XNAS 04 May, 2026 11:49 AM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| James N. Wilson | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 22 Apr 2026 | 2,000 | 1,095,532 (0%) | 0% | 0 | Common Stock | |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Apr 2026 | 20,000 | 190,000 | - | - | Stock Option (right to buy) | |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 40.97 per share. | 07 Apr 2026 | 20,000 | 2,231 (0%) | 0% | 41.0 | 819,400 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 07 Apr 2026 | 20,000 | 22,231 (0%) | 0% | 21.7 | 433,000 | Common Stock |
| James N. Wilson | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 06 Apr 2026 | 5,000 | 1,097,532 (0%) | 0% | 0 | Common Stock | |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 50.07 per share. | 25 Mar 2026 | 26,198 | 2,918,326 (2%) | 0% | 50.1 | 1,311,826 | Common Stock |
| James N. Wilson | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 20 Mar 2026 | 4,000 | 1,102,532 (0%) | 0% | 0 | Common Stock | |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 36.01 per share. | 20 Mar 2026 | 11,767 | 2,231 (0%) | 0% | 36.0 | 423,730 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Mar 2026 | 11,767 | 210,000 | - | - | Stock Option (right to buy) | |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 20 Mar 2026 | 11,767 | 13,998 (0%) | 0% | 21.7 | 254,756 | Common Stock |
| George Leonard Baker | Director | Purchase of securities on an exchange or from another person at price $ 33.00 per share. | 17 Mar 2026 | 75,782 | 1,122,413 (0%) | 0% | 33.0 | 2,500,973 | Common Stock |
| George Leonard Baker | Director | Purchase of securities on an exchange or from another person at price $ 33.56 per share. | 17 Mar 2026 | 24,218 | 1,146,631 (1%) | 0% | 33.6 | 812,836 | Common Stock |
| David L. Mahoney | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 32.15 per share. | 13 Mar 2026 | 5,469 | 24,531 (0%) | 0% | 32.1 | 175,828 | Common Stock |
| David L. Mahoney | Director | Other type of transaction at price $ 0.00 per share. | 13 Mar 2026 | 24,531 | 1,237,145 (1%) | 0% | 0 | Common Stock | |
| David L. Mahoney | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 13 Mar 2026 | 24,531 | 0 (0%) | 0% | 0 | Common Stock | |
| David L. Mahoney | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.86 per share. | 13 Mar 2026 | 30,000 | 30,000 (0%) | 0% | 5.9 | 175,800 | Common Stock |
| David L. Mahoney | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2026 | 30,000 | 0 | - | - | Stock Option (right to buy) | |
| James N. Wilson | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 13 Mar 2026 | 28,000 | 1,106,532 (0%) | 0% | 0 | Common Stock | |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2026 | 8,233 | 221,767 | - | - | Stock Option (right to buy) | |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 35.99 per share. | 04 Mar 2026 | 8,233 | 2,231 (0%) | 0% | 36.0 | 296,346 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 04 Mar 2026 | 8,233 | 10,464 (0%) | 0% | 21.6 | 178,244 | Common Stock |
| G. Charles Robb | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 35.97 per share. | 02 Mar 2026 | 499 | 79,125 (0%) | 0% | 36.0 | 17,949 | Common Stock |
| G. Charles Robb | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2026 | 499 | 79,624 (0%) | 0% | 0 | Common Stock | |
| G. Charles Robb | Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.97 per share. | 02 Mar 2026 | 121 | 79,503 (0%) | 0% | 36.0 | 4,352 | Common Stock |
| Atabak Mokari | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.97 per share. | 02 Mar 2026 | 96 | 15,257 (0%) | 0% | 36.0 | 3,453 | Common Stock |
| Atabak Mokari | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 35.97 per share. | 02 Mar 2026 | 397 | 14,956 (0%) | 0% | 36.0 | 14,280 | Common Stock |
| Atabak Mokari | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2026 | 397 | 15,353 (0%) | 0% | 0 | Common Stock | |
| Sean Maduck | See Remarks | Grant, award, or other acquisition of securities at price $ 35.97 per share. | 02 Mar 2026 | 454 | 8,633 (0%) | 0% | 36.0 | 16,330 | Common Stock |
| Sean Maduck | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.97 per share. | 02 Mar 2026 | 110 | 8,977 (0%) | 0% | 36.0 | 3,957 | Common Stock |
| Sean Maduck | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2026 | 454 | 9,087 (0%) | 0% | 0 | Common Stock | |
| Joseph Douglas Lyon | See Remarks | Grant, award, or other acquisition of securities at price $ 35.97 per share. | 02 Mar 2026 | 398 | 10,921 (0%) | 0% | 36.0 | 14,316 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.97 per share. | 02 Mar 2026 | 89 | 11,230 (0%) | 0% | 36.0 | 3,201 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2026 | 398 | 11,319 (0%) | 0% | 0 | Common Stock | |
| William Guyer | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 35.97 per share. | 02 Mar 2026 | 498 | 1,733 (0%) | 0% | 36.0 | 17,913 | Common Stock |
| William Guyer | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2026 | 498 | 2,231 (0%) | 0% | 0 | Common Stock | |
| Joseph K. Belanoff | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2026 | 460,000 | 460,000 | - | - | Stock Option (right to buy) | |
| G. Charles Robb | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2026 | 140,000 | 140,000 | - | - | Stock Option (right to buy) | |
| Atabak Mokari | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2026 | 140,000 | 140,000 | - | - | Stock Option (right to buy) | |
| Sean Maduck | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2026 | 140,000 | 140,000 | - | - | Stock Option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2026 | 140,000 | 140,000 | - | - | Stock Option (right to buy) | |
| Hazel Hunt | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2026 | 140,000 | 140,000 | - | - | Stock Option (right to buy) | |
| William Guyer | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2026 | 140,000 | 140,000 | - | - | Stock Option (right to buy) | |
| James N. Wilson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.88 per share. | 24 Feb 2026 | 100,000 | 100,000 (0%) | 0% | 3.9 | 388,000 | Common Stock |
| James N. Wilson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2026 | 100,000 | 0 | - | - | Stock option (right to buy) | |
| James N. Wilson | Director | Other type of transaction at price $ 0.00 per share. | 24 Feb 2026 | 89,364 | 1,134,532 (0%) | 0% | 0 | Common Stock | |
| James N. Wilson | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 24 Feb 2026 | 89,364 | 0 (0%) | 0% | 0 | Common Stock | |
| James N. Wilson | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 36.48 per share. | 24 Feb 2026 | 10,636 | 89,364 (0%) | 0% | 36.5 | 388,001 | Common Stock |
| Hazel Hunt | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 41.31 per share. | 09 Feb 2026 | 77,968 | 255,437 (0%) | 0% | 41.3 | 3,220,858 | Common Stock |
| Hazel Hunt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.88 per share. | 09 Feb 2026 | 150,000 | 333,405 (0%) | 0% | 3.9 | 582,000 | Common Stock |
| Hazel Hunt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2026 | 150,000 | 0 | - | - | Stock Option (right to buy) | |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 03 Feb 2026 | 20,000 | 21,235 (0%) | 0% | 21.7 | 433,000 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2026 | 20,000 | 230,000 | - | - | Stock option (right to buy) | |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 40.87 per share. | 03 Feb 2026 | 20,000 | 1,235 (0%) | 0% | 40.9 | 817,334 | Common Stock |
| George Leonard Baker | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jan 2026 | 30,000 | 0 | - | - | Stock Option (Right To Buy) | |
| George Leonard Baker | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jan 2026 | 30,000 | 0 | - | - | Stock Option (Right To Buy) | |
| George Leonard Baker | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jan 2026 | 30,000 | 0 | - | - | Stock Option (Right To Buy) | |
| George Leonard Baker | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jan 2026 | 25,000 | 0 | - | - | Stock Option (Right To Buy) | |
| George Leonard Baker | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jan 2026 | 25,000 | 0 | - | - | Stock Option (Right To Buy) | |
| George Leonard Baker | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.86 per share. | 27 Jan 2026 | 30,000 | 985,262 (0%) | 0% | 5.9 | 175,800 | Common Stock |
| George Leonard Baker | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.13 per share. | 27 Jan 2026 | 30,000 | 1,015,262 (0%) | 0% | 12.1 | 363,900 | Common Stock |
| George Leonard Baker | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.08 per share. | 27 Jan 2026 | 25,000 | 1,040,262 (0%) | 0% | 14.1 | 352,000 | Common Stock |
| George Leonard Baker | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.50 per share. | 27 Jan 2026 | 25,000 | 1,065,262 (0%) | 0% | 10.5 | 262,500 | Common Stock |
| George Leonard Baker | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.15 per share. | 27 Jan 2026 | 30,000 | 1,095,262 (0%) | 0% | 15.2 | 454,500 | Common Stock |
| Sean Maduck | See Remarks | Gift of securities by or to the insider at price $ 0.00 per share. | 08 Jan 2026 | 34,000 | 5,147 (0%) | 0% | 0 | Common Stock | |
| Sean Maduck | See Remarks | Other type of transaction at price $ 0.00 per share. | 08 Jan 2026 | 34,000 | 34,000 (0%) | 0% | 0 | Common Stock | |
| Sean Maduck | See Remarks | Gift of securities by or to the insider at price $ 0.00 per share. | 08 Jan 2026 | 20,570 | 39,147 (0%) | 0% | 0 | Common Stock | |
| Sean Maduck | See Remarks | Other type of transaction at price $ 0.00 per share. | 08 Jan 2026 | 20,570 | 20,570 (0%) | 0% | 0 | Common Stock | |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 06 Jan 2026 | 20,000 | 21,235 (0%) | 0% | 21.7 | 433,000 | Common Stock |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 35.18 per share. | 06 Jan 2026 | 20,000 | 1,235 (0%) | 0% | 35.2 | 703,656 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jan 2026 | 20,000 | 250,000 | - | - | Stock option (right to buy) | |
| Joseph K. Belanoff | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 83.59 per share. | 24 Dec 2025 | 306,846 | 243,154 (0%) | 0% | 83.6 | 25,649,257 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Dec 2025 | 550,000 | 0 | - | - | Stock option (right to buy) | |
| Joseph K. Belanoff | Director, Chief Executive Officer | Other type of transaction at price $ 0.00 per share. | 24 Dec 2025 | 243,154 | 2,944,524 (2%) | 0% | 0 | Common Stock | |
| Joseph K. Belanoff | Director, Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 24 Dec 2025 | 243,154 | 0 (0%) | 0% | 0 | Common Stock | |
| Joseph K. Belanoff | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.88 per share. | 24 Dec 2025 | 550,000 | 550,000 (0%) | 0% | 3.9 | 2,134,000 | Common Stock |
| G. Charles Robb | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Dec 2025 | 145,000 | 0 | - | - | Stock option (right to buy) | |
| G. Charles Robb | Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 83.59 per share. | 24 Dec 2025 | 80,284 | 78,626 (0%) | 0% | 83.6 | 6,710,940 | Common Stock |
| G. Charles Robb | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.88 per share. | 24 Dec 2025 | 145,000 | 158,910 (0%) | 0% | 3.9 | 562,600 | Common Stock |
| James N. Wilson | Director | Other type of transaction at price $ 0.00 per share. | 12 Dec 2025 | 200,000 | 200,000 (0%) | 0% | 0 | Common Stock | |
| James N. Wilson | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 12 Dec 2025 | 400,000 | 1,045,168 (0%) | 0% | 0 | Common Stock | |
| James N. Wilson | Director | Other type of transaction at price $ 0.00 per share. | 12 Dec 2025 | 200,000 | 200,000 (0%) | 0% | 0 | Common Stock | |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 79.77 per share. | 01 Dec 2025 | 40,000 | 2,701,370 (2%) | 0% | 79.8 | 3,190,796 | Common Stock |
| G. Charles Robb | Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 79.78 per share. | 01 Dec 2025 | 148 | 13,910 (0%) | 0% | 79.8 | 11,807 | Common Stock |
| G. Charles Robb | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2025 | 224 | 14,058 (0%) | 0% | 0 | Common Stock | |
| G. Charles Robb | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 79.78 per share. | 01 Dec 2025 | 224 | 13,834 (0%) | 0% | 79.8 | 17,871 | Common Stock |
| Atabak Mokari | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 79.78 per share. | 01 Dec 2025 | 118 | 14,559 (0%) | 0% | 79.8 | 9,414 | Common Stock |
| Atabak Mokari | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2025 | 178 | 14,677 (0%) | 0% | 0 | Common Stock | |
| Atabak Mokari | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 79.78 per share. | 01 Dec 2025 | 178 | 14,499 (0%) | 0% | 79.8 | 14,201 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Dec 2025 | 20,000 | 241,986 | - | - | Stock option (right to buy) | |
| Sean Maduck | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 79.78 per share. | 01 Dec 2025 | 135 | 8,179 (0%) | 0% | 79.8 | 10,770 | Common Stock |
| Sean Maduck | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2025 | 205 | 8,314 (0%) | 0% | 0 | Common Stock | |
| Sean Maduck | See Remarks | Grant, award, or other acquisition of securities at price $ 79.78 per share. | 01 Dec 2025 | 205 | 8,109 (0%) | 0% | 79.8 | 16,355 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 79.52 per share. | 01 Dec 2025 | 20,000 | 7,904 (0%) | 0% | 79.5 | 1,590,490 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.27 per share. | 01 Dec 2025 | 20,000 | 27,904 (0%) | 0% | 8.3 | 165,400 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Dec 2025 | 5,000 | 11,571 | - | - | Stock option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 79.78 per share. | 01 Dec 2025 | 110 | 10,523 (0%) | 0% | 79.8 | 8,776 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2025 | 178 | 10,633 (0%) | 0% | 0 | Common Stock | |
| Joseph Douglas Lyon | See Remarks | Grant, award, or other acquisition of securities at price $ 79.78 per share. | 01 Dec 2025 | 178 | 10,455 (0%) | 0% | 79.8 | 14,201 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 79.53 per share. | 01 Dec 2025 | 5,000 | 10,277 (0%) | 0% | 79.5 | 397,632 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.56 per share. | 01 Dec 2025 | 5,000 | 15,277 (0%) | 0% | 13.6 | 67,800 | Common Stock |
| William Guyer | Chief Development Officer | Other type of transaction at price $ 0.00 per share. | 01 Dec 2025 | 787 | 1,235 (0%) | 0% | 0 | Common Stock | |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Dec 2025 | 20,000 | 270,000 | - | - | Stock option (right to buy) | |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 80.88 per share. | 01 Dec 2025 | 640 | 1,235 (0%) | 0% | 80.9 | 51,760 | Common Stock |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 80.05 per share. | 01 Dec 2025 | 19,360 | 1,875 (0%) | 0% | 80.0 | 1,549,766 | Common Stock |
| William Guyer | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2025 | 224 | 448 (0%) | 0% | 0 | Common Stock | |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 01 Dec 2025 | 20,000 | 21,235 (0%) | 0% | 21.7 | 433,000 | Common Stock |
| William Guyer | Chief Development Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 01 Dec 2025 | 787 | 0 (0%) | 0% | 0 | Common Stock | |
| William Guyer | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 79.78 per share. | 01 Dec 2025 | 224 | 224 (0%) | 0% | 79.8 | 17,871 | Common Stock |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 80.90 per share. | 25 Nov 2025 | 4,500 | 787 (0%) | 0% | 80.9 | 364,070 | Common Stock |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 80.90 per share. | 17 Nov 2025 | 4,500 | 787 (0%) | 0% | 80.9 | 364,070 | Common Stock |
| William Guyer | Chief Development Officer | Other type of transaction at price $ 0.00 per share. | 17 Nov 2025 | 5,287 | 5,287 (0%) | 0% | 0 | Common Stock | |
| William Guyer | Chief Development Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 17 Nov 2025 | 5,287 | 0 (0%) | 0% | 0 | Common Stock | |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 05 Nov 2025 | 20,000 | 25,287 (0%) | 0% | 21.7 | 433,000 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Nov 2025 | 20,000 | 290,000 | - | - | Stock option (right to buy) | |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 76.28 per share. | 05 Nov 2025 | 300 | 5,287 (0%) | 0% | 76.3 | 22,884 | Common Stock |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.64 per share. | 05 Nov 2025 | 13,164 | 5,587 (0%) | 0% | 75.6 | 995,679 | Common Stock |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 74.75 per share. | 05 Nov 2025 | 6,536 | 18,751 (0%) | 0% | 74.7 | 488,559 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 74.08 per share. | 03 Nov 2025 | 11,218 | 2,770,152 (2%) | 0% | 74.1 | 831,014 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 75.98 per share. | 03 Nov 2025 | 3,590 | 2,741,370 (2%) | 0% | 76.0 | 272,760 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 75.14 per share. | 03 Nov 2025 | 10,837 | 2,744,960 (2%) | 0% | 75.1 | 814,262 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 74.20 per share. | 03 Nov 2025 | 14,355 | 2,755,797 (2%) | 0% | 74.2 | 1,065,084 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Nov 2025 | 20,000 | 261,986 | - | - | Stock option (right to buy) | |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.27 per share. | 03 Nov 2025 | 20,000 | 27,904 (0%) | 0% | 8.3 | 165,400 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 73.99 per share. | 03 Nov 2025 | 20,000 | 7,904 (0%) | 0% | 74.0 | 1,479,816 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 73.65 per share. | 03 Nov 2025 | 5,000 | 10,277 (0%) | 0% | 73.6 | 368,245 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Nov 2025 | 5,000 | 16,571 | - | - | Stock option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.56 per share. | 03 Nov 2025 | 5,000 | 15,277 (0%) | 0% | 13.6 | 67,800 | Common Stock |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Oct 2025 | 2,200 | 1,100 | - | - | Stock option (right to buy) | |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.08 per share. | 10 Oct 2025 | 2,200 | 2,200 (0%) | 0% | 14.1 | 30,976 | Common Stock |
| Daniel N. Swisher | Director | Sale of securities on an exchange or to another person at price $ 87.54 per share. | 10 Oct 2025 | 2,200 | 0 (0%) | 0% | 87.5 | 192,588 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Oct 2025 | 20,000 | 310,000 | - | - | Stock option (right to buy) | |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 07 Oct 2025 | 20,000 | 25,287 (0%) | 0% | 21.7 | 433,000 | Common Stock |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 89.94 per share. | 07 Oct 2025 | 20,000 | 5,287 (0%) | 0% | 89.9 | 1,798,782 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 85.67 per share. | 01 Oct 2025 | 3,194 | 2,781,370 (2%) | 0% | 85.7 | 273,618 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 84.29 per share. | 01 Oct 2025 | 5,616 | 2,815,754 (2%) | 0% | 84.3 | 473,370 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 85.16 per share. | 01 Oct 2025 | 31,190 | 2,784,564 (2%) | 0% | 85.2 | 2,656,265 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 85.58 per share. | 01 Oct 2025 | 2,647 | 7,904 (0%) | 0% | 85.6 | 226,519 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 85.06 per share. | 01 Oct 2025 | 16,394 | 10,551 (0%) | 0% | 85.1 | 1,394,411 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 83.73 per share. | 01 Oct 2025 | 959 | 26,945 (0%) | 0% | 83.7 | 80,301 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.27 per share. | 01 Oct 2025 | 18,014 | 27,904 (0%) | 0% | 8.3 | 148,976 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.05 per share. | 01 Oct 2025 | 1,986 | 9,890 (0%) | 0% | 5.0 | 10,029 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2025 | 18,014 | 281,986 | - | - | Stock option (right to buy) | |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2025 | 1,986 | 0 | - | - | Stock option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2025 | 5,000 | 21,571 | - | - | Stock option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 85.39 per share. | 01 Oct 2025 | 600 | 10,277 (0%) | 0% | 85.4 | 51,233 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 84.92 per share. | 01 Oct 2025 | 3,473 | 10,877 (0%) | 0% | 84.9 | 294,933 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 83.71 per share. | 01 Oct 2025 | 927 | 14,350 (0%) | 0% | 83.7 | 77,600 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.56 per share. | 01 Oct 2025 | 5,000 | 15,277 (0%) | 0% | 13.6 | 67,800 | Common Stock |
| William Guyer | Chief Development Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 19 Sep 2025 | 200 | 5,287 (0%) | 0% | 0 | Common Stock | |
| Gillian M. Cannon | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 10 Sep 2025 | 7,393 | 0 (0%) | 0% | 0 | Common Stock | |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.08 per share. | 10 Sep 2025 | 2,200 | 2,200 (0%) | 0% | 14.1 | 30,976 | Common Stock |
| Daniel N. Swisher | Director | Sale of securities on an exchange or to another person at price $ 72.45 per share. | 10 Sep 2025 | 2,200 | 0 (0%) | 0% | 72.5 | 159,390 | Common Stock |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2025 | 2,200 | 3,300 | - | - | Stock option (right to buy) | |
| Gillian M. Cannon | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.99 per share. | 04 Sep 2025 | 11,000 | 11,000 (0%) | 0% | 23.0 | 252,890 | Common Stock |
| Gillian M. Cannon | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Sep 2025 | 11,000 | 49,000 | - | - | Stock option (right to buy) | |
| Gillian M. Cannon | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 70.13 per share. | 04 Sep 2025 | 3,607 | 7,393 (0%) | 0% | 70.1 | 252,959 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 71.01 per share. | 02 Sep 2025 | 700 | 2,821,370 (2%) | 0% | 71.0 | 49,707 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 70.52 per share. | 02 Sep 2025 | 39,300 | 2,822,070 (2%) | 0% | 70.5 | 2,771,326 | Common Stock |
| G. Charles Robb | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Sep 2025 | 251 | 13,866 (0%) | 0% | 0 | Common Stock | |
| G. Charles Robb | Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 71.38 per share. | 02 Sep 2025 | 256 | 13,610 (0%) | 0% | 71.4 | 18,273 | Common Stock |
| G. Charles Robb | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 71.38 per share. | 02 Sep 2025 | 251 | 13,615 (0%) | 0% | 71.4 | 17,916 | Common Stock |
| Atabak Mokari | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 71.38 per share. | 02 Sep 2025 | 200 | 14,265 (0%) | 0% | 71.4 | 14,276 | Common Stock |
| Atabak Mokari | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 71.38 per share. | 02 Sep 2025 | 144 | 14,321 (0%) | 0% | 71.4 | 10,279 | Common Stock |
| Atabak Mokari | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Sep 2025 | 200 | 14,465 (0%) | 0% | 0 | Common Stock | |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.05 per share. | 02 Sep 2025 | 20,000 | 27,681 (0%) | 0% | 5.1 | 101,000 | Common Stock |
| Sean Maduck | See Remarks | Grant, award, or other acquisition of securities at price $ 71.38 per share. | 02 Sep 2025 | 228 | 7,909 (0%) | 0% | 71.4 | 16,275 | Common Stock |
| Sean Maduck | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Sep 2025 | 228 | 8,137 (0%) | 0% | 0 | Common Stock | |
| Sean Maduck | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 71.38 per share. | 02 Sep 2025 | 233 | 7,904 (0%) | 0% | 71.4 | 16,632 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 20,000 | 1,986 | - | - | Stock option (right to buy) | |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 70.84 per share. | 02 Sep 2025 | 4,930 | 7,681 (0%) | 0% | 70.8 | 349,221 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 70.38 per share. | 02 Sep 2025 | 15,070 | 12,611 (0%) | 0% | 70.4 | 1,060,607 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 70.24 per share. | 02 Sep 2025 | 4,895 | 10,171 (0%) | 0% | 70.2 | 343,818 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.56 per share. | 02 Sep 2025 | 5,000 | 15,066 (0%) | 0% | 13.6 | 67,800 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 5,000 | 26,571 | - | - | Stock option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 71.38 per share. | 02 Sep 2025 | 189 | 10,277 (0%) | 0% | 71.4 | 13,491 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Sep 2025 | 200 | 10,466 (0%) | 0% | 0 | Common Stock | |
| Joseph Douglas Lyon | See Remarks | Grant, award, or other acquisition of securities at price $ 71.38 per share. | 02 Sep 2025 | 200 | 10,266 (0%) | 0% | 71.4 | 14,276 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 70.75 per share. | 02 Sep 2025 | 105 | 10,066 (0%) | 0% | 70.8 | 7,429 | Common Stock |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 70.85 per share. | 02 Sep 2025 | 4,406 | 5,487 (0%) | 0% | 70.8 | 312,155 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 02 Sep 2025 | 20,000 | 25,487 (0%) | 0% | 21.7 | 433,000 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 20,000 | 330,000 | - | - | Stock option (right to buy) | |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 70.39 per share. | 02 Sep 2025 | 15,594 | 9,893 (0%) | 0% | 70.4 | 1,097,693 | Common Stock |
| G. Charles Robb | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Aug 2025 | 5,000 | 145,000 | - | - | Stock option (right to buy) | |
| G. Charles Robb | Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 71.17 per share. | 22 Aug 2025 | 2,674 | 13,364 (0%) | 0% | 71.2 | 190,309 | Common Stock |
| G. Charles Robb | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 71.27 per share. | 22 Aug 2025 | 2,326 | 16,038 (0%) | 0% | 71.3 | 165,774 | Common Stock |
| G. Charles Robb | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.88 per share. | 22 Aug 2025 | 5,000 | 18,364 (0%) | 0% | 3.9 | 19,400 | Common Stock |
| Daniel N. Swisher | Director | Sale of securities on an exchange or to another person at price $ 72.30 per share. | 11 Aug 2025 | 2,200 | 0 (0%) | 0% | 72.3 | 159,060 | Common Stock |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Aug 2025 | 2,200 | 5,500 | - | - | Stock option (right to buy) | |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.08 per share. | 11 Aug 2025 | 2,200 | 2,200 (0%) | 0% | 14.1 | 30,976 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Aug 2025 | 35,007 | 350,000 | - | - | Stock option (right to buy) | |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 71.77 per share. | 08 Aug 2025 | 35,007 | 5,487 (0%) | 0% | 71.8 | 2,512,452 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 08 Aug 2025 | 35,007 | 40,494 (0%) | 0% | 21.7 | 757,902 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.64 per share. | 05 Aug 2025 | 14 | 5,501 (0%) | 0% | 21.6 | 303 | Common Stock |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 71.79 per share. | 05 Aug 2025 | 14 | 5,487 (0%) | 0% | 71.8 | 1,005 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Aug 2025 | 14 | 385,007 | - | - | Stock option (right to buy) | |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 67.81 per share. | 01 Aug 2025 | 16,745 | 2,884,625 (2%) | 0% | 67.8 | 1,135,416 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 69.65 per share. | 01 Aug 2025 | 5,446 | 2,861,370 (2%) | 0% | 69.6 | 379,305 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 68.87 per share. | 01 Aug 2025 | 17,809 | 2,866,816 (2%) | 0% | 68.9 | 1,226,486 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 67.51 per share. | 01 Aug 2025 | 5,823 | 10,066 (0%) | 0% | 67.5 | 393,128 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.56 per share. | 01 Aug 2025 | 5,823 | 15,889 (0%) | 0% | 13.6 | 78,960 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2025 | 5,823 | 31,571 | - | - | Stock option (right to buy) | |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 73.69 per share. | 17 Jul 2025 | 615 | 2,901,370 (2%) | 0% | 73.7 | 45,318 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.05 per share. | 17 Jul 2025 | 4,315 | 22,020 (0%) | 0% | 5.1 | 21,791 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2025 | 473 | 56,993 | - | - | Stock option (right to buy) | |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2025 | 4,315 | 57,466 | - | - | Stock option (right to buy) | |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 73.44 per share. | 17 Jul 2025 | 473 | 17,705 (0%) | 0% | 73.4 | 34,737 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.05 per share. | 17 Jul 2025 | 473 | 18,178 (0%) | 0% | 5.1 | 2,389 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 73.48 per share. | 17 Jul 2025 | 4,315 | 17,705 (0%) | 0% | 73.5 | 317,054 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2025 | 3,877 | 37,594 | - | - | Stock option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 73.40 per share. | 17 Jul 2025 | 200 | 10,066 (0%) | 0% | 73.4 | 14,680 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.56 per share. | 17 Jul 2025 | 200 | 10,266 (0%) | 0% | 13.6 | 2,712 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 73.48 per share. | 17 Jul 2025 | 3,877 | 10,066 (0%) | 0% | 73.5 | 284,864 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.56 per share. | 17 Jul 2025 | 3,877 | 13,943 (0%) | 0% | 13.6 | 52,572 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2025 | 200 | 37,394 | - | - | Stock option (right to buy) | |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2025 | 500 | 385,021 | - | - | Stock option (right to buy) | |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 73.44 per share. | 17 Jul 2025 | 500 | 5,487 (0%) | 0% | 73.4 | 36,721 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 17 Jul 2025 | 500 | 5,987 (0%) | 0% | 21.7 | 10,825 | Common Stock |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 73.48 per share. | 17 Jul 2025 | 4,379 | 5,487 (0%) | 0% | 73.5 | 321,774 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 17 Jul 2025 | 4,379 | 9,866 (0%) | 0% | 21.6 | 94,805 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2025 | 4,379 | 385,521 | - | - | Stock option (right to buy) | |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jul 2025 | 2,200 | 7,700 | - | - | Stock option (right to buy) | |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.08 per share. | 10 Jul 2025 | 2,200 | 2,200 (0%) | 0% | 14.1 | 30,976 | Common Stock |
| Daniel N. Swisher | Director | Sale of securities on an exchange or to another person at price $ 71.08 per share. | 10 Jul 2025 | 2,200 | 0 (0%) | 0% | 71.1 | 156,376 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.05 per share. | 01 Jul 2025 | 205 | 17,910 (0%) | 0% | 5.0 | 1,035 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2025 | 205 | 61,781 | - | - | Stock option (right to buy) | |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 73.45 per share. | 01 Jul 2025 | 205 | 17,705 (0%) | 0% | 73.5 | 15,058 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2025 | 100 | 41,471 | - | - | Stock option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.56 per share. | 01 Jul 2025 | 100 | 10,166 (0%) | 0% | 13.6 | 1,356 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 73.51 per share. | 01 Jul 2025 | 100 | 10,066 (0%) | 0% | 73.5 | 7,351 | Common Stock |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 73.51 per share. | 01 Jul 2025 | 100 | 5,487 (0%) | 0% | 73.5 | 7,351 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2025 | 100 | 389,900 | - | - | Stock option (right to buy) | |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 01 Jul 2025 | 100 | 5,587 (0%) | 0% | 21.7 | 2,165 | Common Stock |
| G. Charles Robb | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 70.77 per share. | 16 Jun 2025 | 3,185 | 13,364 (0%) | 0% | 70.8 | 225,402 | Common Stock |
| Sean Maduck | See Remarks | Gift of securities by or to the insider at price $ 0.00 per share. | 12 Jun 2025 | 40,000 | 59,717 (0%) | 0% | 0 | Common Stock | |
| Sean Maduck | See Remarks | Other type of transaction at price $ 0.00 per share. | 12 Jun 2025 | 40,000 | 40,000 (0%) | 0% | 0 | Common Stock | |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.05 per share. | 12 Jun 2025 | 35,007 | 42,688 (0%) | 0% | 5.0 | 176,785 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 67.53 per share. | 12 Jun 2025 | 27,865 | 14,823 (0%) | 0% | 67.5 | 1,881,818 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 68.52 per share. | 12 Jun 2025 | 5,428 | 9,395 (0%) | 0% | 68.5 | 371,952 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 69.70 per share. | 12 Jun 2025 | 1,714 | 7,681 (0%) | 0% | 69.7 | 119,467 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2025 | 35,007 | 21,986 | - | - | Stock option (right to buy) | |
| Sean Maduck | See Remarks | Gift of securities by or to the insider at price $ 0.00 per share. | 12 Jun 2025 | 10,024 | 7,681 (0%) | 0% | 0 | Common Stock | |
| Sean Maduck | See Remarks | Other type of transaction at price $ 0.00 per share. | 12 Jun 2025 | 10,024 | 99,717 (0%) | 0% | 0 | Common Stock | |
| David L. Mahoney | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2025 | 15,000 | 15,000 | - | - | Stock option (right to buy) | |
| Daniel N. Swisher | Director | Sale of securities on an exchange or to another person at price $ 70.61 per share. | 10 Jun 2025 | 2,200 | 0 (0%) | 0% | 70.6 | 155,342 | Common Stock |
| Daniel N. Swisher | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2025 | 15,000 | 15,000 | - | - | Stock option (right to buy) | |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 2,200 | 9,900 | - | - | Stock option (right to buy) | |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.08 per share. | 10 Jun 2025 | 2,200 | 2,200 (0%) | 0% | 14.1 | 30,976 | Common Stock |
| George Leonard Baker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2025 | 15,000 | 15,000 | - | - | Stock Option (Right To Buy) | |
| Gregg H. Alton | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2025 | 15,000 | 15,000 | - | - | Stock option (right to buy) | |
| James N. Wilson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2025 | 25,000 | 25,000 | - | - | Stock option (right to buy) | |
| Kimberly Park | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2025 | 15,000 | 15,000 | - | - | Stock option (right to buy) | |
| Gillian M. Cannon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2025 | 15,000 | 15,000 | - | - | Stock option (right to buy) | |
| Joshua M. Murray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2025 | 15,000 | 15,000 | - | - | Stock option (right to buy) | |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 20,000 | 390,000 | - | - | Stock option (right to buy) | |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 72.75 per share. | 10 Jun 2025 | 3,082 | 5,487 (0%) | 0% | 72.7 | 224,214 | Common Stock |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 72.36 per share. | 10 Jun 2025 | 16,918 | 8,569 (0%) | 0% | 72.4 | 1,224,261 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 10 Jun 2025 | 20,000 | 25,487 (0%) | 0% | 21.7 | 433,000 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 78.42 per share. | 02 Jun 2025 | 4,881 | 2,937,104 (2%) | 0% | 78.4 | 382,773 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 84.57 per share. | 02 Jun 2025 | 12,959 | 2,910,393 (2%) | 0% | 84.6 | 1,095,962 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 83.46 per share. | 02 Jun 2025 | 4,631 | 2,923,352 (2%) | 0% | 83.5 | 386,523 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 85.01 per share. | 02 Jun 2025 | 8,408 | 2,901,985 (2%) | 0% | 85.0 | 714,778 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 82.26 per share. | 02 Jun 2025 | 1,263 | 2,927,983 (2%) | 0% | 82.3 | 103,899 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 81.33 per share. | 02 Jun 2025 | 1,820 | 2,929,246 (2%) | 0% | 81.3 | 148,012 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 80.30 per share. | 02 Jun 2025 | 2,988 | 2,931,066 (2%) | 0% | 80.3 | 239,941 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 79.48 per share. | 02 Jun 2025 | 3,050 | 2,934,054 (2%) | 0% | 79.5 | 242,421 | Common Stock |
| G. Charles Robb | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2025 | 997 | 17,200 (0%) | 0% | 0 | Common Stock | |
| G. Charles Robb | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 71.68 per share. | 02 Jun 2025 | 997 | 16,203 (0%) | 0% | 71.7 | 71,465 | Common Stock |
| G. Charles Robb | Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 71.68 per share. | 02 Jun 2025 | 651 | 16,549 (0%) | 0% | 71.7 | 46,664 | Common Stock |
| Atabak Mokari | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2025 | 775 | 14,584 (0%) | 0% | 0 | Common Stock | |
| Atabak Mokari | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 71.68 per share. | 02 Jun 2025 | 519 | 14,065 (0%) | 0% | 71.7 | 37,202 | Common Stock |
| Atabak Mokari | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 71.68 per share. | 02 Jun 2025 | 775 | 13,809 (0%) | 0% | 71.7 | 55,552 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 79.89 per share. | 02 Jun 2025 | 6,246 | 19,516 (0%) | 0% | 79.9 | 498,967 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 78.87 per share. | 02 Jun 2025 | 6,191 | 25,762 (0%) | 0% | 78.9 | 488,311 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 77.91 per share. | 02 Jun 2025 | 5,752 | 31,953 (0%) | 0% | 77.9 | 448,139 | Common Stock |
| Sean Maduck | See Remarks | Grant, award, or other acquisition of securities at price $ 5.05 per share. | 02 Jun 2025 | 20,000 | 37,705 (0%) | 0% | 5.1 | 101,000 | Common Stock |
| Sean Maduck | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2025 | 888 | 17,705 (0%) | 0% | 0 | Common Stock | |
| Sean Maduck | See Remarks | Grant, award, or other acquisition of securities at price $ 71.68 per share. | 02 Jun 2025 | 888 | 16,817 (0%) | 0% | 71.7 | 63,652 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 80.77 per share. | 02 Jun 2025 | 1,811 | 17,705 (0%) | 0% | 80.8 | 146,269 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jun 2025 | 20,000 | 61,986 | - | - | Stock option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 78.65 per share. | 02 Jun 2025 | 562 | 9,009 (0%) | 0% | 78.7 | 44,204 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 77.97 per share. | 02 Jun 2025 | 4,438 | 9,751 (0%) | 0% | 78.0 | 346,014 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.56 per share. | 02 Jun 2025 | 5,000 | 14,009 (0%) | 0% | 13.6 | 67,800 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jun 2025 | 5,000 | 41,571 | - | - | Stock option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 71.68 per share. | 02 Jun 2025 | 441 | 10,066 (0%) | 0% | 71.7 | 31,611 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2025 | 749 | 10,507 (0%) | 0% | 0 | Common Stock | |
| Joseph Douglas Lyon | See Remarks | Grant, award, or other acquisition of securities at price $ 71.68 per share. | 02 Jun 2025 | 749 | 9,758 (0%) | 0% | 71.7 | 53,688 | Common Stock |
| G. Charles Robb | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 75.85 per share. | 20 May 2025 | 2,279 | 16,586 (0%) | 0% | 75.8 | 172,862 | Common Stock |
| G. Charles Robb | Chief Business Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 20 May 2025 | 360 | 11,571 (0%) | 0% | 0 | Common Stock | |
| G. Charles Robb | Chief Business Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 20 May 2025 | 360 | 11,571 (0%) | 0% | 0 | Common Stock | |
| G. Charles Robb | Chief Business Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 20 May 2025 | 1,380 | 15,206 (0%) | 0% | 0 | Common Stock | |
| David L. Mahoney | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2025 | 30,000 | 0 | - | - | Stock option (right to buy) | |
| David L. Mahoney | Director | Sale of securities on an exchange or to another person at price $ 74.65 per share. | 16 May 2025 | 3,523 | 0 (0%) | 0% | 74.7 | 263,001 | Common Stock |
| David L. Mahoney | Director | Sale of securities on an exchange or to another person at price $ 74.17 per share. | 16 May 2025 | 23,829 | 3,523 (0%) | 0% | 74.2 | 1,767,452 | Common Stock |
| David L. Mahoney | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 74.21 per share. | 16 May 2025 | 2,648 | 27,352 (0%) | 0% | 74.2 | 196,508 | Common Stock |
| David L. Mahoney | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.55 per share. | 16 May 2025 | 30,000 | 30,000 (0%) | 0% | 6.6 | 196,500 | Common Stock |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 74.17 per share. | 16 May 2025 | 32,262 | 5,487 (0%) | 0% | 74.2 | 2,393,014 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2025 | 32,262 | 410,000 | - | - | Stock option (right to buy) | |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 16 May 2025 | 32,262 | 37,749 (0%) | 0% | 21.6 | 698,472 | Common Stock |
| Daniel N. Swisher | Director | Sale of securities on an exchange or to another person at price $ 72.17 per share. | 12 May 2025 | 1,800 | 400 (0%) | 0% | 72.2 | 129,906 | Common Stock |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.08 per share. | 12 May 2025 | 400 | 2,200 (0%) | 0% | 14.1 | 5,632 | Common Stock |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.13 per share. | 12 May 2025 | 1,800 | 1,800 (0%) | 0% | 12.1 | 21,834 | Common Stock |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 May 2025 | 400 | 12,100 | - | - | Stock option (right to buy) | |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 May 2025 | 1,800 | 0 | - | - | Stock option (right to buy) | |
| Daniel N. Swisher | Director | Sale of securities on an exchange or to another person at price $ 71.55 per share. | 12 May 2025 | 400 | 0 (0%) | 0% | 71.6 | 28,620 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 06 May 2025 | 7,060 | 12,547 (0%) | 0% | 21.7 | 152,849 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 May 2025 | 7,060 | 442,262 | - | - | Stock option (right to buy) | |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 74.31 per share. | 06 May 2025 | 7,060 | 5,487 (0%) | 0% | 74.3 | 524,653 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 72.52 per share. | 02 May 2025 | 18,480 | 2,963,505 (2%) | 0% | 72.5 | 1,340,146 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 73.22 per share. | 02 May 2025 | 21,520 | 2,941,985 (2%) | 0% | 73.2 | 1,575,776 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 72.21 per share. | 01 May 2025 | 25,847 | 86,329 (0%) | 0% | 72.2 | 1,866,355 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.05 per share. | 01 May 2025 | 26,554 | 112,176 (0%) | 0% | 5.1 | 134,098 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 71.94 per share. | 01 May 2025 | 12,856 | 85,622 (0%) | 0% | 71.9 | 924,818 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.05 per share. | 01 May 2025 | 12,856 | 98,478 (0%) | 0% | 5.1 | 64,923 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2025 | 26,554 | 81,986 | - | - | Stock option (right to buy) | |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 72.98 per share. | 01 May 2025 | 707 | 85,622 (0%) | 0% | 73.0 | 51,596 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2025 | 12,856 | 108,540 | - | - | Stock option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2025 | 9,350 | 46,571 | - | - | Stock option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 71.96 per share. | 01 May 2025 | 9,350 | 9,009 (0%) | 0% | 72.0 | 672,781 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.56 per share. | 01 May 2025 | 9,350 | 18,359 (0%) | 0% | 13.6 | 126,786 | Common Stock |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Apr 2025 | 2,200 | 1,800 | - | - | Stock option (right to buy) | |
| Daniel N. Swisher | Director | Sale of securities on an exchange or to another person at price $ 70.22 per share. | 10 Apr 2025 | 2,200 | 0 (0%) | 0% | 70.2 | 154,484 | Common Stock |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.13 per share. | 10 Apr 2025 | 2,200 | 2,200 (0%) | 0% | 12.1 | 26,686 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2025 | 678 | 449,322 | - | - | Stock option (right to buy) | |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 114.51 per share. | 01 Apr 2025 | 678 | 5,487 (0%) | 0% | 114.5 | 77,639 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 01 Apr 2025 | 678 | 6,165 (0%) | 0% | 21.7 | 14,679 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 114.71 per share. | 31 Mar 2025 | 350 | 2,981,985 (2%) | 0% | 114.7 | 40,149 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 94.72 per share. | 31 Mar 2025 | 35,102 | 2,982,335 (2%) | 0% | 94.7 | 3,324,861 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 100.26 per share. | 31 Mar 2025 | 79,277 | 106,345 (0%) | 0% | 100.3 | 7,947,995 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.27 per share. | 31 Mar 2025 | 100,000 | 185,622 (0%) | 0% | 8.3 | 827,000 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Mar 2025 | 100,000 | 300,000 | - | - | Stock option (right to buy) | |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Mar 2025 | 590 | 121,396 | - | - | Stock option (right to buy) | |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 114.55 per share. | 31 Mar 2025 | 590 | 85,622 (0%) | 0% | 114.5 | 67,584 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.05 per share. | 31 Mar 2025 | 590 | 86,212 (0%) | 0% | 5.1 | 2,980 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 102.16 per share. | 31 Mar 2025 | 5,590 | 85,622 (0%) | 0% | 102.2 | 571,078 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 101.43 per share. | 31 Mar 2025 | 15,133 | 91,212 (0%) | 0% | 101.4 | 1,534,937 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Mar 2025 | 75,000 | 0 | - | - | Stock option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Mar 2025 | 650 | 55,921 | - | - | Stock option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Mar 2025 | 50,000 | 50,000 | - | - | Stock option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Mar 2025 | 40,000 | 0 | - | - | Stock option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Mar 2025 | 35,000 | 56,571 | - | - | Stock option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 114.53 per share. | 31 Mar 2025 | 650 | 9,009 (0%) | 0% | 114.5 | 74,443 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.56 per share. | 31 Mar 2025 | 650 | 9,659 (0%) | 0% | 13.6 | 8,814 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 102.48 per share. | 31 Mar 2025 | 5,050 | 9,009 (0%) | 0% | 102.5 | 517,523 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 101.37 per share. | 31 Mar 2025 | 32,942 | 14,059 (0%) | 0% | 101.4 | 3,339,416 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 100.22 per share. | 31 Mar 2025 | 162,008 | 47,001 (0%) | 0% | 100.2 | 16,236,571 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.26 per share. | 31 Mar 2025 | 50,000 | 209,009 (0%) | 0% | 19.3 | 963,000 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.82 per share. | 31 Mar 2025 | 40,000 | 159,009 (0%) | 0% | 15.8 | 632,800 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.52 per share. | 31 Mar 2025 | 75,000 | 119,009 (0%) | 0% | 16.5 | 1,239,000 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.56 per share. | 31 Mar 2025 | 35,000 | 44,009 (0%) | 0% | 13.6 | 474,600 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 60.83 per share. | 24 Mar 2025 | 1,974 | 3,017,437 (2%) | 0% | 60.8 | 120,084 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.05 per share. | 24 Mar 2025 | 1,697 | 87,319 (0%) | 0% | 5.1 | 8,570 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 60.58 per share. | 24 Mar 2025 | 1,697 | 85,622 (0%) | 0% | 60.6 | 102,804 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Mar 2025 | 1,697 | 121,986 | - | - | Stock option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 60.58 per share. | 24 Mar 2025 | 421 | 9,009 (0%) | 0% | 60.6 | 25,504 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.56 per share. | 24 Mar 2025 | 421 | 9,430 (0%) | 0% | 13.6 | 5,709 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Mar 2025 | 421 | 91,571 | - | - | Stock option (right to buy) | |
| G. Charles Robb | Chief Business Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 20 Mar 2025 | 233 | 10,898 (0%) | 0% | 0 | Common Stock | |
| G. Charles Robb | Chief Business Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 20 Mar 2025 | 233 | 10,898 (0%) | 0% | 0 | Common Stock | |
| G. Charles Robb | Chief Business Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 12 Mar 2025 | 1,000 | 10,665 (0%) | 0% | 0 | Common Stock | |
| G. Charles Robb | Chief Business Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 12 Mar 2025 | 1,000 | 10,665 (0%) | 0% | 0 | Common Stock | |
| G. Charles Robb | Chief Business Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 12 Mar 2025 | 4,625 | 18,865 (0%) | 0% | 0 | Common Stock | |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 2,200 | 4,000 | - | - | Stock option (right to buy) | |
| Daniel N. Swisher | Director | Sale of securities on an exchange or to another person at price $ 53.60 per share. | 10 Mar 2025 | 2,200 | 0 (0%) | 0% | 53.6 | 117,920 | Common Stock |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.13 per share. | 10 Mar 2025 | 2,200 | 2,200 (0%) | 0% | 12.1 | 26,686 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2025 | 350,000 | 350,000 | - | - | Stock option (right to buy) | |
| Joseph K. Belanoff | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 60.91 per share. | 28 Feb 2025 | 2,924 | 3,019,411 (2%) | 0% | 60.9 | 178,098 | Common Stock |
| G. Charles Robb | Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 60.58 per share. | 28 Feb 2025 | 250 | 22,906 (0%) | 0% | 60.6 | 15,145 | Common Stock |
| G. Charles Robb | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2025 | 140,000 | 140,000 | - | - | Stock option (right to buy) | |
| G. Charles Robb | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2025 | 292 | 23,490 (0%) | 0% | 0 | Common Stock | |
| G. Charles Robb | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 59.07 per share. | 28 Feb 2025 | 292 | 23,198 (0%) | 0% | 59.1 | 17,248 | Common Stock |
| Atabak Mokari | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2025 | 232 | 13,034 (0%) | 0% | 0 | Common Stock | |
| Atabak Mokari | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2025 | 140,000 | 140,000 | - | - | Stock option (right to buy) | |
| Atabak Mokari | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 60.58 per share. | 28 Feb 2025 | 228 | 12,570 (0%) | 0% | 60.6 | 13,812 | Common Stock |
| Atabak Mokari | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 59.07 per share. | 28 Feb 2025 | 232 | 12,802 (0%) | 0% | 59.1 | 13,704 | Common Stock |
| Sean Maduck | See Remarks | Grant, award, or other acquisition of securities at price $ 59.07 per share. | 28 Feb 2025 | 266 | 85,356 (0%) | 0% | 59.1 | 15,713 | Common Stock |
| Sean Maduck | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 60.58 per share. | 28 Feb 2025 | 228 | 85,090 (0%) | 0% | 60.6 | 13,812 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 60.69 per share. | 28 Feb 2025 | 18,303 | 85,622 (0%) | 0% | 60.7 | 1,110,818 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2025 | 18,303 | 123,683 | - | - | Stock option (right to buy) | |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.05 per share. | 28 Feb 2025 | 18,303 | 103,925 (0%) | 0% | 5.0 | 92,430 | Common Stock |
| Sean Maduck | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2025 | 140,000 | 140,000 | - | - | Stock option (right to buy) | |
| Sean Maduck | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2025 | 266 | 85,622 (0%) | 0% | 0 | Common Stock | |
| Joseph Douglas Lyon | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 60.58 per share. | 28 Feb 2025 | 182 | 8,577 (0%) | 0% | 60.6 | 11,026 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2025 | 216 | 9,009 (0%) | 0% | 0 | Common Stock | |
| Joseph Douglas Lyon | See Remarks | Grant, award, or other acquisition of securities at price $ 59.07 per share. | 28 Feb 2025 | 216 | 8,793 (0%) | 0% | 59.1 | 12,759 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.56 per share. | 28 Feb 2025 | 4,579 | 13,588 (0%) | 0% | 13.6 | 62,091 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 60.69 per share. | 28 Feb 2025 | 4,579 | 9,009 (0%) | 0% | 60.7 | 277,902 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2025 | 140,000 | 140,000 | - | - | Stock option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2025 | 4,579 | 91,992 | - | - | Stock option (right to buy) | |
| Hazel Hunt | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2025 | 140,000 | 140,000 | - | - | Stock Option (right to buy) | |
| William Guyer | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2025 | 140,000 | 140,000 | - | - | Stock option (right to buy) | |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 59.07 per share. | 28 Feb 2025 | 20,000 | 5,487 (0%) | 0% | 59.1 | 1,181,400 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.26 per share. | 28 Feb 2025 | 20,000 | 25,487 (0%) | 0% | 19.3 | 385,200 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2025 | 20,000 | 30,000 | - | - | Stock option (right to buy) | |
| Hazel Hunt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Feb 2025 | 150,000 | 0 | - | - | Stock Option (right to buy) | |
| Hazel Hunt | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 68.11 per share. | 11 Feb 2025 | 85,176 | 183,405 (0%) | 0% | 68.1 | 5,801,337 | Common Stock |
| Hazel Hunt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.29 per share. | 11 Feb 2025 | 150,000 | 268,581 (0%) | 0% | 3.3 | 493,500 | Common Stock |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.13 per share. | 10 Feb 2025 | 2,200 | 2,200 (0%) | 0% | 12.1 | 26,686 | Common Stock |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Feb 2025 | 2,200 | 6,200 | - | - | Stock option (right to buy) | |
| Daniel N. Swisher | Director | Sale of securities on an exchange or to another person at price $ 68.08 per share. | 10 Feb 2025 | 2,200 | 0 (0%) | 0% | 68.1 | 149,776 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2025 | 11,986 | 10,000 | - | - | Stock option (right to buy) | |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 66.92 per share. | 03 Feb 2025 | 20,000 | 85,318 (0%) | 0% | 66.9 | 1,338,400 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.05 per share. | 03 Feb 2025 | 8,014 | 105,318 (0%) | 0% | 5.1 | 40,471 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.88 per share. | 03 Feb 2025 | 11,986 | 97,304 (0%) | 0% | 3.9 | 46,506 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2025 | 8,014 | 141,986 | - | - | Stock option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2025 | 1,571 | 2,596 | - | - | Stock option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 66.92 per share. | 03 Feb 2025 | 5,000 | 8,759 (0%) | 0% | 66.9 | 334,600 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.56 per share. | 03 Feb 2025 | 3,429 | 13,759 (0%) | 0% | 13.6 | 46,497 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.35 per share. | 03 Feb 2025 | 1,571 | 10,330 (0%) | 0% | 11.4 | 17,831 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2025 | 3,429 | 96,571 | - | - | Stock option (right to buy) | |
| James N. Wilson | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 27 Jan 2025 | 7,800 | 1,445,168 (1%) | 0% | 0 | Common Stock | |
| G. Charles Robb | Chief Business Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 27 Jan 2025 | 313 | 11,211 (0%) | 0% | 0 | Common Stock | |
| G. Charles Robb | Chief Business Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 27 Jan 2025 | 313 | 11,211 (0%) | 0% | 0 | Common Stock | |
| James N. Wilson | Director | Other type of transaction at price $ 0.00 per share. | 22 Jan 2025 | 146,742 | 1,452,968 (1%) | 0% | 0 | Common Stock | |
| James N. Wilson | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 22 Jan 2025 | 146,742 | 0 (0%) | 0% | 0 | Common Stock | |
| James N. Wilson | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 59.03 per share. | 22 Jan 2025 | 103,258 | 146,742 (0%) | 0% | 59.0 | 6,095,320 | Common Stock |
| James N. Wilson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.29 per share. | 22 Jan 2025 | 250,000 | 250,000 (0%) | 0% | 3.3 | 822,500 | Common Stock |
| James N. Wilson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Jan 2025 | 250,000 | 0 | - | - | Stock option (right to buy) | |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.13 per share. | 10 Jan 2025 | 2,200 | 2,200 (0%) | 0% | 12.1 | 26,686 | Common Stock |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jan 2025 | 2,200 | 8,400 | - | - | Stock option (right to buy) | |
| Daniel N. Swisher | Director | Sale of securities on an exchange or to another person at price $ 50.54 per share. | 10 Jan 2025 | 2,200 | 0 (0%) | 0% | 50.5 | 111,188 | Common Stock |
| G. Charles Robb | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 50.50 per share. | 02 Jan 2025 | 11,000 | 20,119 (0%) | 0% | 50.5 | 555,552 | Common Stock |
| G. Charles Robb | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 3,037 | 0 | - | - | Stock option (right to buy) | |
| G. Charles Robb | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 11,000 | 3,037 | - | - | Stock option (right to buy) | |
| G. Charles Robb | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.29 per share. | 02 Jan 2025 | 3,037 | 23,156 (0%) | 0% | 3.3 | 9,992 | Common Stock |
| G. Charles Robb | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.29 per share. | 02 Jan 2025 | 11,000 | 31,119 (0%) | 0% | 3.3 | 36,190 | Common Stock |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 20,000 | 21,986 | - | - | Stock option (right to buy) | |
| Sean Maduck | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.88 per share. | 02 Jan 2025 | 20,000 | 105,318 (0%) | 0% | 3.9 | 77,600 | Common Stock |
| Sean Maduck | See Remarks | Sale of securities on an exchange or to another person at price $ 50.39 per share. | 02 Jan 2025 | 20,000 | 85,318 (0%) | 0% | 50.4 | 1,007,800 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 5,000 | 4,167 | - | - | Stock option (right to buy) | |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 50.39 per share. | 02 Jan 2025 | 5,000 | 8,759 (0%) | 0% | 50.4 | 251,950 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.35 per share. | 02 Jan 2025 | 5,000 | 13,759 (0%) | 0% | 11.4 | 56,750 | Common Stock |
| Joseph K. Belanoff | Director, Chief Executive Officer | 31 Dec 2024 | 348,811 | 2,831,918 (2%) | 0% | 0 | Common Stock | ||
| Joseph K. Belanoff | Director, Chief Executive Officer | 31 Dec 2024 | 190,417 | 3,022,335 (2%) | 0% | 0 | Common Stock | ||
| Joseph K. Belanoff | Director, Chief Executive Officer | 31 Dec 2024 | 190,417 | 0 (0%) | 0% | 0 | Common Stock | ||
| Joseph K. Belanoff | Director, Chief Executive Officer | 31 Dec 2024 | 348,811 | 190,417 (0%) | 0% | 0 | Common Stock | ||
| James N. Wilson | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 27 Dec 2024 | 7,800 | 1,306,226 (1%) | 0% | 0 | Common Stock | |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2024 | 2,200 | 10,600 | - | - | Stock option (right to buy) | |
| Daniel N. Swisher | Director | Sale of securities on an exchange or to another person at price $ 59.46 per share. | 10 Dec 2024 | 2,200 | 0 (0%) | 0% | 59.5 | 130,812 | Common Stock |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.13 per share. | 10 Dec 2024 | 2,200 | 2,200 (0%) | 0% | 12.1 | 26,686 | Common Stock |
| G. Charles Robb | Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 57.68 per share. | 02 Dec 2024 | 324 | 19,539 (0%) | 0% | 57.7 | 18,688 | Common Stock |
| G. Charles Robb | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 59.21 per share. | 02 Dec 2024 | 290 | 19,829 (0%) | 0% | 59.2 | 17,171 | Common Stock |
| G. Charles Robb | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Dec 2024 | 290 | 20,119 (0%) | 0% | 0 | Common Stock | |
| Atabak Mokari | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 57.68 per share. | 02 Dec 2024 | 182 | 12,336 (0%) | 0% | 57.7 | 10,498 | Common Stock |
| Atabak Mokari | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Dec 2024 | 231 | 12,798 (0%) | 0% | 0 | Common Stock | |
| Atabak Mokari | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 59.21 per share. | 02 Dec 2024 | 231 | 12,567 (0%) | 0% | 59.2 | 13,678 | Common Stock |
| Sean Maduck | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Dec 2024 | 265 | 85,318 (0%) | 0% | 0 | Common Stock | |
| Sean Maduck | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 57.68 per share. | 02 Dec 2024 | 295 | 84,788 (0%) | 0% | 57.7 | 17,016 | Common Stock |
| Sean Maduck | See Remarks | Grant, award, or other acquisition of securities at price $ 59.21 per share. | 02 Dec 2024 | 265 | 85,053 (0%) | 0% | 59.2 | 15,691 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Grant, award, or other acquisition of securities at price $ 59.21 per share. | 02 Dec 2024 | 215 | 8,544 (0%) | 0% | 59.2 | 12,730 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 57.68 per share. | 02 Dec 2024 | 165 | 8,329 (0%) | 0% | 57.7 | 9,517 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Dec 2024 | 215 | 8,759 (0%) | 0% | 0 | Common Stock | |
| William Guyer | Chief Development Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 57.68 per share. | 02 Dec 2024 | 309 | 5,487 (0%) | 0% | 57.7 | 17,823 | Common Stock |
| G. Charles Robb | Chief Business Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 22 Nov 2024 | 300 | 19,863 (0%) | 0% | 0 | Common Stock | |
| G. Charles Robb | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 56.20 per share. | 22 Nov 2024 | 2,609 | 20,163 (0%) | 0% | 56.2 | 146,626 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Sale of securities on an exchange or to another person at price $ 56.72 per share. | 22 Nov 2024 | 1,411 | 8,494 (0%) | 0% | 56.7 | 80,032 | Common Stock |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.13 per share. | 11 Nov 2024 | 2,200 | 2,200 (0%) | 0% | 12.1 | 26,686 | Common Stock |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Nov 2024 | 2,200 | 12,800 | - | - | Stock option (right to buy) | |
| Daniel N. Swisher | Director | Sale of securities on an exchange or to another person at price $ 59.88 per share. | 11 Nov 2024 | 2,200 | 0 (0%) | 0% | 59.9 | 131,736 | Common Stock |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 48.97 per share. | 01 Nov 2024 | 6,606 | 5,796 (0%) | 0% | 49.0 | 323,496 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2024 | 6,606 | 453,394 | - | - | Stock option (right to buy) | |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2024 | 3,394 | 450,000 | - | - | Stock option (right to buy) | |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 01 Nov 2024 | 3,394 | 9,190 (0%) | 0% | 21.6 | 73,480 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 01 Nov 2024 | 6,606 | 12,402 (0%) | 0% | 21.7 | 143,020 | Common Stock |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 48.97 per share. | 01 Nov 2024 | 3,394 | 5,796 (0%) | 0% | 49.0 | 166,204 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 01 Oct 2024 | 10,000 | 15,796 (0%) | 0% | 21.7 | 216,500 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2024 | 10,000 | 460,000 | - | - | Stock option (right to buy) | |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 46.28 per share. | 01 Oct 2024 | 10,000 | 5,796 (0%) | 0% | 46.3 | 462,800 | Common Stock |
| G. Charles Robb | Chief Business Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 27 Sep 2024 | 415 | 9,665 (0%) | 0% | 0 | Common Stock | |
| G. Charles Robb | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Sep 2024 | 11,000 | 14,037 | - | - | Stock option (right to buy) | |
| G. Charles Robb | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.29 per share. | 27 Sep 2024 | 11,000 | 33,772 (0%) | 0% | 3.3 | 36,190 | Common Stock |
| G. Charles Robb | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 46.28 per share. | 27 Sep 2024 | 11,000 | 22,772 (0%) | 0% | 46.3 | 509,080 | Common Stock |
| G. Charles Robb | Chief Business Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 27 Sep 2024 | 415 | 9,665 (0%) | 0% | 0 | Common Stock | |
| G. Charles Robb | Chief Business Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 17 Sep 2024 | 300 | 23,642 (0%) | 0% | 0 | Common Stock | |
| G. Charles Robb | Chief Business Officer | Other type of transaction at price $ 0.00 per share. | 17 Sep 2024 | 7,250 | 0 (0%) | 0% | 0 | Common Stock | |
| G. Charles Robb | Chief Business Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 17 Sep 2024 | 870 | 22,772 (0%) | 0% | 0 | Common Stock | |
| G. Charles Robb | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Sep 2024 | 503 | 23,942 (0%) | 0% | 0 | Common Stock | |
| G. Charles Robb | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 34.26 per share. | 03 Sep 2024 | 503 | 23,439 (0%) | 0% | 34.3 | 17,233 | Common Stock |
| G. Charles Robb | Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.30 per share. | 03 Sep 2024 | 254 | 22,936 (0%) | 0% | 35.3 | 8,966 | Common Stock |
| Atabak Mokari | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.30 per share. | 03 Sep 2024 | 143 | 11,718 (0%) | 0% | 35.3 | 5,048 | Common Stock |
| Atabak Mokari | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Sep 2024 | 400 | 12,518 (0%) | 0% | 0 | Common Stock | |
| Atabak Mokari | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 34.26 per share. | 03 Sep 2024 | 400 | 12,118 (0%) | 0% | 34.3 | 13,704 | Common Stock |
| Sean Maduck | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Sep 2024 | 458 | 85,083 (0%) | 0% | 0 | Common Stock | |
| Sean Maduck | See Remarks | Grant, award, or other acquisition of securities at price $ 34.26 per share. | 03 Sep 2024 | 458 | 84,625 (0%) | 0% | 34.3 | 15,691 | Common Stock |
| Sean Maduck | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.30 per share. | 03 Sep 2024 | 232 | 84,167 (0%) | 0% | 35.3 | 8,190 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.30 per share. | 03 Sep 2024 | 129 | 9,161 (0%) | 0% | 35.3 | 4,554 | Common Stock |
| Joseph Douglas Lyon | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Sep 2024 | 372 | 9,905 (0%) | 0% | 0 | Common Stock | |
| Joseph Douglas Lyon | See Remarks | Grant, award, or other acquisition of securities at price $ 34.26 per share. | 03 Sep 2024 | 372 | 9,533 (0%) | 0% | 34.3 | 12,745 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 03 Sep 2024 | 10,000 | 16,039 (0%) | 0% | 21.7 | 216,500 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2024 | 10,000 | 470,000 | - | - | Stock option (right to buy) | |
| William Guyer | Chief Development Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.30 per share. | 03 Sep 2024 | 243 | 5,796 (0%) | 0% | 35.3 | 8,578 | Common Stock |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 35.30 per share. | 03 Sep 2024 | 10,000 | 6,039 (0%) | 0% | 35.3 | 353,000 | Common Stock |
| G. Charles Robb | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 35.71 per share. | 26 Aug 2024 | 3,101 | 23,190 (0%) | 0% | 35.7 | 110,737 | Common Stock |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.86 per share. | 01 Aug 2024 | 150 | 150 (0%) | 0% | 5.9 | 879 | Common Stock |
| Daniel N. Swisher | Director | Sale of securities on an exchange or to another person at price $ 38.50 per share. | 01 Aug 2024 | 150 | 0 (0%) | 0% | 38.5 | 5,775 | Common Stock |
| Daniel N. Swisher | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2024 | 150 | 0 | - | - | Stock option (right to buy) | |
| Hazel Hunt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2024 | 60,000 | 0 | - | - | Stock Option (right to buy) | |
| Hazel Hunt | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.94 per share. | 01 Aug 2024 | 34,773 | 118,581 (0%) | 0% | 37.9 | 1,319,288 | Common Stock |
| Hazel Hunt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.81 per share. | 01 Aug 2024 | 60,000 | 153,354 (0%) | 0% | 2.8 | 168,600 | Common Stock |
| William Guyer | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 38.67 per share. | 01 Aug 2024 | 10,000 | 6,039 (0%) | 0% | 38.7 | 386,700 | Common Stock |
| William Guyer | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.65 per share. | 01 Aug 2024 | 10,000 | 16,039 (0%) | 0% | 21.7 | 216,500 | Common Stock |