XNAS 05 Sep, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 13.58 per share. | 12 Aug 2025 | 2,937 | 242,346 (0%) | 0% | 13.6 | 39,884 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 14.64 per share. | 12 Aug 2025 | 806 | 216,585 (0%) | 0% | 14.6 | 11,800 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 13.58 per share. | 12 Aug 2025 | 2,937 | 217,391 (0%) | 0% | 13.6 | 39,884 | Common Stock |
| Carole Ho | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.68 per share. | 05 Aug 2025 | 44,655 | 220,328 (0%) | 0% | 0.7 | 30,365 | Common Stock |
| Carole Ho | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Aug 2025 | 44,655 | 62,500 | - | - | Stock Option (right to buy) | |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.68 per share. | 09 Jul 2025 | 455,282 | 708,353 (0%) | 0% | 0.7 | 309,592 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jul 2025 | 40,000 | 20,369 | - | - | Stock Option (right to buy) | |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jul 2025 | 455,282 | 622,809 | - | - | Stock Option (right to buy) | |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 15.00 per share. | 09 Jul 2025 | 495,282 | 253,071 (0%) | 0% | 15 | 7,429,230 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.28 per share. | 09 Jul 2025 | 40,000 | 748,353 (0%) | 0% | 5.3 | 211,200 | Common Stock |
| Jay T. Flatley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2025 | 18,111 | 18,111 | - | - | Stock Option (right to buy) | |
| Jay T. Flatley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2025 | 6,037 | 16,220 (0%) | 0% | 0 | Common Stock | |
| Marc Tessier-Lavigne | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2025 | 18,111 | 18,111 | - | - | Stock Option (right to buy) | |
| Marc Tessier-Lavigne | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2025 | 6,037 | 1,886,576 (1%) | 0% | 0 | Common Stock | |
| Peter S. Klein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2025 | 6,037 | 27,533 (0%) | 0% | 0 | Common Stock | |
| Peter S. Klein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2025 | 18,111 | 18,111 | - | - | Stock Option (right to buy) | |
| David P. Schenkein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2025 | 18,111 | 18,111 | - | - | Stock Option (right to buy) | |
| David P. Schenkein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2025 | 6,037 | 15,257 (0%) | 0% | 0 | Common Stock | |
| Steven E. Krognes | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2025 | 18,111 | 18,111 | - | - | Stock Option (right to buy) | |
| Steven E. Krognes | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2025 | 6,037 | 31,794 (0%) | 0% | 0 | Common Stock | |
| Jennifer E. Cook | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2025 | 6,037 | 26,075 (0%) | 0% | 0 | Common Stock | |
| Jennifer E. Cook | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2025 | 18,111 | 18,111 | - | - | Stock Option (right to buy) | |
| Nancy A. Thornberry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2025 | 18,111 | 18,111 | - | - | Stock Option (right to buy) | |
| Nancy A. Thornberry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2025 | 6,037 | 24,717 (0%) | 0% | 0 | Common Stock | |
| Steven E. Krognes | Director | Sale of securities on an exchange or to another person at price $ 20.81 per share. | 07 Jan 2025 | 3,339 | 25,757 (0%) | 0% | 20.8 | 69,485 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 20.81 per share. | 06 Jan 2025 | 7,650 | 253,071 (0%) | 0% | 20.8 | 159,197 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 20.22 per share. | 06 Jan 2025 | 29,266 | 260,721 (0%) | 0% | 20.2 | 591,759 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 20.22 per share. | 06 Jan 2025 | 12,255 | 247,215 (0%) | 0% | 20.2 | 247,796 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 20.81 per share. | 06 Jan 2025 | 2,907 | 244,308 (0%) | 0% | 20.8 | 60,495 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 20.22 per share. | 06 Jan 2025 | 12,255 | 178,580 (0%) | 0% | 20.2 | 247,796 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 20.81 per share. | 06 Jan 2025 | 2,907 | 175,673 (0%) | 0% | 20.8 | 60,495 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2025 | 54,180 | 289,987 (0%) | 0% | 0 | Common Stock | |
| Ryan J. Watts | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2025 | 162,540 | 162,540 | - | - | Stock Option (right to buy) | |
| Alexander O. Schuth | COFO and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2025 | 162,540 | 162,540 | - | - | Stock Option (right to buy) | |
| Alexander O. Schuth | COFO and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2025 | 54,180 | 259,470 (0%) | 0% | 0 | Common Stock | |
| Carole Ho | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2025 | 162,540 | 162,540 | - | - | Stock Option (right to buy) | |
| Carole Ho | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2025 | 54,180 | 190,835 (0%) | 0% | 0 | Common Stock | |
| Vicki L. Sato | Director | Sale of securities on an exchange or to another person at price $ 20.91 per share. | 02 Jan 2025 | 3,080 | 107,976 (0%) | 0% | 20.9 | 64,403 | Common Stock |
| Steven E. Krognes | Director | Sale of securities on an exchange or to another person at price $ 20.25 per share. | 31 Dec 2024 | 30,000 | 29,096 (0%) | 0% | 20.3 | 607,500 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.28 per share. | 27 Dec 2024 | 6,708 | 205,290 (0%) | 0% | 5.3 | 35,418 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Dec 2024 | 6,708 | 46,671 | - | - | Stock Option (right to buy) | |
| Carole Ho | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.68 per share. | 25 Nov 2024 | 17,845 | 136,655 (0%) | 0% | 0.7 | 12,135 | Common Stock |
| Carole Ho | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Nov 2024 | 17,845 | 107,155 | - | - | Stock Option (right to buy) | |
| Alexander O. Schuth | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.68 per share. | 22 Nov 2024 | 20,516 | 198,582 (0%) | 0% | 0.7 | 13,951 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Nov 2024 | 20,516 | 124,562 | - | - | Stock Option (right to buy) | |
| David P. Schenkein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Nov 2024 | 47,165 | 0 | - | - | Stock Option (right to buy) | |
| David P. Schenkein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.00 per share. | 11 Nov 2024 | 47,165 | 68,661 (0%) | 0% | 18 | 848,970 | Common Stock |
| David P. Schenkein | Director | Sale of securities on an exchange or to another person at price $ 32.87 per share. | 11 Nov 2024 | 32,312 | 9,220 (0%) | 0% | 32.9 | 1,062,095 | Common Stock |
| David P. Schenkein | Director | Sale of securities on an exchange or to another person at price $ 32.09 per share. | 11 Nov 2024 | 27,129 | 41,532 (0%) | 0% | 32.1 | 870,570 | Common Stock |
| Vicki L. Sato | Director | 07 Nov 2024 | 1,020 | 111,056 (0%) | 0% | 30 | 30,600 | Common Stock | |
| Alexander O. Schuth | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Nov 2024 | 15,558 | 53,379 | - | - | Stock Option (right to buy) | |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 31.29 per share. | 07 Nov 2024 | 300 | 178,066 (0%) | 0% | 31.3 | 9,387 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 30.72 per share. | 07 Nov 2024 | 2,925 | 178,366 (0%) | 0% | 30.7 | 89,856 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 29.68 per share. | 07 Nov 2024 | 12,333 | 181,291 (0%) | 0% | 29.7 | 366,043 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.28 per share. | 07 Nov 2024 | 15,558 | 193,624 (0%) | 0% | 5.3 | 82,146 | Common Stock |
| Vicki L. Sato | Director | 01 Nov 2024 | 3,080 | 112,076 (0%) | 0% | 27.1 | 83,376 | Common Stock | |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 27.69 per share. | 18 Oct 2024 | 40,000 | 235,807 (0%) | 0% | 27.7 | 1,107,600 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Oct 2024 | 40,000 | 1,078,091 | - | - | Stock Option (right to buy) | |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.68 per share. | 18 Oct 2024 | 40,000 | 275,807 (0%) | 0% | 0.7 | 27,200 | Common Stock |
| Steven E. Krognes | Director | Sale of securities on an exchange or to another person at price $ 29.03 per share. | 30 Sep 2024 | 30,000 | 29,096 (0%) | 0% | 29.0 | 870,900 | Common Stock |
| Vicki L. Sato | Director | 13 Sep 2024 | 1,020 | 115,156 (0%) | 0% | 30 | 30,600 | Common Stock | |
| Vicki L. Sato | Director | 03 Sep 2024 | 2,980 | 116,276 (0%) | 0% | 25.0 | 74,470 | Common Stock | |
| Vicki L. Sato | Director | 03 Sep 2024 | 100 | 116,176 (0%) | 0% | 25.4 | 2,537 | Common Stock | |
| Steven E. Krognes | Director | Sale of securities on an exchange or to another person at price $ 23.79 per share. | 20 Aug 2024 | 1,727 | 32,677 (0%) | 0% | 23.8 | 41,085 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 23.79 per share. | 20 Aug 2024 | 2,260 | 235,807 (0%) | 0% | 23.8 | 53,765 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 23.54 per share. | 20 Aug 2024 | 3,353 | 180,613 (0%) | 0% | 23.5 | 78,930 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 24.78 per share. | 20 Aug 2024 | 2,547 | 178,066 (0%) | 0% | 24.8 | 63,115 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 23.79 per share. | 20 Aug 2024 | 2,453 | 183,966 (0%) | 0% | 23.8 | 58,357 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 24.41 per share. | 20 Aug 2024 | 14,098 | 124,717 (0%) | 0% | 24.4 | 344,132 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 24.96 per share. | 20 Aug 2024 | 5,907 | 118,810 (0%) | 0% | 25.0 | 147,439 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 23.79 per share. | 20 Aug 2024 | 2,453 | 138,815 (0%) | 0% | 23.8 | 58,357 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 22.89 per share. | 13 Aug 2024 | 2,272 | 186,419 (0%) | 0% | 22.9 | 52,006 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 22.89 per share. | 13 Aug 2024 | 2,337 | 141,268 (0%) | 0% | 22.9 | 53,494 | Common Stock |
| Vicki L. Sato | Director | 01 Jul 2024 | 2,980 | 119,356 (0%) | 0% | 22.1 | 65,918 | Common Stock | |
| Vicki L. Sato | Director | 01 Jul 2024 | 100 | 119,256 (0%) | 0% | 22.9 | 2,286 | Common Stock | |
| Steven E. Krognes | Director | Sale of securities on an exchange or to another person at price $ 22.80 per share. | 13 Jun 2024 | 100 | 34,404 (0%) | 0% | 22.8 | 2,280 | Common Stock |
| Steven E. Krognes | Director | Sale of securities on an exchange or to another person at price $ 21.79 per share. | 13 Jun 2024 | 688 | 52,620 (0%) | 0% | 21.8 | 14,992 | Common Stock |
| Steven E. Krognes | Director | Sale of securities on an exchange or to another person at price $ 22.12 per share. | 13 Jun 2024 | 29,900 | 34,504 (0%) | 0% | 22.1 | 661,388 | Common Stock |
| Jennifer E. Cook | Director | Sale of securities on an exchange or to another person at price $ 21.73 per share. | 06 Jun 2024 | 1,458 | 20,038 (0%) | 0% | 21.7 | 31,682 | Common Stock |
| Jay T. Flatley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 5,967 | 10,183 (0%) | 0% | 0 | Common Stock | |
| Jay T. Flatley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 17,901 | 17,901 | - | - | Stock Option (right to buy) | |
| Marc Tessier-Lavigne | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 17,901 | 17,901 | - | - | Stock Option (right to buy) | |
| Marc Tessier-Lavigne | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 5,967 | 1,880,539 (1%) | 0% | 0 | Common Stock | |
| Vicki L. Sato | Director | 31 May 2024 | 5,967 | 122,336 (0%) | 0% | 0 | Common Stock | ||
| Vicki L. Sato | Director | 31 May 2024 | 17,901 | 17,901 | - | - | Stock Option (right to buy) | ||
| Peter S. Klein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 5,967 | 21,496 (0%) | 0% | 0 | Common Stock | |
| Peter S. Klein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 17,901 | 17,901 | - | - | Stock Option (right to buy) | |
| David P. Schenkein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 17,901 | 17,901 | - | - | Stock Option (right to buy) | |
| David P. Schenkein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 5,967 | 21,496 (0%) | 0% | 0 | Common Stock | |
| Steven E. Krognes | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 5,967 | 53,308 (0%) | 0% | 0 | Common Stock | |
| Steven E. Krognes | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 17,901 | 17,901 | - | - | Stock Option (right to buy) | |
| Jennifer E. Cook | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 5,967 | 21,496 (0%) | 0% | 0 | Common Stock | |
| Jennifer E. Cook | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 17,901 | 17,901 | - | - | Stock Option (right to buy) | |
| Erik Harris | Director | 31 May 2024 | 17,901 | 17,901 | - | - | Stock Option (right to buy) | ||
| Erik Harris | Director | 31 May 2024 | 5,967 | 17,052 (0%) | 0% | 0 | Common Stock | ||
| Nancy A. Thornberry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 5,967 | 18,680 (0%) | 0% | 0 | Common Stock | |
| Nancy A. Thornberry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 17,901 | 17,901 | - | - | Stock Option (right to buy) | |
| Vicki L. Sato | Director | 15 May 2024 | 1,674 | 116,369 (0%) | 0% | 20.4 | 34,133 | Common Stock | |
| Vicki L. Sato | Director | 15 Apr 2024 | 1,666 | 118,043 (0%) | 0% | 18.3 | 30,471 | Common Stock | |
| Steve E. Krognes | Director | Sale of securities on an exchange or to another person at price $ 20.50 per share. | 01 Apr 2024 | 92,500 | 47,341 (0%) | 0% | 20.5 | 1,896,250 | Common Stock |
| Vicki L. Sato | Director | 15 Mar 2024 | 1,666 | 119,709 (0%) | 0% | 20.1 | 33,487 | Common Stock | |
| Sato L. Vicki | Director | 15 Feb 2024 | 1,666 | 121,375 (0%) | 0% | 18.4 | 30,604 | Common Stock | |
| Ho Carole | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 17.79 per share. | 13 Feb 2024 | 1,405 | 143,605 (0%) | 0% | 17.8 | 24,995 | Common Stock |
| J. Watts Ryan | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 17.29 per share. | 13 Feb 2024 | 9,589 | 238,067 (0%) | 0% | 17.3 | 165,794 | Common Stock |
| Schuth O. Alexander | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 17.66 per share. | 13 Feb 2024 | 20,128 | 187,341 (0%) | 0% | 17.7 | 355,460 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 17.29 per share. | 13 Feb 2024 | 2,784 | 145,010 (0%) | 0% | 17.3 | 48,135 | Common Stock |
| Schuth Alexander O. | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 17.29 per share. | 13 Feb 2024 | 2,716 | 207,469 (0%) | 0% | 17.3 | 46,960 | Common Stock |
| Krognes E. Steve | Director | Sale of securities on an exchange or to another person at price $ 17.29 per share. | 13 Feb 2024 | 2,750 | 139,841 (0%) | 0% | 17.3 | 47,548 | Common Stock |
| Alexander Schuth O. | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2024 | 50,000 | 145,078 | - | - | Stock Option (right to buy) | |
| Alexander Schuth O. | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.68 per share. | 08 Feb 2024 | 50,000 | 210,185 (0%) | 0% | 0.7 | 34,000 | Common Stock |
| L. Sato Vicki | Director | 16 Jan 2024 | 1,666 | 123,041 (0%) | 0% | 18.4 | 30,688 | Common Stock | |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 19.02 per share. | 10 Jan 2024 | 4,668 | 147,794 (0%) | 0% | 19.0 | 88,785 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 19.78 per share. | 09 Jan 2024 | 7,818 | 2,268,363 (2%) | 0% | 19.8 | 154,640 | Common Stock |
| J. Watts Ryan | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 19.43 per share. | 05 Jan 2024 | 17,483 | 2,276,181 (2%) | 0% | 19.4 | 339,695 | Common Stock |
| Ho Carole | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 19.43 per share. | 05 Jan 2024 | 9,972 | 198,777 (0%) | 0% | 19.4 | 193,756 | Common Stock |
| O. Schuth Alexander | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 19.43 per share. | 05 Jan 2024 | 9,972 | 539,307 (0%) | 0% | 19.4 | 193,756 | Common Stock |
| Krognes E. Steve | Director | Sale of securities on an exchange or to another person at price $ 19.43 per share. | 05 Jan 2024 | 3,208 | 142,591 (0%) | 0% | 19.4 | 62,331 | Common Stock |
| Watts J. Ryan | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2024 | 268,560 | 268,560 | - | - | Stock Option (right to buy) | |
| Ho Carole | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2024 | 161,160 | 161,160 | - | - | Stock Option (right to buy) | |
| J. Ryan Watts | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2024 | 89,520 | 272,957 (0%) | 0% | 0 | Common Stock | |
| O. Alexander Schuth | COFO and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2024 | 161,160 | 161,160 | - | - | Stock Option (right to buy) | |
| Carole Ho | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2024 | 53,720 | 162,434 (0%) | 0% | 0 | Common Stock | |
| Schuth Alexander O. | COFO and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2024 | 53,720 | 170,157 (0%) | 0% | 0 | Common Stock | |
| Vicki L. Sato | Director | 15 Dec 2023 | 1,666 | 124,707 (0%) | 0% | 23.4 | 38,968 | Common Stock | |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 23.17 per share. | 23 Aug 2023 | 2,522 | 518,989 (0%) | 0% | 23.2 | 58,435 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 23.22 per share. | 23 Aug 2023 | 2,522 | 182,809 (0%) | 0% | 23.2 | 58,561 | Common Stock |
| Steve E. Krognes | Director | Sale of securities on an exchange or to another person at price $ 22.60 per share. | 21 Aug 2023 | 1,419 | 145,799 (0%) | 0% | 22.6 | 32,069 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 22.59 per share. | 21 Aug 2023 | 2,309 | 2,242,604 (2%) | 0% | 22.6 | 52,160 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 22.59 per share. | 21 Aug 2023 | 2,478 | 521,511 (0%) | 0% | 22.6 | 55,978 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 22.60 per share. | 21 Aug 2023 | 2,478 | 185,331 (0%) | 0% | 22.6 | 56,003 | Common Stock |
| Vicki L. Sato | Director | 15 Aug 2023 | 1,666 | 131,371 (0%) | 0% | 24.3 | 40,484 | Common Stock | |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 23.67 per share. | 14 Aug 2023 | 2,772 | 518,989 (0%) | 0% | 23.7 | 65,613 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 23.79 per share. | 14 Aug 2023 | 2,768 | 182,809 (0%) | 0% | 23.8 | 65,851 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 25.03 per share. | 10 Aug 2023 | 2,526 | 2,239,913 (2%) | 0% | 25.0 | 63,226 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Aug 2023 | 2,526 | 1,118,091 | - | - | Stock Option (right to buy) | |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.68 per share. | 10 Aug 2023 | 2,526 | 2,242,439 (2%) | 0% | 0.7 | 1,718 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 24.18 per share. | 10 Aug 2023 | 2,853 | 521,761 (0%) | 0% | 24.2 | 68,986 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 24.15 per share. | 10 Aug 2023 | 2,857 | 185,577 (0%) | 0% | 24.2 | 68,997 | Common Stock |
| Vicki L. Sato | Director | 17 Jul 2023 | 1,666 | 133,037 (0%) | 0% | 29.6 | 49,314 | Common Stock | |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 30.01 per share. | 17 Jul 2023 | 9,702 | 518,989 (0%) | 0% | 30.0 | 291,157 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 10,000 | 68,937 | - | - | Stock Option (right to buy) | |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 29.60 per share. | 17 Jul 2023 | 10,000 | 528,691 (0%) | 0% | 29.6 | 296,000 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.28 per share. | 17 Jul 2023 | 10,000 | 538,691 (0%) | 0% | 5.3 | 52,800 | Common Stock |
| Vicki L. Sato | Director | 28 Jun 2023 | 1,114 | 134,703 (0%) | 0% | 30.0 | 33,398 | Common Stock | |
| Vicki L. Sato | Director | 28 Jun 2023 | 552 | 135,817 (0%) | 0% | 29.6 | 16,312 | Common Stock | |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.68 per share. | 16 Jun 2023 | 50,000 | 2,289,913 (2%) | 0% | 0.7 | 34,000 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2023 | 50,000 | 1,120,617 | - | - | Stock Option (right to buy) | |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 31.40 per share. | 16 Jun 2023 | 50,000 | 2,239,913 (2%) | 0% | 31.4 | 1,570,000 | Common Stock |
| Jay T. Flatley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 4,216 | 340,529 (0%) | 0% | 0 | Common Stock | |
| Jay T. Flatley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 12,649 | 12,649 | - | - | Stock Option (right to buy) | |
| Marc Tessier-Lavigne | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 12,649 | 12,649 | - | - | Stock Option (right to buy) | |
| Marc Tessier-Lavigne | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 4,216 | 1,874,572 (1%) | 0% | 0 | Common Stock | |
| Vicki L. Sato | Director | 01 Jun 2023 | 12,649 | 12,649 | - | - | Stock Option (right to buy) | ||
| Vicki L. Sato | Director | 01 Jun 2023 | 4,216 | 136,369 (0%) | 0% | 0 | Common Stock | ||
| Peter S. Klein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 12,649 | 12,649 | - | - | Stock Option (right to buy) | |
| Peter S. Klein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 4,216 | 15,529 (0%) | 0% | 0 | Common Stock | |
| Douglas G. Cole | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 12,649 | 12,649 | - | - | Stock Option (right to buy) | |
| Douglas G. Cole | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 4,216 | 26,564 (0%) | 0% | 0 | Common Stock | |
| David P. Schenkein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 4,216 | 15,529 (0%) | 0% | 0 | Common Stock | |
| David P. Schenkein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 12,649 | 12,649 | - | - | Stock Option (right to buy) | |
| Steve E. Krognes | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 12,649 | 12,649 | - | - | Stock Option (right to buy) | |
| Steve E. Krognes | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 4,216 | 147,218 (0%) | 0% | 0 | Common Stock | |
| Jennifer E. Cook | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 4,216 | 15,529 (0%) | 0% | 0 | Common Stock | |
| Jennifer E. Cook | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 12,649 | 12,649 | - | - | Stock Option (right to buy) | |
| Erik Harris | Director | 01 Jun 2023 | 4,216 | 11,085 (0%) | 0% | 0 | Common Stock | ||
| Erik Harris | Director | 01 Jun 2023 | 12,649 | 12,649 | - | - | Stock Option (right to buy) | ||
| Nancy Thornberry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 4,216 | 12,713 (0%) | 0% | 0 | Common Stock | |
| Nancy Thornberry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 12,649 | 12,649 | - | - | Stock Option (right to buy) | |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 28.55 per share. | 15 May 2023 | 9,200 | 529,491 (0%) | 0% | 28.6 | 262,660 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.28 per share. | 15 May 2023 | 10,000 | 538,691 (0%) | 0% | 5.3 | 52,800 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 29.23 per share. | 15 May 2023 | 800 | 528,691 (0%) | 0% | 29.2 | 23,384 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 May 2023 | 10,000 | 78,937 | - | - | Stock Option (right to buy) | |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.68 per share. | 20 Apr 2023 | 200 | 2,240,113 (2%) | 0% | 0.7 | 136 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Apr 2023 | 24,800 | 1,170,617 | - | - | Stock Option (right to buy) | |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Apr 2023 | 200 | 1,195,417 | - | - | Stock Option (right to buy) | |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 25.15 per share. | 20 Apr 2023 | 24,800 | 2,239,913 (2%) | 0% | 25.2 | 623,720 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.68 per share. | 20 Apr 2023 | 24,800 | 2,264,713 (2%) | 0% | 0.7 | 16,864 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 20 Apr 2023 | 200 | 2,239,913 (2%) | 0% | 25 | 5,000 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 25.04 per share. | 12 Apr 2023 | 5,102 | 528,691 (0%) | 0% | 25.0 | 127,754 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Apr 2023 | 4,898 | 88,937 | - | - | Stock Option (right to buy) | |
| Alexander O. Schuth | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Apr 2023 | 5,102 | 93,835 | - | - | Stock Option (right to buy) | |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 25.04 per share. | 12 Apr 2023 | 4,898 | 528,691 (0%) | 0% | 25.0 | 122,646 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.28 per share. | 12 Apr 2023 | 4,898 | 533,589 (0%) | 0% | 5.3 | 25,861 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.28 per share. | 12 Apr 2023 | 5,102 | 533,793 (0%) | 0% | 5.3 | 26,939 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 29.40 per share. | 15 Feb 2023 | 1,476 | 182,809 (0%) | 0% | 29.4 | 43,394 | Common Stock |
| Steve E. Krognes | Director | Sale of securities on an exchange or to another person at price $ 30.10 per share. | 13 Feb 2023 | 2,119 | 143,002 (0%) | 0% | 30.1 | 63,782 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.68 per share. | 13 Feb 2023 | 25,000 | 2,264,913 (2%) | 0% | 0.7 | 17,000 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Feb 2023 | 25,000 | 1,195,617 | - | - | Stock Option (right to buy) | |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 30.08 per share. | 13 Feb 2023 | 25,000 | 2,239,913 (2%) | 0% | 30.1 | 752,000 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 30.09 per share. | 13 Feb 2023 | 8,815 | 2,239,913 (2%) | 0% | 30.1 | 265,243 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Feb 2023 | 25,000 | 195,078 | - | - | Stock Option (right to buy) | |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 30.09 per share. | 13 Feb 2023 | 3,497 | 528,691 (0%) | 0% | 30.1 | 105,225 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.68 per share. | 13 Feb 2023 | 25,000 | 524,902 (0%) | 0% | 0.7 | 17,000 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 30.10 per share. | 10 Feb 2023 | 2,548 | 184,285 (0%) | 0% | 30.1 | 76,695 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 29.80 per share. | 10 Feb 2023 | 818 | 179,365 (0%) | 0% | 29.8 | 24,376 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 29.10 per share. | 09 Feb 2023 | 25,000 | 2,229,031 (2%) | 0% | 29.1 | 727,500 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2023 | 25,000 | 1,220,617 | - | - | Stock Option (right to buy) | |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.68 per share. | 09 Feb 2023 | 25,000 | 2,254,031 (2%) | 0% | 0.7 | 17,000 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 30.59 per share. | 09 Feb 2023 | 3,433 | 2,229,031 (2%) | 0% | 30.6 | 105,015 | Common Stock |
| Steve E. Krognes | Director | Sale of securities on an exchange or to another person at price $ 30.88 per share. | 08 Feb 2023 | 1,377 | 145,121 (0%) | 0% | 30.9 | 42,522 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 30.89 per share. | 08 Feb 2023 | 1,521 | 499,902 (0%) | 0% | 30.9 | 46,984 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 30.88 per share. | 08 Feb 2023 | 1,521 | 180,183 (0%) | 0% | 30.9 | 46,968 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 29.53 per share. | 17 Jan 2023 | 9,886 | 497,287 (0%) | 0% | 29.5 | 291,934 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 10,000 | 98,937 | - | - | Stock Option (right to buy) | |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 29.87 per share. | 17 Jan 2023 | 114 | 497,173 (0%) | 0% | 29.9 | 3,405 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.28 per share. | 17 Jan 2023 | 10,000 | 507,173 (0%) | 0% | 5.3 | 52,800 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 28.48 per share. | 09 Jan 2023 | 1,459 | 177,454 (0%) | 0% | 28.5 | 41,552 | Common Stock |
| Steve E. Krognes | Director | Sale of securities on an exchange or to another person at price $ 28.44 per share. | 05 Jan 2023 | 2,970 | 146,498 (0%) | 0% | 28.4 | 84,467 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 28.44 per share. | 05 Jan 2023 | 4,800 | 2,223,664 (2%) | 0% | 28.4 | 136,512 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 28.44 per share. | 05 Jan 2023 | 2,636 | 497,173 (0%) | 0% | 28.4 | 74,968 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 28.44 per share. | 05 Jan 2023 | 2,636 | 180,364 (0%) | 0% | 28.4 | 74,968 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 28.67 per share. | 05 Jan 2023 | 1,451 | 178,913 (0%) | 0% | 28.7 | 41,600 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 82,240 | 231,934 (0%) | 0% | 0 | Common Stock | |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 28.73 per share. | 03 Jan 2023 | 5,029 | 2,213,464 (2%) | 0% | 28.7 | 144,483 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 246,720 | 246,720 | - | - | Stock Option (right to buy) | |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 28.70 per share. | 03 Jan 2023 | 2,912 | 492,309 (0%) | 0% | 28.7 | 83,574 | Common Stock |
| Carole Ho | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 41,120 | 138,967 (0%) | 0% | 0 | Common Stock | |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 28.69 per share. | 03 Jan 2023 | 2,913 | 175,500 (0%) | 0% | 28.7 | 83,574 | Common Stock |
| Carole Ho | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 123,360 | 123,360 | - | - | Stock Option (right to buy) | |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 30.48 per share. | 23 Nov 2022 | 20,000 | 1,870,356 (1%) | 0% | 30.5 | 609,600 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 30.20 per share. | 01 Nov 2022 | 8,748 | 1,901,608 (1%) | 0% | 30.2 | 264,190 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 30.33 per share. | 01 Nov 2022 | 11,252 | 1,890,356 (1%) | 0% | 30.3 | 341,273 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Oct 2022 | 20,000 | 220,078 | - | - | Stock Option (right to buy) | |
| Alexander O. Schuth | COFO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.68 per share. | 07 Oct 2022 | 20,000 | 487,471 (0%) | 0% | 0.7 | 13,600 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 31.08 per share. | 28 Sep 2022 | 4,423 | 1,910,356 (1%) | 0% | 31.1 | 137,467 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 30.74 per share. | 28 Sep 2022 | 15,577 | 1,914,779 (1%) | 0% | 30.7 | 478,837 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 32.43 per share. | 23 Aug 2022 | 100 | 1,930,356 (1%) | 0% | 32.4 | 3,243 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 31.61 per share. | 23 Aug 2022 | 19,900 | 1,930,456 (1%) | 0% | 31.6 | 629,039 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 31.98 per share. | 23 Aug 2022 | 2,424 | 170,663 (0%) | 0% | 32.0 | 77,520 | Common Stock |
| Steve E. Krognes | Director | Sale of securities on an exchange or to another person at price $ 33.22 per share. | 19 Aug 2022 | 2,253 | 149,468 (0%) | 0% | 33.2 | 74,845 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 33.22 per share. | 19 Aug 2022 | 2,404 | 2,202,993 (2%) | 0% | 33.2 | 79,861 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Sale of securities on an exchange or to another person at price $ 33.22 per share. | 19 Aug 2022 | 2,576 | 467,471 (0%) | 0% | 33.2 | 85,575 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 33.22 per share. | 19 Aug 2022 | 2,576 | 173,087 (0%) | 0% | 33.2 | 85,575 | Common Stock |
| Alexander O. Schuth | COFO and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Aug 2022 | 22,500 | 121,458 (0%) | 0% | 0 | Common Stock | |
| Carole Ho | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Aug 2022 | 22,500 | 110,597 (0%) | 0% | 0 | Common Stock | |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 35.60 per share. | 25 Jul 2022 | 19,800 | 1,950,556 (1%) | 0% | 35.6 | 704,880 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 36.15 per share. | 25 Jul 2022 | 200 | 1,950,356 (1%) | 0% | 36.2 | 7,230 | Common Stock |
| Steve E. Krognes | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.68 per share. | 19 Jul 2022 | 62,500 | 151,721 (0%) | 0% | 0.7 | 42,500 | Common Stock |
| Steve E. Krognes | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Jul 2022 | 62,500 | 0 | - | - | Stock Option (right to buy) | |
| Marc Tessier-Lavigne | Director | Sale or transfer of securities back to the company at price $ 31.10 per share. | 23 Jun 2022 | 13,250 | 2,017,106 (1%) | 0% | 31.1 | 412,076 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale or transfer of securities back to the company at price $ 30.53 per share. | 23 Jun 2022 | 39,984 | 1,977,122 (1%) | 0% | 30.5 | 1,220,708 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale or transfer of securities back to the company at price $ 31.08 per share. | 23 Jun 2022 | 6,766 | 1,970,356 (1%) | 0% | 31.1 | 210,261 | Common Stock |
| Jay T. Flatley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 5,986 | 336,313 (0%) | 0% | 0 | Common Stock | |
| Jay T. Flatley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 17,959 | 17,959 | - | - | Stock Option (right to buy) | |
| Marc Tessier-Lavigne | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 17,959 | 17,959 | - | - | Stock Option (right to buy) | |
| Marc Tessier-Lavigne | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 5,986 | 2,030,356 (1%) | 0% | 0 | Common Stock | |
| Vicki L. Sato | Director | 02 Jun 2022 | 17,959 | 17,959 | - | - | Stock Option (right to buy) | ||
| Vicki L. Sato | Director | 02 Jun 2022 | 5,986 | 142,149 (0%) | 0% | 0 | Common Stock | ||
| Peter S. Klein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 5,986 | 11,313 (0%) | 0% | 0 | Common Stock | |
| Peter S. Klein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 17,959 | 17,959 | - | - | Stock Option (right to buy) | |
| Douglas G. Cole | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 5,986 | 22,348 (0%) | 0% | 0 | Common Stock | |
| Douglas G. Cole | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 17,959 | 17,959 | - | - | Stock Option (right to buy) | |
| David P. Schenkein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 17,959 | 17,959 | - | - | Stock Option (right to buy) | |
| David P. Schenkein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 5,986 | 11,313 (0%) | 0% | 0 | Common Stock | |
| Jennifer Cook | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 5,986 | 11,313 (0%) | 0% | 0 | Common Stock | |
| Jennifer Cook | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 17,959 | 17,959 | - | - | Stock Option (right to buy) | |
| Nancy Thornberry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 17,959 | 17,959 | - | - | Stock Option (right to buy) | |
| Nancy Thornberry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 5,986 | 8,497 (0%) | 0% | 0 | Common Stock | |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 33.40 per share. | 23 Mar 2022 | 8,402 | 2,035,968 (1%) | 0% | 33.4 | 280,627 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 34.14 per share. | 23 Mar 2022 | 11,598 | 2,024,370 (1%) | 0% | 34.1 | 395,956 | Common Stock |
| Steve E. Krognes | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 34.69 per share. | 11 Feb 2022 | 2,560 | 120,221 (0%) | 0% | 34.7 | 88,806 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 34.72 per share. | 11 Feb 2022 | 9,491 | 2,129,648 (2%) | 0% | 34.7 | 329,528 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 34.68 per share. | 11 Feb 2022 | 2,803 | 465,047 (0%) | 0% | 34.7 | 97,208 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 34.71 per share. | 11 Feb 2022 | 2,918 | 170,663 (0%) | 0% | 34.7 | 101,284 | Common Stock |
| Steve E. Krognes | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 37.09 per share. | 09 Feb 2022 | 1,296 | 122,781 (0%) | 0% | 37.1 | 48,073 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.60 per share. | 09 Feb 2022 | 6,118 | 260,640 (0%) | 0% | 9.6 | 58,733 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2022 | 6,118 | 0 | - | - | Stock Option (right to buy) | |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2022 | 64,631 | 0 | - | - | Stock Option (right to buy) | |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.28 per share. | 09 Feb 2022 | 64,631 | 254,522 (0%) | 0% | 5.3 | 341,252 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 37.55 per share. | 09 Feb 2022 | 2,719 | 2,119,442 (2%) | 0% | 37.6 | 102,104 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 37.10 per share. | 09 Feb 2022 | 1,423 | 460,564 (0%) | 0% | 37.1 | 52,800 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 37.10 per share. | 09 Feb 2022 | 1,423 | 166,112 (0%) | 0% | 37.1 | 52,791 | Common Stock |
| Erik Harris | Director | 03 Feb 2022 | 20,607 | 20,607 | - | - | Stock Option (right to buy) | ||
| Erik Harris | Director | 03 Feb 2022 | 6,869 | 6,869 (0%) | 0% | 0 | Common Stock | ||
| Nancy Thornberry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jan 2022 | 627 | 2,511 (0%) | 0% | 0 | Common Stock | |
| Steve E. Krognes | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 44.75 per share. | 05 Jan 2022 | 2,225 | 124,077 (0%) | 0% | 44.8 | 99,569 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 44.78 per share. | 05 Jan 2022 | 5,007 | 2,113,361 (2%) | 0% | 44.8 | 224,213 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 44.77 per share. | 05 Jan 2022 | 2,846 | 457,737 (0%) | 0% | 44.8 | 127,415 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 44.78 per share. | 05 Jan 2022 | 2,845 | 163,285 (0%) | 0% | 44.8 | 127,399 | Common Stock |
| Steve E. Krognes | CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2022 | 93,000 | 93,000 | - | - | Stock Option (right to buy) | |
| Steve E. Krognes | CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2022 | 31,000 | 126,302 (0%) | 0% | 0 | Common Stock | |
| Ryan J. Watts | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2022 | 62,000 | 213,691 (0%) | 0% | 0 | Common Stock | |
| Ryan J. Watts | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2022 | 186,500 | 186,500 | - | - | Stock Option (right to buy) | |
| Alexander O. Schuth | COO and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2022 | 93,000 | 93,000 | - | - | Stock Option (right to buy) | |
| Alexander O. Schuth | COO and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2022 | 31,000 | 117,454 (0%) | 0% | 0 | Common Stock | |
| Carole Ho | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2022 | 31,000 | 107,316 (0%) | 0% | 0 | Common Stock | |
| Carole Ho | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2022 | 93,000 | 93,000 | - | - | Stock Option (right to buy) | |
| Marc Tessier-Lavigne | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 28 Dec 2021 | 300,000 | 2,244,370 (2%) | 0% | 0 | Common Stock | |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 45.72 per share. | 28 Dec 2021 | 800 | 78,848 (0%) | 0% | 45.7 | 36,576 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 45.31 per share. | 28 Dec 2021 | 6,002 | 79,648 (0%) | 0% | 45.3 | 271,951 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 43.88 per share. | 28 Dec 2021 | 10,704 | 85,650 (0%) | 0% | 43.9 | 469,692 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 44.37 per share. | 28 Dec 2021 | 3,646 | 96,354 (0%) | 0% | 44.4 | 161,773 | Common Stock |
| Marc Tessier-Lavigne | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 28 Dec 2021 | 100,000 | 100,000 (0%) | 0% | 0 | Common Stock | |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 45.71 per share. | 28 Dec 2021 | 900 | 79,173 (0%) | 0% | 45.7 | 41,139 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 45.31 per share. | 28 Dec 2021 | 5,625 | 80,073 (0%) | 0% | 45.3 | 254,869 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 43.87 per share. | 28 Dec 2021 | 10,700 | 85,698 (0%) | 0% | 43.9 | 469,409 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 44.38 per share. | 28 Dec 2021 | 3,602 | 96,398 (0%) | 0% | 44.4 | 159,857 | Common Stock |
| Marc Tessier-Lavigne | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 28 Dec 2021 | 100,000 | 100,000 (0%) | 0% | 0 | Common Stock | |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 45.59 per share. | 28 Dec 2021 | 3,377 | 78,848 (0%) | 0% | 45.6 | 153,957 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 45.13 per share. | 28 Dec 2021 | 3,343 | 82,225 (0%) | 0% | 45.1 | 150,870 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 43.88 per share. | 28 Dec 2021 | 10,700 | 85,568 (0%) | 0% | 43.9 | 469,516 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 44.37 per share. | 28 Dec 2021 | 3,732 | 96,268 (0%) | 0% | 44.4 | 165,589 | Common Stock |
| Marc Tessier-Lavigne | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 28 Dec 2021 | 100,000 | 100,000 (0%) | 0% | 0 | Common Stock | |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 42.45 per share. | 06 Dec 2021 | 7,200 | 453,083 (0%) | 0% | 42.5 | 305,640 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 41.82 per share. | 06 Dec 2021 | 2,800 | 460,283 (0%) | 0% | 41.8 | 117,096 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 42.52 per share. | 06 Dec 2021 | 1,476 | 76,316 (0%) | 0% | 42.5 | 62,760 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 45.30 per share. | 01 Dec 2021 | 9,012 | 2,104,173 (1%) | 0% | 45.3 | 408,244 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 46.35 per share. | 01 Dec 2021 | 805 | 2,103,368 (1%) | 0% | 46.4 | 37,312 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 44.39 per share. | 01 Dec 2021 | 8,516 | 2,113,185 (2%) | 0% | 44.4 | 378,025 | Common Stock |
| Vicki L. Sato | Director | 10 Nov 2021 | 660 | 126,167 (0%) | 0% | 53.3 | 35,178 | Common Stock | |
| Vicki L. Sato | Director | 10 Nov 2021 | 1,006 | 126,827 (0%) | 0% | 52.5 | 52,805 | Common Stock | |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 53.23 per share. | 04 Nov 2021 | 3,283 | 463,083 (0%) | 0% | 53.2 | 174,754 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 52.65 per share. | 04 Nov 2021 | 6,717 | 466,366 (0%) | 0% | 52.6 | 353,650 | Common Stock |
| Vicki L. Sato | Director | 01 Nov 2021 | 1,666 | 127,833 (0%) | 0% | 50.0 | 83,383 | Common Stock | |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 49.87 per share. | 01 Nov 2021 | 16,674 | 2,121,701 (2%) | 0% | 49.9 | 831,532 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 48.61 per share. | 01 Nov 2021 | 1,659 | 2,138,375 (2%) | 0% | 48.6 | 80,644 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 51.04 per share. | 04 Oct 2021 | 4,006 | 473,083 (0%) | 0% | 51.0 | 204,466 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 50.24 per share. | 04 Oct 2021 | 5,994 | 477,089 (0%) | 0% | 50.2 | 301,139 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 50.44 per share. | 01 Oct 2021 | 10,782 | 2,144,281 (2%) | 0% | 50.4 | 543,844 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 50.99 per share. | 01 Oct 2021 | 4,247 | 2,140,034 (2%) | 0% | 51.0 | 216,555 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 49.38 per share. | 01 Oct 2021 | 3,304 | 2,155,063 (2%) | 0% | 49.4 | 163,152 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Sep 2021 | 9,045 | 240,078 | - | - | Stock Option (right to buy) | |
| Alexander O. Schuth | COO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.68 per share. | 20 Sep 2021 | 9,045 | 95,499 (0%) | 0% | 0.7 | 6,151 | Common Stock |
| Vicki L. Sato | Director | 15 Sep 2021 | 676 | 130,259 (0%) | 0% | 53.0 | 35,848 | Common Stock | |
| Vicki L. Sato | Director | 15 Sep 2021 | 140 | 129,499 (0%) | 0% | 54.8 | 7,666 | Common Stock | |
| Vicki L. Sato | Director | 15 Sep 2021 | 620 | 129,639 (0%) | 0% | 53.9 | 33,430 | Common Stock | |
| Vicki L. Sato | Director | 15 Sep 2021 | 230 | 130,935 (0%) | 0% | 52.3 | 12,024 | Common Stock | |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 55.67 per share. | 07 Sep 2021 | 5,350 | 476,479 (0%) | 0% | 55.7 | 297,835 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 56.05 per share. | 07 Sep 2021 | 2,441 | 474,038 (0%) | 0% | 56.0 | 136,818 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 54.70 per share. | 07 Sep 2021 | 2,209 | 481,829 (0%) | 0% | 54.7 | 120,832 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 54.92 per share. | 01 Sep 2021 | 10,892 | 2,158,367 (2%) | 0% | 54.9 | 598,189 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 54.27 per share. | 01 Sep 2021 | 7,441 | 2,169,259 (2%) | 0% | 54.3 | 403,823 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 48.91 per share. | 23 Aug 2021 | 6,143 | 158,630 (0%) | 0% | 48.9 | 300,454 | Common Stock |
| Steve E. Krognes | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 50.07 per share. | 19 Aug 2021 | 200 | 95,302 (0%) | 0% | 50.1 | 10,014 | Common Stock |
| Steve E. Krognes | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 49.52 per share. | 19 Aug 2021 | 2,085 | 95,502 (0%) | 0% | 49.5 | 103,249 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 49.97 per share. | 19 Aug 2021 | 750 | 2,176,700 (2%) | 0% | 50.0 | 37,478 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 49.38 per share. | 19 Aug 2021 | 1,626 | 2,177,450 (2%) | 0% | 49.4 | 80,292 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 50.10 per share. | 19 Aug 2021 | 196 | 484,038 (0%) | 0% | 50.1 | 9,820 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 49.56 per share. | 19 Aug 2021 | 2,348 | 484,234 (0%) | 0% | 49.6 | 116,367 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 49.31 per share. | 19 Aug 2021 | 1,402 | 165,917 (0%) | 0% | 49.3 | 69,133 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 49.91 per share. | 19 Aug 2021 | 1,144 | 164,773 (0%) | 0% | 49.9 | 57,097 | Common Stock |
| Vicki L. Sato | Director | 18 Aug 2021 | 806 | 132,025 (0%) | 0% | 51.3 | 41,316 | Common Stock | |
| Vicki L. Sato | Director | 18 Aug 2021 | 860 | 131,165 (0%) | 0% | 52.1 | 44,823 | Common Stock | |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 52.34 per share. | 04 Aug 2021 | 8,236 | 481,782 (0%) | 0% | 52.3 | 431,064 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 52.99 per share. | 04 Aug 2021 | 200 | 481,582 (0%) | 0% | 53.0 | 10,598 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 51.52 per share. | 04 Aug 2021 | 1,564 | 490,018 (0%) | 0% | 51.5 | 80,571 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 51.94 per share. | 02 Aug 2021 | 9,790 | 2,174,076 (2%) | 0% | 51.9 | 508,493 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 50.80 per share. | 02 Aug 2021 | 8,543 | 2,183,866 (2%) | 0% | 50.8 | 433,984 | Common Stock |
| Vicki L. Sato | Director | 21 Jul 2021 | 400 | 132,831 (0%) | 0% | 65.8 | 26,312 | Common Stock | |
| Vicki L. Sato | Director | 21 Jul 2021 | 866 | 133,231 (0%) | 0% | 65.2 | 56,498 | Common Stock | |
| Vicki L. Sato | Director | 21 Jul 2021 | 400 | 134,097 (0%) | 0% | 64.3 | 25,700 | Common Stock | |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 76.20 per share. | 06 Jul 2021 | 10,000 | 491,582 (0%) | 0% | 76.2 | 762,040 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 77.35 per share. | 01 Jul 2021 | 12,844 | 2,194,868 (2%) | 0% | 77.3 | 993,471 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 77.84 per share. | 01 Jul 2021 | 2,459 | 2,192,409 (2%) | 0% | 77.8 | 191,401 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 76.38 per share. | 01 Jul 2021 | 3,030 | 2,207,712 (2%) | 0% | 76.4 | 231,428 | Common Stock |
| Vicki L. Sato | Director | 23 Jun 2021 | 986 | 134,497 (0%) | 0% | 71.1 | 70,110 | Common Stock | |
| Vicki L. Sato | Director | 23 Jun 2021 | 680 | 135,483 (0%) | 0% | 70.2 | 47,735 | Common Stock | |
| Marc Tessier-Lavigne | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.92 per share. | 07 Jun 2021 | 27,830 | 2,611,503 (2%) | 0% | 18.9 | 526,544 | Common Stock |
| Marc Tessier-Lavigne | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jun 2021 | 27,245 | 0 | - | - | Stock Option (right to buy) | |
| Marc Tessier-Lavigne | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jun 2021 | 27,830 | 0 | - | - | Stock Option (right to buy) | |
| Marc Tessier-Lavigne | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jun 2021 | 39,303 | 7,862 | - | - | Stock Option (right to buy) | |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 71.06 per share. | 07 Jun 2021 | 700 | 2,544,370 (2%) | 0% | 71.1 | 49,744 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 70.35 per share. | 07 Jun 2021 | 93,678 | 2,545,070 (2%) | 0% | 70.3 | 6,589,779 | Common Stock |
| Marc Tessier-Lavigne | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.50 per share. | 07 Jun 2021 | 27,245 | 2,638,748 (2%) | 0% | 19.5 | 531,278 | Common Stock |
| Marc Tessier-Lavigne | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.00 per share. | 07 Jun 2021 | 39,303 | 2,583,673 (2%) | 0% | 18 | 707,454 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 64.82 per share. | 04 Jun 2021 | 4,340 | 501,582 (0%) | 0% | 64.8 | 281,301 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 64.35 per share. | 04 Jun 2021 | 5,660 | 505,922 (0%) | 0% | 64.3 | 364,198 | Common Stock |
| Jay T. Flatley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 2,074 | 330,327 (0%) | 0% | 0 | Common Stock | |
| Jay T. Flatley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 6,222 | 6,222 | - | - | Stock Option (right to buy) | |
| Marc Tessier-Lavigne | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 2,074 | 2,544,370 (2%) | 0% | 0 | Common Stock | |
| Marc Tessier-Lavigne | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 6,222 | 6,222 | - | - | Stock Option (right to buy) | |
| Robert Taylor Nelsen | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 6,222 | 6,222 | - | - | Stock Option (right to buy) | |
| Robert Taylor Nelsen | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 2,074 | 12,432 (0%) | 0% | 0 | Common Stock | |
| Vicki L. Sato | Director | 02 Jun 2021 | 6,222 | 6,222 | - | - | Stock Option (right to buy) | ||
| Vicki L. Sato | Director | 02 Jun 2021 | 2,074 | 136,163 (0%) | 0% | 0 | Common Stock | ||
| Peter S. Klein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 6,222 | 6,222 | - | - | Stock Option (right to buy) | |
| Peter S. Klein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 2,074 | 5,327 (0%) | 0% | 0 | Common Stock | |
| Douglas G. Cole | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 2,074 | 5,327 (0%) | 0% | 0 | Common Stock | |
| Douglas G. Cole | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 6,222 | 6,222 | - | - | Stock Option (right to buy) | |
| David P. Schenkein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 2,074 | 5,327 (0%) | 0% | 0 | Common Stock | |
| David P. Schenkein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 6,222 | 6,222 | - | - | Stock Option (right to buy) | |
| Jennifer Cook | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 2,074 | 5,327 (0%) | 0% | 0 | Common Stock | |
| Jennifer Cook | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 6,222 | 6,222 | - | - | Stock Option (right to buy) | |
| Jay T. Flatley | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2021 | 3,253 | 328,253 (0%) | 0% | 0 | Common Stock | |
| Jay T. Flatley | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2021 | 3,253 | 0 | - | - | Restricted Stock Units | |
| Peter S. Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2021 | 3,253 | 3,253 (0%) | 0% | 0 | Common Stock | |
| Peter S. Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2021 | 3,253 | 0 | - | - | Restricted Stock Units | |
| Douglas G. Cole | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2021 | 3,253 | 3,253 (0%) | 0% | 0 | Common Stock | |
| Douglas G. Cole | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2021 | 3,253 | 0 | - | - | Restricted Stock Units | |
| David P. Schenkein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2021 | 3,253 | 0 | - | - | Restricted Stock Units | |
| David P. Schenkein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2021 | 3,253 | 3,253 (0%) | 0% | 0 | Common Stock | |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 62.75 per share. | 01 Jun 2021 | 2,102 | 2,211,096 (2%) | 0% | 62.8 | 131,911 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 63.50 per share. | 01 Jun 2021 | 354 | 2,210,742 (2%) | 0% | 63.5 | 22,479 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 62.09 per share. | 01 Jun 2021 | 2,750 | 2,213,198 (2%) | 0% | 62.1 | 170,748 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 60.98 per share. | 01 Jun 2021 | 13,127 | 2,215,948 (2%) | 0% | 61.0 | 800,511 | Common Stock |
| Jennifer Cook | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2021 | 3,253 | 0 | - | - | Restricted Stock Units | |
| Jennifer Cook | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2021 | 3,253 | 3,253 (0%) | 0% | 0 | Common Stock | |
| Vicki L. Sato | Director | 26 May 2021 | 40 | 134,089 (0%) | 0% | 66.7 | 2,669 | Common Stock | |
| Vicki L. Sato | Director | 26 May 2021 | 732 | 134,129 (0%) | 0% | 65.9 | 48,221 | Common Stock | |
| Vicki L. Sato | Director | 26 May 2021 | 894 | 134,861 (0%) | 0% | 64.9 | 58,022 | Common Stock | |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 60.13 per share. | 21 May 2021 | 37,957 | 2,551,102 (2%) | 0% | 60.1 | 2,282,468 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 60.02 per share. | 21 May 2021 | 8,806 | 2,542,296 (2%) | 0% | 60.0 | 528,580 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 55.92 per share. | 04 May 2021 | 3,557 | 512,027 (0%) | 0% | 55.9 | 198,890 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 57.39 per share. | 04 May 2021 | 445 | 511,582 (0%) | 0% | 57.4 | 25,539 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 55.09 per share. | 04 May 2021 | 5,998 | 515,584 (0%) | 0% | 55.1 | 330,436 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 61.20 per share. | 03 May 2021 | 98 | 2,589,059 (2%) | 0% | 61.2 | 5,998 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 60.08 per share. | 03 May 2021 | 3,139 | 2,589,157 (2%) | 0% | 60.1 | 188,591 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 58.45 per share. | 03 May 2021 | 13,997 | 2,233,411 (2%) | 0% | 58.4 | 818,083 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 59.92 per share. | 03 May 2021 | 851 | 2,229,075 (2%) | 0% | 59.9 | 50,989 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 59.12 per share. | 03 May 2021 | 3,485 | 2,229,926 (2%) | 0% | 59.1 | 206,030 | Common Stock |
| Vicki L. Sato | Director | 28 Apr 2021 | 688 | 135,755 (0%) | 0% | 63.0 | 43,367 | Common Stock | |
| Vicki L. Sato | Director | 28 Apr 2021 | 381 | 137,040 (0%) | 0% | 60.7 | 23,129 | Common Stock | |
| Vicki L. Sato | Director | 28 Apr 2021 | 597 | 136,443 (0%) | 0% | 62.0 | 37,042 | Common Stock | |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 57.44 per share. | 05 Apr 2021 | 700 | 521,582 (0%) | 0% | 57.4 | 40,206 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 56.47 per share. | 05 Apr 2021 | 4,156 | 522,282 (0%) | 0% | 56.5 | 234,669 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 55.60 per share. | 05 Apr 2021 | 5,144 | 526,438 (0%) | 0% | 55.6 | 286,027 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 56.91 per share. | 01 Apr 2021 | 29,593 | 2,598,480 (2%) | 0% | 56.9 | 1,684,019 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 57.59 per share. | 01 Apr 2021 | 6,184 | 2,592,296 (2%) | 0% | 57.6 | 356,167 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 55.61 per share. | 01 Apr 2021 | 14,223 | 2,628,073 (2%) | 0% | 55.6 | 790,884 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 55.52 per share. | 01 Apr 2021 | 5,232 | 2,260,510 (2%) | 0% | 55.5 | 290,486 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 57.31 per share. | 01 Apr 2021 | 4,586 | 2,247,408 (2%) | 0% | 57.3 | 262,842 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 56.88 per share. | 01 Apr 2021 | 8,516 | 2,251,994 (2%) | 0% | 56.9 | 484,356 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 01 Apr 2021 | 40,000 | 2,265,742 (2%) | 0% | 0 | Common Stock | |
| Vicki L. Sato | Director | 31 Mar 2021 | 877 | 138,192 (0%) | 0% | 55.9 | 49,034 | Common Stock | |
| Vicki L. Sato | Director | 31 Mar 2021 | 136 | 137,421 (0%) | 0% | 57.6 | 7,834 | Common Stock | |
| Vicki L. Sato | Director | 31 Mar 2021 | 635 | 137,557 (0%) | 0% | 56.9 | 36,145 | Common Stock | |
| Vicki L. Sato | Director | 31 Mar 2021 | 18 | 139,069 (0%) | 0% | 54.4 | 979 | Common Stock | |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 54.62 per share. | 29 Mar 2021 | 2,822 | 162,319 (0%) | 0% | 54.6 | 154,126 | Common Stock |
| Robert Taylor Nelsen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Mar 2021 | 3,253 | 10,358 (0%) | 0% | 0 | Common Stock | |
| Robert Taylor Nelsen | Director | Other type of transaction at price $ 0.00 per share. | 22 Mar 2021 | 500,000 | 10,168,749 (9%) | 0% | 0 | Common Stock | |
| Robert Taylor Nelsen | Director | Other type of transaction at price $ 0.00 per share. | 22 Mar 2021 | 500,000 | 9,668,749 (9%) | 0% | 0 | Common Stock | |
| Robert Taylor Nelsen | Director | Other type of transaction at price $ 0.00 per share. | 22 Mar 2021 | 2,538 | 4,568 (0%) | 0% | 0 | Common Stock | |
| Robert Taylor Nelsen | Director | Other type of transaction at price $ 0.00 per share. | 22 Mar 2021 | 2,537 | 7,105 (0%) | 0% | 0 | Common Stock | |
| Robert Taylor Nelsen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Mar 2021 | 3,253 | 0 | - | - | Restricted Stock Units | |
| Steve E. Krognes | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 62.71 per share. | 15 Mar 2021 | 3,258 | 851,158 (0%) | 0% | 62.7 | 204,319 | Common Stock |
| Steve E. Krognes | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 63.67 per share. | 15 Mar 2021 | 1,158 | 850,000 (0%) | 0% | 63.7 | 73,730 | Common Stock |
| Steve E. Krognes | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 61.16 per share. | 15 Mar 2021 | 13,258 | 886,742 (0%) | 0% | 61.2 | 810,912 | Common Stock |
| Steve E. Krognes | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 62.04 per share. | 15 Mar 2021 | 32,326 | 854,416 (0%) | 0% | 62.0 | 2,005,602 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 61.58 per share. | 04 Mar 2021 | 1,878 | 531,582 (0%) | 0% | 61.6 | 115,647 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 60.89 per share. | 04 Mar 2021 | 8,122 | 533,460 (0%) | 0% | 60.9 | 494,524 | Common Stock |
| Vicki L. Sato | Director | 03 Mar 2021 | 235 | 140,518 (0%) | 0% | 60.4 | 14,185 | Common Stock | |
| Vicki L. Sato | Director | 03 Mar 2021 | 1,050 | 139,468 (0%) | 0% | 61.5 | 64,600 | Common Stock | |
| Vicki L. Sato | Director | 03 Mar 2021 | 266 | 139,202 (0%) | 0% | 62.3 | 16,569 | Common Stock | |
| Vicki L. Sato | Director | 03 Mar 2021 | 115 | 139,087 (0%) | 0% | 63.4 | 7,287 | Common Stock | |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 68.50 per share. | 01 Mar 2021 | 6,011 | 2,646,809 (2%) | 0% | 68.5 | 411,778 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 71.35 per share. | 01 Mar 2021 | 1,031 | 2,642,296 (2%) | 0% | 71.4 | 73,563 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 69.59 per share. | 01 Mar 2021 | 3,482 | 2,643,327 (2%) | 0% | 69.6 | 242,309 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 67.57 per share. | 01 Mar 2021 | 14,945 | 2,652,820 (2%) | 0% | 67.6 | 1,009,834 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 66.55 per share. | 01 Mar 2021 | 18,316 | 2,667,765 (2%) | 0% | 66.6 | 1,219,003 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 65.63 per share. | 01 Mar 2021 | 37,445 | 2,686,081 (2%) | 0% | 65.6 | 2,457,665 | Common Stock |
| Marc Tessier-Lavigne | Director | Sale of securities on an exchange or to another person at price $ 64.36 per share. | 01 Mar 2021 | 18,770 | 2,723,526 (2%) | 0% | 64.4 | 1,208,056 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 64.42 per share. | 01 Mar 2021 | 3,370 | 2,320,706 (2%) | 0% | 64.4 | 217,106 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 70.93 per share. | 01 Mar 2021 | 68 | 2,305,742 (2%) | 0% | 70.9 | 4,823 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 69.65 per share. | 01 Mar 2021 | 594 | 2,305,810 (2%) | 0% | 69.6 | 41,371 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 68.46 per share. | 01 Mar 2021 | 1,625 | 2,306,404 (2%) | 0% | 68.5 | 111,246 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 67.69 per share. | 01 Mar 2021 | 3,339 | 2,308,029 (2%) | 0% | 67.7 | 226,017 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 66.55 per share. | 01 Mar 2021 | 3,453 | 2,311,368 (2%) | 0% | 66.5 | 229,780 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 65.63 per share. | 01 Mar 2021 | 5,885 | 2,314,821 (2%) | 0% | 65.6 | 386,209 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 65.73 per share. | 01 Mar 2021 | 2,871 | 168,035 (0%) | 0% | 65.7 | 188,725 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 64.54 per share. | 01 Mar 2021 | 1,327 | 170,906 (0%) | 0% | 64.5 | 85,646 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 71.26 per share. | 01 Mar 2021 | 68 | 165,141 (0%) | 0% | 71.3 | 4,846 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 70.06 per share. | 01 Mar 2021 | 125 | 165,209 (0%) | 0% | 70.1 | 8,758 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 68.87 per share. | 01 Mar 2021 | 208 | 165,334 (0%) | 0% | 68.9 | 14,324 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 68.01 per share. | 01 Mar 2021 | 1,320 | 165,542 (0%) | 0% | 68.0 | 89,772 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 67.07 per share. | 01 Mar 2021 | 1,173 | 166,862 (0%) | 0% | 67.1 | 78,670 | Common Stock |
| Steve E. Krognes | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 65.04 per share. | 16 Feb 2021 | 10,199 | 917,117 (0%) | 0% | 65.0 | 663,323 | Common Stock |
| Steve E. Krognes | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 66.80 per share. | 16 Feb 2021 | 501 | 900,000 (0%) | 0% | 66.8 | 33,468 | Common Stock |
| Steve E. Krognes | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 66.20 per share. | 16 Feb 2021 | 16,616 | 900,501 (0%) | 0% | 66.2 | 1,099,996 | Common Stock |
| Steve E. Krognes | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 64.27 per share. | 16 Feb 2021 | 22,684 | 927,316 (0%) | 0% | 64.3 | 1,457,923 | Common Stock |
| Douglas K. Bratton | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 65.00 per share. | 12 Feb 2021 | 2,216,798 | 9,984,836 (9%) | 2% | 65 | 144,091,870 | Common Stock |
| Steve E. Krognes | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 71.43 per share. | 11 Feb 2021 | 400 | 97,587 (0%) | 0% | 71.4 | 28,571 | Common Stock |
| Steve E. Krognes | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 70.17 per share. | 11 Feb 2021 | 2,635 | 97,987 (0%) | 0% | 70.2 | 184,908 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 70.17 per share. | 11 Feb 2021 | 8,513 | 2,325,036 (2%) | 0% | 70.2 | 597,374 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 71.47 per share. | 11 Feb 2021 | 960 | 2,324,076 (2%) | 0% | 71.5 | 68,610 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 70.17 per share. | 11 Feb 2021 | 2,614 | 542,015 (0%) | 0% | 70.2 | 183,422 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 71.41 per share. | 11 Feb 2021 | 433 | 541,582 (0%) | 0% | 71.4 | 30,920 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 71.48 per share. | 11 Feb 2021 | 400 | 172,233 (0%) | 0% | 71.5 | 28,594 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 70.17 per share. | 11 Feb 2021 | 2,756 | 172,633 (0%) | 0% | 70.2 | 193,377 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 74.05 per share. | 08 Feb 2021 | 1,634 | 2,314,664 (2%) | 0% | 74.1 | 120,999 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2021 | 8,800 | 17,600 | - | - | Restricted Stock Units | |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2021 | 5,516 | 0 | - | - | Restricted Stock Units | |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 75.07 per share. | 08 Feb 2021 | 811 | 2,313,853 (2%) | 0% | 75.1 | 60,883 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 73.24 per share. | 08 Feb 2021 | 2,667 | 2,316,298 (2%) | 0% | 73.2 | 195,328 | Common Stock |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2021 | 8,800 | 2,318,965 (2%) | 0% | 0 | Common Stock | |
| Ryan J. Watts | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2021 | 5,516 | 2,310,165 (2%) | 0% | 0 | Common Stock | |
| Steve E. Krognes | CFO and Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2021 | 4,250 | 8,500 | - | - | Restricted Stock Units | |
| Steve E. Krognes | CFO and Treasurer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2021 | 4,250 | 14,427 (0%) | 0% | 0 | Common Stock | |
| Steve E. Krognes | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 75.39 per share. | 07 Feb 2021 | 426 | 12,979 (0%) | 0% | 75.4 | 32,116 | Common Stock |
| Steve E. Krognes | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 74.38 per share. | 07 Feb 2021 | 1,022 | 13,405 (0%) | 0% | 74.4 | 76,018 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2021 | 4,250 | 538,812 (0%) | 0% | 0 | Common Stock | |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 74.66 per share. | 07 Feb 2021 | 1,262 | 537,550 (0%) | 0% | 74.7 | 94,218 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 75.68 per share. | 07 Feb 2021 | 206 | 537,344 (0%) | 0% | 75.7 | 15,591 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2021 | 4,250 | 8,500 | - | - | Restricted Stock Units | |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 76.00 per share. | 07 Feb 2021 | 100 | 167,921 (0%) | 0% | 76 | 7,600 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 75.10 per share. | 07 Feb 2021 | 364 | 168,021 (0%) | 0% | 75.1 | 27,337 | Common Stock |
| Carole Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 74.40 per share. | 07 Feb 2021 | 1,006 | 168,385 (0%) | 0% | 74.4 | 74,847 | Common Stock |
| Carole Ho | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2021 | 4,250 | 169,391 (0%) | 0% | 0 | Common Stock | |
| Carole Ho | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2021 | 4,250 | 8,500 | - | - | Restricted Stock Units | |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 67.90 per share. | 04 Feb 2021 | 6,509 | 536,474 (0%) | 0% | 67.9 | 441,942 | Common Stock |
| Alexander O. Schuth | COO and Secretary | Sale of securities on an exchange or to another person at price $ 68.61 per share. | 04 Feb 2021 | 1,912 | 534,562 (0%) | 0% | 68.6 | 131,180 | Common Stock |