XNAS 06 Nov, 2025 4:30 PM (EST)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.89 per share. | 30 Oct 2025 | 21,800 | 70,886 | - | 6.9 | 150,202 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2025 | 21,800 | 118,808 | - | - | Stock Option (Right to Buy) | |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 104.78 per share. | 30 Oct 2025 | 9,382 | 49,086 | - | 104.8 | 983,046 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 103.90 per share. | 30 Oct 2025 | 3,491 | 58,468 | - | 103.9 | 362,715 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 102.88 per share. | 30 Oct 2025 | 3,733 | 61,959 | - | 102.9 | 384,051 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 102.00 per share. | 30 Oct 2025 | 2,121 | 65,692 | - | 102 | 216,342 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 100.96 per share. | 30 Oct 2025 | 600 | 67,813 | - | 101.0 | 60,576 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 99.66 per share. | 30 Oct 2025 | 500 | 68,413 | - | 99.7 | 49,830 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 97.98 per share. | 30 Oct 2025 | 1,273 | 68,913 | - | 98.0 | 124,729 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 96.65 per share. | 30 Oct 2025 | 700 | 70,186 | - | 96.7 | 67,655 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 98.91 per share. | 30 Oct 2025 | 57 | 51,977 | - | 98.9 | 5,638 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2025 | 4,000 | 122,329 | - | - | Stock Option (Right to Buy) | |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 104.58 per share. | 30 Oct 2025 | 218 | 48,034 | - | 104.6 | 22,798 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 104.21 per share. | 30 Oct 2025 | 1,114 | 48,252 | - | 104.2 | 116,090 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 103.09 per share. | 30 Oct 2025 | 1,091 | 49,366 | - | 103.1 | 112,471 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 102.07 per share. | 30 Oct 2025 | 1,170 | 50,457 | - | 102.1 | 119,422 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 100.69 per share. | 30 Oct 2025 | 350 | 51,627 | - | 100.7 | 35,242 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 30 Oct 2025 | 4,000 | 52,034 | - | 27.9 | 111,400 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 100.23 per share. | 27 Oct 2025 | 4,046 | 212,476 | - | 100.2 | 405,531 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 100.27 per share. | 27 Oct 2025 | 9,154 | 203,322 | - | 100.3 | 917,872 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 100.27 per share. | 27 Oct 2025 | 32,455 | 1,383,044 | - | 100.3 | 3,254,263 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 100.23 per share. | 27 Oct 2025 | 14,345 | 1,415,499 | - | 100.2 | 1,437,799 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.89 per share. | 20 Oct 2025 | 5,000 | 54,086 | - | 6.9 | 34,450 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Oct 2025 | 5,000 | 140,608 | - | - | Stock Option (Right to Buy) | |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 94.91 per share. | 20 Oct 2025 | 5,000 | 49,086 | - | 94.9 | 474,550 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 16 Oct 2025 | 27,000 | 276,062 | - | 18.9 | 511,110 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Oct 2025 | 27,000 | 222,400 | - | - | Stock Option (Right to Buy) | |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 92.63 per share. | 16 Oct 2025 | 700 | 249,062 | - | 92.6 | 64,841 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 92.19 per share. | 16 Oct 2025 | 1,114 | 249,762 | - | 92.2 | 102,700 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 90.91 per share. | 16 Oct 2025 | 13,876 | 250,876 | - | 90.9 | 1,261,467 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 90.01 per share. | 16 Oct 2025 | 11,310 | 264,752 | - | 90.0 | 1,018,013 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 85.57 per share. | 15 Oct 2025 | 1,683 | 61,734 | - | 85.6 | 144,014 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2025 | 1,683 | 28,979 | - | - | Stock Option (Right to Buy) | |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 15 Oct 2025 | 1,683 | 63,417 | - | 18.9 | 31,859 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 89.98 per share. | 15 Oct 2025 | 15,624 | 49,086 | - | 90.0 | 1,405,848 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2025 | 12,376 | 145,608 | - | - | Stock Option (Right to Buy) | |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2025 | 15,624 | 157,984 | - | - | Stock Option (Right to Buy) | |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 92.50 per share. | 15 Oct 2025 | 4,900 | 49,086 | - | 92.5 | 453,250 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 91.37 per share. | 15 Oct 2025 | 5,199 | 53,986 | - | 91.4 | 475,033 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 90.54 per share. | 15 Oct 2025 | 2,277 | 59,185 | - | 90.5 | 206,160 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.89 per share. | 15 Oct 2025 | 12,376 | 61,462 | - | 6.9 | 85,271 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.89 per share. | 15 Oct 2025 | 15,624 | 64,710 | - | 6.9 | 107,649 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 15 Oct 2025 | 7,495 | 77,126 | - | 27.9 | 208,736 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2025 | 3,042 | 24,058 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2025 | 7,495 | 13,156 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2025 | 3,668 | 10,569 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 90.04 per share. | 15 Oct 2025 | 14,205 | 65,963 | - | 90.0 | 1,279,018 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 72.35 per share. | 15 Oct 2025 | 3,042 | 80,168 | - | 72.4 | 220,089 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 15 Oct 2025 | 3,668 | 69,631 | - | 18.9 | 69,435 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.89 per share. | 13 Oct 2025 | 6,875 | 68,609 | - | 6.9 | 47,369 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Oct 2025 | 20,000 | 30,662 | - | - | Stock Option (Right to Buy) | |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Oct 2025 | 13,125 | 50,662 | - | - | Stock Option (Right to Buy) | |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Oct 2025 | 6,875 | 35,976 | - | - | Stock Option (Right to Buy) | |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 88.90 per share. | 13 Oct 2025 | 200 | 61,734 | - | 88.9 | 17,780 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 87.67 per share. | 13 Oct 2025 | 1,700 | 61,934 | - | 87.7 | 149,039 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 86.63 per share. | 13 Oct 2025 | 5,820 | 63,634 | - | 86.6 | 504,187 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 85.75 per share. | 13 Oct 2025 | 12,280 | 69,454 | - | 85.8 | 1,053,010 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 13 Oct 2025 | 20,000 | 81,734 | - | 18.9 | 378,600 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 89.22 per share. | 13 Oct 2025 | 1,596 | 61,734 | - | 89.2 | 142,395 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 88.73 per share. | 13 Oct 2025 | 12,266 | 63,330 | - | 88.7 | 1,088,362 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 87.90 per share. | 13 Oct 2025 | 6,138 | 75,596 | - | 87.9 | 539,530 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 13 Oct 2025 | 13,125 | 81,734 | - | 18.9 | 248,456 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 87.39 per share. | 13 Oct 2025 | 400 | 65,963 | - | 87.4 | 34,956 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Oct 2025 | 825 | 14,025 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Oct 2025 | 877 | 20,651 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Oct 2025 | 731 | 14,237 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Oct 2025 | 1,800 | 27,100 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Oct 2025 | 4,168 | 21,528 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Oct 2025 | 1,669 | 14,968 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 86.11 per share. | 13 Oct 2025 | 866 | 66,363 | - | 86.1 | 74,571 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 84.98 per share. | 13 Oct 2025 | 1,167 | 67,229 | - | 85.0 | 99,172 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.33 per share. | 13 Oct 2025 | 825 | 68,396 | - | 29.3 | 24,197 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 13 Oct 2025 | 877 | 67,571 | - | 27.8 | 24,424 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 13 Oct 2025 | 731 | 66,694 | - | 18.9 | 13,838 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 89.81 per share. | 13 Oct 2025 | 7,637 | 65,963 | - | 89.8 | 685,879 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 72.35 per share. | 13 Oct 2025 | 1,800 | 73,600 | - | 72.4 | 130,230 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 13 Oct 2025 | 4,168 | 71,800 | - | 27.9 | 116,079 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 13 Oct 2025 | 1,669 | 67,632 | - | 18.9 | 31,594 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.89 per share. | 01 Oct 2025 | 16,787 | 78,521 | - | 6.9 | 115,662 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2025 | 3,213 | 63,787 | - | - | Stock Option (Right to Buy) | |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2025 | 16,787 | 42,851 | - | - | Stock Option (Right to Buy) | |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 86.37 per share. | 01 Oct 2025 | 970 | 61,734 | - | 86.4 | 83,779 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 85.43 per share. | 01 Oct 2025 | 19,030 | 62,704 | - | 85.4 | 1,625,733 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 01 Oct 2025 | 3,213 | 81,734 | - | 18.9 | 60,822 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Sep 2025 | 20,000 | 59,638 | - | - | Stock Option (Right to Buy) | |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Sep 2025 | 7,588 | 79,638 | - | - | Stock Option (Right to Buy) | |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 85.06 per share. | 29 Sep 2025 | 20,000 | 61,734 | - | 85.1 | 1,701,200 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.89 per share. | 29 Sep 2025 | 20,000 | 81,734 | - | 6.9 | 137,800 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 85.01 per share. | 29 Sep 2025 | 7,588 | 61,734 | - | 85.0 | 645,056 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.89 per share. | 29 Sep 2025 | 7,588 | 69,322 | - | 6.9 | 52,281 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 29 Sep 2025 | 4,000 | 52,034 | - | 27.9 | 111,400 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 81.39 per share. | 29 Sep 2025 | 1,224 | 50,810 | - | 81.4 | 99,621 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Sep 2025 | 4,000 | 126,329 | - | - | Stock Option (Right to Buy) | |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 84.92 per share. | 29 Sep 2025 | 417 | 48,034 | - | 84.9 | 35,412 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 84.53 per share. | 29 Sep 2025 | 1,083 | 48,451 | - | 84.5 | 91,546 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 83.20 per share. | 29 Sep 2025 | 754 | 49,534 | - | 83.2 | 62,733 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 82.33 per share. | 29 Sep 2025 | 522 | 50,288 | - | 82.3 | 42,976 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 80.12 per share. | 15 Sep 2025 | 2,097 | 249,062 | - | 80.1 | 168,012 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 79.30 per share. | 15 Sep 2025 | 16,080 | 251,159 | - | 79.3 | 1,275,144 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 78.42 per share. | 15 Sep 2025 | 8,823 | 267,239 | - | 78.4 | 691,900 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 15 Sep 2025 | 27,000 | 276,062 | - | 18.9 | 511,110 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Sep 2025 | 27,000 | 249,400 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 10 Sep 2025 | 731 | 66,694 | - | 18.9 | 13,838 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2025 | 731 | 16,637 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2025 | 877 | 25,696 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2025 | 2,117 | 14,850 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 78.83 per share. | 10 Sep 2025 | 3,725 | 65,963 | - | 78.8 | 293,642 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.33 per share. | 10 Sep 2025 | 2,117 | 69,688 | - | 29.3 | 62,092 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 10 Sep 2025 | 877 | 67,571 | - | 27.8 | 24,424 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Aug 2025 | 3,000 | 5,085 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Aug 2025 | 2,007 | 0 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.08 per share. | 29 Aug 2025 | 3,000 | 65,963 | - | 1.1 | 3,240 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.87 per share. | 29 Aug 2025 | 2,007 | 62,963 | - | 0.9 | 1,746 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 73.96 per share. | 25 Aug 2025 | 1,348 | 50,686 | - | 74.0 | 99,698 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 74.93 per share. | 25 Aug 2025 | 2,543 | 48,143 | - | 74.9 | 190,547 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 25 Aug 2025 | 4,000 | 52,034 | - | 27.9 | 111,400 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.63 per share. | 25 Aug 2025 | 109 | 48,034 | - | 75.6 | 8,244 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Aug 2025 | 4,000 | 130,329 | - | - | Stock Option (Right to Buy) | |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 76.90 per share. | 15 Aug 2025 | 100 | 249,062 | - | 76.9 | 7,690 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 75.98 per share. | 15 Aug 2025 | 6,865 | 249,162 | - | 76.0 | 521,603 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 75.22 per share. | 15 Aug 2025 | 20,035 | 256,027 | - | 75.2 | 1,507,033 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 15 Aug 2025 | 27,000 | 276,062 | - | 18.9 | 511,110 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Aug 2025 | 27,000 | 276,400 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 07 Aug 2025 | 731 | 61,687 | - | 18.9 | 13,838 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 74.85 per share. | 07 Aug 2025 | 5,500 | 60,956 | - | 74.9 | 411,675 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Aug 2025 | 731 | 17,368 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Aug 2025 | 877 | 26,573 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Aug 2025 | 3,892 | 16,967 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.33 per share. | 07 Aug 2025 | 3,892 | 66,456 | - | 29.3 | 114,152 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 07 Aug 2025 | 877 | 62,564 | - | 27.8 | 24,424 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 30 Jul 2025 | 4,000 | 52,034 | - | 27.9 | 111,400 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2025 | 4,000 | 134,329 | - | - | Stock Option (Right to Buy) | |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 80.36 per share. | 30 Jul 2025 | 4,000 | 48,034 | - | 80.4 | 321,440 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 83.94 per share. | 15 Jul 2025 | 1,496 | 249,166 | - | 83.9 | 125,574 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 82.31 per share. | 15 Jul 2025 | 19,997 | 250,662 | - | 82.3 | 1,645,953 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 81.64 per share. | 15 Jul 2025 | 5,403 | 270,659 | - | 81.6 | 441,101 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 15 Jul 2025 | 27,000 | 276,062 | - | 18.9 | 511,110 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 84.53 per share. | 15 Jul 2025 | 104 | 249,062 | - | 84.5 | 8,791 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 27,000 | 303,400 | - | - | Stock Option (Right to Buy) | |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 84.91 per share. | 15 Jul 2025 | 874 | 61,788 | - | 84.9 | 74,211 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 83.87 per share. | 15 Jul 2025 | 1,888 | 62,662 | - | 83.9 | 158,347 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 15 Jul 2025 | 5,300 | 67,034 | - | 18.9 | 100,329 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 82.67 per share. | 15 Jul 2025 | 2,484 | 64,550 | - | 82.7 | 205,352 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 14,700 | 67,000 | - | - | Stock Option (Right to Buy) | |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 5,300 | 81,700 | - | - | Stock Option (Right to Buy) | |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 85.10 per share. | 15 Jul 2025 | 14,700 | 61,734 | - | 85.1 | 1,250,970 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 15 Jul 2025 | 14,700 | 76,434 | - | 18.9 | 278,271 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 85.48 per share. | 15 Jul 2025 | 54 | 61,734 | - | 85.5 | 4,616 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 81.08 per share. | 09 Jul 2025 | 1,945 | 61,156 | - | 81.1 | 157,701 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jul 2025 | 4,440 | 20,859 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jul 2025 | 878 | 27,450 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jul 2025 | 182 | 18,099 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 80.92 per share. | 09 Jul 2025 | 240 | 60,956 | - | 80.9 | 19,421 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 79.94 per share. | 09 Jul 2025 | 5,260 | 61,196 | - | 79.9 | 420,484 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.33 per share. | 09 Jul 2025 | 4,440 | 66,456 | - | 29.3 | 130,225 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 09 Jul 2025 | 878 | 62,016 | - | 27.8 | 24,452 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 09 Jul 2025 | 182 | 61,138 | - | 18.9 | 3,445 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 81.90 per share. | 09 Jul 2025 | 200 | 60,956 | - | 81.9 | 16,380 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 80.02 per share. | 27 Jun 2025 | 20,000 | 61,734 | - | 80.0 | 1,600,400 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 27 Jun 2025 | 20,000 | 81,734 | - | 18.9 | 378,600 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jun 2025 | 20,000 | 87,000 | - | - | Stock Option (Right to Buy) | |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 26 Jun 2025 | 4,000 | 52,034 | - | 27.9 | 111,400 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Jun 2025 | 4,000 | 138,329 | - | - | Stock Option (Right to Buy) | |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 79.15 per share. | 26 Jun 2025 | 306 | 48,034 | - | 79.2 | 24,220 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 78.70 per share. | 26 Jun 2025 | 3,609 | 48,340 | - | 78.7 | 284,028 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 77.38 per share. | 26 Jun 2025 | 85 | 51,949 | - | 77.4 | 6,577 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 79.92 per share. | 25 Jun 2025 | 2,170 | 63,101 | - | 79.9 | 173,426 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.33 per share. | 25 Jun 2025 | 1,823 | 65,271 | - | 29.3 | 53,469 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 25 Jun 2025 | 347 | 63,448 | - | 27.9 | 9,664 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 79.87 per share. | 25 Jun 2025 | 8,630 | 63,101 | - | 79.9 | 689,278 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 25 Jun 2025 | 3,677 | 66,778 | - | 27.8 | 102,404 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.33 per share. | 25 Jun 2025 | 4,953 | 71,731 | - | 29.3 | 145,271 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2025 | 1,823 | 25,299 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2025 | 347 | 28,328 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2025 | 4,953 | 27,122 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2025 | 3,677 | 28,675 | - | - | Stock Option (Right to Buy) | |
| Anna Protopapas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2025 | 4,147 | 4,147 | - | - | Stock Option (Right to Buy) | |
| Anna Protopapas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2025 | 2,647 | 5,146 | - | 0 | Class A Common Stock | |
| Sapna Srivastava | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2025 | 4,147 | 4,147 | - | - | Stock Option (Right to Buy) | |
| Sapna Srivastava | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2025 | 2,647 | 5,146 | - | 0 | Class A Common Stock | |
| Grant C. Bogle | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2025 | 4,147 | 4,147 | - | - | Stock Option (Right to Buy) | |
| Grant C. Bogle | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2025 | 2,647 | 5,847 | - | 0 | Class A Common Stock | |
| Michael L. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2025 | 4,147 | 4,147 | - | - | Stock Option (Right to Buy) | |
| Michael L. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2025 | 2,647 | 5,146 | - | 0 | Class A Common Stock | |
| Cameron A. Wheeler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2025 | 4,147 | 4,147 | - | - | Stock Option (Right to Buy) | |
| Cameron A. Wheeler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2025 | 2,647 | 5,146 | - | 0 | Class A Common Stock | |
| Joseph Pearlberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2025 | 4,147 | 4,147 | - | - | Stock Option (Right to Buy) | |
| Joseph Pearlberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2025 | 2,647 | 5,146 | - | 0 | Class A Common Stock | |
| Matthew Shair | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2025 | 4,147 | 4,147 | - | - | Stock Option (Right to Buy) | |
| Matthew Shair | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2025 | 2,647 | 1,429,844 | - | 0 | Class A Common Stock | |
| Christy J. Oliger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2025 | 3,971 | 3,971 | - | 0 | Class A Common Stock | |
| Christy J. Oliger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2025 | 6,119 | 6,119 | - | - | Stock Option (Right to Buy) | |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 16 Jun 2025 | 27,000 | 276,062 | - | 27.9 | 751,950 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2025 | 27,000 | 177,780 | - | - | Stock Option (Right to Buy) | |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 78.22 per share. | 16 Jun 2025 | 200 | 249,062 | - | 78.2 | 15,644 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 77.26 per share. | 16 Jun 2025 | 11,601 | 249,262 | - | 77.3 | 896,293 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 76.66 per share. | 16 Jun 2025 | 15,199 | 260,863 | - | 76.7 | 1,165,155 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jun 2025 | 100 | 32,352 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jun 2025 | 100 | 32,075 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 79.82 per share. | 06 Jun 2025 | 200 | 63,101 | - | 79.8 | 15,964 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.33 per share. | 06 Jun 2025 | 100 | 63,301 | - | 29.3 | 2,933 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 06 Jun 2025 | 100 | 63,201 | - | 27.9 | 2,785 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.40 per share. | 29 May 2025 | 2,129 | 50,163 | - | 14.4 | 30,658 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 71.67 per share. | 29 May 2025 | 563 | 48,034 | - | 71.7 | 40,350 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 May 2025 | 2,129 | 21,259 | - | - | Stock Option (Right to Buy) | |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 May 2025 | 1,871 | 142,329 | - | - | Stock Option (Right to Buy) | |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 71.25 per share. | 29 May 2025 | 3,437 | 48,597 | - | 71.2 | 244,886 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 29 May 2025 | 1,871 | 52,034 | - | 27.8 | 52,107 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 15 May 2025 | 27,000 | 276,062 | - | 27.9 | 751,950 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 May 2025 | 27,000 | 204,780 | - | - | Stock Option (Right to Buy) | |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 70.77 per share. | 15 May 2025 | 335 | 249,062 | - | 70.8 | 23,708 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 69.99 per share. | 15 May 2025 | 11,489 | 249,397 | - | 70.0 | 804,115 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 69.28 per share. | 15 May 2025 | 15,176 | 260,886 | - | 69.3 | 1,051,393 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.40 per share. | 29 Apr 2025 | 4,000 | 52,034 | - | 14.4 | 57,600 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Apr 2025 | 4,000 | 23,388 | - | - | Stock Option (Right to Buy) | |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 74.56 per share. | 29 Apr 2025 | 4,000 | 48,034 | - | 74.6 | 298,240 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 70.05 per share. | 15 Apr 2025 | 4,465 | 249,550 | - | 70.0 | 312,773 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 69.05 per share. | 15 Apr 2025 | 11,060 | 254,015 | - | 69.1 | 763,693 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 68.31 per share. | 15 Apr 2025 | 10,987 | 265,075 | - | 68.3 | 750,522 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 15 Apr 2025 | 27,000 | 276,062 | - | 27.9 | 751,950 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2025 | 27,000 | 231,780 | - | - | Stock Option (Right to Buy) | |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 70.73 per share. | 15 Apr 2025 | 488 | 249,062 | - | 70.7 | 34,516 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 27 Mar 2025 | 2,227 | 50,261 | - | 18.9 | 42,157 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Mar 2025 | 1,773 | 27,388 | - | - | Stock Option (Right to Buy) | |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Mar 2025 | 2,227 | 33,573 | - | - | Stock Option (Right to Buy) | |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 73.83 per share. | 27 Mar 2025 | 900 | 48,034 | - | 73.8 | 66,447 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 72.91 per share. | 27 Mar 2025 | 3,100 | 48,934 | - | 72.9 | 226,021 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.40 per share. | 27 Mar 2025 | 1,773 | 52,034 | - | 14.4 | 25,531 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 76.69 per share. | 17 Mar 2025 | 601 | 249,062 | - | 76.7 | 46,091 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 76.20 per share. | 17 Mar 2025 | 16,363 | 249,663 | - | 76.2 | 1,246,861 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 75.29 per share. | 17 Mar 2025 | 10,036 | 266,026 | - | 75.3 | 755,610 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 17 Mar 2025 | 27,000 | 276,062 | - | 27.9 | 751,950 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Mar 2025 | 27,000 | 258,780 | - | - | Stock Option (Right to Buy) | |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.08 per share. | 06 Mar 2025 | 21,985 | 70,019 | - | 1.1 | 23,744 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2025 | 4,000 | 10,216 | - | - | Stock Option (Right to Buy) | |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2025 | 8,015 | 6,776 | - | - | Stock Option (Right to Buy) | |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2025 | 21,985 | 14,216 | - | - | Stock Option (Right to Buy) | |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 72.59 per share. | 06 Mar 2025 | 1,100 | 48,034 | - | 72.6 | 79,849 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 71.68 per share. | 06 Mar 2025 | 2,900 | 49,134 | - | 71.7 | 207,872 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.08 per share. | 06 Mar 2025 | 4,000 | 52,034 | - | 1.1 | 4,320 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 72.60 per share. | 06 Mar 2025 | 4,306 | 48,034 | - | 72.6 | 312,616 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 71.92 per share. | 06 Mar 2025 | 22,016 | 52,340 | - | 71.9 | 1,583,391 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 70.65 per share. | 06 Mar 2025 | 3,678 | 74,356 | - | 70.7 | 259,851 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.89 per share. | 06 Mar 2025 | 8,015 | 78,034 | - | 6.9 | 55,223 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 78.49 per share. | 24 Feb 2025 | 1,382 | 216,824 | - | 78.5 | 108,473 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 79.13 per share. | 24 Feb 2025 | 302 | 216,522 | - | 79.1 | 23,897 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 77.51 per share. | 24 Feb 2025 | 316 | 218,206 | - | 77.5 | 24,493 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 79.01 per share. | 18 Feb 2025 | 800 | 249,062 | - | 79.0 | 63,208 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 78.44 per share. | 18 Feb 2025 | 26,200 | 249,862 | - | 78.4 | 2,055,128 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 18 Feb 2025 | 27,000 | 276,062 | - | 27.9 | 751,950 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2025 | 27,000 | 285,780 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 3,120 | 2,007 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.87 per share. | 31 Jan 2025 | 3,120 | 63,101 | - | 0.9 | 2,714 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 82.24 per share. | 27 Jan 2025 | 1,040 | 219,482 | - | 82.2 | 85,530 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 82.91 per share. | 27 Jan 2025 | 618 | 218,864 | - | 82.9 | 51,238 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 83.88 per share. | 27 Jan 2025 | 234 | 218,630 | - | 83.9 | 19,628 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 85.00 per share. | 27 Jan 2025 | 108 | 218,522 | - | 85 | 9,180 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 77.28 per share. | 15 Jan 2025 | 5,842 | 249,062 | - | 77.3 | 451,470 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 76.65 per share. | 15 Jan 2025 | 5,493 | 254,904 | - | 76.6 | 421,038 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 75.51 per share. | 15 Jan 2025 | 9,358 | 260,397 | - | 75.5 | 706,623 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 74.94 per share. | 15 Jan 2025 | 6,307 | 269,755 | - | 74.9 | 472,647 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 15 Jan 2025 | 27,000 | 276,062 | - | 27.9 | 751,950 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 27,000 | 312,780 | - | - | Stock Option (Right to Buy) | |
| James R. Porter | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 112,500 | 112,500 | - | - | Stock Option (Right to Buy) | |
| James R. Porter | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 56,250 | 266,363 | - | 0 | Class A Common Stock | |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 78.28 per share. | 06 Jan 2025 | 4,962 | 261,401 | - | 78.3 | 388,425 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 79.33 per share. | 06 Jan 2025 | 2,979 | 258,422 | - | 79.3 | 236,324 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 80.54 per share. | 06 Jan 2025 | 9,360 | 249,062 | - | 80.5 | 753,854 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 18,750 | 65,750 | - | 0 | Class A Common Stock | |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 78.28 per share. | 06 Jan 2025 | 1,152 | 64,598 | - | 78.3 | 90,179 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 79.33 per share. | 06 Jan 2025 | 691 | 63,907 | - | 79.3 | 54,817 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 80.54 per share. | 06 Jan 2025 | 2,173 | 61,734 | - | 80.5 | 175,013 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 37,500 | 37,500 | - | - | Stock Option (Right to Buy) | |
| Christopher D. Turner | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 37,500 | 37,500 | - | - | Stock Option (Right to Buy) | |
| Christopher D. Turner | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 18,750 | 66,563 | - | 0 | Class A Common Stock | |
| Christopher D. Turner | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 78.28 per share. | 06 Jan 2025 | 1,152 | 65,411 | - | 78.3 | 90,179 | Class A Common Stock |
| Christopher D. Turner | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 79.33 per share. | 06 Jan 2025 | 691 | 64,720 | - | 79.3 | 54,817 | Class A Common Stock |
| Christopher D. Turner | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 80.54 per share. | 06 Jan 2025 | 2,173 | 62,547 | - | 80.5 | 175,013 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 37,500 | 37,500 | - | - | Stock Option (Right to Buy) | |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 80.54 per share. | 06 Jan 2025 | 1,604 | 49,086 | - | 80.5 | 129,186 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 79.33 per share. | 06 Jan 2025 | 510 | 50,690 | - | 79.3 | 40,458 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 78.28 per share. | 06 Jan 2025 | 850 | 51,200 | - | 78.3 | 66,538 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 18,750 | 52,050 | - | 0 | Class A Common Stock | |
| Darlene Noci | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 18,750 | 52,050 | - | 0 | Class A Common Stock | |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 78.28 per share. | 06 Jan 2025 | 1,152 | 50,898 | - | 78.3 | 90,179 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 79.33 per share. | 06 Jan 2025 | 691 | 50,207 | - | 79.3 | 54,817 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 80.54 per share. | 06 Jan 2025 | 2,173 | 48,034 | - | 80.5 | 175,013 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 37,500 | 37,500 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 37,500 | 37,500 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 80.54 per share. | 06 Jan 2025 | 1,343 | 59,981 | - | 80.5 | 108,165 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 79.33 per share. | 06 Jan 2025 | 428 | 61,324 | - | 79.3 | 33,953 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 78.28 per share. | 06 Jan 2025 | 712 | 61,752 | - | 78.3 | 55,735 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 18,750 | 62,464 | - | 0 | Class A Common Stock | |
| Shair Matthew | Director | Sale of securities on an exchange or to another person at price $ 83.62 per share. | 23 Dec 2024 | 1,409 | 221,113 | - | 83.6 | 117,821 | Class A Common Stock |
| Shair Matthew | Director | Sale of securities on an exchange or to another person at price $ 84.17 per share. | 23 Dec 2024 | 591 | 220,522 | - | 84.2 | 49,744 | Class A Common Stock |
| Porter James R. | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.65 per share. | 19 Dec 2024 | 22,000 | 210,113 | - | 0.7 | 14,300 | Class A Common Stock |
| James Porter R. | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Dec 2024 | 22,000 | 565,942 | - | - | Stock Option (Right to Buy) | |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.08 per share. | 17 Dec 2024 | 4,728 | 38,028 | - | 1.1 | 5,106 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Dec 2024 | 4,728 | 196,156 | - | - | Stock Option (Right to Buy) | |
| Balcom Alexandra | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.89 per share. | 17 Dec 2024 | 8,972 | 47,000 | - | 6.9 | 61,817 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Dec 2024 | 8,972 | 87,226 | - | - | Stock Option (Right to Buy) | |
| Pelish Henry E. | Chief Scientific Officer | 16 Dec 2024 | 5,914 | 39,214 | - | 0.6 | 3,844 | Class A Common Stock | |
| E. Henry Pelish | Chief Scientific Officer | 16 Dec 2024 | 4,500 | 43,714 | - | 0.9 | 3,915 | Class A Common Stock | |
| E. Henry Pelish | Chief Scientific Officer | 16 Dec 2024 | 4,500 | 5,127 | - | - | Stock Option (Right to Buy) | ||
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Dec 2024 | 27,000 | 339,780 | - | - | Stock Option (Right to Buy) | |
| R. James Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 16 Dec 2024 | 27,000 | 215,113 | - | 27.9 | 751,950 | Class A Common Stock |
| Pelish Henry E. | Chief Scientific Officer | 16 Dec 2024 | 5,914 | 0 | - | - | Stock Option (Right to Buy) | ||
| R. Porter James | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 86.96 per share. | 16 Dec 2024 | 8,031 | 188,113 | - | 87.0 | 698,376 | Class A Common Stock |
| James Porter R. | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 86.46 per share. | 16 Dec 2024 | 18,969 | 196,144 | - | 86.5 | 1,640,060 | Class A Common Stock |
| Hack A. F. Andrew | Director | Sale of securities on an exchange or to another person at price $ 88.00 per share. | 11 Dec 2024 | 1,250,000 | 1,447,267 | - | 88 | 110,000,000 | Class A Common Stock |
| Grant C. Bogle | Director | 05 Dec 2024 | 4,851 | 4,851 | - | - | Stock Option (Right to Buy) | ||
| Bogle C. Grant | Director | 05 Dec 2024 | 3,200 | 3,200 | - | 0 | Class A Common Stock | ||
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 96.25 per share. | 29 Nov 2024 | 1,858 | 33,300 | - | 96.3 | 178,833 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 95.69 per share. | 29 Nov 2024 | 8,142 | 35,158 | - | 95.7 | 779,108 | Class A Common Stock |
| Balcom Alexandra | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 29 Nov 2024 | 10,000 | 43,300 | - | 27.9 | 278,500 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Nov 2024 | 10,000 | 84,200 | - | - | Stock Option (Right to Buy) | |
| Shair Matthew | Director | Sale of securities on an exchange or to another person at price $ 96.69 per share. | 25 Nov 2024 | 992 | 222,552 | - | 96.7 | 95,916 | Class A Common Stock |
| Shair Matthew | Director | Sale of securities on an exchange or to another person at price $ 95.71 per share. | 25 Nov 2024 | 978 | 223,544 | - | 95.7 | 93,604 | Class A Common Stock |
| Shair Matthew | Director | Sale of securities on an exchange or to another person at price $ 97.40 per share. | 25 Nov 2024 | 30 | 222,522 | - | 97.4 | 2,922 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 15 Nov 2024 | 27,000 | 215,113 | - | 27.9 | 751,950 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 87.95 per share. | 15 Nov 2024 | 6,068 | 197,502 | - | 88.0 | 533,681 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 88.87 per share. | 15 Nov 2024 | 8,278 | 189,224 | - | 88.9 | 735,666 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 89.98 per share. | 15 Nov 2024 | 1,111 | 188,113 | - | 90.0 | 99,968 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Nov 2024 | 27,000 | 366,780 | - | - | Stock Option (Right to Buy) | |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 87.08 per share. | 15 Nov 2024 | 11,543 | 203,570 | - | 87.1 | 1,005,164 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 87.99 per share. | 01 Nov 2024 | 1,987 | 36,313 | - | 88.0 | 174,836 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.40 per share. | 01 Nov 2024 | 5,000 | 38,300 | - | 14.4 | 72,000 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2024 | 5,000 | 29,161 | - | - | Stock Option (Right to Buy) | |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 90.03 per share. | 01 Nov 2024 | 500 | 33,300 | - | 90.0 | 45,015 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 88.79 per share. | 01 Nov 2024 | 2,513 | 33,800 | - | 88.8 | 223,129 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 88.25 per share. | 31 Oct 2024 | 1,980 | 41,320 | - | 88.3 | 174,735 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 31 Oct 2024 | 10,000 | 43,300 | - | 27.9 | 278,500 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Oct 2024 | 10,000 | 94,200 | - | - | Stock Option (Right to Buy) | |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 90.94 per share. | 31 Oct 2024 | 100 | 33,300 | - | 90.9 | 9,094 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 90.31 per share. | 31 Oct 2024 | 1,600 | 33,400 | - | 90.3 | 144,496 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 89.17 per share. | 31 Oct 2024 | 6,320 | 35,000 | - | 89.2 | 563,554 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 91.31 per share. | 28 Oct 2024 | 1,181 | 225,341 | - | 91.3 | 107,837 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 93.11 per share. | 28 Oct 2024 | 73 | 224,522 | - | 93.1 | 6,797 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 92.27 per share. | 28 Oct 2024 | 746 | 224,595 | - | 92.3 | 68,833 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 102.26 per share. | 15 Oct 2024 | 26,186 | 188,927 | - | 102.3 | 2,677,780 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 103.01 per share. | 15 Oct 2024 | 814 | 188,113 | - | 103.0 | 83,850 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 15 Oct 2024 | 27,000 | 215,113 | - | 27.9 | 751,950 | Class A Common Stock |
| James R. Porter | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2024 | 27,000 | 393,780 | - | - | Stock Option (Right to Buy) | |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2024 | 5,000 | 35,800 | - | - | Stock Option (Right to Buy) | |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 01 Oct 2024 | 5,000 | 38,300 | - | 18.9 | 94,650 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 99.93 per share. | 01 Oct 2024 | 1,200 | 37,100 | - | 99.9 | 119,916 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 100.86 per share. | 01 Oct 2024 | 796 | 36,304 | - | 100.9 | 80,285 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 101.73 per share. | 01 Oct 2024 | 1,300 | 35,004 | - | 101.7 | 132,249 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 103.08 per share. | 01 Oct 2024 | 1,125 | 33,879 | - | 103.1 | 115,965 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 103.92 per share. | 01 Oct 2024 | 405 | 33,474 | - | 103.9 | 42,088 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 104.69 per share. | 01 Oct 2024 | 174 | 33,300 | - | 104.7 | 18,216 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 98.88 per share. | 30 Sep 2024 | 700 | 42,600 | - | 98.9 | 69,216 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Sep 2024 | 10,000 | 104,200 | - | - | Stock Option (Right to Buy) | |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 101.89 per share. | 30 Sep 2024 | 2,963 | 33,300 | - | 101.9 | 301,900 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 101.13 per share. | 30 Sep 2024 | 5,032 | 36,263 | - | 101.1 | 508,886 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 100.09 per share. | 30 Sep 2024 | 1,305 | 41,295 | - | 100.1 | 130,617 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 30 Sep 2024 | 10,000 | 43,300 | - | 27.9 | 278,500 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 101.34 per share. | 23 Sep 2024 | 356 | 228,166 | - | 101.3 | 36,077 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 106.50 per share. | 23 Sep 2024 | 6 | 226,545 | - | 106.5 | 639 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 107.83 per share. | 23 Sep 2024 | 23 | 226,522 | - | 107.8 | 2,480 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 105.36 per share. | 23 Sep 2024 | 163 | 226,551 | - | 105.4 | 17,174 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 104.54 per share. | 23 Sep 2024 | 230 | 226,714 | - | 104.5 | 24,044 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 103.16 per share. | 23 Sep 2024 | 101 | 226,944 | - | 103.2 | 10,419 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 102.29 per share. | 23 Sep 2024 | 1,121 | 227,045 | - | 102.3 | 114,667 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 16 Sep 2024 | 8,000 | 41,300 | - | 18.9 | 151,440 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Sep 2024 | 8,000 | 71,000 | - | - | Stock Option (Right to Buy) | |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 102.00 per share. | 16 Sep 2024 | 300 | 33,300 | - | 102 | 30,600 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 100.08 per share. | 16 Sep 2024 | 145 | 33,600 | - | 100.1 | 14,512 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 98.34 per share. | 16 Sep 2024 | 534 | 33,745 | - | 98.3 | 52,514 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 97.30 per share. | 16 Sep 2024 | 2,297 | 34,279 | - | 97.3 | 223,498 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 96.43 per share. | 16 Sep 2024 | 2,255 | 36,576 | - | 96.4 | 217,450 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 94.86 per share. | 16 Sep 2024 | 1,869 | 38,831 | - | 94.9 | 177,293 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 93.22 per share. | 16 Sep 2024 | 600 | 40,700 | - | 93.2 | 55,932 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | 16 Sep 2024 | 3,754 | 60,375 | - | 94.8 | 355,879 | Class A Common Stock | |
| Henry E. Pelish | Chief Scientific Officer | 16 Sep 2024 | 1,966 | 64,129 | - | 93.3 | 183,330 | Class A Common Stock | |
| Henry E. Pelish | Chief Scientific Officer | 16 Sep 2024 | 7,812 | 33,400 | - | 102.5 | 801,042 | Class A Common Stock | |
| Henry E. Pelish | Chief Scientific Officer | 16 Sep 2024 | 100 | 33,300 | - | 102.8 | 10,280 | Class A Common Stock | |
| Henry E. Pelish | Chief Scientific Officer | 16 Sep 2024 | 5,513 | 41,212 | - | 101.2 | 557,805 | Class A Common Stock | |
| Henry E. Pelish | Chief Scientific Officer | 16 Sep 2024 | 4,094 | 46,725 | - | 100.3 | 410,424 | Class A Common Stock | |
| Henry E. Pelish | Chief Scientific Officer | 16 Sep 2024 | 706 | 50,819 | - | 98.2 | 69,343 | Class A Common Stock | |
| Henry E. Pelish | Chief Scientific Officer | 16 Sep 2024 | 3,197 | 51,525 | - | 97.5 | 311,835 | Class A Common Stock | |
| Henry E. Pelish | Chief Scientific Officer | 16 Sep 2024 | 4,105 | 54,722 | - | 96.6 | 396,584 | Class A Common Stock | |
| Henry E. Pelish | Chief Scientific Officer | 16 Sep 2024 | 1,548 | 58,827 | - | 95.4 | 147,617 | Class A Common Stock | |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.89 per share. | 09 Sep 2024 | 3,000 | 36,300 | - | 6.9 | 20,670 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Sep 2024 | 3,000 | 173,608 | - | - | Stock Option (Right to Buy) | |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 89.11 per share. | 09 Sep 2024 | 161 | 33,300 | - | 89.1 | 14,347 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 88.37 per share. | 09 Sep 2024 | 2,311 | 33,461 | - | 88.4 | 204,223 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 87.69 per share. | 09 Sep 2024 | 288 | 35,772 | - | 87.7 | 25,255 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 86.34 per share. | 09 Sep 2024 | 240 | 36,060 | - | 86.3 | 20,722 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 03 Sep 2024 | 5,000 | 38,300 | - | 18.9 | 94,650 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2024 | 5,000 | 40,800 | - | - | Stock Option (Right to Buy) | |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 85.64 per share. | 03 Sep 2024 | 512 | 33,300 | - | 85.6 | 43,848 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 84.56 per share. | 03 Sep 2024 | 2,510 | 33,812 | - | 84.6 | 212,246 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 83.95 per share. | 03 Sep 2024 | 1,978 | 36,322 | - | 83.9 | 166,053 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 83.87 per share. | 30 Aug 2024 | 5,231 | 38,069 | - | 83.9 | 438,724 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Aug 2024 | 10,000 | 114,200 | - | - | Stock Option (Right to Buy) | |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 85.96 per share. | 30 Aug 2024 | 288 | 33,300 | - | 86.0 | 24,756 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 84.55 per share. | 30 Aug 2024 | 4,481 | 33,588 | - | 84.6 | 378,869 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 30 Aug 2024 | 10,000 | 43,300 | - | 27.9 | 278,500 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 85.53 per share. | 26 Aug 2024 | 156 | 228,522 | - | 85.5 | 13,343 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 84.79 per share. | 26 Aug 2024 | 1,047 | 228,678 | - | 84.8 | 88,775 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 83.81 per share. | 26 Aug 2024 | 797 | 229,725 | - | 83.8 | 66,797 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 23 Aug 2024 | 5,000 | 38,300 | - | 18.9 | 94,650 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 23 Aug 2024 | 6,000 | 44,300 | - | 27.9 | 167,100 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2024 | 6,000 | 90,154 | - | - | Stock Option (Right to Buy) | |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2024 | 5,000 | 79,000 | - | - | Stock Option (Right to Buy) | |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 85.04 per share. | 23 Aug 2024 | 11,000 | 33,300 | - | 85.0 | 935,440 | Class A Common Stock |
| Emily Drabant Conley | Director | Sale of securities on an exchange or to another person at price $ 85.02 per share. | 23 Aug 2024 | 3,334 | 2,507 | - | 85.0 | 283,457 | Class A Common Stock |
| Emily Drabant Conley | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.79 per share. | 23 Aug 2024 | 3,334 | 5,841 | - | 13.8 | 45,976 | Class A Common Stock |
| Emily Drabant Conley | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2024 | 3,334 | 23,333 | - | - | Stock Option (Right to Buy) | |
| Henry E. Pelish | Chief Scientific Officer | 23 Aug 2024 | 10,500 | 66,095 | - | 85.1 | 893,340 | Class A Common Stock | |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 67.17 per share. | 08 Aug 2024 | 624 | 35,564 | - | 67.2 | 41,914 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 65.66 per share. | 08 Aug 2024 | 112 | 36,188 | - | 65.7 | 7,354 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.89 per share. | 08 Aug 2024 | 3,000 | 36,300 | - | 6.9 | 20,670 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 69.95 per share. | 08 Aug 2024 | 374 | 33,300 | - | 69.9 | 26,161 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Aug 2024 | 3,000 | 176,608 | - | - | Stock Option (Right to Buy) | |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 69.34 per share. | 08 Aug 2024 | 1,794 | 33,674 | - | 69.3 | 124,396 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 67.95 per share. | 08 Aug 2024 | 96 | 35,468 | - | 67.9 | 6,523 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 01 Aug 2024 | 5,000 | 38,300 | - | 18.9 | 94,650 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2024 | 5,000 | 45,800 | - | - | Stock Option (Right to Buy) | |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 80.32 per share. | 01 Aug 2024 | 63 | 33,300 | - | 80.3 | 5,060 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 79.22 per share. | 01 Aug 2024 | 189 | 33,363 | - | 79.2 | 14,973 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 78.33 per share. | 01 Aug 2024 | 933 | 33,552 | - | 78.3 | 73,082 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 77.36 per share. | 01 Aug 2024 | 1,957 | 34,485 | - | 77.4 | 151,394 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 76.22 per share. | 01 Aug 2024 | 1,858 | 36,442 | - | 76.2 | 141,617 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 77.02 per share. | 31 Jul 2024 | 896 | 42,404 | - | 77.0 | 69,010 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jul 2024 | 10,000 | 124,200 | - | - | Stock Option (Right to Buy) | |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 81.31 per share. | 31 Jul 2024 | 1,135 | 33,300 | - | 81.3 | 92,287 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 80.38 per share. | 31 Jul 2024 | 1,649 | 34,435 | - | 80.4 | 132,547 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 79.44 per share. | 31 Jul 2024 | 5,723 | 36,084 | - | 79.4 | 454,635 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 78.05 per share. | 31 Jul 2024 | 597 | 41,807 | - | 78.1 | 46,596 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 31 Jul 2024 | 10,000 | 43,300 | - | 27.9 | 278,500 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 78.93 per share. | 29 Jul 2024 | 1,200 | 231,322 | - | 78.9 | 94,716 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 81.71 per share. | 29 Jul 2024 | 91 | 230,522 | - | 81.7 | 7,436 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 80.98 per share. | 29 Jul 2024 | 404 | 230,613 | - | 81.0 | 32,716 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 79.70 per share. | 29 Jul 2024 | 305 | 231,017 | - | 79.7 | 24,309 | Class A Common Stock |
| Emily Drabant Conley | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 5,000 | 26,667 | - | - | Stock Option (Right to Buy) | |
| Emily Drabant Conley | Director | Sale of securities on an exchange or to another person at price $ 80.29 per share. | 15 Jul 2024 | 1,900 | 4,907 | - | 80.3 | 152,551 | Class A Common Stock |
| Emily Drabant Conley | Director | Sale of securities on an exchange or to another person at price $ 79.43 per share. | 15 Jul 2024 | 700 | 6,807 | - | 79.4 | 55,601 | Class A Common Stock |
| Emily Drabant Conley | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.79 per share. | 15 Jul 2024 | 5,000 | 7,507 | - | 13.8 | 68,950 | Class A Common Stock |
| Emily Drabant Conley | Director | Sale of securities on an exchange or to another person at price $ 81.93 per share. | 15 Jul 2024 | 205 | 2,507 | - | 81.9 | 16,796 | Class A Common Stock |
| Emily Drabant Conley | Director | Sale of securities on an exchange or to another person at price $ 81.40 per share. | 15 Jul 2024 | 2,195 | 2,712 | - | 81.4 | 178,673 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jul 2024 | 6,000 | 96,154 | - | - | Stock Option (Right to Buy) | |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 12 Jul 2024 | 6,000 | 39,300 | - | 27.9 | 167,100 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 80.16 per share. | 12 Jul 2024 | 6,000 | 33,300 | - | 80.2 | 480,960 | Class A Common Stock |
| Henry E. Pelish | Chief Scientific Officer | 09 Jul 2024 | 13,100 | 76,595 | - | 0 | Class A Common Stock | ||
| Henry E. Pelish | Chief Scientific Officer | 09 Jul 2024 | 18,600 | 18,600 | - | - | Stock Option (Right to Buy) | ||
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.89 per share. | 08 Jul 2024 | 3,000 | 36,300 | - | 6.9 | 20,670 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jul 2024 | 3,000 | 179,608 | - | - | Stock Option (Right to Buy) | |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 73.84 per share. | 08 Jul 2024 | 699 | 33,300 | - | 73.8 | 51,614 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 73.39 per share. | 08 Jul 2024 | 1,739 | 33,999 | - | 73.4 | 127,625 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 71.97 per share. | 08 Jul 2024 | 562 | 35,738 | - | 72.0 | 40,447 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.46 per share. | 01 Jul 2024 | 4,458 | 33,842 | - | 75.5 | 336,401 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2024 | 5,000 | 50,800 | - | - | Stock Option (Right to Buy) | |
| Darlene Noci | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 01 Jul 2024 | 5,000 | 38,300 | - | 18.9 | 94,650 | Class A Common Stock |
| Darlene Noci | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 76.19 per share. | 01 Jul 2024 | 542 | 33,300 | - | 76.2 | 41,295 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.85 per share. | 28 Jun 2024 | 10,000 | 43,300 | - | 27.9 | 278,500 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Jun 2024 | 10,000 | 134,200 | - | - | Stock Option (Right to Buy) | |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 76.73 per share. | 28 Jun 2024 | 572 | 33,300 | - | 76.7 | 43,890 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 76.19 per share. | 28 Jun 2024 | 1,863 | 33,872 | - | 76.2 | 141,942 | Class A Common Stock |
| Alexandra Balcom | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 75.15 per share. | 28 Jun 2024 | 7,565 | 35,735 | - | 75.2 | 568,510 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 79.47 per share. | 24 Jun 2024 | 634 | 233,888 | - | 79.5 | 50,384 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 80.50 per share. | 24 Jun 2024 | 1,176 | 232,712 | - | 80.5 | 94,668 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 80.98 per share. | 24 Jun 2024 | 190 | 232,522 | - | 81.0 | 15,386 | Class A Common Stock |
| Emily Drabant Conley | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.79 per share. | 14 Jun 2024 | 5,000 | 7,507 | - | 13.8 | 68,950 | Class A Common Stock |
| Emily Drabant Conley | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jun 2024 | 5,000 | 31,667 | - | - | Stock Option (Right to Buy) | |
| Emily Drabant Conley | Director | Sale of securities on an exchange or to another person at price $ 78.31 per share. | 14 Jun 2024 | 223 | 2,507 | - | 78.3 | 17,463 | Class A Common Stock |
| Emily Drabant Conley | Director | Sale of securities on an exchange or to another person at price $ 77.52 per share. | 14 Jun 2024 | 4,777 | 2,730 | - | 77.5 | 370,313 | Class A Common Stock |
| Anna Protopapas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 2,499 | 2,499 | - | 0 | Class A Common Stock | |
| Anna Protopapas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 3,789 | 3,789 | - | - | Stock Option (Right to Buy) | |
| Sapna Srivastava | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 2,499 | 2,499 | - | 0 | Class A Common Stock | |
| Sapna Srivastava | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 3,789 | 3,789 | - | - | Stock Option (Right to Buy) | |
| D. Gary Gilliland | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 2,499 | 2,499 | - | 0 | Class A Common Stock | |
| D. Gary Gilliland | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 3,789 | 3,789 | - | - | Stock Option (Right to Buy) | |
| Michael L. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 3,789 | 3,789 | - | - | Stock Option (Right to Buy) | |
| Michael L. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 2,499 | 2,499 | - | 0 | Class A Common Stock | |
| Cameron A. Wheeler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 2,499 | 2,499 | - | 0 | Class A Common Stock | |
| Cameron A. Wheeler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 3,789 | 3,789 | - | - | Stock Option (Right to Buy) | |
| Joseph Pearlberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 2,499 | 2,499 | - | 0 | Class A Common Stock | |
| Joseph Pearlberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 3,789 | 3,789 | - | - | Stock Option (Right to Buy) | |
| Matthew Shair | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 2,499 | 1,427,197 | - | 0 | Class A Common Stock | |
| Matthew Shair | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 3,789 | 3,789 | - | - | Stock Option (Right to Buy) | |
| Emily Drabant Conley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 3,789 | 3,789 | - | - | Stock Option (Right to Buy) | |
| Emily Drabant Conley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 2,499 | 2,507 | - | 0 | Class A Common Stock | |
| Andrew A. F. Hack | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 2,499 | 2,499 | - | - | Class A Common Stock | |
| Andrew A. F. Hack | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 3,789 | 3,789 | - | - | Stock Option (right to buy) | |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.89 per share. | 06 Jun 2024 | 3,000 | 36,300 | - | 6.9 | 20,670 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jun 2024 | 5,000 | 84,000 | - | - | Stock Option (Right to Buy) | |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jun 2024 | 3,000 | 182,608 | - | - | Stock Option (Right to Buy) | |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 82.33 per share. | 06 Jun 2024 | 1,566 | 33,300 | - | 82.3 | 128,929 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 82.05 per share. | 06 Jun 2024 | 3,884 | 34,866 | - | 82.0 | 318,682 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 80.43 per share. | 06 Jun 2024 | 199 | 38,750 | - | 80.4 | 16,006 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 79.69 per share. | 06 Jun 2024 | 541 | 38,949 | - | 79.7 | 43,112 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 77.97 per share. | 06 Jun 2024 | 148 | 39,490 | - | 78.0 | 11,540 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 76.88 per share. | 06 Jun 2024 | 526 | 39,638 | - | 76.9 | 40,439 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 75.81 per share. | 06 Jun 2024 | 156 | 40,164 | - | 75.8 | 11,826 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 74.39 per share. | 06 Jun 2024 | 750 | 40,320 | - | 74.4 | 55,793 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 73.42 per share. | 06 Jun 2024 | 230 | 41,070 | - | 73.4 | 16,887 | Class A Common Stock |
| Deborah Miller | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.93 per share. | 06 Jun 2024 | 5,000 | 41,300 | - | 18.9 | 94,650 | Class A Common Stock |
| Matthew Shair | Director | Sale of securities on an exchange or to another person at price $ 66.87 per share. | 28 May 2024 | 1,256 | 235,266 | - | 66.9 | 83,989 | Class A Common Stock |