricted Stock Units | |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 32.63 per share. | 15 Jan 2025 | 33,445 | 207,396 (0%) | 0% | 32.6 | 1,091,444 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 23,887 | 84,669 | - | - | Restricted Stock Unit | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 23,887 | 116,755 (0%) | 0% | 0 | Common Stock | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Sale of securities on an exchange or to another person at price $ 32.81 per share. | 15 Jan 2025 | 8,870 | 107,885 (0%) | 0% | 32.8 | 290,989 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 31,000 | 86,635 | - | - | Performance Restricted Stock Units | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 46,500 | 108,556 | - | - | Restricted Stock Unit | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 33,000 | 80,414 | - | - | Restricted Stock Unit | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 19,690 | 68,563 (0%) | 0% | 0 | Common Stock | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 32.83 per share. | 15 Jan 2025 | 7,360 | 61,203 (0%) | 0% | 32.8 | 241,629 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 22,000 | 64,801 | - | - | Performance Restricted Stock Units | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 19,690 | 60,724 | - | - | Restricted Stock Unit | |
| Michael J. Yang | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 1,931 | 7,939 | - | - | Restricted Stock Unit | |
| Michael J. Yang | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 1,931 | 1,931 (0%) | 0% | 0 | Common Stock | |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 18,700 | 18,700 | - | - | Performance Restricted Stock Units | |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 28,050 | 28,050 | - | - | Restricted Stock Unit | |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 49 | 622 | - | - | Restricted Stock Unit | |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 19,111 | 52,824 (0%) | 0% | 0 | Common Stock | |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 32.84 per share. | 15 Jan 2025 | 7,154 | 45,670 (0%) | 0% | 32.8 | 234,959 | Common Stock |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 49 | 206 (0%) | 0% | 0 | Common Stock | |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 32.68 per share. | 15 Jan 2025 | 22 | 184 (0%) | 0% | 32.7 | 719 | Common Stock |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 22,000 | 64,482 | - | - | Performance Restricted Stock Units | |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 33,000 | 79,728 | - | - | Restricted Stock Unit | |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 19,111 | 60,617 | - | - | Restricted Stock Unit | |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 245 | 671 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 32.70 per share. | 15 Jan 2025 | 3,401 | 25,017 (0%) | 0% | 32.7 | 111,213 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 8,787 | 28,418 (0%) | 0% | 0 | Common Stock | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 2,460 | 8,324 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 3,750 | 10,784 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 8,787 | 77,348 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 33,000 | 86,135 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 22,000 | 51,290 | - | - | Performance Restricted Stock Units | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 32.70 per share. | 15 Jan 2025 | 1,029 | 3,071 (0%) | 0% | 32.7 | 33,648 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 2,460 | 4,100 (0%) | 0% | 0 | Common Stock | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 17,372 | 65,031 (0%) | 0% | 0 | Common Stock | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 32.79 per share. | 15 Jan 2025 | 6,523 | 58,508 (0%) | 0% | 32.8 | 213,889 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 22,000 | 65,437 | - | - | Performance Restricted Stock Units | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 33,000 | 78,308 | - | - | Restricted Stock Unit | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 17,372 | 60,936 | - | - | Restricted Stock Unit | |
| Brian Birchler | EVP, Corp and Development Ops | Sale of securities on an exchange or to another person at price $ 32.70 per share. | 15 Jan 2025 | 5,400 | 55,051 (0%) | 0% | 32.7 | 176,580 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 14,283 | 60,451 (0%) | 0% | 0 | Common Stock | |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 14,283 | 63,090 | - | - | Restricted Stock Unit | |
| Brian Birchler | EVP, Corp and Development Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 33,000 | 77,373 | - | - | Restricted Stock Unit | |
| Brian Birchler | EVP, Corp and Development Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 22,000 | 53,338 | - | - | Performance Restricted Stock Units | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 22,000 | 22,000 | - | - | Performance Restricted Stock Units | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 12,295 | 63,226 | - | - | Restricted Stock Unit | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 12,295 | 20,204 (0%) | 0% | 0 | Common Stock | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Sale of securities on an exchange or to another person at price $ 32.78 per share. | 15 Jan 2025 | 4,267 | 15,937 (0%) | 0% | 32.8 | 139,855 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 33,000 | 75,521 | - | - | Restricted Stock Unit | |
| Richard S. Geary | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 22,000 | 22,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 22,000 | 22,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 86,263 | 86,263 | - | - | Non-Qualified Stock Option (right to buy) | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 31,000 | 31,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 22,000 | 22,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 18,700 | 18,700 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 163 | 163 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 22,000 | 22,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 22,000 | 22,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 2,500 | 2,500 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 22,000 | 22,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brian Birchler | EVP, Corp and Development Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 22,000 | 22,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 22,000 | 22,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Michael Hayden | Director | Purchase of securities on an exchange or from another person at price $ 36.23 per share. | 23 Dec 2024 | 2,500 | 35,219 (0%) | 0% | 36.2 | 90,583 | Common Stock |
| Michael Hayden | Director | Purchase of securities on an exchange or from another person at price $ 36.20 per share. | 23 Dec 2024 | 2,500 | 32,719 (0%) | 0% | 36.2 | 90,496 | Common Stock |
| Joseph Loscalzo | Director | Sale of securities on an exchange or to another person at price $ 37.86 per share. | 12 Nov 2024 | 13,508 | 32,251 (0%) | 0% | 37.9 | 511,426 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 38.05 per share. | 12 Nov 2024 | 6,630 | 167,393 (0%) | 0% | 38.1 | 252,294 | Common Stock |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 37.92 per share. | 12 Nov 2024 | 1,194 | 33,713 (0%) | 0% | 37.9 | 45,278 | Common Stock |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 38.32 per share. | 15 Oct 2024 | 53 | 157 (0%) | 0% | 38.3 | 2,031 | Common Stock |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2024 | 125 | 210 (0%) | 0% | 0 | Common Stock | |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2024 | 125 | 426 | - | - | Restricted Stock Unit | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | 15 Oct 2024 | 11,280 | 42,521 | - | - | Restricted Stock Unit | ||
| Shannon L. Devers | EVP, Chief Human Resourses Ofc | 29 Sep 2024 | 15,040 | 15,040 | - | - | Non-Qualified Stock Option (right to buy) | ||
| Richard S. Geary | EVP, Chief Development Officer | Other type of transaction at price $ 38.64 per share. | 30 Aug 2024 | 11 | 84,834 (0%) | 0% | 38.6 | 425 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Other type of transaction at price $ 38.64 per share. | 30 Aug 2024 | 177 | 79,607 (0%) | 0% | 38.6 | 6,839 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Other type of transaction at price $ 38.64 per share. | 30 Aug 2024 | 140 | 174,023 (0%) | 0% | 38.6 | 5,410 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Other type of transaction at price $ 38.64 per share. | 30 Aug 2024 | 246 | 48,873 (0%) | 0% | 38.6 | 9,506 | Common Stock |
| Eric E. Swayze | EVP Research | Other type of transaction at price $ 38.64 per share. | 30 Aug 2024 | 11 | 34,907 (0%) | 0% | 38.6 | 425 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Other type of transaction at price $ 38.67 per share. | 30 Aug 2024 | 12 | 46,168 (0%) | 0% | 38.7 | 464 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 49.63 per share. | 28 Aug 2024 | 331 | 84,823 (0%) | 0% | 49.6 | 16,428 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 49.16 per share. | 28 Aug 2024 | 320 | 85,154 (0%) | 0% | 49.2 | 15,731 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 48.00 per share. | 05 Aug 2024 | 2,430 | 85,508 (0%) | 0% | 48 | 116,640 | Common Stock |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.42 per share. | 16 Jul 2024 | 12,000 | 12,000 (0%) | 0% | 24.4 | 293,040 | Common Stock |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jul 2024 | 12,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 50.00 per share. | 16 Jul 2024 | 12,000 | 0 (0%) | 0% | 50 | 600,000 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 4,079 | - | - | Restricted Stock Unit | |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 87,265 (0%) | 0% | 0 | Common Stock | |
| Joseph H. Wender | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 4,079 | - | - | Restricted Stock Unit | |
| Joseph H. Wender | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 132,756 (0%) | 0% | 0 | Common Stock | |
| Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 45,759 (0%) | 0% | 0 | Common Stock | |
| Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 4,079 | - | - | Restricted Stock Unit | |
| Joan E. Herman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 4,079 | - | - | Restricted Stock Unit | |
| Joan E. Herman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 42,007 (0%) | 0% | 0 | Common Stock | |
| Spencer R. Berthelsen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 4,079 | - | - | Restricted Stock Unit | |
| Spencer R. Berthelsen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 151,934 (0%) | 0% | 0 | Common Stock | |
| Allene M. Diaz | Director | Sale of securities on an exchange or to another person at price $ 48.94 per share. | 15 Jul 2024 | 900 | 16,453 (0%) | 0% | 48.9 | 44,044 | Common Stock |
| Allene M. Diaz | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 4,079 | - | - | Restricted Stock Unit | |
| Allene M. Diaz | Director | Sale of securities on an exchange or to another person at price $ 50.17 per share. | 15 Jul 2024 | 737 | 15,716 (0%) | 0% | 50.2 | 36,975 | Common Stock |
| Allene M. Diaz | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 17,353 (0%) | 0% | 0 | Common Stock | |
| B. Lynne Parshall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 10,111 | 10,111 | - | - | Non-Qualified Stock Option (right to buy) | |
| B. Lynne Parshall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 4,079 | 8,756 | - | - | Restricted Stock Unit | |
| Joseph H. Wender | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 4,079 | 8,756 | - | - | Restricted Stock Unit | |
| Joseph H. Wender | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 10,111 | 10,111 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 10,111 | 10,111 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 4,079 | 8,756 | - | - | Restricted Stock Unit | |
| Joseph Loscalzo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 10,111 | 10,111 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Loscalzo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 4,079 | 8,756 | - | - | Restricted Stock Unit | |
| Joan E. Herman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 10,111 | 10,111 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joan E. Herman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 4,079 | 8,756 | - | - | Restricted Stock Unit | |
| Spencer R. Berthelsen | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 4,079 | 8,756 | - | - | Restricted Stock Unit | |
| Spencer R. Berthelsen | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 10,111 | 10,111 | - | - | Non-Qualified Stock Option (right to buy) | |
| Michael Hayden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 10,111 | 10,111 | - | - | Non-Qualified Stock Option (right to buy) | |
| Michael Hayden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 4,079 | 8,756 | - | - | Restricted Stock Unit | |
| Michael J. Yang | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 4,079 | 9,870 | - | - | Restricted Stock Unit | |
| Allene M. Diaz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 10,111 | 10,111 | - | - | Non-Qualified Stock Option (right to buy) | |
| Allene M. Diaz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 4,079 | 8,756 | - | - | Restricted Stock Unit | |
| Spencer R. Berthelsen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 35.53 per share. | 17 Jun 2024 | 16,000 | 163,257 (0%) | 0% | 35.5 | 568,480 | Common Stock |
| Spencer R. Berthelsen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jun 2024 | 16,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Spencer R. Berthelsen | Director | Sale of securities on an exchange or to another person at price $ 40.29 per share. | 17 Jun 2024 | 16,000 | 147,257 (0%) | 0% | 40.3 | 644,640 | Common Stock |
| Joseph H. Wender | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 35.53 per share. | 09 May 2024 | 16,000 | 128,079 (0%) | 0% | 35.5 | 568,480 | Common Stock |
| Joseph H. Wender | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 May 2024 | 16,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 42.57 per share. | 03 May 2024 | 1,318 | 4,682 (0%) | 0% | 42.6 | 56,110 | Common Stock |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 42.90 per share. | 03 May 2024 | 930 | 0 (0%) | 0% | 42.9 | 39,893 | Common Stock |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 42.55 per share. | 03 May 2024 | 1,070 | 930 (0%) | 0% | 42.5 | 45,526 | Common Stock |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 42.98 per share. | 03 May 2024 | 731 | 2,000 (0%) | 0% | 43.0 | 31,416 | Common Stock |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 42.59 per share. | 03 May 2024 | 1,269 | 2,731 (0%) | 0% | 42.6 | 54,044 | Common Stock |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 42.94 per share. | 03 May 2024 | 682 | 4,000 (0%) | 0% | 42.9 | 29,288 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2024 | 10,838 | 53,135 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 41.60 per share. | 15 Apr 2024 | 4,006 | 19,631 (0%) | 0% | 41.6 | 166,641 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2024 | 10,838 | 23,637 (0%) | 0% | 0 | Common Stock | |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2024 | 1,875 | 44,373 | - | - | Restricted Stock Unit | |
| Brian Birchler | EVP, Corp and Development Ops | Sale of securities on an exchange or to another person at price $ 41.66 per share. | 15 Apr 2024 | 905 | 46,156 (0%) | 0% | 41.7 | 37,698 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2024 | 1,875 | 47,061 (0%) | 0% | 0 | Common Stock | |
| Richard S. Geary | Officer Level 14 | Other type of transaction at price $ 34.43 per share. | 29 Feb 2024 | 604 | 87,938 (0%) | 0% | 34.4 | 20,793 | Common Stock |
| C. Frank Bennett | Officer Level 14 | Other type of transaction at price $ 34.43 per share. | 29 Feb 2024 | 383 | 79,462 (0%) | 0% | 34.4 | 13,185 | Common Stock |
| Brett P. Monia | Director, CEO Level 15 | Other type of transaction at price $ 34.43 per share. | 29 Feb 2024 | 538 | 174,289 (0%) | 0% | 34.4 | 18,521 | Common Stock |
| Eric E. Swayze | Officer Level 14 | Other type of transaction at price $ 34.42 per share. | 29 Feb 2024 | 605 | 34,929 (0%) | 0% | 34.4 | 20,827 | Common Stock |
| Brian Birchler | Vice President Level 14 | Other type of transaction at price $ 34.43 per share. | 29 Feb 2024 | 604 | 45,186 (0%) | 0% | 34.4 | 20,793 | Common Stock |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2024 | 65,203 | 65,203 | - | - | Non-Qualified Stock Option (right to buy) | |
| Monia P. Brett | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 44.49 per share. | 16 Feb 2024 | 387 | 173,751 (0%) | 0% | 44.5 | 17,219 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 50.04 per share. | 02 Feb 2024 | 1,995 | 87,300 (0%) | 0% | 50.0 | 99,836 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 49.52 per share. | 02 Feb 2024 | 1,885 | 79,047 (0%) | 0% | 49.5 | 93,337 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 49.37 per share. | 02 Feb 2024 | 23,907 | 173,732 (0%) | 0% | 49.4 | 1,180,348 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 49.37 per share. | 02 Feb 2024 | 23,907 | 173,732 (0%) | 0% | 49.4 | 1,180,348 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Sale of securities on an exchange or to another person at price $ 49.54 per share. | 02 Feb 2024 | 2,162 | 92,868 (0%) | 0% | 49.5 | 107,105 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 49.67 per share. | 02 Feb 2024 | 1,995 | 48,627 (0%) | 0% | 49.7 | 99,099 | Common Stock |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 49.56 per share. | 02 Feb 2024 | 1,940 | 34,291 (0%) | 0% | 49.6 | 96,149 | Common Stock |
| Onaiza Cadoret-Manier | EVP,Chf GL Pdt Str & Oper Ofc | Sale of securities on an exchange or to another person at price $ 49.60 per share. | 02 Feb 2024 | 2,162 | 35,788 (0%) | 0% | 49.6 | 107,240 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 49.59 per share. | 02 Feb 2024 | 2,106 | 47,659 (0%) | 0% | 49.6 | 104,437 | Common Stock |
| Onaiza Cadoret-Manier | EVP, Chf GL Pdt Str & Oper Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 4,140 | 37,950 (0%) | 0% | 0 | Common Stock | |
| Schneider Eugene | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 49.59 per share. | 01 Feb 2024 | 2,071 | 49,812 (0%) | 0% | 49.6 | 102,701 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 20,416 | 197,639 (0%) | 0% | 0 | Common Stock | |
| S. Geary Richard | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 3,820 | 89,295 (0%) | 0% | 0 | Common Stock | |
| L. Elizabeth Hougen | EVP, Finance & CFO | Sale of securities on an exchange or to another person at price $ 49.54 per share. | 01 Feb 2024 | 2,125 | 92,905 (0%) | 0% | 49.5 | 105,272 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 3,609 | 80,932 (0%) | 0% | 0 | Common Stock | |
| C. Bennett Frank | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 49.52 per share. | 01 Feb 2024 | 1,853 | 79,079 (0%) | 0% | 49.5 | 91,752 | Common Stock |
| Richard Geary S. | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 50.04 per share. | 01 Feb 2024 | 1,961 | 87,334 (0%) | 0% | 50.0 | 98,135 | Common Stock |
| Onaiza Cadoret-Manier | EVP, Chf GL Pdt Str & Oper Ofc | Sale of securities on an exchange or to another person at price $ 49.60 per share. | 01 Feb 2024 | 2,125 | 35,825 (0%) | 0% | 49.6 | 105,404 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 4,033 | 51,883 (0%) | 0% | 0 | Common Stock | |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 49.37 per share. | 01 Feb 2024 | 23,501 | 174,138 (0%) | 0% | 49.4 | 1,160,303 | Common Stock |
| O'Neil R. Patrick | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 3,820 | 50,622 (0%) | 0% | 0 | Common Stock | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 4,140 | 95,030 (0%) | 0% | 0 | Common Stock | |
| R. Patrick O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 49.67 per share. | 01 Feb 2024 | 1,961 | 48,661 (0%) | 0% | 49.7 | 97,410 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 25,372 | 177,223 (0%) | 0% | 0 | Common Stock | |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 52.00 per share. | 31 Jan 2024 | 10,773 | 32,516 (0%) | 0% | 52 | 560,196 | Common Stock |
| Swayze E. Eric | EVP Research | Sale of securities on an exchange or to another person at price $ 49.56 per share. | 31 Jan 2024 | 1,907 | 34,324 (0%) | 0% | 49.6 | 94,513 | Common Stock |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 3,715 | 36,231 (0%) | 0% | 0 | Common Stock | |
| R. O'Neil Patrick | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 51.75 per share. | 25 Jan 2024 | 6,450 | 46,802 (0%) | 0% | 51.8 | 333,788 | Common Stock |
| P. Monia Brett | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 51.75 per share. | 25 Jan 2024 | 2,285 | 151,851 (0%) | 0% | 51.8 | 118,249 | Common Stock |
| P. Monia Brett | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 32,059 | 154,136 (0%) | 0% | 50.4 | 1,616,319 | Common Stock |
| E. Swayze Eric | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 17,069 | 46,728 | - | - | Restricted Stock Unit | |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 21 | 551 | - | - | Restricted Stock Unit | |
| S. Richard Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 19,852 | 92,813 (0%) | 0% | 0 | Common Stock | |
| Elizabeth Hougen L. | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 22,487 | 99,573 (0%) | 0% | 0 | Common Stock | |
| E. Eric Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 50.44 per share. | 16 Jan 2024 | 9 | 85 (0%) | 0% | 50.4 | 454 | Common Stock |
| T. Joseph Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 564 | 1,640 (0%) | 0% | 50.4 | 28,435 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 1,353 | 2,204 (0%) | 0% | 0 | Common Stock | |
| Schneider Eugene | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 15,162 | 53,332 (0%) | 0% | 0 | Common Stock | |
| C. Bennett Frank | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 18,314 | 23,500 | - | - | Restricted Stock Unit | |
| T. Joseph Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 1,460 | 12,799 (0%) | 0% | 50.4 | 73,609 | Common Stock |
| Onaiza Cadoret-Manier | EVP, Chf GL Pdt Str & Oper Ofc | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 5,564 | 33,810 (0%) | 0% | 50.4 | 280,520 | Common Stock |
| Baroldi T. Joseph | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 3,688 | 14,259 (0%) | 0% | 0 | Common Stock | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 5,482 | 47,850 (0%) | 0% | 50.4 | 276,386 | Common Stock |
| C. Bennett Frank | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 18,314 | 84,068 (0%) | 0% | 0 | Common Stock | |
| S. Geary Richard | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 19,852 | 46,625 | - | - | Restricted Stock Unit | |
| C. Bennett Frank | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 6,745 | 77,323 (0%) | 0% | 50.4 | 340,063 | Common Stock |
| Birchler Brian | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 12,080 | 46,248 | - | - | Restricted Stock Unit | |
| Onaiza Cadoret-Manier | EVP, Chf GL Pdt Str & Oper Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 15,062 | 39,374 (0%) | 0% | 0 | Common Stock | |
| R. Patrick O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 20,641 | 47,414 | - | - | Restricted Stock Unit | |
| L. Hougen Elizabeth | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 22,487 | 62,056 | - | - | Restricted Stock Unit | |
| Baroldi Joseph T. | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 3,688 | 63,973 | - | - | Restricted Stock Unit | |
| R. O'Neil Patrick | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 7,744 | 53,252 (0%) | 0% | 50.4 | 390,429 | Common Stock |
| Richard Geary S. | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 7,338 | 85,475 (0%) | 0% | 50.4 | 369,960 | Common Stock |
| Swayze Eric E. | EVP Research | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 6,296 | 43,289 (0%) | 0% | 50.4 | 317,425 | Common Stock |
| Birchler Brian | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 12,080 | 49,079 (0%) | 0% | 0 | Common Stock | |
| Patrick O'Neil R. | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 20,641 | 60,996 (0%) | 0% | 0 | Common Stock | |
| Schneider Eugene | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 15,162 | 45,308 | - | - | Restricted Stock Unit | |
| L. Hougen Elizabeth | EVP, Finance & CFO | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 8,683 | 90,890 (0%) | 0% | 50.4 | 437,771 | Common Stock |
| Monia P. Brett | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 68,084 | 186,195 (0%) | 0% | 0 | Common Stock | |
| Swayze Eric E. | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 21 | 94 (0%) | 0% | 0 | Common Stock | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 1,353 | 7,034 | - | - | Restricted Stock Unit | |
| Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 15,062 | 66,997 | - | - | Restricted Stock Unit | |
| Swayze Eric E. | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 17,069 | 49,585 (0%) | 0% | 0 | Common Stock | |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 68,084 | 196,212 | - | - | Restricted Stock Unit | |
| Brian Birchler | EVP, Corp and Development Ops | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 4,497 | 44,582 (0%) | 0% | 50.4 | 226,725 | Common Stock |
| Elizabeth Hougen L. | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 27,000 | 55,635 | - | - | Performance Restricted Stock Units | |
| Onaiza Cadoret-Manier | EVP, Chf GL Pdt Str & Oper Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 27,000 | 55,635 | - | - | Performance Restricted Stock Units | |
| Brian Birchler | EVP, Corp and Development Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 17,000 | 31,338 | - | - | Performance Restricted Stock Units | |
| Joseph Baroldi T. | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 2,625 | 8,387 | - | - | Restricted Stock Unit | |
| E. Swayze Eric | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 17,000 | 42,482 | - | - | Performance Restricted Stock Units | |
| S. Geary Richard | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 20,400 | 66,477 | - | - | Restricted Stock Unit | |
| Baroldi T. Joseph | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 17,000 | 29,290 | - | - | Performance Restricted Stock Units | |
| Monia P. Brett | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 143,550 | 460,251 | - | - | Performance Restricted Stock Units | |
| Geary S. Richard | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 17,000 | 42,801 | - | - | Performance Restricted Stock Units | |
| Joseph Baroldi T. | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 20,400 | 67,661 | - | - | Restricted Stock Unit | |
| R. Patrick O'Neil | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 17,000 | 42,801 | - | - | Performance Restricted Stock Units | |
| Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 32,400 | 82,059 | - | - | Restricted Stock Unit | |
| L. Hougen Elizabeth | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 32,400 | 84,543 | - | - | Restricted Stock Unit | |
| Bennett C. Frank | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 20,400 | 41,814 | - | - | Restricted Stock Unit | |
| E. Swayze Eric | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 20,400 | 63,797 | - | - | Restricted Stock Unit | |
| O'Neil R. Patrick | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 20,400 | 68,055 | - | - | Restricted Stock Unit | |
| Swayze E. Eric | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 116 | 572 | - | - | Restricted Stock Unit | |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 87,435 | 264,296 | - | - | Restricted Stock Unit | |
| Michael Yang J. | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 5,791 | 5,791 | - | - | Restricted Stock Unit | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 17,000 | 41,482 | - | - | Performance Restricted Stock Units | |
| Baroldi T. Joseph | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 1,800 | 5,762 | - | - | Restricted Stock Unit | |
| Brian Birchler | EVP, Corp and Development Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 20,400 | 58,328 | - | - | Restricted Stock Unit | |
| Schneider Eugene | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2024 | 17,000 | 43,437 | - | - | Performance Restricted Stock Units | |
| Schneider Eugene | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 12 Jan 2024 | 8,000 | 46,170 (0%) | 0% | 32.6 | 260,800 | Common Stock |