XNAS 05 May, 2026 1:41 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 65.00 per share. | 01 May 2026 | 15,857 | 58,555 (0%) | 0% | 65 | 1,030,705 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2026 | 15,857 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.63 per share. | 01 May 2026 | 15,857 | 74,412 (0%) | 0% | 37.6 | 596,699 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 63.26 per share. | 30 Apr 2026 | 15,000 | 58,555 (0%) | 0% | 63.3 | 948,900 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2026 | 15,000 | 54,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.26 per share. | 30 Apr 2026 | 15,000 | 73,555 (0%) | 0% | 23.3 | 348,900 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 59.62 per share. | 29 Apr 2026 | 7,500 | 407,830 (0%) | 0% | 59.6 | 447,150 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 65.69 per share. | 21 Apr 2026 | 3,500 | 153,902 (0%) | 0% | 65.7 | 229,915 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Apr 2026 | 3,500 | 54,886 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.80 per share. | 21 Apr 2026 | 3,500 | 157,402 (0%) | 0% | 7.8 | 27,300 | Common Stock |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 65.37 per share. | 15 Apr 2026 | 325 | 75,237 (0%) | 0% | 65.4 | 21,245 | Common Stock |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 65.37 per share. | 15 Apr 2026 | 95 | 31,066 (0%) | 0% | 65.4 | 6,210 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 65.38 per share. | 15 Apr 2026 | 7,500 | 415,330 (0%) | 0% | 65.4 | 490,350 | Common Stock |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 65.37 per share. | 15 Apr 2026 | 95 | 32,637 (0%) | 0% | 65.4 | 6,210 | Common Stock |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 65.37 per share. | 15 Apr 2026 | 191 | 10,365 (0%) | 0% | 65.4 | 12,486 | Common Stock |
| James M. Daly | Director | Grant, award, or other acquisition of securities at price $ 65.37 per share. | 15 Apr 2026 | 191 | 388 (0%) | 0% | 65.4 | 12,486 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 66.02 per share. | 15 Apr 2026 | 7,449 | 58,555 (0%) | 0% | 66.0 | 491,783 | Common Stock |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 65.37 per share. | 15 Apr 2026 | 191 | 18,930 (0%) | 0% | 65.4 | 12,486 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.80 per share. | 07 Apr 2026 | 3,500 | 157,402 (0%) | 0% | 7.8 | 27,300 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Apr 2026 | 1,000 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Apr 2026 | 3,500 | 58,386 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 64.75 per share. | 07 Apr 2026 | 1,000 | 153,902 (0%) | 0% | 64.8 | 64,750 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 07 Apr 2026 | 1,000 | 154,902 (0%) | 0% | 10.6 | 10,600 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 65.21 per share. | 07 Apr 2026 | 3,500 | 153,902 (0%) | 0% | 65.2 | 228,235 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 66.63 per share. | 01 Apr 2026 | 7,500 | 422,830 (0%) | 0% | 66.6 | 499,725 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 65.00 per share. | 31 Mar 2026 | 3,639 | 66,004 (0%) | 0% | 65 | 236,535 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 62.07 per share. | 18 Mar 2026 | 1,930 | 78,185 (0%) | 0% | 62.1 | 119,795 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 62.15 per share. | 17 Mar 2026 | 12,673 | 454,258 (0%) | 0% | 62.2 | 787,627 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 62.15 per share. | 17 Mar 2026 | 23,928 | 430,330 (0%) | 0% | 62.1 | 1,487,125 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 62.15 per share. | 17 Mar 2026 | 4,397 | 153,902 (0%) | 0% | 62.2 | 273,274 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 62.15 per share. | 17 Mar 2026 | 7,636 | 158,299 (0%) | 0% | 62.1 | 474,577 | Common Stock |
| Sung H. Lee | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 62.15 per share. | 17 Mar 2026 | 4,935 | 87,127 (0%) | 0% | 62.1 | 306,710 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 62.15 per share. | 17 Mar 2026 | 5,626 | 74,489 (0%) | 0% | 62.2 | 349,656 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 62.15 per share. | 17 Mar 2026 | 2,916 | 71,573 (0%) | 0% | 62.1 | 181,229 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 61.03 per share. | 16 Mar 2026 | 1,709 | 46,149 (0%) | 0% | 61.0 | 104,300 | Common Stock |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2026 | 75,258 | 466,931 (0%) | 0% | 0 | Common Stock | |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2026 | 111,864 | 111,864 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2026 | 1,665 | 1,665 | - | - | Incentive Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2026 | 39,527 | 39,527 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2026 | 27,306 | 165,935 (0%) | 0% | 0 | Common Stock | |
| Fady Ibraham Malik | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2026 | 1,665 | 1,665 | - | - | Incentive Stock Option (Right to Buy) | |
| Jeffrey J. Hessekiel | Chief Legal & Admin Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2026 | 22,820 | 22,820 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Jeffrey J. Hessekiel | Chief Legal & Admin Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2026 | 8,325 | 8,325 | - | - | Incentive Stock Option (Right to Buy) | |
| Jeffrey J. Hessekiel | Chief Legal & Admin Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2026 | 20,646 | 107,943 (0%) | 0% | 0 | Common Stock | |
| Sung H. Lee | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2026 | 1,665 | 1,665 | - | - | Incentive Stock Option (Right to Buy) | |
| Sung H. Lee | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2026 | 20,646 | 92,062 (0%) | 0% | 0 | Common Stock | |
| Sung H. Lee | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2026 | 29,480 | 29,480 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2026 | 29,480 | 29,480 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2026 | 1,665 | 1,665 | - | - | Incentive Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2026 | 13,320 | 81,824 (0%) | 0% | 0 | Common Stock | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Mar 2026 | 20,646 | 68,504 (0%) | 0% | 0 | Common Stock | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 60.72 per share. | 09 Mar 2026 | 7,931 | 391,673 (0%) | 0% | 60.7 | 481,570 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 60.72 per share. | 09 Mar 2026 | 2,907 | 138,629 (0%) | 0% | 60.7 | 176,513 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 60.72 per share. | 09 Mar 2026 | 2,582 | 47,858 (0%) | 0% | 60.7 | 156,779 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.26 per share. | 05 Mar 2026 | 15,000 | 65,440 (0%) | 0% | 23.3 | 348,900 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2026 | 15,000 | 69,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2026 | 11,000 | 24,403 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 39.13 per share. | 05 Mar 2026 | 11,000 | 76,440 (0%) | 0% | 39.1 | 430,430 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 61.88 per share. | 05 Mar 2026 | 11,000 | 50,440 (0%) | 0% | 61.9 | 680,680 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 61.87 per share. | 05 Mar 2026 | 15,000 | 61,440 (0%) | 0% | 61.9 | 928,050 | Common Stock |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 61.21 per share. | 02 Mar 2026 | 5,000 | 17,933 (0%) | 0% | 61.2 | 306,050 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Mar 2026 | 886 | 0 | - | - | Incentive Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 61.62 per share. | 02 Mar 2026 | 886 | 50,440 (0%) | 0% | 61.6 | 54,595 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.63 per share. | 02 Mar 2026 | 886 | 51,326 (0%) | 0% | 37.6 | 33,340 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2026 | 15,000 | 84,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 61.93 per share. | 05 Feb 2026 | 15,000 | 50,440 (0%) | 0% | 61.9 | 928,950 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.26 per share. | 05 Feb 2026 | 15,000 | 65,440 (0%) | 0% | 23.3 | 348,900 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.63 per share. | 02 Feb 2026 | 886 | 51,326 (0%) | 0% | 37.6 | 33,340 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Feb 2026 | 886 | 886 | - | - | Incentive Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 62.10 per share. | 02 Feb 2026 | 886 | 50,440 (0%) | 0% | 62.1 | 55,021 | Common Stock |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 63.44 per share. | 15 Jan 2026 | 334 | 74,912 (0%) | 0% | 63.4 | 21,189 | Common Stock |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 63.44 per share. | 15 Jan 2026 | 98 | 30,971 (0%) | 0% | 63.4 | 6,217 | Common Stock |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 63.44 per share. | 15 Jan 2026 | 98 | 32,542 (0%) | 0% | 63.4 | 6,217 | Common Stock |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 63.44 per share. | 15 Jan 2026 | 197 | 10,174 (0%) | 0% | 63.4 | 12,498 | Common Stock |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 63.44 per share. | 15 Jan 2026 | 197 | 18,739 (0%) | 0% | 63.4 | 12,498 | Common Stock |
| James M. Daly | Director | Grant, award, or other acquisition of securities at price $ 63.44 per share. | 15 Jan 2026 | 197 | 197 (0%) | 0% | 63.4 | 12,498 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.26 per share. | 05 Jan 2026 | 15,000 | 65,440 (0%) | 0% | 23.3 | 348,900 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 60.28 per share. | 05 Jan 2026 | 15,000 | 50,440 (0%) | 0% | 60.3 | 904,200 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2026 | 15,000 | 99,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Andrew Callos M. | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2026 | 885 | 1,772 | - | - | Incentive Stock Option (Right to Buy) | |
| Andrew Callos M. | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.63 per share. | 02 Jan 2026 | 885 | 51,325 (0%) | 0% | 37.6 | 33,303 | Common Stock |
| Andrew Callos M. | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 62.09 per share. | 02 Jan 2026 | 913 | 50,440 (0%) | 0% | 62.1 | 56,688 | Common Stock |
| Callos M. Andrew | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 63.16 per share. | 02 Jan 2026 | 885 | 50,440 (0%) | 0% | 63.2 | 55,897 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 62.44 per share. | 29 Dec 2025 | 1,809 | 51,353 (0%) | 0% | 62.4 | 112,954 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 22 Dec 2025 | 54,727 | 404,929 (0%) | 0% | 6.7 | 365,029 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Dec 2025 | 54,727 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Dec 2025 | 16,506 | 0 | - | - | Incentive Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 22 Dec 2025 | 16,506 | 391,009 (0%) | 0% | 6.7 | 110,095 | Common Stock |
| Robert I. Blum | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 68.18 per share. | 22 Dec 2025 | 30,426 | 374,503 (0%) | 0% | 68.2 | 2,074,445 | Common Stock |
| Wendell D. Wierenga | Director | Sale of securities on an exchange or to another person at price $ 66.14 per share. | 22 Dec 2025 | 20,000 | 32,444 (0%) | 0% | 66.1 | 1,322,800 | Common Stock |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Dec 2025 | 20,000 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.61 per share. | 22 Dec 2025 | 20,000 | 52,444 (0%) | 0% | 7.6 | 152,200 | Common Stock |
| Robert I. Blum | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 62.72 per share. | 22 Dec 2025 | 2,935 | 399,604 (0%) | 0% | 62.7 | 184,083 | Common Stock |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Dec 2025 | 5,765 | 402,539 (0%) | 0% | 0 | Common Stock | |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Dec 2025 | 5,765 | 396,774 (0%) | 0% | 0 | Common Stock | |
| Fady Ibraham Malik | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Dec 2025 | 2,000 | 140,552 (0%) | 0% | 0 | Common Stock | |
| Fady Ibraham Malik | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Dec 2025 | 2,000 | 142,552 (0%) | 0% | 0 | Common Stock | |
| Fady Ibraham Malik | EVP Research & Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 62.72 per share. | 22 Dec 2025 | 1,016 | 141,536 (0%) | 0% | 62.7 | 63,724 | Common Stock |
| Sung H. Lee | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Dec 2025 | 2,152 | 70,069 (0%) | 0% | 0 | Common Stock | |
| Sung H. Lee | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Dec 2025 | 2,152 | 72,221 (0%) | 0% | 0 | Common Stock | |
| Sung H. Lee | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 62.72 per share. | 22 Dec 2025 | 805 | 71,416 (0%) | 0% | 62.7 | 50,490 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Dec 2025 | 1,589 | 52,249 (0%) | 0% | 0 | Common Stock | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 62.72 per share. | 22 Dec 2025 | 675 | 53,162 (0%) | 0% | 62.7 | 42,336 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Dec 2025 | 1,588 | 53,837 (0%) | 0% | 0 | Common Stock | |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Dec 2025 | 2,200 | 0 | - | - | Incentive Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 61.24 per share. | 16 Dec 2025 | 2,200 | 138,552 (0%) | 0% | 61.2 | 134,728 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 16 Dec 2025 | 2,200 | 140,752 (0%) | 0% | 10.6 | 23,320 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 39.13 per share. | 08 Dec 2025 | 1,042 | 51,702 (0%) | 0% | 39.1 | 40,773 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Dec 2025 | 1,042 | 35,403 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 65.96 per share. | 08 Dec 2025 | 1,042 | 50,660 (0%) | 0% | 66.0 | 68,730 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.26 per share. | 05 Dec 2025 | 15,000 | 65,660 (0%) | 0% | 23.3 | 348,900 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2025 | 10,628 | 2,657 | - | - | Incentive Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2025 | 15,858 | 15,857 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2025 | 11,000 | 36,445 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2025 | 15,000 | 114,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 65.95 per share. | 05 Dec 2025 | 52,486 | 50,660 (0%) | 0% | 66.0 | 3,461,452 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.63 per share. | 05 Dec 2025 | 10,628 | 103,146 (0%) | 0% | 37.6 | 399,932 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.63 per share. | 05 Dec 2025 | 15,858 | 92,518 (0%) | 0% | 37.6 | 596,737 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 39.13 per share. | 05 Dec 2025 | 11,000 | 76,660 (0%) | 0% | 39.1 | 430,430 | Common Stock |
| Robert I. Blum | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 65.02 per share. | 03 Dec 2025 | 5,930 | 350,202 (0%) | 0% | 65.0 | 385,569 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 65.02 per share. | 03 Dec 2025 | 2,058 | 138,552 (0%) | 0% | 65.0 | 133,811 | Common Stock |
| Sung H. Lee | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 65.02 per share. | 03 Dec 2025 | 1,560 | 67,917 (0%) | 0% | 65.0 | 101,431 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 65.02 per share. | 03 Dec 2025 | 1,368 | 50,660 (0%) | 0% | 65.0 | 88,947 | Common Stock |
| John T. Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Dec 2025 | 8,750 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| John T. Henderson | Director | Sale of securities on an exchange or to another person at price $ 63.90 per share. | 02 Dec 2025 | 8,750 | 74,578 (0%) | 0% | 63.9 | 559,125 | Common Stock |
| John T. Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.00 per share. | 02 Dec 2025 | 8,750 | 83,328 (0%) | 0% | 10 | 87,500 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 02 Dec 2025 | 2,200 | 142,810 (0%) | 0% | 10.6 | 23,320 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Dec 2025 | 2,200 | 2,200 | - | - | Incentive Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 63.89 per share. | 02 Dec 2025 | 2,200 | 140,610 (0%) | 0% | 63.9 | 140,558 | Common Stock |
| Edward M. Kaye | Director | Sale of securities on an exchange or to another person at price $ 66.72 per share. | 01 Dec 2025 | 28,064 | 9,977 (0%) | 0% | 66.7 | 1,872,430 | Common Stock |
| Edward M. Kaye | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Dec 2025 | 20,000 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Edward M. Kaye | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Dec 2025 | 8,064 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Edward M. Kaye | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.25 per share. | 01 Dec 2025 | 20,000 | 38,041 (0%) | 0% | 14.3 | 285,000 | Common Stock |
| Edward M. Kaye | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.40 per share. | 01 Dec 2025 | 8,064 | 18,041 (0%) | 0% | 12.4 | 99,994 | Common Stock |
| Robert A. Harrington | Director | Sale of securities on an exchange or to another person at price $ 66.80 per share. | 01 Dec 2025 | 2,150 | 18,542 (0%) | 0% | 66.8 | 143,620 | Common Stock |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 64.73 per share. | 19 Nov 2025 | 5,000 | 22,933 (0%) | 0% | 64.7 | 323,650 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Nov 2025 | 2,200 | 4,400 | - | - | Incentive Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 66.45 per share. | 18 Nov 2025 | 2,200 | 140,610 (0%) | 0% | 66.5 | 146,190 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 18 Nov 2025 | 2,200 | 142,810 (0%) | 0% | 10.6 | 23,320 | Common Stock |
| Jeffrey J. Hessekiel | Chief Legal & Admin Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Nov 2025 | 87,297 | 87,297 (0%) | 0% | 0 | Common Stock | |
| Edward M. Kaye | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Nov 2025 | 5,175 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Edward M. Kaye | Director | Sale of securities on an exchange or to another person at price $ 65.08 per share. | 11 Nov 2025 | 5,175 | 9,977 (0%) | 0% | 65.1 | 336,789 | Common Stock |
| Edward M. Kaye | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.66 per share. | 11 Nov 2025 | 5,175 | 15,152 (0%) | 0% | 9.7 | 49,991 | Common Stock |
| Robert I. Blum | Director, President & CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 05 Nov 2025 | 2,000 | 356,108 (0%) | 0% | 0 | Common Stock | |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Nov 2025 | 2,295 | 6,600 | - | - | Incentive Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 59.55 per share. | 04 Nov 2025 | 2,295 | 140,610 (0%) | 0% | 59.5 | 136,667 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 04 Nov 2025 | 2,295 | 142,905 (0%) | 0% | 10.6 | 24,327 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 62.86 per share. | 30 Oct 2025 | 5,000 | 358,108 (0%) | 0% | 62.9 | 314,300 | Common Stock |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Oct 2025 | 4,375 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Wendell D. Wierenga | Director | Sale of securities on an exchange or to another person at price $ 58.68 per share. | 27 Oct 2025 | 4,375 | 32,444 (0%) | 0% | 58.7 | 256,725 | Common Stock |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.00 per share. | 27 Oct 2025 | 4,375 | 36,819 (0%) | 0% | 10 | 43,750 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 58.22 per share. | 21 Oct 2025 | 2,105 | 140,610 (0%) | 0% | 58.2 | 122,553 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 21 Oct 2025 | 2,105 | 142,715 (0%) | 0% | 10.6 | 22,313 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Oct 2025 | 2,105 | 1,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 60.03 per share. | 16 Oct 2025 | 5,000 | 363,108 (0%) | 0% | 60.0 | 300,150 | Common Stock |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 62.80 per share. | 15 Oct 2025 | 338 | 74,578 (0%) | 0% | 62.8 | 21,226 | Common Stock |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 62.80 per share. | 15 Oct 2025 | 99 | 30,873 (0%) | 0% | 62.8 | 6,217 | Common Stock |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 62.80 per share. | 15 Oct 2025 | 199 | 9,977 (0%) | 0% | 62.8 | 12,497 | Common Stock |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 62.80 per share. | 15 Oct 2025 | 199 | 20,692 (0%) | 0% | 62.8 | 12,497 | Common Stock |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 62.80 per share. | 15 Oct 2025 | 99 | 32,444 (0%) | 0% | 62.8 | 6,217 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Oct 2025 | 2,000 | 3,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 60.56 per share. | 07 Oct 2025 | 2,000 | 140,610 (0%) | 0% | 60.6 | 121,120 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 07 Oct 2025 | 2,000 | 142,610 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| Edward M. Kaye | Director | Sale of securities on an exchange or to another person at price $ 60.00 per share. | 06 Oct 2025 | 6,757 | 9,778 (0%) | 0% | 60 | 405,420 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 55.05 per share. | 01 Oct 2025 | 5,000 | 368,108 (0%) | 0% | 55.1 | 275,250 | Common Stock |
| Edward M. Kaye | Director | Sale of securities on an exchange or to another person at price $ 55.08 per share. | 30 Sep 2025 | 6,695 | 16,535 (0%) | 0% | 55.1 | 368,761 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 23 Sep 2025 | 2,000 | 142,610 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Sep 2025 | 2,000 | 5,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 49.28 per share. | 23 Sep 2025 | 2,000 | 140,610 (0%) | 0% | 49.3 | 98,560 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 49.77 per share. | 15 Sep 2025 | 5,000 | 373,108 (0%) | 0% | 49.8 | 248,850 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Sep 2025 | 2,000 | 7,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 51.29 per share. | 09 Sep 2025 | 2,000 | 140,610 (0%) | 0% | 51.3 | 102,580 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 09 Sep 2025 | 2,000 | 142,610 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 48.76 per share. | 02 Sep 2025 | 5,000 | 378,108 (0%) | 0% | 48.8 | 243,800 | Common Stock |
| Edward M. Kaye | Director | Sale of securities on an exchange or to another person at price $ 50.00 per share. | 02 Sep 2025 | 6,756 | 23,230 (0%) | 0% | 50 | 337,800 | Common Stock |
| Robert A. Harrington | Director | Sale of securities on an exchange or to another person at price $ 48.67 per share. | 02 Sep 2025 | 2,150 | 20,493 (0%) | 0% | 48.7 | 104,641 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 19 Aug 2025 | 2,000 | 142,610 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Aug 2025 | 2,000 | 9,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 38.31 per share. | 19 Aug 2025 | 2,000 | 140,610 (0%) | 0% | 38.3 | 76,620 | Common Stock |
| James M. Daly | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Aug 2025 | 27,450 | 27,450 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 38.42 per share. | 15 Aug 2025 | 5,000 | 383,108 (0%) | 0% | 38.4 | 192,100 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Aug 2025 | 2,000 | 11,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 36.34 per share. | 05 Aug 2025 | 2,000 | 140,610 (0%) | 0% | 36.3 | 72,680 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 05 Aug 2025 | 2,000 | 142,610 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 36.45 per share. | 29 Jul 2025 | 5,000 | 388,108 (0%) | 0% | 36.5 | 182,250 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Jul 2025 | 2,000 | 13,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 37.47 per share. | 22 Jul 2025 | 2,000 | 140,610 (0%) | 0% | 37.5 | 74,940 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 22 Jul 2025 | 2,000 | 142,610 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 38.01 per share. | 15 Jul 2025 | 559 | 74,240 (0%) | 0% | 38.0 | 21,248 | Common Stock |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 38.01 per share. | 15 Jul 2025 | 164 | 30,774 (0%) | 0% | 38.0 | 6,234 | Common Stock |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 38.01 per share. | 15 Jul 2025 | 164 | 32,345 (0%) | 0% | 38.0 | 6,234 | Common Stock |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 38.01 per share. | 15 Jul 2025 | 328 | 29,986 (0%) | 0% | 38.0 | 12,467 | Common Stock |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 38.01 per share. | 15 Jul 2025 | 328 | 22,643 (0%) | 0% | 38.0 | 12,467 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 38.15 per share. | 14 Jul 2025 | 5,000 | 393,108 (0%) | 0% | 38.2 | 190,750 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jul 2025 | 2,000 | 15,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 33.76 per share. | 08 Jul 2025 | 2,000 | 140,610 (0%) | 0% | 33.8 | 67,520 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 08 Jul 2025 | 2,000 | 142,610 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 33.55 per share. | 01 Jul 2025 | 5,000 | 398,108 (0%) | 0% | 33.6 | 167,750 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jun 2025 | 2,000 | 17,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 32.91 per share. | 17 Jun 2025 | 2,000 | 140,610 (0%) | 0% | 32.9 | 65,820 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 17 Jun 2025 | 2,000 | 142,610 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 33.80 per share. | 16 Jun 2025 | 5,000 | 403,108 (0%) | 0% | 33.8 | 169,000 | Common Stock |
| Edward M. Kaye | Director | Sale of securities on an exchange or to another person at price $ 32.10 per share. | 05 Jun 2025 | 3,636 | 29,658 (0%) | 0% | 32.1 | 116,716 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 32.04 per share. | 05 Jun 2025 | 8,659 | 52,028 (0%) | 0% | 32.0 | 277,434 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 03 Jun 2025 | 2,000 | 142,610 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jun 2025 | 2,000 | 19,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 31.88 per share. | 03 Jun 2025 | 2,000 | 140,610 (0%) | 0% | 31.9 | 63,760 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 31.22 per share. | 02 Jun 2025 | 5,000 | 408,108 (0%) | 0% | 31.2 | 156,100 | Common Stock |
| Sung H. Lee | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 31.21 per share. | 02 Jun 2025 | 4,965 | 69,477 (0%) | 0% | 31.2 | 154,958 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 20 May 2025 | 2,000 | 142,255 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 31.98 per share. | 20 May 2025 | 2,000 | 140,255 (0%) | 0% | 32.0 | 63,960 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 May 2025 | 2,000 | 21,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 30.93 per share. | 16 May 2025 | 5,000 | 412,629 (0%) | 0% | 30.9 | 154,650 | Common Stock |
| Muna Bhanji | Director | Sale of securities on an exchange or to another person at price $ 29.73 per share. | 15 May 2025 | 1,454 | 23,510 (0%) | 0% | 29.7 | 43,227 | Common Stock |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2025 | 7,333 | 73,681 (0%) | 0% | 0 | Common Stock | |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2025 | 10,880 | 10,880 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2025 | 7,333 | 30,610 (0%) | 0% | 0 | Common Stock | |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2025 | 10,880 | 10,880 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2025 | 10,880 | 10,880 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2025 | 7,333 | 32,181 (0%) | 0% | 0 | Common Stock | |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2025 | 10,880 | 10,880 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2025 | 7,333 | 33,294 (0%) | 0% | 0 | Common Stock | |
| Robert E. Landry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2025 | 7,333 | 7,333 (0%) | 0% | 0 | Common Stock | |
| Robert E. Landry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2025 | 10,880 | 10,880 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Muna Bhanji | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2025 | 10,880 | 10,880 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Muna Bhanji | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2025 | 7,333 | 24,964 (0%) | 0% | 0 | Common Stock | |
| B. Lynne Parshall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2025 | 7,333 | 27,933 (0%) | 0% | 0 | Common Stock | |
| B. Lynne Parshall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2025 | 10,880 | 10,880 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2025 | 7,333 | 22,315 (0%) | 0% | 0 | Common Stock | |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2025 | 10,880 | 10,880 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 35.01 per share. | 06 May 2025 | 2,000 | 140,255 (0%) | 0% | 35.0 | 70,020 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 May 2025 | 2,000 | 23,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 06 May 2025 | 2,000 | 142,255 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 36.68 per share. | 05 May 2025 | 4,002 | 60,687 (0%) | 0% | 36.7 | 146,793 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 40.96 per share. | 29 Apr 2025 | 5,000 | 417,629 (0%) | 0% | 41.0 | 204,800 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Apr 2025 | 2,000 | 25,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 38.11 per share. | 22 Apr 2025 | 2,000 | 140,255 (0%) | 0% | 38.1 | 76,220 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 22 Apr 2025 | 2,000 | 142,255 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.21 per share. | 21 Apr 2025 | 20,000 | 44,848 (0%) | 0% | 6.2 | 124,200 | Common Stock |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Apr 2025 | 20,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Wendell D. Wierenga | Director | Sale of securities on an exchange or to another person at price $ 38.46 per share. | 21 Apr 2025 | 20,000 | 24,848 (0%) | 0% | 38.5 | 769,200 | Common Stock |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 38.56 per share. | 15 Apr 2025 | 551 | 66,348 (0%) | 0% | 38.6 | 21,247 | Common Stock |
| John T. Henderson | Director | Sale of securities on an exchange or to another person at price $ 38.66 per share. | 15 Apr 2025 | 3,190 | 66,348 (0%) | 0% | 38.7 | 123,325 | Common Stock |
| John T. Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2025 | 20,000 | 0 | - | - | Stock Option (Right to Buy) | |
| John T. Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.21 per share. | 15 Apr 2025 | 20,000 | 69,538 (0%) | 0% | 6.2 | 124,200 | Common Stock |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 38.56 per share. | 15 Apr 2025 | 162 | 23,277 (0%) | 0% | 38.6 | 6,247 | Common Stock |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 38.56 per share. | 15 Apr 2025 | 162 | 24,848 (0%) | 0% | 38.6 | 6,247 | Common Stock |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 38.56 per share. | 15 Apr 2025 | 324 | 25,961 (0%) | 0% | 38.6 | 12,493 | Common Stock |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 38.56 per share. | 15 Apr 2025 | 324 | 14,982 (0%) | 0% | 38.6 | 12,493 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 36.77 per share. | 10 Apr 2025 | 5,000 | 422,629 (0%) | 0% | 36.8 | 183,850 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Apr 2025 | 2,000 | 27,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 36.18 per share. | 08 Apr 2025 | 2,000 | 140,255 (0%) | 0% | 36.2 | 72,360 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 08 Apr 2025 | 2,000 | 142,255 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 35.78 per share. | 07 Apr 2025 | 2,886 | 64,689 (0%) | 0% | 35.8 | 103,261 | Common Stock |
| Robert A. Harrington | Director | Sale of securities on an exchange or to another person at price $ 39.43 per share. | 03 Apr 2025 | 450 | 14,658 (0%) | 0% | 39.4 | 17,744 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 40.75 per share. | 31 Mar 2025 | 15,000 | 427,629 (0%) | 0% | 40.8 | 611,250 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Gift of securities by or to the insider at price $ 0.00 per share. | 19 Mar 2025 | 200 | 140,255 (0%) | 0% | 0 | Common Stock | |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Mar 2025 | 2,000 | 29,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 18 Mar 2025 | 2,000 | 142,455 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 43.58 per share. | 18 Mar 2025 | 2,000 | 140,455 (0%) | 0% | 43.6 | 87,160 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 44.65 per share. | 17 Mar 2025 | 25,000 | 339,181 (0%) | 0% | 44.7 | 1,116,250 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 44.38 per share. | 17 Mar 2025 | 12,648 | 326,533 (0%) | 0% | 44.4 | 561,318 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 44.38 per share. | 17 Mar 2025 | 4,389 | 101,005 (0%) | 0% | 44.4 | 194,784 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.26 per share. | 17 Mar 2025 | 20,900 | 58,563 (0%) | 0% | 23.3 | 486,134 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 44.38 per share. | 17 Mar 2025 | 2,775 | 34,888 (0%) | 0% | 44.4 | 123,155 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Mar 2025 | 20,900 | 129,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 45.14 per share. | 17 Mar 2025 | 20,900 | 37,663 (0%) | 0% | 45.1 | 943,426 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Mar 2025 | 100 | 149,900 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 14 Mar 2025 | 100 | 37,663 (0%) | 0% | 45 | 4,500 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.26 per share. | 14 Mar 2025 | 100 | 37,763 (0%) | 0% | 23.3 | 2,326 | Common Stock |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 116,096 | 480,277 (0%) | 0% | 0 | Common Stock | |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 176,547 | 176,547 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 2,254 | 2,254 | - | - | Incentive Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 2,293 | 2,293 | - | - | Incentive Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 58,465 | 58,465 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 39,450 | 144,844 (0%) | 0% | 0 | Common Stock | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 47,593 | 47,593 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 2,749 | 2,749 | - | - | Incentive Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 32,687 | 70,350 (0%) | 0% | 0 | Common Stock | |
| Sung H. Lee | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 41,326 | 41,326 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Sung H. Lee | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 32,687 | 74,442 (0%) | 0% | 0 | Common Stock | |
| Sung H. Lee | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 9,016 | 9,016 | - | - | Incentive Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 43.62 per share. | 13 Mar 2025 | 26,771 | 37,663 (0%) | 0% | 43.6 | 1,167,751 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 43.44 per share. | 06 Mar 2025 | 16,970 | 364,181 (0%) | 0% | 43.4 | 737,177 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 43.27 per share. | 06 Mar 2025 | 8,228 | 105,394 (0%) | 0% | 43.3 | 356,026 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 43.27 per share. | 06 Mar 2025 | 3,341 | 64,434 (0%) | 0% | 43.3 | 144,565 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 43.23 per share. | 05 Mar 2025 | 25,000 | 381,151 (0%) | 0% | 43.2 | 1,080,750 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2025 | 2,000 | 31,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 42.50 per share. | 04 Mar 2025 | 2,000 | 116,071 (0%) | 0% | 42.5 | 85,000 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 04 Mar 2025 | 2,000 | 118,071 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| Robert A. Harrington | Director | Sale of securities on an exchange or to another person at price $ 42.50 per share. | 04 Mar 2025 | 900 | 15,108 (0%) | 0% | 42.5 | 38,250 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 42.88 per share. | 03 Mar 2025 | 8,743 | 406,151 (0%) | 0% | 42.9 | 374,900 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 42.88 per share. | 03 Mar 2025 | 2,449 | 113,622 (0%) | 0% | 42.9 | 105,013 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 42.88 per share. | 03 Mar 2025 | 1,114 | 67,775 (0%) | 0% | 42.9 | 47,768 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 18 Feb 2025 | 2,000 | 118,071 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 45.98 per share. | 18 Feb 2025 | 2,000 | 116,071 (0%) | 0% | 46.0 | 91,960 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2025 | 2,000 | 33,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert E. Landry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2025 | 25,538 | 25,538 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 04 Feb 2025 | 2,000 | 118,071 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Feb 2025 | 2,000 | 35,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 48.06 per share. | 04 Feb 2025 | 2,000 | 116,071 (0%) | 0% | 48.1 | 96,120 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 21 Jan 2025 | 2,000 | 118,071 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jan 2025 | 2,000 | 37,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 45.92 per share. | 21 Jan 2025 | 2,000 | 116,071 (0%) | 0% | 45.9 | 91,840 | Common Stock |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 48.93 per share. | 02 Jan 2025 | 434 | 48,987 (0%) | 0% | 48.9 | 21,236 | Common Stock |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 48.93 per share. | 02 Jan 2025 | 127 | 23,115 (0%) | 0% | 48.9 | 6,214 | Common Stock |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 48.93 per share. | 02 Jan 2025 | 127 | 24,686 (0%) | 0% | 48.9 | 6,214 | Common Stock |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 48.93 per share. | 02 Jan 2025 | 255 | 25,637 (0%) | 0% | 48.9 | 12,477 | Common Stock |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 48.93 per share. | 02 Jan 2025 | 255 | 16,008 (0%) | 0% | 48.9 | 12,477 | Common Stock |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.37 per share. | 16 Dec 2024 | 742 | 25,301 (0%) | 0% | 7.4 | 5,469 | Common Stock |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Dec 2024 | 742 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Wendell D. Wierenga | Director | Sale of securities on an exchange or to another person at price $ 48.61 per share. | 16 Dec 2024 | 742 | 24,559 (0%) | 0% | 48.6 | 36,069 | Common Stock |
| John T. Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.37 per share. | 11 Dec 2024 | 1,780 | 40,241 (0%) | 0% | 7.4 | 13,119 | Common Stock |
| John T. Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Dec 2024 | 1,780 | 10,092 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| John T. Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.37 per share. | 11 Dec 2024 | 10,092 | 48,553 (0%) | 0% | 7.4 | 74,378 | Common Stock |
| John T. Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Dec 2024 | 10,092 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| John T. Henderson | Director | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 11 Dec 2024 | 1,780 | 38,461 (0%) | 0% | 50.4 | 89,748 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 10 Dec 2024 | 5,300 | 123,371 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2024 | 5,300 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 50.65 per share. | 10 Dec 2024 | 2,000 | 116,071 (0%) | 0% | 50.7 | 101,300 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 50.63 per share. | 10 Dec 2024 | 5,300 | 118,071 (0%) | 0% | 50.6 | 268,339 | Common Stock |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Dec 2024 | 11,529 | 409,207 (0%) | 0% | 0 | Common Stock | |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Dec 2024 | 11,530 | 414,894 (0%) | 0% | 0 | Common Stock | |
| Robert I. Blum | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 51.51 per share. | 03 Dec 2024 | 5,843 | 403,364 (0%) | 0% | 51.5 | 300,973 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Dec 2024 | 4,000 | 118,071 (0%) | 0% | 0 | Common Stock | |
| Fady Ibraham Malik | EVP Research & Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 51.51 per share. | 03 Dec 2024 | 2,028 | 114,071 (0%) | 0% | 51.5 | 104,462 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Dec 2024 | 4,000 | 116,099 (0%) | 0% | 0 | Common Stock | |
| Robert C. Wong | VP, Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 51.51 per share. | 03 Dec 2024 | 273 | 17,889 (0%) | 0% | 51.5 | 14,062 | Common Stock |
| Robert C. Wong | VP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Dec 2024 | 766 | 18,655 (0%) | 0% | 0 | Common Stock | |
| Robert C. Wong | VP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Dec 2024 | 764 | 18,162 (0%) | 0% | 0 | Common Stock | |
| Sung H. Lee | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 51.51 per share. | 03 Dec 2024 | 1,536 | 37,451 (0%) | 0% | 51.5 | 79,119 | Common Stock |
| Sung H. Lee | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Dec 2024 | 4,303 | 38,987 (0%) | 0% | 0 | Common Stock | |
| Sung H. Lee | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Dec 2024 | 4,304 | 41,755 (0%) | 0% | 0 | Common Stock | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 51.51 per share. | 03 Dec 2024 | 1,351 | 65,712 (0%) | 0% | 51.5 | 69,590 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Dec 2024 | 3,177 | 68,889 (0%) | 0% | 0 | Common Stock | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Dec 2024 | 3,176 | 67,063 (0%) | 0% | 0 | Common Stock | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 50.76 per share. | 02 Dec 2024 | 5,000 | 397,678 (0%) | 0% | 50.8 | 253,800 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Dec 2024 | 5,000 | 54,727 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 02 Dec 2024 | 5,000 | 402,678 (0%) | 0% | 6.7 | 33,350 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 50.17 per share. | 26 Nov 2024 | 5,300 | 113,878 (0%) | 0% | 50.2 | 265,901 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Nov 2024 | 5,300 | 5,300 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 50.14 per share. | 26 Nov 2024 | 2,000 | 111,878 (0%) | 0% | 50.1 | 100,280 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 26 Nov 2024 | 5,300 | 119,178 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Wendell D. Wierenga | Director | Sale of securities on an exchange or to another person at price $ 50.00 per share. | 25 Nov 2024 | 742 | 24,559 (0%) | 0% | 50 | 37,100 | Common Stock |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Nov 2024 | 742 | 742 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.37 per share. | 25 Nov 2024 | 742 | 25,301 (0%) | 0% | 7.4 | 5,469 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 18 Nov 2024 | 5,000 | 402,456 (0%) | 0% | 6.7 | 33,350 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Nov 2024 | 5,000 | 59,727 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 50.55 per share. | 18 Nov 2024 | 5,000 | 397,456 (0%) | 0% | 50.6 | 252,750 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Nov 2024 | 5,300 | 10,600 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 58.48 per share. | 12 Nov 2024 | 5,300 | 114,920 (0%) | 0% | 58.5 | 309,944 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 58.48 per share. | 12 Nov 2024 | 1,042 | 113,878 (0%) | 0% | 58.5 | 60,936 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 12 Nov 2024 | 5,300 | 120,220 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 01 Nov 2024 | 5,000 | 402,456 (0%) | 0% | 6.7 | 33,350 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2024 | 5,000 | 64,727 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 51.63 per share. | 01 Nov 2024 | 5,000 | 397,456 (0%) | 0% | 51.6 | 258,150 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 51.90 per share. | 30 Oct 2024 | 5,300 | 116,920 (0%) | 0% | 51.9 | 275,070 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 5,300 | 15,900 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 51.93 per share. | 30 Oct 2024 | 2,000 | 114,920 (0%) | 0% | 51.9 | 103,860 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 30 Oct 2024 | 5,300 | 122,220 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Wendell D. Wierenga | Director | Sale of securities on an exchange or to another person at price $ 52.25 per share. | 28 Oct 2024 | 4,452 | 24,559 (0%) | 0% | 52.3 | 232,617 | Common Stock |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Oct 2024 | 4,452 | 1,484 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.37 per share. | 28 Oct 2024 | 4,452 | 29,011 (0%) | 0% | 7.4 | 32,811 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 54.18 per share. | 15 Oct 2024 | 5,300 | 118,920 (0%) | 0% | 54.2 | 287,154 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2024 | 5,300 | 21,200 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 54.20 per share. | 15 Oct 2024 | 2,000 | 116,920 (0%) | 0% | 54.2 | 108,400 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 15 Oct 2024 | 5,300 | 124,220 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 09 Oct 2024 | 5,000 | 402,456 (0%) | 0% | 6.7 | 33,350 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Oct 2024 | 5,000 | 69,727 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 55.61 per share. | 09 Oct 2024 | 5,000 | 397,456 (0%) | 0% | 55.6 | 278,050 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2024 | 5,300 | 26,500 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 52.09 per share. | 01 Oct 2024 | 5,300 | 118,920 (0%) | 0% | 52.1 | 276,077 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 01 Oct 2024 | 5,300 | 124,220 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 52.11 per share. | 01 Oct 2024 | 2,000 | 118,920 (0%) | 0% | 52.1 | 104,220 | Common Stock |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 52.60 per share. | 01 Oct 2024 | 403 | 38,461 (0%) | 0% | 52.6 | 21,198 | Common Stock |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 52.60 per share. | 01 Oct 2024 | 118 | 22,988 (0%) | 0% | 52.6 | 6,207 | Common Stock |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 52.60 per share. | 01 Oct 2024 | 118 | 24,559 (0%) | 0% | 52.6 | 6,207 | Common Stock |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 52.60 per share. | 01 Oct 2024 | 237 | 25,382 (0%) | 0% | 52.6 | 12,466 | Common Stock |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 52.60 per share. | 01 Oct 2024 | 237 | 15,753 (0%) | 0% | 52.6 | 12,466 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 30 Sep 2024 | 5,000 | 402,456 (0%) | 0% | 6.7 | 33,350 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Sep 2024 | 5,000 | 74,727 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 52.14 per share. | 30 Sep 2024 | 5,000 | 397,456 (0%) | 0% | 52.1 | 260,700 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Sep 2024 | 5,300 | 31,800 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 56.76 per share. | 17 Sep 2024 | 2,000 | 120,920 (0%) | 0% | 56.8 | 113,520 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 56.77 per share. | 17 Sep 2024 | 5,300 | 122,920 (0%) | 0% | 56.8 | 300,881 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 17 Sep 2024 | 5,300 | 128,220 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 16 Sep 2024 | 5,000 | 402,456 (0%) | 0% | 6.7 | 33,350 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 55.99 per share. | 16 Sep 2024 | 5,000 | 397,456 (0%) | 0% | 56.0 | 279,950 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Sep 2024 | 5,000 | 79,727 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.61 per share. | 09 Sep 2024 | 5,000 | 25,600 (0%) | 0% | 21.6 | 108,050 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Sep 2024 | 5,000 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 54.92 per share. | 09 Sep 2024 | 5,000 | 20,600 (0%) | 0% | 54.9 | 274,600 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 03 Sep 2024 | 5,000 | 402,456 (0%) | 0% | 6.7 | 33,350 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2024 | 5,000 | 84,727 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 57.03 per share. | 03 Sep 2024 | 5,000 | 397,456 (0%) | 0% | 57.0 | 285,150 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2024 | 5,300 | 37,100 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 57.02 per share. | 03 Sep 2024 | 5,300 | 122,920 (0%) | 0% | 57.0 | 302,206 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 56.99 per share. | 03 Sep 2024 | 2,084 | 122,920 (0%) | 0% | 57.0 | 118,767 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 03 Sep 2024 | 5,300 | 128,220 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Brett A. Pletcher | EVP, Chief Legal Officer | 30 Aug 2024 | 51,039 | 51,039 | - | - | Non-Qualified Stock Option (Right to Buy) | ||
| Brett A. Pletcher | EVP, Chief Legal Officer | 30 Aug 2024 | 33,140 | 33,140 (0%) | 0% | 0 | Common Stock | ||
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.61 per share. | 26 Aug 2024 | 5,000 | 25,600 (0%) | 0% | 21.6 | 108,050 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Aug 2024 | 5,000 | 5,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 57.26 per share. | 26 Aug 2024 | 5,000 | 20,600 (0%) | 0% | 57.3 | 286,300 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 20 Aug 2024 | 5,300 | 130,304 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Aug 2024 | 5,300 | 42,400 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 56.26 per share. | 20 Aug 2024 | 5,300 | 125,004 (0%) | 0% | 56.3 | 298,178 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 56.23 per share. | 20 Aug 2024 | 2,000 | 125,004 (0%) | 0% | 56.2 | 112,460 | Common Stock |
| Robert I. Blum | Director, President & CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 19 Aug 2024 | 1,956 | 397,456 (0%) | 0% | 0 | Common Stock | |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 55.20 per share. | 12 Aug 2024 | 5,000 | 20,600 (0%) | 0% | 55.2 | 276,000 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.61 per share. | 12 Aug 2024 | 5,000 | 25,600 (0%) | 0% | 21.6 | 108,050 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2024 | 5,000 | 10,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 12 Aug 2024 | 11,500 | 410,912 (0%) | 0% | 6.7 | 76,705 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 55.17 per share. | 12 Aug 2024 | 11,500 | 399,412 (0%) | 0% | 55.2 | 634,455 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2024 | 11,500 | 89,727 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 06 Aug 2024 | 5,300 | 127,004 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2024 | 5,300 | 47,700 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 53.70 per share. | 06 Aug 2024 | 5,300 | 123,704 (0%) | 0% | 53.7 | 284,610 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 53.74 per share. | 06 Aug 2024 | 2,000 | 121,704 (0%) | 0% | 53.7 | 107,480 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 59.49 per share. | 30 Jul 2024 | 11,500 | 399,412 (0%) | 0% | 59.5 | 684,135 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 30 Jul 2024 | 11,500 | 410,912 (0%) | 0% | 6.7 | 76,705 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2024 | 11,500 | 101,227 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 59.84 per share. | 29 Jul 2024 | 5,000 | 20,600 (0%) | 0% | 59.8 | 299,200 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Jul 2024 | 5,000 | 15,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.61 per share. | 29 Jul 2024 | 5,000 | 25,600 (0%) | 0% | 21.6 | 108,050 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 23 Jul 2024 | 5,300 | 134,304 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jul 2024 | 5,300 | 53,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 57.02 per share. | 23 Jul 2024 | 5,300 | 129,004 (0%) | 0% | 57.0 | 302,206 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 57.02 per share. | 23 Jul 2024 | 2,000 | 129,004 (0%) | 0% | 57.0 | 114,040 | Common Stock |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 55.82 per share. | 15 Jul 2024 | 5,000 | 20,600 (0%) | 0% | 55.8 | 279,100 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.68 per share. | 15 Jul 2024 | 5,000 | 25,600 (0%) | 0% | 10.7 | 53,400 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 5,000 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 10 Jul 2024 | 5,767 | 410,912 (0%) | 0% | 6.7 | 38,466 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jul 2024 | 5,767 | 112,727 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 54.29 per share. | 10 Jul 2024 | 11,500 | 399,412 (0%) | 0% | 54.3 | 624,335 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jul 2024 | 5,300 | 58,300 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 55.89 per share. | 09 Jul 2024 | 2,000 | 131,004 (0%) | 0% | 55.9 | 111,780 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 55.91 per share. | 09 Jul 2024 | 5,300 | 133,004 (0%) | 0% | 55.9 | 296,323 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 09 Jul 2024 | 5,300 | 138,304 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Robert A. Harrington | Director | Sale of securities on an exchange or to another person at price $ 54.61 per share. | 05 Jul 2024 | 253 | 15,516 (0%) | 0% | 54.6 | 13,816 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2024 | 5,000 | 5,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 54.22 per share. | 01 Jul 2024 | 5,000 | 20,600 (0%) | 0% | 54.2 | 271,100 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.68 per share. | 01 Jul 2024 | 5,000 | 25,600 (0%) | 0% | 10.7 | 53,400 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 54.05 per share. | 01 Jul 2024 | 11,500 | 405,145 (0%) | 0% | 54.1 | 621,575 | Common Stock |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 388 | 38,058 (0%) | 0% | 0 | Common Stock | |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 114 | 22,870 (0%) | 0% | 0 | Common Stock | |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 114 | 24,441 (0%) | 0% | 0 | Common Stock | |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 228 | 25,145 (0%) | 0% | 0 | Common Stock | |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 228 | 15,769 (0%) | 0% | 0 | Common Stock | |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 25 Jun 2024 | 5,300 | 138,304 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 53.71 per share. | 25 Jun 2024 | 5,300 | 133,004 (0%) | 0% | 53.7 | 284,663 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2024 | 5,300 | 63,600 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 53.74 per share. | 25 Jun 2024 | 2,000 | 133,004 (0%) | 0% | 53.7 | 107,480 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.68 per share. | 17 Jun 2024 | 5,000 | 25,600 (0%) | 0% | 10.7 | 53,400 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jun 2024 | 5,000 | 10,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 52.55 per share. | 17 Jun 2024 | 5,000 | 20,600 (0%) | 0% | 52.6 | 262,750 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 52.60 per share. | 17 Jun 2024 | 11,551 | 427,594 (0%) | 0% | 52.6 | 607,583 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 52.59 per share. | 17 Jun 2024 | 10,949 | 416,645 (0%) | 0% | 52.6 | 575,808 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Jun 2024 | 5,422 | 68,900 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 53.03 per share. | 11 Jun 2024 | 2,366 | 135,004 (0%) | 0% | 53.0 | 125,469 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 53.05 per share. | 11 Jun 2024 | 5,422 | 137,370 (0%) | 0% | 53.0 | 287,637 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 11 Jun 2024 | 5,422 | 142,792 (0%) | 0% | 8.0 | 43,159 | Common Stock |
| Muna Bhanji | Director | Sale of securities on an exchange or to another person at price $ 52.07 per share. | 10 Jun 2024 | 2,000 | 17,631 (0%) | 0% | 52.1 | 104,140 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 48.85 per share. | 04 Jun 2024 | 22,500 | 439,145 (0%) | 0% | 48.9 | 1,099,125 | Common Stock |
| Robert C. Wong | VP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 48.88 per share. | 03 Jun 2024 | 13,011 | 16,653 (0%) | 0% | 48.9 | 635,978 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jun 2024 | 5,000 | 15,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 48.64 per share. | 03 Jun 2024 | 5,000 | 15,600 (0%) | 0% | 48.6 | 243,200 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.68 per share. | 03 Jun 2024 | 5,000 | 20,600 (0%) | 0% | 10.7 | 53,400 | Common Stock |
| Robert A. Harrington | Director | Sale of securities on an exchange or to another person at price $ 48.64 per share. | 03 Jun 2024 | 1,580 | 15,541 (0%) | 0% | 48.6 | 76,851 | Common Stock |
| Sung H. Lee | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 53,417 | 53,417 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Sung H. Lee | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 34,684 | 34,684 (0%) | 0% | 0 | Common Stock | |
| B. Lynne Parshall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 3,636 | 3,636 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| B. Lynne Parshall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 5,600 | 20,600 (0%) | 0% | 0 | Common Stock | |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 5,600 | 37,670 (0%) | 0% | 0 | Common Stock | |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 3,636 | 3,636 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 3,636 | 3,636 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 5,600 | 22,756 (0%) | 0% | 0 | Common Stock | |
| Santo J. Costa | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 3,636 | 3,636 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Santo J. Costa | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 5,600 | 20,600 (0%) | 0% | 0 | Common Stock | |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 3,636 | 3,636 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 5,600 | 24,327 (0%) | 0% | 0 | Common Stock | |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 3,636 | 3,636 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 5,600 | 24,917 (0%) | 0% | 0 | Common Stock | |
| Muna Bhanji | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 5,600 | 19,631 (0%) | 0% | 0 | Common Stock | |
| Muna Bhanji | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 3,636 | 3,636 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 5,600 | 17,121 (0%) | 0% | 0 | Common Stock | |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 3,636 | 3,636 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 65.11 per share. | 07 May 2024 | 14,186 | 138,417 (0%) | 0% | 65.1 | 923,650 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 65.11 per share. | 07 May 2024 | 1,361 | 137,056 (0%) | 0% | 65.1 | 88,615 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 May 2024 | 14,186 | 0 | - | - | Incentive Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 07 May 2024 | 14,186 | 152,603 (0%) | 0% | 6.7 | 94,621 | Common Stock |
| John T. Henderson | Director | Sale of securities on an exchange or to another person at price $ 64.54 per share. | 25 Apr 2024 | 10,562 | 32,070 (0%) | 0% | 64.5 | 681,671 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Gift of securities by or to the insider at price $ 0.00 per share. | 12 Apr 2024 | 150 | 138,417 (0%) | 0% | 0 | Common Stock | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 74.31 per share. | 09 Apr 2024 | 28,605 | 142,567 (0%) | 0% | 74.3 | 2,125,638 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 09 Apr 2024 | 28,605 | 171,172 (0%) | 0% | 6.7 | 190,795 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Apr 2024 | 28,605 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 74.32 per share. | 09 Apr 2024 | 4,000 | 138,567 (0%) | 0% | 74.3 | 297,280 | Common Stock |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 61,490 | 461,221 (0%) | 0% | 0 | Common Stock | |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 69,464 | 69,464 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 1,568 | 1,568 | - | - | Incentive Stock Option (Right to Buy) |