XNAS 04 May, 2026 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 71.79 per share. | 28 Apr 2026 | 1,626 | 44,909 (0%) | 0% | 71.8 | 116,727 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2026 | 1,875 | 68,473 (0%) | 0% | 0 | Common Stock | |
| Brian Birchler | EVP, Corp and Development Ops | Sale of securities on an exchange or to another person at price $ 75.04 per share. | 15 Apr 2026 | 973 | 67,500 (0%) | 0% | 75.0 | 73,016 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2026 | 1,875 | 48,926 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2026 | 10,837 | 48,312 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 74.56 per share. | 15 Apr 2026 | 5,619 | 46,535 (0%) | 0% | 74.6 | 418,953 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2026 | 10,837 | 52,154 (0%) | 0% | 0 | Common Stock | |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2026 | 12,226 | 28,615 (0%) | 0% | 0 | Common Stock | |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2026 | 12,226 | 74,402 | - | - | Restricted Stock Unit | |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Sale of securities on an exchange or to another person at price $ 75.17 per share. | 15 Apr 2026 | 4,902 | 23,713 (0%) | 0% | 75.2 | 368,488 | Common Stock |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 76.19 per share. | 15 Apr 2026 | 4,466 | 51,878 (0%) | 0% | 76.2 | 340,265 | Common Stock |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 76.97 per share. | 15 Apr 2026 | 534 | 51,344 (0%) | 0% | 77.0 | 41,102 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Sale of securities on an exchange or to another person at price $ 74.05 per share. | 02 Apr 2026 | 6,193 | 16,348 (0%) | 0% | 74.1 | 458,613 | Common Stock |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 41.08 per share. | 01 Apr 2026 | 10,321 | 33,335 (0%) | 0% | 41.1 | 423,987 | Common Stock |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 75.50 per share. | 01 Apr 2026 | 20,105 | 13,230 (0%) | 0% | 75.5 | 1,517,988 | Common Stock |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.06 per share. | 01 Apr 2026 | 12,000 | 23,014 (0%) | 0% | 38.1 | 456,720 | Common Stock |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2026 | 10,321 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2026 | 12,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 75.95 per share. | 01 Apr 2026 | 2,216 | 11,014 (0%) | 0% | 76.0 | 168,314 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 70.97 per share. | 19 Mar 2026 | 5,812 | 63,890 (0%) | 0% | 71.0 | 412,486 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Sale of securities on an exchange or to another person at price $ 72.38 per share. | 16 Mar 2026 | 205,608 | 102,272 (0%) | 0% | 72.4 | 14,882,113 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 16 Mar 2026 | 61,041 | 254,221 (0%) | 0% | 56.8 | 3,465,908 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 16 Mar 2026 | 33,118 | 287,339 (0%) | 0% | 32.6 | 1,079,647 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.58 per share. | 16 Mar 2026 | 20,541 | 307,880 (0%) | 0% | 37.6 | 771,931 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Mar 2026 | 60,299 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Mar 2026 | 61,041 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Mar 2026 | 20,541 | 5,405 | - | - | Non-Qualified Stock Option (right to buy) | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Mar 2026 | 33,118 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Sale of securities on an exchange or to another person at price $ 73.21 per share. | 16 Mar 2026 | 10,172 | 82,660 (0%) | 0% | 73.2 | 744,662 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Sale of securities on an exchange or to another person at price $ 72.77 per share. | 16 Mar 2026 | 9,440 | 92,832 (0%) | 0% | 72.8 | 686,902 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 16 Mar 2026 | 60,299 | 193,180 (0%) | 0% | 60.9 | 3,671,606 | Common Stock |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Sale of securities on an exchange or to another person at price $ 76.30 per share. | 10 Mar 2026 | 16,086 | 11,714 (0%) | 0% | 76.3 | 1,227,362 | Common Stock |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Sale of securities on an exchange or to another person at price $ 75.50 per share. | 10 Mar 2026 | 21,191 | 27,800 (0%) | 0% | 75.5 | 1,599,963 | Common Stock |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 46.10 per share. | 10 Mar 2026 | 32,602 | 48,991 (0%) | 0% | 46.1 | 1,502,952 | Common Stock |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2026 | 32,602 | 32,601 | - | - | Non-Qualified Stock Option (right to buy) | |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2026 | 4,675 | 14,025 | - | - | Non-Qualified Stock Option (right to buy) | |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 34.69 per share. | 10 Mar 2026 | 4,675 | 16,389 (0%) | 0% | 34.7 | 162,176 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2026 | 34,103 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 75.58 per share. | 09 Mar 2026 | 1,684 | 242,662 (0%) | 0% | 75.6 | 127,282 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 75.26 per share. | 09 Mar 2026 | 117,604 | 244,346 (0%) | 0% | 75.3 | 8,850,642 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 74.11 per share. | 09 Mar 2026 | 7,382 | 361,950 (0%) | 0% | 74.1 | 547,087 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 09 Mar 2026 | 73,529 | 369,332 (0%) | 0% | 60.9 | 4,477,181 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 09 Mar 2026 | 40,822 | 295,803 (0%) | 0% | 60.9 | 2,485,652 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 75.47 per share. | 09 Mar 2026 | 16,512 | 260,253 (0%) | 0% | 75.5 | 1,246,235 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 76.34 per share. | 09 Mar 2026 | 17,591 | 242,662 (0%) | 0% | 76.3 | 1,342,909 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2026 | 40,822 | 107,632 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2026 | 73,529 | 34,103 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 09 Mar 2026 | 34,103 | 276,765 (0%) | 0% | 60.9 | 2,076,532 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 75.25 per share. | 09 Mar 2026 | 10,148 | 62,211 (0%) | 0% | 75.3 | 763,662 | Common Stock |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 40.05 per share. | 03 Mar 2026 | 12,000 | 28,346 (0%) | 0% | 40.1 | 480,600 | Common Stock |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 42.88 per share. | 03 Mar 2026 | 4,000 | 32,346 (0%) | 0% | 42.9 | 171,520 | Common Stock |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 79.17 per share. | 03 Mar 2026 | 13,526 | 18,820 (0%) | 0% | 79.2 | 1,070,908 | Common Stock |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 79.99 per share. | 03 Mar 2026 | 6,794 | 12,026 (0%) | 0% | 80.0 | 543,486 | Common Stock |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 80.82 per share. | 03 Mar 2026 | 1,012 | 11,014 (0%) | 0% | 80.8 | 81,788 | Common Stock |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2026 | 12,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2026 | 4,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2026 | 200 | 10,968 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2026 | 832 | 11,168 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Loscalzo | Director | Sale of securities on an exchange or to another person at price $ 80.00 per share. | 03 Mar 2026 | 200 | 36,330 (0%) | 0% | 80 | 16,000 | Common Stock |
| Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.06 per share. | 03 Mar 2026 | 200 | 36,530 (0%) | 0% | 38.1 | 7,612 | Common Stock |
| Joseph Loscalzo | Director | Sale of securities on an exchange or to another person at price $ 80.33 per share. | 03 Mar 2026 | 832 | 36,330 (0%) | 0% | 80.3 | 66,833 | Common Stock |
| Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.06 per share. | 03 Mar 2026 | 832 | 37,162 (0%) | 0% | 38.1 | 31,666 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2026 | 48,626 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 03 Mar 2026 | 16,463 | 117,017 (0%) | 0% | 32.6 | 536,694 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 03 Mar 2026 | 48,626 | 165,643 (0%) | 0% | 60.9 | 2,960,837 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 79.10 per share. | 03 Mar 2026 | 71,600 | 94,043 (0%) | 0% | 79.1 | 5,663,488 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 79.88 per share. | 03 Mar 2026 | 12,687 | 81,356 (0%) | 0% | 79.9 | 1,013,410 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 80.76 per share. | 03 Mar 2026 | 802 | 80,554 (0%) | 0% | 80.8 | 64,771 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2026 | 16,463 | 2,406 | - | - | Non-Qualified Stock Option (right to buy) | |
| Allene M. Diaz | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.06 per share. | 03 Mar 2026 | 12,000 | 40,689 (0%) | 0% | 38.1 | 456,720 | Common Stock |
| Allene M. Diaz | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2026 | 10,321 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Allene M. Diaz | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2026 | 18,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Allene M. Diaz | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2026 | 12,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Allene M. Diaz | Director | Sale of securities on an exchange or to another person at price $ 80.80 per share. | 03 Mar 2026 | 1,005 | 3,811 (0%) | 0% | 80.8 | 81,203 | Common Stock |
| Allene M. Diaz | Director | Sale of securities on an exchange or to another person at price $ 79.88 per share. | 03 Mar 2026 | 14,608 | 4,816 (0%) | 0% | 79.9 | 1,166,814 | Common Stock |
| Allene M. Diaz | Director | Sale of securities on an exchange or to another person at price $ 79.11 per share. | 03 Mar 2026 | 39,265 | 19,424 (0%) | 0% | 79.1 | 3,106,411 | Common Stock |
| Allene M. Diaz | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 40.05 per share. | 03 Mar 2026 | 18,000 | 58,689 (0%) | 0% | 40.1 | 720,900 | Common Stock |
| Allene M. Diaz | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 41.08 per share. | 03 Mar 2026 | 10,321 | 28,689 (0%) | 0% | 41.1 | 423,987 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 79.36 per share. | 03 Mar 2026 | 4,096 | 41,317 (0%) | 0% | 79.4 | 325,059 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 03 Mar 2026 | 820 | 5,592 (0%) | 0% | 56.8 | 46,560 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 03 Mar 2026 | 879 | 6,471 (0%) | 0% | 32.6 | 28,655 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 80.41 per share. | 03 Mar 2026 | 2,088 | 4,383 (0%) | 0% | 80.4 | 167,892 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 81.00 per share. | 03 Mar 2026 | 36 | 4,347 (0%) | 0% | 81 | 2,916 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 03 Mar 2026 | 238 | 4,585 (0%) | 0% | 56.8 | 13,514 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 80.00 per share. | 03 Mar 2026 | 238 | 4,347 (0%) | 0% | 80 | 19,040 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 03 Mar 2026 | 201 | 4,548 (0%) | 0% | 32.6 | 6,553 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 80.00 per share. | 03 Mar 2026 | 201 | 4,347 (0%) | 0% | 80 | 16,080 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2026 | 201 | 1,769 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2026 | 238 | 3,866 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2026 | 879 | 1,970 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2026 | 820 | 4,104 | - | - | Non-Qualified Stock Option (right to buy) | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2026 | 3,510 | 5,744 | - | - | Non-Qualified Stock Option (right to buy) | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2026 | 385 | 8,877 | - | - | Non-Qualified Stock Option (right to buy) | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2026 | 3,760 | 11,280 | - | - | Non-Qualified Stock Option (right to buy) | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2026 | 5,500 | 16,500 | - | - | Non-Qualified Stock Option (right to buy) | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2026 | 6,951 | 928 | - | - | Non-Qualified Stock Option (right to buy) | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Sale of securities on an exchange or to another person at price $ 80.84 per share. | 03 Mar 2026 | 755 | 22,541 (0%) | 0% | 80.8 | 61,032 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Sale of securities on an exchange or to another person at price $ 80.00 per share. | 03 Mar 2026 | 5,030 | 23,296 (0%) | 0% | 80.0 | 402,395 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Sale of securities on an exchange or to another person at price $ 79.12 per share. | 03 Mar 2026 | 14,321 | 28,326 (0%) | 0% | 79.1 | 1,133,006 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.87 per share. | 03 Mar 2026 | 385 | 42,647 (0%) | 0% | 52.9 | 20,355 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 03 Mar 2026 | 6,951 | 42,262 (0%) | 0% | 32.6 | 226,603 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 34.69 per share. | 03 Mar 2026 | 5,500 | 35,311 (0%) | 0% | 34.7 | 190,795 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 40.85 per share. | 03 Mar 2026 | 3,760 | 29,811 (0%) | 0% | 40.9 | 153,596 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.58 per share. | 03 Mar 2026 | 3,510 | 26,051 (0%) | 0% | 37.6 | 131,906 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Other type of transaction at price $ 48.87 per share. | 27 Feb 2026 | 261 | 100,554 (0%) | 0% | 48.9 | 12,754 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Other type of transaction at price $ 48.87 per share. | 27 Feb 2026 | 484 | 254,981 (0%) | 0% | 48.9 | 23,651 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Other type of transaction at price $ 48.87 per share. | 27 Feb 2026 | 376 | 72,359 (0%) | 0% | 48.9 | 18,374 | Common Stock |
| Eric E. Swayze | EVP Research | Other type of transaction at price $ 48.87 per share. | 27 Feb 2026 | 256 | 32,361 (0%) | 0% | 48.9 | 12,510 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Other type of transaction at price $ 48.87 per share. | 27 Feb 2026 | 351 | 66,598 (0%) | 0% | 48.9 | 17,152 | Common Stock |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 81.56 per share. | 13 Feb 2026 | 9,435 | 38,312 (0%) | 0% | 81.6 | 769,511 | Common Stock |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 82.07 per share. | 13 Feb 2026 | 6,207 | 32,105 (0%) | 0% | 82.1 | 509,403 | Common Stock |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 82.72 per share. | 11 Feb 2026 | 5,000 | 56,344 (0%) | 0% | 82.7 | 413,589 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 85.79 per share. | 06 Feb 2026 | 29,430 | 254,497 (0%) | 0% | 85.8 | 2,524,820 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 82.60 per share. | 02 Feb 2026 | 20,000 | 80,293 (0%) | 0% | 82.6 | 1,651,980 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Feb 2026 | 48,626 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Feb 2026 | 16,463 | 2,406 | - | - | Non-Qualified Stock Option (right to buy) | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 83.03 per share. | 02 Feb 2026 | 16,463 | 80,293 (0%) | 0% | 83.0 | 1,366,897 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 02 Feb 2026 | 16,463 | 96,756 (0%) | 0% | 32.6 | 536,694 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 83.03 per share. | 02 Feb 2026 | 48,626 | 80,293 (0%) | 0% | 83.0 | 4,037,339 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 02 Feb 2026 | 48,626 | 128,919 (0%) | 0% | 60.9 | 2,960,837 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2026 | 11,421 | 106,178 (0%) | 0% | 0 | Common Stock | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 82.95 per share. | 29 Jan 2026 | 5,885 | 100,293 (0%) | 0% | 82.9 | 488,141 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2026 | 122,214 | 346,897 (0%) | 0% | 0 | Common Stock | |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 82.72 per share. | 29 Jan 2026 | 62,970 | 283,927 (0%) | 0% | 82.7 | 5,208,979 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2026 | 13,562 | 139,869 (0%) | 0% | 0 | Common Stock | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Sale of securities on an exchange or to another person at price $ 83.24 per share. | 29 Jan 2026 | 6,988 | 132,881 (0%) | 0% | 83.2 | 581,702 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2026 | 11,991 | 78,162 (0%) | 0% | 0 | Common Stock | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 83.53 per share. | 29 Jan 2026 | 6,179 | 71,983 (0%) | 0% | 83.5 | 516,153 | Common Stock |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2026 | 11,991 | 53,926 (0%) | 0% | 0 | Common Stock | |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 82.93 per share. | 29 Jan 2026 | 6,179 | 47,747 (0%) | 0% | 82.9 | 512,446 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 82.96 per share. | 29 Jan 2026 | 5,296 | 45,413 (0%) | 0% | 83.0 | 439,364 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2026 | 10,278 | 50,709 (0%) | 0% | 0 | Common Stock | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2026 | 11,991 | 75,881 (0%) | 0% | 0 | Common Stock | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 83.45 per share. | 29 Jan 2026 | 6,179 | 69,702 (0%) | 0% | 83.4 | 515,630 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2026 | 11,991 | 72,426 (0%) | 0% | 0 | Common Stock | |
| Brian Birchler | EVP, Corp and Development Ops | Sale of securities on an exchange or to another person at price $ 83.03 per share. | 29 Jan 2026 | 6,179 | 66,247 (0%) | 0% | 83.0 | 513,048 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Sale of securities on an exchange or to another person at price $ 81.34 per share. | 22 Jan 2026 | 3,977 | 22,541 (0%) | 0% | 81.3 | 323,490 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 9,675 | 27,109 | - | - | Restricted Stock Unit | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 21,055 | 103,734 (0%) | 0% | 0 | Common Stock | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 75.15 per share. | 15 Jan 2026 | 8,977 | 94,757 (0%) | 0% | 75.2 | 674,622 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 25,800 | 89,282 | - | - | Performance Restricted Stock Units | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 21,055 | 17,434 | - | - | Restricted Stock Unit | |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 74.82 per share. | 15 Jan 2026 | 44,034 | 224,683 (0%) | 0% | 74.8 | 3,294,624 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 42,705 | 205,719 | - | - | Restricted Stock Unit | |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 89,145 | 163,014 | - | - | Restricted Stock Unit | |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 113,880 | 744,081 | - | - | Performance Restricted Stock Units | |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 89,145 | 268,717 (0%) | 0% | 0 | Common Stock | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 28,729 | 55,940 | - | - | Restricted Stock Unit | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 28,729 | 139,229 (0%) | 0% | 0 | Common Stock | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Sale of securities on an exchange or to another person at price $ 75.22 per share. | 15 Jan 2026 | 12,922 | 126,307 (0%) | 0% | 75.2 | 971,993 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 12,885 | 68,825 | - | - | Restricted Stock Unit | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 34,360 | 120,995 | - | - | Performance Restricted Stock Units | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 9,675 | 48,926 | - | - | Restricted Stock Unit | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 21,473 | 75,362 (0%) | 0% | 0 | Common Stock | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 75.84 per share. | 15 Jan 2026 | 9,191 | 66,171 (0%) | 0% | 75.8 | 697,045 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 25,800 | 90,601 | - | - | Performance Restricted Stock Units | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 21,473 | 39,251 | - | - | Restricted Stock Unit | |
| Michael J. Yang | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 1,930 | 7,940 (0%) | 0% | 0 | Common Stock | |
| Michael J. Yang | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 1,930 | 7,150 | - | - | Restricted Stock Unit | |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 25,800 | 44,500 | - | - | Performance Restricted Stock Units | |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 9,675 | 37,725 | - | - | Restricted Stock Unit | |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 7,013 | 29,664 | - | - | Restricted Stock Unit | |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 7,013 | 18,212 (0%) | 0% | 0 | Common Stock | |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Sale of securities on an exchange or to another person at price $ 75.96 per share. | 15 Jan 2026 | 1,823 | 16,389 (0%) | 0% | 76.0 | 138,475 | Common Stock |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 75.34 per share. | 15 Jan 2026 | 9,884 | 41,935 (0%) | 0% | 75.3 | 744,661 | Common Stock |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 225 | 611 | - | - | Restricted Stock Unit | |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 111 | 386 | - | - | Restricted Stock Unit | |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 9,675 | 48,926 | - | - | Restricted Stock Unit | |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 21,366 | 39,251 | - | - | Restricted Stock Unit | |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 25,800 | 90,282 | - | - | Performance Restricted Stock Units | |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 75.98 per share. | 15 Jan 2026 | 49 | 318 (0%) | 0% | 76.0 | 3,723 | Common Stock |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 111 | 367 (0%) | 0% | 0 | Common Stock | |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 21,366 | 51,819 (0%) | 0% | 0 | Common Stock | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 17,037 | 49,474 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 17,037 | 47,338 (0%) | 0% | 0 | Common Stock | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 75.75 per share. | 15 Jan 2026 | 6,907 | 40,431 (0%) | 0% | 75.7 | 523,205 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 2,850 | 5,921 (0%) | 0% | 0 | Common Stock | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 75.78 per share. | 15 Jan 2026 | 1,149 | 4,772 (0%) | 0% | 75.8 | 87,071 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 9,675 | 59,149 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 2,850 | 5,474 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 25,800 | 77,090 | - | - | Performance Restricted Stock Units | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 3,900 | 9,374 | - | - | Restricted Stock Unit | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 21,685 | 73,192 (0%) | 0% | 0 | Common Stock | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 75.59 per share. | 15 Jan 2026 | 9,302 | 63,890 (0%) | 0% | 75.6 | 703,138 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 25,800 | 91,237 | - | - | Performance Restricted Stock Units | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 21,685 | 39,251 | - | - | Restricted Stock Unit | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 9,675 | 48,926 | - | - | Restricted Stock Unit | |
| Brian Birchler | EVP, Corp and Development Ops | Sale of securities on an exchange or to another person at price $ 75.11 per share. | 15 Jan 2026 | 8,480 | 60,435 (0%) | 0% | 75.1 | 636,933 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 20,089 | 68,915 (0%) | 0% | 0 | Common Stock | |
| Brian Birchler | EVP, Corp and Development Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 9,675 | 50,801 | - | - | Restricted Stock Unit | |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 20,089 | 41,126 | - | - | Restricted Stock Unit | |
| Brian Birchler | EVP, Corp and Development Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 25,800 | 79,138 | - | - | Performance Restricted Stock Units | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Sale of securities on an exchange or to another person at price $ 75.95 per share. | 15 Jan 2026 | 8,353 | 26,518 (0%) | 0% | 75.9 | 634,410 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 9,675 | 52,704 | - | - | Restricted Stock Unit | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 17,377 | 43,029 | - | - | Restricted Stock Unit | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 25,800 | 47,800 | - | - | Performance Restricted Stock Units | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 17,377 | 34,871 (0%) | 0% | 0 | Common Stock | |
| Holly B. Kordasiewicz | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 13,650 | 34,480 | - | - | Restricted Stock Unit | |
| Holly B. Kordasiewicz | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2026 | 11,250 | 45,730 | - | - | Restricted Stock Unit | |
| Holly B. Kordasiewicz | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 11,119 | 20,830 | - | - | Restricted Stock Unit | |
| Holly B. Kordasiewicz | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.66 per share. | 15 Jan 2026 | 4,141 | 14,718 (0%) | 0% | 75.7 | 313,308 | Common Stock |
| Holly B. Kordasiewicz | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2026 | 11,119 | 18,859 (0%) | 0% | 0 | Common Stock | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 07 Jan 2026 | 25,545 | 43,039 (0%) | 0% | 56.8 | 1,450,445 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jan 2026 | 25,545 | 2,971 | - | - | Non-Qualified Stock Option (right to buy) | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jan 2026 | 9,264 | 9,262 | - | - | Non-Qualified Stock Option (right to buy) | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jan 2026 | 3,829 | 9,254 | - | - | Non-Qualified Stock Option (right to buy) | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jan 2026 | 3,460 | 7,879 | - | - | Non-Qualified Stock Option (right to buy) | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jan 2026 | 2,101 | 11,339 | - | - | Non-Qualified Stock Option (right to buy) | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Sale of securities on an exchange or to another person at price $ 84.62 per share. | 07 Jan 2026 | 9,264 | 17,494 (0%) | 0% | 84.6 | 783,920 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.87 per share. | 07 Jan 2026 | 9,264 | 26,758 (0%) | 0% | 52.9 | 489,788 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Sale of securities on an exchange or to another person at price $ 84.62 per share. | 07 Jan 2026 | 3,829 | 17,494 (0%) | 0% | 84.6 | 324,010 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.58 per share. | 07 Jan 2026 | 3,829 | 21,323 (0%) | 0% | 37.6 | 143,894 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Sale of securities on an exchange or to another person at price $ 84.62 per share. | 07 Jan 2026 | 3,460 | 17,494 (0%) | 0% | 84.6 | 292,785 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 07 Jan 2026 | 3,460 | 20,954 (0%) | 0% | 32.6 | 112,796 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Sale of securities on an exchange or to another person at price $ 85.36 per share. | 07 Jan 2026 | 2,101 | 17,494 (0%) | 0% | 85.4 | 179,341 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 07 Jan 2026 | 2,101 | 19,595 (0%) | 0% | 32.6 | 68,493 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Sale of securities on an exchange or to another person at price $ 85.36 per share. | 07 Jan 2026 | 25,545 | 17,494 (0%) | 0% | 85.4 | 2,180,521 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 19,350 | 19,350 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 85,410 | 85,410 | - | - | Non-Qualified Stock Option (right to buy) | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 25,770 | 25,770 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 19,350 | 19,350 | - | - | Non-Qualified Stock Option (right to buy) | |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 19,350 | 19,350 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 150 | 150 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 02 Jan 2026 | 5,125 | 35,578 (0%) | 0% | 60.9 | 312,061 | Common Stock |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 78.57 per share. | 02 Jan 2026 | 5,125 | 30,453 (0%) | 0% | 78.6 | 402,671 | Common Stock |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 02 Jan 2026 | 18,338 | 48,791 (0%) | 0% | 60.9 | 1,116,601 | Common Stock |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 79.27 per share. | 02 Jan 2026 | 18,338 | 30,453 (0%) | 0% | 79.3 | 1,453,653 | Common Stock |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2026 | 5,125 | 22,403 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2026 | 18,338 | 4,065 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 19,350 | 19,350 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 19,350 | 19,350 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 2,600 | 2,600 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 19,350 | 19,350 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brian Birchler | EVP, Corp and Development Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 19,350 | 19,350 | - | - | Non-Qualified Stock Option (right to buy) | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 19,350 | 19,350 | - | - | Non-Qualified Stock Option (right to buy) | |
| Holly B. Kordasiewicz | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 9,100 | 9,100 | - | - | Non-Qualified Stock Option (right to buy) | |
| Holly B. Kordasiewicz | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2026 | 7,500 | 16,600 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 80.67 per share. | 01 Dec 2025 | 20,571 | 43,464 (0%) | 0% | 80.7 | 1,659,362 | Common Stock |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 81.23 per share. | 01 Dec 2025 | 7,429 | 36,035 (0%) | 0% | 81.2 | 603,486 | Common Stock |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Nov 2025 | 4,000 | 4,000 (0%) | 0% | 0 | Common Stock | |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 80.00 per share. | 25 Nov 2025 | 4,000 | 0 (0%) | 0% | 80 | 320,000 | Common Stock |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Nov 2025 | 4,000 | 4,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Nov 2025 | 4,000 | 8,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Nov 2025 | 4,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 80.00 per share. | 25 Nov 2025 | 4,000 | 0 (0%) | 0% | 80 | 320,000 | Common Stock |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Nov 2025 | 4,000 | 4,000 (0%) | 0% | 0 | Common Stock | |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 80.00 per share. | 25 Nov 2025 | 4,000 | 0 (0%) | 0% | 80 | 320,000 | Common Stock |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Nov 2025 | 4,000 | 4,000 (0%) | 0% | 0 | Common Stock | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Sale of securities on an exchange or to another person at price $ 80.91 per share. | 25 Nov 2025 | 16,777 | 17,494 (0%) | 0% | 80.9 | 1,357,442 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 25 Nov 2025 | 16,777 | 34,271 (0%) | 0% | 53.8 | 902,099 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Nov 2025 | 16,777 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joan E. Herman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 40.05 per share. | 19 Nov 2025 | 12,000 | 58,086 (0%) | 0% | 40.1 | 480,600 | Common Stock |
| Joan E. Herman | Director | Sale of securities on an exchange or to another person at price $ 72.13 per share. | 19 Nov 2025 | 32,000 | 46,086 (0%) | 0% | 72.1 | 2,308,240 | Common Stock |
| Joan E. Herman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.90 per share. | 19 Nov 2025 | 32,000 | 78,086 (0%) | 0% | 63.9 | 2,044,800 | Common Stock |
| Joan E. Herman | Director | Sale of securities on an exchange or to another person at price $ 72.13 per share. | 19 Nov 2025 | 12,000 | 46,086 (0%) | 0% | 72.1 | 865,590 | Common Stock |
| Joan E. Herman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Nov 2025 | 32,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joan E. Herman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Nov 2025 | 12,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph H. Wender | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.42 per share. | 18 Nov 2025 | 16,000 | 16,000 (0%) | 0% | 24.4 | 390,720 | Common Stock |
| Joseph H. Wender | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Nov 2025 | 16,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brian Birchler | EVP, Corp and Development Ops | Sale of securities on an exchange or to another person at price $ 76.17 per share. | 06 Nov 2025 | 8,000 | 48,826 (0%) | 0% | 76.2 | 609,379 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 76.10 per share. | 05 Nov 2025 | 14,738 | 59,657 (0%) | 0% | 76.1 | 1,121,521 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 05 Nov 2025 | 14,738 | 74,395 (0%) | 0% | 56.8 | 836,824 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.01 per share. | 05 Nov 2025 | 801 | 59,657 (0%) | 0% | 75.0 | 60,083 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 05 Nov 2025 | 801 | 60,458 (0%) | 0% | 60.9 | 48,773 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.01 per share. | 05 Nov 2025 | 800 | 59,657 (0%) | 0% | 75.0 | 60,008 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 05 Nov 2025 | 800 | 60,457 (0%) | 0% | 56.8 | 45,424 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Nov 2025 | 18,300 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Nov 2025 | 801 | 18,300 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Nov 2025 | 14,738 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Nov 2025 | 800 | 14,738 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 05 Nov 2025 | 18,300 | 77,957 (0%) | 0% | 60.9 | 1,114,287 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.42 per share. | 05 Nov 2025 | 18,300 | 59,657 (0%) | 0% | 75.4 | 1,380,204 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.05 per share. | 03 Nov 2025 | 905 | 59,657 (0%) | 0% | 75.1 | 67,924 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Nov 2025 | 905 | 15,538 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 03 Nov 2025 | 905 | 60,562 (0%) | 0% | 56.8 | 51,386 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.05 per share. | 03 Nov 2025 | 775 | 59,657 (0%) | 0% | 75.1 | 58,167 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Nov 2025 | 775 | 19,101 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 03 Nov 2025 | 775 | 60,432 (0%) | 0% | 60.9 | 47,190 | Common Stock |
| Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.22 per share. | 31 Oct 2025 | 16,000 | 52,330 (0%) | 0% | 52.2 | 835,520 | Common Stock |
| Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Oct 2025 | 16,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Loscalzo | Director | Sale of securities on an exchange or to another person at price $ 75.10 per share. | 31 Oct 2025 | 16,000 | 36,330 (0%) | 0% | 75.1 | 1,201,669 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Oct 2025 | 34,585 | 19,876 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Oct 2025 | 34,664 | 16,443 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.05 per share. | 31 Oct 2025 | 905 | 59,657 (0%) | 0% | 75.1 | 67,924 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 31 Oct 2025 | 905 | 60,562 (0%) | 0% | 60.9 | 55,105 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.05 per share. | 31 Oct 2025 | 775 | 59,657 (0%) | 0% | 75.1 | 58,167 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 31 Oct 2025 | 775 | 60,432 (0%) | 0% | 56.8 | 44,005 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.11 per share. | 31 Oct 2025 | 20,000 | 59,657 (0%) | 0% | 75.1 | 1,502,166 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.11 per share. | 31 Oct 2025 | 34,664 | 79,657 (0%) | 0% | 75.1 | 2,603,554 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 31 Oct 2025 | 34,664 | 114,321 (0%) | 0% | 56.8 | 1,968,222 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.11 per share. | 31 Oct 2025 | 34,585 | 79,657 (0%) | 0% | 75.1 | 2,597,621 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 31 Oct 2025 | 34,585 | 114,242 (0%) | 0% | 60.9 | 2,105,881 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Oct 2025 | 905 | 18,971 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Oct 2025 | 775 | 15,668 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 73.16 per share. | 30 Oct 2025 | 8,341 | 81,210 (0%) | 0% | 73.2 | 610,228 | Common Stock |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 72.19 per share. | 30 Oct 2025 | 2,484 | 89,551 (0%) | 0% | 72.2 | 179,320 | Common Stock |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 75.16 per share. | 30 Oct 2025 | 11,200 | 64,035 (0%) | 0% | 75.2 | 841,776 | Common Stock |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 73.85 per share. | 30 Oct 2025 | 5,975 | 75,235 (0%) | 0% | 73.9 | 441,254 | Common Stock |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 71.74 per share. | 15 Oct 2025 | 5,000 | 61,344 (0%) | 0% | 71.7 | 358,722 | Common Stock |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2025 | 125 | 497 | - | - | Restricted Stock Unit | |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 73.62 per share. | 15 Oct 2025 | 53 | 256 (0%) | 0% | 73.6 | 3,902 | Common Stock |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2025 | 125 | 309 (0%) | 0% | 0 | Common Stock | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 48.51 per share. | 15 Oct 2025 | 6,000 | 21,937 (0%) | 0% | 48.5 | 291,060 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2025 | 2,820 | 60,406 | - | - | Restricted Stock Unit | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2025 | 6,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Sale of securities on an exchange or to another person at price $ 73.62 per share. | 15 Oct 2025 | 1,263 | 17,494 (0%) | 0% | 73.6 | 92,984 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2025 | 2,820 | 18,757 (0%) | 0% | 0 | Common Stock | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Sale of securities on an exchange or to another person at price $ 72.94 per share. | 15 Oct 2025 | 6,000 | 15,937 (0%) | 0% | 72.9 | 437,654 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2025 | 12,425 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2025 | 11,475 | 12,425 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brian Birchler | EVP, Corp and Development Ops | Sale of securities on an exchange or to another person at price $ 72.23 per share. | 14 Oct 2025 | 12,425 | 56,826 (0%) | 0% | 72.2 | 897,398 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 14 Oct 2025 | 12,425 | 69,251 (0%) | 0% | 53.8 | 668,092 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Sale of securities on an exchange or to another person at price $ 72.03 per share. | 14 Oct 2025 | 11,475 | 56,826 (0%) | 0% | 72.0 | 826,589 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 14 Oct 2025 | 11,475 | 68,301 (0%) | 0% | 53.8 | 617,011 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 69.26 per share. | 06 Oct 2025 | 437 | 179,572 (0%) | 0% | 69.3 | 30,268 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.87 per share. | 06 Oct 2025 | 10,200 | 67,330 (0%) | 0% | 52.9 | 539,274 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 69.89 per share. | 06 Oct 2025 | 10,200 | 57,130 (0%) | 0% | 69.9 | 712,849 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 69.27 per share. | 06 Oct 2025 | 3,241 | 53,889 (0%) | 0% | 69.3 | 224,488 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Oct 2025 | 10,200 | 17,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 69.02 per share. | 06 Oct 2025 | 6,849 | 30,453 (0%) | 0% | 69.0 | 472,718 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 69.37 per share. | 06 Oct 2025 | 1,625 | 30,301 (0%) | 0% | 69.4 | 112,725 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 67.69 per share. | 02 Oct 2025 | 30,203 | 57,130 (0%) | 0% | 67.7 | 2,044,417 | Common Stock |
| R. Patrick O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 67.69 per share. | 02 Oct 2025 | 34,461 | 57,130 (0%) | 0% | 67.7 | 2,332,638 | Common Stock |
| O'Neil R. Patrick | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Oct 2025 | 30,203 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Baroldi Joseph T. | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.80 per share. | 02 Oct 2025 | 15,000 | 46,926 (0%) | 0% | 31.8 | 477,000 | Common Stock |
| Patrick O'Neil R. | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Oct 2025 | 34,461 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| O'Neil R. Patrick | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 02 Oct 2025 | 30,203 | 87,333 (0%) | 0% | 56.8 | 1,714,926 | Common Stock |
| Joseph Baroldi T. | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Oct 2025 | 15,000 | 26,700 | - | - | Non-Qualified Stock Option (right to buy) | |
| R. Patrick O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 02 Oct 2025 | 34,461 | 91,591 (0%) | 0% | 60.9 | 2,098,330 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 68.01 per share. | 02 Oct 2025 | 15,000 | 31,926 (0%) | 0% | 68.0 | 1,020,210 | Common Stock |
| Swayze Eric E. | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2025 | 12,972 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 66.09 per share. | 01 Oct 2025 | 14,142 | 37,302 (0%) | 0% | 66.1 | 934,662 | Common Stock |
| E. Eric Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 66.23 per share. | 01 Oct 2025 | 12,972 | 37,302 (0%) | 0% | 66.2 | 859,082 | Common Stock |
| Wender Joseph H. | Director | Sale of securities on an exchange or to another person at price $ 65.50 per share. | 01 Oct 2025 | 16,800 | 92,035 (0%) | 0% | 65.5 | 1,100,385 | Common Stock |
| Swayze Eric E. | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 01 Oct 2025 | 12,972 | 50,274 (0%) | 0% | 53.8 | 697,504 | Common Stock |
| E. Eric Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 01 Oct 2025 | 14,142 | 51,444 (0%) | 0% | 53.8 | 760,415 | Common Stock |
| Swayze Eric E. | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2025 | 14,142 | 12,972 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 30 Sep 2025 | 57,900 | 137,557 (0%) | 0% | 53.8 | 3,113,283 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Sep 2025 | 57,900 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 65.24 per share. | 30 Sep 2025 | 57,900 | 79,657 (0%) | 0% | 65.2 | 3,777,668 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 30 Sep 2025 | 49,800 | 160,300 (0%) | 0% | 53.8 | 2,677,746 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Sale of securities on an exchange or to another person at price $ 65.26 per share. | 30 Sep 2025 | 49,800 | 110,500 (0%) | 0% | 65.3 | 3,249,734 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Sep 2025 | 49,800 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Sep 2025 | 14,827 | 30,203 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 64.54 per share. | 29 Sep 2025 | 10,473 | 57,130 (0%) | 0% | 64.5 | 675,945 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 29 Sep 2025 | 10,473 | 67,603 (0%) | 0% | 56.8 | 594,657 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 29 Sep 2025 | 14,827 | 71,957 (0%) | 0% | 56.8 | 841,877 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Sep 2025 | 10,473 | 45,030 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 64.68 per share. | 29 Sep 2025 | 14,827 | 57,130 (0%) | 0% | 64.7 | 958,976 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 64.58 per share. | 12 Sep 2025 | 1,700 | 57,130 (0%) | 0% | 64.6 | 109,787 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Sep 2025 | 1,700 | 55,503 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 12 Sep 2025 | 1,700 | 58,830 (0%) | 0% | 56.8 | 96,526 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.89 per share. | 09 Sep 2025 | 20,000 | 77,130 (0%) | 0% | 60.9 | 1,217,800 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Sep 2025 | 20,000 | 34,461 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Sep 2025 | 1,000 | 57,203 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 64.56 per share. | 09 Sep 2025 | 1,000 | 57,130 (0%) | 0% | 64.6 | 64,555 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 56.78 per share. | 09 Sep 2025 | 1,000 | 58,130 (0%) | 0% | 56.8 | 56,780 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 64.56 per share. | 09 Sep 2025 | 20,000 | 57,130 (0%) | 0% | 64.6 | 1,291,106 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.80 per share. | 09 Sep 2025 | 11,950 | 43,876 (0%) | 0% | 31.8 | 380,010 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 62.16 per share. | 09 Sep 2025 | 11,950 | 31,926 (0%) | 0% | 62.2 | 742,838 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Sep 2025 | 11,950 | 41,700 | - | - | Non-Qualified Stock Option (right to buy) | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 59.60 per share. | 05 Sep 2025 | 6,000 | 82,679 (0%) | 0% | 59.6 | 357,581 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.80 per share. | 05 Sep 2025 | 250 | 32,176 (0%) | 0% | 31.8 | 7,950 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 62.00 per share. | 05 Sep 2025 | 250 | 31,926 (0%) | 0% | 62 | 15,500 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Sep 2025 | 250 | 53,650 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 60.00 per share. | 03 Sep 2025 | 28,000 | 0 (0%) | 0% | 60 | 1,680,000 | Common Stock |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 16,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 12,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 60.00 per share. | 03 Sep 2025 | 28,000 | 0 (0%) | 0% | 60 | 1,680,000 | Common Stock |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 12,000 | 28,000 (0%) | 0% | 0 | Common Stock | |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 16,000 | 16,000 (0%) | 0% | 0 | Common Stock | |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 16,000 | 16,000 (0%) | 0% | 0 | Common Stock | |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 12,000 | 28,000 (0%) | 0% | 0 | Common Stock | |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 16,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 12,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.42 per share. | 03 Sep 2025 | 16,000 | 52,330 (0%) | 0% | 24.4 | 390,720 | Common Stock |
| Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 16,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Loscalzo | Director | Sale of securities on an exchange or to another person at price $ 60.15 per share. | 03 Sep 2025 | 16,000 | 36,330 (0%) | 0% | 60.1 | 962,371 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.58 per share. | 03 Sep 2025 | 42,030 | 308,324 (0%) | 0% | 37.6 | 1,579,487 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 03 Sep 2025 | 102,900 | 282,909 (0%) | 0% | 53.8 | 5,532,933 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 102,900 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 42,030 | 76,643 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 27,568 | 40,173 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 31,316 | 67,741 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 61.06 per share. | 03 Sep 2025 | 59,699 | 180,009 (0%) | 0% | 61.1 | 3,645,394 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 03 Sep 2025 | 27,568 | 239,708 (0%) | 0% | 32.6 | 898,717 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 03 Sep 2025 | 31,316 | 212,140 (0%) | 0% | 32.6 | 1,020,902 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 60.13 per share. | 03 Sep 2025 | 127,500 | 180,824 (0%) | 0% | 60.1 | 7,667,047 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 59.12 per share. | 03 Sep 2025 | 16,615 | 266,294 (0%) | 0% | 59.1 | 982,262 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 15,000 | 68,900 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 15,000 | 53,900 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.80 per share. | 03 Sep 2025 | 2,800 | 34,726 (0%) | 0% | 31.8 | 89,040 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 62.01 per share. | 03 Sep 2025 | 2,800 | 31,926 (0%) | 0% | 62.0 | 173,628 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.80 per share. | 03 Sep 2025 | 15,000 | 46,926 (0%) | 0% | 31.8 | 477,000 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 59.09 per share. | 03 Sep 2025 | 30,000 | 16,926 (0%) | 0% | 59.1 | 1,772,592 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 2,800 | 83,900 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.80 per share. | 03 Sep 2025 | 15,000 | 31,926 (0%) | 0% | 31.8 | 477,000 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 19,658 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 61.42 per share. | 03 Sep 2025 | 7,203 | 51,507 (0%) | 0% | 61.4 | 442,382 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 60.46 per share. | 03 Sep 2025 | 12,455 | 58,710 (0%) | 0% | 60.5 | 753,039 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 03 Sep 2025 | 19,658 | 71,165 (0%) | 0% | 53.8 | 1,057,011 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Sale of securities on an exchange or to another person at price $ 61.02 per share. | 03 Sep 2025 | 3,162 | 15,009 (0%) | 0% | 61.0 | 192,943 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 928 | 13,440 | - | - | Non-Qualified Stock Option (right to buy) | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 2,234 | 13,083 | - | - | Non-Qualified Stock Option (right to buy) | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.58 per share. | 03 Sep 2025 | 2,234 | 18,171 (0%) | 0% | 37.6 | 83,954 | Common Stock |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 03 Sep 2025 | 928 | 15,937 (0%) | 0% | 32.6 | 30,253 | Common Stock |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 02 Sep 2025 | 10,750 | 75,594 (0%) | 0% | 50.4 | 542,015 | Common Stock |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 51.49 per share. | 02 Sep 2025 | 9,250 | 66,344 (0%) | 0% | 51.5 | 476,283 | Common Stock |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 60.14 per share. | 02 Sep 2025 | 11,200 | 108,835 (0%) | 0% | 60.1 | 673,549 | Common Stock |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 55.04 per share. | 02 Sep 2025 | 11,200 | 125,635 (0%) | 0% | 55.0 | 616,432 | Common Stock |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 55.04 per share. | 02 Sep 2025 | 11,200 | 125,635 (0%) | 0% | 55.0 | 616,432 | Common Stock |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 57.53 per share. | 02 Sep 2025 | 5,600 | 120,035 (0%) | 0% | 57.5 | 322,174 | Common Stock |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 60.14 per share. | 02 Sep 2025 | 11,200 | 108,835 (0%) | 0% | 60.1 | 673,549 | Common Stock |
| Joseph H. Wender | Director | Sale of securities on an exchange or to another person at price $ 57.53 per share. | 02 Sep 2025 | 5,600 | 120,035 (0%) | 0% | 57.5 | 322,174 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 50.37 per share. | 02 Sep 2025 | 10,000 | 79,657 (0%) | 0% | 50.4 | 503,671 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 02 Sep 2025 | 46,800 | 135,479 (0%) | 0% | 53.8 | 2,516,436 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 49.14 per share. | 02 Sep 2025 | 5,000 | 88,679 (0%) | 0% | 49.1 | 245,700 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 46,800 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 61.50 per share. | 02 Sep 2025 | 12,891 | 88,679 (0%) | 0% | 61.5 | 792,797 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 60.62 per share. | 02 Sep 2025 | 33,909 | 101,570 (0%) | 0% | 60.6 | 2,055,564 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 14,000 | 8,942 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 49,800 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 13,050 | 4,467 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2025 | 13,050 | 17,517 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 02 Sep 2025 | 49,800 | 57,130 (0%) | 0% | 53.8 | 2,677,746 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 61.42 per share. | 02 Sep 2025 | 11,375 | 7,330 (0%) | 0% | 61.4 | 698,653 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 02 Sep 2025 | 13,050 | 18,705 (0%) | 0% | 32.6 | 425,430 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 60.89 per share. | 02 Sep 2025 | 65,475 | 5,655 (0%) | 0% | 60.9 | 3,986,773 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.58 per share. | 02 Sep 2025 | 14,000 | 71,130 (0%) | 0% | 37.6 | 526,120 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 54.51 per share. | 02 Sep 2025 | 13,050 | 57,130 (0%) | 0% | 54.5 | 711,418 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 02 Sep 2025 | 13,050 | 70,180 (0%) | 0% | 32.6 | 425,430 | Common Stock |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 53.68 per share. | 02 Sep 2025 | 1,130 | 37,302 (0%) | 0% | 53.7 | 60,662 | Common Stock |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 49.22 per share. | 02 Sep 2025 | 10,000 | 38,432 (0%) | 0% | 49.2 | 492,200 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Other type of transaction at price $ 27.71 per share. | 29 Aug 2025 | 165 | 89,657 (0%) | 0% | 27.7 | 4,572 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Other type of transaction at price $ 27.71 per share. | 29 Aug 2025 | 213 | 93,679 (0%) | 0% | 27.7 | 5,902 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Other type of transaction at price $ 27.71 per share. | 29 Aug 2025 | 189 | 180,009 (0%) | 0% | 27.7 | 5,237 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Other type of transaction at price $ 27.71 per share. | 29 Aug 2025 | 331 | 57,130 (0%) | 0% | 27.7 | 9,172 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Other type of transaction at price $ 27.71 per share. | 29 Aug 2025 | 166 | 56,826 (0%) | 0% | 27.7 | 4,600 | Common Stock |
| Allene M. Diaz | Director | Sale of securities on an exchange or to another person at price $ 42.53 per share. | 22 Aug 2025 | 1,427 | 18,368 (0%) | 0% | 42.5 | 60,687 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 18 Aug 2025 | 10,000 | 103,466 (0%) | 0% | 32.6 | 326,000 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Aug 2025 | 10,000 | 18,869 | - | - | Non-Qualified Stock Option (right to buy) | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 43.98 per share. | 18 Aug 2025 | 10,000 | 93,466 (0%) | 0% | 44.0 | 439,776 | Common Stock |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 41.87 per share. | 06 Aug 2025 | 4,600 | 86,744 (0%) | 0% | 41.9 | 192,595 | Common Stock |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 42.63 per share. | 06 Aug 2025 | 400 | 86,344 (0%) | 0% | 42.6 | 17,051 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 42.86 per share. | 05 Aug 2025 | 10,000 | 89,492 (0%) | 0% | 42.9 | 428,593 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 42.80 per share. | 04 Aug 2025 | 9,549 | 51,507 (0%) | 0% | 42.8 | 408,701 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 30 Jul 2025 | 2,432 | 182,252 (0%) | 0% | 32.6 | 79,283 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2025 | 2,432 | 99,057 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 30 Jul 2025 | 2,432 | 179,820 (0%) | 0% | 45 | 109,440 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 91,344 (0%) | 0% | 0 | Common Stock | |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 5,220 | - | - | Restricted Stock Unit | |
| Joseph H. Wender | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 136,835 (0%) | 0% | 0 | Common Stock | |
| Joseph H. Wender | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 1,141 | - | - | Restricted Stock Unit | |
| Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 36,330 (0%) | 0% | 0 | Common Stock | |
| Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 5,220 | - | - | Restricted Stock Unit | |
| Joan E. Herman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 46,086 (0%) | 0% | 0 | Common Stock | |
| Joan E. Herman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 5,220 | - | - | Restricted Stock Unit | |
| Spencer R. Berthelsen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 156,013 (0%) | 0% | 0 | Common Stock | |
| Spencer R. Berthelsen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 5,220 | - | - | Restricted Stock Unit | |
| Michael Hayden | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 54,298 (0%) | 0% | 0 | Common Stock | |
| Michael Hayden | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 9,897 | - | - | Restricted Stock Unit | |
| Michael J. Yang | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 9,080 | - | - | Restricted Stock Unit | |
| Michael J. Yang | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 6,010 (0%) | 0% | 0 | Common Stock | |
| Allene M. Diaz | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 5,220 | - | - | Restricted Stock Unit | |
| Allene M. Diaz | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 19,795 (0%) | 0% | 0 | Common Stock | |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 41.74 per share. | 11 Jul 2025 | 1,160 | 179,820 (0%) | 0% | 41.7 | 48,416 | Common Stock |
| B. Lynne Parshall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 11,518 | 11,518 | - | - | Non-Qualified Stock Option (right to buy) | |
| B. Lynne Parshall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 5,220 | 9,299 | - | - | Restricted Stock Unit | |
| Joseph H. Wender | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 11,518 | 11,518 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph H. Wender | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 5,220 | 9,299 | - | - | Restricted Stock Unit | |
| Joseph Klein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 5,220 | 13,976 | - | - | Restricted Stock Unit | |
| Joseph Klein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 11,518 | 11,518 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Loscalzo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 5,220 | 9,299 | - | - | Restricted Stock Unit | |
| Joseph Loscalzo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 11,518 | 11,518 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joan E. Herman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 5,220 | 9,299 | - | - | Restricted Stock Unit | |
| Joan E. Herman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 11,518 | 11,518 | - | - | Non-Qualified Stock Option (right to buy) | |
| Spencer R. Berthelsen | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 11,518 | 11,518 | - | - | Non-Qualified Stock Option (right to buy) | |
| Spencer R. Berthelsen | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 5,220 | 9,299 | - | - | Restricted Stock Unit | |
| Michael Hayden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 5,220 | 13,976 | - | - | Restricted Stock Unit | |
| Michael Hayden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 11,518 | 11,518 | - | - | Non-Qualified Stock Option (right to buy) | |
| Michael J. Yang | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 5,220 | 13,159 | - | - | Restricted Stock Unit | |
| Michael J. Yang | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 11,518 | 11,518 | - | - | Non-Qualified Stock Option (right to buy) | |
| Allene M. Diaz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 5,220 | 9,299 | - | - | Restricted Stock Unit | |
| Allene M. Diaz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 11,518 | 11,518 | - | - | Non-Qualified Stock Option (right to buy) | |
| Michael Hayden | Director | Purchase of securities on an exchange or from another person at price $ 31.86 per share. | 01 May 2025 | 15,000 | 50,219 (0%) | 0% | 31.9 | 477,900 | Common Stock |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Sale of securities on an exchange or to another person at price $ 28.36 per share. | 15 Apr 2025 | 3,016 | 11,199 (0%) | 0% | 28.4 | 85,534 | Common Stock |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2025 | 12,226 | 14,215 (0%) | 0% | 0 | Common Stock | |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2025 | 12,226 | 36,677 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2025 | 10,837 | 66,511 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 28.40 per share. | 15 Apr 2025 | 3,928 | 31,926 (0%) | 0% | 28.4 | 111,555 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2025 | 10,837 | 35,854 (0%) | 0% | 0 | Common Stock | |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2025 | 1,875 | 61,215 | - | - | Restricted Stock Unit | |
| Brian Birchler | EVP, Corp and Development Ops | Sale of securities on an exchange or to another person at price $ 28.37 per share. | 15 Apr 2025 | 680 | 56,660 (0%) | 0% | 28.4 | 19,292 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2025 | 1,875 | 57,340 (0%) | 0% | 0 | Common Stock | |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 32.32 per share. | 11 Mar 2025 | 140 | 180,980 (0%) | 0% | 32.3 | 4,525 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Other type of transaction at price $ 28.21 per share. | 28 Feb 2025 | 554 | 56,799 (0%) | 0% | 28.2 | 15,629 | Common Stock |
| Eric E. Swayze | EVP Research | Other type of transaction at price $ 28.21 per share. | 28 Feb 2025 | 415 | 48,432 (0%) | 0% | 28.2 | 11,708 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Other type of transaction at price $ 28.21 per share. | 28 Feb 2025 | 414 | 55,465 (0%) | 0% | 28.2 | 11,680 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Other type of transaction at price $ 28.21 per share. | 28 Feb 2025 | 415 | 99,492 (0%) | 0% | 28.2 | 11,708 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Other type of transaction at price $ 28.21 per share. | 28 Feb 2025 | 320 | 93,466 (0%) | 0% | 28.2 | 9,028 | Common Stock |