Insider Trading disclosures for Ionis Pharma Inc

The latest disclosure was made by C. Frank Bennett in Ionis Pharma Inc where a trade of 110 Common Stock done at an average price of $51.3 was reported to US exchanges on Aug. 31, 2026.

Insider trading is the trading of a company’s securities by individuals with access to confidential or material non-public information about the company. A company is required to report trading by corporate officers, directors, or other company members with significant access to privileged information to the Securities and Exchange Commission (SEC).

Client Name	Client Category	Action	Reported to Exchange	Quantity	Post Transaction Holding	Traded %	Avg. Price	Value	Security Type
C. Frank Bennett	EVP, Chief Scientific Officer	Other type of transaction at price $ 51.31 per share.	31 Aug 2026	110	60,128 (0%)	0%	51.3	5,644	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Other type of transaction at price $ 51.31 per share.	31 Aug 2026	98	242,760 (0%)	0%	51.3	5,028	Common Stock
Patrick R. O'Neil	EVP CLO & General Counsel	Other type of transaction at price $ 51.30 per share.	31 Aug 2026	63	59,205 (0%)	0%	51.3	3,232	Common Stock
Brian Birchler	EVP, Corp and Development Ops	Other type of transaction at price $ 51.31 per share.	31 Aug 2026	58	102,883 (0%)	0%	51.3	2,976	Common Stock
Michael Hayden	Director	Purchase of securities on an exchange or from another person at price $ 51.60 per share.	30 Jul 2026	5,000	24,000 (0%)	0%	51.6	258,000	Common Stock
Michael Hayden	Director	Purchase of securities on an exchange or from another person at price $ 53.38 per share.	30 Jul 2026	15,000	19,000 (0%)	0%	53.4	800,700	Common Stock
Joan E. Herman	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jul 2026	5,220	2,301	-		-	Restricted Stock Unit
Joan E. Herman	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jul 2026	5,220	51,306 (0%)	0%		0	Common Stock
Spencer R. Berthelsen	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jul 2026	5,220	2,301	-		-	Restricted Stock Unit
Spencer R. Berthelsen	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jul 2026	5,220	161,233 (0%)	0%		0	Common Stock
Peter N. Reikes	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jul 2026	3,399	3,399	-		-	Restricted Stock Unit
Joseph Klein	Director	Sale of securities on an exchange or to another person at price $ 79.04 per share.	01 Jul 2026	11,419	11,014 (0%)	0%	79.0	902,551	Common Stock
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 39.94 per share.	01 Jul 2026	11,518	22,532 (0%)	0%	39.9	460,029	Common Stock
Joseph Klein	Director	Sale of securities on an exchange or to another person at price $ 79.45 per share.	01 Jul 2026	99	22,433 (0%)	0%	79.5	7,866	Common Stock
Joseph Klein	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Jul 2026	2,301	16,277	-		-	Restricted Stock Unit
Joseph Klein	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Jul 2026	5,369	5,369	-		-	Non-Qualified Stock Option (right to buy)
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Jul 2026	11,518	0	-		-	Non-Qualified Stock Option (right to buy)
Joseph Loscalzo	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Jul 2026	2,301	7,521	-		-	Restricted Stock Unit
Joseph Loscalzo	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Jul 2026	5,369	5,369	-		-	Non-Qualified Stock Option (right to buy)
Joan E. Herman	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Jul 2026	2,301	7,521	-		-	Restricted Stock Unit
Joan E. Herman	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Jul 2026	5,369	5,369	-		-	Non-Qualified Stock Option (right to buy)
Spencer R. Berthelsen	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Jul 2026	2,301	7,521	-		-	Restricted Stock Unit
Spencer R. Berthelsen	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Jul 2026	5,369	5,369	-		-	Non-Qualified Stock Option (right to buy)
Michael Hayden	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Jul 2026	2,301	12,198	-		-	Restricted Stock Unit
Michael Hayden	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Jul 2026	5,369	5,369	-		-	Non-Qualified Stock Option (right to buy)
Michael J. Yang	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Jul 2026	2,301	9,451	-		-	Restricted Stock Unit
Michael J. Yang	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Jul 2026	5,369	5,369	-		-	Non-Qualified Stock Option (right to buy)
Allene M. Diaz	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Jul 2026	2,301	7,521	-		-	Restricted Stock Unit
Allene M. Diaz	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Jul 2026	5,369	5,369	-		-	Non-Qualified Stock Option (right to buy)
Patrick R. O'Neil	EVP CLO & General Counsel	Sale of securities on an exchange or to another person at price $ 80.00 per share.	26 Jun 2026	3,069	61,470 (0%)	0%	80	245,520	Common Stock
Eugene Schneider	EVP, Chf Clinical Develop Ofcr	Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share.	26 Jun 2026	26,000	103,114 (0%)	0%	60.9	1,583,140	Common Stock
Eugene Schneider	EVP, Chf Clinical Develop Ofcr	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	26 Jun 2026	26,000	26,000	-		-	Non-Qualified Stock Option (right to buy)
Eugene Schneider	EVP, Chf Clinical Develop Ofcr	Sale of securities on an exchange or to another person at price $ 81.05 per share.	26 Jun 2026	26,000	77,114 (0%)	0%	81.0	2,107,196	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	24 Jun 2026	14,565	21,072	-		-	Non-Qualified Stock Option (right to buy)
Brett P. Monia	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 80.59 per share.	24 Jun 2026	50,000	245,571 (0%)	0%	80.6	4,029,500	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share.	24 Jun 2026	50,000	295,571 (0%)	0%	56.8	2,839,000	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 78.49 per share.	24 Jun 2026	21,072	245,571 (0%)	0%	78.5	1,653,941	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share.	24 Jun 2026	21,072	266,643 (0%)	0%	32.6	686,947	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 78.41 per share.	24 Jun 2026	14,565	245,571 (0%)	0%	78.4	1,142,082	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share.	24 Jun 2026	14,565	260,136 (0%)	0%	32.6	474,819	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	24 Jun 2026	50,000	99,872	-		-	Non-Qualified Stock Option (right to buy)
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	24 Jun 2026	21,072	0	-		-	Non-Qualified Stock Option (right to buy)
Spencer R. Berthelsen	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.42 per share.	15 Jun 2026	8,000	164,013 (0%)	0%	24.4	195,360	Common Stock
Spencer R. Berthelsen	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jun 2026	8,000	0	-		-	Non-Qualified Stock Option (right to buy)
Spencer R. Berthelsen	Director	Sale of securities on an exchange or to another person at price $ 73.49 per share.	15 Jun 2026	8,000	156,013 (0%)	0%	73.5	587,920	Common Stock
Holly B. Kordasiewicz	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 73.09 per share.	12 Jun 2026	41,004	42,300 (0%)	0%	73.1	2,997,122	Common Stock
Holly B. Kordasiewicz	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Jun 2026	12,000	0	-		-	Non-Qualified Stock Option (right to buy)
Holly B. Kordasiewicz	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Jun 2026	19,895	0	-		-	Non-Qualified Stock Option (right to buy)
Holly B. Kordasiewicz	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Jun 2026	7,951	21,000	-		-	Non-Qualified Stock Option (right to buy)
Holly B. Kordasiewicz	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Jun 2026	21,000	0	-		-	Non-Qualified Stock Option (right to buy)
Holly B. Kordasiewicz	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share.	12 Jun 2026	21,000	51,409 (0%)	0%	60.9	1,278,690	Common Stock
Holly B. Kordasiewicz	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 74.05 per share.	12 Jun 2026	19,842	22,458 (0%)	0%	74.1	1,469,306	Common Stock
Holly B. Kordasiewicz	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share.	12 Jun 2026	7,951	30,409 (0%)	0%	60.9	484,136	Common Stock
Holly B. Kordasiewicz	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share.	12 Jun 2026	12,000	63,409 (0%)	0%	32.6	391,200	Common Stock
Holly B. Kordasiewicz	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share.	12 Jun 2026	19,895	83,304 (0%)	0%	56.8	1,129,638	Common Stock
Peter N. Reikes	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	04 Jun 2026	10,753	10,753	-		-	Non-Qualified Stock Option (right to buy)
Spencer R. Berthelsen	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.42 per share.	01 Jun 2026	8,000	164,013 (0%)	0%	24.4	195,360	Common Stock
Spencer R. Berthelsen	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Jun 2026	8,000	8,000	-		-	Non-Qualified Stock Option (right to buy)
Spencer R. Berthelsen	Director	Sale of securities on an exchange or to another person at price $ 75.67 per share.	01 Jun 2026	8,000	156,013 (0%)	0%	75.7	605,360	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	13 May 2026	1,316	38,857	-		-	Non-Qualified Stock Option (right to buy)
Brett P. Monia	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 78.68 per share.	13 May 2026	3,220	242,662 (0%)	0%	78.7	253,347	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share.	13 May 2026	3,220	245,882 (0%)	0%	32.6	104,972	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 78.01 per share.	13 May 2026	1,316	242,662 (0%)	0%	78.0	102,665	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share.	13 May 2026	1,316	243,978 (0%)	0%	32.6	42,902	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	13 May 2026	3,220	35,637	-		-	Non-Qualified Stock Option (right to buy)
Joseph Loscalzo	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.06 per share.	04 May 2026	10,968	47,298 (0%)	0%	38.1	417,442	Common Stock
Joseph Loscalzo	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	04 May 2026	16,000	0	-		-	Non-Qualified Stock Option (right to buy)
Joseph Loscalzo	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	04 May 2026	12,000	0	-		-	Non-Qualified Stock Option (right to buy)
Joseph Loscalzo	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	04 May 2026	16,000	0	-		-	Non-Qualified Stock Option (right to buy)
Joseph Loscalzo	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	04 May 2026	10,321	0	-		-	Non-Qualified Stock Option (right to buy)
Joseph Loscalzo	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	04 May 2026	12,000	0	-		-	Non-Qualified Stock Option (right to buy)
Joseph Loscalzo	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	04 May 2026	10,968	0	-		-	Non-Qualified Stock Option (right to buy)
Joseph Loscalzo	Director	Sale of securities on an exchange or to another person at price $ 75.58 per share.	04 May 2026	17,781	36,330 (0%)	0%	75.6	1,343,934	Common Stock
Joseph Loscalzo	Director	Sale of securities on an exchange or to another person at price $ 74.90 per share.	04 May 2026	59,508	54,111 (0%)	0%	74.9	4,457,292	Common Stock
Joseph Loscalzo	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 64.80 per share.	04 May 2026	16,000	113,619 (0%)	0%	64.8	1,036,800	Common Stock
Joseph Loscalzo	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.20 per share.	04 May 2026	12,000	97,619 (0%)	0%	60.2	722,400	Common Stock
Joseph Loscalzo	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 42.88 per share.	04 May 2026	16,000	85,619 (0%)	0%	42.9	686,080	Common Stock
Joseph Loscalzo	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 41.08 per share.	04 May 2026	10,321	69,619 (0%)	0%	41.1	423,987	Common Stock
Joseph Loscalzo	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 40.05 per share.	04 May 2026	12,000	59,298 (0%)	0%	40.1	480,600	Common Stock
Joseph Klein	Director	Sale of securities on an exchange or to another person at price $ 74.45 per share.	01 May 2026	1,431	11,014 (0%)	0%	74.4	106,534	Common Stock
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 May 2026	10,111	0	-		-	Non-Qualified Stock Option (right to buy)
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.11 per share.	01 May 2026	10,111	21,125 (0%)	0%	47.1	476,329	Common Stock
Joseph Klein	Director	Sale of securities on an exchange or to another person at price $ 73.35 per share.	01 May 2026	8,680	12,445 (0%)	0%	73.4	636,704	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Sale of securities on an exchange or to another person at price $ 71.79 per share.	28 Apr 2026	1,626	44,909 (0%)	0%	71.8	116,727	Common Stock
B. Lynne Parshall	Director	Sale of securities on an exchange or to another person at price $ 76.97 per share.	15 Apr 2026	534	51,344 (0%)	0%	77.0	41,102	Common Stock
B. Lynne Parshall	Director	Sale of securities on an exchange or to another person at price $ 76.19 per share.	15 Apr 2026	4,466	51,878 (0%)	0%	76.2	340,265	Common Stock
Kyle Jenne	EVP, Chf GL Pdt Str Ofcr	Sale of securities on an exchange or to another person at price $ 75.17 per share.	15 Apr 2026	4,902	23,713 (0%)	0%	75.2	368,488	Common Stock
Kyle Jenne	EVP, Chf GL Pdt Str Ofcr	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Apr 2026	12,226	74,402	-		-	Restricted Stock Unit
Kyle Jenne	EVP, Chf GL Pdt Str Ofcr	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Apr 2026	12,226	28,615 (0%)	0%		0	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Apr 2026	10,837	52,154 (0%)	0%		0	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Sale of securities on an exchange or to another person at price $ 74.56 per share.	15 Apr 2026	5,619	46,535 (0%)	0%	74.6	418,953	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Apr 2026	10,837	48,312	-		-	Restricted Stock Unit
Brian Birchler	EVP, Corp and Development Ops	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Apr 2026	1,875	48,926	-		-	Restricted Stock Unit
Brian Birchler	EVP, Corp and Development Ops	Sale of securities on an exchange or to another person at price $ 75.04 per share.	15 Apr 2026	973	67,500 (0%)	0%	75.0	73,016	Common Stock
Brian Birchler	EVP, Corp and Development Ops	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Apr 2026	1,875	68,473 (0%)	0%		0	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Sale of securities on an exchange or to another person at price $ 74.05 per share.	02 Apr 2026	6,193	16,348 (0%)	0%	74.1	458,613	Common Stock
Joseph Klein	Director	Sale of securities on an exchange or to another person at price $ 75.95 per share.	01 Apr 2026	2,216	11,014 (0%)	0%	76.0	168,314	Common Stock
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Apr 2026	12,000	0	-		-	Non-Qualified Stock Option (right to buy)
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Apr 2026	10,321	0	-		-	Non-Qualified Stock Option (right to buy)
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 41.08 per share.	01 Apr 2026	10,321	33,335 (0%)	0%	41.1	423,987	Common Stock
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.06 per share.	01 Apr 2026	12,000	23,014 (0%)	0%	38.1	456,720	Common Stock
Joseph Klein	Director	Sale of securities on an exchange or to another person at price $ 75.50 per share.	01 Apr 2026	20,105	13,230 (0%)	0%	75.5	1,517,988	Common Stock
Eugene Schneider	EVP, Chf Clinical Develop Ofcr	Sale of securities on an exchange or to another person at price $ 70.97 per share.	19 Mar 2026	5,812	63,890 (0%)	0%	71.0	412,486	Common Stock
Elizabeth L. Hougen	EVP, Finance & CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share.	16 Mar 2026	60,299	193,180 (0%)	0%	60.9	3,671,606	Common Stock
Elizabeth L. Hougen	EVP, Finance & CFO	Sale of securities on an exchange or to another person at price $ 72.38 per share.	16 Mar 2026	205,608	102,272 (0%)	0%	72.4	14,882,113	Common Stock
Elizabeth L. Hougen	EVP, Finance & CFO	Sale of securities on an exchange or to another person at price $ 72.77 per share.	16 Mar 2026	9,440	92,832 (0%)	0%	72.8	686,902	Common Stock
Elizabeth L. Hougen	EVP, Finance & CFO	Sale of securities on an exchange or to another person at price $ 73.21 per share.	16 Mar 2026	10,172	82,660 (0%)	0%	73.2	744,662	Common Stock
Elizabeth L. Hougen	EVP, Finance & CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	16 Mar 2026	33,118	0	-		-	Non-Qualified Stock Option (right to buy)
Elizabeth L. Hougen	EVP, Finance & CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	16 Mar 2026	20,541	5,405	-		-	Non-Qualified Stock Option (right to buy)
Elizabeth L. Hougen	EVP, Finance & CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	16 Mar 2026	61,041	0	-		-	Non-Qualified Stock Option (right to buy)
Elizabeth L. Hougen	EVP, Finance & CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	16 Mar 2026	60,299	0	-		-	Non-Qualified Stock Option (right to buy)
Elizabeth L. Hougen	EVP, Finance & CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.58 per share.	16 Mar 2026	20,541	307,880 (0%)	0%	37.6	771,931	Common Stock
Elizabeth L. Hougen	EVP, Finance & CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share.	16 Mar 2026	33,118	287,339 (0%)	0%	32.6	1,079,647	Common Stock
Elizabeth L. Hougen	EVP, Finance & CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share.	16 Mar 2026	61,041	254,221 (0%)	0%	56.8	3,465,908	Common Stock
Kyle Jenne	EVP, Chf GL Pdt Str Ofcr	Sale of securities on an exchange or to another person at price $ 76.30 per share.	10 Mar 2026	16,086	11,714 (0%)	0%	76.3	1,227,362	Common Stock
Kyle Jenne	EVP, Chf GL Pdt Str Ofcr	Sale of securities on an exchange or to another person at price $ 75.50 per share.	10 Mar 2026	21,191	27,800 (0%)	0%	75.5	1,599,963	Common Stock
Kyle Jenne	EVP, Chf GL Pdt Str Ofcr	Exercise or conversion of derivative security received from the company (such as an option) at price $ 46.10 per share.	10 Mar 2026	32,602	48,991 (0%)	0%	46.1	1,502,952	Common Stock
Kyle Jenne	EVP, Chf GL Pdt Str Ofcr	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	10 Mar 2026	32,602	32,601	-		-	Non-Qualified Stock Option (right to buy)
Kyle Jenne	EVP, Chf GL Pdt Str Ofcr	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	10 Mar 2026	4,675	14,025	-		-	Non-Qualified Stock Option (right to buy)
Kyle Jenne	EVP, Chf GL Pdt Str Ofcr	Exercise or conversion of derivative security received from the company (such as an option) at price $ 34.69 per share.	10 Mar 2026	4,675	16,389 (0%)	0%	34.7	162,176	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 Mar 2026	34,103	0	-		-	Non-Qualified Stock Option (right to buy)
Brett P. Monia	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 75.58 per share.	09 Mar 2026	1,684	242,662 (0%)	0%	75.6	127,282	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 75.26 per share.	09 Mar 2026	117,604	244,346 (0%)	0%	75.3	8,850,642	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 74.11 per share.	09 Mar 2026	7,382	361,950 (0%)	0%	74.1	547,087	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share.	09 Mar 2026	73,529	369,332 (0%)	0%	60.9	4,477,181	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share.	09 Mar 2026	40,822	295,803 (0%)	0%	60.9	2,485,652	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 75.47 per share.	09 Mar 2026	16,512	260,253 (0%)	0%	75.5	1,246,235	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 76.34 per share.	09 Mar 2026	17,591	242,662 (0%)	0%	76.3	1,342,909	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 Mar 2026	40,822	107,632	-		-	Non-Qualified Stock Option (right to buy)
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 Mar 2026	73,529	34,103	-		-	Non-Qualified Stock Option (right to buy)
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share.	09 Mar 2026	34,103	276,765 (0%)	0%	60.9	2,076,532	Common Stock
Patrick R. O'Neil	EVP CLO & General Counsel	Sale of securities on an exchange or to another person at price $ 75.25 per share.	09 Mar 2026	10,148	62,211 (0%)	0%	75.3	763,662	Common Stock
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 40.05 per share.	03 Mar 2026	12,000	28,346 (0%)	0%	40.1	480,600	Common Stock
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 42.88 per share.	03 Mar 2026	4,000	32,346 (0%)	0%	42.9	171,520	Common Stock
Joseph Klein	Director	Sale of securities on an exchange or to another person at price $ 79.17 per share.	03 Mar 2026	13,526	18,820 (0%)	0%	79.2	1,070,908	Common Stock
Joseph Klein	Director	Sale of securities on an exchange or to another person at price $ 79.99 per share.	03 Mar 2026	6,794	12,026 (0%)	0%	80.0	543,486	Common Stock
Joseph Klein	Director	Sale of securities on an exchange or to another person at price $ 80.82 per share.	03 Mar 2026	1,012	11,014 (0%)	0%	80.8	81,788	Common Stock
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Mar 2026	12,000	0	-		-	Non-Qualified Stock Option (right to buy)
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Mar 2026	4,000	0	-		-	Non-Qualified Stock Option (right to buy)
Joseph Loscalzo	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Mar 2026	200	10,968	-		-	Non-Qualified Stock Option (right to buy)
Joseph Loscalzo	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Mar 2026	832	11,168	-		-	Non-Qualified Stock Option (right to buy)
Joseph Loscalzo	Director	Sale of securities on an exchange or to another person at price $ 80.00 per share.	03 Mar 2026	200	36,330 (0%)	0%	80	16,000	Common Stock
Joseph Loscalzo	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.06 per share.	03 Mar 2026	200	36,530 (0%)	0%	38.1	7,612	Common Stock
Joseph Loscalzo	Director	Sale of securities on an exchange or to another person at price $ 80.33 per share.	03 Mar 2026	832	36,330 (0%)	0%	80.3	66,833	Common Stock
Joseph Loscalzo	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.06 per share.	03 Mar 2026	832	37,162 (0%)	0%	38.1	31,666	Common Stock
C. Frank Bennett	EVP, Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Mar 2026	48,626	0	-		-	Non-Qualified Stock Option (right to buy)
C. Frank Bennett	EVP, Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share.	03 Mar 2026	16,463	117,017 (0%)	0%	32.6	536,694	Common Stock
C. Frank Bennett	EVP, Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share.	03 Mar 2026	48,626	165,643 (0%)	0%	60.9	2,960,837	Common Stock
C. Frank Bennett	EVP, Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 79.10 per share.	03 Mar 2026	71,600	94,043 (0%)	0%	79.1	5,663,488	Common Stock
C. Frank Bennett	EVP, Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 79.88 per share.	03 Mar 2026	12,687	81,356 (0%)	0%	79.9	1,013,410	Common Stock
C. Frank Bennett	EVP, Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 80.76 per share.	03 Mar 2026	802	80,554 (0%)	0%	80.8	64,771	Common Stock
C. Frank Bennett	EVP, Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Mar 2026	16,463	2,406	-		-	Non-Qualified Stock Option (right to buy)
Allene M. Diaz	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.06 per share.	03 Mar 2026	12,000	40,689 (0%)	0%	38.1	456,720	Common Stock
Allene M. Diaz	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Mar 2026	10,321	0	-		-	Non-Qualified Stock Option (right to buy)
Allene M. Diaz	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Mar 2026	18,000	0	-		-	Non-Qualified Stock Option (right to buy)
Allene M. Diaz	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Mar 2026	12,000	0	-		-	Non-Qualified Stock Option (right to buy)
Allene M. Diaz	Director	Sale of securities on an exchange or to another person at price $ 80.80 per share.	03 Mar 2026	1,005	3,811 (0%)	0%	80.8	81,203	Common Stock
Allene M. Diaz	Director	Sale of securities on an exchange or to another person at price $ 79.88 per share.	03 Mar 2026	14,608	4,816 (0%)	0%	79.9	1,166,814	Common Stock
Allene M. Diaz	Director	Sale of securities on an exchange or to another person at price $ 79.11 per share.	03 Mar 2026	39,265	19,424 (0%)	0%	79.1	3,106,411	Common Stock
Allene M. Diaz	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 40.05 per share.	03 Mar 2026	18,000	58,689 (0%)	0%	40.1	720,900	Common Stock
Allene M. Diaz	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 41.08 per share.	03 Mar 2026	10,321	28,689 (0%)	0%	41.1	423,987	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Sale of securities on an exchange or to another person at price $ 79.36 per share.	03 Mar 2026	4,096	41,317 (0%)	0%	79.4	325,059	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share.	03 Mar 2026	820	5,592 (0%)	0%	56.8	46,560	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share.	03 Mar 2026	879	6,471 (0%)	0%	32.6	28,655	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Sale of securities on an exchange or to another person at price $ 80.41 per share.	03 Mar 2026	2,088	4,383 (0%)	0%	80.4	167,892	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Sale of securities on an exchange or to another person at price $ 81.00 per share.	03 Mar 2026	36	4,347 (0%)	0%	81	2,916	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share.	03 Mar 2026	238	4,585 (0%)	0%	56.8	13,514	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Sale of securities on an exchange or to another person at price $ 80.00 per share.	03 Mar 2026	238	4,347 (0%)	0%	80	19,040	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share.	03 Mar 2026	201	4,548 (0%)	0%	32.6	6,553	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Sale of securities on an exchange or to another person at price $ 80.00 per share.	03 Mar 2026	201	4,347 (0%)	0%	80	16,080	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Mar 2026	201	1,769	-		-	Non-Qualified Stock Option (right to buy)
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Mar 2026	238	3,866	-		-	Non-Qualified Stock Option (right to buy)
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Mar 2026	879	1,970	-		-	Non-Qualified Stock Option (right to buy)
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Mar 2026	820	4,104	-		-	Non-Qualified Stock Option (right to buy)
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Mar 2026	3,510	5,744	-		-	Non-Qualified Stock Option (right to buy)
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Mar 2026	385	8,877	-		-	Non-Qualified Stock Option (right to buy)
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Mar 2026	3,760	11,280	-		-	Non-Qualified Stock Option (right to buy)
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Mar 2026	5,500	16,500	-		-	Non-Qualified Stock Option (right to buy)
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Mar 2026	6,951	928	-		-	Non-Qualified Stock Option (right to buy)
Shannon L. Devers	EVP, Chief Human Resources Ofc	Sale of securities on an exchange or to another person at price $ 80.84 per share.	03 Mar 2026	755	22,541 (0%)	0%	80.8	61,032	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Sale of securities on an exchange or to another person at price $ 80.00 per share.	03 Mar 2026	5,030	23,296 (0%)	0%	80.0	402,395	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Sale of securities on an exchange or to another person at price $ 79.12 per share.	03 Mar 2026	14,321	28,326 (0%)	0%	79.1	1,133,006	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.87 per share.	03 Mar 2026	385	42,647 (0%)	0%	52.9	20,355	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share.	03 Mar 2026	6,951	42,262 (0%)	0%	32.6	226,603	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 34.69 per share.	03 Mar 2026	5,500	35,311 (0%)	0%	34.7	190,795	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 40.85 per share.	03 Mar 2026	3,760	29,811 (0%)	0%	40.9	153,596	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.58 per share.	03 Mar 2026	3,510	26,051 (0%)	0%	37.6	131,906	Common Stock
C. Frank Bennett	EVP, Chief Scientific Officer	Other type of transaction at price $ 48.87 per share.	27 Feb 2026	261	100,554 (0%)	0%	48.9	12,754	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Other type of transaction at price $ 48.87 per share.	27 Feb 2026	484	254,981 (0%)	0%	48.9	23,651	Common Stock
Patrick R. O'Neil	EVP CLO & General Counsel	Other type of transaction at price $ 48.87 per share.	27 Feb 2026	376	72,359 (0%)	0%	48.9	18,374	Common Stock
Eric E. Swayze	EVP Research	Other type of transaction at price $ 48.87 per share.	27 Feb 2026	256	32,361 (0%)	0%	48.9	12,510	Common Stock
Brian Birchler	EVP, Corp and Development Ops	Other type of transaction at price $ 48.87 per share.	27 Feb 2026	351	66,598 (0%)	0%	48.9	17,152	Common Stock
Eric E. Swayze	EVP Research	Sale of securities on an exchange or to another person at price $ 81.56 per share.	13 Feb 2026	9,435	38,312 (0%)	0%	81.6	769,511	Common Stock
Eric E. Swayze	EVP Research	Sale of securities on an exchange or to another person at price $ 82.07 per share.	13 Feb 2026	6,207	32,105 (0%)	0%	82.1	509,403	Common Stock
B. Lynne Parshall	Director	Sale of securities on an exchange or to another person at price $ 82.72 per share.	11 Feb 2026	5,000	56,344 (0%)	0%	82.7	413,589	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 85.79 per share.	06 Feb 2026	29,430	254,497 (0%)	0%	85.8	2,524,820	Common Stock
C. Frank Bennett	EVP, Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 82.60 per share.	02 Feb 2026	20,000	80,293 (0%)	0%	82.6	1,651,980	Common Stock
C. Frank Bennett	EVP, Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	02 Feb 2026	48,626	0	-		-	Non-Qualified Stock Option (right to buy)
C. Frank Bennett	EVP, Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	02 Feb 2026	16,463	2,406	-		-	Non-Qualified Stock Option (right to buy)
C. Frank Bennett	EVP, Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 83.03 per share.	02 Feb 2026	16,463	80,293 (0%)	0%	83.0	1,366,897	Common Stock
C. Frank Bennett	EVP, Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share.	02 Feb 2026	16,463	96,756 (0%)	0%	32.6	536,694	Common Stock
C. Frank Bennett	EVP, Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 83.03 per share.	02 Feb 2026	48,626	80,293 (0%)	0%	83.0	4,037,339	Common Stock
C. Frank Bennett	EVP, Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share.	02 Feb 2026	48,626	128,919 (0%)	0%	60.9	2,960,837	Common Stock
C. Frank Bennett	EVP, Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 Jan 2026	11,421	106,178 (0%)	0%		0	Common Stock
C. Frank Bennett	EVP, Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 82.95 per share.	29 Jan 2026	5,885	100,293 (0%)	0%	82.9	488,141	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 Jan 2026	122,214	346,897 (0%)	0%		0	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 82.72 per share.	29 Jan 2026	62,970	283,927 (0%)	0%	82.7	5,208,979	Common Stock
Elizabeth L. Hougen	EVP, Finance & CFO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 Jan 2026	13,562	139,869 (0%)	0%		0	Common Stock
Elizabeth L. Hougen	EVP, Finance & CFO	Sale of securities on an exchange or to another person at price $ 83.24 per share.	29 Jan 2026	6,988	132,881 (0%)	0%	83.2	581,702	Common Stock
Patrick R. O'Neil	EVP CLO & General Counsel	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 Jan 2026	11,991	78,162 (0%)	0%		0	Common Stock
Patrick R. O'Neil	EVP CLO & General Counsel	Sale of securities on an exchange or to another person at price $ 83.53 per share.	29 Jan 2026	6,179	71,983 (0%)	0%	83.5	516,153	Common Stock
Eric E. Swayze	EVP Research	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 Jan 2026	11,991	53,926 (0%)	0%		0	Common Stock
Eric E. Swayze	EVP Research	Sale of securities on an exchange or to another person at price $ 82.93 per share.	29 Jan 2026	6,179	47,747 (0%)	0%	82.9	512,446	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Sale of securities on an exchange or to another person at price $ 82.96 per share.	29 Jan 2026	5,296	45,413 (0%)	0%	83.0	439,364	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 Jan 2026	10,278	50,709 (0%)	0%		0	Common Stock
Eugene Schneider	EVP, Chf Clinical Develop Ofcr	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 Jan 2026	11,991	75,881 (0%)	0%		0	Common Stock
Eugene Schneider	EVP, Chf Clinical Develop Ofcr	Sale of securities on an exchange or to another person at price $ 83.45 per share.	29 Jan 2026	6,179	69,702 (0%)	0%	83.4	515,630	Common Stock
Brian Birchler	EVP, Corp and Development Ops	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 Jan 2026	11,991	72,426 (0%)	0%		0	Common Stock
Brian Birchler	EVP, Corp and Development Ops	Sale of securities on an exchange or to another person at price $ 83.03 per share.	29 Jan 2026	6,179	66,247 (0%)	0%	83.0	513,048	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Sale of securities on an exchange or to another person at price $ 81.34 per share.	22 Jan 2026	3,977	22,541 (0%)	0%	81.3	323,490	Common Stock
Eric E. Swayze	EVP Research	Sale of securities on an exchange or to another person at price $ 75.98 per share.	15 Jan 2026	49	318 (0%)	0%	76.0	3,723	Common Stock
Eric E. Swayze	EVP Research	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	111	367 (0%)	0%		0	Common Stock
Eric E. Swayze	EVP Research	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	21,366	51,819 (0%)	0%		0	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	17,037	49,474	-		-	Restricted Stock Unit
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	17,037	47,338 (0%)	0%		0	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Sale of securities on an exchange or to another person at price $ 75.75 per share.	15 Jan 2026	6,907	40,431 (0%)	0%	75.7	523,205	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	2,850	5,921 (0%)	0%		0	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Sale of securities on an exchange or to another person at price $ 75.78 per share.	15 Jan 2026	1,149	4,772 (0%)	0%	75.8	87,071	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	9,675	59,149	-		-	Restricted Stock Unit
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	2,850	5,474	-		-	Restricted Stock Unit
Joseph T. Baroldi	EVP, Chief Business Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	25,800	77,090	-		-	Performance Restricted Stock Units
Joseph T. Baroldi	EVP, Chief Business Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	3,900	9,374	-		-	Restricted Stock Unit
Eugene Schneider	EVP, Chf Clinical Develop Ofcr	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	21,685	73,192 (0%)	0%		0	Common Stock
Eugene Schneider	EVP, Chf Clinical Develop Ofcr	Sale of securities on an exchange or to another person at price $ 75.59 per share.	15 Jan 2026	9,302	63,890 (0%)	0%	75.6	703,138	Common Stock
Eugene Schneider	EVP, Chf Clinical Develop Ofcr	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	25,800	91,237	-		-	Performance Restricted Stock Units
Eugene Schneider	EVP, Chf Clinical Develop Ofcr	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	21,685	39,251	-		-	Restricted Stock Unit
Eugene Schneider	EVP, Chf Clinical Develop Ofcr	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	9,675	48,926	-		-	Restricted Stock Unit
Brian Birchler	EVP, Corp and Development Ops	Sale of securities on an exchange or to another person at price $ 75.11 per share.	15 Jan 2026	8,480	60,435 (0%)	0%	75.1	636,933	Common Stock
Brian Birchler	EVP, Corp and Development Ops	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	20,089	68,915 (0%)	0%		0	Common Stock
Brian Birchler	EVP, Corp and Development Ops	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	9,675	50,801	-		-	Restricted Stock Unit
Brian Birchler	EVP, Corp and Development Ops	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	20,089	41,126	-		-	Restricted Stock Unit
Brian Birchler	EVP, Corp and Development Ops	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	25,800	79,138	-		-	Performance Restricted Stock Units
Shannon L. Devers	EVP, Chief Human Resources Ofc	Sale of securities on an exchange or to another person at price $ 75.95 per share.	15 Jan 2026	8,353	26,518 (0%)	0%	75.9	634,410	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	9,675	52,704	-		-	Restricted Stock Unit
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	17,377	43,029	-		-	Restricted Stock Unit
Shannon L. Devers	EVP, Chief Human Resources Ofc	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	25,800	47,800	-		-	Performance Restricted Stock Units
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	17,377	34,871 (0%)	0%		0	Common Stock
Holly B. Kordasiewicz	EVP, Chief Development Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	13,650	34,480	-		-	Restricted Stock Unit
Holly B. Kordasiewicz	EVP, Chief Development Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	11,250	45,730	-		-	Restricted Stock Unit
Holly B. Kordasiewicz	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	11,119	20,830	-		-	Restricted Stock Unit
Holly B. Kordasiewicz	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 75.66 per share.	15 Jan 2026	4,141	14,718 (0%)	0%	75.7	313,308	Common Stock
Holly B. Kordasiewicz	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	11,119	18,859 (0%)	0%		0	Common Stock
C. Frank Bennett	EVP, Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	9,675	27,109	-		-	Restricted Stock Unit
C. Frank Bennett	EVP, Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	21,055	103,734 (0%)	0%		0	Common Stock
C. Frank Bennett	EVP, Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 75.15 per share.	15 Jan 2026	8,977	94,757 (0%)	0%	75.2	674,622	Common Stock
C. Frank Bennett	EVP, Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	25,800	89,282	-		-	Performance Restricted Stock Units
C. Frank Bennett	EVP, Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	21,055	17,434	-		-	Restricted Stock Unit
Brett P. Monia	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 74.82 per share.	15 Jan 2026	44,034	224,683 (0%)	0%	74.8	3,294,624	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	42,705	205,719	-		-	Restricted Stock Unit
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	89,145	163,014	-		-	Restricted Stock Unit
Brett P. Monia	Director, Chief Executive Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	113,880	744,081	-		-	Performance Restricted Stock Units
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	89,145	268,717 (0%)	0%		0	Common Stock
Elizabeth L. Hougen	EVP, Finance & CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	28,729	55,940	-		-	Restricted Stock Unit
Elizabeth L. Hougen	EVP, Finance & CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	28,729	139,229 (0%)	0%		0	Common Stock
Elizabeth L. Hougen	EVP, Finance & CFO	Sale of securities on an exchange or to another person at price $ 75.22 per share.	15 Jan 2026	12,922	126,307 (0%)	0%	75.2	971,993	Common Stock
Elizabeth L. Hougen	EVP, Finance & CFO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	12,885	68,825	-		-	Restricted Stock Unit
Elizabeth L. Hougen	EVP, Finance & CFO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	34,360	120,995	-		-	Performance Restricted Stock Units
Patrick R. O'Neil	EVP CLO & General Counsel	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	9,675	48,926	-		-	Restricted Stock Unit
Patrick R. O'Neil	EVP CLO & General Counsel	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	21,473	75,362 (0%)	0%		0	Common Stock
Patrick R. O'Neil	EVP CLO & General Counsel	Sale of securities on an exchange or to another person at price $ 75.84 per share.	15 Jan 2026	9,191	66,171 (0%)	0%	75.8	697,045	Common Stock
Patrick R. O'Neil	EVP CLO & General Counsel	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	25,800	90,601	-		-	Performance Restricted Stock Units
Patrick R. O'Neil	EVP CLO & General Counsel	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	21,473	39,251	-		-	Restricted Stock Unit
Michael J. Yang	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	1,930	7,940 (0%)	0%		0	Common Stock
Michael J. Yang	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	1,930	7,150	-		-	Restricted Stock Unit
Kyle Jenne	EVP, Chf GL Pdt Str Ofcr	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	25,800	44,500	-		-	Performance Restricted Stock Units
Kyle Jenne	EVP, Chf GL Pdt Str Ofcr	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	9,675	37,725	-		-	Restricted Stock Unit
Kyle Jenne	EVP, Chf GL Pdt Str Ofcr	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	7,013	29,664	-		-	Restricted Stock Unit
Kyle Jenne	EVP, Chf GL Pdt Str Ofcr	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	7,013	18,212 (0%)	0%		0	Common Stock
Kyle Jenne	EVP, Chf GL Pdt Str Ofcr	Sale of securities on an exchange or to another person at price $ 75.96 per share.	15 Jan 2026	1,823	16,389 (0%)	0%	76.0	138,475	Common Stock
Eric E. Swayze	EVP Research	Sale of securities on an exchange or to another person at price $ 75.34 per share.	15 Jan 2026	9,884	41,935 (0%)	0%	75.3	744,661	Common Stock
Eric E. Swayze	EVP Research	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	225	611	-		-	Restricted Stock Unit
Eric E. Swayze	EVP Research	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	111	386	-		-	Restricted Stock Unit
Eric E. Swayze	EVP Research	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	9,675	48,926	-		-	Restricted Stock Unit
Eric E. Swayze	EVP Research	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jan 2026	21,366	39,251	-		-	Restricted Stock Unit
Eric E. Swayze	EVP Research	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	25,800	90,282	-		-	Performance Restricted Stock Units
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share.	07 Jan 2026	25,545	43,039 (0%)	0%	56.8	1,450,445	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	07 Jan 2026	25,545	2,971	-		-	Non-Qualified Stock Option (right to buy)
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	07 Jan 2026	9,264	9,262	-		-	Non-Qualified Stock Option (right to buy)
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	07 Jan 2026	3,829	9,254	-		-	Non-Qualified Stock Option (right to buy)
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	07 Jan 2026	3,460	7,879	-		-	Non-Qualified Stock Option (right to buy)
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	07 Jan 2026	2,101	11,339	-		-	Non-Qualified Stock Option (right to buy)
Shannon L. Devers	EVP, Chief Human Resources Ofc	Sale of securities on an exchange or to another person at price $ 84.62 per share.	07 Jan 2026	9,264	17,494 (0%)	0%	84.6	783,920	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.87 per share.	07 Jan 2026	9,264	26,758 (0%)	0%	52.9	489,788	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Sale of securities on an exchange or to another person at price $ 84.62 per share.	07 Jan 2026	3,829	17,494 (0%)	0%	84.6	324,010	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.58 per share.	07 Jan 2026	3,829	21,323 (0%)	0%	37.6	143,894	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Sale of securities on an exchange or to another person at price $ 84.62 per share.	07 Jan 2026	3,460	17,494 (0%)	0%	84.6	292,785	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share.	07 Jan 2026	3,460	20,954 (0%)	0%	32.6	112,796	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Sale of securities on an exchange or to another person at price $ 85.36 per share.	07 Jan 2026	2,101	17,494 (0%)	0%	85.4	179,341	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share.	07 Jan 2026	2,101	19,595 (0%)	0%	32.6	68,493	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Sale of securities on an exchange or to another person at price $ 85.36 per share.	07 Jan 2026	25,545	17,494 (0%)	0%	85.4	2,180,521	Common Stock
C. Frank Bennett	EVP, Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Jan 2026	19,350	19,350	-		-	Non-Qualified Stock Option (right to buy)
Brett P. Monia	Director, Chief Executive Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Jan 2026	85,410	85,410	-		-	Non-Qualified Stock Option (right to buy)
Elizabeth L. Hougen	EVP, Finance & CFO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Jan 2026	25,770	25,770	-		-	Non-Qualified Stock Option (right to buy)
Patrick R. O'Neil	EVP CLO & General Counsel	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Jan 2026	19,350	19,350	-		-	Non-Qualified Stock Option (right to buy)
Kyle Jenne	EVP, Chf GL Pdt Str Ofcr	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Jan 2026	19,350	19,350	-		-	Non-Qualified Stock Option (right to buy)
Eric E. Swayze	EVP Research	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Jan 2026	150	150	-		-	Non-Qualified Stock Option (right to buy)
Eric E. Swayze	EVP Research	Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share.	02 Jan 2026	5,125	35,578 (0%)	0%	60.9	312,061	Common Stock
Eric E. Swayze	EVP Research	Sale of securities on an exchange or to another person at price $ 78.57 per share.	02 Jan 2026	5,125	30,453 (0%)	0%	78.6	402,671	Common Stock
Eric E. Swayze	EVP Research	Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share.	02 Jan 2026	18,338	48,791 (0%)	0%	60.9	1,116,601	Common Stock
Eric E. Swayze	EVP Research	Sale of securities on an exchange or to another person at price $ 79.27 per share.	02 Jan 2026	18,338	30,453 (0%)	0%	79.3	1,453,653	Common Stock
Eric E. Swayze	EVP Research	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	02 Jan 2026	5,125	22,403	-		-	Non-Qualified Stock Option (right to buy)
Eric E. Swayze	EVP Research	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	02 Jan 2026	18,338	4,065	-		-	Non-Qualified Stock Option (right to buy)
Eric E. Swayze	EVP Research	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Jan 2026	19,350	19,350	-		-	Non-Qualified Stock Option (right to buy)
Joseph T. Baroldi	EVP, Chief Business Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Jan 2026	19,350	19,350	-		-	Non-Qualified Stock Option (right to buy)
Joseph T. Baroldi	EVP, Chief Business Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Jan 2026	2,600	2,600	-		-	Non-Qualified Stock Option (right to buy)
Eugene Schneider	EVP, Chf Clinical Develop Ofcr	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Jan 2026	19,350	19,350	-		-	Non-Qualified Stock Option (right to buy)
Brian Birchler	EVP, Corp and Development Ops	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Jan 2026	19,350	19,350	-		-	Non-Qualified Stock Option (right to buy)
Shannon L. Devers	EVP, Chief Human Resources Ofc	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Jan 2026	19,350	19,350	-		-	Non-Qualified Stock Option (right to buy)
Holly B. Kordasiewicz	EVP, Chief Development Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Jan 2026	9,100	9,100	-		-	Non-Qualified Stock Option (right to buy)
Holly B. Kordasiewicz	EVP, Chief Development Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Jan 2026	7,500	16,600	-		-	Non-Qualified Stock Option (right to buy)
Joseph H. Wender	Director	Sale of securities on an exchange or to another person at price $ 80.67 per share.	01 Dec 2025	20,571	43,464 (0%)	0%	80.7	1,659,362	Common Stock
Joseph H. Wender	Director	Sale of securities on an exchange or to another person at price $ 81.23 per share.	01 Dec 2025	7,429	36,035 (0%)	0%	81.2	603,486	Common Stock
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	25 Nov 2025	4,000	4,000 (0%)	0%		0	Common Stock
Joseph Klein	Director	Sale of securities on an exchange or to another person at price $ 80.00 per share.	25 Nov 2025	4,000	0 (0%)	0%	80	320,000	Common Stock
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	25 Nov 2025	4,000	4,000	-		-	Non-Qualified Stock Option (right to buy)
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	25 Nov 2025	4,000	8,000	-		-	Non-Qualified Stock Option (right to buy)
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	25 Nov 2025	4,000	0	-		-	Non-Qualified Stock Option (right to buy)
Joseph Klein	Director	Sale of securities on an exchange or to another person at price $ 80.00 per share.	25 Nov 2025	4,000	0 (0%)	0%	80	320,000	Common Stock
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	25 Nov 2025	4,000	4,000 (0%)	0%		0	Common Stock
Joseph Klein	Director	Sale of securities on an exchange or to another person at price $ 80.00 per share.	25 Nov 2025	4,000	0 (0%)	0%	80	320,000	Common Stock
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	25 Nov 2025	4,000	4,000 (0%)	0%		0	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Sale of securities on an exchange or to another person at price $ 80.91 per share.	25 Nov 2025	16,777	17,494 (0%)	0%	80.9	1,357,442	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share.	25 Nov 2025	16,777	34,271 (0%)	0%	53.8	902,099	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	25 Nov 2025	16,777	0	-		-	Non-Qualified Stock Option (right to buy)
Joan E. Herman	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 40.05 per share.	19 Nov 2025	12,000	58,086 (0%)	0%	40.1	480,600	Common Stock
Joan E. Herman	Director	Sale of securities on an exchange or to another person at price $ 72.13 per share.	19 Nov 2025	32,000	46,086 (0%)	0%	72.1	2,308,240	Common Stock
Joan E. Herman	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.90 per share.	19 Nov 2025	32,000	78,086 (0%)	0%	63.9	2,044,800	Common Stock
Joan E. Herman	Director	Sale of securities on an exchange or to another person at price $ 72.13 per share.	19 Nov 2025	12,000	46,086 (0%)	0%	72.1	865,590	Common Stock
Joan E. Herman	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	19 Nov 2025	32,000	0	-		-	Non-Qualified Stock Option (right to buy)
Joan E. Herman	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	19 Nov 2025	12,000	0	-		-	Non-Qualified Stock Option (right to buy)
Joseph H. Wender	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.42 per share.	18 Nov 2025	16,000	16,000 (0%)	0%	24.4	390,720	Common Stock
Joseph H. Wender	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	18 Nov 2025	16,000	0	-		-	Non-Qualified Stock Option (right to buy)
Brian Birchler	EVP, Corp and Development Ops		06 Nov 2025	8,000	48,826 (0%)	0%	76.2	609,379	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 76.10 per share.	05 Nov 2025	14,738	59,657 (0%)	0%	76.1	1,121,521	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share.	05 Nov 2025	14,738	74,395 (0%)	0%	56.8	836,824	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 75.01 per share.	05 Nov 2025	801	59,657 (0%)	0%	75.0	60,083	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share.	05 Nov 2025	801	60,458 (0%)	0%	60.9	48,773	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 75.01 per share.	05 Nov 2025	800	59,657 (0%)	0%	75.0	60,008	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share.	05 Nov 2025	800	60,457 (0%)	0%	56.8	45,424	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Nov 2025	18,300	0	-		-	Non-Qualified Stock Option (right to buy)
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Nov 2025	801	18,300	-		-	Non-Qualified Stock Option (right to buy)
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Nov 2025	14,738	0	-		-	Non-Qualified Stock Option (right to buy)
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Nov 2025	800	14,738	-		-	Non-Qualified Stock Option (right to buy)
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share.	05 Nov 2025	18,300	77,957 (0%)	0%	60.9	1,114,287	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 75.42 per share.	05 Nov 2025	18,300	59,657 (0%)	0%	75.4	1,380,204	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 75.05 per share.	03 Nov 2025	905	59,657 (0%)	0%	75.1	67,924	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Nov 2025	905	15,538	-		-	Non-Qualified Stock Option (right to buy)
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share.	03 Nov 2025	905	60,562 (0%)	0%	56.8	51,386	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 75.05 per share.	03 Nov 2025	775	59,657 (0%)	0%	75.1	58,167	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Nov 2025	775	19,101	-		-	Non-Qualified Stock Option (right to buy)
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share.	03 Nov 2025	775	60,432 (0%)	0%	60.9	47,190	Common Stock
Joseph Loscalzo	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.22 per share.	31 Oct 2025	16,000	52,330 (0%)	0%	52.2	835,520	Common Stock
Joseph Loscalzo	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	31 Oct 2025	16,000	0	-		-	Non-Qualified Stock Option (right to buy)
Joseph Loscalzo	Director	Sale of securities on an exchange or to another person at price $ 75.10 per share.	31 Oct 2025	16,000	36,330 (0%)	0%	75.1	1,201,669	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	31 Oct 2025	34,585	19,876	-		-	Non-Qualified Stock Option (right to buy)
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	31 Oct 2025	34,664	16,443	-		-	Non-Qualified Stock Option (right to buy)
Richard S. Geary	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 75.05 per share.	31 Oct 2025	905	59,657 (0%)	0%	75.1	67,924	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share.	31 Oct 2025	905	60,562 (0%)	0%	60.9	55,105	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 75.05 per share.	31 Oct 2025	775	59,657 (0%)	0%	75.1	58,167	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share.	31 Oct 2025	775	60,432 (0%)	0%	56.8	44,005	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 75.11 per share.	31 Oct 2025	20,000	59,657 (0%)	0%	75.1	1,502,166	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 75.11 per share.	31 Oct 2025	34,664	79,657 (0%)	0%	75.1	2,603,554	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share.	31 Oct 2025	34,664	114,321 (0%)	0%	56.8	1,968,222	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 75.11 per share.	31 Oct 2025	34,585	79,657 (0%)	0%	75.1	2,597,621	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share.	31 Oct 2025	34,585	114,242 (0%)	0%	60.9	2,105,881	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	31 Oct 2025	905	18,971	-		-	Non-Qualified Stock Option (right to buy)
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	31 Oct 2025	775	15,668	-		-	Non-Qualified Stock Option (right to buy)
Joseph H. Wender	Director	Sale of securities on an exchange or to another person at price $ 73.16 per share.	30 Oct 2025	8,341	81,210 (0%)	0%	73.2	610,228	Common Stock
Joseph H. Wender	Director	Sale of securities on an exchange or to another person at price $ 72.19 per share.	30 Oct 2025	2,484	89,551 (0%)	0%	72.2	179,320	Common Stock
Joseph H. Wender	Director	Sale of securities on an exchange or to another person at price $ 75.16 per share.	30 Oct 2025	11,200	64,035 (0%)	0%	75.2	841,776	Common Stock
Joseph H. Wender	Director	Sale of securities on an exchange or to another person at price $ 73.85 per share.	30 Oct 2025	5,975	75,235 (0%)	0%	73.9	441,254	Common Stock
B. Lynne Parshall	Director	Sale of securities on an exchange or to another person at price $ 71.74 per share.	15 Oct 2025	5,000	61,344 (0%)	0%	71.7	358,722	Common Stock
Eric E. Swayze	EVP Research		15 Oct 2025	125	497	-		-	Restricted Stock Unit
Eric E. Swayze	EVP Research		15 Oct 2025	53	256 (0%)	0%	73.6	3,902	Common Stock
Eric E. Swayze	EVP Research		15 Oct 2025	125	309 (0%)	0%		0	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 48.51 per share.	15 Oct 2025	6,000	21,937 (0%)	0%	48.5	291,060	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Oct 2025	2,820	60,406	-		-	Restricted Stock Unit
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Oct 2025	6,000	0	-		-	Non-Qualified Stock Option (right to buy)
Shannon L. Devers	EVP, Chief Human Resources Ofc	Sale of securities on an exchange or to another person at price $ 73.62 per share.	15 Oct 2025	1,263	17,494 (0%)	0%	73.6	92,984	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Oct 2025	2,820	18,757 (0%)	0%		0	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Sale of securities on an exchange or to another person at price $ 72.94 per share.	15 Oct 2025	6,000	15,937 (0%)	0%	72.9	437,654	Common Stock
Brian Birchler	EVP, Corp and Development Ops		14 Oct 2025	12,425	0	-		-	Non-Qualified Stock Option (right to buy)
Brian Birchler	EVP, Corp and Development Ops		14 Oct 2025	11,475	12,425	-		-	Non-Qualified Stock Option (right to buy)
Brian Birchler	EVP, Corp and Development Ops		14 Oct 2025	12,425	56,826 (0%)	0%	72.2	897,398	Common Stock
Brian Birchler	EVP, Corp and Development Ops		14 Oct 2025	12,425	69,251 (0%)	0%	53.8	668,092	Common Stock
Brian Birchler	EVP, Corp and Development Ops		14 Oct 2025	11,475	56,826 (0%)	0%	72.0	826,589	Common Stock
Brian Birchler	EVP, Corp and Development Ops		14 Oct 2025	11,475	68,301 (0%)	0%	53.8	617,011	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 69.26 per share.	06 Oct 2025	437	179,572 (0%)	0%	69.3	30,268	Common Stock
Patrick R. O'Neil	EVP CLO & General Counsel	Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.87 per share.	06 Oct 2025	10,200	67,330 (0%)	0%	52.9	539,274	Common Stock
Patrick R. O'Neil	EVP CLO & General Counsel	Sale of securities on an exchange or to another person at price $ 69.89 per share.	06 Oct 2025	10,200	57,130 (0%)	0%	69.9	712,849	Common Stock
Patrick R. O'Neil	EVP CLO & General Counsel	Sale of securities on an exchange or to another person at price $ 69.27 per share.	06 Oct 2025	3,241	53,889 (0%)	0%	69.3	224,488	Common Stock
Patrick R. O'Neil	EVP CLO & General Counsel	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	06 Oct 2025	10,200	17,000	-		-	Non-Qualified Stock Option (right to buy)
Eric E. Swayze	EVP Research		06 Oct 2025	6,849	30,453 (0%)	0%	69.0	472,718	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Sale of securities on an exchange or to another person at price $ 69.37 per share.	06 Oct 2025	1,625	30,301 (0%)	0%	69.4	112,725	Common Stock
Patrick R. O'Neil	EVP CLO & General Counsel	Sale of securities on an exchange or to another person at price $ 67.69 per share.	02 Oct 2025	30,203	57,130 (0%)	0%	67.7	2,044,417	Common Stock
R. Patrick O'Neil	EVP CLO & General Counsel	Sale of securities on an exchange or to another person at price $ 67.69 per share.	02 Oct 2025	34,461	57,130 (0%)	0%	67.7	2,332,638	Common Stock
O'Neil R. Patrick	EVP CLO & General Counsel	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	02 Oct 2025	30,203	0	-		-	Non-Qualified Stock Option (right to buy)
Baroldi Joseph T.	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.80 per share.	02 Oct 2025	15,000	46,926 (0%)	0%	31.8	477,000	Common Stock
Patrick O'Neil R.	EVP CLO & General Counsel	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	02 Oct 2025	34,461	0	-		-	Non-Qualified Stock Option (right to buy)
O'Neil R. Patrick	EVP CLO & General Counsel	Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share.	02 Oct 2025	30,203	87,333 (0%)	0%	56.8	1,714,926	Common Stock
Joseph Baroldi T.	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	02 Oct 2025	15,000	26,700	-		-	Non-Qualified Stock Option (right to buy)
R. Patrick O'Neil	EVP CLO & General Counsel	Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share.	02 Oct 2025	34,461	91,591 (0%)	0%	60.9	2,098,330	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Sale of securities on an exchange or to another person at price $ 68.01 per share.	02 Oct 2025	15,000	31,926 (0%)	0%	68.0	1,020,210	Common Stock
Swayze Eric E.	EVP Research		01 Oct 2025	12,972	0	-		-	Non-Qualified Stock Option (right to buy)
Eric E. Swayze	EVP Research		01 Oct 2025	14,142	37,302 (0%)	0%	66.1	934,662	Common Stock
E. Eric Swayze	EVP Research		01 Oct 2025	12,972	37,302 (0%)	0%	66.2	859,082	Common Stock
Wender Joseph H.	Director	Sale of securities on an exchange or to another person at price $ 65.50 per share.	01 Oct 2025	16,800	92,035 (0%)	0%	65.5	1,100,385	Common Stock
Swayze Eric E.	EVP Research		01 Oct 2025	12,972	50,274 (0%)	0%	53.8	697,504	Common Stock
E. Eric Swayze	EVP Research		01 Oct 2025	14,142	51,444 (0%)	0%	53.8	760,415	Common Stock
Swayze Eric E.	EVP Research		01 Oct 2025	14,142	12,972	-		-	Non-Qualified Stock Option (right to buy)
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share.	30 Sep 2025	57,900	137,557 (0%)	0%	53.8	3,113,283	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	30 Sep 2025	57,900	0	-		-	Non-Qualified Stock Option (right to buy)
Richard S. Geary	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 65.24 per share.	30 Sep 2025	57,900	79,657 (0%)	0%	65.2	3,777,668	Common Stock
Elizabeth L. Hougen	EVP, Finance & CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share.	30 Sep 2025	49,800	160,300 (0%)	0%	53.8	2,677,746	Common Stock
Elizabeth L. Hougen	EVP, Finance & CFO	Sale of securities on an exchange or to another person at price $ 65.26 per share.	30 Sep 2025	49,800	110,500 (0%)	0%	65.3	3,249,734	Common Stock
Elizabeth L. Hougen	EVP, Finance & CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	30 Sep 2025	49,800	0	-		-	Non-Qualified Stock Option (right to buy)
Patrick R. O'Neil	EVP CLO & General Counsel	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	29 Sep 2025	14,827	30,203	-		-	Non-Qualified Stock Option (right to buy)
Patrick R. O'Neil	EVP CLO & General Counsel	Sale of securities on an exchange or to another person at price $ 64.54 per share.	29 Sep 2025	10,473	57,130 (0%)	0%	64.5	675,945	Common Stock
Patrick R. O'Neil	EVP CLO & General Counsel	Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share.	29 Sep 2025	10,473	67,603 (0%)	0%	56.8	594,657	Common Stock
Patrick R. O'Neil	EVP CLO & General Counsel	Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share.	29 Sep 2025	14,827	71,957 (0%)	0%	56.8	841,877	Common Stock
Patrick R. O'Neil	EVP CLO & General Counsel	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	29 Sep 2025	10,473	45,030	-		-	Non-Qualified Stock Option (right to buy)
Patrick R. O'Neil	EVP CLO & General Counsel	Sale of securities on an exchange or to another person at price $ 64.68 per share.	29 Sep 2025	14,827	57,130 (0%)	0%	64.7	958,976	Common Stock
Patrick R. O'Neil	EVP CLO & General Counsel	Sale of securities on an exchange or to another person at price $ 64.58 per share.	12 Sep 2025	1,700	57,130 (0%)	0%	64.6	109,787	Common Stock
Patrick R. O'Neil	EVP CLO & General Counsel	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Sep 2025	1,700	55,503	-		-	Non-Qualified Stock Option (right to buy)
Patrick R. O'Neil	EVP CLO & General Counsel	Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share.	12 Sep 2025	1,700	58,830 (0%)	0%	56.8	96,526	Common Stock
Patrick R. O'Neil	EVP CLO & General Counsel	Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share.	09 Sep 2025	20,000	77,130 (0%)	0%	60.9	1,217,800	Common Stock
Patrick R. O'Neil	EVP CLO & General Counsel	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 Sep 2025	20,000	34,461	-		-	Non-Qualified Stock Option (right to buy)
Patrick R. O'Neil	EVP CLO & General Counsel	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 Sep 2025	1,000	57,203	-		-	Non-Qualified Stock Option (right to buy)
Patrick R. O'Neil	EVP CLO & General Counsel	Sale of securities on an exchange or to another person at price $ 64.56 per share.	09 Sep 2025	1,000	57,130 (0%)	0%	64.6	64,555	Common Stock
Patrick R. O'Neil	EVP CLO & General Counsel	Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share.	09 Sep 2025	1,000	58,130 (0%)	0%	56.8	56,780	Common Stock
Patrick R. O'Neil	EVP CLO & General Counsel	Sale of securities on an exchange or to another person at price $ 64.56 per share.	09 Sep 2025	20,000	57,130 (0%)	0%	64.6	1,291,106	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.80 per share.	09 Sep 2025	11,950	43,876 (0%)	0%	31.8	380,010	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Sale of securities on an exchange or to another person at price $ 62.16 per share.	09 Sep 2025	11,950	31,926 (0%)	0%	62.2	742,838	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 Sep 2025	11,950	41,700	-		-	Non-Qualified Stock Option (right to buy)
C. Frank Bennett	EVP, Chief Scientific Officer		05 Sep 2025	6,000	82,679 (0%)	0%	59.6	357,581	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.80 per share.	05 Sep 2025	250	32,176 (0%)	0%	31.8	7,950	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Sale of securities on an exchange or to another person at price $ 62.00 per share.	05 Sep 2025	250	31,926 (0%)	0%	62	15,500	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Sep 2025	250	53,650	-		-	Non-Qualified Stock Option (right to buy)
Joseph Klein	Director	Sale of securities on an exchange or to another person at price $ 60.00 per share.	03 Sep 2025	28,000	0 (0%)	0%	60	1,680,000	Common Stock
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Sep 2025	16,000	0	-		-	Non-Qualified Stock Option (right to buy)
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Sep 2025	12,000	0	-		-	Non-Qualified Stock Option (right to buy)
Joseph Klein	Director	Sale of securities on an exchange or to another person at price $ 60.00 per share.	03 Sep 2025	28,000	0 (0%)	0%	60	1,680,000	Common Stock
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Sep 2025	12,000	28,000 (0%)	0%		0	Common Stock
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Sep 2025	16,000	16,000 (0%)	0%		0	Common Stock
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Sep 2025	16,000	16,000 (0%)	0%		0	Common Stock
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Sep 2025	12,000	28,000 (0%)	0%		0	Common Stock
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Sep 2025	16,000	0	-		-	Non-Qualified Stock Option (right to buy)
Joseph Klein	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Sep 2025	12,000	0	-		-	Non-Qualified Stock Option (right to buy)
Joseph Loscalzo	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.42 per share.	03 Sep 2025	16,000	52,330 (0%)	0%	24.4	390,720	Common Stock
Joseph Loscalzo	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Sep 2025	16,000	0	-		-	Non-Qualified Stock Option (right to buy)
Joseph Loscalzo	Director	Sale of securities on an exchange or to another person at price $ 60.15 per share.	03 Sep 2025	16,000	36,330 (0%)	0%	60.1	962,371	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.58 per share.	03 Sep 2025	42,030	308,324 (0%)	0%	37.6	1,579,487	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share.	03 Sep 2025	102,900	282,909 (0%)	0%	53.8	5,532,933	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Sep 2025	102,900	0	-		-	Non-Qualified Stock Option (right to buy)
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Sep 2025	42,030	76,643	-		-	Non-Qualified Stock Option (right to buy)
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Sep 2025	27,568	40,173	-		-	Non-Qualified Stock Option (right to buy)
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Sep 2025	31,316	67,741	-		-	Non-Qualified Stock Option (right to buy)
Brett P. Monia	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 61.06 per share.	03 Sep 2025	59,699	180,009 (0%)	0%	61.1	3,645,394	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share.	03 Sep 2025	27,568	239,708 (0%)	0%	32.6	898,717	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share.	03 Sep 2025	31,316	212,140 (0%)	0%	32.6	1,020,902	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 60.13 per share.	03 Sep 2025	127,500	180,824 (0%)	0%	60.1	7,667,047	Common Stock
Brett P. Monia	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 59.12 per share.	03 Sep 2025	16,615	266,294 (0%)	0%	59.1	982,262	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Sep 2025	15,000	68,900	-		-	Non-Qualified Stock Option (right to buy)
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Sep 2025	15,000	53,900	-		-	Non-Qualified Stock Option (right to buy)
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.80 per share.	03 Sep 2025	2,800	34,726 (0%)	0%	31.8	89,040	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Sale of securities on an exchange or to another person at price $ 62.01 per share.	03 Sep 2025	2,800	31,926 (0%)	0%	62.0	173,628	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.80 per share.	03 Sep 2025	15,000	46,926 (0%)	0%	31.8	477,000	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Sale of securities on an exchange or to another person at price $ 59.09 per share.	03 Sep 2025	30,000	16,926 (0%)	0%	59.1	1,772,592	Common Stock
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Sep 2025	2,800	83,900	-		-	Non-Qualified Stock Option (right to buy)
Joseph T. Baroldi	EVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.80 per share.	03 Sep 2025	15,000	31,926 (0%)	0%	31.8	477,000	Common Stock
Eugene Schneider	EVP, Chf Clinical Develop Ofcr		03 Sep 2025	19,658	0	-		-	Non-Qualified Stock Option (right to buy)
Eugene Schneider	EVP, Chf Clinical Develop Ofcr		03 Sep 2025	7,203	51,507 (0%)	0%	61.4	442,382	Common Stock
Eugene Schneider	EVP, Chf Clinical Develop Ofcr		03 Sep 2025	12,455	58,710 (0%)	0%	60.5	753,039	Common Stock
Eugene Schneider	EVP, Chf Clinical Develop Ofcr		03 Sep 2025	19,658	71,165 (0%)	0%	53.8	1,057,011	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Sale of securities on an exchange or to another person at price $ 61.02 per share.	03 Sep 2025	3,162	15,009 (0%)	0%	61.0	192,943	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Sep 2025	928	13,440	-		-	Non-Qualified Stock Option (right to buy)
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Sep 2025	2,234	13,083	-		-	Non-Qualified Stock Option (right to buy)
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.58 per share.	03 Sep 2025	2,234	18,171 (0%)	0%	37.6	83,954	Common Stock
Shannon L. Devers	EVP, Chief Human Resources Ofc	Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share.	03 Sep 2025	928	15,937 (0%)	0%	32.6	30,253	Common Stock
B. Lynne Parshall	Director	Sale of securities on an exchange or to another person at price $ 50.42 per share.	02 Sep 2025	10,750	75,594 (0%)	0%	50.4	542,015	Common Stock
B. Lynne Parshall	Director	Sale of securities on an exchange or to another person at price $ 51.49 per share.	02 Sep 2025	9,250	66,344 (0%)	0%	51.5	476,283	Common Stock
Joseph H. Wender	Director	Sale of securities on an exchange or to another person at price $ 60.14 per share.	02 Sep 2025	11,200	108,835 (0%)	0%	60.1	673,549	Common Stock
Joseph H. Wender	Director	Sale of securities on an exchange or to another person at price $ 55.04 per share.	02 Sep 2025	11,200	125,635 (0%)	0%	55.0	616,432	Common Stock
Joseph H. Wender	Director	Sale of securities on an exchange or to another person at price $ 55.04 per share.	02 Sep 2025	11,200	125,635 (0%)	0%	55.0	616,432	Common Stock
Joseph H. Wender	Director	Sale of securities on an exchange or to another person at price $ 57.53 per share.	02 Sep 2025	5,600	120,035 (0%)	0%	57.5	322,174	Common Stock
Joseph H. Wender	Director	Sale of securities on an exchange or to another person at price $ 60.14 per share.	02 Sep 2025	11,200	108,835 (0%)	0%	60.1	673,549	Common Stock
Joseph H. Wender	Director	Sale of securities on an exchange or to another person at price $ 57.53 per share.	02 Sep 2025	5,600	120,035 (0%)	0%	57.5	322,174	Common Stock
Richard S. Geary	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 50.37 per share.	02 Sep 2025	10,000	79,657 (0%)	0%	50.4	503,671	Common Stock
C. Frank Bennett	EVP, Chief Scientific Officer		02 Sep 2025	46,800	135,479 (0%)	0%	53.8	2,516,436	Common Stock
C. Frank Bennett	EVP, Chief Scientific Officer		02 Sep 2025	5,000	88,679 (0%)	0%	49.1	245,700	Common Stock

*All Values are in $ Million

Client Category: Promoter/ KMP/ Director / Immediate Relatives / Employee / etc
Security Type: Share/ Warrants / Convertible Debentures

Data as reported to USA Exchanges

View All The Insider Trades disclosures

33.03% Fall from 52W High

Insider Trading disclosures for Ionis Pharma Inc

The latest disclosure was made by C. Frank Bennett in Ionis Pharma Inc where a trade of 110 Common Stock done at an average price of $51.3 was reported to US exchanges on Aug. 31, 2026.

Screeners based on Insider Trading and SAST parameters