XNAS 04 Sep, 2026 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 80.06 per share. | 02 Sep 2026 | 10,000 | 837,991 | - | 80.1 | 800,600 | Common Stock |
| Elizabeth Yeu-Lin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 80.00 per share. | 01 Sep 2026 | 1,590 | 4,770 | - | 80 | 127,200 | Common Stock |
| Elizabeth Yeu-Lin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 80.00 per share. | 01 Sep 2026 | 5,387 | 13,320 | - | 80 | 430,960 | Common Stock |
| Elizabeth Yeu-Lin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 73.86 per share. | 01 Sep 2026 | 4,601 | 18,707 | - | 73.9 | 339,830 | Common Stock |
| Wendy L. Yarno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2026 | 3,837 | 3,837 | - | - | Stock Option (right to buy) | |
| Wendy L. Yarno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2026 | 1,209 | 1,209 | - | - | Restricted Stock Units | |
| Wendy L. Yarno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2026 | 2,417 | 2,417 | - | - | Restricted Stock Units | |
| William J. Link | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2026 | 3,837 | 3,837 | - | - | Stock Option (right to buy) | |
| William J. Link | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2026 | 2,417 | 2,417 | - | - | Restricted Stock Units | |
| William J. Link | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2026 | 806 | 806 | - | - | Restricted Stock Units | |
| David E.I. Pyott | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2026 | 2,417 | 2,417 | - | - | Restricted Stock Units | |
| David E.I. Pyott | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2026 | 806 | 806 | - | - | Restricted Stock Units | |
| David E.I. Pyott | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2026 | 3,837 | 3,837 | - | - | Stock Option (right to buy) | |
| Bhaskar Chaudhuri | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2026 | 2,417 | 2,417 | - | - | Restricted Stock Units | |
| Bhaskar Chaudhuri | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2026 | 3,837 | 3,837 | - | - | Stock Option (right to buy) | |
| Andrew Goldberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2026 | 3,837 | 3,837 | - | - | Stock Option (right to buy) | |
| Andrew Goldberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2026 | 2,417 | 2,417 | - | - | Restricted Stock Units | |
| Katherine Goodrich | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2026 | 2,417 | 2,417 | - | - | Restricted Stock Units | |
| Katherine Goodrich | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2026 | 3,837 | 3,837 | - | - | Stock Option (right to buy) | |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 61.24 per share. | 17 Jun 2026 | 4,582 | 853,409 | - | 61.2 | 280,602 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 61.81 per share. | 17 Jun 2026 | 5,418 | 847,991 | - | 61.8 | 334,887 | Common Stock |
| Jeffrey S. Farrow | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jun 2026 | 27,881 | 27,882 | - | - | Restricted Stock Units | |
| Jeffrey S. Farrow | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jun 2026 | 27,881 | 71,197 | - | - | Common Stock | |
| Jeffrey S. Farrow | See Remarks | Sale of securities on an exchange or to another person at price $ 60.95 per share. | 15 Jun 2026 | 14,396 | 56,801 | - | 60.9 | 877,436 | Common Stock |
| William J. Link | Director | Sale of securities on an exchange or to another person at price $ 62.94 per share. | 15 Jun 2026 | 1,928 | 106,786 | - | 62.9 | 121,348 | Common Stock |
| William J. Link | Director | Sale of securities on an exchange or to another person at price $ 61.97 per share. | 15 Jun 2026 | 10,572 | 108,714 | - | 62.0 | 655,147 | Common Stock |
| Katherine Goodrich | Director | Sale of securities on an exchange or to another person at price $ 62.08 per share. | 15 Jun 2026 | 2,954 | 2,233 | - | 62.1 | 183,384 | Common Stock |
| Wendy L. Yarno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2026 | 2,954 | 0 | - | - | Restricted Stock Units | |
| Wendy L. Yarno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2026 | 2,954 | 16,654 | - | - | Common Stock | |
| William J. Link | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2026 | 2,954 | 0 | - | - | Restricted Stock Units | |
| William J. Link | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2026 | 2,954 | 119,286 | - | - | Common Stock | |
| Bhaskar Chaudhuri | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2026 | 2,954 | 0 | - | - | Restricted Stock Units | |
| Bhaskar Chaudhuri | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2026 | 2,954 | 11,654 | - | - | Common Stock | |
| Andrew Goldberg | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2026 | 2,954 | 19,654 | - | - | Common Stock | |
| Andrew Goldberg | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2026 | 2,954 | 0 | - | - | Restricted Stock Units | |
| Katherine Goodrich | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2026 | 2,954 | 0 | - | - | Restricted Stock Units | |
| Katherine Goodrich | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2026 | 2,954 | 5,187 | - | - | Common Stock | |
| David E.I. Pyott | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Apr 2026 | 1,383 | 1,383 | - | - | Common Stock | |
| David E.I. Pyott | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Apr 2026 | 1,383 | 0 | - | - | Restricted Stock Units | |
| Seshadri Neervannan | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 66.75 per share. | 20 Mar 2026 | 2,989 | 82,791 | - | 66.8 | 199,516 | Common Stock |
| Jeffrey S. Farrow | See Remarks | Sale of securities on an exchange or to another person at price $ 69.42 per share. | 17 Mar 2026 | 2,111 | 47,635 | - | 69.4 | 146,546 | Common Stock |
| Jeffrey S. Farrow | See Remarks | Sale of securities on an exchange or to another person at price $ 67.00 per share. | 17 Mar 2026 | 2,186 | 43,316 | - | 67 | 146,462 | Common Stock |
| Jeffrey S. Farrow | See Remarks | Sale of securities on an exchange or to another person at price $ 68.71 per share. | 17 Mar 2026 | 2,133 | 45,502 | - | 68.7 | 146,558 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 68.71 per share. | 17 Mar 2026 | 4,330 | 65,920 | - | 68.7 | 297,514 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 69.42 per share. | 17 Mar 2026 | 4,286 | 70,250 | - | 69.4 | 297,534 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 67.00 per share. | 17 Mar 2026 | 4,440 | 61,480 | - | 67 | 297,480 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 68.71 per share. | 17 Mar 2026 | 11,667 | 45,385 | - | 68.7 | 801,640 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 69.42 per share. | 17 Mar 2026 | 10,972 | 57,052 | - | 69.4 | 761,676 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 67.00 per share. | 17 Mar 2026 | 11,964 | 33,421 | - | 67 | 801,588 | Common Stock |
| Seshadri Neervannan | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 69.42 per share. | 17 Mar 2026 | 3,125 | 93,979 | - | 69.4 | 216,938 | Common Stock |
| Seshadri Neervannan | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 68.71 per share. | 17 Mar 2026 | 3,610 | 90,369 | - | 68.7 | 248,043 | Common Stock |
| Seshadri Neervannan | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 67.00 per share. | 17 Mar 2026 | 4,589 | 85,780 | - | 67 | 307,463 | Common Stock |
| Dianne C. Whitfield | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 68.71 per share. | 17 Mar 2026 | 4,071 | 39,202 | - | 68.7 | 279,718 | Common Stock |
| Dianne C. Whitfield | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 67.00 per share. | 17 Mar 2026 | 4,174 | 35,028 | - | 67 | 279,658 | Common Stock |
| Dianne C. Whitfield | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 69.42 per share. | 17 Mar 2026 | 4,029 | 43,273 | - | 69.4 | 279,693 | Common Stock |
| Bryan Wahl | General Counsel | Sale of securities on an exchange or to another person at price $ 68.71 per share. | 17 Mar 2026 | 4,125 | 68,190 | - | 68.7 | 283,429 | Common Stock |
| Bryan Wahl | General Counsel | Sale of securities on an exchange or to another person at price $ 67.00 per share. | 17 Mar 2026 | 4,231 | 63,959 | - | 67 | 283,477 | Common Stock |
| Bryan Wahl | General Counsel | Sale of securities on an exchange or to another person at price $ 69.42 per share. | 17 Mar 2026 | 4,084 | 72,315 | - | 69.4 | 283,511 | Common Stock |
| Elizabeth Yeu-Lin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 67.00 per share. | 17 Mar 2026 | 390 | 23,308 | - | 67 | 26,130 | Common Stock |
| Elizabeth Yeu-Lin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 69.42 per share. | 17 Mar 2026 | 375 | 24,077 | - | 69.4 | 26,033 | Common Stock |
| Elizabeth Yeu-Lin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 68.71 per share. | 17 Mar 2026 | 379 | 23,698 | - | 68.7 | 26,041 | Common Stock |
| William J. Link | Director | Sale of securities on an exchange or to another person at price $ 68.09 per share. | 16 Mar 2026 | 3,629 | 125,203 | - | 68.1 | 247,099 | Common Stock |
| William J. Link | Director | Sale of securities on an exchange or to another person at price $ 69.75 per share. | 16 Mar 2026 | 493 | 116,332 | - | 69.8 | 34,387 | Common Stock |
| William J. Link | Director | Sale of securities on an exchange or to another person at price $ 69.03 per share. | 16 Mar 2026 | 8,378 | 116,825 | - | 69.0 | 578,333 | Common Stock |
| Jeffrey S. Farrow | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 8,020 | 16,040 | - | - | Restricted Stock Units | |
| Jeffrey S. Farrow | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 5,022 | 15,067 | - | - | Restricted Stock Units | |
| Jeffrey S. Farrow | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 13,042 | 49,746 | - | - | Common Stock | |
| Aziz Mottiwala | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 4,790 | 0 | - | - | Restricted Stock Units | |
| Aziz Mottiwala | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 26,482 | 74,536 | - | - | Common Stock | |
| Aziz Mottiwala | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 5,524 | 16,574 | - | - | Restricted Stock Units | |
| Aziz Mottiwala | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 8,020 | 16,040 | - | - | Restricted Stock Units | |
| Aziz Mottiwala | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 8,148 | 8,148 | - | - | Restricted Stock Units | |
| Bobak Azamian | Director, President/CEO and Board Chair | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 11,300 | 0 | - | - | Restricted Stock Units | |
| Bobak Azamian | Director, President/CEO and Board Chair | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 16,975 | 16,975 | - | - | Restricted Stock Units | |
| Bobak Azamian | Director, President/CEO and Board Chair | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 23,121 | 46,243 | - | - | Restricted Stock Units | |
| Bobak Azamian | Director, President/CEO and Board Chair | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 14,878 | 44,634 | - | - | Restricted Stock Units | |
| Bobak Azamian | Director, President/CEO and Board Chair | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 66,274 | 68,024 | - | - | Common Stock | |
| Seshadri Neervannan | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 5,097 | 0 | - | - | Restricted Stock Units | |
| Seshadri Neervannan | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 26,287 | 97,104 | - | - | Common Stock | |
| Seshadri Neervannan | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 5,022 | 15,067 | - | - | Restricted Stock Units | |
| Seshadri Neervannan | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 8,020 | 16,040 | - | - | Restricted Stock Units | |
| Seshadri Neervannan | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 8,148 | 8,148 | - | - | Restricted Stock Units | |
| Dianne C. Whitfield | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 7,176 | 14,351 | - | - | Restricted Stock Units | |
| Dianne C. Whitfield | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 4,463 | 0 | - | - | Restricted Stock Units | |
| Dianne C. Whitfield | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 23,909 | 47,302 | - | - | Common Stock | |
| Dianne C. Whitfield | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 5,022 | 15,067 | - | - | Restricted Stock Units | |
| Dianne C. Whitfield | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 7,248 | 7,249 | - | - | Restricted Stock Units | |
| Bryan Wahl | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 7,248 | 7,249 | - | - | Restricted Stock Units | |
| Bryan Wahl | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 7,176 | 14,351 | - | - | Restricted Stock Units | |
| Bryan Wahl | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 5,022 | 15,067 | - | - | Restricted Stock Units | |
| Bryan Wahl | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 24,236 | 76,399 | - | - | Common Stock | |
| Bryan Wahl | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 4,790 | 0 | - | - | Restricted Stock Units | |
| Elizabeth Yeu-Lin | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 2,511 | 7,534 | - | - | Restricted Stock Units | |
| Elizabeth Yeu-Lin | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2026 | 2,511 | 24,452 | - | - | Common Stock | |
| Jeffrey S. Farrow | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2026 | 30,724 | 30,724 | - | - | Stock Option (right to buy) | |
| Jeffrey S. Farrow | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2026 | 19,306 | 19,306 | - | - | Restricted Stock Units | |
| Aziz Mottiwala | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2026 | 19,306 | 19,306 | - | - | Restricted Stock Units | |
| Aziz Mottiwala | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2026 | 30,724 | 30,724 | - | - | Stock Option (right to buy) | |
| Bobak Azamian | Director, President/CEO and Board Chair | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2026 | 60,776 | 60,776 | - | - | Restricted Stock Units | |
| Bobak Azamian | Director, President/CEO and Board Chair | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2026 | 96,723 | 96,723 | - | - | Stock Option (right to buy) | |
| Seshadri Neervannan | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2026 | 27,310 | 27,310 | - | - | Stock Option (right to buy) | |
| Seshadri Neervannan | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2026 | 17,161 | 17,161 | - | - | Restricted Stock Units | |
| Dianne C. Whitfield | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2026 | 27,310 | 27,310 | - | - | Stock Option (right to buy) | |
| Dianne C. Whitfield | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2026 | 17,161 | 17,161 | - | - | Restricted Stock Units | |
| Bryan Wahl | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2026 | 27,310 | 27,310 | - | - | Stock Option (right to buy) | |
| Bryan Wahl | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2026 | 17,161 | 17,161 | - | - | Restricted Stock Units | |
| Elizabeth Yeu-Lin | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2026 | 17,161 | 17,161 | - | - | Restricted Stock Units | |
| Elizabeth Yeu-Lin | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2026 | 27,310 | 27,310 | - | - | Stock Option (right to buy) | |
| Seshadri Neervannan | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 76.67 per share. | 04 Mar 2026 | 8,366 | 70,817 | - | 76.7 | 641,421 | Common Stock |
| David E.I. Pyott | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Feb 2026 | 5,893 | 5,893 | - | - | Stock Option (right to buy) | |
| David E.I. Pyott | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Feb 2026 | 3,729 | 3,729 | - | - | Restricted Stock Units | |
| Dianne C. Whitfield | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 80.71 per share. | 02 Jan 2026 | 8,122 | 25,121 | - | 80.7 | 655,527 | Common Stock |
| Dianne C. Whitfield | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 81.90 per share. | 02 Jan 2026 | 835 | 24,286 | - | 81.9 | 68,387 | Common Stock |
| Dianne C. Whitfield | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 82.93 per share. | 02 Jan 2026 | 893 | 23,393 | - | 82.9 | 74,056 | Common Stock |
| Dianne C. Whitfield | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 80.09 per share. | 02 Jan 2026 | 5,715 | 33,243 | - | 80.1 | 457,714 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 83.54 per share. | 24 Dec 2025 | 557 | 857,991 | - | 83.5 | 46,532 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 82.41 per share. | 24 Dec 2025 | 5,443 | 858,548 | - | 82.4 | 448,558 | Common Stock |
| Seshadri Neervannan | Chief Operating Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 16 Dec 2025 | 950 | 79,183 | - | 0 | Common Stock | |
| Seshadri Neervannan | Chief Operating Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 16 Dec 2025 | 475 | 475 | - | 0 | Common Stock | |
| Dianne C. Whitfield | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 80.10 per share. | 16 Dec 2025 | 7,397 | 38,958 | - | 80.1 | 592,500 | Common Stock |
| William J. Link | Director | Sale of securities on an exchange or to another person at price $ 80.80 per share. | 15 Dec 2025 | 5,046 | 136,286 | - | 80.8 | 407,717 | Common Stock |
| William J. Link | Director | Sale of securities on an exchange or to another person at price $ 81.50 per share. | 15 Dec 2025 | 4,766 | 0 | - | 81.5 | 388,429 | Common Stock |
| William J. Link | Director | Sale of securities on an exchange or to another person at price $ 80.71 per share. | 15 Dec 2025 | 5,680 | 4,766 | - | 80.7 | 458,433 | Common Stock |
| William J. Link | Director | Sale of securities on an exchange or to another person at price $ 82.39 per share. | 15 Dec 2025 | 1,148 | 128,832 | - | 82.4 | 94,584 | Common Stock |
| William J. Link | Director | Sale of securities on an exchange or to another person at price $ 81.75 per share. | 15 Dec 2025 | 6,306 | 129,980 | - | 81.8 | 515,516 | Common Stock |
| Elizabeth Yeu-Lin | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2025 | 6,819 | 24,019 | - | - | Common Stock | |
| Elizabeth Yeu-Lin | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2025 | 6,819 | 20,459 | - | - | Restricted Stock Units | |
| Elizabeth Yeu-Lin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 79.50 per share. | 15 Dec 2025 | 2,078 | 21,941 | - | 79.5 | 165,201 | Common Stock |
| Katherine Goodrich | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2025 | 2,233 | 2,233 | - | - | Common Stock | |
| Katherine Goodrich | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2025 | 2,233 | 4,467 | - | - | Restricted Stock Units | |
| Bobak Azamian | Director, President/CEO and Board Chair | Gift of securities by or to the insider at price $ 0.00 per share. | 04 Dec 2025 | 51,885 | 1,750 | - | 0 | Common Stock | |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 55.37 per share. | 24 Sep 2025 | 6,000 | 812,106 | - | 55.4 | 332,220 | Common Stock |
| William J. Link | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 16 Sep 2025 | 2,000 | 141,332 | - | 0 | Common Stock | |
| William J. Link | Director | Sale of securities on an exchange or to another person at price $ 57.00 per share. | 08 Sep 2025 | 27,116 | 143,332 | - | 57 | 1,545,612 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 50.00 per share. | 11 Aug 2025 | 6,000 | 818,106 | - | 50 | 300,000 | Common Stock |
| Jeffrey S. Farrow | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2025 | 27,881 | 50,312 | - | - | Common Stock | |
| Jeffrey S. Farrow | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2025 | 27,881 | 55,763 | - | - | Restricted Stock Units | |
| Jeffrey S. Farrow | See Remarks | Sale of securities on an exchange or to another person at price $ 40.42 per share. | 16 Jun 2025 | 13,608 | 36,704 | - | 40.4 | 550,035 | Common Stock |
| Elizabeth Yeu-Lin | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Jun 2025 | 3,350 | 0 | - | - | Restricted Stock Units | |
| Elizabeth Yeu-Lin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 41.08 per share. | 13 Jun 2025 | 1,006 | 7,694 | - | 41.1 | 41,326 | Common Stock |
| Elizabeth Yeu-Lin | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Jun 2025 | 3,350 | 8,700 | - | - | Common Stock | |
| Wendy L. Yarno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2025 | 2,954 | 2,954 | - | - | Restricted Stock Units | |
| Wendy L. Yarno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2025 | 4,540 | 4,540 | - | - | Stock Option (right to buy) | |
| Wendy L. Yarno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2025 | 3,350 | 13,700 | - | - | Common Stock | |
| Wendy L. Yarno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2025 | 3,350 | 0 | - | - | Restricted Stock Units | |
| William J. Link | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2025 | 3,350 | 170,448 | - | - | Common Stock | |
| William J. Link | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2025 | 4,540 | 4,540 | - | - | Stock Option (right to buy) | |
| William J. Link | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2025 | 2,954 | 2,954 | - | - | Restricted Stock Units | |
| William J. Link | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2025 | 3,350 | 0 | - | - | Restricted Stock Units | |
| Bhaskar Chaudhuri | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2025 | 4,540 | 4,540 | - | - | Stock Option (right to buy) | |
| Bhaskar Chaudhuri | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2025 | 3,350 | 0 | - | - | Restricted Stock Units | |
| Bhaskar Chaudhuri | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2025 | 2,954 | 2,954 | - | - | Restricted Stock Units | |
| Bhaskar Chaudhuri | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2025 | 3,350 | 8,700 | - | - | Common Stock | |
| Andrew Goldberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2025 | 2,954 | 2,954 | - | - | Restricted Stock Units | |
| Andrew Goldberg | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2025 | 3,350 | 0 | - | - | Restricted Stock Units | |
| Andrew Goldberg | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2025 | 3,350 | 16,700 | - | - | Common Stock | |
| Andrew Goldberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2025 | 4,540 | 4,540 | - | - | Stock Option (right to buy) | |
| Katherine Goodrich | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2025 | 4,540 | 4,540 | - | - | Stock Option (right to buy) | |
| Katherine Goodrich | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2025 | 2,954 | 2,954 | - | - | Restricted Stock Units | |
| Aziz Mottiwala | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 43.76 per share. | 09 Jun 2025 | 17,500 | 47,557 | - | 43.8 | 765,800 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 50.00 per share. | 24 Mar 2025 | 6,000 | 824,106 | - | 50 | 300,000 | Common Stock |
| Jeffrey S. Farrow | See Remarks | Sale of securities on an exchange or to another person at price $ 46.29 per share. | 18 Mar 2025 | 1,284 | 24,871 | - | 46.3 | 59,436 | Common Stock |
| Jeffrey S. Farrow | See Remarks | Sale of securities on an exchange or to another person at price $ 50.11 per share. | 18 Mar 2025 | 1,186 | 22,431 | - | 50.1 | 59,430 | Common Stock |
| Jeffrey S. Farrow | See Remarks | Sale of securities on an exchange or to another person at price $ 47.40 per share. | 18 Mar 2025 | 1,254 | 23,617 | - | 47.4 | 59,440 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 50.11 per share. | 18 Mar 2025 | 3,365 | 65,057 | - | 50.1 | 168,620 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 47.40 per share. | 18 Mar 2025 | 3,557 | 68,422 | - | 47.4 | 168,602 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 46.29 per share. | 18 Mar 2025 | 3,643 | 71,979 | - | 46.3 | 168,634 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 46.29 per share. | 18 Mar 2025 | 7,131 | 70,720 | - | 46.3 | 330,094 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 47.40 per share. | 18 Mar 2025 | 8,551 | 62,169 | - | 47.4 | 405,317 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 50.11 per share. | 18 Mar 2025 | 8,534 | 53,635 | - | 50.1 | 427,639 | Common Stock |
| Seshadri Neervannan | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 46.29 per share. | 18 Mar 2025 | 2,605 | 84,660 | - | 46.3 | 120,585 | Common Stock |
| Seshadri Neervannan | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 50.11 per share. | 18 Mar 2025 | 2,435 | 79,682 | - | 50.1 | 122,018 | Common Stock |
| Seshadri Neervannan | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 47.40 per share. | 18 Mar 2025 | 2,543 | 82,117 | - | 47.4 | 120,538 | Common Stock |
| Dianne C. Whitfield | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 47.40 per share. | 18 Mar 2025 | 2,259 | 48,492 | - | 47.4 | 107,077 | Common Stock |
| Dianne C. Whitfield | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 50.11 per share. | 18 Mar 2025 | 2,137 | 46,355 | - | 50.1 | 107,085 | Common Stock |
| Dianne C. Whitfield | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 46.29 per share. | 18 Mar 2025 | 2,315 | 50,751 | - | 46.3 | 107,161 | Common Stock |
| Bryan Wahl | General Counsel | Sale of securities on an exchange or to another person at price $ 50.11 per share. | 18 Mar 2025 | 3,084 | 51,712 | - | 50.1 | 154,539 | Common Stock |
| Bryan Wahl | General Counsel | Sale of securities on an exchange or to another person at price $ 46.29 per share. | 18 Mar 2025 | 3,341 | 58,057 | - | 46.3 | 154,655 | Common Stock |
| Bryan Wahl | General Counsel | Sale of securities on an exchange or to another person at price $ 47.40 per share. | 18 Mar 2025 | 3,261 | 54,796 | - | 47.4 | 154,571 | Common Stock |
| Jeffrey S. Farrow | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 8,019 | 24,060 | - | - | Restricted Stock Units | |
| Jeffrey S. Farrow | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 8,019 | 26,155 | - | - | Common Stock | |
| Aziz Mottiwala | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 20,957 | 75,622 | - | - | Common Stock | |
| Aziz Mottiwala | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 8,019 | 24,060 | - | - | Restricted Stock Units | |
| Aziz Mottiwala | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 8,148 | 16,296 | - | - | Restricted Stock Units | |
| Aziz Mottiwala | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 4,790 | 4,790 | - | - | Restricted Stock Units | |
| Bobak Azamian | Director, President/CEO and Board Chair | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 51,395 | 77,851 | - | - | Common Stock | |
| Bobak Azamian | Director, President/CEO and Board Chair | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 23,121 | 69,364 | - | - | Restricted Stock Units | |
| Bobak Azamian | Director, President/CEO and Board Chair | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 16,975 | 33,950 | - | - | Restricted Stock Units | |
| Bobak Azamian | Director, President/CEO and Board Chair | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 11,299 | 11,300 | - | - | Restricted Stock Units | |
| Seshadri Neervannan | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 8,148 | 16,296 | - | - | Restricted Stock Units | |
| Seshadri Neervannan | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 5,097 | 5,097 | - | - | Restricted Stock Units | |
| Seshadri Neervannan | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 21,264 | 87,265 | - | - | Common Stock | |
| Seshadri Neervannan | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 8,019 | 24,060 | - | - | Restricted Stock Units | |
| Dianne C. Whitfield | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 7,175 | 21,527 | - | - | Restricted Stock Units | |
| Dianne C. Whitfield | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 18,885 | 53,066 | - | - | Common Stock | |
| Dianne C. Whitfield | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 4,462 | 4,463 | - | - | Restricted Stock Units | |
| Dianne C. Whitfield | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 7,248 | 14,497 | - | - | Restricted Stock Units | |
| Bryan Wahl | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 19,213 | 61,398 | - | - | Common Stock | |
| Bryan Wahl | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 4,790 | 4,790 | - | - | Restricted Stock Units | |
| Bryan Wahl | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 7,248 | 14,497 | - | - | Restricted Stock Units | |
| Bryan Wahl | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 7,175 | 21,527 | - | - | Restricted Stock Units | |
| Andrew Goldberg | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Mar 2025 | 7,000 | 0 | - | - | Stock Option (right to buy) | |
| Andrew Goldberg | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.89 per share. | 07 Mar 2025 | 7,000 | 13,350 | - | 12.9 | 90,230 | Common Stock |
| Jeffrey S. Farrow | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 30,628 | 30,628 | - | - | Stock Option (right to buy) | |
| Jeffrey S. Farrow | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 20,089 | 20,089 | - | - | Restricted Stock Units | |
| Aziz Mottiwala | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 22,098 | 22,098 | - | - | Restricted Stock Units | |
| Aziz Mottiwala | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 33,691 | 33,691 | - | - | Stock Option (right to buy) | |
| Bobak Azamian | Director, President/CEO and Board Chair | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 90,736 | 90,736 | - | - | Stock Option (right to buy) | |
| Bobak Azamian | Director, President/CEO and Board Chair | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 59,512 | 59,512 | - | - | Restricted Stock Units | |
| Seshadri Neervannan | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 30,628 | 30,628 | - | - | Stock Option (right to buy) | |
| Seshadri Neervannan | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 20,089 | 20,089 | - | - | Restricted Stock Units | |
| Dianne C. Whitfield | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 20,089 | 20,089 | - | - | Restricted Stock Units | |
| Dianne C. Whitfield | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 30,628 | 30,628 | - | - | Stock Option (right to buy) | |
| Bryan Wahl | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 30,628 | 30,628 | - | - | Stock Option (right to buy) | |
| Bryan Wahl | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 20,089 | 20,089 | - | - | Restricted Stock Units | |
| Elizabeth Yeu-Lin | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 15,314 | 15,314 | - | - | Stock Option (right to buy) | |
| Elizabeth Yeu-Lin | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 10,045 | 10,045 | - | - | Restricted Stock Units | |
| Katherine Goodrich | Director | 13 Nov 2024 | 6,700 | 6,700 | - | - | Restricted Stock Units | ||
| Katherine Goodrich | Director | 13 Nov 2024 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | ||
| Elizabeth Yeu-Lin | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Nov 2024 | 27,278 | 27,278 | - | - | Restricted Stock Units | |
| Elizabeth Yeu-Lin | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Nov 2024 | 41,074 | 41,074 | - | - | Stock Option (right to buy) | |
| William J. Link | Director | Other type of transaction at price $ 0.00 per share. | 12 Aug 2024 | 74,892 | 35,000 | - | 0 | Common Stock | |
| William J. Link | Director | Sale of securities on an exchange or to another person at price $ 26.53 per share. | 12 Aug 2024 | 5,021 | 0 | - | 26.5 | 133,207 | Common Stock |
| William J. Link | Director | Sale of securities on an exchange or to another person at price $ 26.01 per share. | 12 Aug 2024 | 29,979 | 5,021 | - | 26.0 | 779,754 | Common Stock |
| William J. Link | Director | Other type of transaction at price $ 0.00 per share. | 12 Aug 2024 | 27,116 | 167,098 | - | 0 | Common Stock | |
| William J. Link | Director | Other type of transaction at price $ 0.00 per share. | 12 Aug 2024 | 10,446 | 10,446 | - | 0 | Common Stock | |
| Wendy L. Yarno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2024 | 3,350 | 0 | - | - | Restricted Stock Units | |
| Wendy L. Yarno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2024 | 3,350 | 10,350 | - | - | Common Stock | |
| William J. Link | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2024 | 3,350 | 0 | - | - | Restricted Stock Units | |
| William J. Link | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2024 | 3,350 | 139,982 | - | - | Common Stock | |
| Bhaskar Chaudhuri | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2024 | 3,350 | 5,350 | - | - | Common Stock | |
| Bhaskar Chaudhuri | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2024 | 3,350 | 0 | - | - | Restricted Stock Units | |
| Rosemary A. Crane | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2024 | 3,350 | 5,350 | - | - | Common Stock | |
| Rosemary A. Crane | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2024 | 3,350 | 0 | - | - | Restricted Stock Units | |
| Andrew Goldberg | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2024 | 3,350 | 6,350 | - | - | Common Stock | |
| Andrew Goldberg | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2024 | 3,350 | 0 | - | - | Restricted Stock Units | |
| Elizabeth Yeu-Lin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2024 | 3,350 | 5,350 | - | - | Common Stock | |
| Elizabeth Yeu-Lin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2024 | 3,350 | 0 | - | - | Restricted Stock Units | |
| Jeffrey S. Farrow | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jun 2024 | 27,881 | 83,644 | - | - | Restricted Stock Units | |
| Jeffrey S. Farrow | See Remarks | Sale of securities on an exchange or to another person at price $ 27.47 per share. | 17 Jun 2024 | 10,445 | 18,136 | - | 27.5 | 286,924 | Common Stock |
| Jeffrey S. Farrow | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jun 2024 | 27,881 | 28,581 | - | - | Common Stock | |
| Wendy L. Yarno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 5,000 | 5,000 | - | - | Stock Option (right to buy) | |
| Wendy L. Yarno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 3,350 | 3,350 | - | - | Restricted Stock Units | |
| William J. Link | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 5,000 | 5,000 | - | - | Stock Option (right to buy) | |
| William J. Link | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 3,350 | 3,350 | - | - | Restricted Stock Units | |
| Bhaskar Chaudhuri | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 3,350 | 3,350 | - | - | Restricted Stock Units | |
| Bhaskar Chaudhuri | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 5,000 | 5,000 | - | - | Stock Option (right to buy) | |
| Rosemary A. Crane | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 3,350 | 3,350 | - | - | Restricted Stock Units | |
| Rosemary A. Crane | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 5,000 | 5,000 | - | - | Stock Option (right to buy) | |
| Andrew Goldberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 3,350 | 3,350 | - | - | Restricted Stock Units | |
| Andrew Goldberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 5,000 | 5,000 | - | - | Stock Option (right to buy) | |
| Elizabeth Yeu-Lin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 5,000 | 5,000 | - | - | Stock Option (right to buy) | |
| Elizabeth Yeu-Lin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 3,350 | 3,350 | - | - | Restricted Stock Units | |
| Aziz Mottiwala | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2024 | 8,148 | 24,444 | - | - | Restricted Stock Units | |
| Aziz Mottiwala | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2024 | 4,790 | 9,580 | - | - | Restricted Stock Units | |
| Aziz Mottiwala | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 30.60 per share. | 15 Mar 2024 | 4,766 | 54,075 | - | 30.6 | 145,840 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2024 | 12,938 | 58,841 | - | - | Common Stock | |
| Bobak Azamian | Director, President/CEO and Board Chair | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2024 | 28,274 | 36,871 | - | - | Common Stock | |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 30.60 per share. | 15 Mar 2024 | 10,415 | 26,456 | - | 30.6 | 318,699 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2024 | 16,975 | 50,925 | - | - | Restricted Stock Units | |
| Bobak Azamian | Director, President/CEO and Board Chair | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2024 | 11,299 | 22,599 | - | - | Restricted Stock Units | |
| Seshadri Neervannan | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2024 | 13,245 | 69,646 | - | - | Common Stock | |
| Seshadri Neervannan | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 30.60 per share. | 15 Mar 2024 | 4,879 | 64,767 | - | 30.6 | 149,297 | Common Stock |
| Seshadri Neervannan | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2024 | 5,097 | 10,194 | - | - | Restricted Stock Units | |
| Seshadri Neervannan | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2024 | 8,148 | 24,444 | - | - | Restricted Stock Units | |
| Dianne C. Whitfield | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2024 | 11,711 | 38,495 | - | - | Common Stock | |
| Dianne C. Whitfield | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 30.60 per share. | 15 Mar 2024 | 4,314 | 34,181 | - | 30.6 | 132,008 | Common Stock |
| Dianne C. Whitfield | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2024 | 4,463 | 8,925 | - | - | Restricted Stock Units | |
| Dianne C. Whitfield | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2024 | 7,248 | 21,745 | - | - | Restricted Stock Units | |
| Bryan Wahl | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2024 | 4,790 | 9,580 | - | - | Restricted Stock Units | |
| Bryan Wahl | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2024 | 12,038 | 45,387 | - | - | Common Stock | |
| Bryan Wahl | General Counsel | Sale of securities on an exchange or to another person at price $ 30.60 per share. | 15 Mar 2024 | 4,436 | 40,951 | - | 30.6 | 135,742 | Common Stock |
| Bryan Wahl | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2024 | 7,248 | 21,745 | - | - | Restricted Stock Units | |
| Jeffrey S. Farrow | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2024 | 32,079 | 32,079 | - | - | Restricted Stock Units | |
| Jeffrey S. Farrow | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2024 | 47,500 | 47,500 | - | - | Stock Option (right to buy) | |
| Aziz Mottiwala | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2024 | 32,079 | 32,079 | - | - | Restricted Stock Units | |
| Aziz Mottiwala | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2024 | 47,500 | 47,500 | - | - | Stock Option (right to buy) | |
| Bobak Azamian | Director, President/CEO and Board Chair | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2024 | 92,485 | 92,485 | - | - | Restricted Stock Units | |
| Bobak Azamian | Director, President/CEO and Board Chair | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2024 | 136,947 | 136,947 | - | - | Stock Option (right to buy) | |
| Seshadri Neervannan | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2024 | 32,079 | 32,079 | - | - | Restricted Stock Units | |
| Seshadri Neervannan | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2024 | 47,500 | 47,500 | - | - | Stock Option (right to buy) | |
| Dianne C. Whitfield | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2024 | 28,702 | 28,702 | - | - | Restricted Stock Units | |
| Dianne C. Whitfield | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2024 | 42,500 | 42,500 | - | - | Stock Option (right to buy) | |
| Bryan Wahl | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2024 | 42,500 | 42,500 | - | - | Stock Option (right to buy) | |
| Bryan Wahl | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2024 | 28,702 | 28,702 | - | - | Restricted Stock Units | |
| Elizabeth Yeu | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2024 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Azamian Bobak | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 20.22 per share. | 27 Dec 2023 | 8,000 | 830,106 | - | 20.2 | 161,760 | Common Stock |
| Azamian Bobak | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 19.96 per share. | 20 Dec 2023 | 9,443 | 868,663 | - | 20.0 | 188,482 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 20.36 per share. | 20 Dec 2023 | 30,557 | 838,106 | - | 20.4 | 622,141 | Common Stock |
| Jose M. Trevejo | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 20.00 per share. | 20 Dec 2023 | 2,252 | 2,251 | - | 20 | 45,040 | Common Stock |
| Andrew Goldberg | Director | Purchase of securities on an exchange or from another person at price $ 18.96 per share. | 15 Dec 2023 | 1,000 | 3,000 | - | 19.0 | 18,960 | Common Stock |
| Yarno L. Wendy | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Dec 2023 | 5,000 | 0 | - | - | Restricted Stock Units | |
| L. Wendy Yarno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Dec 2023 | 5,000 | 7,000 | - | - | Common Stock | |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 17.23 per share. | 23 Aug 2023 | 8,000 | 902,106 | - | 17.2 | 137,840 | Common Stock |
| Elizabeth Yeu | Director | Purchase of securities on an exchange or from another person at price $ 16.80 per share. | 15 Aug 2023 | 9,506 | 15,866 | - | 16.8 | 159,701 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 20.05 per share. | 19 Jul 2023 | 2,400 | 45,806 | - | 20.1 | 48,120 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 20.04 per share. | 19 Jul 2023 | 99,726 | 910,106 | - | 20.0 | 1,998,509 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 19.28 per share. | 19 Jul 2023 | 4,174 | 1,009,832 | - | 19.3 | 80,475 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 17.35 per share. | 12 Jul 2023 | 9,000 | 1,014,006 | - | 17.4 | 156,150 | Common Stock |
| Wendy L. Yarno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2023 | 3,350 | 3,350 | - | - | Restricted Stock Units | |
| Wendy L. Yarno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2023 | 5,000 | 5,000 | - | - | Stock Option (right to buy) | |
| William J. Link | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2023 | 3,350 | 3,350 | - | - | Restricted Stock Units | |
| William J. Link | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2023 | 5,000 | 5,000 | - | - | Stock Option (right to buy) | |
| Bhaskar Chaudhuri | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2023 | 3,350 | 3,350 | - | - | Restricted Stock Units | |
| Bhaskar Chaudhuri | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2023 | 5,000 | 5,000 | - | - | Stock Option (right to buy) | |
| Rosemary A. Crane | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2023 | 5,000 | 5,000 | - | - | Stock Option (right to buy) | |
| Rosemary A. Crane | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2023 | 3,350 | 3,350 | - | - | Restricted Stock Units | |
| Andrew Goldberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2023 | 5,000 | 5,000 | - | - | Stock Option (right to buy) | |
| Andrew Goldberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2023 | 3,350 | 3,350 | - | - | Restricted Stock Units | |
| Elizabeth Yeu | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2023 | 5,000 | 5,000 | - | - | Stock Option (right to buy) | |
| Elizabeth Yeu | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2023 | 3,350 | 3,350 | - | - | Restricted Stock Units | |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 18.63 per share. | 21 Jun 2023 | 8,000 | 1,023,006 | - | 18.6 | 149,040 | Common Stock |
| Wendy L. Yarno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2023 | 2,000 | 0 | - | - | Restricted Stock Units | |
| Wendy L. Yarno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2023 | 2,000 | 2,000 | - | - | Common Stock | |
| William J. Link | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2023 | 2,000 | 0 | - | - | Restricted Stock Units | |
| William J. Link | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2023 | 2,000 | 136,632 | - | - | Common Stock | |
| Bhaskar Chaudhuri | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2023 | 2,000 | 0 | - | - | Restricted Stock Units | |
| Bhaskar Chaudhuri | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2023 | 2,000 | 2,000 | - | - | Common Stock | |
| Rosemary A. Crane | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2023 | 2,000 | 2,000 | - | - | Common Stock | |
| Rosemary A. Crane | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2023 | 2,000 | 0 | - | - | Restricted Stock Units | |
| Andrew Goldberg | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2023 | 2,000 | 2,000 | - | - | Common Stock | |
| Andrew Goldberg | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2023 | 2,000 | 0 | - | - | Restricted Stock Units | |
| Elizabeth Yeu | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2023 | 2,000 | 2,000 | - | - | Common Stock | |
| Elizabeth Yeu | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2023 | 2,000 | 0 | - | - | Restricted Stock Units | |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 18.58 per share. | 14 Jun 2023 | 9,000 | 1,031,006 | - | 18.6 | 167,220 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 20.00 per share. | 08 Jun 2023 | 100 | 48,086 | - | 20 | 2,000 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 20.01 per share. | 08 Jun 2023 | 3,100 | 1,040,006 | - | 20.0 | 62,031 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 18.61 per share. | 06 Jun 2023 | 2,143 | 50,686 | - | 18.6 | 39,881 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 19.34 per share. | 06 Jun 2023 | 2,500 | 48,186 | - | 19.3 | 48,350 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 15.90 per share. | 17 May 2023 | 8,000 | 1,043,106 | - | 15.9 | 127,200 | Common Stock |
| William J. Link | Director | Other type of transaction at price $ 0.00 per share. | 11 May 2023 | 41,219 | 109,892 | - | 0 | Common Stock | |
| William J. Link | Director | Other type of transaction at price $ 0.00 per share. | 11 May 2023 | 215,576 | 0 | - | 0 | Common Stock | |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 16.80 per share. | 10 May 2023 | 9,000 | 1,051,106 | - | 16.8 | 151,200 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 15.10 per share. | 28 Apr 2023 | 5,841 | 1,060,106 | - | 15.1 | 88,199 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 15.13 per share. | 28 Apr 2023 | 4,278 | 1,065,947 | - | 15.1 | 64,726 | Common Stock |
| Jeffrey S. Farrow | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2023 | 111,525 | 111,525 | - | - | Restricted Stock Units | |
| Jeffrey S. Farrow | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2023 | 163,397 | 163,397 | - | - | Stock Option (right to buy) | |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 15.03 per share. | 21 Apr 2023 | 2,311 | 1,070,225 | - | 15.0 | 34,734 | Common Stock |
| Leonard M. Greenstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 14.02 per share. | 20 Apr 2023 | 5,000 | 26,785 | - | 14.0 | 70,100 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 13.60 per share. | 19 Apr 2023 | 8,000 | 1,072,536 | - | 13.6 | 108,800 | Common Stock |
| Leonard M. Greenstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 12.89 per share. | 21 Mar 2023 | 326 | 32,463 | - | 12.9 | 4,202 | Common Stock |
| Leonard M. Greenstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 12.15 per share. | 21 Mar 2023 | 346 | 31,785 | - | 12.2 | 4,204 | Common Stock |
| Leonard M. Greenstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 12.64 per share. | 21 Mar 2023 | 332 | 32,131 | - | 12.6 | 4,196 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 12.89 per share. | 21 Mar 2023 | 349 | 53,558 | - | 12.9 | 4,499 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 12.64 per share. | 21 Mar 2023 | 357 | 53,201 | - | 12.6 | 4,512 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 12.15 per share. | 21 Mar 2023 | 372 | 52,829 | - | 12.2 | 4,520 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 12.15 per share. | 21 Mar 2023 | 737 | 8,597 | - | 12.2 | 8,955 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 12.89 per share. | 21 Mar 2023 | 679 | 10,043 | - | 12.9 | 8,752 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 12.64 per share. | 21 Mar 2023 | 709 | 9,334 | - | 12.6 | 8,962 | Common Stock |
| Seshadri Neervannan | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 12.89 per share. | 21 Mar 2023 | 372 | 55,465 | - | 12.9 | 4,795 | Common Stock |
| Seshadri Neervannan | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 12.64 per share. | 21 Mar 2023 | 379 | 55,086 | - | 12.6 | 4,791 | Common Stock |
| Seshadri Neervannan | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 12.15 per share. | 21 Mar 2023 | 390 | 54,696 | - | 12.2 | 4,739 | Common Stock |
| Dianne C. Whitfield | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 12.15 per share. | 21 Mar 2023 | 345 | 11,219 | - | 12.2 | 4,192 | Common Stock |
| Dianne C. Whitfield | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 12.89 per share. | 21 Mar 2023 | 326 | 11,897 | - | 12.9 | 4,202 | Common Stock |
| Dianne C. Whitfield | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 12.64 per share. | 21 Mar 2023 | 333 | 11,564 | - | 12.6 | 4,209 | Common Stock |
| Bryan Wahl | General Counsel | Sale of securities on an exchange or to another person at price $ 12.15 per share. | 21 Mar 2023 | 371 | 16,402 | - | 12.2 | 4,508 | Common Stock |
| Bryan Wahl | General Counsel | Sale of securities on an exchange or to another person at price $ 12.89 per share. | 21 Mar 2023 | 350 | 17,130 | - | 12.9 | 4,512 | Common Stock |
| Bryan Wahl | General Counsel | Sale of securities on an exchange or to another person at price $ 12.64 per share. | 21 Mar 2023 | 357 | 16,773 | - | 12.6 | 4,512 | Common Stock |
| Jose M. Trevejo | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 12.89 per share. | 21 Mar 2023 | 519 | 7,101 | - | 12.9 | 6,690 | Common Stock |
| Jose M. Trevejo | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 12.15 per share. | 21 Mar 2023 | 465 | 6,107 | - | 12.2 | 5,650 | Common Stock |
| Jose M. Trevejo | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 12.64 per share. | 21 Mar 2023 | 529 | 6,572 | - | 12.6 | 6,687 | Common Stock |
| Leonard M. Greenstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 12.61 per share. | 17 Mar 2023 | 333 | 32,789 | - | 12.6 | 4,199 | Common Stock |
| Leonard M. Greenstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 13.28 per share. | 17 Mar 2023 | 316 | 33,122 | - | 13.3 | 4,196 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 12.61 per share. | 17 Mar 2023 | 358 | 53,907 | - | 12.6 | 4,514 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 13.28 per share. | 17 Mar 2023 | 339 | 54,265 | - | 13.3 | 4,502 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 12.61 per share. | 17 Mar 2023 | 741 | 10,722 | - | 12.6 | 9,344 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 13.28 per share. | 17 Mar 2023 | 795 | 11,463 | - | 13.3 | 10,558 | Common Stock |
| Seshadri Neervannan | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 13.28 per share. | 17 Mar 2023 | 360 | 56,217 | - | 13.3 | 4,781 | Common Stock |
| Seshadri Neervannan | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 12.61 per share. | 17 Mar 2023 | 380 | 55,837 | - | 12.6 | 4,792 | Common Stock |
| Mark Holdbrook | V.P., Clinical Affairs | Sale of securities on an exchange or to another person at price $ 12.61 per share. | 17 Mar 2023 | 198 | 3,191 | - | 12.6 | 2,497 | Common Stock |
| Mark Holdbrook | V.P., Clinical Affairs | Sale of securities on an exchange or to another person at price $ 13.28 per share. | 17 Mar 2023 | 188 | 3,389 | - | 13.3 | 2,497 | Common Stock |
| Dianne C. Whitfield | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 12.61 per share. | 17 Mar 2023 | 333 | 12,223 | - | 12.6 | 4,199 | Common Stock |
| Dianne C. Whitfield | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 13.28 per share. | 17 Mar 2023 | 316 | 12,556 | - | 13.3 | 4,196 | Common Stock |
| Bryan Wahl | General Counsel | Sale of securities on an exchange or to another person at price $ 13.28 per share. | 17 Mar 2023 | 339 | 17,837 | - | 13.3 | 4,502 | Common Stock |
| Bryan Wahl | General Counsel | Sale of securities on an exchange or to another person at price $ 12.61 per share. | 17 Mar 2023 | 357 | 17,480 | - | 12.6 | 4,502 | Common Stock |
| Jose M. Trevejo | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 13.28 per share. | 17 Mar 2023 | 504 | 8,150 | - | 13.3 | 6,693 | Common Stock |
| Jose M. Trevejo | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 12.61 per share. | 17 Mar 2023 | 530 | 7,620 | - | 12.6 | 6,683 | Common Stock |
| William J. Link | Director | Other type of transaction at price $ 0.00 per share. | 15 Mar 2023 | 215,575 | 215,576 | - | 0 | Common Stock | |
| William J. Link | Director | Other type of transaction at price $ 0.00 per share. | 15 Mar 2023 | 52,194 | 68,673 | - | 0 | Common Stock | |
| Leonard M. Greenstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 4,462 | 38,751 | - | - | Common Stock | |
| Leonard M. Greenstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 4,462 | 13,388 | - | - | Restricted Stock Units | |
| Leonard M. Greenstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 13.44 per share. | 15 Mar 2023 | 5,000 | 33,438 | - | 13.4 | 67,200 | Common Stock |
| Leonard M. Greenstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 13.43 per share. | 15 Mar 2023 | 313 | 38,438 | - | 13.4 | 4,204 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 13.43 per share. | 15 Mar 2023 | 336 | 54,604 | - | 13.4 | 4,512 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 4,790 | 54,940 | - | - | Common Stock | |
| Aziz Mottiwala | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 4,790 | 14,370 | - | - | Restricted Stock Units | |
| Bobak Azamian | Director, President/CEO and Board Chair | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 11,299 | 13,049 | - | - | Common Stock | |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 13.79 per share. | 15 Mar 2023 | 8,000 | 1,080,536 | - | 13.8 | 110,320 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 11,299 | 33,898 | - | - | Restricted Stock Units | |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 13.43 per share. | 15 Mar 2023 | 791 | 12,258 | - | 13.4 | 10,623 | Common Stock |
| Seshadri Neervannan | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 5,097 | 15,291 | - | - | Restricted Stock Units | |
| Seshadri Neervannan | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 13.43 per share. | 15 Mar 2023 | 357 | 56,577 | - | 13.4 | 4,795 | Common Stock |
| Seshadri Neervannan | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 5,097 | 56,934 | - | - | Common Stock | |
| Mark Holdbrook | V.P., Clinical Affairs | Sale of securities on an exchange or to another person at price $ 13.43 per share. | 15 Mar 2023 | 187 | 3,577 | - | 13.4 | 2,511 | Common Stock |
| Mark Holdbrook | V.P., Clinical Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 2,653 | 7,959 | - | - | Restricted Stock Units | |
| Mark Holdbrook | V.P., Clinical Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 2,653 | 3,764 | - | - | Common Stock | |
| Dianne C. Whitfield | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 13.43 per share. | 15 Mar 2023 | 313 | 12,872 | - | 13.4 | 4,204 | Common Stock |
| Dianne C. Whitfield | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 4,462 | 13,388 | - | - | Restricted Stock Units | |
| Dianne C. Whitfield | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 4,462 | 13,185 | - | - | Common Stock | |
| Bryan Wahl | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 4,790 | 14,370 | - | - | Restricted Stock Units | |
| Bryan Wahl | General Counsel | Sale of securities on an exchange or to another person at price $ 13.43 per share. | 15 Mar 2023 | 337 | 18,176 | - | 13.4 | 4,526 | Common Stock |
| Bryan Wahl | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 4,790 | 18,513 | - | - | Common Stock | |
| Jose M. Trevejo | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 7,549 | 22,648 | - | - | Restricted Stock Units | |
| Jose M. Trevejo | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 13.43 per share. | 15 Mar 2023 | 499 | 8,654 | - | 13.4 | 6,702 | Common Stock |
| Jose M. Trevejo | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 7,549 | 9,153 | - | - | Common Stock | |
| Leonard M. Greenstein | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Mar 2023 | 40,097 | 40,097 | - | - | Stock Option (right to buy) | |
| Leonard M. Greenstein | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Mar 2023 | 27,160 | 27,160 | - | - | Restricted Stock Units | |
| Aziz Mottiwala | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Mar 2023 | 32,592 | 32,592 | - | - | Restricted Stock Units | |
| Aziz Mottiwala | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Mar 2023 | 48,116 | 48,116 | - | - | Stock Option (right to buy) | |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 15.02 per share. | 08 Mar 2023 | 4,853 | 1,089,253 | - | 15.0 | 72,892 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 15.01 per share. | 08 Mar 2023 | 717 | 1,088,536 | - | 15.0 | 10,762 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Mar 2023 | 67,900 | 67,900 | - | - | Restricted Stock Units | |
| Bobak Azamian | Director, President/CEO and Board Chair | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Mar 2023 | 100,242 | 100,242 | - | - | Stock Option (right to buy) | |
| Seshadri Neervannan | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Mar 2023 | 32,592 | 32,592 | - | - | Restricted Stock Units | |
| Seshadri Neervannan | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Mar 2023 | 48,116 | 48,116 | - | - | Stock Option (right to buy) | |
| Dianne C. Whitfield | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Mar 2023 | 42,802 | 42,802 | - | - | Stock Option (right to buy) | |
| Dianne C. Whitfield | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Mar 2023 | 28,993 | 28,993 | - | - | Restricted Stock Units | |
| Bryan Wahl | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Mar 2023 | 42,802 | 42,802 | - | - | Stock Option (right to buy) | |
| Bryan Wahl | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Mar 2023 | 28,993 | 28,993 | - | - | Restricted Stock Units | |
| Jose M. Trevejo | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Mar 2023 | 45,459 | 45,459 | - | - | Stock Option (right to buy) | |
| Jose M. Trevejo | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Mar 2023 | 30,792 | 30,792 | - | - | Restricted Stock Units | |
| Leonard M. Greenstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 15.12 per share. | 16 Feb 2023 | 5,000 | 34,289 | - | 15.1 | 75,600 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 15.28 per share. | 15 Feb 2023 | 8,000 | 1,094,106 | - | 15.3 | 122,240 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 15.14 per share. | 08 Feb 2023 | 9,000 | 1,102,106 | - | 15.1 | 136,260 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 15.45 per share. | 23 Jan 2023 | 4,856 | 1,111,106 | - | 15.4 | 75,025 | Common Stock |
| Leonard M. Greenstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 14.56 per share. | 19 Jan 2023 | 5,000 | 39,289 | - | 14.6 | 72,800 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 15.00 per share. | 18 Jan 2023 | 240 | 1,116,373 | - | 15 | 3,600 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 14.56 per share. | 18 Jan 2023 | 8,000 | 1,116,613 | - | 14.6 | 116,480 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 15.11 per share. | 11 Jan 2023 | 3,904 | 1,124,613 | - | 15.1 | 58,989 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 15.17 per share. | 09 Jan 2023 | 905 | 1,128,517 | - | 15.2 | 13,729 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 15.15 per share. | 09 Jan 2023 | 729 | 1,129,422 | - | 15.1 | 11,044 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 15.00 per share. | 06 Jan 2023 | 411 | 1,129,740 | - | 15 | 6,165 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 14.57 per share. | 21 Dec 2022 | 8,000 | 1,130,151 | - | 14.6 | 116,560 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 15.01 per share. | 16 Dec 2022 | 535 | 1,138,151 | - | 15.0 | 8,030 | Common Stock |
| Leonard M. Greenstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 14.64 per share. | 15 Dec 2022 | 5,000 | 44,289 | - | 14.6 | 73,200 | Common Stock |
| Bobak Azamian | Director, President/CEO and Board Chair | Sale of securities on an exchange or to another person at price $ 15.08 per share. | 14 Dec 2022 | 6,420 | 1,138,686 | - | 15.1 | 96,814 | Common Stock |
| Wendy L. Yarno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Dec 2022 | 5,000 | 5,000 | - | - | Restricted Stock Units | |
| Dianne C. Whitfield | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 16.90 per share. | 02 Dec 2022 | 1,154 | 8,723 | - | 16.9 | 19,503 | Common Stock |
| Bryan Wahl | General Counsel | Sale of securities on an exchange or to another person at price $ 16.90 per share. | 02 Dec 2022 | 1,154 | 13,723 | - | 16.9 | 19,503 | Common Stock |
| Dianne C. Whitfield | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Nov 2022 | 10,251 | 12,224 | - | 0 | Common Stock | |
| Dianne C. Whitfield | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Nov 2022 | 10,251 | 23,920 | - | - | Restricted Stock Units | |
| Dianne C. Whitfield | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 16.75 per share. | 29 Nov 2022 | 1,165 | 9,877 | - | 16.8 | 19,514 | Common Stock |
| Dianne C. Whitfield | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 16.50 per share. | 29 Nov 2022 | 1,182 | 11,042 | - | 16.5 | 19,503 | Common Stock |
| Bryan Wahl | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Nov 2022 | 10,251 | 17,224 | - | 0 | Common Stock | |
| Bryan Wahl | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Nov 2022 | 10,251 | 23,920 | - | - | Restricted Stock Units | |
| Bryan Wahl | General Counsel | Sale of securities on an exchange or to another person at price $ 16.75 per share. | 29 Nov 2022 | 1,164 | 14,877 | - | 16.8 | 19,497 | Common Stock |
| Bryan Wahl | General Counsel | Sale of securities on an exchange or to another person at price $ 16.50 per share. | 29 Nov 2022 | 1,183 | 16,041 | - | 16.5 | 19,520 | Common Stock |
| Leonard M. Greenstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 16.54 per share. | 17 Nov 2022 | 5,000 | 49,289 | - | 16.5 | 82,700 | Common Stock |
| Bobak Azamian | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 16.81 per share. | 16 Nov 2022 | 7,255 | 1,145,851 | - | 16.8 | 121,957 | Common Stock |
| Bobak Azamian | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 17.31 per share. | 16 Nov 2022 | 745 | 1,145,106 | - | 17.3 | 12,896 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 17.72 per share. | 15 Nov 2022 | 6,857 | 49,729 | - | 17.7 | 121,506 | Common Stock |
| William J. Link | Director | Other type of transaction at price $ 0.00 per share. | 10 Nov 2022 | 215,575 | 431,151 | - | 0 | Common Stock | |
| William J. Link | Director | Other type of transaction at price $ 0.00 per share. | 10 Nov 2022 | 8,382 | 16,479 | - | 0 | Common Stock | |
| Bobak Azamian | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 17.87 per share. | 09 Nov 2022 | 9,000 | 1,153,106 | - | 17.9 | 160,830 | Common Stock |
| Leonard M. Greenstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 16.62 per share. | 20 Oct 2022 | 123 | 54,289 | - | 16.6 | 2,044 | Common Stock |
| Leonard M. Greenstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 15.90 per share. | 20 Oct 2022 | 4,877 | 54,412 | - | 15.9 | 77,544 | Common Stock |
| Bobak Azamian | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 17.60 per share. | 19 Oct 2022 | 100 | 1,162,106 | - | 17.6 | 1,760 | Common Stock |
| Bobak Azamian | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 16.91 per share. | 19 Oct 2022 | 7,900 | 1,162,206 | - | 16.9 | 133,589 | Common Stock |
| Bobak Azamian | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 16.24 per share. | 12 Oct 2022 | 2,821 | 1,170,106 | - | 16.2 | 45,813 | Common Stock |
| Bobak Azamian | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 15.76 per share. | 12 Oct 2022 | 6,179 | 1,172,927 | - | 15.8 | 97,381 | Common Stock |
| Bobak Azamian | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 17.05 per share. | 21 Sep 2022 | 100 | 1,179,106 | - | 17.1 | 1,705 | Common Stock |
| Bobak Azamian | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 16.30 per share. | 21 Sep 2022 | 7,900 | 1,179,206 | - | 16.3 | 128,770 | Common Stock |
| Leonard M. Greenstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 16.03 per share. | 15 Sep 2022 | 5,000 | 59,289 | - | 16.0 | 80,150 | Common Stock |
| Bobak Azamian | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 16.01 per share. | 14 Sep 2022 | 9,000 | 1,187,106 | - | 16.0 | 144,090 | Common Stock |
| Elizabeth Yeu-Lin | Director | Purchase of securities on an exchange or from another person at price $ 16.29 per share. | 14 Sep 2022 | 6,360 | 6,360 | - | 16.3 | 103,604 | Common Stock |
| Elizabeth Yeu-Lin | Director | Purchase of securities on an exchange or from another person at price $ 16.03 per share. | 14 Sep 2022 | 12,040 | 12,040 | - | 16.0 | 193,001 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Aug 2022 | 4,416 | 10,573 | - | - | Employee Stock Option (right to buy) | |
| Aziz Mottiwala | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.99 per share. | 24 Aug 2022 | 4,416 | 55,814 | - | 11.0 | 48,532 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.45 per share. | 24 Aug 2022 | 772 | 56,586 | - | 0.4 | 347 | Common Stock |
| Aziz Mottiwala | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Aug 2022 | 772 | 0 | - | - | Employee Stock Option (right to buy) | |
| Leonard M. Greenstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 16.30 per share. | 18 Aug 2022 | 5,000 | 64,289 | - | 16.3 | 81,500 | Common Stock |
| Bobak Azamian | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 17.44 per share. | 17 Aug 2022 | 736 | 1,196,106 | - | 17.4 | 12,836 | Common Stock |
| Bobak Azamian | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 16.50 per share. | 17 Aug 2022 | 7,264 | 1,196,842 | - | 16.5 | 119,856 | Common Stock |
| William J. Link | Director | Other type of transaction at price $ 0.00 per share. | 15 Aug 2022 | 3,749 | 8,097 | - | 0 | Common Stock | |
| William J. Link | Director | Other type of transaction at price $ 0.00 per share. | 15 Aug 2022 | 215,575 | 646,726 | - | 0 | Common Stock | |
| Wendy L. Yarno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 7,000 | 7,000 | - | - | Stock Option (right to buy) | |
| Wendy L. Yarno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 2,000 | 2,000 | - | - | Restricted Stock Units | |
| William J. Link | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 2,000 | 2,000 | - | - | Restricted Stock Units | |
| William J. Link | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 7,000 | 7,000 | - | - | Stock Option (right to buy) | |
| Bhaskar Chaudhuri | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 2,000 | 2,000 | - | - | Restricted Stock Units | |
| Bhaskar Chaudhuri | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 7,000 | 7,000 | - | - | Stock Option (right to buy) | |
| Rosemary A. Crane | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 7,000 | 7,000 | - | - | Stock Option (right to buy) | |
| Rosemary A. Crane | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 2,000 | 2,000 | - | - | Restricted Stock Units | |
| Michael Ackermann | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 12,000 | 12,000 | - | - | Restricted Stock Units | |
| Michael Ackermann | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 7,000 | 7,000 | - | - | Stock Option (right to buy) | |
| Andrew Goldberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 2,000 | 2,000 | - | - | Restricted Stock Units | |
| Andrew Goldberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 7,000 | 7,000 | - | - | Stock Option (right to buy) | |
| Elizabeth Yeu-Lin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 7,000 | 7,000 | - | - | Employee Stock Option (right to buy) | |
| Elizabeth Yeu-Lin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 2,000 | 2,000 | - | - | Restricted Stock Units | |
| Michael Ackermann | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jun 2022 | 4,257 | 0 | - | - | Restricted Stock Units | |
| Michael Ackermann | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jun 2022 | 4,257 | 1,208,273 | - | - | Common Stock | |
| Michael Ackermann | Director | Purchase of securities on an exchange or from another person at price $ 13.50 per share. | 05 May 2022 | 100,000 | 100,000 | - | 13.5 | 1,350,000 | Common Stock |
| Leonard M. Greenstein | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2022 | 60,846 | 60,846 | - | - | Stock Option (right to buy) | |
| Leonard M. Greenstein | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2022 | 17,850 | 17,850 | - | - | Restricted Stock Units | |
| Aziz Mottiwala | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2022 | 19,160 | 19,160 | - | - | Restricted Stock Units | |
| Aziz Mottiwala | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2022 | 65,312 | 65,312 | - | - | Stock Option (right to buy) | |
| Bobak Azamian | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2022 | 154,067 | 154,067 | - | - | Stock Option (right to buy) | |
| Bobak Azamian | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2022 | 45,197 | 45,197 | - | - | Restricted Stock Units | |
| Seshadri Neervannan | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2022 | 20,388 | 20,388 | - | - | Restricted Stock Units | |
| Seshadri Neervannan | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2022 | 69,498 | 69,498 | - | - | Stock Option (right to buy) |