XNAS 09 Oct, 2026 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Mr. Kabir Nath | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.25 per share. | 03 Aug 2026 | 5,962 | 361,028 | - | 11.3 | 67,073 | Ordinary Shares |
| Mr. Gino Santini | Director | 27 May 2026 | 30,158 | 30,158 | - | - | Share Option (Right to Buy) | ||
| Dr. Jeffrey M. Jonas,M.D. | Director | 27 May 2026 | 21,110 | 21,110 | - | - | Share Option (Right to Buy) | ||
| Dr. Wayne Joseph Riley, M.B.A.,M.D.,M.P.H. | Director | 27 May 2026 | 21,110 | 21,110 | - | - | Share Option (Right to Buy) | ||
| Mr. Justin David Gover | Director | 27 May 2026 | 21,110 | 21,110 | - | - | Share Option (Right to Buy) | ||
| Mr. David York Norton | Director | 27 May 2026 | 21,110 | 21,110 | - | - | Share Option (Right to Buy) | ||
| Ms. Kathleen Tregoning, M.A. | Director | 27 May 2026 | 41,119 | 41,119 | - | - | Share Option (Right to Buy) | ||
| Ms. Daphne Karydas, M.B.A. | Director | 27 May 2026 | 21,110 | 21,110 | - | - | Share Option (Right to Buy) | ||
| Dr. Robert McQuade, PhD | Director | 27 May 2026 | 21,110 | 21,110 | - | - | Share Option (Right to Buy) | ||
| Mr. Kabir Nath | Director, Chief Executive Officer | 26 Mar 2026 | 367,815 | 367,815 | - | - | Share Option (Right to Buy) | ||
| Mr. Kabir Nath | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Mar 2026 | 175,000 | 366,990 | - | 0 | Ordinary Shares | |
| Ms. Teri Loxam, M.B.A. | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Mar 2026 | 75,000 | 152,002 | - | 0 | Ordinary Shares | |
| Ms. Teri Loxam, M.B.A. | Chief Financial Officer | 26 Mar 2026 | 157,635 | 157,635 | - | - | Share Option (Right to Buy) | ||
| Mr. Guy Goodwin | Chief Medical Officer | 26 Mar 2026 | 115,600 | 115,600 | - | - | Share Option (Right to Buy) | ||
| Mr. Guy Goodwin | Chief Medical Officer | 26 Mar 2026 | 55,000 | 55,000 | - | - | Share Option (Right to Buy) | ||
| Mr. Kabir Nath | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.89 per share. | 11 Mar 2026 | 13,131 | 191,990 | - | 6.9 | 90,473 | Ordinary Shares |
| Ms. Teri Loxam, M.B.A. | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.89 per share. | 11 Mar 2026 | 1,781 | 77,002 | - | 6.9 | 12,271 | Ordinary Shares |
| Ms. Teri Loxam, M.B.A. | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.02 per share. | 02 Mar 2026 | 4,467 | 78,783 | - | 7.0 | 31,358 | Ordinary Shares |
| Mr. Kabir Nath | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.61 per share. | 02 Feb 2026 | 16,181 | 205,121 | - | 6.6 | 106,956 | Ordinary Shares |
| Dr. Jeffrey M. Jonas,M.D. | Director | 29 Oct 2025 | 52,000 | 52,000 | - | - | Share Option (Right to Buy) | ||
| Mr. Kabir Nath | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.34 per share. | 01 Aug 2025 | 6,366 | 221,302 | - | 4.3 | 27,628 | Ordinary Shares |
| Mr. Justin David Gover | Director | 29 Jul 2025 | 52,000 | 52,000 | - | - | Share Option (Right to Buy) | ||
| Mr. Gino Santini | Director | 12 Jun 2025 | 39,000 | 39,000 | - | - | Share Option (Right to Buy) | ||
| Dr. Wayne Joseph Riley, M.B.A.,M.D.,M.P.H. | Director | 12 Jun 2025 | 26,000 | 26,000 | - | - | Share Option (Right to Buy) | ||
| Mr. David York Norton | Director | 12 Jun 2025 | 26,000 | 26,000 | - | - | Share Option (Right to Buy) | ||
| Dr. Annalisa Mary Jenkins, F.R.C.P.,M.B.B.S. | Director | 12 Jun 2025 | 26,000 | 26,000 | - | - | Share Option (Right to Buy) | ||
| Ms. Daphne Karydas, M.B.A. | Director | 12 Jun 2025 | 26,000 | 26,000 | - | - | Share Option (Right to Buy) | ||
| Dr. Thomas Lonngren, PhD | Director | 12 Jun 2025 | 26,000 | 26,000 | - | - | Share Option (Right to Buy) | ||
| Dr. Robert McQuade, PhD | Director | 12 Jun 2025 | 26,000 | 26,000 | - | - | Share Option (Right to Buy) | ||
| Mr. Kabir Nath | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Mar 2025 | 92,000 | 227,668 | - | 0 | Ordinary Shares | |
| Mr. Kabir Nath | Director, Chief Executive Officer | 11 Mar 2025 | 275,000 | 275,000 | - | - | Share Option (Right to Buy) | ||
| Ms. Teri Loxam, M.B.A. | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Mar 2025 | 25,000 | 83,250 | - | 0 | Ordinary Shares | |
| Ms. Teri Loxam, M.B.A. | Chief Financial Officer | 11 Mar 2025 | 76,000 | 76,000 | - | - | Share Option (Right to Buy) | ||
| Mr. Guy Goodwin | Chief Medical Officer | 11 Mar 2025 | 32,000 | 32,000 | - | - | Share Option (Right to Buy) | ||
| Mr. Guy Goodwin | Chief Medical Officer | 11 Mar 2025 | 63,000 | 63,000 | - | - | Share Option (Right to Buy) | ||
| Ms. Teri Loxam, M.B.A. | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.67 per share. | 03 Mar 2025 | 4,468 | 58,250 | - | 3.7 | 16,398 | Ordinary Shares |
| Mr. Kabir Nath | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.31 per share. | 03 Feb 2025 | 15,516 | 135,668 | - | 4.3 | 66,874 | Ordinary Shares |
| Mr. George Goldsmith | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 24 Oct 2024 | 776,565 | 3,152,848 | - | - | Ordinary Shares | |
| Mr. George Goldsmith | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 24 Oct 2024 | 776,565 | 3,155,122 | - | - | Ordinary Shares | |
| Dr. Ekaterina Malievskaia, M.D. | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 24 Oct 2024 | 776,565 | 3,155,122 | - | - | Ordinary Shares | |
| Dr. Ekaterina Malievskaia, M.D. | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 24 Oct 2024 | 776,565 | 3,152,848 | - | - | Ordinary Shares | |
| Mr. Gino Santini | Director | 03 Sep 2024 | 52,000 | 52,000 | - | - | Share Option (Right to Buy) | ||
| Mr. Kabir Nath | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.88 per share. | 01 Aug 2024 | 7,064 | 151,184 | - | 6.9 | 48,600 | Ordinary Shares |
| Dr. Annalisa Mary Jenkins, F.R.C.P.,M.B.B.S. | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.88 per share. | 01 Aug 2024 | 161 | 19,480 | - | 6.9 | 1,108 | Ordinary Shares |
| Mr. George Goldsmith | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 7.89 per share. | 20 May 2024 | 6,703 | 3,940,587 | - | 7.9 | 52,900 | Ordinary Shares |
| Mr. George Goldsmith | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 7.89 per share. | 20 May 2024 | 6,704 | 3,938,313 | - | 7.9 | 52,908 | Ordinary Shares |
| Mr. George Goldsmith | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 7.91 per share. | 20 May 2024 | 8,900 | 3,931,687 | - | 7.9 | 70,379 | Ordinary Shares |
| Mr. George Goldsmith | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 7.91 per share. | 20 May 2024 | 8,900 | 3,929,413 | - | 7.9 | 70,379 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 7.89 per share. | 20 May 2024 | 6,704 | 3,938,313 | - | 7.9 | 52,908 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 7.91 per share. | 20 May 2024 | 8,900 | 3,931,687 | - | 7.9 | 70,379 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 7.91 per share. | 20 May 2024 | 8,900 | 3,929,413 | - | 7.9 | 70,379 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 7.89 per share. | 20 May 2024 | 6,703 | 3,940,587 | - | 7.9 | 52,900 | Ordinary Shares |
| Dr. Wayne Joseph Riley, M.B.A.,M.D.,M.P.H. | Director | 09 May 2024 | 26,000 | 26,000 | - | - | Share Option (Right to Buy) | ||
| Mr. David York Norton | Director | 09 May 2024 | 39,000 | 39,000 | - | - | Share Option (Right to Buy) | ||
| Dr. Annalisa Mary Jenkins, F.R.C.P.,M.B.B.S. | Director | 09 May 2024 | 26,000 | 26,000 | - | - | Share Option (Right to Buy) | ||
| Ms. Daphne Karydas, M.B.A. | Director | 09 May 2024 | 26,000 | 26,000 | - | - | Share Option (Right to Buy) | ||
| Dr. Thomas Lonngren, PhD | Director | 09 May 2024 | 26,000 | 26,000 | - | - | Share Option (Right to Buy) | ||
| Mr. Robert McQuade | Director | 09 May 2024 | 26,000 | 26,000 | - | - | Share Option (Right to Buy) | ||
| Mr. George Goldsmith | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.29 per share. | 02 May 2024 | 9,621 | 3,966,052 | - | 8.3 | 79,760 | Ordinary Shares |
| Mr. George Goldsmith | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.82 per share. | 02 May 2024 | 18,761 | 3,945,017 | - | 8.8 | 165,448 | Ordinary Shares |
| Mr. George Goldsmith | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.82 per share. | 02 May 2024 | 18,762 | 3,947,290 | - | 8.8 | 165,456 | Ordinary Shares |
| Mr. George Goldsmith | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.29 per share. | 02 May 2024 | 9,622 | 3,963,778 | - | 8.3 | 79,768 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.29 per share. | 02 May 2024 | 9,622 | 3,963,778 | - | 8.3 | 79,768 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.82 per share. | 02 May 2024 | 18,762 | 3,947,290 | - | 8.8 | 165,456 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.82 per share. | 02 May 2024 | 18,761 | 3,945,017 | - | 8.8 | 165,448 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.29 per share. | 02 May 2024 | 9,621 | 3,966,052 | - | 8.3 | 79,760 | Ordinary Shares |
| Dr. Annalisa Mary Jenkins, F.R.C.P.,M.B.B.S. | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.48 per share. | 01 May 2024 | 211 | 19,641 | - | 8.5 | 1,789 | Ordinary Shares |
| Mr. George Goldsmith | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.53 per share. | 16 Apr 2024 | 23,881 | 3,986,523 | - | 8.5 | 203,679 | Ordinary Shares |
| Mr. George Goldsmith | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.78 per share. | 16 Apr 2024 | 10,850 | 3,973,400 | - | 8.8 | 95,307 | Ordinary Shares |
| Mr. George Goldsmith | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.78 per share. | 16 Apr 2024 | 10,850 | 3,975,673 | - | 8.8 | 95,307 | Ordinary Shares |
| Mr. George Goldsmith | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.53 per share. | 16 Apr 2024 | 23,880 | 3,984,250 | - | 8.5 | 203,670 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.53 per share. | 16 Apr 2024 | 23,880 | 3,984,250 | - | 8.5 | 203,670 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.78 per share. | 16 Apr 2024 | 10,850 | 3,975,673 | - | 8.8 | 95,307 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.78 per share. | 16 Apr 2024 | 10,850 | 3,973,400 | - | 8.8 | 95,307 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.53 per share. | 16 Apr 2024 | 23,881 | 3,986,523 | - | 8.5 | 203,679 | Ordinary Shares |
| Mr. George Goldsmith | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.96 per share. | 01 Apr 2024 | 25,750 | 4,008,130 | - | 9.0 | 230,666 | Ordinary Shares |
| Mr. George Goldsmith | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.96 per share. | 01 Apr 2024 | 25,750 | 4,010,404 | - | 9.0 | 230,666 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.96 per share. | 01 Apr 2024 | 25,750 | 4,010,404 | - | 9.0 | 230,666 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.96 per share. | 01 Apr 2024 | 25,750 | 4,008,130 | - | 9.0 | 230,666 | Ordinary Shares |
| Mr. George Goldsmith | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.65 per share. | 28 Mar 2024 | 25,750 | 4,033,880 | - | 8.7 | 222,776 | Ordinary Shares |
| Mr. George Goldsmith | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.65 per share. | 28 Mar 2024 | 25,750 | 4,036,154 | - | 8.7 | 222,776 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.65 per share. | 28 Mar 2024 | 25,750 | 4,033,880 | - | 8.7 | 222,776 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.65 per share. | 28 Mar 2024 | 25,750 | 4,036,154 | - | 8.7 | 222,776 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.58 per share. | 12 Mar 2024 | 15,740 | 4,079,107 | - | 10.6 | 166,534 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.80 per share. | 12 Mar 2024 | 17,203 | 4,061,904 | - | 10.8 | 185,877 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.80 per share. | 12 Mar 2024 | 17,203 | 4,059,630 | - | 10.8 | 185,877 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.58 per share. | 12 Mar 2024 | 15,740 | 4,076,833 | - | 10.6 | 166,534 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.58 per share. | 12 Mar 2024 | 15,740 | 4,076,833 | - | 10.6 | 166,534 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.80 per share. | 12 Mar 2024 | 17,203 | 4,061,904 | - | 10.8 | 185,877 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.80 per share. | 12 Mar 2024 | 17,203 | 4,059,630 | - | 10.8 | 185,877 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.58 per share. | 12 Mar 2024 | 15,740 | 4,079,107 | - | 10.6 | 166,534 | Ordinary Shares |
| Ms. Teri Loxam | Chief Financial Officer | 01 Mar 2024 | 117,643 | 117,643 | - | - | Share Option (Right to Buy) | ||
| Ms. Teri Loxam | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 62,718 | 62,718 | - | 0 | Ordinary Shares | |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.06 per share. | 23 Feb 2024 | 11,863 | 4,112,612 | - | 10.1 | 119,335 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.06 per share. | 23 Feb 2024 | 11,863 | 4,112,612 | - | 10.1 | 119,335 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.45 per share. | 23 Feb 2024 | 17,765 | 4,092,573 | - | 10.4 | 185,602 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.45 per share. | 23 Feb 2024 | 17,765 | 4,092,573 | - | 10.4 | 185,602 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.06 per share. | 23 Feb 2024 | 11,862 | 4,110,338 | - | 10.1 | 119,325 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.45 per share. | 23 Feb 2024 | 17,765 | 4,094,847 | - | 10.4 | 185,602 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.45 per share. | 23 Feb 2024 | 17,765 | 4,094,847 | - | 10.4 | 185,602 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.06 per share. | 23 Feb 2024 | 11,862 | 4,110,338 | - | 10.1 | 119,325 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.56 per share. | 06 Feb 2024 | 22,794 | 4,124,475 | - | 10.6 | 240,753 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.56 per share. | 06 Feb 2024 | 22,794 | 4,122,200 | - | 10.6 | 240,753 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.56 per share. | 06 Feb 2024 | 22,794 | 4,122,200 | - | 10.6 | 240,753 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.59 per share. | 06 Feb 2024 | 19,852 | 4,147,269 | - | 10.6 | 210,304 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.59 per share. | 06 Feb 2024 | 19,853 | 4,144,994 | - | 10.6 | 210,315 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.56 per share. | 06 Feb 2024 | 22,794 | 4,124,475 | - | 10.6 | 240,753 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.59 per share. | 06 Feb 2024 | 19,853 | 4,144,994 | - | 10.6 | 210,315 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.59 per share. | 06 Feb 2024 | 19,852 | 4,147,269 | - | 10.6 | 210,304 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 10.89 per share. | 01 Feb 2024 | 1,597 | 4,164,847 | - | 10.9 | 17,391 | Ordinary Shares |
| Mr. Matthew A. Owens | General Counsel & CLO | 01 Feb 2024 | 76,000 | 76,000 | - | - | Share Option (Right to Buy) | ||
| Mr. Matthew A. Owens | General Counsel & CLO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.34 per share. | 01 Feb 2024 | 1,693 | 44,814 | - | 11.3 | 19,199 | Ordinary Shares |
| Mr. Kabir Nath | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 10.89 per share. | 01 Feb 2024 | 3,158 | 158,248 | - | 10.9 | 34,391 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.34 per share. | 01 Feb 2024 | 3,301 | 4,166,444 | - | 11.3 | 37,433 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.34 per share. | 01 Feb 2024 | 5,283 | 4,167,121 | - | 11.3 | 59,909 | Ordinary Shares |
| Mr. Kabir Nath | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 92,000 | 161,406 | - | 0 | Ordinary Shares | |
| Mr. Guy Goodwin | Chief Medical Officer | 01 Feb 2024 | 32,000 | 32,000 | - | - | Share Option (Right to Buy) | ||
| Mr. Matthew A. Owens | General Counsel & CLO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 10.89 per share. | 01 Feb 2024 | 1,474 | 43,340 | - | 10.9 | 16,052 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.34 per share. | 01 Feb 2024 | 5,283 | 4,167,121 | - | 11.3 | 59,909 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.34 per share. | 01 Feb 2024 | 3,301 | 4,166,444 | - | 11.3 | 37,433 | Ordinary Shares |
| Ms. Mary-Rose Hughes | Interim CFO | 01 Feb 2024 | 6,200 | 6,200 | - | - | Share Option (Right to Buy) | ||
| Dr. Annalisa Mary Jenkins, F.R.C.P.,M.B.B.S. | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.34 per share. | 01 Feb 2024 | 175 | 19,852 | - | 11.3 | 1,985 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 10.89 per share. | 01 Feb 2024 | 1,597 | 4,164,847 | - | 10.9 | 17,391 | Ordinary Shares |
| Mr. Matthew A. Owens | General Counsel & CLO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 25,000 | 46,507 | - | 0 | Ordinary Shares | |
| Mr. Kabir Nath | Director, Chief Executive Officer | 01 Feb 2024 | 275,000 | 275,000 | - | - | Share Option (Right to Buy) | ||
| Mr. Guy Goodwin | Chief Medical Officer | 01 Feb 2024 | 63,000 | 63,000 | - | - | Share Option (Right to Buy) | ||
| Ms. Mary-Rose Hughes | Interim CFO | 01 Feb 2024 | 18,700 | 18,700 | - | - | Share Option (Right to Buy) | ||
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 7.99 per share. | 19 Jan 2024 | 20,206 | 4,195,495 | - | 8.0 | 161,448 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.35 per share. | 19 Jan 2024 | 25,750 | 4,172,404 | - | 8.4 | 215,033 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.35 per share. | 19 Jan 2024 | 25,750 | 4,169,745 | - | 8.4 | 215,033 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 7.99 per share. | 19 Jan 2024 | 20,205 | 4,198,154 | - | 8.0 | 161,440 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.35 per share. | 19 Jan 2024 | 25,750 | 4,169,745 | - | 8.4 | 215,033 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.35 per share. | 19 Jan 2024 | 25,750 | 4,172,404 | - | 8.4 | 215,033 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 7.99 per share. | 19 Jan 2024 | 20,205 | 4,198,154 | - | 8.0 | 161,440 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 7.99 per share. | 19 Jan 2024 | 20,206 | 4,195,495 | - | 8.0 | 161,448 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 9.00 per share. | 02 Jan 2024 | 25,750 | 4,240,117 | - | 9.0 | 231,706 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.74 per share. | 02 Jan 2024 | 21,758 | 4,215,701 | - | 8.7 | 190,226 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.74 per share. | 02 Jan 2024 | 21,758 | 4,218,359 | - | 8.7 | 190,226 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 9.00 per share. | 02 Jan 2024 | 25,750 | 4,237,459 | - | 9.0 | 231,706 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 9.00 per share. | 02 Jan 2024 | 25,750 | 4,237,459 | - | 9.0 | 231,706 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.74 per share. | 02 Jan 2024 | 21,758 | 4,218,359 | - | 8.7 | 190,226 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.74 per share. | 02 Jan 2024 | 21,758 | 4,215,701 | - | 8.7 | 190,226 | Ordinary Shares |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 9.00 per share. | 02 Jan 2024 | 25,750 | 4,240,117 | - | 9.0 | 231,706 | Ordinary Shares |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 7.81 per share. | 13 Dec 2023 | 1,377 | 4,263,209 | - | 7.8 | 10,753 | - |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 7.82 per share. | 13 Dec 2023 | 2,855 | 4,267,244 | - | 7.8 | 22,320 | - |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 7.81 per share. | 13 Dec 2023 | 1,377 | 4,263,209 | - | 7.8 | 10,753 | - |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 7.81 per share. | 13 Dec 2023 | 1,377 | 4,265,867 | - | 7.8 | 10,753 | - |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 7.81 per share. | 13 Dec 2023 | 1,377 | 4,265,867 | - | 7.8 | 10,753 | - |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 7.82 per share. | 13 Dec 2023 | 2,855 | 4,264,586 | - | 7.8 | 22,320 | - |
| Mr. George Goldsmith | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 7.82 per share. | 13 Dec 2023 | 2,855 | 4,264,586 | - | 7.8 | 22,320 | - |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 7.82 per share. | 13 Dec 2023 | 2,855 | 4,267,244 | - | 7.8 | 22,320 | - |
| Mr. George Goldsmith | Director, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.78 per share. | 01 Nov 2023 | 1,526 | 4,267,441 | - | 5.8 | 8,820 | - |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.78 per share. | 01 Nov 2023 | 1,526 | 4,267,441 | - | 5.8 | 8,820 | - |
| Mr. George Goldsmith | Director, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.78 per share. | 01 Nov 2023 | 1,470 | 4,270,099 | - | 5.8 | 8,497 | - |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.78 per share. | 01 Nov 2023 | 1,470 | 4,270,099 | - | 5.8 | 8,497 | - |
| Dr. Annalisa Mary Jenkins | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.78 per share. | 01 Nov 2023 | 143 | 20,027 | - | 5.8 | 827 | - |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.95 per share. | 01 Aug 2023 | 1,526 | 4,268,967 | - | 9.0 | 13,658 | - |
| Dr. Ekaterina Malievskaia, M.D. | Director, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.95 per share. | 01 Aug 2023 | 1,470 | 4,271,569 | - | 9.0 | 13,157 | - |
| Mr. George Goldsmith | Director, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.95 per share. | 01 Aug 2023 | 1,526 | 4,268,967 | - | 9.0 | 13,658 | - |
| Mr. George Goldsmith | Director, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.95 per share. | 01 Aug 2023 | 1,470 | 4,271,569 | - | 9.0 | 13,157 | - |
| Dr. Annalisa Mary Jenkins | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.95 per share. | 01 Aug 2023 | 161 | 20,170 | - | 9.0 | 1,441 | - |
| Mr. Kabir Nath | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.95 per share. | 01 Aug 2023 | 5,000 | 70,200 | - | 9.0 | 44,750 | - |
| Mr. Kabir Nath | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.95 per share. | 01 Aug 2023 | 5,794 | 69,406 | - | 8.9 | 51,856 | - |
| Mr. Kabir Nath | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.95 per share. | 01 Aug 2023 | 5,000 | 70,200 | - | 9.0 | 44,750 | - |
| Mr. Kabir Nath | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.95 per share. | 01 Aug 2023 | 5,794 | 69,406 | - | 8.9 | 51,856 | - |
| Dr. Ekaterina Malievskaia, M.D. | Director, Chief Innovation Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.97 per share. | 02 May 2023 | 1,470 | 4,273,039 | - | 8.0 | 11,716 | - |
| Mr. George Goldsmith | Director, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.97 per share. | 02 May 2023 | 1,470 | 4,273,039 | - | 8.0 | 11,716 | - |
| Dr. Ekaterina Malievskaia, M.D. | Director, Chief Innovation Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.97 per share. | 02 May 2023 | 1,526 | 4,270,493 | - | 8.0 | 12,162 | - |
| Mr. George Goldsmith | Director, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.97 per share. | 02 May 2023 | 1,526 | 4,270,493 | - | 8.0 | 12,162 | - |
| Dr. Annalisa Mary Jenkins | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.96 per share. | 02 May 2023 | 25 | 20,331 | - | 8.0 | 199 | - |
| Mr. Michael Falvey | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2023 | 22,500 | 22,500 | - | 0 | - | |
| Mr. Kabir Nath | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2023 | 25,200 | 75,200 | - | 0 | - | |
| Mr. Michael Falvey | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2023 | 22,500 | 22,500 | - | 0 | - | |
| Mr. Kabir Nath | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2023 | 25,200 | 75,200 | - | 0 | - | |
| Mr. Matthew A. Owens | General Counsel & CLO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 10.61 per share. | 01 Feb 2023 | 1,693 | 10,707 | - | 10.6 | 17,963 | - |
| Mr. Matthew A. Owens | General Counsel & CLO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2023 | 10,800 | 21,507 | - | 0 | - | |
| Mr. George Goldsmith | Director, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 10.61 per share. | 20 Dec 2022 | 3,301 | 4,260,319 | - | 10.6 | 35,024 | - |
| Mr. George Goldsmith | Director, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.20 per share. | 20 Dec 2022 | 4,409 | 4,279,792 | - | 9.2 | 40,563 | - |
| Mr. George Goldsmith | Director, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.20 per share. | 20 Dec 2022 | 4,577 | 4,263,620 | - | 9.2 | 42,108 | - |
| Dr. Ekaterina Malievskaia, M.D. | Director, Chief Innovation Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 10.61 per share. | 20 Dec 2022 | 3,301 | 4,260,319 | - | 10.6 | 35,024 | - |
| Mr. George Goldsmith | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Dec 2022 | 11,700 | 4,272,019 | - | 0 | - | |
| Dr. Ekaterina Malievskaia, M.D. | Director, Chief Innovation Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.20 per share. | 20 Dec 2022 | 4,409 | 4,279,792 | - | 9.2 | 40,563 | - |
| Dr. Ekaterina Malievskaia, M.D. | Director, Chief Innovation Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 10.61 per share. | 20 Dec 2022 | 5,283 | 4,274,509 | - | 10.6 | 56,053 | - |
| Dr. Ekaterina Malievskaia, M.D. | Director, Chief Innovation Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.20 per share. | 20 Dec 2022 | 4,577 | 4,263,620 | - | 9.2 | 42,108 | - |
| Dr. Ekaterina Malievskaia, M.D. | Director, Chief Innovation Officer, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Dec 2022 | 11,700 | 4,272,019 | - | 0 | - | |
| Mr. George Goldsmith | Director, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 10.61 per share. | 20 Dec 2022 | 5,283 | 4,274,509 | - | 10.6 | 56,053 | - |
| Mr. Kabir Nath | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Aug 2022 | 50,000 | 50,000 | - | 0 | - | |
| Mr. Kabir Nath | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Aug 2022 | 50,000 | 50,000 | - | 0 | - | |
| Dr. Annalisa Mary Jenkins | Director | Sale of securities on an exchange or to another person at price $ 12.48 per share. | 29 Mar 2022 | 3,384 | 20,356 | - | 12.5 | 42,232 | - |
| Mr. David York Norton | Director | Sale of securities on an exchange or to another person at price $ 12.48 per share. | 29 Mar 2022 | 3,384 | 20,356 | - | 12.5 | 42,232 | - |
| Mr. David York Norton | Director | Sale of securities on an exchange or to another person at price $ 12.48 per share. | 29 Mar 2022 | 3,384 | 20,356 | - | 12.5 | 42,232 | - |
| Mr. George Goldsmith | Director, Chief Executive Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 12.48 per share. | 01 Feb 2022 | 6,372 | 4,284,201 | - | 12.5 | 79,523 | - |
| Dr. Ekaterina Malievskaia, M.D. | Director, Chief Innovation Officer, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2022 | 13,000 | 4,274,569 | - | 0 | - | |
| Mr. George Goldsmith | Director, Chief Executive Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 12.48 per share. | 01 Feb 2022 | 6,372 | 4,268,197 | - | 12.5 | 79,523 | - |
| Dr. Ekaterina Malievskaia, M.D. | Director, Chief Innovation Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 12.48 per share. | 01 Feb 2022 | 6,372 | 4,284,201 | - | 12.5 | 79,523 | - |
| Mr. George Goldsmith | Director, Chief Executive Officer, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2022 | 29,000 | 4,290,573 | - | 0 | - | |
| Dr. Ekaterina Malievskaia, M.D. | Director, Chief Innovation Officer, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2022 | 29,000 | 4,290,573 | - | 0 | - | |
| Mr. George Goldsmith | Director, Chief Executive Officer, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2022 | 13,000 | 4,274,569 | - | 0 | - | |
| Dr. Ekaterina Malievskaia, M.D. | Director, Chief Innovation Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 12.48 per share. | 01 Feb 2022 | 6,372 | 4,268,197 | - | 12.5 | 79,523 | - |
| Mr. Matthew A. Owens | General Counsel & CLO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2022 | 12,400 | 12,400 | - | 0 | - | |
| Mr. Guy Goodwin | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2022 | 8,000 | 8,000 | - | 0 | - | |
| Mr. Guy Goodwin | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2022 | 8,000 | 8,000 | - | 0 | - |