Insider Trading disclosures for Madrigal Pharma Inc

The latest disclosure was made by Mr. William John Sibold in Madrigal Pharma Inc where a trade of 131 Common Stock done at an average price of $527.9 was reported to US exchanges on Sept. 9, 2026.

Insider trading is the trading of a company’s securities by individuals with access to confidential or material non-public information about the company. A company is required to report trading by corporate officers, directors, or other company members with significant access to privileged information to the Securities and Exchange Commission (SEC).

Client Name	Client Category	Action	Reported to Exchange	Quantity	Post Transaction Holding	Traded %	Avg. Price	Value	Security Type
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 527.88 per share.	09 Sep 2026	131	209,198 (1%)	0%	527.9	69,152	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 546.38 per share.	09 Sep 2026	120	197,746 (1%)	0%	546.4	65,565	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 544.83 per share.	09 Sep 2026	761	197,866 (1%)	0%	544.8	414,616	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 544.02 per share.	09 Sep 2026	1,539	198,627 (1%)	0%	544.0	837,253	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 542.60 per share.	09 Sep 2026	1,202	200,166 (1%)	0%	542.6	652,209	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 541.64 per share.	09 Sep 2026	368	201,368 (1%)	0%	541.6	199,324	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 540.59 per share.	09 Sep 2026	687	201,736 (1%)	0%	540.6	371,382	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 537.62 per share.	09 Sep 2026	160	202,423 (1%)	0%	537.6	86,019	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 535.94 per share.	09 Sep 2026	218	202,583 (1%)	0%	535.9	116,836	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 534.07 per share.	09 Sep 2026	106	202,801 (1%)	0%	534.1	56,611	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 533.08 per share.	09 Sep 2026	60	202,907 (1%)	0%	533.1	31,985	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 542.55 per share.	09 Sep 2026	160	202,967 (1%)	0%	542.6	86,808	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 541.65 per share.	09 Sep 2026	362	203,127 (1%)	0%	541.7	196,079	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 540.19 per share.	09 Sep 2026	505	203,489 (1%)	0%	540.2	272,796	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 539.03 per share.	09 Sep 2026	215	203,994 (1%)	0%	539.0	115,891	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 538.30 per share.	09 Sep 2026	520	204,209 (1%)	0%	538.3	279,914	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 537.17 per share.	09 Sep 2026	640	204,729 (1%)	0%	537.2	343,791	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 536.11 per share.	09 Sep 2026	1,040	205,369 (1%)	0%	536.1	557,557	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 535.27 per share.	09 Sep 2026	644	206,409 (1%)	0%	535.3	344,715	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 534.20 per share.	09 Sep 2026	396	207,053 (1%)	0%	534.2	211,542	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 533.09 per share.	09 Sep 2026	512	207,449 (1%)	0%	533.1	272,944	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 531.99 per share.	09 Sep 2026	368	207,961 (1%)	0%	532.0	195,772	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 530.23 per share.	09 Sep 2026	522	208,329 (1%)	0%	530.2	276,781	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 529.27 per share.	09 Sep 2026	347	208,851 (1%)	0%	529.3	183,656	Common Stock
Ms. Shannon T. Kelley	General Counsel	Sale of securities on an exchange or to another person at price $ 514.97 per share.	17 Aug 2026	664	11,474 (0%)	0%	515.0	341,940	Common Stock
Dr. John C. Reed,M.D.,PhD	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Aug 2026	647	647 (0%)	0%		0	Common Stock
Dr. John C. Reed,M.D.,PhD	Director		15 Aug 2026	1,078	1,078	-		-	Stock Option (Right to Buy)
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 548.87 per share.	17 Jul 2026	47	209,763 (1%)	0%	548.9	25,797	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 547.70 per share.	17 Jul 2026	680	209,810 (1%)	0%	547.7	372,435	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 547.08 per share.	17 Jul 2026	269	210,490 (1%)	0%	547.1	147,164	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 545.71 per share.	17 Jul 2026	275	210,759 (1%)	0%	545.7	150,070	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 544.71 per share.	17 Jul 2026	545	211,034 (1%)	0%	544.7	296,869	Common Stock
Mr. William John Sibold	Director, President and CEO		17 Jul 2026	50,000	0	-		-	Performance Restricted Stock Units
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 543.79 per share.	17 Jul 2026	110	211,579 (1%)	0%	543.8	59,817	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 542.74 per share.	17 Jul 2026	140	211,689 (1%)	0%	542.7	75,984	Common Stock
Mr. William John Sibold	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	17 Jul 2026	50,000	211,829 (1%)	0%		-	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 550.01 per share.	17 Jul 2026	153	209,610 (1%)	0%	550.0	84,152	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 551.00 per share.	17 Jul 2026	1	209,609 (1%)	0%	551	551	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 555.05 per share.	17 Jul 2026	280	209,329 (1%)	0%	555.1	155,414	Common Stock
Dr. Jacqualyn A. Fouse, PhD	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	17 Jun 2026	454	1,551 (0%)	0%		0	Common Stock
Dr. Jacqualyn A. Fouse, PhD	Director		17 Jun 2026	766	766	-		-	Stock Option (Right to Buy)
Dr. Rebecca A. Taub,M.D.	Director		17 Jun 2026	766	766	-		-	Stock Option (Right to Buy)
Dr. Rebecca A. Taub,M.D.	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	17 Jun 2026	454	452,667 (2%)	0%		0	Common Stock
Dr. Richard S. Levy,M.D.	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	17 Jun 2026	454	22,469 (0%)	0%		0	Common Stock
Dr. Richard S. Levy,M.D.	Director		17 Jun 2026	766	766	-		-	Stock Option (Right to Buy)
Mr. Daniel J. Brennan	Director		17 Jun 2026	681	681	-		-	Stock Option (Right to Buy)
Mr. Daniel J. Brennan	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	17 Jun 2026	404	1,371 (0%)	0%		0	Common Stock
Mr. James M. Daly	Director		17 Jun 2026	766	766	-		-	Stock Option (Right to Buy)
Mr. James M. Daly	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	17 Jun 2026	454	3,081 (0%)	0%		0	Common Stock
Dr. David Soergel, M.D.	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 495.74 per share.	01 Jun 2026	1,042	10,033 (0%)	0%	495.7	516,561	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 506.68 per share.	22 May 2026	40	27,657 (0%)	0%	506.7	20,267	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 518.76 per share.	22 May 2026	782	22,095 (0%)	0%	518.8	405,669	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 519.98 per share.	22 May 2026	80	22,015 (0%)	0%	520.0	41,598	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 517.59 per share.	22 May 2026	1,497	22,877 (0%)	0%	517.6	774,835	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 516.87 per share.	22 May 2026	723	24,374 (0%)	0%	516.9	373,694	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 515.92 per share.	22 May 2026	657	25,097 (0%)	0%	515.9	338,961	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 514.67 per share.	22 May 2026	343	25,754 (0%)	0%	514.7	176,532	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 512.98 per share.	22 May 2026	40	26,097 (0%)	0%	513.0	20,519	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 512.50 per share.	22 May 2026	439	26,137 (0%)	0%	512.5	224,988	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 511.40 per share.	22 May 2026	610	26,576 (0%)	0%	511.4	311,952	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 510.36 per share.	22 May 2026	151	27,186 (0%)	0%	510.4	77,064	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 508.24 per share.	22 May 2026	320	27,337 (0%)	0%	508.2	162,637	Common Stock
Dr. David Soergel, M.D.	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 515.90 per share.	18 May 2026	844	11,075 (0%)	0%	515.9	435,420	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 431.94 per share.	06 Mar 2026	491	452,213 (2%)	0%	431.9	212,083	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 431.94 per share.	06 Mar 2026	491	452,213 (2%)	0%	431.9	212,083	-
Mr. William John Sibold	Director, President and CEO		04 Mar 2026	18,743	18,743	-		-	Stock Option (Right to Buy)
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 431.94 per share.	04 Mar 2026	1,663	161,829 (1%)	0%	431.9	718,316	Common Stock
Mr. William John Sibold	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	04 Mar 2026	14,995	163,492 (1%)	0%		0	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 431.94 per share.	04 Mar 2026	646	13,826 (0%)	0%	431.9	279,033	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	04 Mar 2026	5,215	14,472 (0%)	0%		0	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 429.58 per share.	04 Mar 2026	40	13,086 (0%)	0%	429.6	17,183	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 428.99 per share.	04 Mar 2026	160	13,126 (0%)	0%	429.0	68,639	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 427.85 per share.	04 Mar 2026	80	13,286 (0%)	0%	427.9	34,228	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 426.86 per share.	04 Mar 2026	420	13,366 (0%)	0%	426.9	179,283	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 425.08 per share.	04 Mar 2026	40	13,786 (0%)	0%	425.1	17,003	Common Stock
Ms. Mardi C. Dier	EVP and CFO		04 Mar 2026	6,519	6,519	-		-	Stock Option (Right to Buy)
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 437.65 per share.	04 Mar 2026	40	12,490 (0%)	0%	437.7	17,506	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 436.69 per share.	04 Mar 2026	80	12,530 (0%)	0%	436.7	34,935	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 435.31 per share.	04 Mar 2026	80	12,610 (0%)	0%	435.3	34,825	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 434.20 per share.	04 Mar 2026	160	12,690 (0%)	0%	434.2	69,472	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 432.55 per share.	04 Mar 2026	116	12,850 (0%)	0%	432.6	50,176	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 430.90 per share.	04 Mar 2026	120	12,966 (0%)	0%	430.9	51,708	Common Stock
Dr. David Soergel, M.D.	Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	04 Mar 2026	4,374	11,919 (0%)	0%		0	Common Stock
Dr. David Soergel, M.D.	Chief Medical Officer		04 Mar 2026	5,467	5,467	-		-	Stock Option (Right to Buy)
Ms. Carole Huntsman	Chief Commercial Officer		04 Mar 2026	4,986	4,986	-		-	Stock Option (Right to Buy)
Ms. Carole Huntsman	Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	04 Mar 2026	3,989	13,111 (0%)	0%		0	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 431.94 per share.	04 Mar 2026	419	12,692 (0%)	0%	431.9	180,983	Common Stock
Ms. Shannon T. Kelley	General Counsel		04 Mar 2026	5,022	5,022	-		-	Stock Option (Right to Buy)
Ms. Shannon T. Kelley	General Counsel	Grant, award, or other acquisition of securities at price $ 0.00 per share.	04 Mar 2026	4,017	12,498 (0%)	0%		0	Common Stock
Ms. Shannon T. Kelley	General Counsel	Sale of securities on an exchange or to another person at price $ 431.94 per share.	04 Mar 2026	360	12,138 (0%)	0%	431.9	155,498	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 427.21 per share.	02 Mar 2026	1,183	9,257 (0%)	0%	427.2	505,389	Common Stock
Dr. Richard S. Levy,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.36 per share.	23 Feb 2026	2,500	27,697 (0%)	0%	7.4	18,400	Common Stock
Dr. Richard S. Levy,M.D.	Director		23 Feb 2026	2,500	0	-		-	Stock Option (Right to Buy)
Dr. Richard S. Levy,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.36 per share.	23 Feb 2026	2,500	27,697 (0%)	0%	7.4	18,400	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 492.42 per share.	26 Jan 2026	647	452,704 (2%)	0%	492.4	318,596	Common Stock
Dr. Richard S. Levy,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.46 per share.	26 Jan 2026	4,000	25,197 (0%)	0%	16.5	65,840	Common Stock
Dr. Richard S. Levy,M.D.	Director		26 Jan 2026	4,000	0	-		-	Stock Option (Right to Buy)
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 492.42 per share.	26 Jan 2026	1,577	148,497 (0%)	0%	492.4	776,546	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 494.59 per share.	26 Jan 2026	570	9,122 (0%)	0%	494.6	281,916	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 492.42 per share.	26 Jan 2026	340	9,692 (0%)	0%	492.4	167,423	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 492.42 per share.	26 Jan 2026	647	452,704 (2%)	0%	492.4	318,596	-
Dr. Richard S. Levy,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.46 per share.	26 Jan 2026	4,000	25,197 (0%)	0%	16.5	65,840	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 490.77 per share.	20 Jan 2026	2,238	453,351 (2%)	0%	490.8	1,098,343	Common Stock
Ms. Shannon T. Kelley	General Counsel	Sale of securities on an exchange or to another person at price $ 501.40 per share.	20 Jan 2026	429	8,481 (0%)	0%	501.4	215,101	Common Stock
Ms. Shannon T. Kelley	General Counsel	Sale of securities on an exchange or to another person at price $ 490.77 per share.	20 Jan 2026	263	8,910 (0%)	0%	490.8	129,073	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 490.77 per share.	20 Jan 2026	2,238	453,351 (2%)	0%	490.8	1,098,343	-
Ms. Rita Thakkar	Chief Accounting Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jan 2026	2,398	2,398 (0%)	0%		0	Common Stock
Ms. Rita Thakkar	Chief Accounting Officer		15 Jan 2026	1,826	1,826	-		-	Stock Option (Right to Buy)
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 528.18 per share.	09 Jan 2026	575	191,021 (1%)	0%	528.2	303,702	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 529.16 per share.	09 Jan 2026	691	190,330 (1%)	0%	529.2	365,653	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 529.77 per share.	09 Jan 2026	166	190,164 (1%)	0%	529.8	87,941	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 530.69 per share.	09 Jan 2026	280	189,884 (1%)	0%	530.7	148,592	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 532.50 per share.	09 Jan 2026	80	189,804 (1%)	0%	532.5	42,600	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 534.16 per share.	09 Jan 2026	332	189,472 (1%)	0%	534.2	177,342	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 535.29 per share.	09 Jan 2026	148	189,324 (1%)	0%	535.3	79,223	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 536.02 per share.	09 Jan 2026	473	188,851 (1%)	0%	536.0	253,538	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 536.88 per share.	09 Jan 2026	487	188,364 (1%)	0%	536.9	261,459	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 537.85 per share.	09 Jan 2026	80	188,284 (1%)	0%	537.9	43,028	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 539.23 per share.	09 Jan 2026	480	187,804 (1%)	0%	539.2	258,831	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 540.36 per share.	09 Jan 2026	600	187,204 (1%)	0%	540.4	324,215	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 545.80 per share.	09 Jan 2026	40	187,164 (1%)	0%	545.8	21,832	Common Stock
Dr. Paul A. Friedman,M.D.	Director		09 Jan 2026	24,520	280	-		-	Stock Option (Right to Buy)
Dr. Rebecca A. Taub,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.80 per share.	09 Jan 2026	18,410	473,999 (3%)	0%	15.8	290,878	Common Stock
Dr. Rebecca A. Taub,M.D.	Director		09 Jan 2026	240	0	-		-	Stock Option (Right to Buy)
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 512.02 per share.	09 Jan 2026	960	473,039 (3%)	0%	512.0	491,537	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 513.12 per share.	09 Jan 2026	960	472,079 (3%)	0%	513.1	492,595	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 514.63 per share.	09 Jan 2026	937	471,142 (3%)	0%	514.6	482,207	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 515.82 per share.	09 Jan 2026	1,578	469,564 (3%)	0%	515.8	813,968	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 516.81 per share.	09 Jan 2026	521	469,043 (3%)	0%	516.8	269,257	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 517.84 per share.	09 Jan 2026	2,044	466,999 (3%)	0%	517.8	1,058,468	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 518.67 per share.	09 Jan 2026	970	466,029 (3%)	0%	518.7	503,106	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 519.89 per share.	09 Jan 2026	539	465,490 (3%)	0%	519.9	280,220	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 521.11 per share.	09 Jan 2026	440	465,050 (3%)	0%	521.1	229,289	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 521.95 per share.	09 Jan 2026	588	464,462 (3%)	0%	522.0	306,909	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 522.98 per share.	09 Jan 2026	732	463,730 (3%)	0%	523.0	382,823	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 524.06 per share.	09 Jan 2026	1,335	462,395 (2%)	0%	524.1	699,623	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 525.12 per share.	09 Jan 2026	1,489	460,906 (2%)	0%	525.1	781,903	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 526.05 per share.	09 Jan 2026	913	459,993 (2%)	0%	526.0	480,281	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 526.95 per share.	09 Jan 2026	1,135	458,858 (2%)	0%	527.0	598,091	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 528.16 per share.	09 Jan 2026	465	458,393 (2%)	0%	528.2	245,593	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 529.28 per share.	09 Jan 2026	554	457,839 (2%)	0%	529.3	293,222	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 530.45 per share.	09 Jan 2026	256	457,583 (2%)	0%	530.5	135,796	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 531.07 per share.	09 Jan 2026	30	457,553 (2%)	0%	531.1	15,932	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 532.50 per share.	09 Jan 2026	40	457,513 (2%)	0%	532.5	21,300	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 534.17 per share.	09 Jan 2026	271	457,242 (2%)	0%	534.2	144,761	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 534.93 per share.	09 Jan 2026	89	457,153 (2%)	0%	534.9	47,609	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 535.80 per share.	09 Jan 2026	299	456,854 (2%)	0%	535.8	160,205	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 536.88 per share.	09 Jan 2026	385	456,469 (2%)	0%	536.9	206,700	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 537.85 per share.	09 Jan 2026	40	456,429 (2%)	0%	537.9	21,514	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 539.26 per share.	09 Jan 2026	400	456,029 (2%)	0%	539.3	215,706	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 540.25 per share.	09 Jan 2026	40	455,989 (2%)	0%	540.3	21,610	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 542.72 per share.	09 Jan 2026	400	455,589 (2%)	0%	542.7	217,088	Common Stock
Dr. Rebecca A. Taub,M.D.	Director		09 Jan 2026	18,410	240	-		-	Stock Option (Right to Buy)
Dr. Rebecca A. Taub,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.80 per share.	09 Jan 2026	240	455,829 (2%)	0%	15.8	3,792	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 545.80 per share.	09 Jan 2026	40	455,789 (2%)	0%	545.8	21,832	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 551.24 per share.	09 Jan 2026	200	455,589 (2%)	0%	551.2	110,248	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.80 per share.	09 Jan 2026	18,410	473,999 (3%)	0%	15.8	290,878	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 512.02 per share.	09 Jan 2026	960	473,039 (3%)	0%	512.0	491,537	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 513.12 per share.	09 Jan 2026	960	472,079 (3%)	0%	513.1	492,595	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 514.63 per share.	09 Jan 2026	937	471,142 (3%)	0%	514.6	482,207	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 515.82 per share.	09 Jan 2026	1,578	469,564 (3%)	0%	515.8	813,968	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 516.81 per share.	09 Jan 2026	521	469,043 (3%)	0%	516.8	269,257	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 517.84 per share.	09 Jan 2026	2,044	466,999 (3%)	0%	517.8	1,058,468	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 518.67 per share.	09 Jan 2026	970	466,029 (3%)	0%	518.7	503,106	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 519.89 per share.	09 Jan 2026	539	465,490 (3%)	0%	519.9	280,220	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 521.11 per share.	09 Jan 2026	440	465,050 (3%)	0%	521.1	229,289	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 521.95 per share.	09 Jan 2026	588	464,462 (3%)	0%	522.0	306,909	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 522.98 per share.	09 Jan 2026	732	463,730 (3%)	0%	523.0	382,823	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 524.06 per share.	09 Jan 2026	1,335	462,395 (2%)	0%	524.1	699,623	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 525.12 per share.	09 Jan 2026	1,489	460,906 (2%)	0%	525.1	781,903	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 526.05 per share.	09 Jan 2026	913	459,993 (2%)	0%	526.0	480,281	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 526.95 per share.	09 Jan 2026	1,135	458,858 (2%)	0%	527.0	598,091	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 528.16 per share.	09 Jan 2026	465	458,393 (2%)	0%	528.2	245,593	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 529.28 per share.	09 Jan 2026	554	457,839 (2%)	0%	529.3	293,222	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 530.45 per share.	09 Jan 2026	256	457,583 (2%)	0%	530.5	135,796	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 531.07 per share.	09 Jan 2026	30	457,553 (2%)	0%	531.1	15,932	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 532.50 per share.	09 Jan 2026	40	457,513 (2%)	0%	532.5	21,300	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 534.17 per share.	09 Jan 2026	271	457,242 (2%)	0%	534.2	144,761	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 534.93 per share.	09 Jan 2026	89	457,153 (2%)	0%	534.9	47,609	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 535.80 per share.	09 Jan 2026	299	456,854 (2%)	0%	535.8	160,205	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 536.88 per share.	09 Jan 2026	385	456,469 (2%)	0%	536.9	206,700	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 537.85 per share.	09 Jan 2026	40	456,429 (2%)	0%	537.9	21,514	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 539.26 per share.	09 Jan 2026	400	456,029 (2%)	0%	539.3	215,706	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 540.25 per share.	09 Jan 2026	40	455,989 (2%)	0%	540.3	21,610	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 542.72 per share.	09 Jan 2026	400	455,589 (2%)	0%	542.7	217,088	-
Dr. Rebecca A. Taub,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.80 per share.	09 Jan 2026	240	455,829 (2%)	0%	15.8	3,792	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 545.80 per share.	09 Jan 2026	40	455,789 (2%)	0%	545.8	21,832	-
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 551.24 per share.	09 Jan 2026	200	455,589 (2%)	0%	551.2	110,248	-
Dr. Paul A. Friedman,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.80 per share.	09 Jan 2026	280	187,444 (1%)	0%	15.8	4,424	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 551.24 per share.	09 Jan 2026	280	187,164 (1%)	0%	551.2	154,348	-
Dr. Paul A. Friedman,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.80 per share.	09 Jan 2026	24,520	211,684 (1%)	0%	15.8	387,416	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 511.98 per share.	09 Jan 2026	1,480	210,204 (1%)	0%	512.0	757,727	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 513.11 per share.	09 Jan 2026	1,094	209,110 (1%)	0%	513.1	561,340	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 514.68 per share.	09 Jan 2026	1,345	207,765 (1%)	0%	514.7	692,246	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 515.81 per share.	09 Jan 2026	1,996	205,769 (1%)	0%	515.8	1,029,561	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 516.84 per share.	09 Jan 2026	766	205,003 (1%)	0%	516.8	395,896	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 517.86 per share.	09 Jan 2026	2,450	202,553 (1%)	0%	517.9	1,268,755	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 518.68 per share.	09 Jan 2026	1,363	201,190 (1%)	0%	518.7	706,966	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 519.88 per share.	09 Jan 2026	846	200,344 (1%)	0%	519.9	439,822	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 521.03 per share.	09 Jan 2026	681	199,663 (1%)	0%	521.0	354,823	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 521.98 per share.	09 Jan 2026	840	198,823 (1%)	0%	522.0	438,461	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 523.00 per share.	09 Jan 2026	970	197,853 (1%)	0%	523.0	507,307	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 524.10 per share.	09 Jan 2026	1,199	196,654 (1%)	0%	524.1	628,394	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 525.05 per share.	09 Jan 2026	2,432	194,222 (1%)	0%	525.0	1,276,916	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 526.00 per share.	09 Jan 2026	1,066	193,156 (1%)	0%	526.0	560,717	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 526.97 per share.	09 Jan 2026	1,560	191,596 (1%)	0%	527.0	822,071	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 528.18 per share.	09 Jan 2026	575	191,021 (1%)	0%	528.2	303,702	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 529.16 per share.	09 Jan 2026	691	190,330 (1%)	0%	529.2	365,653	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 529.77 per share.	09 Jan 2026	166	190,164 (1%)	0%	529.8	87,941	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 530.69 per share.	09 Jan 2026	280	189,884 (1%)	0%	530.7	148,592	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 532.50 per share.	09 Jan 2026	80	189,804 (1%)	0%	532.5	42,600	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 534.16 per share.	09 Jan 2026	332	189,472 (1%)	0%	534.2	177,342	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 535.29 per share.	09 Jan 2026	148	189,324 (1%)	0%	535.3	79,223	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 536.02 per share.	09 Jan 2026	473	188,851 (1%)	0%	536.0	253,538	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 536.88 per share.	09 Jan 2026	487	188,364 (1%)	0%	536.9	261,459	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 537.85 per share.	09 Jan 2026	80	188,284 (1%)	0%	537.9	43,028	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 539.23 per share.	09 Jan 2026	480	187,804 (1%)	0%	539.2	258,831	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 540.36 per share.	09 Jan 2026	600	187,204 (1%)	0%	540.4	324,215	-
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 545.80 per share.	09 Jan 2026	40	187,164 (1%)	0%	545.8	21,832	-
Dr. Paul A. Friedman,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.80 per share.	09 Jan 2026	280	187,444 (1%)	0%	15.8	4,424	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 551.24 per share.	09 Jan 2026	280	187,164 (1%)	0%	551.2	154,348	Common Stock
Dr. Paul A. Friedman,M.D.	Director		09 Jan 2026	280	0	-		-	Stock Option (Right to Buy)
Dr. Paul A. Friedman,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.80 per share.	09 Jan 2026	24,520	211,684 (1%)	0%	15.8	387,416	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 511.98 per share.	09 Jan 2026	1,480	210,204 (1%)	0%	512.0	757,727	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 513.11 per share.	09 Jan 2026	1,094	209,110 (1%)	0%	513.1	561,340	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 514.68 per share.	09 Jan 2026	1,345	207,765 (1%)	0%	514.7	692,246	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 515.81 per share.	09 Jan 2026	1,996	205,769 (1%)	0%	515.8	1,029,561	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 516.84 per share.	09 Jan 2026	766	205,003 (1%)	0%	516.8	395,896	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 517.86 per share.	09 Jan 2026	2,450	202,553 (1%)	0%	517.9	1,268,755	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 518.68 per share.	09 Jan 2026	1,363	201,190 (1%)	0%	518.7	706,966	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 519.88 per share.	09 Jan 2026	846	200,344 (1%)	0%	519.9	439,822	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 521.03 per share.	09 Jan 2026	681	199,663 (1%)	0%	521.0	354,823	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 521.98 per share.	09 Jan 2026	840	198,823 (1%)	0%	522.0	438,461	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 523.00 per share.	09 Jan 2026	970	197,853 (1%)	0%	523.0	507,307	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 524.10 per share.	09 Jan 2026	1,199	196,654 (1%)	0%	524.1	628,394	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 525.05 per share.	09 Jan 2026	2,432	194,222 (1%)	0%	525.0	1,276,916	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 526.00 per share.	09 Jan 2026	1,066	193,156 (1%)	0%	526.0	560,717	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 526.97 per share.	09 Jan 2026	1,560	191,596 (1%)	0%	527.0	822,071	Common Stock
Dr. Paul A. Friedman,M.D.	Director		10 Dec 2025	24,800	24,800	-		-	Stock Option (Right to Buy)
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 555.39 per share.	10 Dec 2025	160	187,164 (1%)	0%	555.4	88,862	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 555.00 per share.	10 Dec 2025	1,029	187,324 (1%)	0%	555.0	571,091	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 553.83 per share.	10 Dec 2025	5,001	188,353 (1%)	0%	553.8	2,769,728	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 552.74 per share.	10 Dec 2025	5,533	193,354 (1%)	0%	552.7	3,058,332	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 551.67 per share.	10 Dec 2025	7,193	198,887 (1%)	0%	551.7	3,968,129	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 550.93 per share.	10 Dec 2025	4,316	206,080 (1%)	0%	550.9	2,377,826	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 549.99 per share.	10 Dec 2025	409	210,396 (1%)	0%	550.0	224,945	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 548.51 per share.	10 Dec 2025	535	210,805 (1%)	0%	548.5	293,451	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 547.75 per share.	10 Dec 2025	624	211,340 (1%)	0%	547.7	341,794	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.80 per share.	10 Dec 2025	24,800	211,964 (1%)	0%	15.8	391,840	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.80 per share.	10 Dec 2025	18,650	479,694 (3%)	0%	15.8	294,670	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 547.76 per share.	10 Dec 2025	491	479,203 (3%)	0%	547.8	268,949	Common Stock
Dr. Rebecca A. Taub,M.D.	Director		10 Dec 2025	18,650	18,650	-		-	Stock Option (Right to Buy)
Dr. Rebecca A. Taub,M.D.	Director	Gift of securities by or to the insider at price $ 0.00 per share.	10 Dec 2025	5,455	455,589 (2%)	0%		0	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 555.39 per share.	10 Dec 2025	200	461,044 (2%)	0%	555.4	111,078	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 554.84 per share.	10 Dec 2025	1,027	461,244 (2%)	0%	554.8	569,822	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 553.88 per share.	10 Dec 2025	3,087	462,271 (2%)	0%	553.9	1,709,826	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 552.81 per share.	10 Dec 2025	3,857	465,358 (3%)	0%	552.8	2,132,197	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 551.85 per share.	10 Dec 2025	4,410	469,215 (3%)	0%	551.8	2,433,641	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 550.99 per share.	10 Dec 2025	4,723	473,625 (3%)	0%	551.0	2,602,307	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 550.07 per share.	10 Dec 2025	486	478,348 (3%)	0%	550.1	267,335	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 548.56 per share.	10 Dec 2025	369	478,834 (3%)	0%	548.6	202,418	Common Stock
Mr. William John Sibold	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Dec 2025	50,000	152,474 (0%)	0%		-	Common Stock
Mr. William John Sibold	Director, President and CEO		03 Dec 2025	50,000	0	-		-	Performance Restricted Stock Units
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 575.34 per share.	03 Dec 2025	2,400	150,074 (0%)	0%	575.3	1,380,816	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 251.63 per share.	02 Dec 2025	4,173	14,613 (0%)	0%	251.6	1,050,052	Common Stock
Ms. Mardi C. Dier	EVP and CFO		02 Dec 2025	4,173	9,180	-		-	Stock Option (Right to Buy)
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 596.19 per share.	02 Dec 2025	80	10,440 (0%)	0%	596.2	47,695	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 595.20 per share.	02 Dec 2025	74	10,520 (0%)	0%	595.2	44,045	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 590.38 per share.	02 Dec 2025	160	10,594 (0%)	0%	590.4	94,460	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 589.65 per share.	02 Dec 2025	160	10,754 (0%)	0%	589.7	94,344	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 587.85 per share.	02 Dec 2025	240	10,914 (0%)	0%	587.9	141,084	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 585.44 per share.	02 Dec 2025	240	11,154 (0%)	0%	585.4	140,505	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 579.85 per share.	02 Dec 2025	480	11,394 (0%)	0%	579.9	278,329	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 578.83 per share.	02 Dec 2025	258	11,874 (0%)	0%	578.8	149,338	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 577.82 per share.	02 Dec 2025	320	12,132 (0%)	0%	577.8	184,901	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 576.15 per share.	02 Dec 2025	240	12,452 (0%)	0%	576.2	138,276	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 574.95 per share.	02 Dec 2025	120	12,692 (0%)	0%	575.0	68,994	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 574.00 per share.	02 Dec 2025	717	12,812 (0%)	0%	574.0	411,559	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 573.01 per share.	02 Dec 2025	354	13,529 (0%)	0%	573.0	202,847	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 571.99 per share.	02 Dec 2025	410	13,883 (0%)	0%	572.0	234,516	Common Stock
Ms. Mardi C. Dier	EVP and CFO	Sale of securities on an exchange or to another person at price $ 570.39 per share.	02 Dec 2025	320	14,293 (0%)	0%	570.4	182,524	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 550.97 per share.	21 Nov 2025	894	11,096 (0%)	0%	551.0	492,567	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 563.20 per share.	21 Nov 2025	40	10,112 (0%)	0%	563.2	22,528	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 560.62 per share.	21 Nov 2025	80	10,152 (0%)	0%	560.6	44,850	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 559.60 per share.	21 Nov 2025	200	10,232 (0%)	0%	559.6	111,920	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 556.04 per share.	21 Nov 2025	120	10,432 (0%)	0%	556.0	66,725	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 553.22 per share.	21 Nov 2025	40	10,552 (0%)	0%	553.2	22,129	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 552.38 per share.	21 Nov 2025	200	10,592 (0%)	0%	552.4	110,477	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 564.56 per share.	21 Nov 2025	80	10,032 (0%)	0%	564.6	45,165	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 549.35 per share.	21 Nov 2025	40	10,792 (0%)	0%	549.4	21,974	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 548.71 per share.	21 Nov 2025	120	10,832 (0%)	0%	548.7	65,845	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 547.27 per share.	21 Nov 2025	144	10,952 (0%)	0%	547.3	78,807	Common Stock
Dr. Richard S. Levy,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.36 per share.	13 Nov 2025	2,500	23,697 (0%)	0%	7.4	18,400	Common Stock
Dr. Richard S. Levy,M.D.	Director		13 Nov 2025	6,000	4,000	-		-	Stock Option (Right to Buy)
Dr. Richard S. Levy,M.D.	Director		13 Nov 2025	2,500	2,500	-		-	Stock Option (Right to Buy)
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 530.20 per share.	13 Nov 2025	40	21,197 (0%)	0%	530.2	21,208	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 528.60 per share.	13 Nov 2025	440	21,237 (0%)	0%	528.6	232,586	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 527.85 per share.	13 Nov 2025	200	21,677 (0%)	0%	527.9	105,570	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 526.68 per share.	13 Nov 2025	120	21,877 (0%)	0%	526.7	63,202	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 524.49 per share.	13 Nov 2025	153	21,997 (0%)	0%	524.5	80,247	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 523.66 per share.	13 Nov 2025	811	22,150 (0%)	0%	523.7	424,687	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 522.70 per share.	13 Nov 2025	1,434	22,961 (0%)	0%	522.7	749,557	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 521.79 per share.	13 Nov 2025	1,094	24,395 (0%)	0%	521.8	570,836	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 520.68 per share.	13 Nov 2025	308	25,489 (0%)	0%	520.7	160,369	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 519.67 per share.	13 Nov 2025	1,355	25,797 (0%)	0%	519.7	704,147	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 518.53 per share.	13 Nov 2025	835	27,152 (0%)	0%	518.5	432,974	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 517.51 per share.	13 Nov 2025	645	27,987 (0%)	0%	517.5	333,796	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 515.64 per share.	13 Nov 2025	919	28,632 (0%)	0%	515.6	473,876	Common Stock
Dr. Richard S. Levy,M.D.	Director	Sale of securities on an exchange or to another person at price $ 514.67 per share.	13 Nov 2025	146	29,551 (0%)	0%	514.7	75,142	Common Stock
Dr. Richard S. Levy,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.46 per share.	13 Nov 2025	6,000	29,697 (0%)	0%	16.5	98,760	Common Stock
Mr. Kenneth M. Bate	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.45 per share.	05 Nov 2025	5,470	8,097 (0%)	0%	9.5	51,692	Common Stock
Mr. Kenneth M. Bate	Director		05 Nov 2025	1,105	0	-		-	Stock Option (Right to Buy)
Mr. Kenneth M. Bate	Director		05 Nov 2025	10,000	0	-		-	Stock Option (Right to Buy)
Mr. Kenneth M. Bate	Director		05 Nov 2025	5,470	0	-		-	Stock Option (Right to Buy)
Mr. Kenneth M. Bate	Director	Sale of securities on an exchange or to another person at price $ 490.97 per share.	05 Nov 2025	30	2,627 (0%)	0%	491.0	14,729	Common Stock
Mr. Kenneth M. Bate	Director	Sale of securities on an exchange or to another person at price $ 489.95 per share.	05 Nov 2025	933	2,657 (0%)	0%	489.9	457,119	Common Stock
Mr. Kenneth M. Bate	Director	Sale of securities on an exchange or to another person at price $ 489.09 per share.	05 Nov 2025	696	3,590 (0%)	0%	489.1	340,409	Common Stock
Mr. Kenneth M. Bate	Director	Sale of securities on an exchange or to another person at price $ 487.49 per share.	05 Nov 2025	2,775	4,286 (0%)	0%	487.5	1,352,796	Common Stock
Mr. Kenneth M. Bate	Director	Sale of securities on an exchange or to another person at price $ 486.74 per share.	05 Nov 2025	827	7,061 (0%)	0%	486.7	402,530	Common Stock
Mr. Kenneth M. Bate	Director	Sale of securities on an exchange or to another person at price $ 485.54 per share.	05 Nov 2025	1,008	7,888 (0%)	0%	485.5	489,421	Common Stock
Mr. Kenneth M. Bate	Director	Sale of securities on an exchange or to another person at price $ 484.78 per share.	05 Nov 2025	1,931	8,896 (0%)	0%	484.8	936,105	Common Stock
Mr. Kenneth M. Bate	Director	Sale of securities on an exchange or to another person at price $ 483.41 per share.	05 Nov 2025	2,069	10,827 (0%)	0%	483.4	1,000,170	Common Stock
Mr. Kenneth M. Bate	Director	Sale of securities on an exchange or to another person at price $ 482.41 per share.	05 Nov 2025	1,284	12,896 (0%)	0%	482.4	619,417	Common Stock
Mr. Kenneth M. Bate	Director	Sale of securities on an exchange or to another person at price $ 481.13 per share.	05 Nov 2025	3,259	14,180 (0%)	0%	481.1	1,567,995	Common Stock
Mr. Kenneth M. Bate	Director	Sale of securities on an exchange or to another person at price $ 480.24 per share.	05 Nov 2025	1,763	17,439 (0%)	0%	480.2	846,663	Common Stock
Mr. Kenneth M. Bate	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 280.04 per share.	05 Nov 2025	1,105	19,202 (0%)	0%	280.0	309,444	Common Stock
Mr. Kenneth M. Bate	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 303.79 per share.	05 Nov 2025	10,000	18,097 (0%)	0%	303.8	3,037,900	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 445.63 per share.	09 Sep 2025	7,279	102,474 (0%)	0%	445.6	3,243,741	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 400.03 per share.	21 Aug 2025	6,485	110,884 (0%)	0%	400.0	2,594,225	Common Stock
Mr. William John Sibold	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 401.00 per share.	21 Aug 2025	1,131	109,753 (0%)	0%	401	453,531	Common Stock
Ms. Shannon T. Kelley	General Counsel	Sale of securities on an exchange or to another person at price $ 358.66 per share.	18 Aug 2025	458	10,019 (0%)	0%	358.7	164,266	Common Stock
Ms. Shannon T. Kelley	General Counsel	Sale of securities on an exchange or to another person at price $ 376.62 per share.	18 Aug 2025	42	9,173 (0%)	0%	376.6	15,818	Common Stock
Ms. Shannon T. Kelley	General Counsel	Sale of securities on an exchange or to another person at price $ 375.75 per share.	18 Aug 2025	190	9,215 (0%)	0%	375.8	71,393	Common Stock
Ms. Shannon T. Kelley	General Counsel	Sale of securities on an exchange or to another person at price $ 374.13 per share.	18 Aug 2025	68	9,405 (0%)	0%	374.1	25,441	Common Stock
Ms. Shannon T. Kelley	General Counsel	Sale of securities on an exchange or to another person at price $ 372.44 per share.	18 Aug 2025	252	9,473 (0%)	0%	372.4	93,855	Common Stock
Ms. Shannon T. Kelley	General Counsel	Sale of securities on an exchange or to another person at price $ 371.35 per share.	18 Aug 2025	84	9,725 (0%)	0%	371.3	31,193	Common Stock
Ms. Shannon T. Kelley	General Counsel	Sale of securities on an exchange or to another person at price $ 370.06 per share.	18 Aug 2025	84	9,809 (0%)	0%	370.1	31,085	Common Stock
Ms. Shannon T. Kelley	General Counsel	Sale of securities on an exchange or to another person at price $ 369.64 per share.	18 Aug 2025	126	9,893 (0%)	0%	369.6	46,575	Common Stock
Mr. Kenneth M. Bate	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.46 per share.	15 Aug 2025	10,000	12,627 (0%)	0%	16.5	164,600	Common Stock
Mr. Kenneth M. Bate	Director		15 Aug 2025	10,000	0	-		-	Stock Option (Right to Buy)
Mr. Kenneth M. Bate	Director	Sale of securities on an exchange or to another person at price $ 368.56 per share.	15 Aug 2025	896	2,627 (0%)	0%	368.6	330,226	Common Stock
Mr. Kenneth M. Bate	Director	Sale of securities on an exchange or to another person at price $ 367.63 per share.	15 Aug 2025	1,104	3,523 (0%)	0%	367.6	405,865	Common Stock
Mr. Kenneth M. Bate	Director	Sale of securities on an exchange or to another person at price $ 366.14 per share.	15 Aug 2025	600	4,627 (0%)	0%	366.1	219,683	Common Stock
Mr. Kenneth M. Bate	Director	Sale of securities on an exchange or to another person at price $ 365.33 per share.	15 Aug 2025	2,567	5,227 (0%)	0%	365.3	937,793	Common Stock
Mr. Kenneth M. Bate	Director	Sale of securities on an exchange or to another person at price $ 364.24 per share.	15 Aug 2025	2,516	7,794 (0%)	0%	364.2	916,428	Common Stock
Mr. Kenneth M. Bate	Director	Sale of securities on an exchange or to another person at price $ 363.41 per share.	15 Aug 2025	2,317	10,310 (0%)	0%	363.4	842,014	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.45 per share.	13 Aug 2025	129,172	316,336 (2%)	0%	9.4	1,220,675	Common Stock
Dr. Paul A. Friedman,M.D.	Director		13 Aug 2025	129,172	0	-		-	Stock Option (Right to Buy)
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 374.38 per share.	13 Aug 2025	4,155	187,164 (1%)	0%	374.4	1,555,563	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 373.35 per share.	13 Aug 2025	24,166	191,319 (1%)	0%	373.3	9,022,330	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 372.39 per share.	13 Aug 2025	28,976	215,485 (1%)	0%	372.4	10,790,486	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 371.53 per share.	13 Aug 2025	22,710	244,461 (1%)	0%	371.5	8,437,340	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 370.44 per share.	13 Aug 2025	7,877	267,171 (1%)	0%	370.4	2,917,943	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 369.44 per share.	13 Aug 2025	7,992	275,048 (1%)	0%	369.4	2,952,555	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 368.34 per share.	13 Aug 2025	6,788	283,040 (1%)	0%	368.3	2,500,325	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 367.31 per share.	13 Aug 2025	7,119	289,828 (1%)	0%	367.3	2,614,888	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 366.22 per share.	13 Aug 2025	3,152	296,947 (1%)	0%	366.2	1,154,330	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 365.19 per share.	13 Aug 2025	1,716	300,099 (1%)	0%	365.2	626,671	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 364.02 per share.	13 Aug 2025	3,529	301,815 (1%)	0%	364.0	1,284,639	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 363.08 per share.	13 Aug 2025	2,591	305,344 (1%)	0%	363.1	940,731	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 362.29 per share.	13 Aug 2025	1,439	307,935 (1%)	0%	362.3	521,332	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 361.13 per share.	13 Aug 2025	1,754	309,374 (2%)	0%	361.1	633,424	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 360.27 per share.	13 Aug 2025	3,153	311,128 (2%)	0%	360.3	1,135,938	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 359.31 per share.	13 Aug 2025	455	314,281 (2%)	0%	359.3	163,485	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 358.23 per share.	13 Aug 2025	1,600	314,736 (2%)	0%	358.2	573,171	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 350.19 per share.	11 Aug 2025	2,903	187,464 (1%)	0%	350.2	1,016,605	Common Stock
Dr. Paul A. Friedman,M.D.	Director		11 Aug 2025	43,605	129,172	-		-	Stock Option (Right to Buy)
Dr. Paul A. Friedman,M.D.	Director		11 Aug 2025	3,203	172,777	-		-	Stock Option (Right to Buy)
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 359.81 per share.	11 Aug 2025	600	187,164 (1%)	0%	359.8	215,886	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 358.83 per share.	11 Aug 2025	5,032	187,764 (1%)	0%	358.8	1,805,615	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 357.93 per share.	11 Aug 2025	8,434	192,796 (1%)	0%	357.9	3,018,786	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 356.94 per share.	11 Aug 2025	5,094	201,230 (1%)	0%	356.9	1,818,251	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 355.97 per share.	11 Aug 2025	5,244	206,324 (1%)	0%	356.0	1,866,710	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 355.00 per share.	11 Aug 2025	6,546	211,568 (1%)	0%	355.0	2,323,856	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 354.06 per share.	11 Aug 2025	4,768	218,114 (1%)	0%	354.1	1,688,137	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 352.61 per share.	11 Aug 2025	1,382	222,882 (1%)	0%	352.6	487,309	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 351.59 per share.	11 Aug 2025	3,202	224,264 (1%)	0%	351.6	1,125,806	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 350.93 per share.	11 Aug 2025	3,303	227,466 (1%)	0%	350.9	1,159,113	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.45 per share.	11 Aug 2025	43,605	230,769 (1%)	0%	9.4	412,067	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 351.04 per share.	11 Aug 2025	300	187,164 (1%)	0%	351.0	105,312	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.45 per share.	11 Aug 2025	3,203	190,367 (1%)	0%	9.4	30,268	Common Stock
Dr. Rebecca A. Taub,M.D.	Director		11 Aug 2025	43,263	0	-		-	Stock Option (Right to Buy)
Dr. Rebecca A. Taub,M.D.	Director		11 Aug 2025	3,200	43,263	-		-	Stock Option (Right to Buy)
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 359.71 per share.	11 Aug 2025	700	461,044 (2%)	0%	359.7	251,798	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 358.81 per share.	11 Aug 2025	6,541	461,744 (2%)	0%	358.8	2,346,983	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 357.85 per share.	11 Aug 2025	6,715	468,285 (3%)	0%	357.9	2,402,982	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 356.88 per share.	11 Aug 2025	4,864	475,000 (3%)	0%	356.9	1,735,861	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 355.95 per share.	11 Aug 2025	5,752	479,864 (3%)	0%	356.0	2,047,436	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 354.97 per share.	11 Aug 2025	6,479	485,616 (3%)	0%	355.0	2,299,873	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 354.04 per share.	11 Aug 2025	4,587	492,095 (3%)	0%	354.0	1,623,997	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 352.45 per share.	11 Aug 2025	1,175	496,682 (3%)	0%	352.5	414,130	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 351.60 per share.	11 Aug 2025	2,870	497,857 (3%)	0%	351.6	1,009,091	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 350.87 per share.	11 Aug 2025	3,580	500,727 (3%)	0%	350.9	1,256,127	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.45 per share.	11 Aug 2025	43,263	504,307 (3%)	0%	9.4	408,835	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 351.02 per share.	11 Aug 2025	220	461,044 (2%)	0%	351.0	77,225	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 350.18 per share.	11 Aug 2025	2,980	461,264 (2%)	0%	350.2	1,043,528	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.45 per share.	11 Aug 2025	3,200	464,244 (3%)	0%	9.5	30,240	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 350.03 per share.	18 Jul 2025	1,400	187,164 (1%)	0%	350.0	490,044	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.45 per share.	18 Jul 2025	1,400	188,564 (1%)	0%	9.5	13,230	Common Stock
Dr. Paul A. Friedman,M.D.	Director		18 Jul 2025	1,400	175,980	-		-	Stock Option (Right to Buy)
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 350.00 per share.	18 Jul 2025	1,000	461,044 (2%)	0%	350.0	350,005	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.45 per share.	18 Jul 2025	1,000	462,044 (2%)	0%	9.5	9,450	Common Stock
Dr. Rebecca A. Taub,M.D.	Director		18 Jul 2025	1,000	46,463	-		-	Stock Option (Right to Buy)
Dr. Paul A. Friedman,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.45 per share.	16 Jul 2025	26,176	213,340 (1%)	0%	9.4	247,363	Common Stock
Dr. Paul A. Friedman,M.D.	Director		16 Jul 2025	26,176	180,080	-		-	Stock Option (Right to Buy)
Dr. Paul A. Friedman,M.D.	Director		16 Jul 2025	2,700	177,380	-		-	Stock Option (Right to Buy)
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 351.57 per share.	16 Jul 2025	700	187,164 (1%)	0%	351.6	246,098	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 350.10 per share.	16 Jul 2025	2,000	187,864 (1%)	0%	350.1	700,203	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.45 per share.	16 Jul 2025	2,700	189,864 (1%)	0%	9.5	25,515	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 356.62 per share.	16 Jul 2025	1,200	187,164 (1%)	0%	356.6	427,941	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 355.61 per share.	16 Jul 2025	5,784	188,364 (1%)	0%	355.6	2,056,860	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 354.65 per share.	16 Jul 2025	6,851	194,148 (1%)	0%	354.6	2,429,697	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 353.82 per share.	16 Jul 2025	2,319	200,999 (1%)	0%	353.8	820,507	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 352.67 per share.	16 Jul 2025	2,110	203,318 (1%)	0%	352.7	744,133	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 351.38 per share.	16 Jul 2025	2,371	205,428 (1%)	0%	351.4	833,131	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Sale of securities on an exchange or to another person at price $ 350.17 per share.	16 Jul 2025	5,541	207,799 (1%)	0%	350.2	1,940,275	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 350.19 per share.	16 Jul 2025	6,000	481,488 (3%)	0%	350.2	2,101,142	Common Stock
Dr. Rebecca A. Taub,M.D.	Director		16 Jul 2025	2,657	47,463	-		-	Stock Option (Right to Buy)
Dr. Rebecca A. Taub,M.D.	Director		16 Jul 2025	26,444	50,120	-		-	Stock Option (Right to Buy)
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 351.50 per share.	16 Jul 2025	600	461,044 (2%)	0%	351.5	210,898	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 350.09 per share.	16 Jul 2025	2,057	461,644 (2%)	0%	350.1	720,137	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.45 per share.	16 Jul 2025	2,657	463,701 (3%)	0%	9.5	25,109	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 356.52 per share.	16 Jul 2025	1,380	461,044 (2%)	0%	356.5	492,004	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 355.61 per share.	16 Jul 2025	6,441	462,424 (2%)	0%	355.6	2,290,499	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 354.61 per share.	16 Jul 2025	5,800	468,865 (3%)	0%	354.6	2,056,738	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 353.82 per share.	16 Jul 2025	2,569	474,665 (3%)	0%	353.8	908,963	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 352.64 per share.	16 Jul 2025	2,357	477,234 (3%)	0%	352.6	831,170	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Sale of securities on an exchange or to another person at price $ 351.37 per share.	16 Jul 2025	1,897	479,591 (3%)	0%	351.4	666,546	Common Stock
Dr. Rebecca A. Taub,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.45 per share.	16 Jul 2025	26,444	487,488 (3%)	0%	9.5	249,896	Common Stock
Dr. Paul A. Friedman,M.D.	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	20 Jun 2025	715	187,164 (1%)	0%		0	Common Stock
Dr. Paul A. Friedman,M.D.	Director		20 Jun 2025	1,290	1,290	-		-	Stock Option (Right to Buy)
Dr. Jacqualyn A. Fouse, PhD	Director		20 Jun 2025	366	366	-		-	Stock Option (Right to Buy)
Dr. Jacqualyn A. Fouse, PhD	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	20 Jun 2025	203	1,097 (0%)	0%		0	Common Stock
Mr. Kenneth M. Bate	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	20 Jun 2025	715	2,627 (0%)	0%		0	Common Stock
Mr. Kenneth M. Bate	Director		20 Jun 2025	1,290	1,290	-		-	Stock Option (Right to Buy)
Dr. Richard S. Levy,M.D.	Director		20 Jun 2025	1,290	1,290	-		-	Stock Option (Right to Buy)
Dr. Richard S. Levy,M.D.	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	20 Jun 2025	715	21,197 (0%)	0%		0	Common Stock
Mr. James M. Daly	Director		20 Jun 2025	1,290	1,290	-		-	Stock Option (Right to Buy)
Mr. James M. Daly	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	20 Jun 2025	715	2,627 (0%)	0%		0	Common Stock
Dr. David Soergel, PhD.	Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 May 2025	7,545	7,545 (0%)	0%		0	Common Stock
Dr. David Soergel, PhD.	Chief Medical Officer		15 May 2025	12,839	12,839	-		-	Stock Option (Right to Buy)
Dr. Richard S. Levy,M.D.	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 65.06 per share.	10 Apr 2025	9,470	20,482 (0%)	0%	65.1	616,118	Common Stock
Dr. Richard S. Levy,M.D.	Director		10 Apr 2025	9,470	0	-		-	Stock Option (Right to Buy)
Dr. Frederick B. Craves, PhD	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 65.06 per share.	12 Mar 2025	1,728	351,804 (2%)	0%	65.1	112,424	Common Stock
Dr. Frederick B. Craves, PhD	Director		12 Mar 2025	7,742	0	-		-	Stock Option (Right to Buy)
Dr. Frederick B. Craves, PhD	Director		12 Mar 2025	6,000	0	-		-	Stock Option (Right to Buy)
Dr. Frederick B. Craves, PhD	Director		12 Mar 2025	1,728	7,742	-		-	Stock Option (Right to Buy)
Dr. Frederick B. Craves, PhD	Director	Sale of securities on an exchange or to another person at price $ 330.23 per share.	12 Mar 2025	75	350,076 (2%)	0%	330.2	24,767	Common Stock
Dr. Frederick B. Craves, PhD	Director	Sale of securities on an exchange or to another person at price $ 329.86 per share.	12 Mar 2025	967	350,151 (2%)	0%	329.9	318,975	Common Stock
Dr. Frederick B. Craves, PhD	Director	Sale of securities on an exchange or to another person at price $ 328.68 per share.	12 Mar 2025	400	351,118 (2%)	0%	328.7	131,472	Common Stock
Dr. Frederick B. Craves, PhD	Director	Sale of securities on an exchange or to another person at price $ 327.63 per share.	12 Mar 2025	1,000	351,518 (2%)	0%	327.6	327,627	Common Stock
Dr. Frederick B. Craves, PhD	Director	Sale of securities on an exchange or to another person at price $ 325.63 per share.	12 Mar 2025	800	352,518 (2%)	0%	325.6	260,501	Common Stock
Dr. Frederick B. Craves, PhD	Director	Sale of securities on an exchange or to another person at price $ 324.69 per share.	12 Mar 2025	900	353,318 (2%)	0%	324.7	292,218	Common Stock
Dr. Frederick B. Craves, PhD	Director	Sale of securities on an exchange or to another person at price $ 323.47 per share.	12 Mar 2025	1,649	354,218 (2%)	0%	323.5	533,394	Common Stock
Dr. Frederick B. Craves, PhD	Director	Sale of securities on an exchange or to another person at price $ 322.45 per share.	12 Mar 2025	1,951	355,867 (2%)	0%	322.5	629,100	Common Stock
Dr. Frederick B. Craves, PhD	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 65.06 per share.	12 Mar 2025	7,742	357,818 (2%)	0%	65.1	503,695	Common Stock
Dr. Frederick B. Craves, PhD	Director	Sale of securities on an exchange or to another person at price $ 334.97 per share.	12 Mar 2025	200	350,076 (2%)	0%	335.0	66,994	Common Stock
Dr. Frederick B. Craves, PhD	Director	Sale of securities on an exchange or to another person at price $ 333.66 per share.	12 Mar 2025	800	350,276 (2%)	0%	333.7	266,926	Common Stock
Dr. Frederick B. Craves, PhD	Director	Sale of securities on an exchange or to another person at price $ 332.38 per share.	12 Mar 2025	2,382	351,076 (2%)	0%	332.4	791,726	Common Stock
Dr. Frederick B. Craves, PhD	Director	Sale of securities on an exchange or to another person at price $ 331.36 per share.	12 Mar 2025	2,759	353,458 (2%)	0%	331.4	914,221	Common Stock
Dr. Frederick B. Craves, PhD	Director	Sale of securities on an exchange or to another person at price $ 330.54 per share.	12 Mar 2025	1,587	356,217 (2%)	0%	330.5	524,560	Common Stock
Dr. Frederick B. Craves, PhD	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 111.06 per share.	12 Mar 2025	6,000	357,804 (2%)	0%	111.1	666,360	Common Stock
Dr. Jacqualyn A. Fouse, PhD	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	10 Mar 2025	894	894 (0%)	0%		0	Common Stock
Dr. Jacqualyn A. Fouse, PhD	Director		10 Mar 2025	1,579	1,579	-		-	Stock Option (Right to Buy)
Ms. Mardi C. Dier	SVP and CFO	Sale of securities on an exchange or to another person at price $ 323.04 per share.	10 Mar 2025	258	10,440 (0%)	0%	323.0	83,344	Common Stock
Dr. Rebecca A. Taub,M.D.	Director, Pres., R&D, and CMO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	05 Mar 2025	4,382	461,044 (2%)	0%		0	Common Stock
Dr. Rebecca A. Taub,M.D.	Director, Pres., R&D, and CMO		05 Mar 2025	7,381	7,381	-		-	Stock Option (Right to Buy)
Mr. William John Sibold	Director, President and CEO		05 Mar 2025	22,009	22,009	-		-	Stock Option (Right to Buy)
Mr. William John Sibold	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	05 Mar 2025	13,066	117,369 (0%)	0%		0	Common Stock
Ms. Mardi C. Dier	SVP and CFO		05 Mar 2025	6,374	6,374	-		-	Stock Option (Right to Buy)
Ms. Mardi C. Dier	SVP and CFO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	05 Mar 2025	3,784	10,698 (0%)	0%		0	Common Stock
Dr. Robert E. Waltermire, PhD	Senior VP, Chief Pharma Dev.	Sale of securities on an exchange or to another person at price $ 344.76 per share.	05 Mar 2025	1,412	3,728 (0%)	0%	344.8	486,797	Common Stock
Dr. Robert E. Waltermire, PhD	Senior VP, Chief Pharma Dev.	Sale of securities on an exchange or to another person at price $ 343.85 per share.	05 Mar 2025	4,701	5,140 (0%)	0%	343.8	1,616,429	Common Stock
Dr. Robert E. Waltermire, PhD	Senior VP, Chief Pharma Dev.	Sale of securities on an exchange or to another person at price $ 342.90 per share.	05 Mar 2025	1,077	9,841 (0%)	0%	342.9	369,300	Common Stock
Dr. Robert E. Waltermire, PhD	Senior VP, Chief Pharma Dev.	Sale of securities on an exchange or to another person at price $ 341.84 per share.	05 Mar 2025	1,043	10,918 (0%)	0%	341.8	356,537	Common Stock
Dr. Robert E. Waltermire, PhD	Senior VP, Chief Pharma Dev.	Sale of securities on an exchange or to another person at price $ 340.75 per share.	05 Mar 2025	1,657	11,961 (0%)	0%	340.8	564,627	Common Stock
Dr. Robert E. Waltermire, PhD	Senior VP, Chief Pharma Dev.		05 Mar 2025	1,157	1,157	-		-	Stock Option (Right to Buy)
Dr. Robert E. Waltermire, PhD	Senior VP, Chief Pharma Dev.	Sale of securities on an exchange or to another person at price $ 338.09 per share.	05 Mar 2025	1,146	14,018 (0%)	0%	338.1	387,452	Common Stock
Dr. Robert E. Waltermire, PhD	Senior VP, Chief Pharma Dev.	Sale of securities on an exchange or to another person at price $ 336.78 per share.	05 Mar 2025	1,777	15,164 (0%)	0%	336.8	598,457	Common Stock
Dr. Robert E. Waltermire, PhD	Senior VP, Chief Pharma Dev.	Sale of securities on an exchange or to another person at price $ 335.15 per share.	05 Mar 2025	900	16,941 (0%)	0%	335.1	301,631	Common Stock
Dr. Robert E. Waltermire, PhD	Senior VP, Chief Pharma Dev.	Exercise or conversion of derivative security received from the company (such as an option) at price $ 87.09 per share.	05 Mar 2025	7,288	17,841 (0%)	0%	87.1	634,712	Common Stock
Dr. Robert E. Waltermire, PhD	Senior VP, Chief Pharma Dev.	Exercise or conversion of derivative security received from the company (such as an option) at price $ 87.92 per share.	05 Mar 2025	6,825	10,553 (0%)	0%	87.9	600,054	Common Stock
Dr. Robert E. Waltermire, PhD	Senior VP, Chief Pharma Dev.	Sale of securities on an exchange or to another person at price $ 339.68 per share.	05 Mar 2025	400	13,618 (0%)	0%	339.7	135,874	Common Stock
Dr. Robert E. Waltermire, PhD	Senior VP, Chief Pharma Dev.		05 Mar 2025	7,288	3,062	-		-	Stock Option (Right to Buy)
Dr. Robert E. Waltermire, PhD	Senior VP, Chief Pharma Dev.		05 Mar 2025	6,825	4,375	-		-	Stock Option (Right to Buy)
Dr. Robert E. Waltermire, PhD	Senior VP, Chief Pharma Dev.	Grant, award, or other acquisition of securities at price $ 0.00 per share.	05 Mar 2025	2,061	5,789 (0%)	0%		0	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer		05 Mar 2025	5,703	5,703	-		-	Stock Option (Right to Buy)
Ms. Carole Huntsman	Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	05 Mar 2025	3,386	11,990 (0%)	0%		0	Common Stock
Ms. Shannon T. Kelley	General Counsel	Grant, award, or other acquisition of securities at price $ 0.00 per share.	05 Mar 2025	3,187	10,477 (0%)	0%		0	Common Stock
Ms. Shannon T. Kelley	General Counsel		05 Mar 2025	5,368	5,368	-		-	Stock Option (Right to Buy)
Ms. Mardi C. Dier	SVP and CFO	Sale of securities on an exchange or to another person at price $ 323.54 per share.	03 Mar 2025	774	6,914 (0%)	0%	323.5	250,417	Common Stock
Ms. Mardi C. Dier	SVP and CFO	Sale of securities on an exchange or to another person at price $ 325.89 per share.	03 Mar 2025	1,187	7,688 (0%)	0%	325.9	386,831	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 314.74 per share.	03 Mar 2025	200	10,167 (0%)	0%	314.7	62,948	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 313.08 per share.	03 Mar 2025	71	10,367 (0%)	0%	313.1	22,229	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 335.00 per share.	03 Mar 2025	563	8,604 (0%)	0%	335	188,605	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 329.64 per share.	03 Mar 2025	100	9,167 (0%)	0%	329.6	32,964	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 327.49 per share.	03 Mar 2025	100	9,267 (0%)	0%	327.5	32,749	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 326.34 per share.	03 Mar 2025	100	9,367 (0%)	0%	326.3	32,634	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 324.59 per share.	03 Mar 2025	200	9,467 (0%)	0%	324.6	64,918	Common Stock
Ms. Carole Huntsman	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 323.65 per share.	03 Mar 2025	200	9,667 (0%)	0%	323.7	64,730	Common Stock

*All Values are in $ Million

Client Category: Promoter/ KMP/ Director / Immediate Relatives / Employee / etc
Security Type: Share/ Warrants / Convertible Debentures

Data as reported to USA Exchanges

View All The Insider Trades disclosures

Insider Trading disclosures for Madrigal Pharma Inc

The latest disclosure was made by Mr. William John Sibold in Madrigal Pharma Inc where a trade of 131 Common Stock done at an average price of $527.9 was reported to US exchanges on Sept. 9, 2026.

Screeners based on Insider Trading and SAST parameters