XNAS 29 Aug, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Ian T. Clark | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Aug 2025 | 7,000 | 7,000 (0%) | 0% | 0 | Common Stock | |
| Timothy P. Walbert | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2025 | 6,650 | 9,780 (0%) | 0% | 0 | Common Stock | |
| Richard A. Meier | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2025 | 6,650 | 127,426 (0%) | 0% | 0 | Common Stock | |
| Willard H. Dere | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2025 | 6,650 | 38,950 (0%) | 0% | 0 | Common Stock | |
| Robert J. Hombach | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2025 | 6,650 | 41,870 (0%) | 0% | 0 | Common Stock | |
| Athena Countouriotis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2025 | 6,650 | 13,550 (0%) | 0% | 0 | Common Stock | |
| Mark Joseph Enyedy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2025 | 6,650 | 13,550 (0%) | 0% | 0 | Common Stock | |
| Maykin Ho | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2025 | 6,650 | 28,010 (0%) | 0% | 0 | Common Stock | |
| Barbara W. Bodem | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2025 | 6,650 | 13,555 (0%) | 0% | 0 | Common Stock | |
| Elizabeth McKee Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2025 | 6,650 | 34,450 (0%) | 0% | 0 | Common Stock | |
| Cristin Hubbard | EVP, Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 59.93 per share. | 20 May 2025 | 2,155 | 30,545 (0%) | 0% | 59.9 | 129,149 | Common Stock |
| Erin Burkhart | GVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 59.31 per share. | 19 May 2025 | 1,786 | 14,173 (0%) | 0% | 59.3 | 105,928 | Common Stock |
| Erin Burkhart | GVP, Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 59.27 per share. | 19 May 2025 | 996 | 15,959 (0%) | 0% | 59.3 | 59,033 | Common Stock |
| Cristin Hubbard | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 54.14 per share. | 02 May 2025 | 273 | 32,973 (0%) | 0% | 54.1 | 14,779 | Common Stock |
| Cristin Hubbard | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 64.92 per share. | 02 May 2025 | 273 | 32,700 (0%) | 0% | 64.9 | 17,723 | Common Stock |
| Erin Burkhart | GVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 71.52 per share. | 19 Mar 2025 | 1,295 | 16,955 (0%) | 0% | 71.5 | 92,618 | Common Stock |
| Cristin Hubbard | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Mar 2025 | 30,880 | 30,880 | - | - | Stock Option (Right to Buy Common Stock) | |
| Gregory R. Friberg | EVP, Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Mar 2025 | 17,750 | 46,810 (0%) | 0% | 0 | Common Stock | |
| Gregory R. Friberg | EVP, Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Mar 2025 | 41,170 | 41,170 | - | - | Stock Option (Right to Buy Common Stock) | |
| Cristin Hubbard | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Mar 2025 | 13,310 | 32,700 (0%) | 0% | 0 | Common Stock | |
| Charles Greg Guyer | EVP, Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 13,310 | 80,838 (0%) | 0% | 0 | Common Stock | |
| G. Eric Davis | EVP, Chief Legal Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 69.44 per share. | 14 Mar 2025 | 16,249 | 69,975 (0%) | 0% | 69.4 | 1,128,331 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 30,020 | 30,020 | - | - | Stock Option (Right to Buy Common Stock) | |
| G. Eric Davis | EVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 12,940 | 82,915 (0%) | 0% | 0 | Common Stock | |
| Brian Mueller R. | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 69.44 per share. | 14 Mar 2025 | 18,497 | 83,141 (0%) | 0% | 69.4 | 1,284,432 | Common Stock |
| Brian Mueller R. | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 38,590 | 38,590 | - | - | Stock Option (Right to Buy Common Stock) | |
| Brian Mueller R. | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 16,640 | 99,781 (0%) | 0% | 0 | Common Stock | |
| Charles Greg Guyer | EVP, Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 69.44 per share. | 14 Mar 2025 | 20,127 | 67,528 (0%) | 0% | 69.4 | 1,397,619 | Common Stock |
| Charles Greg Guyer | EVP, Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 30,880 | 30,880 | - | - | Stock Option (Right to Buy Common Stock) | |
| Erin Burkhart | GVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 9,230 | 9,230 | - | - | Stock Option (Right to Buy Common Stock) | |
| Erin Burkhart | GVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 5,970 | 18,252 (0%) | 0% | 0 | Common Stock | |
| Erin Burkhart | GVP, Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 69.44 per share. | 14 Mar 2025 | 823 | 12,282 (0%) | 0% | 69.4 | 57,149 | Common Stock |
| Alexander Hardy | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 61,750 | 61,750 | - | - | Stock Option (Right to Buy Common Stock) | |
| Alexander Hardy | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 69.44 per share. | 14 Mar 2025 | 2,933 | 131,223 (0%) | 0% | 69.4 | 203,668 | Common Stock |
| Alexander Hardy | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 44,360 | 175,583 (0%) | 0% | 0 | Common Stock | |
| Charles Greg Guyer | EVP, Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 71.28 per share. | 06 Mar 2025 | 7,034 | 87,655 (0%) | 0% | 71.3 | 501,355 | Common Stock |
| Charles Greg Guyer | EVP, Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 71.16 per share. | 28 Feb 2025 | 4,287 | 94,689 (0%) | 0% | 71.2 | 305,063 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2025 | 11,040 | 67,197 (0%) | 0% | 0 | Common Stock | |
| Charles Greg Guyer | EVP, Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2025 | 9,367 | 98,976 (0%) | 0% | 0 | Common Stock | |
| Charles Greg Guyer | EVP, Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2025 | 9,660 | 89,609 (0%) | 0% | 0 | Common Stock | |
| Charles Greg Guyer | EVP, Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2025 | 11,040 | 79,949 (0%) | 0% | 0 | Common Stock | |
| Brian Mueller R. | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2025 | 9,660 | 92,271 (0%) | 0% | 0 | Common Stock | |
| Brian Mueller R. | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2025 | 11,040 | 82,611 (0%) | 0% | 0 | Common Stock | |
| Brian Mueller R. | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2025 | 9,367 | 101,638 (0%) | 0% | 0 | Common Stock | |
| G. Eric Davis | EVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2025 | 9,367 | 86,224 (0%) | 0% | 0 | Common Stock | |
| G. Eric Davis | EVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2025 | 9,660 | 76,857 (0%) | 0% | 0 | Common Stock | |
| Timothy P. Walbert | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2025 | 3,130 | 3,130 (0%) | 0% | 0 | Common Stock | |
| Erin Burkhart | GVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 68.38 per share. | 24 Feb 2025 | 1,344 | 13,105 (0%) | 0% | 68.4 | 91,903 | Common Stock |
| Hardy Alexander | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 56.01 per share. | 29 Nov 2024 | 300 | 148,451 (0%) | 0% | 56.0 | 16,802 | Common Stock |
| Hardy Alexander | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 66.03 per share. | 29 Nov 2024 | 14,295 | 134,156 (0%) | 0% | 66.0 | 943,899 | Common Stock |
| Charles Greg Guyer | EVP, Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 66.37 per share. | 12 Nov 2024 | 5,278 | 68,909 (0%) | 0% | 66.4 | 350,324 | Common Stock |
| Charles Greg Guyer | EVP, Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 56.00 per share. | 12 Nov 2024 | 55 | 74,187 (0%) | 0% | 56 | 3,080 | Common Stock |
| Gregory R. Friberg | EVP, Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2024 | 7,870 | 29,060 (0%) | 0% | 0 | Common Stock | |
| Gregory R. Friberg | EVP, Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2024 | 49,850 | 49,850 | - | - | Stock Option (Right to Buy Common Stock) | |
| Gregory R. Friberg | EVP, Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2024 | 21,190 | 21,190 (0%) | 0% | 0 | Common Stock | |
| Henry J. Fuchs | President, Worldwide R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 84.90 per share. | 13 Sep 2024 | 12,098 | 185,074 (0%) | 0% | 84.9 | 1,027,120 | Common Stock |
| Henry J. Fuchs | President, Worldwide R&D | Grant, award, or other acquisition of securities at price $ 68.65 per share. | 13 Sep 2024 | 300 | 197,172 (0%) | 0% | 68.6 | 20,594 | Common Stock |
| Erin Burkhart | GVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 90.00 per share. | 13 Aug 2024 | 714 | 14,449 (0%) | 0% | 90 | 64,260 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 82.33 per share. | 28 Jun 2024 | 588 | 71,571 (0%) | 0% | 82.3 | 48,410 | Common Stock |
| Richard A. Meier | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jun 2024 | 6,600 | 0 | - | - | Stock Option (Right to Buy Common Stock) | |
| Richard A. Meier | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.10 per share. | 03 Jun 2024 | 6,600 | 126,227 (0%) | 0% | 63.1 | 416,460 | Common Stock |
| Richard A. Meier | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 76.41 per share. | 03 Jun 2024 | 5,451 | 120,776 (0%) | 0% | 76.4 | 416,511 | Common Stock |
| Elaine J. Heron | Director | 03 Jun 2024 | 4,168 | 97,720 (0%) | 0% | 76.4 | 318,477 | Common Stock | |
| Elaine J. Heron | Director | 03 Jun 2024 | 5,047 | 0 | - | - | Stock Option (Right to Buy Common Stock) | ||
| Elaine J. Heron | Director | 03 Jun 2024 | 5,047 | 101,888 (0%) | 0% | 63.1 | 318,466 | Common Stock | |
| Brian Mueller | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 75.19 per share. | 30 May 2024 | 5,000 | 72,159 (0%) | 0% | 75.2 | 375,950 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.10 per share. | 30 May 2024 | 5,000 | 77,159 (0%) | 0% | 63.1 | 315,500 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 May 2024 | 5,000 | 0 | - | - | Stock Option (Right to Buy Common Stock) | |
| Brian Mueller | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 68.65 per share. | 30 May 2024 | 300 | 72,159 (0%) | 0% | 68.6 | 20,594 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 40,850 | 0 | - | - | Stock Option (Right to Buy Common Stock) | |
| G. Eric Davis | EVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 75.29 per share. | 28 May 2024 | 2,779 | 56,157 (0%) | 0% | 75.3 | 209,225 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 74.45 per share. | 28 May 2024 | 38,071 | 58,936 (0%) | 0% | 74.5 | 2,834,576 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.10 per share. | 28 May 2024 | 40,850 | 97,007 (0%) | 0% | 63.1 | 2,577,635 | Common Stock |
| Elaine J. Heron | Director | 21 May 2024 | 4,720 | 96,841 (0%) | 0% | 0 | Common Stock | ||
| Richard A. Meier | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2024 | 7,080 | 119,627 (0%) | 0% | 0 | Common Stock | |
| Willard H. Dere | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2024 | 4,720 | 32,300 (0%) | 0% | 0 | Common Stock | |
| David E.I. Pyott | Director | 21 May 2024 | 4,720 | 49,750 (0%) | 0% | 0 | Common Stock | ||
| Robert J. Hombach | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2024 | 4,720 | 35,220 (0%) | 0% | 0 | Common Stock | |
| Athena Countouriotis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2024 | 4,720 | 6,900 (0%) | 0% | 0 | Common Stock | |
| Mark Joseph Enyedy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2024 | 4,720 | 6,900 (0%) | 0% | 0 | Common Stock | |
| Maykin Ho | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2024 | 4,720 | 21,360 (0%) | 0% | 0 | Common Stock | |
| Barbara W. Bodem | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2024 | 4,720 | 6,900 (0%) | 0% | 0 | Common Stock | |
| Elizabeth McKee Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2024 | 4,720 | 27,800 (0%) | 0% | 0 | Common Stock | |
| Jean-Jacques Bienaime | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 77.05 per share. | 20 May 2024 | 1,202 | 473,792 (0%) | 0% | 77.0 | 92,614 | Common Stock |
| Cristin Hubbard | EVP, Chief Commercial Officer | 20 May 2024 | 14,690 | 14,690 (0%) | 0% | 0 | Common Stock | ||
| Cristin Hubbard | EVP, Chief Commercial Officer | 20 May 2024 | 4,700 | 19,390 (0%) | 0% | 0 | Common Stock | ||
| Cristin Hubbard | EVP, Chief Commercial Officer | 20 May 2024 | 33,520 | 33,520 | - | - | Stock Option (Right to Buy Common Stock) | ||
| Erin Burkhart | GVP, Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 76.97 per share. | 17 May 2024 | 993 | 15,163 (0%) | 0% | 77.0 | 76,431 | Common Stock |
| Jean-Jacques Bienaime | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.10 per share. | 09 May 2024 | 20,000 | 494,994 (0%) | 0% | 63.1 | 1,262,000 | Common Stock |
| Jean-Jacques Bienaime | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 May 2024 | 20,000 | 51,000 | - | - | Stock Option (Right to Buy Common Stock) | |
| Jean-Jacques Bienaime | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 May 2024 | 20,000 | 71,000 | - | - | Stock Option (Right to Buy Common Stock) | |
| Jean-Jacques Bienaime | Director | Sale of securities on an exchange or to another person at price $ 81.14 per share. | 09 May 2024 | 20,000 | 474,994 (0%) | 0% | 81.1 | 1,622,800 | Common Stock |
| Jean-Jacques Bienaime | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.10 per share. | 09 May 2024 | 20,000 | 494,994 (0%) | 0% | 63.1 | 1,262,000 | Common Stock |
| Jean-Jacques Bienaime | Director | Sale of securities on an exchange or to another person at price $ 81.62 per share. | 09 May 2024 | 20,000 | 474,994 (0%) | 0% | 81.6 | 1,632,400 | Common Stock |
| Charles Greg Guyer | EVP, Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 68.64 per share. | 03 May 2024 | 245 | 78,572 (0%) | 0% | 68.6 | 16,818 | Common Stock |
| Charles Greg Guyer | EVP, Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 82.44 per share. | 03 May 2024 | 4,440 | 74,132 (0%) | 0% | 82.4 | 366,034 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 May 2024 | 1,850 | 40,850 | - | - | Stock Option (Right to Buy Common Stock) | |
| G. Eric Davis | EVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 85.01 per share. | 02 May 2024 | 1,850 | 56,157 (0%) | 0% | 85.0 | 157,269 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.10 per share. | 02 May 2024 | 1,850 | 58,007 (0%) | 0% | 63.1 | 116,735 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 68.64 per share. | 02 May 2024 | 301 | 56,157 (0%) | 0% | 68.6 | 20,662 | Common Stock |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 82.91 per share. | 02 May 2024 | 5,000 | 66,767 (0%) | 0% | 82.9 | 414,550 | Common Stock |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 68.65 per share. | 02 May 2024 | 300 | 71,767 (0%) | 0% | 68.6 | 20,594 | Common Stock |
| Jean-Jacques Bienaime | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.10 per share. | 11 Apr 2024 | 20,000 | 494,994 (0%) | 0% | 63.1 | 1,262,000 | Common Stock |
| Jean-Jacques Bienaime | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Apr 2024 | 20,000 | 91,000 | - | - | Stock Option (Right to Buy Common Stock) | |
| Jean-Jacques Bienaime | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Apr 2024 | 20,000 | 111,000 | - | - | Stock Option (Right to Buy Common Stock) | |
| Jean-Jacques Bienaime | Director | Sale of securities on an exchange or to another person at price $ 91.26 per share. | 11 Apr 2024 | 20,000 | 474,994 (0%) | 0% | 91.3 | 1,825,200 | Common Stock |
| Jean-Jacques Bienaime | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.10 per share. | 11 Apr 2024 | 20,000 | 494,994 (0%) | 0% | 63.1 | 1,262,000 | Common Stock |
| Jean-Jacques Bienaime | Director | Sale of securities on an exchange or to another person at price $ 90.99 per share. | 11 Apr 2024 | 20,000 | 474,994 (0%) | 0% | 91.0 | 1,819,800 | Common Stock |
| Erin Burkhart | GVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 90.00 per share. | 10 Apr 2024 | 2,286 | 16,156 (0%) | 0% | 90 | 205,740 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 88.34 per share. | 28 Mar 2024 | 24,602 | 55,856 (0%) | 0% | 88.3 | 2,173,341 | Common Stock |
| Dennis J. Slamon | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 79.70 per share. | 18 Mar 2024 | 10,000 | 40,809 (0%) | 0% | 79.7 | 797,000 | Common Stock |
| Dennis J. Slamon | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Mar 2024 | 10,000 | 0 | - | - | Stock Option (Right to Buy Common Stock) | |
| Dennis J. Slamon | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 83.81 per share. | 18 Mar 2024 | 9,510 | 31,299 (0%) | 0% | 83.8 | 797,033 | Common Stock |
| Henry J. Fuchs | President, Worldwide R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2024 | 40,860 | 40,860 | - | - | Stock Option (Right to Buy Common Stock) | |
| Henry J. Fuchs | President, Worldwide R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2024 | 18,240 | 230,357 (0%) | 0% | 0 | Common Stock | |
| Henry J. Fuchs | President, Worldwide R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 83.87 per share. | 15 Mar 2024 | 33,485 | 196,872 (0%) | 0% | 83.9 | 2,808,387 | Common Stock |
| Jean-Jacques Bienaime | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 83.87 per share. | 15 Mar 2024 | 85,209 | 474,994 (0%) | 0% | 83.9 | 7,146,479 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2024 | 10,260 | 102,157 (0%) | 0% | 0 | Common Stock | |
| G. Eric Davis | EVP, Chief Legal Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 83.87 per share. | 15 Mar 2024 | 21,699 | 80,458 (0%) | 0% | 83.9 | 1,819,895 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2024 | 22,990 | 22,990 | - | - | Stock Option (Right to Buy Common Stock) | |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 83.87 per share. | 15 Mar 2024 | 22,580 | 71,467 (0%) | 0% | 83.9 | 1,893,785 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2024 | 25,540 | 25,540 | - | - | Stock Option (Right to Buy Common Stock) | |
| Brian Mueller | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 83.87 per share. | 15 Mar 2024 | 20,789 | 71,859 (0%) | 0% | 83.9 | 1,743,573 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2024 | 11,400 | 92,648 (0%) | 0% | 0 | Common Stock | |
| Charles Greg Guyer | EVP, Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2024 | 10,550 | 98,751 (0%) | 0% | 0 | Common Stock | |
| Charles Greg Guyer | EVP, Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2024 | 23,630 | 23,630 | - | - | Stock Option (Right to Buy Common Stock) | |
| Charles Greg Guyer | EVP, Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 83.87 per share. | 15 Mar 2024 | 20,424 | 78,327 (0%) | 0% | 83.9 | 1,712,961 | Common Stock |
| Erin Burkhart | GVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2024 | 4,720 | 18,814 (0%) | 0% | 0 | Common Stock | |
| Erin Burkhart | GVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2024 | 7,050 | 7,050 | - | - | Stock Option (Right to Buy Common Stock) | |
| Erin Burkhart | GVP, Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 83.87 per share. | 15 Mar 2024 | 372 | 18,442 (0%) | 0% | 83.9 | 31,200 | Common Stock |
| Alexander Hardy | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2024 | 32,780 | 148,151 (0%) | 0% | 0 | Common Stock | |
| Alexander Hardy | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2024 | 44,050 | 44,050 | - | - | Stock Option (Right to Buy Common Stock) | |
| Henry J. Fuchs | President, Worldwide R&D | Sale of securities on an exchange or to another person at price $ 85.18 per share. | 05 Mar 2024 | 35,341 | 212,117 (0%) | 0% | 85.2 | 3,010,396 | Common Stock |
| Jean-Jacques Bienaime | Director | Sale of securities on an exchange or to another person at price $ 85.51 per share. | 05 Mar 2024 | 1,000 | 561,203 (0%) | 0% | 85.5 | 85,510 | Common Stock |
| Jean-Jacques Bienaime | Director | Sale of securities on an exchange or to another person at price $ 86.71 per share. | 05 Mar 2024 | 1,000 | 560,203 (0%) | 0% | 86.7 | 86,713 | Common Stock |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 87.07 per share. | 05 Mar 2024 | 4,000 | 94,047 (0%) | 0% | 87.1 | 348,280 | Common Stock |
| Eric Davis G. | EVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 9,063 | 85,613 (0%) | 0% | 0 | Common Stock | |
| Mueller Brian | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 6,103 | 81,248 (0%) | 0% | 0 | Common Stock | |
| Greg Charles Guyer | EVP, Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 20,840 | 72,854 (0%) | 0% | 0 | Common Stock | |
| Jean-Jacques Bienaime | Director | Sale of securities on an exchange or to another person at price $ 90.35 per share. | 27 Feb 2024 | 1,000 | 562,203 (0%) | 0% | 90.4 | 90,350 | Common Stock |
| Guyer Greg Charles | EVP, Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 6,284 | 88,201 (0%) | 0% | 0 | Common Stock | |
| Fuchs Henry J. | President, Worldwide R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 13,326 | 238,220 (0%) | 0% | 0 | Common Stock | |
| Greg Charles Guyer | EVP, Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 9,063 | 81,917 (0%) | 0% | 0 | Common Stock | |
| R. Ajer Jeffrey | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 21,440 | 82,244 (0%) | 0% | 0 | Common Stock | |
| Jean-Jacques Bienaime | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 35,975 | 538,277 (0%) | 0% | 0 | Common Stock | |
| R. Ajer Jeffrey | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 9,338 | 91,582 (0%) | 0% | 0 | Common Stock | |
| Henry Fuchs J. | President, Worldwide R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 30,640 | 224,894 (0%) | 0% | 0 | Common Stock | |
| Brian Mueller | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 20,220 | 66,343 (0%) | 0% | 0 | Common Stock | |
| Bienaime Jean-Jacques | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 24,926 | 563,203 (0%) | 0% | 0 | Common Stock | |
| Eric Davis G. | EVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 20,840 | 76,550 (0%) | 0% | 0 | Common Stock | |
| Jean-Jacques Bienaime | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 82,700 | 502,302 (0%) | 0% | 0 | Common Stock | |
| Fuchs Henry J. | President, Worldwide R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 9,238 | 247,458 (0%) | 0% | 0 | Common Stock | |
| Brian Mueller | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 8,802 | 75,145 (0%) | 0% | 0 | Common Stock | |
| Eric G. Davis | EVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 6,284 | 91,897 (0%) | 0% | 0 | Common Stock | |
| Ajer R. Jeffrey | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 6,465 | 98,047 (0%) | 0% | 0 | Common Stock | |
| Jean-Jacques Bienaime | Director | Sale of securities on an exchange or to another person at price $ 88.28 per share. | 18 Jan 2024 | 15,000 | 419,602 (0%) | 0% | 88.3 | 1,324,200 | Common Stock |
| Bienaime Jean-Jacques | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.10 per share. | 18 Jan 2024 | 15,000 | 434,602 (0%) | 0% | 63.1 | 946,500 | Common Stock |
| Bienaime Jean-Jacques | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Jan 2024 | 15,000 | 146,000 | - | - | Stock Option (Right to Buy Common Stock) | |
| Jean-Jacques Bienaime | Director | 18 Jan 2024 | 40 | 419,602 (0%) | 0% | 92.6 | 3,704 | Common Stock | |
| Jean-Jacques Bienaime | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.10 per share. | 18 Jan 2024 | 15,000 | 434,602 (0%) | 0% | 63.1 | 946,500 | Common Stock |
| Jean-Jacques Bienaime | Director | Sale of securities on an exchange or to another person at price $ 89.77 per share. | 18 Jan 2024 | 15,000 | 419,602 (0%) | 0% | 89.8 | 1,346,550 | Common Stock |
| Bienaime Jean-Jacques | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Jan 2024 | 15,000 | 131,000 | - | - | Stock Option (Right to Buy Common Stock) | |
| Bienaime Jean-Jacques | Director | Sale of securities on an exchange or to another person at price $ 96.38 per share. | 08 Jan 2024 | 10,000 | 425,162 (0%) | 0% | 96.4 | 963,800 | Common Stock |
| Bienaime Jean-Jacques | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.10 per share. | 08 Jan 2024 | 10,000 | 435,162 (0%) | 0% | 63.1 | 631,000 | Common Stock |
| Jean-Jacques Bienaime | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jan 2024 | 10,000 | 161,000 | - | - | Stock Option (Right to Buy Common Stock) | |
| Jean-Jacques Bienaime | Director | Sale of securities on an exchange or to another person at price $ 98.19 per share. | 08 Jan 2024 | 10,000 | 425,162 (0%) | 0% | 98.2 | 981,900 | Common Stock |
| Jean-Jacques Bienaime | Director | 08 Jan 2024 | 50 | 425,162 (0%) | 0% | 99.1 | 4,953 | Common Stock | |
| Bienaime Jean-Jacques | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jan 2024 | 10,000 | 171,000 | - | - | Stock Option (Right to Buy Common Stock) | |
| Richard Meier A. | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 08 Jan 2024 | 3,000 | 112,547 (0%) | 0% | 0 | Common Stock | |
| Jean-Jacques Bienaime | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.10 per share. | 08 Jan 2024 | 10,000 | 435,162 (0%) | 0% | 63.1 | 631,000 | Common Stock |
| Mueller Brian | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 66.88 per share. | 31 Dec 2023 | 318 | 46,123 (0%) | 0% | 66.9 | 21,267 | Common Stock |
| Jean-Jacques Bienaime | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2023 | 4,400 | 419,762 (0%) | 0% | 0 | Common Stock | |
| Jean-Jacques Bienaime | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2023 | 1,000 | 424,162 (0%) | 0% | 0 | Common Stock | |
| Bienaime Jean-Jacques | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2023 | 200 | 419,562 (0%) | 0% | 0 | Common Stock | |
| Barbara Bodem W. | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Dec 2023 | 2,180 | 2,180 (0%) | 0% | 0 | Common Stock | |
| Joseph Enyedy Mark | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Dec 2023 | 2,180 | 2,180 (0%) | 0% | 0 | Common Stock | |
| Athena Countouriotis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Dec 2023 | 2,180 | 2,180 (0%) | 0% | 0 | Common Stock | |
| Jean-Jacques Bienaime | Director | Sale of securities on an exchange or to another person at price $ 93.99 per share. | 21 Dec 2023 | 10,000 | 425,112 (0%) | 0% | 94.0 | 939,900 | Common Stock |
| Bienaime Jean-Jacques | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Dec 2023 | 10,000 | 181,000 | - | - | Stock Option (Right to Buy Common Stock) | |
| Jean-Jacques Bienaime | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.10 per share. | 21 Dec 2023 | 10,000 | 435,112 (0%) | 0% | 63.1 | 631,000 | Common Stock |
| Davis G. Eric | EVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 95.30 per share. | 13 Dec 2023 | 13,764 | 55,710 (0%) | 0% | 95.3 | 1,311,709 | Common Stock |
| Hardy Alexander | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2023 | 47,332 | 115,371 (0%) | 0% | 0 | Common Stock | |
| J. Henry Fuchs | President, Worldwide R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2023 | 17,750 | 194,254 (0%) | 0% | 0 | Common Stock | |
| Greg Guyer Charles | EVP, Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2023 | 11,840 | 52,014 (0%) | 0% | 0 | Common Stock | |
| Alexander Hardy | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2023 | 68,039 | 68,039 (0%) | 0% | 0 | Common Stock | |
| Hardy Alexander | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2023 | 150,529 | 150,529 | - | - | Stock Option (Right to Buy Common Stock) | |
| Charles Greg Guyer | EVP, Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 69.23 per share. | 01 Dec 2023 | 133 | 40,174 (0%) | 0% | 69.2 | 9,208 | Common Stock |
| J. Henry Fuchs | President, Worldwide R&D | Grant, award, or other acquisition of securities at price $ 66.88 per share. | 01 Dec 2023 | 317 | 176,504 (0%) | 0% | 66.9 | 21,200 | Common Stock |
| Bienaime Jean-Jacques | Director | 04 Oct 2023 | 10 | 422,742 (0%) | 0% | 85.6 | 856 | Common Stock | |
| Jean-Jacques Bienaime | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Oct 2023 | 2,370 | 425,112 (0%) | 0% | 0 | Common Stock | |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 90.00 per share. | 16 Aug 2023 | 5,000 | 60,804 (0%) | 0% | 90 | 450,000 | Common Stock |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 66.88 per share. | 16 Aug 2023 | 318 | 65,804 (0%) | 0% | 66.9 | 21,267 | Common Stock |
| Henry J. Fuchs | President, Worldwide R&D | Sale of securities on an exchange or to another person at price $ 90.43 per share. | 10 Aug 2023 | 12,000 | 176,187 (0%) | 0% | 90.4 | 1,085,111 | Common Stock |
| Charles Greg Guyer | EVP, Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 93.30 per share. | 09 Aug 2023 | 5,360 | 40,041 (0%) | 0% | 93.3 | 500,109 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 89.42 per share. | 08 Aug 2023 | 11,000 | 69,474 (0%) | 0% | 89.4 | 983,662 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 88.29 per share. | 07 Aug 2023 | 6,000 | 422,732 (0%) | 0% | 88.3 | 529,740 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 88.10 per share. | 07 Aug 2023 | 4,000 | 428,732 (0%) | 0% | 88.1 | 352,400 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 88.93 per share. | 29 Jun 2023 | 4,602 | 50,983 (0%) | 0% | 88.9 | 409,256 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 88.93 per share. | 29 Jun 2023 | 576 | 45,805 (0%) | 0% | 88.9 | 51,224 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 88.93 per share. | 29 Jun 2023 | 4,602 | 46,381 (0%) | 0% | 88.9 | 409,256 | Common Stock |
| Elaine J. Heron | Director | 23 May 2023 | 4,190 | 92,121 (0%) | 0% | 0 | Common Stock | ||
| Richard A. Meier | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2023 | 4,190 | 115,547 (0%) | 0% | 0 | Common Stock | |
| Willard H. Dere | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2023 | 4,190 | 27,580 (0%) | 0% | 0 | Common Stock | |
| David E.I. Pyott | Director | 23 May 2023 | 4,190 | 45,030 (0%) | 0% | 0 | Common Stock | ||
| V. Bryan Lawlis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2023 | 4,190 | 33,140 (0%) | 0% | 0 | Common Stock | |
| Robert J. Hombach | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2023 | 4,190 | 30,500 (0%) | 0% | 0 | Common Stock | |
| Mark J. Alles | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2023 | 4,190 | 15,095 (0%) | 0% | 0 | Common Stock | |
| Dennis J. Slamon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2023 | 4,190 | 30,809 (0%) | 0% | 0 | Common Stock | |
| Maykin Ho | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2023 | 4,190 | 16,640 (0%) | 0% | 0 | Common Stock | |
| Elizabeth McKee Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2023 | 4,190 | 23,080 (0%) | 0% | 0 | Common Stock | |
| Erin Burkhart | GVP, Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 92.02 per share. | 16 May 2023 | 796 | 14,094 (0%) | 0% | 92.0 | 73,248 | Common Stock |
| Elaine J. Heron | Director | 12 May 2023 | 8,500 | 94,068 (0%) | 0% | 67.8 | 576,385 | Common Stock | |
| Elaine J. Heron | Director | 12 May 2023 | 8,500 | 0 | - | - | Stock Option (Right to Buy Common Stock) | ||
| Elaine J. Heron | Director | 12 May 2023 | 6,137 | 87,931 (0%) | 0% | 93.9 | 576,448 | Common Stock | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 May 2023 | 7,370 | 0 | - | - | Stock Option (Right to Buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 12 May 2023 | 39,130 | 465,343 (0%) | 0% | 67.8 | 2,653,405 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 12 May 2023 | 7,370 | 472,713 (0%) | 0% | 67.8 | 499,760 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 93.93 per share. | 12 May 2023 | 6,337 | 466,376 (0%) | 0% | 93.9 | 595,234 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 93.93 per share. | 12 May 2023 | 33,644 | 432,732 (0%) | 0% | 93.9 | 3,160,181 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 May 2023 | 39,130 | 0 | - | - | Stock Option (Right to Buy Common Stock) | |
| Richard A. Meier | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 93.93 per share. | 12 May 2023 | 6,137 | 111,357 (0%) | 0% | 93.9 | 576,448 | Common Stock |
| Richard A. Meier | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 12 May 2023 | 8,500 | 117,494 (0%) | 0% | 67.8 | 576,385 | Common Stock |
| Richard A. Meier | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 May 2023 | 8,500 | 0 | - | - | Stock Option (Right to Buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 11 May 2023 | 30,000 | 456,213 (0%) | 0% | 67.8 | 2,034,300 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 95.22 per share. | 11 May 2023 | 5,561 | 426,213 (0%) | 0% | 95.2 | 529,518 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 94.55 per share. | 11 May 2023 | 24,439 | 431,774 (0%) | 0% | 94.5 | 2,310,707 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 May 2023 | 30,000 | 39,130 | - | - | Stock Option (Right to Buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Apr 2023 | 30,000 | 99,130 | - | - | Stock Option (Right to Buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Apr 2023 | 30,000 | 69,130 | - | - | Stock Option (Right to Buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 66.88 per share. | 28 Apr 2023 | 317 | 426,213 (0%) | 0% | 66.9 | 21,201 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 28 Apr 2023 | 30,000 | 456,213 (0%) | 0% | 67.8 | 2,034,300 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 94.22 per share. | 28 Apr 2023 | 13,626 | 442,587 (0%) | 0% | 94.2 | 1,283,842 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 95.49 per share. | 28 Apr 2023 | 14,964 | 427,623 (0%) | 0% | 95.5 | 1,428,912 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 95.90 per share. | 28 Apr 2023 | 1,410 | 426,213 (0%) | 0% | 95.9 | 135,219 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 28 Apr 2023 | 30,000 | 456,213 (0%) | 0% | 67.8 | 2,034,300 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 94.65 per share. | 28 Apr 2023 | 21,453 | 434,760 (0%) | 0% | 94.6 | 2,030,526 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 95.34 per share. | 28 Apr 2023 | 8,547 | 426,213 (0%) | 0% | 95.3 | 814,871 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 66.88 per share. | 28 Apr 2023 | 317 | 80,684 (0%) | 0% | 66.9 | 21,201 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 28 Apr 2023 | 210 | 80,474 (0%) | 0% | 0 | Common Stock | |
| Charles Greg Guyer | EVP, Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 66.88 per share. | 28 Apr 2023 | 239 | 49,703 (0%) | 0% | 66.9 | 15,984 | Common Stock |
| Charles Greg Guyer | EVP, Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 95.45 per share. | 28 Apr 2023 | 4,302 | 45,401 (0%) | 0% | 95.5 | 410,626 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Apr 2023 | 10,000 | 129,130 | - | - | Stock Option (Right to Buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 10 Apr 2023 | 10,000 | 435,896 (0%) | 0% | 67.8 | 678,100 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 99.56 per share. | 10 Apr 2023 | 10,000 | 425,896 (0%) | 0% | 99.6 | 995,600 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Apr 2023 | 10,000 | 139,130 | - | - | Stock Option (Right to Buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 06 Apr 2023 | 10,000 | 435,896 (0%) | 0% | 67.8 | 678,100 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 96.13 per share. | 06 Apr 2023 | 10,000 | 425,896 (0%) | 0% | 96.1 | 961,300 | Common Stock |
| V. Bryan Lawlis | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Apr 2023 | 8,500 | 0 | - | - | Stock Option (Right to Buy Common Stock) | |
| V. Bryan Lawlis | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 03 Apr 2023 | 8,500 | 37,450 (0%) | 0% | 67.8 | 576,385 | Common Stock |
| V. Bryan Lawlis | Director | Sale of securities on an exchange or to another person at price $ 97.09 per share. | 03 Apr 2023 | 8,500 | 28,950 (0%) | 0% | 97.1 | 825,265 | Common Stock |
| Henry J. Fuchs | President, Worldwide R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 87.74 per share. | 15 Mar 2023 | 4,799 | 224,187 (0%) | 0% | 87.7 | 421,064 | Common Stock |
| Henry J. Fuchs | President, Worldwide R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2023 | 16,840 | 228,986 (0%) | 0% | 0 | Common Stock | |
| Henry J. Fuchs | President, Worldwide R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2023 | 38,450 | 38,450 | - | - | Stock Option (Right to buy Common Stock) | |
| Henry J. Fuchs | President, Worldwide R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 93.41 per share. | 15 Mar 2023 | 36,000 | 188,187 (0%) | 0% | 93.4 | 3,362,760 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 87.74 per share. | 15 Mar 2023 | 9,437 | 514,519 (0%) | 0% | 87.7 | 828,002 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 93.41 per share. | 15 Mar 2023 | 88,623 | 425,896 (0%) | 0% | 93.4 | 8,278,274 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2023 | 49,430 | 49,430 | - | - | Stock Option (Right to buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2023 | 36,100 | 523,956 (0%) | 0% | 0 | Common Stock | |
| G. Eric Davis | EVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2023 | 8,900 | 103,349 (0%) | 0% | 0 | Common Stock | |
| G. Eric Davis | EVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2023 | 20,320 | 20,320 | - | - | Stock Option (Right to buy Common Stock) | |
| G. Eric Davis | EVP, Chief Legal Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 93.41 per share. | 15 Mar 2023 | 19,957 | 80,367 (0%) | 0% | 93.4 | 1,864,183 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 87.74 per share. | 15 Mar 2023 | 3,025 | 100,324 (0%) | 0% | 87.7 | 265,414 | Common Stock |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 93.41 per share. | 15 Mar 2023 | 20,510 | 65,486 (0%) | 0% | 93.4 | 1,915,839 | Common Stock |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2023 | 10,110 | 89,967 (0%) | 0% | 0 | Common Stock | |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 87.74 per share. | 15 Mar 2023 | 3,971 | 85,996 (0%) | 0% | 87.7 | 348,416 | Common Stock |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2023 | 23,070 | 23,070 | - | - | Stock Option (Right to buy Common Stock) | |
| Brian Mueller | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 87.74 per share. | 15 Mar 2023 | 2,708 | 59,558 (0%) | 0% | 87.7 | 237,600 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2023 | 9,630 | 62,266 (0%) | 0% | 0 | Common Stock | |
| Brian Mueller | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2023 | 21,970 | 21,970 | - | - | Stock Option (Right to buy Common Stock) | |
| Brian Mueller | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 93.41 per share. | 15 Mar 2023 | 3,973 | 55,585 (0%) | 0% | 93.4 | 371,118 | Common Stock |
| Charles Greg Guyer | EVP, Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2023 | 8,900 | 51,320 (0%) | 0% | 0 | Common Stock | |
| Charles Greg Guyer | EVP, Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 87.74 per share. | 15 Mar 2023 | 1,856 | 49,464 (0%) | 0% | 87.7 | 162,845 | Common Stock |
| Charles Greg Guyer | EVP, Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2023 | 20,320 | 20,320 | - | - | Stock Option (Right to buy Common Stock) | |
| Erin Burkhart | GVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2023 | 3,760 | 14,890 (0%) | 0% | 0 | Common Stock | |
| Erin Burkhart | GVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2023 | 5,720 | 5,720 | - | - | Stock Option (Right to buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2023 | 15,000 | 157,130 | - | - | Stock Option (Right to buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2023 | 8,000 | 149,130 | - | - | Stock Option (Right to buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 10 Mar 2023 | 8,000 | 495,856 (0%) | 0% | 67.8 | 542,480 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 10 Mar 2023 | 15,000 | 502,856 (0%) | 0% | 67.8 | 1,017,150 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 90.45 per share. | 10 Mar 2023 | 8,000 | 487,856 (0%) | 0% | 90.5 | 723,600 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 92.28 per share. | 10 Mar 2023 | 15,000 | 487,856 (0%) | 0% | 92.3 | 1,384,200 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 1,250 | 52,636 (0%) | 0% | 0 | Common Stock | |
| Henry J. Fuchs | President, Worldwide R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 18,220 | 198,754 (0%) | 0% | 0 | Common Stock | |
| Henry J. Fuchs | President, Worldwide R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 36,440 | 180,534 (0%) | 0% | 0 | Common Stock | |
| Henry J. Fuchs | President, Worldwide R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 13,392 | 212,146 (0%) | 0% | 0 | Common Stock | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 44,860 | 454,884 (0%) | 0% | 0 | Common Stock | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 89,700 | 410,024 (0%) | 0% | 0 | Common Stock | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 32,972 | 487,856 (0%) | 0% | 0 | Common Stock | |
| G. Eric Davis | EVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 20,200 | 76,925 (0%) | 0% | 0 | Common Stock | |
| G. Eric Davis | EVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 10,100 | 87,025 (0%) | 0% | 0 | Common Stock | |
| G. Eric Davis | EVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 7,424 | 94,449 (0%) | 0% | 0 | Common Stock | |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 10,380 | 72,228 (0%) | 0% | 0 | Common Stock | |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 7,629 | 79,857 (0%) | 0% | 0 | Common Stock | |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 20,760 | 61,848 (0%) | 0% | 0 | Common Stock | |
| Brian Mueller | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 10,980 | 51,386 (0%) | 0% | 0 | Common Stock | |
| Brian Mueller | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 12,660 | 40,406 (0%) | 0% | 0 | Common Stock | |
| G. Eric Davis | EVP, Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2023 | 1,474 | 0 | - | - | Stock Option (Right to buy Common Stock) | |
| G. Eric Davis | EVP, Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 24 Feb 2023 | 1,474 | 56,725 (0%) | 0% | 67.8 | 99,952 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2023 | 15,000 | 178,130 | - | - | Stock Option (Right to buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 109.15 per share. | 07 Feb 2023 | 6,000 | 320,324 (0%) | 0% | 109.2 | 654,900 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 07 Feb 2023 | 200 | 247,333 (0%) | 0% | 0 | Common Stock | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 110.11 per share. | 07 Feb 2023 | 15,000 | 320,324 (0%) | 0% | 110.1 | 1,651,650 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 07 Feb 2023 | 6,000 | 326,324 (0%) | 0% | 67.8 | 406,860 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2023 | 6,000 | 172,130 | - | - | Stock Option (Right to buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 07 Feb 2023 | 15,000 | 335,324 (0%) | 0% | 67.8 | 1,017,150 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 07 Feb 2023 | 100 | 100 (0%) | 0% | 0 | Common Stock | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 07 Feb 2023 | 100 | 100 (0%) | 0% | 0 | Common Stock | |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 115.65 per share. | 25 Jan 2023 | 44,825 | 45,263 (0%) | 0% | 115.7 | 5,184,191 | Common Stock |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jan 2023 | 46,800 | 0 | - | - | Stock Option (Right to buy Common Stock) | |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jan 2023 | 2,200 | 0 | - | - | Stock Option (Right to buy Common Stock) | |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 116.15 per share. | 25 Jan 2023 | 4,175 | 41,088 (0%) | 0% | 116.2 | 484,943 | Common Stock |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 25 Jan 2023 | 49,000 | 90,088 (0%) | 0% | 67.8 | 3,322,690 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 13 Jan 2023 | 10,000 | 330,424 (0%) | 0% | 67.8 | 678,100 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Jan 2023 | 10,000 | 193,130 | - | - | Stock Option (Right to buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Jan 2023 | 10,000 | 203,130 | - | - | Stock Option (Right to buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 111.55 per share. | 13 Jan 2023 | 10,000 | 320,424 (0%) | 0% | 111.6 | 1,115,500 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 13 Jan 2023 | 10,000 | 330,424 (0%) | 0% | 67.8 | 678,100 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 112.25 per share. | 13 Jan 2023 | 10,000 | 320,424 (0%) | 0% | 112.3 | 1,122,500 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.10 per share. | 13 Jan 2023 | 2,500 | 30,246 (0%) | 0% | 63.1 | 157,750 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Jan 2023 | 2,500 | 5,000 | - | - | Stock Option (Right to buy Common Stock) | |
| Brian Mueller | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 114.50 per share. | 13 Jan 2023 | 2,500 | 27,746 (0%) | 0% | 114.5 | 286,250 | Common Stock |
| Henry J. Fuchs | President, Worldwide R&D | Grant, award, or other acquisition of securities at price $ 62.41 per share. | 31 Dec 2022 | 341 | 144,094 (0%) | 0% | 62.4 | 21,281 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2022 | 100 | 320,324 (0%) | 0% | 0 | Common Stock | |
| Charles Greg Guyer | EVP, Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 62.41 per share. | 31 Dec 2022 | 252 | 42,420 (0%) | 0% | 62.4 | 15,727 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 106.89 per share. | 13 Dec 2022 | 1,000 | 320,424 (0%) | 0% | 106.9 | 106,890 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 107.50 per share. | 13 Dec 2022 | 2,500 | 27,746 (0%) | 0% | 107.5 | 268,750 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.10 per share. | 13 Dec 2022 | 2,500 | 30,246 (0%) | 0% | 63.1 | 157,750 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2022 | 2,500 | 7,500 | - | - | Stock Option (Right to buy Common Stock) | |
| Brian Mueller | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 02 Dec 2022 | 2,139 | 29,885 (0%) | 0% | 67.8 | 145,046 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Dec 2022 | 3,761 | 0 | - | - | Stock Option (Right to buy Common Stock) | |
| Brian Mueller | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Dec 2022 | 2,139 | 0 | - | - | Stock Option (Right to buy Common Stock) | |
| Brian Mueller | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 104.50 per share. | 02 Dec 2022 | 3,761 | 27,746 (0%) | 0% | 104.5 | 393,025 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 02 Dec 2022 | 3,761 | 31,507 (0%) | 0% | 67.8 | 255,033 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 104.50 per share. | 02 Dec 2022 | 2,139 | 27,746 (0%) | 0% | 104.5 | 223,526 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 104.50 per share. | 02 Dec 2022 | 1,101 | 27,746 (0%) | 0% | 104.5 | 115,055 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 95.09 per share. | 23 Nov 2022 | 934 | 29,792 (0%) | 0% | 95.1 | 88,814 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Nov 2022 | 3,500 | 3,761 | - | - | Stock Option (Right to buy Common Stock) | |
| Brian Mueller | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 99.50 per share. | 23 Nov 2022 | 3,500 | 28,847 (0%) | 0% | 99.5 | 348,250 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 23 Nov 2022 | 3,500 | 32,347 (0%) | 0% | 67.8 | 237,335 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 99.50 per share. | 23 Nov 2022 | 945 | 28,847 (0%) | 0% | 99.5 | 94,028 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 103.98 per share. | 02 Nov 2022 | 260 | 321,593 (0%) | 0% | 104.0 | 27,035 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 103.97 per share. | 02 Nov 2022 | 471 | 322,453 (0%) | 0% | 104.0 | 48,970 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | 02 Nov 2022 | 100 | 322,924 (0%) | 0% | 86.1 | 8,612 | Common Stock | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 103.97 per share. | 02 Nov 2022 | 600 | 321,853 (0%) | 0% | 104.0 | 62,383 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 104.06 per share. | 02 Nov 2022 | 69 | 321,424 (0%) | 0% | 104.1 | 7,180 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 104.00 per share. | 02 Nov 2022 | 100 | 321,493 (0%) | 0% | 104 | 10,400 | Common Stock |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 86.12 per share. | 02 Nov 2022 | 3,000 | 41,088 (0%) | 0% | 86.1 | 258,360 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 86.55 per share. | 31 Oct 2022 | 1,500 | 322,824 (0%) | 0% | 86.6 | 129,825 | Common Stock |
| Mark J. Alles | Director | Purchase of securities on an exchange or from another person at price $ 86.75 per share. | 31 Oct 2022 | 3,625 | 10,905 (0%) | 0% | 86.8 | 314,469 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 89.89 per share. | 14 Oct 2022 | 4,000 | 324,324 (0%) | 0% | 89.9 | 359,560 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 94.75 per share. | 12 Aug 2022 | 4,000 | 331,324 (0%) | 0% | 94.8 | 379,000 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 95.21 per share. | 12 Aug 2022 | 3,000 | 328,324 (0%) | 0% | 95.2 | 285,630 | Common Stock |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 95.62 per share. | 11 Aug 2022 | 3,000 | 44,088 (0%) | 0% | 95.6 | 286,860 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Aug 2022 | 47,526 | 0 | - | - | Stock Option (Right to buy Common Stock) | |
| G. Eric Davis | EVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 95.93 per share. | 09 Aug 2022 | 47,526 | 55,251 (0%) | 0% | 95.9 | 4,559,169 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 09 Aug 2022 | 47,526 | 102,777 (0%) | 0% | 67.8 | 3,222,738 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 96.34 per share. | 09 Aug 2022 | 3,690 | 55,251 (0%) | 0% | 96.3 | 355,495 | Common Stock |
| Charles Greg Guyer | EVP, Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 96.56 per share. | 08 Aug 2022 | 6,205 | 42,168 (0%) | 0% | 96.6 | 599,155 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 94.50 per share. | 05 Aug 2022 | 3,500 | 30,726 (0%) | 0% | 94.5 | 330,750 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Aug 2022 | 3,500 | 7,261 | - | - | Stock Option (Right to buy Common Stock) | |
| Brian Mueller | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.81 per share. | 05 Aug 2022 | 3,500 | 34,226 (0%) | 0% | 67.8 | 237,335 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 90.00 per share. | 08 Jul 2022 | 7,398 | 58,941 (0%) | 0% | 90 | 665,820 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 89.50 per share. | 08 Jul 2022 | 7,337 | 30,726 (0%) | 0% | 89.5 | 656,662 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 83.92 per share. | 29 Jun 2022 | 576 | 38,063 (0%) | 0% | 83.9 | 48,338 | Common Stock |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 77.49 per share. | 03 Jun 2022 | 7,021 | 47,088 (0%) | 0% | 77.5 | 544,057 | Common Stock |
| Elaine J. Heron | Director | 24 May 2022 | 4,980 | 85,568 (0%) | 0% | 0 | Common Stock | ||
| Richard A. Meier | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2022 | 4,980 | 108,994 (0%) | 0% | 0 | Common Stock | |
| Willard H. Dere | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2022 | 4,980 | 23,390 (0%) | 0% | 0 | Common Stock | |
| David E.I. Pyott | Director | 24 May 2022 | 4,980 | 40,840 (0%) | 0% | 0 | Common Stock | ||
| V. Bryan Lawlis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2022 | 4,980 | 28,950 (0%) | 0% | 0 | Common Stock | |
| Robert J. Hombach | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2022 | 4,980 | 26,310 (0%) | 0% | 0 | Common Stock | |
| Mark J. Alles | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2022 | 4,980 | 7,280 (0%) | 0% | 0 | Common Stock | |
| Dennis J. Slamon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2022 | 4,980 | 26,619 (0%) | 0% | 0 | Common Stock | |
| Maykin Ho | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2022 | 4,980 | 12,450 (0%) | 0% | 0 | Common Stock | |
| Elizabeth McKee Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2022 | 4,980 | 18,890 (0%) | 0% | 0 | Common Stock | |
| Erin Burkhart | GVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2022 | 17,490 | 17,490 | - | - | Stock Option (Right to buy Common Stock) | |
| Erin Burkhart | GVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2022 | 11,130 | 11,130 (0%) | 0% | 0 | Common Stock | |
| Richard A. Meier | Director | Sale of securities on an exchange or to another person at price $ 82.09 per share. | 02 May 2022 | 3,860 | 104,032 (0%) | 0% | 82.1 | 316,867 | Common Stock |
| Richard A. Meier | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 May 2022 | 8,500 | 0 | - | - | Stock Option (Right to buy Common Stock) | |
| Richard A. Meier | Director | Sale of securities on an exchange or to another person at price $ 82.11 per share. | 02 May 2022 | 18 | 104,014 (0%) | 0% | 82.1 | 1,478 | Common Stock |
| Richard A. Meier | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.46 per share. | 02 May 2022 | 8,500 | 107,892 (0%) | 0% | 37.5 | 318,410 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 81.00 per share. | 29 Apr 2022 | 20,000 | 335,324 (0%) | 0% | 81 | 1,620,000 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.46 per share. | 29 Apr 2022 | 20,000 | 355,324 (0%) | 0% | 37.5 | 749,200 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 84.14 per share. | 29 Apr 2022 | 10,000 | 335,324 (0%) | 0% | 84.1 | 841,400 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.46 per share. | 29 Apr 2022 | 10,000 | 345,324 (0%) | 0% | 37.5 | 374,600 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 62.41 per share. | 29 Apr 2022 | 341 | 335,324 (0%) | 0% | 62.4 | 21,281 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Apr 2022 | 20,000 | 0 | - | - | Stock Option (Right to buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Apr 2022 | 10,000 | 20,000 | - | - | Stock Option (Right to buy Common Stock) | |
| G. Eric Davis | EVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 80.38 per share. | 29 Apr 2022 | 15,347 | 66,339 (0%) | 0% | 80.4 | 1,233,592 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 62.41 per share. | 29 Apr 2022 | 341 | 66,339 (0%) | 0% | 62.4 | 21,281 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.46 per share. | 29 Apr 2022 | 15,347 | 81,686 (0%) | 0% | 37.5 | 574,899 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Apr 2022 | 15,347 | 0 | - | - | Stock Option (Right to buy Common Stock) | |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 78.94 per share. | 29 Apr 2022 | 1,308 | 54,109 (0%) | 0% | 78.9 | 103,254 | Common Stock |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 62.41 per share. | 29 Apr 2022 | 340 | 55,417 (0%) | 0% | 62.4 | 21,218 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 81.95 per share. | 28 Apr 2022 | 5,000 | 334,983 (0%) | 0% | 82.0 | 409,750 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.46 per share. | 28 Apr 2022 | 5,000 | 339,983 (0%) | 0% | 37.5 | 187,300 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 83.79 per share. | 28 Apr 2022 | 20,000 | 334,983 (0%) | 0% | 83.8 | 1,675,800 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.46 per share. | 28 Apr 2022 | 20,000 | 354,983 (0%) | 0% | 37.5 | 749,200 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Apr 2022 | 5,000 | 30,000 | - | - | Stock Option (Right to buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Apr 2022 | 20,000 | 35,000 | - | - | Stock Option (Right to buy Common Stock) | |
| G. Eric Davis | EVP, Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.46 per share. | 25 Apr 2022 | 2,669 | 65,998 (0%) | 0% | 37.5 | 99,981 | Common Stock |
| G. Eric Davis | EVP, Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Apr 2022 | 2,669 | 0 | - | - | Stock Option (Right to buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 81.91 per share. | 18 Apr 2022 | 20,000 | 334,983 (0%) | 0% | 81.9 | 1,638,200 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.46 per share. | 18 Apr 2022 | 20,000 | 354,983 (0%) | 0% | 37.5 | 749,200 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Apr 2022 | 20,000 | 55,000 | - | - | Stock Option (Right to buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 83.66 per share. | 14 Apr 2022 | 10,000 | 334,983 (0%) | 0% | 83.7 | 836,600 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.46 per share. | 14 Apr 2022 | 10,000 | 344,983 (0%) | 0% | 37.5 | 374,600 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Apr 2022 | 10,000 | 75,000 | - | - | Stock Option (Right to buy Common Stock) | |
| V. Bryan Lawlis | Director | Sale of securities on an exchange or to another person at price $ 83.66 per share. | 14 Apr 2022 | 4,250 | 23,970 (0%) | 0% | 83.7 | 355,555 | Common Stock |
| V. Bryan Lawlis | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.46 per share. | 14 Apr 2022 | 4,250 | 28,220 (0%) | 0% | 37.5 | 159,205 | Common Stock |
| V. Bryan Lawlis | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Apr 2022 | 4,250 | 0 | - | - | Stock Option (Right to buy Common Stock) | |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 82.47 per share. | 13 Apr 2022 | 1,180 | 55,077 (0%) | 0% | 82.5 | 97,315 | Common Stock |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 79.56 per share. | 29 Mar 2022 | 1,381 | 56,257 (0%) | 0% | 79.6 | 109,872 | Common Stock |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 79.43 per share. | 29 Mar 2022 | 1,618 | 57,638 (0%) | 0% | 79.4 | 128,518 | Common Stock |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 81.00 per share. | 22 Mar 2022 | 2,073 | 65,385 (0%) | 0% | 81 | 167,913 | Common Stock |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 81.78 per share. | 22 Mar 2022 | 6,129 | 59,256 (0%) | 0% | 81.8 | 501,230 | Common Stock |
| G. Eric Davis | EVP, General Counsel | Sale of securities on an exchange or to another person at price $ 81.29 per share. | 21 Mar 2022 | 6,129 | 63,329 (0%) | 0% | 81.3 | 498,226 | Common Stock |
| Henry J. Fuchs | President, Worldwide R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 78.27 per share. | 15 Mar 2022 | 12,101 | 146,012 (0%) | 0% | 78.3 | 947,145 | Common Stock |
| Henry J. Fuchs | President, Worldwide R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2022 | 35,830 | 35,830 | - | - | Stock Option (Right to buy Common Stock) | |
| Henry J. Fuchs | President, Worldwide R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 80.72 per share. | 15 Mar 2022 | 2,259 | 143,753 (0%) | 0% | 80.7 | 182,346 | Common Stock |
| Henry J. Fuchs | President, Worldwide R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2022 | 38,790 | 158,113 (0%) | 0% | 0 | Common Stock | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 78.27 per share. | 15 Mar 2022 | 38,306 | 340,543 (0%) | 0% | 78.3 | 2,998,211 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2022 | 58,040 | 58,040 | - | - | Stock Option (Right to buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 80.72 per share. | 15 Mar 2022 | 5,560 | 334,983 (0%) | 0% | 80.7 | 448,803 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2022 | 40,280 | 378,849 (0%) | 0% | 0 | Common Stock | |
| G. Eric Davis | EVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 80.72 per share. | 15 Mar 2022 | 1,252 | 69,458 (0%) | 0% | 80.7 | 101,061 | Common Stock |
| G. Eric Davis | EVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 78.27 per share. | 15 Mar 2022 | 8,290 | 70,710 (0%) | 0% | 78.3 | 648,858 | Common Stock |
| G. Eric Davis | EVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2022 | 11,040 | 79,000 (0%) | 0% | 0 | Common Stock | |
| G. Eric Davis | EVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2022 | 26,520 | 26,520 | - | - | Stock Option (Right to buy Common Stock) | |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2022 | 11,940 | 77,163 (0%) | 0% | 0 | Common Stock | |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 80.72 per share. | 15 Mar 2022 | 1,287 | 67,458 (0%) | 0% | 80.7 | 103,887 | Common Stock |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 78.27 per share. | 15 Mar 2022 | 8,418 | 68,745 (0%) | 0% | 78.3 | 658,877 | Common Stock |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2022 | 28,670 | 28,670 | - | - | Stock Option (Right to buy Common Stock) | |
| Brian Mueller | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 78.27 per share. | 15 Mar 2022 | 1,868 | 38,881 (0%) | 0% | 78.3 | 146,208 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 80.72 per share. | 15 Mar 2022 | 582 | 38,299 (0%) | 0% | 80.7 | 46,979 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2022 | 26,520 | 26,520 | - | - | Stock Option (Right to buy Common Stock) | |
| Brian Mueller | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2022 | 11,040 | 40,749 (0%) | 0% | 0 | Common Stock | |
| Charles Greg Guyer | EVP, Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2022 | 26,520 | 26,520 | - | - | Stock Option (Right to buy Common Stock) | |
| Charles Greg Guyer | EVP, Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 78.27 per share. | 15 Mar 2022 | 920 | 52,056 (0%) | 0% | 78.3 | 72,008 | Common Stock |
| Charles Greg Guyer | EVP, Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2022 | 11,040 | 52,976 (0%) | 0% | 0 | Common Stock | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.46 per share. | 10 Mar 2022 | 15,000 | 353,569 (0%) | 0% | 37.5 | 561,900 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2022 | 15,000 | 85,000 | - | - | Stock Option (Right to buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2022 | 15,000 | 100,000 | - | - | Stock Option (Right to buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 77.81 per share. | 10 Mar 2022 | 15,000 | 338,569 (0%) | 0% | 77.8 | 1,167,150 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.46 per share. | 10 Mar 2022 | 15,000 | 353,569 (0%) | 0% | 37.5 | 561,900 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 77.57 per share. | 10 Mar 2022 | 15,000 | 338,569 (0%) | 0% | 77.6 | 1,163,550 | Common Stock |
| Henry J. Fuchs | President, Worldwide R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Mar 2022 | 12,840 | 119,323 (0%) | 0% | 0 | Common Stock | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Mar 2022 | 34,780 | 338,569 (0%) | 0% | 0 | Common Stock | |
| G. Eric Davis | EVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Mar 2022 | 9,370 | 67,960 (0%) | 0% | 0 | Common Stock | |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Mar 2022 | 9,370 | 65,223 (0%) | 0% | 0 | Common Stock | |
| Dennis J. Slamon | Director | Sale of securities on an exchange or to another person at price $ 78.33 per share. | 28 Feb 2022 | 45 | 22,175 (0%) | 0% | 78.3 | 3,525 | Common Stock |
| Dennis J. Slamon | Director | Sale of securities on an exchange or to another person at price $ 78.37 per share. | 28 Feb 2022 | 100 | 21,639 (0%) | 0% | 78.4 | 7,837 | Common Stock |
| Dennis J. Slamon | Director | Sale of securities on an exchange or to another person at price $ 78.36 per share. | 28 Feb 2022 | 122 | 21,739 (0%) | 0% | 78.4 | 9,560 | Common Stock |
| Dennis J. Slamon | Director | Sale of securities on an exchange or to another person at price $ 78.35 per share. | 28 Feb 2022 | 100 | 21,861 (0%) | 0% | 78.4 | 7,835 | Common Stock |
| Dennis J. Slamon | Director | Sale of securities on an exchange or to another person at price $ 78.35 per share. | 28 Feb 2022 | 214 | 21,961 (0%) | 0% | 78.4 | 16,767 | Common Stock |
| Dennis J. Slamon | Director | Sale of securities on an exchange or to another person at price $ 78.33 per share. | 28 Feb 2022 | 5,815 | 22,220 (0%) | 0% | 78.3 | 455,489 | Common Stock |
| Elaine J. Heron | Director | 25 Feb 2022 | 8,500 | 0 | - | - | Stock Option (Right to buy Common Stock) | ||
| Elaine J. Heron | Director | 25 Feb 2022 | 8,500 | 80,588 (0%) | 0% | 37.5 | 318,410 | Common Stock | |
| Brian Mueller | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 87.77 per share. | 03 Feb 2022 | 1,072 | 29,709 (0%) | 0% | 87.8 | 94,089 | Common Stock |
| V. Bryan Lawlis | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.46 per share. | 14 Jan 2022 | 4,250 | 28,220 (0%) | 0% | 37.5 | 159,205 | Common Stock |
| V. Bryan Lawlis | Director | Sale of securities on an exchange or to another person at price $ 87.61 per share. | 14 Jan 2022 | 4,250 | 23,970 (0%) | 0% | 87.6 | 372,343 | Common Stock |
| V. Bryan Lawlis | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jan 2022 | 4,250 | 4,250 | - | - | Stock Option (Right to buy Common Stock) | |
| Mark J. Alles | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2022 | 2,300 | 2,300 (0%) | 0% | 0 | Common Stock | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Oct 2021 | 1,000 | 137,000 | - | - | Stock Option (Right to buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.46 per share. | 20 Oct 2021 | 1,000 | 305,839 (0%) | 0% | 37.5 | 37,460 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | 09 Sep 2021 | 50 | 305,889 (0%) | 0% | 78.8 | 3,939 | Common Stock | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 87.22 per share. | 09 Sep 2021 | 1,500 | 304,389 (0%) | 0% | 87.2 | 130,832 | Common Stock |
| G. Eric Davis | EVP, General Counsel | Sale of securities on an exchange or to another person at price $ 76.69 per share. | 02 Aug 2021 | 5,518 | 58,590 (0%) | 0% | 76.7 | 423,175 | Common Stock |
| Brian Mueller | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 83.46 per share. | 29 Jun 2021 | 576 | 30,781 (0%) | 0% | 83.5 | 48,073 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.46 per share. | 21 Jun 2021 | 1,000 | 304,839 (0%) | 0% | 37.5 | 37,460 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jun 2021 | 1,000 | 138,000 | - | - | Stock Option (Right to buy Common Stock) | |
| Elaine J. Heron | Director | 25 May 2021 | 5,120 | 72,088 (0%) | 0% | 0 | Common Stock | ||
| Richard A. Meier | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 5,120 | 99,392 (0%) | 0% | 0 | Common Stock | |
| Willard H. Dere | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 5,120 | 18,410 (0%) | 0% | 0 | Common Stock | |
| David E.I. Pyott | Director | 25 May 2021 | 5,120 | 35,860 (0%) | 0% | 0 | Common Stock | ||
| V. Bryan Lawlis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 5,120 | 23,970 (0%) | 0% | 0 | Common Stock | |
| Robert J. Hombach | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 5,120 | 21,330 (0%) | 0% | 0 | Common Stock | |
| Dennis J. Slamon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 5,120 | 28,035 (0%) | 0% | 0 | Common Stock | |
| Maykin Ho | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 5,120 | 7,470 (0%) | 0% | 0 | Common Stock | |
| Elizabeth McKee Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 5,120 | 13,910 (0%) | 0% | 0 | Common Stock | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 77.29 per share. | 10 May 2021 | 8,513 | 303,839 (0%) | 0% | 77.3 | 657,970 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.49 per share. | 10 May 2021 | 8,513 | 312,352 (0%) | 0% | 26.5 | 225,509 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 May 2021 | 8,513 | 0 | - | - | Stock Option (Right to buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 62.41 per share. | 30 Apr 2021 | 341 | 303,839 (0%) | 0% | 62.4 | 21,281 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2021 | 25,000 | 8,513 | - | - | Stock Option (Right to buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2021 | 25,000 | 33,513 | - | - | Stock Option (Right to buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 79.39 per share. | 30 Apr 2021 | 3,329 | 303,839 (0%) | 0% | 79.4 | 264,303 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 78.77 per share. | 30 Apr 2021 | 6,115 | 307,168 (0%) | 0% | 78.8 | 481,672 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 77.60 per share. | 30 Apr 2021 | 15,556 | 313,283 (0%) | 0% | 77.6 | 1,207,146 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.49 per share. | 30 Apr 2021 | 25,000 | 328,839 (0%) | 0% | 26.5 | 662,250 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 78.69 per share. | 30 Apr 2021 | 10,175 | 303,839 (0%) | 0% | 78.7 | 800,671 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 78.01 per share. | 30 Apr 2021 | 14,825 | 314,014 (0%) | 0% | 78.0 | 1,156,528 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.49 per share. | 30 Apr 2021 | 25,000 | 328,839 (0%) | 0% | 26.5 | 662,250 | Common Stock |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2021 | 1,000 | 139,000 | - | - | Stock Option (Right to buy Common Stock) | |
| Jean-Jacques Bienaime | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.46 per share. | 30 Apr 2021 | 1,000 | 303,498 (0%) | 0% | 37.5 | 37,460 | Common Stock |
| G. Eric Davis | EVP, General Counsel | Grant, award, or other acquisition of securities at price $ 62.41 per share. | 30 Apr 2021 | 341 | 68,781 (0%) | 0% | 62.4 | 21,281 | Common Stock |
| G. Eric Davis | EVP, General Counsel | Sale of securities on an exchange or to another person at price $ 78.30 per share. | 30 Apr 2021 | 2,584 | 66,197 (0%) | 0% | 78.3 | 202,327 | Common Stock |
| G. Eric Davis | EVP, General Counsel | Sale of securities on an exchange or to another person at price $ 78.30 per share. | 30 Apr 2021 | 2,089 | 64,108 (0%) | 0% | 78.3 | 163,569 | Common Stock |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 62.41 per share. | 30 Apr 2021 | 342 | 58,592 (0%) | 0% | 62.4 | 21,343 | Common Stock |
| Jeffrey R. Ajer | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 73.60 per share. | 30 Apr 2021 | 2,739 | 55,853 (0%) | 0% | 73.6 | 201,590 | Common Stock |