XNAS 07 Nov, 2025 4:30 PM (EST)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| James C. Edgemond | CFO AND TREASURER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Nov 2025 | 21,000 | 31,312 | - | - | Stock Options | |
| James C. Edgemond | CFO AND TREASURER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 146.03 per share. | 04 Nov 2025 | 21,000 | 29,118 (0%) | 0% | 146.0 | 3,066,630 | Common Stock |
| James C. Edgemond | CFO AND TREASURER | Sale of securities on an exchange or to another person at price $ 432.86 per share. | 04 Nov 2025 | 1,074 | 27,946 (0%) | 0% | 432.9 | 464,892 | Common Stock |
| James C. Edgemond | CFO AND TREASURER | Sale of securities on an exchange or to another person at price $ 433.78 per share. | 04 Nov 2025 | 1,512 | 26,434 (0%) | 0% | 433.8 | 655,872 | Common Stock |
| James C. Edgemond | CFO AND TREASURER | Sale of securities on an exchange or to another person at price $ 434.96 per share. | 04 Nov 2025 | 1,679 | 24,755 (0%) | 0% | 435.0 | 730,302 | Common Stock |
| James C. Edgemond | CFO AND TREASURER | Sale of securities on an exchange or to another person at price $ 432.09 per share. | 04 Nov 2025 | 98 | 29,020 (0%) | 0% | 432.1 | 42,345 | Common Stock |
| James C. Edgemond | CFO AND TREASURER | Sale of securities on an exchange or to another person at price $ 435.81 per share. | 04 Nov 2025 | 6,088 | 18,667 (0%) | 0% | 435.8 | 2,653,239 | Common Stock |
| James C. Edgemond | CFO AND TREASURER | Sale of securities on an exchange or to another person at price $ 436.78 per share. | 04 Nov 2025 | 7,317 | 11,350 (0%) | 0% | 436.8 | 3,195,910 | Common Stock |
| James C. Edgemond | CFO AND TREASURER | Sale of securities on an exchange or to another person at price $ 437.74 per share. | 04 Nov 2025 | 2,752 | 8,598 (0%) | 0% | 437.7 | 1,204,662 | Common Stock |
| James C. Edgemond | CFO AND TREASURER | Sale of securities on an exchange or to another person at price $ 438.50 per share. | 04 Nov 2025 | 360 | 8,238 (0%) | 0% | 438.5 | 157,859 | Common Stock |
| James C. Edgemond | CFO AND TREASURER | Sale of securities on an exchange or to another person at price $ 439.51 per share. | 04 Nov 2025 | 120 | 8,118 (0%) | 0% | 439.5 | 52,741 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 04 Nov 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Nov 2025 | 4,000 | 126,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 442.26 per share. | 04 Nov 2025 | 1,000 | 130 (0%) | 0% | 442.3 | 442,262 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 440.67 per share. | 04 Nov 2025 | 500 | 1,130 (0%) | 0% | 440.7 | 220,336 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 438.76 per share. | 04 Nov 2025 | 1,000 | 1,630 (0%) | 0% | 438.8 | 438,762 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Nov 2025 | 4,000 | 122,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 434.30 per share. | 04 Nov 2025 | 1,000 | 2,630 (0%) | 0% | 434.3 | 434,297 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 432.53 per share. | 04 Nov 2025 | 500 | 3,630 (0%) | 0% | 432.5 | 216,265 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 04 Nov 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 435.07 per share. | 04 Nov 2025 | 1,200 | 130 (0%) | 0% | 435.1 | 522,079 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 433.93 per share. | 04 Nov 2025 | 2,300 | 1,330 (0%) | 0% | 433.9 | 998,047 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 432.75 per share. | 04 Nov 2025 | 500 | 3,630 (0%) | 0% | 432.8 | 216,375 | Common Stock |
| Christopher Causey | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 03 Nov 2025 | 450 | 4,190 (0%) | 0% | 0 | Common Stock | |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 436.45 per share. | 03 Nov 2025 | 2,121 | 2,731 (0%) | 0% | 436.4 | 925,707 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 437.70 per share. | 03 Nov 2025 | 890 | 1,841 (0%) | 0% | 437.7 | 389,551 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 438.34 per share. | 03 Nov 2025 | 585 | 1,256 (0%) | 0% | 438.3 | 256,427 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 439.35 per share. | 03 Nov 2025 | 575 | 681 (0%) | 0% | 439.4 | 252,627 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 440.71 per share. | 03 Nov 2025 | 511 | 170 (0%) | 0% | 440.7 | 225,204 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 441.95 per share. | 03 Nov 2025 | 170 | 0 (0%) | 0% | 441.9 | 75,131 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 146.03 per share. | 03 Nov 2025 | 7,875 | 7,875 (0%) | 0% | 146.0 | 1,149,986 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 434.68 per share. | 03 Nov 2025 | 2,918 | 8,056 (0%) | 0% | 434.7 | 1,268,407 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 433.52 per share. | 03 Nov 2025 | 2,687 | 10,974 (0%) | 0% | 433.5 | 1,164,868 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 432.55 per share. | 03 Nov 2025 | 964 | 13,661 (0%) | 0% | 432.5 | 416,976 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 03 Nov 2025 | 14,625 | 14,625 (0%) | 0% | 135.4 | 1,980,518 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 435.52 per share. | 03 Nov 2025 | 3,204 | 4,852 (0%) | 0% | 435.5 | 1,395,391 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Nov 2025 | 7,875 | 10,500 | - | - | Stock Options | |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Nov 2025 | 14,625 | 41,250 | - | - | Stock Options | |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 417.50 per share. | 03 Nov 2025 | 7,875 | 0 (0%) | 0% | 417.5 | 3,287,785 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 447.83 per share. | 31 Oct 2025 | 1,000 | 3,130 (0%) | 0% | 447.8 | 447,826 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 434.33 per share. | 31 Oct 2025 | 360 | 2,630 (0%) | 0% | 434.3 | 156,359 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 433.78 per share. | 31 Oct 2025 | 1,140 | 2,990 (0%) | 0% | 433.8 | 494,506 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 31 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 451.49 per share. | 31 Oct 2025 | 2,463 | 130 (0%) | 0% | 451.5 | 1,112,011 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 449.83 per share. | 31 Oct 2025 | 537 | 2,593 (0%) | 0% | 449.8 | 241,561 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 31 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Oct 2025 | 4,000 | 130,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Oct 2025 | 4,000 | 134,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 443.01 per share. | 31 Oct 2025 | 1,000 | 130 (0%) | 0% | 443.0 | 443,010 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 441.39 per share. | 31 Oct 2025 | 500 | 1,130 (0%) | 0% | 441.4 | 220,695 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 438.62 per share. | 31 Oct 2025 | 1,000 | 1,630 (0%) | 0% | 438.6 | 438,624 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 30 Oct 2025 | 11,000 | 47,781 (0%) | 0% | 135.4 | 1,489,620 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2025 | 11,000 | 22,000 | - | - | Stock Option | |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 454.15 per share. | 30 Oct 2025 | 393 | 36,781 (0%) | 0% | 454.1 | 178,480 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 452.33 per share. | 30 Oct 2025 | 1,285 | 37,174 (0%) | 0% | 452.3 | 581,243 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 451.57 per share. | 30 Oct 2025 | 1,849 | 38,459 (0%) | 0% | 451.6 | 834,952 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 450.64 per share. | 30 Oct 2025 | 2,247 | 40,308 (0%) | 0% | 450.6 | 1,012,579 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 449.46 per share. | 30 Oct 2025 | 3,441 | 42,555 (0%) | 0% | 449.5 | 1,546,606 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 448.56 per share. | 30 Oct 2025 | 1,143 | 45,996 (0%) | 0% | 448.6 | 512,706 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 447.34 per share. | 30 Oct 2025 | 642 | 47,139 (0%) | 0% | 447.3 | 287,195 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 450.23 per share. | 29 Oct 2025 | 1,459 | 630 (0%) | 0% | 450.2 | 656,891 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 448.43 per share. | 29 Oct 2025 | 541 | 2,089 (0%) | 0% | 448.4 | 242,598 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 447.14 per share. | 29 Oct 2025 | 1,500 | 2,630 (0%) | 0% | 447.1 | 670,703 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 29 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 439.99 per share. | 29 Oct 2025 | 900 | 130 (0%) | 0% | 440.0 | 395,991 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 435.24 per share. | 29 Oct 2025 | 2,000 | 1,030 (0%) | 0% | 435.2 | 870,480 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 433.31 per share. | 29 Oct 2025 | 1,100 | 3,030 (0%) | 0% | 433.3 | 476,641 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 29 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Oct 2025 | 4,000 | 138,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Oct 2025 | 4,000 | 142,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 451.29 per share. | 29 Oct 2025 | 500 | 130 (0%) | 0% | 451.3 | 225,645 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 146.03 per share. | 27 Oct 2025 | 1,750 | 7,875 (0%) | 0% | 146.0 | 255,553 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 417.50 per share. | 27 Oct 2025 | 7,875 | 130 (0%) | 0% | 417.5 | 3,287,785 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Oct 2025 | 14,625 | 55,875 | - | - | Stock Options | |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Oct 2025 | 6,125 | 18,375 | - | - | Stock Options | |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Oct 2025 | 1,750 | 0 | - | - | Stock Options | |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 27 Oct 2025 | 14,625 | 14,625 (0%) | 0% | 135.4 | 1,980,518 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 417.50 per share. | 27 Oct 2025 | 14,625 | 0 (0%) | 0% | 417.5 | 6,105,886 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 146.03 per share. | 27 Oct 2025 | 6,125 | 6,125 (0%) | 0% | 146.0 | 894,434 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Oct 2025 | 4,000 | 150,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Oct 2025 | 4,000 | 146,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 413.58 per share. | 27 Oct 2025 | 1,991 | 2,139 (0%) | 0% | 413.6 | 823,437 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 27 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 27 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 420.29 per share. | 27 Oct 2025 | 1,186 | 130 (0%) | 0% | 420.3 | 498,462 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 415.02 per share. | 27 Oct 2025 | 509 | 1,630 (0%) | 0% | 415.0 | 211,245 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 414.42 per share. | 27 Oct 2025 | 1,814 | 1,316 (0%) | 0% | 414.4 | 751,756 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 411.96 per share. | 27 Oct 2025 | 1,000 | 3,130 (0%) | 0% | 412.0 | 411,955 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 417.92 per share. | 27 Oct 2025 | 1,500 | 130 (0%) | 0% | 417.9 | 626,873 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Oct 2025 | 4,000 | 158,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Oct 2025 | 4,000 | 154,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 426.40 per share. | 23 Oct 2025 | 500 | 130 (0%) | 0% | 426.4 | 213,200 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 424.64 per share. | 23 Oct 2025 | 563 | 630 (0%) | 0% | 424.6 | 239,070 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 423.56 per share. | 23 Oct 2025 | 2,937 | 1,193 (0%) | 0% | 423.6 | 1,243,990 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 23 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 424.16 per share. | 23 Oct 2025 | 500 | 130 (0%) | 0% | 424.2 | 212,080 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 422.58 per share. | 23 Oct 2025 | 1,000 | 630 (0%) | 0% | 422.6 | 422,575 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 421.63 per share. | 23 Oct 2025 | 2,500 | 1,630 (0%) | 0% | 421.6 | 1,054,075 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 23 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Oct 2025 | 4,000 | 166,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 422.15 per share. | 21 Oct 2025 | 2,200 | 1,296 (0%) | 0% | 422.2 | 928,731 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 423.07 per share. | 21 Oct 2025 | 1,166 | 130 (0%) | 0% | 423.1 | 493,298 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 21 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 425.38 per share. | 21 Oct 2025 | 1,088 | 3,042 (0%) | 0% | 425.4 | 462,817 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 426.18 per share. | 21 Oct 2025 | 1,412 | 1,630 (0%) | 0% | 426.2 | 601,772 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 430.35 per share. | 21 Oct 2025 | 1,000 | 630 (0%) | 0% | 430.4 | 430,354 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 432.20 per share. | 21 Oct 2025 | 500 | 130 (0%) | 0% | 432.2 | 216,100 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 21 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 420.47 per share. | 21 Oct 2025 | 634 | 3,496 (0%) | 0% | 420.5 | 266,578 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Oct 2025 | 4,000 | 162,000 | - | - | Stock Option | |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Oct 2025 | 14,625 | 70,500 | - | - | Stock Options | |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 427.41 per share. | 20 Oct 2025 | 7,875 | 0 (0%) | 0% | 427.4 | 3,365,846 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 146.03 per share. | 20 Oct 2025 | 7,875 | 7,875 (0%) | 0% | 146.0 | 1,149,986 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 427.41 per share. | 20 Oct 2025 | 14,625 | 0 (0%) | 0% | 427.4 | 6,250,857 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 20 Oct 2025 | 14,625 | 14,625 (0%) | 0% | 135.4 | 1,980,518 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Oct 2025 | 7,875 | 1,750 | - | - | Stock Options | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 17 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Oct 2025 | 4,000 | 170,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Oct 2025 | 4,000 | 174,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 434.22 per share. | 17 Oct 2025 | 500 | 130 (0%) | 0% | 434.2 | 217,110 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 427.56 per share. | 17 Oct 2025 | 400 | 630 (0%) | 0% | 427.6 | 171,022 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 424.68 per share. | 17 Oct 2025 | 1,301 | 1,030 (0%) | 0% | 424.7 | 552,512 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 422.30 per share. | 17 Oct 2025 | 200 | 2,331 (0%) | 0% | 422.3 | 84,460 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 421.04 per share. | 17 Oct 2025 | 1,599 | 2,531 (0%) | 0% | 421.0 | 673,246 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 17 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 432.31 per share. | 17 Oct 2025 | 1,100 | 130 (0%) | 0% | 432.3 | 475,537 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 430.05 per share. | 17 Oct 2025 | 2,900 | 1,230 (0%) | 0% | 430.1 | 1,247,150 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 432.59 per share. | 16 Oct 2025 | 2,078 | 39,232 (0%) | 0% | 432.6 | 898,920 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 431.72 per share. | 16 Oct 2025 | 2,516 | 41,310 (0%) | 0% | 431.7 | 1,086,199 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 430.59 per share. | 16 Oct 2025 | 955 | 43,826 (0%) | 0% | 430.6 | 411,212 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 429.61 per share. | 16 Oct 2025 | 1,092 | 44,781 (0%) | 0% | 429.6 | 469,136 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 428.51 per share. | 16 Oct 2025 | 1,908 | 45,873 (0%) | 0% | 428.5 | 817,595 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 16 Oct 2025 | 11,000 | 47,781 (0%) | 0% | 135.4 | 1,489,620 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Oct 2025 | 11,000 | 33,000 | - | - | Stock Option | |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 435.00 per share. | 16 Oct 2025 | 1 | 36,781 (0%) | 0% | 435 | 435 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 434.76 per share. | 16 Oct 2025 | 798 | 36,782 (0%) | 0% | 434.8 | 346,937 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 433.45 per share. | 16 Oct 2025 | 1,652 | 37,580 (0%) | 0% | 433.5 | 716,061 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 15 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 432.86 per share. | 15 Oct 2025 | 846 | 130 (0%) | 0% | 432.9 | 366,200 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2025 | 4,000 | 182,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2025 | 4,000 | 178,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 431.51 per share. | 15 Oct 2025 | 1,654 | 976 (0%) | 0% | 431.5 | 713,715 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 430.23 per share. | 15 Oct 2025 | 1,500 | 2,630 (0%) | 0% | 430.2 | 645,338 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 15 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 436.47 per share. | 15 Oct 2025 | 2,000 | 130 (0%) | 0% | 436.5 | 872,944 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 434.80 per share. | 15 Oct 2025 | 1,000 | 2,130 (0%) | 0% | 434.8 | 434,800 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 433.42 per share. | 15 Oct 2025 | 1,000 | 3,130 (0%) | 0% | 433.4 | 433,420 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 437.53 per share. | 13 Oct 2025 | 1,000 | 3,130 (0%) | 0% | 437.5 | 437,530 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 441.26 per share. | 13 Oct 2025 | 2,000 | 130 (0%) | 0% | 441.3 | 882,520 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 434.01 per share. | 13 Oct 2025 | 1,478 | 2,130 (0%) | 0% | 434.0 | 641,463 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 432.74 per share. | 13 Oct 2025 | 522 | 3,608 (0%) | 0% | 432.7 | 225,890 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 13 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 441.40 per share. | 13 Oct 2025 | 3,000 | 130 (0%) | 0% | 441.4 | 1,324,200 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 13 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Oct 2025 | 4,000 | 186,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Oct 2025 | 4,000 | 190,000 | - | - | Stock Option | |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Oct 2025 | 14,625 | 85,125 | - | - | Stock Options | |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Oct 2025 | 7,875 | 9,625 | - | - | Stock Options | |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 440.35 per share. | 13 Oct 2025 | 7,875 | 0 (0%) | 0% | 440.4 | 3,467,787 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 146.03 per share. | 13 Oct 2025 | 7,875 | 7,875 (0%) | 0% | 146.0 | 1,149,986 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 440.35 per share. | 13 Oct 2025 | 14,625 | 0 (0%) | 0% | 440.4 | 6,440,176 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 13 Oct 2025 | 14,625 | 14,625 (0%) | 0% | 135.4 | 1,980,518 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 445.25 per share. | 09 Oct 2025 | 1,000 | 3,130 (0%) | 0% | 445.3 | 445,250 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 09 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 449.58 per share. | 09 Oct 2025 | 2,000 | 1,130 (0%) | 0% | 449.6 | 899,165 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 451.24 per share. | 09 Oct 2025 | 1,000 | 130 (0%) | 0% | 451.2 | 451,240 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 09 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 442.96 per share. | 09 Oct 2025 | 1,000 | 3,130 (0%) | 0% | 443.0 | 442,958 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 445.28 per share. | 09 Oct 2025 | 3,000 | 130 (0%) | 0% | 445.3 | 1,335,830 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Oct 2025 | 4,000 | 194,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Oct 2025 | 4,000 | 198,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 07 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Oct 2025 | 4,000 | 202,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Oct 2025 | 4,000 | 206,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 456.52 per share. | 07 Oct 2025 | 1,000 | 130 (0%) | 0% | 456.5 | 456,520 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 454.14 per share. | 07 Oct 2025 | 900 | 1,130 (0%) | 0% | 454.1 | 408,726 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 448.89 per share. | 07 Oct 2025 | 860 | 2,030 (0%) | 0% | 448.9 | 386,045 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 445.29 per share. | 07 Oct 2025 | 1,240 | 2,890 (0%) | 0% | 445.3 | 552,158 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 07 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 453.28 per share. | 07 Oct 2025 | 1,000 | 130 (0%) | 0% | 453.3 | 453,280 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 451.86 per share. | 07 Oct 2025 | 2,000 | 1,130 (0%) | 0% | 451.9 | 903,730 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 450.31 per share. | 07 Oct 2025 | 1,000 | 3,130 (0%) | 0% | 450.3 | 450,310 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 449.82 per share. | 06 Oct 2025 | 400 | 14,225 (0%) | 0% | 449.8 | 179,928 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 450.97 per share. | 06 Oct 2025 | 800 | 13,425 (0%) | 0% | 451.0 | 360,777 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 452.03 per share. | 06 Oct 2025 | 11,975 | 1,450 (0%) | 0% | 452.0 | 5,413,011 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 453.16 per share. | 06 Oct 2025 | 1,250 | 200 (0%) | 0% | 453.2 | 566,449 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 253.98 per share. | 06 Oct 2025 | 200 | 0 (0%) | 0% | 254.0 | 50,795 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 146.03 per share. | 06 Oct 2025 | 7,875 | 7,875 (0%) | 0% | 146.0 | 1,149,986 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 450.06 per share. | 06 Oct 2025 | 300 | 7,575 (0%) | 0% | 450.1 | 135,017 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 451.01 per share. | 06 Oct 2025 | 500 | 7,075 (0%) | 0% | 451.0 | 225,507 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 452.04 per share. | 06 Oct 2025 | 6,625 | 450 (0%) | 0% | 452.0 | 2,994,745 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 453.51 per share. | 06 Oct 2025 | 350 | 100 (0%) | 0% | 453.5 | 158,728 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 454.81 per share. | 06 Oct 2025 | 100 | 0 (0%) | 0% | 454.8 | 45,481 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Oct 2025 | 7,875 | 17,500 | - | - | Stock Options | |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Oct 2025 | 14,625 | 99,750 | - | - | Stock Options | |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 06 Oct 2025 | 14,625 | 14,625 (0%) | 0% | 135.4 | 1,980,518 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 445.24 per share. | 03 Oct 2025 | 1,000 | 3,130 (0%) | 0% | 445.2 | 445,240 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 451.18 per share. | 03 Oct 2025 | 3,000 | 130 (0%) | 0% | 451.2 | 1,353,525 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Oct 2025 | 4,000 | 210,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Oct 2025 | 4,000 | 214,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 03 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 443.63 per share. | 03 Oct 2025 | 1,000 | 3,130 (0%) | 0% | 443.6 | 443,630 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 445.61 per share. | 03 Oct 2025 | 1,629 | 1,501 (0%) | 0% | 445.6 | 725,902 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 448.81 per share. | 03 Oct 2025 | 1,371 | 130 (0%) | 0% | 448.8 | 615,315 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 03 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Mahon Paul A. | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 433.72 per share. | 02 Oct 2025 | 1,430 | 46,351 (0%) | 0% | 433.7 | 620,224 | Common Stock |
| A. Paul Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 435.22 per share. | 02 Oct 2025 | 1,828 | 44,523 (0%) | 0% | 435.2 | 795,574 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Oct 2025 | 11,000 | 44,000 | - | - | Stock Option | |
| Mahon Paul A. | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 436.24 per share. | 02 Oct 2025 | 1,881 | 42,642 (0%) | 0% | 436.2 | 820,566 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 439.19 per share. | 02 Oct 2025 | 346 | 37,255 (0%) | 0% | 439.2 | 151,959 | Common Stock |
| Paul Mahon A. | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 437.15 per share. | 02 Oct 2025 | 3,136 | 39,506 (0%) | 0% | 437.2 | 1,370,905 | Common Stock |
| A. Paul Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 02 Oct 2025 | 11,000 | 47,781 (0%) | 0% | 135.4 | 1,489,620 | Common Stock |
| A. Paul Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 438.17 per share. | 02 Oct 2025 | 1,905 | 37,601 (0%) | 0% | 438.2 | 834,710 | Common Stock |
| Mahon A. Paul | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 440.16 per share. | 02 Oct 2025 | 474 | 36,781 (0%) | 0% | 440.2 | 208,636 | Common Stock |
| Martine Rothblatt A. | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 423.32 per share. | 01 Oct 2025 | 1,080 | 3,050 (0%) | 0% | 423.3 | 457,188 | Common Stock |
| Rothblatt Martine A. | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 436.70 per share. | 01 Oct 2025 | 2,000 | 130 (0%) | 0% | 436.7 | 873,400 | Common Stock |
| A. Rothblatt Martine | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 433.06 per share. | 01 Oct 2025 | 2,000 | 2,130 (0%) | 0% | 433.1 | 866,125 | Common Stock |
| Martine Rothblatt A. | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 01 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Rothblatt A. Martine | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 01 Oct 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2025 | 4,000 | 218,000 | - | - | Stock Option | |
| A. Rothblatt Martine | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2025 | 4,000 | 222,000 | - | - | Stock Option | |
| A. Rothblatt Martine | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 426.78 per share. | 01 Oct 2025 | 844 | 130 (0%) | 0% | 426.8 | 360,200 | Common Stock |
| A. Martine Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 426.02 per share. | 01 Oct 2025 | 2,076 | 974 (0%) | 0% | 426.0 | 884,408 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 29 Sep 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Sep 2025 | 4,000 | 226,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Sep 2025 | 4,000 | 230,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 422.84 per share. | 29 Sep 2025 | 4,000 | 130 (0%) | 0% | 422.8 | 1,691,358 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 29 Sep 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 430.81 per share. | 29 Sep 2025 | 1,600 | 130 (0%) | 0% | 430.8 | 689,300 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 423.78 per share. | 29 Sep 2025 | 1,784 | 1,730 (0%) | 0% | 423.8 | 756,017 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 418.12 per share. | 29 Sep 2025 | 415 | 3,514 (0%) | 0% | 418.1 | 173,518 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 416.38 per share. | 29 Sep 2025 | 201 | 3,929 (0%) | 0% | 416.4 | 83,692 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 417.52 per share. | 29 Sep 2025 | 665 | 6,860 (0%) | 0% | 417.5 | 277,650 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 416.60 per share. | 29 Sep 2025 | 350 | 7,525 (0%) | 0% | 416.6 | 145,809 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 146.03 per share. | 29 Sep 2025 | 7,875 | 7,875 (0%) | 0% | 146.0 | 1,149,986 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 430.75 per share. | 29 Sep 2025 | 65 | 0 (0%) | 0% | 430.8 | 27,999 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 429.50 per share. | 29 Sep 2025 | 96 | 65 (0%) | 0% | 429.5 | 41,232 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 428.64 per share. | 29 Sep 2025 | 489 | 161 (0%) | 0% | 428.6 | 209,603 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 425.84 per share. | 29 Sep 2025 | 490 | 650 (0%) | 0% | 425.8 | 208,662 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 424.80 per share. | 29 Sep 2025 | 674 | 1,140 (0%) | 0% | 424.8 | 286,316 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 423.93 per share. | 29 Sep 2025 | 2,206 | 1,814 (0%) | 0% | 423.9 | 935,187 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 422.72 per share. | 29 Sep 2025 | 2,073 | 4,020 (0%) | 0% | 422.7 | 876,292 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 421.75 per share. | 29 Sep 2025 | 2,659 | 6,093 (0%) | 0% | 421.8 | 1,121,434 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 420.94 per share. | 29 Sep 2025 | 1,971 | 8,752 (0%) | 0% | 420.9 | 829,680 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 419.77 per share. | 29 Sep 2025 | 1,327 | 10,723 (0%) | 0% | 419.8 | 557,036 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 418.80 per share. | 29 Sep 2025 | 690 | 12,050 (0%) | 0% | 418.8 | 288,970 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 417.52 per share. | 29 Sep 2025 | 1,235 | 12,740 (0%) | 0% | 417.5 | 515,635 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 416.60 per share. | 29 Sep 2025 | 650 | 13,975 (0%) | 0% | 416.6 | 270,787 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 29 Sep 2025 | 14,625 | 14,625 (0%) | 0% | 135.4 | 1,980,518 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 418.80 per share. | 29 Sep 2025 | 371 | 6,489 (0%) | 0% | 418.8 | 155,374 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Sep 2025 | 7,875 | 25,375 | - | - | Stock Options | |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Sep 2025 | 14,625 | 114,375 | - | - | Stock Options | |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 430.74 per share. | 29 Sep 2025 | 35 | 0 (0%) | 0% | 430.7 | 15,076 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 429.51 per share. | 29 Sep 2025 | 51 | 35 (0%) | 0% | 429.5 | 21,905 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 428.64 per share. | 29 Sep 2025 | 264 | 96 (0%) | 0% | 428.6 | 113,160 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 425.84 per share. | 29 Sep 2025 | 264 | 360 (0%) | 0% | 425.8 | 112,422 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 424.80 per share. | 29 Sep 2025 | 363 | 614 (0%) | 0% | 424.8 | 154,203 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 423.93 per share. | 29 Sep 2025 | 1,187 | 977 (0%) | 0% | 423.9 | 503,203 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 422.72 per share. | 29 Sep 2025 | 1,116 | 2,164 (0%) | 0% | 422.7 | 471,752 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 421.75 per share. | 29 Sep 2025 | 1,432 | 3,280 (0%) | 0% | 421.8 | 603,947 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 420.94 per share. | 29 Sep 2025 | 1,062 | 4,712 (0%) | 0% | 420.9 | 447,043 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 419.77 per share. | 29 Sep 2025 | 715 | 5,774 (0%) | 0% | 419.8 | 300,136 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Sep 2025 | 4,000 | 238,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Sep 2025 | 4,000 | 234,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 428.68 per share. | 25 Sep 2025 | 3,000 | 130 (0%) | 0% | 428.7 | 1,286,031 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 426.86 per share. | 25 Sep 2025 | 1,000 | 3,130 (0%) | 0% | 426.9 | 426,860 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 25 Sep 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 431.90 per share. | 25 Sep 2025 | 2,300 | 130 (0%) | 0% | 431.9 | 993,376 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 430.25 per share. | 25 Sep 2025 | 800 | 2,430 (0%) | 0% | 430.3 | 344,202 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 429.07 per share. | 25 Sep 2025 | 900 | 3,230 (0%) | 0% | 429.1 | 386,161 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 25 Sep 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Christopher Causey | Director | Sale of securities on an exchange or to another person at price $ 440.00 per share. | 24 Sep 2025 | 1,000 | 4,865 (0%) | 0% | 440 | 440,000 | Common Stock |
| Christopher Causey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Sep 2025 | 1,000 | 9,320 | - | - | Stock Option | |
| Christopher Causey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 119.76 per share. | 24 Sep 2025 | 1,000 | 5,865 (0%) | 0% | 119.8 | 119,760 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Sep 2025 | 4,000 | 242,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 435.84 per share. | 23 Sep 2025 | 684 | 130 (0%) | 0% | 435.8 | 298,115 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 433.77 per share. | 23 Sep 2025 | 3,316 | 814 (0%) | 0% | 433.8 | 1,438,374 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 23 Sep 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 419.79 per share. | 23 Sep 2025 | 2,000 | 130 (0%) | 0% | 419.8 | 839,573 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 416.51 per share. | 23 Sep 2025 | 2,000 | 2,130 (0%) | 0% | 416.5 | 833,020 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 23 Sep 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Sep 2025 | 4,000 | 246,000 | - | - | Stock Option | |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 146.03 per share. | 22 Sep 2025 | 7,875 | 7,875 (0%) | 0% | 146.0 | 1,149,986 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 416.35 per share. | 22 Sep 2025 | 14,625 | 0 (0%) | 0% | 416.4 | 6,089,170 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 22 Sep 2025 | 14,625 | 14,625 (0%) | 0% | 135.4 | 1,980,518 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Sep 2025 | 7,875 | 33,250 | - | - | Stock Options | |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Sep 2025 | 14,625 | 129,000 | - | - | Stock Options | |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 416.35 per share. | 22 Sep 2025 | 7,875 | 0 (0%) | 0% | 416.4 | 3,278,784 | Common Stock |
| Judy D. Olian | Director | Sale of securities on an exchange or to another person at price $ 415.43 per share. | 19 Sep 2025 | 1,800 | 5,045 (0%) | 0% | 415.4 | 747,768 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 19 Sep 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 417.89 per share. | 19 Sep 2025 | 2,000 | 130 (0%) | 0% | 417.9 | 835,775 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 416.72 per share. | 19 Sep 2025 | 2,000 | 2,130 (0%) | 0% | 416.7 | 833,438 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Sep 2025 | 4,000 | 254,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Sep 2025 | 4,000 | 250,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 19 Sep 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 411.08 per share. | 19 Sep 2025 | 4,000 | 130 (0%) | 0% | 411.1 | 1,644,310 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 406.39 per share. | 18 Sep 2025 | 3,222 | 40,086 (0%) | 0% | 406.4 | 1,309,394 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 405.45 per share. | 18 Sep 2025 | 2,973 | 43,308 (0%) | 0% | 405.5 | 1,205,403 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 402.50 per share. | 18 Sep 2025 | 400 | 47,381 (0%) | 0% | 402.5 | 161,000 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 407.42 per share. | 18 Sep 2025 | 2,105 | 37,981 (0%) | 0% | 407.4 | 857,613 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 408.11 per share. | 18 Sep 2025 | 1,200 | 36,781 (0%) | 0% | 408.1 | 489,737 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Sep 2025 | 11,000 | 55,000 | - | - | Stock Option | |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 18 Sep 2025 | 11,000 | 47,781 (0%) | 0% | 135.4 | 1,489,620 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 404.33 per share. | 18 Sep 2025 | 1,100 | 46,281 (0%) | 0% | 404.3 | 444,760 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 406.04 per share. | 17 Sep 2025 | 879 | 130 (0%) | 0% | 406.0 | 356,905 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 405.20 per share. | 17 Sep 2025 | 1,121 | 1,009 (0%) | 0% | 405.2 | 454,225 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 403.27 per share. | 17 Sep 2025 | 2,000 | 2,130 (0%) | 0% | 403.3 | 806,535 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 17 Sep 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 400.90 per share. | 17 Sep 2025 | 865 | 130 (0%) | 0% | 400.9 | 346,780 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 17 Sep 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 399.97 per share. | 17 Sep 2025 | 3,135 | 995 (0%) | 0% | 400.0 | 1,253,907 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Sep 2025 | 4,000 | 258,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Sep 2025 | 4,000 | 262,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Sep 2025 | 4,000 | 266,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 16 Sep 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 400.59 per share. | 16 Sep 2025 | 3,000 | 130 (0%) | 0% | 400.6 | 1,201,781 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 399.28 per share. | 16 Sep 2025 | 1,000 | 3,130 (0%) | 0% | 399.3 | 399,281 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 397.96 per share. | 15 Sep 2025 | 820 | 6,950 (0%) | 0% | 398.0 | 326,325 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 396.87 per share. | 15 Sep 2025 | 105 | 7,770 (0%) | 0% | 396.9 | 41,671 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 146.03 per share. | 15 Sep 2025 | 7,875 | 7,875 (0%) | 0% | 146.0 | 1,149,986 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 403.00 per share. | 15 Sep 2025 | 2,052 | 0 (0%) | 0% | 403.0 | 826,965 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 402.06 per share. | 15 Sep 2025 | 1,470 | 2,052 (0%) | 0% | 402.1 | 591,035 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 400.79 per share. | 15 Sep 2025 | 5,103 | 3,522 (0%) | 0% | 400.8 | 2,045,227 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 400.09 per share. | 15 Sep 2025 | 2,910 | 8,625 (0%) | 0% | 400.1 | 1,164,254 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 399.07 per share. | 15 Sep 2025 | 1,415 | 11,535 (0%) | 0% | 399.1 | 564,689 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 398.02 per share. | 15 Sep 2025 | 1,380 | 12,950 (0%) | 0% | 398.0 | 549,268 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 15 Sep 2025 | 14,625 | 14,625 (0%) | 0% | 135.4 | 1,980,518 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 396.95 per share. | 15 Sep 2025 | 295 | 14,330 (0%) | 0% | 397.0 | 117,101 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Sep 2025 | 7,875 | 41,125 | - | - | StockOptions | |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Sep 2025 | 14,625 | 143,625 | - | - | StockOptions | |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 403.08 per share. | 15 Sep 2025 | 1,005 | 0 (0%) | 0% | 403.1 | 405,091 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 402.12 per share. | 15 Sep 2025 | 668 | 1,005 (0%) | 0% | 402.1 | 268,618 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 400.86 per share. | 15 Sep 2025 | 2,068 | 1,673 (0%) | 0% | 400.9 | 828,975 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 400.24 per share. | 15 Sep 2025 | 2,289 | 3,741 (0%) | 0% | 400.2 | 916,148 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 399.19 per share. | 15 Sep 2025 | 920 | 6,030 (0%) | 0% | 399.2 | 367,259 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 402.21 per share. | 12 Sep 2025 | 1,000 | 3,130 (0%) | 0% | 402.2 | 402,210 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Sep 2025 | 4,000 | 270,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Sep 2025 | 4,000 | 274,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 398.19 per share. | 12 Sep 2025 | 1,460 | 130 (0%) | 0% | 398.2 | 581,356 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 397.71 per share. | 12 Sep 2025 | 2,540 | 1,590 (0%) | 0% | 397.7 | 1,010,180 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 12 Sep 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 404.89 per share. | 12 Sep 2025 | 2,000 | 130 (0%) | 0% | 404.9 | 809,780 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 403.91 per share. | 12 Sep 2025 | 1,000 | 2,130 (0%) | 0% | 403.9 | 403,910 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 12 Sep 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Tommy G. Thompson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 229.81 per share. | 10 Sep 2025 | 4,560 | 13,040 (0%) | 0% | 229.8 | 1,047,934 | Common Stock |
| Tommy G. Thompson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2025 | 4,560 | 0 | - | - | Stock Option | |
| Tommy G. Thompson | Director | Sale of securities on an exchange or to another person at price $ 403.36 per share. | 10 Sep 2025 | 4,560 | 8,480 (0%) | 0% | 403.4 | 1,839,322 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 399.33 per share. | 10 Sep 2025 | 2,000 | 130 (0%) | 0% | 399.3 | 798,653 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 398.11 per share. | 10 Sep 2025 | 2,000 | 2,130 (0%) | 0% | 398.1 | 796,220 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 10 Sep 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 397.23 per share. | 10 Sep 2025 | 4,000 | 130 (0%) | 0% | 397.2 | 1,588,904 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 10 Sep 2025 | 4,000 | 4,130 (0%) | 0% | 120.3 | 481,040 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2025 | 4,000 | 282,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2025 | 4,000 | 278,000 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 399.43 per share. | 09 Sep 2025 | 1,835 | 130 (0%) | 0% | 399.4 | 732,947 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 398.28 per share. | 09 Sep 2025 | 6,165 | 1,965 (0%) | 0% | 398.3 | 2,455,427 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 120.26 per share. | 09 Sep 2025 | 8,000 | 8,130 (0%) | 0% | 120.3 | 962,080 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Sep 2025 | 8,000 | 286,000 | - | - | Stock Option | |
| Jan Malcolm | Director | Sale of securities on an exchange or to another person at price $ 400.29 per share. | 09 Sep 2025 | 700 | 520 (0%) | 0% | 400.3 | 280,203 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 400.08 per share. | 08 Sep 2025 | 6,500 | 0 (0%) | 0% | 400.1 | 2,600,528 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 393.86 per share. | 08 Sep 2025 | 4,875 | 6,500 (0%) | 0% | 393.9 | 1,920,045 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 397.41 per share. | 08 Sep 2025 | 11,375 | 11,375 (0%) | 0% | 397.4 | 4,520,573 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 396.10 per share. | 08 Sep 2025 | 100 | 0 (0%) | 0% | 396.1 | 39,610 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 394.33 per share. | 08 Sep 2025 | 350 | 100 (0%) | 0% | 394.3 | 138,014 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 392.50 per share. | 08 Sep 2025 | 400 | 450 (0%) | 0% | 392.5 | 157,002 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 391.42 per share. | 08 Sep 2025 | 400 | 850 (0%) | 0% | 391.4 | 156,566 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 390.46 per share. | 08 Sep 2025 | 500 | 1,250 (0%) | 0% | 390.5 | 195,230 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 146.03 per share. | 08 Sep 2025 | 1,750 | 1,750 (0%) | 0% | 146.0 | 255,553 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 396.22 per share. | 08 Sep 2025 | 200 | 0 (0%) | 0% | 396.2 | 79,245 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 395.03 per share. | 08 Sep 2025 | 233 | 200 (0%) | 0% | 395.0 | 92,043 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 394.08 per share. | 08 Sep 2025 | 300 | 433 (0%) | 0% | 394.1 | 118,224 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 392.18 per share. | 08 Sep 2025 | 1,100 | 733 (0%) | 0% | 392.2 | 431,396 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 391.16 per share. | 08 Sep 2025 | 1,000 | 1,833 (0%) | 0% | 391.2 | 391,156 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 389.82 per share. | 08 Sep 2025 | 417 | 2,833 (0%) | 0% | 389.8 | 162,553 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 08 Sep 2025 | 3,250 | 3,250 (0%) | 0% | 135.4 | 440,115 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Sep 2025 | 6,125 | 49,000 | - | - | Stock Options | |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Sep 2025 | 11,375 | 158,250 | - | - | Stock Options | |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Sep 2025 | 3,250 | 169,625 | - | - | Stock Options | |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Sep 2025 | 1,750 | 24,500 | - | - | Stock Options | |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 387.86 per share. | 04 Sep 2025 | 850 | 39,279 (0%) | 0% | 387.9 | 329,683 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 387.41 per share. | 04 Sep 2025 | 1,128 | 40,129 (0%) | 0% | 387.4 | 436,996 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 386.51 per share. | 04 Sep 2025 | 1,499 | 41,257 (0%) | 0% | 386.5 | 579,380 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 384.90 per share. | 04 Sep 2025 | 275 | 42,756 (0%) | 0% | 384.9 | 105,848 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 383.28 per share. | 04 Sep 2025 | 300 | 43,031 (0%) | 0% | 383.3 | 114,983 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 382.21 per share. | 04 Sep 2025 | 350 | 43,331 (0%) | 0% | 382.2 | 133,773 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 381.58 per share. | 04 Sep 2025 | 2,335 | 43,681 (0%) | 0% | 381.6 | 890,997 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 380.62 per share. | 04 Sep 2025 | 1,266 | 46,016 (0%) | 0% | 380.6 | 481,867 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 379.47 per share. | 04 Sep 2025 | 499 | 47,282 (0%) | 0% | 379.5 | 189,357 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 04 Sep 2025 | 11,000 | 47,781 (0%) | 0% | 135.4 | 1,489,620 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 389.16 per share. | 04 Sep 2025 | 1,800 | 37,479 (0%) | 0% | 389.2 | 700,485 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 390.46 per share. | 04 Sep 2025 | 400 | 37,079 (0%) | 0% | 390.5 | 156,185 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 392.03 per share. | 04 Sep 2025 | 98 | 36,981 (0%) | 0% | 392.0 | 38,419 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 396.54 per share. | 04 Sep 2025 | 200 | 36,781 (0%) | 0% | 396.5 | 79,308 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Sep 2025 | 11,000 | 66,000 | - | - | Stock Option | |
| Christopher Causey | Director | Sale of securities on an exchange or to another person at price $ 430.00 per share. | 02 Sep 2025 | 1,000 | 5,865 (0%) | 0% | 430 | 430,000 | Common Stock |
| Christopher Causey | Director | Sale of securities on an exchange or to another person at price $ 419.63 per share. | 02 Sep 2025 | 1,000 | 6,865 (0%) | 0% | 419.6 | 419,630 | Common Stock |
| Christopher Causey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 132.30 per share. | 02 Sep 2025 | 3,000 | 7,865 (0%) | 0% | 132.3 | 396,900 | Common Stock |
| Christopher Causey | Director | Sale of securities on an exchange or to another person at price $ 420.00 per share. | 02 Sep 2025 | 1,000 | 4,865 (0%) | 0% | 420 | 420,000 | Common Stock |
| Christopher Causey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 3,000 | 0 | - | - | Stock Option | |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 419.61 per share. | 02 Sep 2025 | 95 | 6,125 (0%) | 0% | 419.6 | 39,863 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 417.45 per share. | 02 Sep 2025 | 367 | 6,220 (0%) | 0% | 417.4 | 153,204 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 410.35 per share. | 02 Sep 2025 | 100 | 6,587 (0%) | 0% | 410.4 | 41,035 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 408.28 per share. | 02 Sep 2025 | 300 | 6,687 (0%) | 0% | 408.3 | 122,483 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 407.26 per share. | 02 Sep 2025 | 888 | 6,987 (0%) | 0% | 407.3 | 361,651 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 146.03 per share. | 02 Sep 2025 | 7,875 | 7,875 (0%) | 0% | 146.0 | 1,149,986 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 419.35 per share. | 02 Sep 2025 | 72 | 0 (0%) | 0% | 419.3 | 30,193 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 416.30 per share. | 02 Sep 2025 | 200 | 400 (0%) | 0% | 416.3 | 83,261 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 413.38 per share. | 02 Sep 2025 | 32 | 600 (0%) | 0% | 413.4 | 13,228 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 412.70 per share. | 02 Sep 2025 | 168 | 632 (0%) | 0% | 412.7 | 69,333 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 409.97 per share. | 02 Sep 2025 | 1,144 | 800 (0%) | 0% | 410.0 | 469,005 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 408.97 per share. | 02 Sep 2025 | 700 | 1,944 (0%) | 0% | 409.0 | 286,280 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 407.34 per share. | 02 Sep 2025 | 500 | 2,644 (0%) | 0% | 407.3 | 203,669 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 405.59 per share. | 02 Sep 2025 | 106 | 3,144 (0%) | 0% | 405.6 | 42,993 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 419.63 per share. | 02 Sep 2025 | 11,375 | 3,250 (0%) | 0% | 419.6 | 4,773,291 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 02 Sep 2025 | 14,625 | 14,625 (0%) | 0% | 135.4 | 1,980,518 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 418.03 per share. | 02 Sep 2025 | 328 | 72 (0%) | 0% | 418.0 | 137,114 | Common Stock |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 7,875 | 55,125 | - | - | Stock Options | |
| Michael Benkowitz | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 14,625 | 172,875 | - | - | Stock Options | |
| Michael Benkowitz | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 419.63 per share. | 02 Sep 2025 | 6,125 | 0 (0%) | 0% | 419.6 | 2,570,234 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 309.43 per share. | 21 Aug 2025 | 4,234 | 38,876 (0%) | 0% | 309.4 | 1,310,122 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 310.25 per share. | 21 Aug 2025 | 2,095 | 36,781 (0%) | 0% | 310.2 | 649,971 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Aug 2025 | 11,000 | 77,000 | - | - | Stock Option | |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 21 Aug 2025 | 11,000 | 47,781 (0%) | 0% | 135.4 | 1,489,620 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 304.56 per share. | 21 Aug 2025 | 600 | 47,181 (0%) | 0% | 304.6 | 182,739 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 306.12 per share. | 21 Aug 2025 | 300 | 46,881 (0%) | 0% | 306.1 | 91,837 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 307.39 per share. | 21 Aug 2025 | 1,441 | 45,440 (0%) | 0% | 307.4 | 442,943 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 308.43 per share. | 21 Aug 2025 | 2,330 | 43,110 (0%) | 0% | 308.4 | 718,637 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 299.48 per share. | 07 Aug 2025 | 2,918 | 42,119 (0%) | 0% | 299.5 | 873,889 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 300.47 per share. | 07 Aug 2025 | 2,837 | 39,282 (0%) | 0% | 300.5 | 852,424 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 301.67 per share. | 07 Aug 2025 | 1,401 | 37,881 (0%) | 0% | 301.7 | 422,634 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 302.70 per share. | 07 Aug 2025 | 1,000 | 36,881 (0%) | 0% | 302.7 | 302,697 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 297.49 per share. | 07 Aug 2025 | 1,391 | 46,390 (0%) | 0% | 297.5 | 413,812 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 07 Aug 2025 | 11,000 | 47,781 (0%) | 0% | 135.4 | 1,489,620 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Aug 2025 | 11,000 | 88,000 | - | - | Stock Option | |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 303.45 per share. | 07 Aug 2025 | 100 | 36,781 (0%) | 0% | 303.5 | 30,345 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 298.73 per share. | 07 Aug 2025 | 1,353 | 45,037 (0%) | 0% | 298.7 | 404,179 | Common Stock |
| Christopher Patusky | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jul 2025 | 590 | 1,490 (0%) | 0% | 0 | Common Stock | |
| Christopher Patusky | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2025 | 1,830 | 1,830 | - | - | Stock Options | |
| Christopher Patusky | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2025 | 650 | 650 | - | - | Restricted Stock Unit | |
| Christopher Patusky | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jul 2025 | 590 | 0 | - | - | Restricted Stock Unit | |
| Louis W. Sullivan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jul 2025 | 590 | 0 | - | - | Restricted Stock Unit | |
| Louis W. Sullivan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2025 | 1,830 | 1,830 | - | - | Stock Options | |
| Louis W. Sullivan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2025 | 650 | 650 | - | - | Restricted Stock Unit | |
| Louis W. Sullivan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jul 2025 | 590 | 590 (0%) | 0% | 0 | Common Stock | |
| Raymond Dwek | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2025 | 3,650 | 3,650 | - | - | Stock Options | |
| Raymond C. Kurzweil | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2025 | 1,830 | 1,830 | - | - | Stock Options | |
| Raymond C. Kurzweil | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2025 | 650 | 650 | - | - | Restricted Stock Unit | |
| Raymond C. Kurzweil | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jul 2025 | 590 | 0 | - | - | Restricted Stock Unit | |
| Raymond C. Kurzweil | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jul 2025 | 590 | 12,670 (0%) | 0% | 0 | Common Stock | |
| Tommy G. Thompson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2025 | 3,650 | 3,650 | - | - | Stock Options | |
| Christopher Causey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jul 2025 | 1,190 | 0 | - | - | Restricted Stock Unit | |
| Christopher Causey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2025 | 3,650 | 3,650 | - | - | Stock Options | |
| Christopher Causey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jul 2025 | 1,190 | 4,865 (0%) | 0% | 0 | Common Stock | |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 24 Jul 2025 | 11,000 | 47,781 (0%) | 0% | 135.4 | 1,489,620 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jul 2025 | 11,000 | 99,000 | - | - | Stock Option | |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 305.14 per share. | 24 Jul 2025 | 2,254 | 36,781 (0%) | 0% | 305.1 | 687,795 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 304.25 per share. | 24 Jul 2025 | 4,977 | 39,035 (0%) | 0% | 304.3 | 1,514,268 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 303.31 per share. | 24 Jul 2025 | 3,769 | 44,012 (0%) | 0% | 303.3 | 1,143,161 | Common Stock |
| Richard Giltner | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jul 2025 | 1,190 | 0 | - | - | Restricted Stock Unit | |
| Richard Giltner | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jul 2025 | 1,190 | 20,574 (0%) | 0% | 0 | Common Stock | |
| Richard Giltner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2025 | 1,310 | 1,310 | - | - | Restricted Stock Unit | |
| Judy D. Olian | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jul 2025 | 1,190 | 6,845 (0%) | 0% | 0 | Common Stock | |
| Judy D. Olian | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2025 | 1,310 | 1,310 | - | - | Restricted Stock Unit | |
| Judy D. Olian | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jul 2025 | 1,190 | 0 | - | - | Restricted Stock Unit | |
| Nilda Mesa | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2025 | 650 | 650 | - | - | Restricted Stock Units | |
| Nilda Mesa | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2025 | 1,830 | 1,830 | - | - | Stock Options | |
| Nilda Mesa | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jul 2025 | 590 | 5,473 (0%) | 0% | 0 | Common Stock | |
| Nilda Mesa | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jul 2025 | 590 | 0 | - | - | Restricted Stock Units | |
| Linda Maxwell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2025 | 3,650 | 3,650 | - | - | Stock Options | |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 301.20 per share. | 10 Jul 2025 | 1,358 | 36,781 (0%) | 0% | 301.2 | 409,023 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 300.48 per share. | 10 Jul 2025 | 7,738 | 38,139 (0%) | 0% | 300.5 | 2,325,108 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 299.49 per share. | 10 Jul 2025 | 1,304 | 45,877 (0%) | 0% | 299.5 | 390,530 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 297.89 per share. | 10 Jul 2025 | 600 | 47,181 (0%) | 0% | 297.9 | 178,732 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 10 Jul 2025 | 11,000 | 47,781 (0%) | 0% | 135.4 | 1,489,620 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jul 2025 | 11,000 | 110,000 | - | - | Stock Option | |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 26 Jun 2025 | 11,000 | 47,781 (0%) | 0% | 135.4 | 1,489,620 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Jun 2025 | 11,000 | 121,000 | - | - | Stock Option | |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 288.80 per share. | 26 Jun 2025 | 100 | 36,781 (0%) | 0% | 288.8 | 28,880 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 287.92 per share. | 26 Jun 2025 | 1,150 | 36,881 (0%) | 0% | 287.9 | 331,110 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 287.21 per share. | 26 Jun 2025 | 2,334 | 38,031 (0%) | 0% | 287.2 | 670,354 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 286.13 per share. | 26 Jun 2025 | 939 | 40,365 (0%) | 0% | 286.1 | 268,676 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 285.01 per share. | 26 Jun 2025 | 3,940 | 41,304 (0%) | 0% | 285.0 | 1,122,930 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 284.10 per share. | 26 Jun 2025 | 2,537 | 45,244 (0%) | 0% | 284.1 | 720,769 | Common Stock |
| Jan Malcolm | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Jun 2025 | 630 | 630 (0%) | 0% | 0 | Common Stock | |
| Jan Malcolm | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2025 | 1,830 | 1,830 | - | - | Stock Options | |
| Jan Malcolm | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2025 | 650 | 650 | - | - | Restricted Stock Unit | |
| Jan Malcolm | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Jun 2025 | 590 | 0 | - | - | Restricted Stock Unit | |
| Jan Malcolm | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Jun 2025 | 630 | 0 | - | - | Restricted Stock Unit | |
| Jan Malcolm | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Jun 2025 | 590 | 1,220 (0%) | 0% | 0 | Common Stock | |
| Richard Giltner | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2025 | 5,000 | 0 | - | - | Stock Option | |
| Richard Giltner | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 175.43 per share. | 24 Jun 2025 | 5,000 | 22,420 (0%) | 0% | 175.4 | 877,150 | Common Stock |
| Richard Giltner | Director | Sale of securities on an exchange or to another person at price $ 289.60 per share. | 24 Jun 2025 | 3,036 | 19,384 (0%) | 0% | 289.6 | 879,214 | Common Stock |
| Nilda Mesa | Director | Sale of securities on an exchange or to another person at price $ 289.99 per share. | 24 Jun 2025 | 645 | 4,883 (0%) | 0% | 290.0 | 187,045 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 278.41 per share. | 12 Jun 2025 | 1,837 | 44,338 (0%) | 0% | 278.4 | 511,441 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 279.51 per share. | 12 Jun 2025 | 1,425 | 42,913 (0%) | 0% | 279.5 | 398,303 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 280.70 per share. | 12 Jun 2025 | 1,375 | 41,538 (0%) | 0% | 280.7 | 385,957 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 281.56 per share. | 12 Jun 2025 | 4,557 | 36,981 (0%) | 0% | 281.6 | 1,283,063 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 282.27 per share. | 12 Jun 2025 | 200 | 36,781 (0%) | 0% | 282.3 | 56,454 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2025 | 11,000 | 132,000 | - | - | Stock Option | |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 12 Jun 2025 | 11,000 | 47,781 (0%) | 0% | 135.4 | 1,489,620 | Common Stock |