XNAS 07 Oct, 2026 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 117.76 per share. | 02 Oct 2026 | 9,500 | 333,943 (0%) | 0% | 117.8 | 1,118,720 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 542.06 per share. | 02 Oct 2026 | 700 | 333,243 (0%) | 0% | 542.1 | 379,443 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 542.87 per share. | 02 Oct 2026 | 408 | 332,835 (0%) | 0% | 542.9 | 221,492 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 544.17 per share. | 02 Oct 2026 | 1,032 | 331,803 (0%) | 0% | 544.2 | 561,588 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 544.90 per share. | 02 Oct 2026 | 1,280 | 330,523 (0%) | 0% | 544.9 | 697,471 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 546.75 per share. | 02 Oct 2026 | 309 | 330,214 (0%) | 0% | 546.7 | 168,945 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 547.99 per share. | 02 Oct 2026 | 1,171 | 329,043 (0%) | 0% | 548.0 | 641,699 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 548.87 per share. | 02 Oct 2026 | 1,206 | 327,837 (0%) | 0% | 548.9 | 661,943 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 549.59 per share. | 02 Oct 2026 | 757 | 327,080 (0%) | 0% | 549.6 | 416,040 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 550.99 per share. | 02 Oct 2026 | 432 | 326,648 (0%) | 0% | 551.0 | 238,027 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 551.82 per share. | 02 Oct 2026 | 725 | 325,923 (0%) | 0% | 551.8 | 400,067 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 552.86 per share. | 02 Oct 2026 | 160 | 325,763 (0%) | 0% | 552.9 | 88,457 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 554.30 per share. | 02 Oct 2026 | 80 | 325,683 (0%) | 0% | 554.3 | 44,344 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 555.60 per share. | 02 Oct 2026 | 80 | 325,603 (0%) | 0% | 555.6 | 44,448 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 557.43 per share. | 02 Oct 2026 | 240 | 325,363 (0%) | 0% | 557.4 | 133,784 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 558.60 per share. | 02 Oct 2026 | 120 | 325,243 (0%) | 0% | 558.6 | 67,032 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 560.66 per share. | 02 Oct 2026 | 120 | 325,123 (0%) | 0% | 560.7 | 67,279 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 562.35 per share. | 02 Oct 2026 | 40 | 325,083 (0%) | 0% | 562.4 | 22,494 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 563.88 per share. | 02 Oct 2026 | 80 | 325,003 (0%) | 0% | 563.9 | 45,110 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 566.58 per share. | 02 Oct 2026 | 80 | 324,923 (0%) | 0% | 566.6 | 45,326 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 569.90 per share. | 02 Oct 2026 | 240 | 324,683 (0%) | 0% | 569.9 | 136,775 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 570.70 per share. | 02 Oct 2026 | 120 | 324,563 (0%) | 0% | 570.7 | 68,484 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 572.44 per share. | 02 Oct 2026 | 80 | 324,483 (0%) | 0% | 572.4 | 45,795 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 574.22 per share. | 02 Oct 2026 | 40 | 324,443 (0%) | 0% | 574.2 | 22,969 | - |
| Mr. Paul A. Mahon,J.D. | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 146.03 per share. | 01 Oct 2026 | 8,300 | 53,472 (0%) | 0% | 146.0 | 1,212,049 | - |
| Mr. Paul A. Mahon,J.D. | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 558.30 per share. | 01 Oct 2026 | 880 | 52,592 (0%) | 0% | 558.3 | 491,308 | - |
| Mr. Paul A. Mahon,J.D. | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 560.19 per share. | 01 Oct 2026 | 1,480 | 51,112 (0%) | 0% | 560.2 | 829,083 | - |
| Mr. Paul A. Mahon,J.D. | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 561.87 per share. | 01 Oct 2026 | 780 | 50,332 (0%) | 0% | 561.9 | 438,259 | - |
| Mr. Paul A. Mahon,J.D. | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 563.09 per share. | 01 Oct 2026 | 1,480 | 48,852 (0%) | 0% | 563.1 | 833,374 | - |
| Mr. Paul A. Mahon,J.D. | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 566.40 per share. | 01 Oct 2026 | 400 | 48,452 (0%) | 0% | 566.4 | 226,562 | - |
| Mr. Paul A. Mahon,J.D. | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 567.76 per share. | 01 Oct 2026 | 720 | 47,732 (0%) | 0% | 567.8 | 408,788 | - |
| Mr. Paul A. Mahon,J.D. | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 569.15 per share. | 01 Oct 2026 | 739 | 46,993 (0%) | 0% | 569.1 | 420,600 | - |
| Mr. Paul A. Mahon,J.D. | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 570.90 per share. | 01 Oct 2026 | 838 | 46,155 (0%) | 0% | 570.9 | 478,411 | - |
| Mr. Paul A. Mahon,J.D. | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 572.25 per share. | 01 Oct 2026 | 823 | 45,332 (0%) | 0% | 572.2 | 470,961 | - |
| Mr. Paul A. Mahon,J.D. | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 573.15 per share. | 01 Oct 2026 | 160 | 45,172 (0%) | 0% | 573.2 | 91,704 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 117.76 per share. | 01 Oct 2026 | 9,500 | 333,943 (0%) | 0% | 117.8 | 1,118,720 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 560.05 per share. | 01 Oct 2026 | 120 | 333,823 (0%) | 0% | 560.1 | 67,206 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 561.68 per share. | 01 Oct 2026 | 80 | 333,743 (0%) | 0% | 561.7 | 44,934 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 563.31 per share. | 01 Oct 2026 | 160 | 333,583 (0%) | 0% | 563.3 | 90,130 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 567.90 per share. | 01 Oct 2026 | 94 | 333,489 (0%) | 0% | 567.9 | 53,383 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 569.65 per share. | 01 Oct 2026 | 306 | 333,183 (0%) | 0% | 569.7 | 174,314 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 570.55 per share. | 01 Oct 2026 | 534 | 332,649 (0%) | 0% | 570.5 | 304,673 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 571.52 per share. | 01 Oct 2026 | 320 | 332,329 (0%) | 0% | 571.5 | 182,888 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 572.86 per share. | 01 Oct 2026 | 560 | 331,769 (0%) | 0% | 572.9 | 320,803 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 573.62 per share. | 01 Oct 2026 | 280 | 331,489 (0%) | 0% | 573.6 | 160,615 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 574.94 per share. | 01 Oct 2026 | 830 | 330,659 (0%) | 0% | 574.9 | 477,204 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 575.90 per share. | 01 Oct 2026 | 1,346 | 329,313 (0%) | 0% | 575.9 | 775,165 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 576.91 per share. | 01 Oct 2026 | 774 | 328,539 (0%) | 0% | 576.9 | 446,525 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 577.93 per share. | 01 Oct 2026 | 930 | 327,609 (0%) | 0% | 577.9 | 537,477 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 579.02 per share. | 01 Oct 2026 | 320 | 327,289 (0%) | 0% | 579.0 | 185,286 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 580.20 per share. | 01 Oct 2026 | 864 | 326,425 (0%) | 0% | 580.2 | 501,291 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 581.21 per share. | 01 Oct 2026 | 702 | 325,723 (0%) | 0% | 581.2 | 408,012 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 582.24 per share. | 01 Oct 2026 | 520 | 325,203 (0%) | 0% | 582.2 | 302,765 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 583.28 per share. | 01 Oct 2026 | 400 | 324,803 (0%) | 0% | 583.3 | 233,313 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 584.66 per share. | 01 Oct 2026 | 360 | 324,443 (0%) | 0% | 584.7 | 210,478 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 117.76 per share. | 30 Sep 2026 | 9,500 | 333,943 (0%) | 0% | 117.8 | 1,118,720 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 476.14 per share. | 30 Sep 2026 | 161 | 333,782 (0%) | 0% | 476.1 | 76,659 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 477.43 per share. | 30 Sep 2026 | 749 | 333,033 (0%) | 0% | 477.4 | 357,592 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 478.47 per share. | 30 Sep 2026 | 650 | 332,383 (0%) | 0% | 478.5 | 311,004 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 479.67 per share. | 30 Sep 2026 | 359 | 332,024 (0%) | 0% | 479.7 | 172,201 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 480.79 per share. | 30 Sep 2026 | 601 | 331,423 (0%) | 0% | 480.8 | 288,957 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 482.36 per share. | 30 Sep 2026 | 160 | 331,263 (0%) | 0% | 482.4 | 77,177 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 487.79 per share. | 30 Sep 2026 | 80 | 331,183 (0%) | 0% | 487.8 | 39,023 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 495.32 per share. | 30 Sep 2026 | 40 | 331,143 (0%) | 0% | 495.3 | 19,813 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 511.38 per share. | 30 Sep 2026 | 40 | 331,103 (0%) | 0% | 511.4 | 20,455 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 514.90 per share. | 30 Sep 2026 | 80 | 331,023 (0%) | 0% | 514.9 | 41,192 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 517.16 per share. | 30 Sep 2026 | 80 | 330,943 (0%) | 0% | 517.2 | 41,373 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 523.36 per share. | 30 Sep 2026 | 80 | 330,863 (0%) | 0% | 523.4 | 41,869 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 524.62 per share. | 30 Sep 2026 | 80 | 330,783 (0%) | 0% | 524.6 | 41,970 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 526.09 per share. | 30 Sep 2026 | 80 | 330,703 (0%) | 0% | 526.1 | 42,087 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 531.11 per share. | 30 Sep 2026 | 160 | 330,543 (0%) | 0% | 531.1 | 84,978 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 536.52 per share. | 30 Sep 2026 | 160 | 330,383 (0%) | 0% | 536.5 | 85,843 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 537.67 per share. | 30 Sep 2026 | 200 | 330,183 (0%) | 0% | 537.7 | 107,534 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 538.65 per share. | 30 Sep 2026 | 40 | 330,143 (0%) | 0% | 538.7 | 21,546 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 540.78 per share. | 30 Sep 2026 | 480 | 329,663 (0%) | 0% | 540.8 | 259,573 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 541.76 per share. | 30 Sep 2026 | 580 | 329,083 (0%) | 0% | 541.8 | 314,222 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 543.24 per share. | 30 Sep 2026 | 600 | 328,483 (0%) | 0% | 543.2 | 325,947 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 544.05 per share. | 30 Sep 2026 | 840 | 327,643 (0%) | 0% | 544.0 | 457,000 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 545.13 per share. | 30 Sep 2026 | 920 | 326,723 (0%) | 0% | 545.1 | 501,519 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 546.23 per share. | 30 Sep 2026 | 360 | 326,363 (0%) | 0% | 546.2 | 196,644 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 547.30 per share. | 30 Sep 2026 | 400 | 325,963 (0%) | 0% | 547.3 | 218,918 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 548.25 per share. | 30 Sep 2026 | 280 | 325,683 (0%) | 0% | 548.3 | 153,511 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 549.40 per share. | 30 Sep 2026 | 240 | 325,443 (0%) | 0% | 549.4 | 131,855 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 550.47 per share. | 30 Sep 2026 | 400 | 325,043 (0%) | 0% | 550.5 | 220,187 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 551.49 per share. | 30 Sep 2026 | 160 | 324,883 (0%) | 0% | 551.5 | 88,239 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 552.62 per share. | 30 Sep 2026 | 120 | 324,763 (0%) | 0% | 552.6 | 66,315 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 553.78 per share. | 30 Sep 2026 | 113 | 324,650 (0%) | 0% | 553.8 | 62,577 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 554.70 per share. | 30 Sep 2026 | 207 | 324,443 (0%) | 0% | 554.7 | 114,823 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 117.76 per share. | 29 Sep 2026 | 9,500 | 333,943 (0%) | 0% | 117.8 | 1,118,720 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 472.04 per share. | 29 Sep 2026 | 400 | 333,543 (0%) | 0% | 472.0 | 188,818 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 472.97 per share. | 29 Sep 2026 | 449 | 333,094 (0%) | 0% | 473.0 | 212,363 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 473.85 per share. | 29 Sep 2026 | 80 | 333,014 (0%) | 0% | 473.9 | 37,908 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 475.11 per share. | 29 Sep 2026 | 552 | 332,462 (0%) | 0% | 475.1 | 262,263 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 476.10 per share. | 29 Sep 2026 | 1,395 | 331,067 (0%) | 0% | 476.1 | 664,160 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 477.09 per share. | 29 Sep 2026 | 2,135 | 328,932 (0%) | 0% | 477.1 | 1,018,581 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 478.10 per share. | 29 Sep 2026 | 2,309 | 326,623 (0%) | 0% | 478.1 | 1,103,923 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 479.07 per share. | 29 Sep 2026 | 1,200 | 325,423 (0%) | 0% | 479.1 | 574,889 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 479.59 per share. | 29 Sep 2026 | 160 | 325,263 (0%) | 0% | 479.6 | 76,734 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 481.22 per share. | 29 Sep 2026 | 500 | 324,763 (0%) | 0% | 481.2 | 240,612 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 482.28 per share. | 29 Sep 2026 | 120 | 324,643 (0%) | 0% | 482.3 | 57,874 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 486.77 per share. | 29 Sep 2026 | 200 | 324,443 (0%) | 0% | 486.8 | 97,354 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 117.76 per share. | 28 Sep 2026 | 9,500 | 333,943 (0%) | 0% | 117.8 | 1,118,720 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 472.43 per share. | 28 Sep 2026 | 280 | 333,663 (0%) | 0% | 472.4 | 132,280 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 473.28 per share. | 28 Sep 2026 | 600 | 333,063 (0%) | 0% | 473.3 | 283,966 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 474.45 per share. | 28 Sep 2026 | 680 | 332,383 (0%) | 0% | 474.5 | 322,629 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 475.28 per share. | 28 Sep 2026 | 80 | 332,303 (0%) | 0% | 475.3 | 38,022 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 476.68 per share. | 28 Sep 2026 | 160 | 332,143 (0%) | 0% | 476.7 | 76,268 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 477.45 per share. | 28 Sep 2026 | 200 | 331,943 (0%) | 0% | 477.5 | 95,490 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 479.06 per share. | 28 Sep 2026 | 601 | 331,342 (0%) | 0% | 479.1 | 287,913 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 480.18 per share. | 28 Sep 2026 | 1,013 | 330,329 (0%) | 0% | 480.2 | 486,427 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 481.20 per share. | 28 Sep 2026 | 1,354 | 328,975 (0%) | 0% | 481.2 | 651,542 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 482.11 per share. | 28 Sep 2026 | 693 | 328,282 (0%) | 0% | 482.1 | 334,104 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 483.20 per share. | 28 Sep 2026 | 1,539 | 326,743 (0%) | 0% | 483.2 | 743,648 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 484.47 per share. | 28 Sep 2026 | 825 | 325,918 (0%) | 0% | 484.5 | 399,685 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 485.45 per share. | 28 Sep 2026 | 1,315 | 324,603 (0%) | 0% | 485.5 | 638,373 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 486.01 per share. | 28 Sep 2026 | 160 | 324,443 (0%) | 0% | 486.0 | 77,761 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 117.76 per share. | 25 Sep 2026 | 9,500 | 333,943 (0%) | 0% | 117.8 | 1,118,720 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 470.55 per share. | 25 Sep 2026 | 40 | 333,903 (0%) | 0% | 470.6 | 18,822 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 471.84 per share. | 25 Sep 2026 | 200 | 333,703 (0%) | 0% | 471.8 | 94,368 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 472.89 per share. | 25 Sep 2026 | 800 | 332,903 (0%) | 0% | 472.9 | 378,309 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 474.15 per share. | 25 Sep 2026 | 543 | 332,360 (0%) | 0% | 474.1 | 257,462 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 475.28 per share. | 25 Sep 2026 | 1,613 | 330,747 (0%) | 0% | 475.3 | 766,623 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 476.13 per share. | 25 Sep 2026 | 2,744 | 328,003 (0%) | 0% | 476.1 | 1,306,507 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 477.19 per share. | 25 Sep 2026 | 1,280 | 326,723 (0%) | 0% | 477.2 | 610,805 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 478.18 per share. | 25 Sep 2026 | 1,648 | 325,075 (0%) | 0% | 478.2 | 788,042 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 478.95 per share. | 25 Sep 2026 | 632 | 324,443 (0%) | 0% | 479.0 | 302,698 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 117.76 per share. | 24 Sep 2026 | 9,500 | 333,943 (0%) | 0% | 117.8 | 1,118,720 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 469.74 per share. | 24 Sep 2026 | 640 | 333,303 (0%) | 0% | 469.7 | 300,631 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 470.63 per share. | 24 Sep 2026 | 2,603 | 330,700 (0%) | 0% | 470.6 | 1,225,045 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 471.77 per share. | 24 Sep 2026 | 2,160 | 328,540 (0%) | 0% | 471.8 | 1,019,026 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 472.73 per share. | 24 Sep 2026 | 580 | 327,960 (0%) | 0% | 472.7 | 274,184 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 474.01 per share. | 24 Sep 2026 | 437 | 327,523 (0%) | 0% | 474.0 | 207,141 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 475.36 per share. | 24 Sep 2026 | 320 | 327,203 (0%) | 0% | 475.4 | 152,114 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 476.51 per share. | 24 Sep 2026 | 280 | 326,923 (0%) | 0% | 476.5 | 133,424 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 477.58 per share. | 24 Sep 2026 | 360 | 326,563 (0%) | 0% | 477.6 | 171,930 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 478.61 per share. | 24 Sep 2026 | 1,480 | 325,083 (0%) | 0% | 478.6 | 708,337 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 479.52 per share. | 24 Sep 2026 | 600 | 324,483 (0%) | 0% | 479.5 | 287,710 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 480.32 per share. | 24 Sep 2026 | 40 | 324,443 (0%) | 0% | 480.3 | 19,213 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 117.76 per share. | 23 Sep 2026 | 9,500 | 333,943 (0%) | 0% | 117.8 | 1,118,720 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 500.05 per share. | 23 Sep 2026 | 240 | 324,443 (0%) | 0% | 500.1 | 120,012 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 498.90 per share. | 23 Sep 2026 | 90 | 324,683 (0%) | 0% | 498.9 | 44,901 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 498.38 per share. | 23 Sep 2026 | 270 | 324,773 (0%) | 0% | 498.4 | 134,563 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 497.27 per share. | 23 Sep 2026 | 766 | 325,043 (0%) | 0% | 497.3 | 380,908 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 496.38 per share. | 23 Sep 2026 | 525 | 325,809 (0%) | 0% | 496.4 | 260,598 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 495.17 per share. | 23 Sep 2026 | 155 | 326,334 (0%) | 0% | 495.2 | 76,752 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 493.72 per share. | 23 Sep 2026 | 160 | 326,489 (0%) | 0% | 493.7 | 78,996 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 492.54 per share. | 23 Sep 2026 | 480 | 326,649 (0%) | 0% | 492.5 | 236,421 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 491.66 per share. | 23 Sep 2026 | 824 | 327,129 (0%) | 0% | 491.7 | 405,124 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 490.48 per share. | 23 Sep 2026 | 1,440 | 327,953 (0%) | 0% | 490.5 | 706,286 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 489.52 per share. | 23 Sep 2026 | 2,162 | 329,393 (0%) | 0% | 489.5 | 1,058,351 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 488.70 per share. | 23 Sep 2026 | 2,388 | 331,555 (0%) | 0% | 488.7 | 1,167,007 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 117.76 per share. | 22 Sep 2026 | 9,500 | 333,943 (0%) | 0% | 117.8 | 1,118,720 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 499.07 per share. | 22 Sep 2026 | 160 | 324,443 (0%) | 0% | 499.1 | 79,851 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 497.73 per share. | 22 Sep 2026 | 1,358 | 324,603 (0%) | 0% | 497.7 | 675,912 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 496.83 per share. | 22 Sep 2026 | 1,484 | 325,961 (0%) | 0% | 496.8 | 737,295 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 495.77 per share. | 22 Sep 2026 | 1,488 | 327,445 (0%) | 0% | 495.8 | 737,700 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 494.66 per share. | 22 Sep 2026 | 1,337 | 328,933 (0%) | 0% | 494.7 | 661,358 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 493.70 per share. | 22 Sep 2026 | 1,645 | 330,270 (0%) | 0% | 493.7 | 812,139 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 492.67 per share. | 22 Sep 2026 | 628 | 331,915 (0%) | 0% | 492.7 | 309,395 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 491.45 per share. | 22 Sep 2026 | 736 | 332,543 (0%) | 0% | 491.4 | 361,705 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 490.54 per share. | 22 Sep 2026 | 424 | 333,279 (0%) | 0% | 490.5 | 207,988 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 489.61 per share. | 22 Sep 2026 | 240 | 333,703 (0%) | 0% | 489.6 | 117,507 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 496.62 per share. | 21 Sep 2026 | 843 | 324,443 (0%) | 0% | 496.6 | 418,654 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 492.97 per share. | 21 Sep 2026 | 1,520 | 332,423 (0%) | 0% | 493.0 | 749,321 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 117.76 per share. | 21 Sep 2026 | 9,500 | 333,943 (0%) | 0% | 117.8 | 1,118,720 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 495.71 per share. | 21 Sep 2026 | 2,287 | 325,286 (0%) | 0% | 495.7 | 1,133,694 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 494.82 per share. | 21 Sep 2026 | 2,170 | 327,573 (0%) | 0% | 494.8 | 1,073,751 | - |
| Dr. Martine A. Rothblatt, J.D.,M.B.A.,PhD | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 493.60 per share. | 21 Sep 2026 | 2,680 | 329,743 (0%) | 0% | 493.6 | 1,322,851 | - |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 498.25 per share. | 18 Sep 2026 | 160 | 324,443 (0%) | 0% | 498.3 | 79,720 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 496.64 per share. | 18 Sep 2026 | 277 | 324,603 (0%) | 0% | 496.6 | 137,569 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 495.66 per share. | 18 Sep 2026 | 2,330 | 324,880 (0%) | 0% | 495.7 | 1,154,894 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 494.70 per share. | 18 Sep 2026 | 4,269 | 327,210 (0%) | 0% | 494.7 | 2,111,871 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 493.78 per share. | 18 Sep 2026 | 2,216 | 331,479 (0%) | 0% | 493.8 | 1,094,209 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 492.91 per share. | 18 Sep 2026 | 248 | 333,695 (0%) | 0% | 492.9 | 122,241 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 117.76 per share. | 18 Sep 2026 | 9,500 | 333,943 (0%) | 0% | 117.8 | 1,118,720 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Sep 2026 | 9,500 | 404,410 | - | - | Stock Option | |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 496.58 per share. | 17 Sep 2026 | 2,873 | 49,020 (0%) | 0% | 496.6 | 1,426,662 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 146.03 per share. | 17 Sep 2026 | 8,300 | 53,472 (0%) | 0% | 146.0 | 1,212,049 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 117.76 per share. | 17 Sep 2026 | 9,500 | 333,943 (0%) | 0% | 117.8 | 1,118,720 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Sep 2026 | 9,500 | 413,910 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 501.60 per share. | 17 Sep 2026 | 160 | 324,443 (0%) | 0% | 501.6 | 80,256 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 500.09 per share. | 17 Sep 2026 | 468 | 324,603 (0%) | 0% | 500.1 | 234,043 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 499.10 per share. | 17 Sep 2026 | 332 | 325,071 (0%) | 0% | 499.1 | 165,701 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 497.79 per share. | 17 Sep 2026 | 151 | 325,403 (0%) | 0% | 497.8 | 75,166 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 497.17 per share. | 17 Sep 2026 | 1,953 | 325,554 (0%) | 0% | 497.2 | 970,978 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 496.21 per share. | 17 Sep 2026 | 2,182 | 327,507 (0%) | 0% | 496.2 | 1,082,721 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 495.11 per share. | 17 Sep 2026 | 1,905 | 329,689 (0%) | 0% | 495.1 | 943,183 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 494.34 per share. | 17 Sep 2026 | 1,750 | 331,594 (0%) | 0% | 494.3 | 865,096 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 493.22 per share. | 17 Sep 2026 | 599 | 333,344 (0%) | 0% | 493.2 | 295,436 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 495.97 per share. | 17 Sep 2026 | 1,579 | 51,893 (0%) | 0% | 496.0 | 783,132 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Sep 2026 | 8,300 | 47,540 | - | - | Stock Option | |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 501.58 per share. | 17 Sep 2026 | 320 | 45,172 (0%) | 0% | 501.6 | 160,506 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 500.80 per share. | 17 Sep 2026 | 125 | 45,492 (0%) | 0% | 500.8 | 62,600 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 499.75 per share. | 17 Sep 2026 | 1,160 | 45,617 (0%) | 0% | 499.8 | 579,712 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 498.74 per share. | 17 Sep 2026 | 843 | 46,777 (0%) | 0% | 498.7 | 420,435 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 497.54 per share. | 17 Sep 2026 | 1,400 | 47,620 (0%) | 0% | 497.5 | 696,561 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 117.76 per share. | 16 Sep 2026 | 9,500 | 333,943 (0%) | 0% | 117.8 | 1,118,720 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Sep 2026 | 9,500 | 423,410 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 505.20 per share. | 16 Sep 2026 | 120 | 324,443 (0%) | 0% | 505.2 | 60,624 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 504.17 per share. | 16 Sep 2026 | 1,182 | 324,563 (0%) | 0% | 504.2 | 595,932 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 503.53 per share. | 16 Sep 2026 | 1,538 | 325,745 (0%) | 0% | 503.5 | 774,429 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 502.44 per share. | 16 Sep 2026 | 2,160 | 327,283 (0%) | 0% | 502.4 | 1,085,272 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 501.52 per share. | 16 Sep 2026 | 708 | 329,443 (0%) | 0% | 501.5 | 355,077 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 500.20 per share. | 16 Sep 2026 | 492 | 330,151 (0%) | 0% | 500.2 | 246,096 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 499.15 per share. | 16 Sep 2026 | 1,220 | 330,643 (0%) | 0% | 499.2 | 608,966 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 498.45 per share. | 16 Sep 2026 | 2,080 | 331,863 (0%) | 0% | 498.5 | 1,036,777 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 117.76 per share. | 15 Sep 2026 | 9,500 | 333,943 (0%) | 0% | 117.8 | 1,118,720 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 503.80 per share. | 15 Sep 2026 | 845 | 325,093 (0%) | 0% | 503.8 | 425,715 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 504.57 per share. | 15 Sep 2026 | 650 | 324,443 (0%) | 0% | 504.6 | 327,971 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Sep 2026 | 9,500 | 432,910 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 502.57 per share. | 15 Sep 2026 | 825 | 325,938 (0%) | 0% | 502.6 | 414,620 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 501.66 per share. | 15 Sep 2026 | 2,689 | 326,763 (0%) | 0% | 501.7 | 1,348,970 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 500.68 per share. | 15 Sep 2026 | 3,711 | 329,452 (0%) | 0% | 500.7 | 1,858,019 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 499.77 per share. | 15 Sep 2026 | 780 | 333,163 (0%) | 0% | 499.8 | 389,824 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 506.48 per share. | 14 Sep 2026 | 440 | 324,443 (0%) | 0% | 506.5 | 222,851 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 505.25 per share. | 14 Sep 2026 | 2,400 | 324,883 (0%) | 0% | 505.3 | 1,212,609 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 504.47 per share. | 14 Sep 2026 | 2,722 | 327,283 (0%) | 0% | 504.5 | 1,373,180 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 503.44 per share. | 14 Sep 2026 | 2,358 | 330,005 (0%) | 0% | 503.4 | 1,187,113 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 502.15 per share. | 14 Sep 2026 | 1,580 | 332,363 (0%) | 0% | 502.2 | 793,399 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 117.76 per share. | 14 Sep 2026 | 9,500 | 333,943 (0%) | 0% | 117.8 | 1,118,720 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Sep 2026 | 9,500 | 442,410 | - | - | Stock Option | |
| Nilda Mesa | Director | Sale of securities on an exchange or to another person at price $ 505.98 per share. | 14 Sep 2026 | 98 | 5,580 (0%) | 0% | 506.0 | 49,586 | Common Stock |
| Nilda Mesa | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 110.86 per share. | 14 Sep 2026 | 130 | 6,560 (0%) | 0% | 110.9 | 14,412 | Common Stock |
| Nilda Mesa | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Sep 2026 | 130 | 6,430 | - | - | Stock Option | |
| Nilda Mesa | Director | Sale of securities on an exchange or to another person at price $ 505.78 per share. | 14 Sep 2026 | 130 | 6,430 (0%) | 0% | 505.8 | 65,752 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 117.76 per share. | 11 Sep 2026 | 9,500 | 333,943 (0%) | 0% | 117.8 | 1,118,720 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Sep 2026 | 9,500 | 451,910 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 508.21 per share. | 11 Sep 2026 | 280 | 324,443 (0%) | 0% | 508.2 | 142,299 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 507.31 per share. | 11 Sep 2026 | 320 | 324,723 (0%) | 0% | 507.3 | 162,338 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 506.44 per share. | 11 Sep 2026 | 518 | 325,043 (0%) | 0% | 506.4 | 262,336 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 504.96 per share. | 11 Sep 2026 | 82 | 325,561 (0%) | 0% | 505.0 | 41,407 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 503.99 per share. | 11 Sep 2026 | 710 | 325,643 (0%) | 0% | 504.0 | 357,835 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 503.10 per share. | 11 Sep 2026 | 850 | 326,353 (0%) | 0% | 503.1 | 427,634 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 502.13 per share. | 11 Sep 2026 | 1,560 | 327,203 (0%) | 0% | 502.1 | 783,323 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 500.86 per share. | 11 Sep 2026 | 476 | 328,763 (0%) | 0% | 500.9 | 238,409 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 499.61 per share. | 11 Sep 2026 | 204 | 329,239 (0%) | 0% | 499.6 | 101,921 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 498.97 per share. | 11 Sep 2026 | 1,021 | 329,443 (0%) | 0% | 499.0 | 509,446 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 497.99 per share. | 11 Sep 2026 | 2,138 | 330,464 (0%) | 0% | 498.0 | 1,064,700 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 496.74 per share. | 11 Sep 2026 | 1,341 | 332,602 (0%) | 0% | 496.7 | 666,126 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 498.44 per share. | 10 Sep 2026 | 120 | 333,823 (0%) | 0% | 498.4 | 59,813 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2026 | 9,500 | 461,410 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 508.80 per share. | 10 Sep 2026 | 280 | 324,443 (0%) | 0% | 508.8 | 142,465 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 506.76 per share. | 10 Sep 2026 | 280 | 324,723 (0%) | 0% | 506.8 | 141,893 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 505.94 per share. | 10 Sep 2026 | 600 | 325,003 (0%) | 0% | 505.9 | 303,564 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 505.03 per share. | 10 Sep 2026 | 702 | 325,603 (0%) | 0% | 505.0 | 354,533 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 503.76 per share. | 10 Sep 2026 | 578 | 326,305 (0%) | 0% | 503.8 | 291,174 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 502.80 per share. | 10 Sep 2026 | 1,536 | 326,883 (0%) | 0% | 502.8 | 772,300 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 501.88 per share. | 10 Sep 2026 | 2,244 | 328,419 (0%) | 0% | 501.9 | 1,126,209 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 500.58 per share. | 10 Sep 2026 | 1,372 | 330,663 (0%) | 0% | 500.6 | 686,797 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 499.75 per share. | 10 Sep 2026 | 1,788 | 332,035 (0%) | 0% | 499.7 | 893,548 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 117.76 per share. | 10 Sep 2026 | 9,500 | 333,943 (0%) | 0% | 117.8 | 1,118,720 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 509.00 per share. | 09 Sep 2026 | 200 | 324,443 (0%) | 0% | 509 | 101,800 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Sep 2026 | 9,500 | 470,910 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 497.56 per share. | 09 Sep 2026 | 160 | 331,223 (0%) | 0% | 497.6 | 79,609 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 496.73 per share. | 09 Sep 2026 | 1,278 | 331,383 (0%) | 0% | 496.7 | 634,817 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 495.65 per share. | 09 Sep 2026 | 1,202 | 332,661 (0%) | 0% | 495.7 | 595,775 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 493.80 per share. | 09 Sep 2026 | 80 | 333,863 (0%) | 0% | 493.8 | 39,504 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 117.76 per share. | 09 Sep 2026 | 9,500 | 333,943 (0%) | 0% | 117.8 | 1,118,720 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 505.03 per share. | 09 Sep 2026 | 964 | 326,818 (0%) | 0% | 505.0 | 486,847 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 503.60 per share. | 09 Sep 2026 | 1,144 | 327,782 (0%) | 0% | 503.6 | 576,123 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 502.87 per share. | 09 Sep 2026 | 1,017 | 328,926 (0%) | 0% | 502.9 | 511,414 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 506.84 per share. | 09 Sep 2026 | 794 | 325,149 (0%) | 0% | 506.8 | 402,429 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 500.84 per share. | 09 Sep 2026 | 361 | 329,943 (0%) | 0% | 500.8 | 180,803 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 499.73 per share. | 09 Sep 2026 | 519 | 330,304 (0%) | 0% | 499.7 | 259,362 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 505.78 per share. | 09 Sep 2026 | 875 | 325,943 (0%) | 0% | 505.8 | 442,560 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 498.85 per share. | 09 Sep 2026 | 400 | 330,823 (0%) | 0% | 498.8 | 199,539 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 507.68 per share. | 09 Sep 2026 | 506 | 324,643 (0%) | 0% | 507.7 | 256,885 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 117.76 per share. | 08 Sep 2026 | 9,500 | 333,943 (0%) | 0% | 117.8 | 1,118,720 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Sep 2026 | 9,500 | 480,410 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 504.15 per share. | 08 Sep 2026 | 418 | 324,443 (0%) | 0% | 504.1 | 210,733 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 503.33 per share. | 08 Sep 2026 | 701 | 324,861 (0%) | 0% | 503.3 | 352,833 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 502.26 per share. | 08 Sep 2026 | 1,167 | 325,562 (0%) | 0% | 502.3 | 586,135 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 501.17 per share. | 08 Sep 2026 | 1,221 | 326,729 (0%) | 0% | 501.2 | 611,934 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 500.20 per share. | 08 Sep 2026 | 1,173 | 327,950 (0%) | 0% | 500.2 | 586,734 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 498.77 per share. | 08 Sep 2026 | 1,018 | 329,123 (0%) | 0% | 498.8 | 507,746 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 498.18 per share. | 08 Sep 2026 | 1,902 | 330,141 (0%) | 0% | 498.2 | 947,531 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 497.05 per share. | 08 Sep 2026 | 300 | 332,043 (0%) | 0% | 497.1 | 149,115 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 495.75 per share. | 08 Sep 2026 | 256 | 332,343 (0%) | 0% | 495.8 | 126,912 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 494.87 per share. | 08 Sep 2026 | 600 | 332,599 (0%) | 0% | 494.9 | 296,923 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 493.98 per share. | 08 Sep 2026 | 144 | 333,199 (0%) | 0% | 494.0 | 71,133 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 492.71 per share. | 08 Sep 2026 | 140 | 333,343 (0%) | 0% | 492.7 | 68,980 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 491.04 per share. | 08 Sep 2026 | 220 | 333,483 (0%) | 0% | 491.0 | 108,028 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 483.90 per share. | 08 Sep 2026 | 200 | 333,703 (0%) | 0% | 483.9 | 96,780 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 481.90 per share. | 08 Sep 2026 | 40 | 333,903 (0%) | 0% | 481.9 | 19,276 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 490.01 per share. | 04 Sep 2026 | 1,514 | 325,923 (0%) | 0% | 490.0 | 741,874 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 490.94 per share. | 04 Sep 2026 | 1,160 | 324,763 (0%) | 0% | 490.9 | 569,485 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 491.69 per share. | 04 Sep 2026 | 320 | 324,443 (0%) | 0% | 491.7 | 157,342 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Sep 2026 | 9,500 | 489,910 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 117.76 per share. | 04 Sep 2026 | 9,500 | 333,943 (0%) | 0% | 117.8 | 1,118,720 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 485.85 per share. | 04 Sep 2026 | 40 | 333,903 (0%) | 0% | 485.9 | 19,434 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 486.88 per share. | 04 Sep 2026 | 223 | 333,680 (0%) | 0% | 486.9 | 108,574 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 488.08 per share. | 04 Sep 2026 | 2,818 | 330,862 (0%) | 0% | 488.1 | 1,375,398 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 489.12 per share. | 04 Sep 2026 | 3,425 | 327,437 (0%) | 0% | 489.1 | 1,675,248 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2026 | 8,300 | 55,840 | - | - | Stock Option | |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 478.93 per share. | 03 Sep 2026 | 1,545 | 51,927 (0%) | 0% | 478.9 | 739,954 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 479.66 per share. | 03 Sep 2026 | 936 | 50,991 (0%) | 0% | 479.7 | 448,959 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 146.03 per share. | 03 Sep 2026 | 8,300 | 53,472 (0%) | 0% | 146.0 | 1,212,049 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 480.86 per share. | 03 Sep 2026 | 2,360 | 48,631 (0%) | 0% | 480.9 | 1,134,833 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 481.92 per share. | 03 Sep 2026 | 1,048 | 47,583 (0%) | 0% | 481.9 | 505,049 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 482.66 per share. | 03 Sep 2026 | 160 | 47,423 (0%) | 0% | 482.7 | 77,226 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 483.85 per share. | 03 Sep 2026 | 200 | 47,223 (0%) | 0% | 483.9 | 96,770 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 485.12 per share. | 03 Sep 2026 | 954 | 46,269 (0%) | 0% | 485.1 | 462,807 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 486.47 per share. | 03 Sep 2026 | 598 | 45,671 (0%) | 0% | 486.5 | 290,908 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 487.36 per share. | 03 Sep 2026 | 169 | 45,502 (0%) | 0% | 487.4 | 82,364 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 488.30 per share. | 03 Sep 2026 | 10 | 45,492 (0%) | 0% | 488.3 | 4,883 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 490.88 per share. | 03 Sep 2026 | 320 | 45,172 (0%) | 0% | 490.9 | 157,083 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 03 Sep 2026 | 8,910 | 333,353 (0%) | 0% | 135.4 | 1,206,592 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2026 | 8,910 | 0 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 491.24 per share. | 03 Sep 2026 | 42 | 324,443 (0%) | 0% | 491.2 | 20,632 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2026 | 590 | 499,410 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 490.50 per share. | 03 Sep 2026 | 940 | 324,485 (0%) | 0% | 490.5 | 461,070 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 489.62 per share. | 03 Sep 2026 | 3,114 | 325,425 (0%) | 0% | 489.6 | 1,524,667 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 488.68 per share. | 03 Sep 2026 | 1,604 | 328,539 (0%) | 0% | 488.7 | 783,847 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 487.87 per share. | 03 Sep 2026 | 1,429 | 330,143 (0%) | 0% | 487.9 | 697,160 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 486.73 per share. | 03 Sep 2026 | 411 | 331,572 (0%) | 0% | 486.7 | 200,044 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 485.16 per share. | 03 Sep 2026 | 240 | 331,983 (0%) | 0% | 485.2 | 116,438 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 483.69 per share. | 03 Sep 2026 | 80 | 332,223 (0%) | 0% | 483.7 | 38,695 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 482.34 per share. | 03 Sep 2026 | 400 | 332,303 (0%) | 0% | 482.3 | 192,938 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 481.47 per share. | 03 Sep 2026 | 600 | 332,703 (0%) | 0% | 481.5 | 288,884 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 480.52 per share. | 03 Sep 2026 | 440 | 333,303 (0%) | 0% | 480.5 | 211,431 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 479.06 per share. | 03 Sep 2026 | 200 | 333,743 (0%) | 0% | 479.1 | 95,813 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 117.76 per share. | 03 Sep 2026 | 590 | 333,943 (0%) | 0% | 117.8 | 69,478 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2026 | 9,500 | 8,910 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 510.05 per share. | 02 Sep 2026 | 160 | 324,443 (0%) | 0% | 510.1 | 81,608 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 508.36 per share. | 02 Sep 2026 | 80 | 324,603 (0%) | 0% | 508.4 | 40,669 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 506.28 per share. | 02 Sep 2026 | 40 | 324,683 (0%) | 0% | 506.3 | 20,251 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 505.20 per share. | 02 Sep 2026 | 40 | 324,723 (0%) | 0% | 505.2 | 20,208 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 504.15 per share. | 02 Sep 2026 | 200 | 324,763 (0%) | 0% | 504.2 | 100,830 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 502.01 per share. | 02 Sep 2026 | 120 | 324,963 (0%) | 0% | 502.0 | 60,241 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 501.06 per share. | 02 Sep 2026 | 160 | 325,083 (0%) | 0% | 501.1 | 80,170 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 500.22 per share. | 02 Sep 2026 | 54 | 325,243 (0%) | 0% | 500.2 | 27,012 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 498.97 per share. | 02 Sep 2026 | 542 | 325,297 (0%) | 0% | 499.0 | 270,443 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 498.21 per share. | 02 Sep 2026 | 364 | 325,839 (0%) | 0% | 498.2 | 181,347 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 496.95 per share. | 02 Sep 2026 | 777 | 326,203 (0%) | 0% | 496.9 | 386,128 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 495.96 per share. | 02 Sep 2026 | 423 | 326,980 (0%) | 0% | 496.0 | 209,789 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 494.33 per share. | 02 Sep 2026 | 520 | 327,403 (0%) | 0% | 494.3 | 257,051 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 493.59 per share. | 02 Sep 2026 | 520 | 327,923 (0%) | 0% | 493.6 | 256,668 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 492.25 per share. | 02 Sep 2026 | 2,067 | 328,443 (0%) | 0% | 492.3 | 1,017,488 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 491.38 per share. | 02 Sep 2026 | 1,833 | 330,510 (0%) | 0% | 491.4 | 900,704 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 490.19 per share. | 02 Sep 2026 | 560 | 332,343 (0%) | 0% | 490.2 | 274,507 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 489.05 per share. | 02 Sep 2026 | 240 | 332,903 (0%) | 0% | 489.1 | 117,373 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 486.32 per share. | 02 Sep 2026 | 160 | 333,143 (0%) | 0% | 486.3 | 77,811 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 485.12 per share. | 02 Sep 2026 | 120 | 333,303 (0%) | 0% | 485.1 | 58,215 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 482.61 per share. | 02 Sep 2026 | 80 | 333,423 (0%) | 0% | 482.6 | 38,609 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 479.89 per share. | 02 Sep 2026 | 160 | 333,503 (0%) | 0% | 479.9 | 76,782 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 478.85 per share. | 02 Sep 2026 | 160 | 333,663 (0%) | 0% | 478.9 | 76,616 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 477.70 per share. | 02 Sep 2026 | 120 | 333,823 (0%) | 0% | 477.7 | 57,324 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 02 Sep 2026 | 9,500 | 333,943 (0%) | 0% | 135.4 | 1,286,490 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 516.62 per share. | 01 Sep 2026 | 80 | 324,443 (0%) | 0% | 516.6 | 41,330 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Sep 2026 | 9,500 | 18,410 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 514.09 per share. | 01 Sep 2026 | 3,454 | 327,612 (0%) | 0% | 514.1 | 1,775,676 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 514.98 per share. | 01 Sep 2026 | 1,620 | 325,992 (0%) | 0% | 515.0 | 834,272 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 01 Sep 2026 | 9,500 | 333,943 (0%) | 0% | 135.4 | 1,286,490 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 513.12 per share. | 01 Sep 2026 | 1,732 | 331,066 (0%) | 0% | 513.1 | 888,721 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 511.95 per share. | 01 Sep 2026 | 825 | 332,798 (0%) | 0% | 512.0 | 422,359 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 510.72 per share. | 01 Sep 2026 | 320 | 333,623 (0%) | 0% | 510.7 | 163,432 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 516.03 per share. | 01 Sep 2026 | 1,469 | 324,523 (0%) | 0% | 516.0 | 758,049 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 511.75 per share. | 31 Aug 2026 | 1,600 | 325,923 (0%) | 0% | 511.8 | 818,801 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 510.93 per share. | 31 Aug 2026 | 4,217 | 327,523 (0%) | 0% | 510.9 | 2,154,598 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 509.84 per share. | 31 Aug 2026 | 810 | 331,740 (0%) | 0% | 509.8 | 412,967 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 508.92 per share. | 31 Aug 2026 | 794 | 332,550 (0%) | 0% | 508.9 | 404,082 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Aug 2026 | 9,500 | 27,910 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 514.95 per share. | 31 Aug 2026 | 40 | 324,443 (0%) | 0% | 515.0 | 20,598 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 507.84 per share. | 31 Aug 2026 | 599 | 333,344 (0%) | 0% | 507.8 | 304,198 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 31 Aug 2026 | 9,500 | 333,943 (0%) | 0% | 135.4 | 1,286,490 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 514.32 per share. | 31 Aug 2026 | 762 | 324,483 (0%) | 0% | 514.3 | 391,913 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 513.50 per share. | 31 Aug 2026 | 678 | 325,245 (0%) | 0% | 513.5 | 348,154 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 28 Aug 2026 | 9,500 | 333,943 (0%) | 0% | 135.4 | 1,286,490 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Aug 2026 | 9,500 | 37,410 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 524.42 per share. | 28 Aug 2026 | 200 | 324,443 (0%) | 0% | 524.4 | 104,884 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 523.50 per share. | 28 Aug 2026 | 6 | 324,643 (0%) | 0% | 523.5 | 3,141 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 522.40 per share. | 28 Aug 2026 | 517 | 324,649 (0%) | 0% | 522.4 | 270,082 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 521.58 per share. | 28 Aug 2026 | 286 | 325,166 (0%) | 0% | 521.6 | 149,172 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 520.30 per share. | 28 Aug 2026 | 751 | 325,452 (0%) | 0% | 520.3 | 390,743 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 519.19 per share. | 28 Aug 2026 | 412 | 326,203 (0%) | 0% | 519.2 | 213,907 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 518.14 per share. | 28 Aug 2026 | 1,346 | 326,615 (0%) | 0% | 518.1 | 697,421 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 517.11 per share. | 28 Aug 2026 | 1,486 | 327,961 (0%) | 0% | 517.1 | 768,421 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 516.16 per share. | 28 Aug 2026 | 2,386 | 329,447 (0%) | 0% | 516.2 | 1,231,551 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 515.46 per share. | 28 Aug 2026 | 1,630 | 331,833 (0%) | 0% | 515.5 | 840,198 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 514.26 per share. | 28 Aug 2026 | 480 | 333,463 (0%) | 0% | 514.3 | 246,843 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 27 Aug 2026 | 9,500 | 333,943 (0%) | 0% | 135.4 | 1,286,490 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 531.12 per share. | 27 Aug 2026 | 120 | 324,443 (0%) | 0% | 531.1 | 63,734 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 530.08 per share. | 27 Aug 2026 | 755 | 324,563 (0%) | 0% | 530.1 | 400,210 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 529.15 per share. | 27 Aug 2026 | 1,308 | 325,318 (0%) | 0% | 529.1 | 692,128 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 528.29 per share. | 27 Aug 2026 | 1,237 | 326,626 (0%) | 0% | 528.3 | 653,500 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 526.38 per share. | 27 Aug 2026 | 280 | 327,863 (0%) | 0% | 526.4 | 147,385 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 525.62 per share. | 27 Aug 2026 | 376 | 328,143 (0%) | 0% | 525.6 | 197,632 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 524.61 per share. | 27 Aug 2026 | 744 | 328,519 (0%) | 0% | 524.6 | 390,310 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 523.60 per share. | 27 Aug 2026 | 240 | 329,263 (0%) | 0% | 523.6 | 125,664 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 522.40 per share. | 27 Aug 2026 | 280 | 329,503 (0%) | 0% | 522.4 | 146,273 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Aug 2026 | 9,500 | 46,910 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 521.23 per share. | 27 Aug 2026 | 477 | 329,783 (0%) | 0% | 521.2 | 248,629 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 520.23 per share. | 27 Aug 2026 | 1,003 | 330,260 (0%) | 0% | 520.2 | 521,795 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 518.90 per share. | 27 Aug 2026 | 200 | 331,263 (0%) | 0% | 518.9 | 103,779 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 517.07 per share. | 27 Aug 2026 | 280 | 331,463 (0%) | 0% | 517.1 | 144,780 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 515.33 per share. | 27 Aug 2026 | 240 | 331,743 (0%) | 0% | 515.3 | 123,679 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 514.32 per share. | 27 Aug 2026 | 120 | 331,983 (0%) | 0% | 514.3 | 61,718 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 513.40 per share. | 27 Aug 2026 | 704 | 332,103 (0%) | 0% | 513.4 | 361,434 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 512.47 per share. | 27 Aug 2026 | 642 | 332,807 (0%) | 0% | 512.5 | 329,007 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 511.57 per share. | 27 Aug 2026 | 494 | 333,449 (0%) | 0% | 511.6 | 252,718 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 26 Aug 2026 | 9,500 | 333,943 (0%) | 0% | 135.4 | 1,286,490 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 520.62 per share. | 26 Aug 2026 | 400 | 324,483 (0%) | 0% | 520.6 | 208,247 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 519.35 per share. | 26 Aug 2026 | 476 | 324,883 (0%) | 0% | 519.4 | 247,211 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 518.35 per share. | 26 Aug 2026 | 1,790 | 325,359 (0%) | 0% | 518.3 | 927,846 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 517.49 per share. | 26 Aug 2026 | 3,516 | 327,149 (0%) | 0% | 517.5 | 1,819,503 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Aug 2026 | 9,500 | 56,410 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 521.48 per share. | 26 Aug 2026 | 40 | 324,443 (0%) | 0% | 521.5 | 20,859 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 516.70 per share. | 26 Aug 2026 | 1,128 | 330,665 (0%) | 0% | 516.7 | 582,832 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 515.41 per share. | 26 Aug 2026 | 1,591 | 331,793 (0%) | 0% | 515.4 | 820,010 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 514.64 per share. | 26 Aug 2026 | 559 | 333,384 (0%) | 0% | 514.6 | 287,682 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 25 Aug 2026 | 9,500 | 333,943 (0%) | 0% | 135.4 | 1,286,490 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Aug 2026 | 9,500 | 65,910 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 520.50 per share. | 25 Aug 2026 | 80 | 324,443 (0%) | 0% | 520.5 | 41,640 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 519.91 per share. | 25 Aug 2026 | 668 | 324,523 (0%) | 0% | 519.9 | 347,297 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 518.80 per share. | 25 Aug 2026 | 2,387 | 325,191 (0%) | 0% | 518.8 | 1,238,375 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 518.08 per share. | 25 Aug 2026 | 2,004 | 327,578 (0%) | 0% | 518.1 | 1,038,238 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 516.95 per share. | 25 Aug 2026 | 2,332 | 329,582 (0%) | 0% | 516.9 | 1,205,518 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 516.12 per share. | 25 Aug 2026 | 2,029 | 331,914 (0%) | 0% | 516.1 | 1,047,205 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Aug 2026 | 9,500 | 75,410 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 511.63 per share. | 24 Aug 2026 | 3,056 | 329,340 (0%) | 0% | 511.6 | 1,563,538 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 510.52 per share. | 24 Aug 2026 | 1,323 | 332,396 (0%) | 0% | 510.5 | 675,421 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 512.46 per share. | 24 Aug 2026 | 3,592 | 325,748 (0%) | 0% | 512.5 | 1,840,743 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 509.41 per share. | 24 Aug 2026 | 224 | 333,719 (0%) | 0% | 509.4 | 114,108 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 24 Aug 2026 | 9,500 | 333,943 (0%) | 0% | 135.4 | 1,286,490 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 513.35 per share. | 24 Aug 2026 | 1,305 | 324,443 (0%) | 0% | 513.3 | 669,921 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 21 Aug 2026 | 9,500 | 333,943 (0%) | 0% | 135.4 | 1,286,490 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Aug 2026 | 9,500 | 84,910 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 527.71 per share. | 21 Aug 2026 | 200 | 324,443 (0%) | 0% | 527.7 | 105,542 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 526.47 per share. | 21 Aug 2026 | 45 | 324,643 (0%) | 0% | 526.5 | 23,691 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 525.42 per share. | 21 Aug 2026 | 235 | 324,688 (0%) | 0% | 525.4 | 123,474 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 524.35 per share. | 21 Aug 2026 | 625 | 324,923 (0%) | 0% | 524.4 | 327,720 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 523.62 per share. | 21 Aug 2026 | 455 | 325,548 (0%) | 0% | 523.6 | 238,247 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 522.29 per share. | 21 Aug 2026 | 669 | 326,003 (0%) | 0% | 522.3 | 349,411 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 521.28 per share. | 21 Aug 2026 | 371 | 326,672 (0%) | 0% | 521.3 | 193,395 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 520.03 per share. | 21 Aug 2026 | 440 | 327,043 (0%) | 0% | 520.0 | 228,814 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 519.08 per share. | 21 Aug 2026 | 837 | 327,483 (0%) | 0% | 519.1 | 434,474 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 518.14 per share. | 21 Aug 2026 | 1,077 | 328,320 (0%) | 0% | 518.1 | 558,032 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 517.07 per share. | 21 Aug 2026 | 773 | 329,397 (0%) | 0% | 517.1 | 399,695 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 516.15 per share. | 21 Aug 2026 | 1,689 | 330,170 (0%) | 0% | 516.1 | 871,777 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 515.26 per share. | 21 Aug 2026 | 624 | 331,859 (0%) | 0% | 515.3 | 321,524 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 513.85 per share. | 21 Aug 2026 | 271 | 332,483 (0%) | 0% | 513.9 | 139,254 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 512.71 per share. | 21 Aug 2026 | 1,189 | 332,754 (0%) | 0% | 512.7 | 609,617 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Aug 2026 | 9,500 | 94,410 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 20 Aug 2026 | 9,500 | 333,943 (0%) | 0% | 135.4 | 1,286,490 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 518.45 per share. | 20 Aug 2026 | 976 | 332,967 (0%) | 0% | 518.4 | 506,006 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 519.51 per share. | 20 Aug 2026 | 1,504 | 331,463 (0%) | 0% | 519.5 | 781,344 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 520.46 per share. | 20 Aug 2026 | 2,357 | 329,106 (0%) | 0% | 520.5 | 1,226,713 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 521.39 per share. | 20 Aug 2026 | 2,470 | 326,636 (0%) | 0% | 521.4 | 1,287,843 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 522.37 per share. | 20 Aug 2026 | 960 | 325,676 (0%) | 0% | 522.4 | 501,477 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 523.26 per share. | 20 Aug 2026 | 800 | 324,876 (0%) | 0% | 523.3 | 418,607 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 525.10 per share. | 20 Aug 2026 | 240 | 324,636 (0%) | 0% | 525.1 | 126,023 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 526.97 per share. | 20 Aug 2026 | 193 | 324,443 (0%) | 0% | 527.0 | 101,705 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 146.03 per share. | 20 Aug 2026 | 5,610 | 53,472 (0%) | 0% | 146.0 | 819,228 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Aug 2026 | 5,610 | 64,140 | - | - | Stock Option | |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Aug 2026 | 2,690 | 0 | - | - | Stock Option | |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 527.21 per share. | 20 Aug 2026 | 120 | 45,172 (0%) | 0% | 527.2 | 63,265 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 526.38 per share. | 20 Aug 2026 | 400 | 45,292 (0%) | 0% | 526.4 | 210,554 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 525.25 per share. | 20 Aug 2026 | 940 | 45,692 (0%) | 0% | 525.3 | 493,735 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 523.69 per share. | 20 Aug 2026 | 192 | 46,632 (0%) | 0% | 523.7 | 100,548 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 522.78 per share. | 20 Aug 2026 | 850 | 46,824 (0%) | 0% | 522.8 | 444,366 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 522.00 per share. | 20 Aug 2026 | 787 | 47,674 (0%) | 0% | 522.0 | 410,817 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 521.04 per share. | 20 Aug 2026 | 1,819 | 48,461 (0%) | 0% | 521.0 | 947,773 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 520.03 per share. | 20 Aug 2026 | 502 | 50,280 (0%) | 0% | 520.0 | 261,057 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Sale of securities on an exchange or to another person at price $ 524.15 per share. | 20 Aug 2026 | 2,690 | 50,782 (0%) | 0% | 524.2 | 1,409,964 | Common Stock |
| Paul A. Mahon | EVP & GENERAL COUNSEL | Exercise or conversion of derivative security received from the company (such as an option) at price $ 146.03 per share. | 20 Aug 2026 | 2,690 | 47,862 (0%) | 0% | 146.0 | 392,821 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 19 Aug 2026 | 9,500 | 333,943 (0%) | 0% | 135.4 | 1,286,490 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Aug 2026 | 9,500 | 103,910 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 535.21 per share. | 19 Aug 2026 | 80 | 324,443 (0%) | 0% | 535.2 | 42,817 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 532.63 per share. | 19 Aug 2026 | 200 | 324,523 (0%) | 0% | 532.6 | 106,526 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 531.62 per share. | 19 Aug 2026 | 80 | 324,723 (0%) | 0% | 531.6 | 42,530 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 531.00 per share. | 19 Aug 2026 | 201 | 324,803 (0%) | 0% | 531.0 | 106,732 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 529.56 per share. | 19 Aug 2026 | 659 | 325,004 (0%) | 0% | 529.6 | 348,979 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 528.59 per share. | 19 Aug 2026 | 1,200 | 325,663 (0%) | 0% | 528.6 | 634,305 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 527.58 per share. | 19 Aug 2026 | 2,135 | 326,863 (0%) | 0% | 527.6 | 1,126,375 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 526.76 per share. | 19 Aug 2026 | 2,105 | 328,998 (0%) | 0% | 526.8 | 1,108,837 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 525.60 per share. | 19 Aug 2026 | 895 | 331,103 (0%) | 0% | 525.6 | 470,409 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 524.51 per share. | 19 Aug 2026 | 441 | 331,998 (0%) | 0% | 524.5 | 231,309 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 523.65 per share. | 19 Aug 2026 | 1,264 | 332,439 (0%) | 0% | 523.6 | 661,888 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 522.49 per share. | 19 Aug 2026 | 240 | 333,703 (0%) | 0% | 522.5 | 125,397 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 518.19 per share. | 18 Aug 2026 | 1,630 | 324,884 (0%) | 0% | 518.2 | 844,642 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 513.06 per share. | 18 Aug 2026 | 439 | 332,864 (0%) | 0% | 513.1 | 225,234 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 514.18 per share. | 18 Aug 2026 | 1,264 | 331,600 (0%) | 0% | 514.2 | 649,918 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 514.99 per share. | 18 Aug 2026 | 2,333 | 329,267 (0%) | 0% | 515.0 | 1,201,464 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 516.04 per share. | 18 Aug 2026 | 1,880 | 327,387 (0%) | 0% | 516.0 | 970,164 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 18 Aug 2026 | 9,500 | 333,943 (0%) | 0% | 135.4 | 1,286,490 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Aug 2026 | 9,500 | 113,410 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 517.09 per share. | 18 Aug 2026 | 873 | 326,514 (0%) | 0% | 517.1 | 451,419 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 518.65 per share. | 18 Aug 2026 | 441 | 324,443 (0%) | 0% | 518.6 | 228,724 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 509.49 per share. | 18 Aug 2026 | 239 | 333,704 (0%) | 0% | 509.5 | 121,767 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 510.47 per share. | 18 Aug 2026 | 231 | 333,473 (0%) | 0% | 510.5 | 117,919 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 511.59 per share. | 18 Aug 2026 | 170 | 333,303 (0%) | 0% | 511.6 | 86,971 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 507.43 per share. | 17 Aug 2026 | 3,298 | 326,126 (0%) | 0% | 507.4 | 1,673,504 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 508.17 per share. | 17 Aug 2026 | 1,683 | 324,443 (0%) | 0% | 508.2 | 855,254 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Aug 2026 | 9,500 | 122,910 | - | - | Stock Option | |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 506.35 per share. | 17 Aug 2026 | 2,521 | 329,424 (0%) | 0% | 506.4 | 1,276,510 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 501.06 per share. | 17 Aug 2026 | 213 | 333,730 (0%) | 0% | 501.1 | 106,726 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 135.42 per share. | 17 Aug 2026 | 9,500 | 333,943 (0%) | 0% | 135.4 | 1,286,490 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 505.36 per share. | 17 Aug 2026 | 1,238 | 331,945 (0%) | 0% | 505.4 | 625,638 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 504.21 per share. | 17 Aug 2026 | 120 | 333,183 (0%) | 0% | 504.2 | 60,505 | Common Stock |
| Martine A. Rothblatt | Director, Chairperson & CEO | Sale of securities on an exchange or to another person at price $ 502.18 per share. | 17 Aug 2026 | 427 | 333,303 (0%) | 0% | 502.2 | 214,431 | Common Stock |