XNAS 24 Apr, 2026 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Donald P. Lehr | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Apr 2026 | 358,000 | 358,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Donald P. Lehr | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Apr 2026 | 107,000 | 107,000 | - | - | Restricted Stock Units | |
| Helen Sabzevari | President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Apr 2026 | 1,366,000 | 1,366,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Helen Sabzevari | President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Apr 2026 | 410,000 | 410,000 | - | - | Restricted Stock Units | |
| Harry Thomasian | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Apr 2026 | 399,000 | 399,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Harry Thomasian | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Apr 2026 | 120,000 | 120,000 | - | - | Restricted Stock Units | |
| Rutul R. Shah | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Apr 2026 | 395,000 | 395,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Rutul R. Shah | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Apr 2026 | 118,000 | 118,000 | - | - | Restricted Stock Units | |
| Phil Tennant | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Apr 2026 | 385,000 | 385,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Phil Tennant | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Apr 2026 | 115,000 | 115,000 | - | - | Restricted Stock Units | |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 3.30 per share. | 26 Mar 2026 | 50,797 | 426,695 (0%) | 0% | 3.3 | 167,630 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 3.30 per share. | 26 Mar 2026 | 1,108,998 | 80,672,818 (47%) | 0% | 3.3 | 3,659,693 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 3.30 per share. | 26 Mar 2026 | 2,334,420 | 12,262,741 (7%) | 1% | 3.3 | 7,703,586 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 3.30 per share. | 26 Mar 2026 | 23,789 | 423,984 (0%) | 0% | 3.3 | 78,504 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 3.30 per share. | 26 Mar 2026 | 38,976 | 302,213 (0%) | 0% | 3.3 | 128,621 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 3.30 per share. | 26 Mar 2026 | 47,101 | 519,061 (0%) | 0% | 3.3 | 155,433 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 3.30 per share. | 26 Mar 2026 | 168,794 | 1,425,544 (0%) | 0% | 3.3 | 557,020 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 3.30 per share. | 26 Mar 2026 | 426,199 | 3,358,917 (1%) | 0% | 3.3 | 1,406,457 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 3.30 per share. | 26 Mar 2026 | 50,797 | 425,732 (0%) | 0% | 3.3 | 167,630 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 3.30 per share. | 26 Mar 2026 | 152,063 | 1,463,571 (0%) | 0% | 3.3 | 501,808 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 3.30 per share. | 26 Mar 2026 | 370,847 | 3,238,210 (1%) | 0% | 3.3 | 1,223,795 | Common Stock |
| Donald P. Lehr | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Mar 2026 | 40,443 | 722,092 (0%) | 0% | - | Common Stock | |
| Donald P. Lehr | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Mar 2026 | 40,443 | 0 | - | - | Restricted Stock Units | |
| Donald P. Lehr | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Mar 2026 | 40,443 | 40,443 | - | - | Restricted Stock Units | |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Mar 2026 | 321,100 | 0 | - | - | Restricted Stock Units | |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Mar 2026 | 321,100 | 3,638,122 (2%) | 0% | - | Common Stock | |
| Helen Sabzevari | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Mar 2026 | 321,100 | 321,100 | - | - | Restricted Stock Units | |
| Harry Thomasian | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Mar 2026 | 40,293 | 40,293 | - | - | Restricted Stock Units | |
| Harry Thomasian | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Mar 2026 | 40,293 | 0 | - | - | Restricted Stock Units | |
| Harry Thomasian | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Mar 2026 | 40,293 | 508,919 (0%) | 0% | - | Common Stock | |
| Rutul R. Shah | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Mar 2026 | 44,495 | 0 | - | - | Restricted Stock Units | |
| Rutul R. Shah | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Mar 2026 | 44,495 | 44,495 | - | - | Restricted Stock Units | |
| Rutul R. Shah | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Mar 2026 | 44,495 | 450,454 (0%) | 0% | - | Common Stock | |
| Phil Tennant | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Mar 2026 | 42,110 | 0 | - | - | Restricted Stock Units | |
| Phil Tennant | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Mar 2026 | 42,110 | 107,141 (0%) | 0% | - | Common Stock | |
| Phil Tennant | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Mar 2026 | 42,110 | 42,110 | - | - | Restricted Stock Units | |
| Fred Hassan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2026 | 71,839 | 1,243,239 (0%) | 0% | - | Common Stock | |
| Fred Hassan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2026 | 71,839 | 0 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2026 | 71,839 | 202,100 (0%) | 0% | - | Common Stock | |
| Jeffrey B. Kindler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2026 | 71,839 | 0 | - | - | Restricted Stock Units | |
| Nancy Howell Agee | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2026 | 71,839 | 305,776 (0%) | 0% | - | Common Stock | |
| Nancy Howell Agee | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2026 | 71,839 | 0 | - | - | Restricted Stock Units | |
| Randal J. Kirk | Director, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2026 | 143,678 | 0 | - | - | Restricted Stock Units | |
| Randal J. Kirk | Director, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2026 | 143,678 | 81,781,816 (48%) | 0% | 0 | Common Stock | |
| Cesar L. Alvarez | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2026 | 71,839 | 0 | - | - | Restricted Stock Units | |
| Cesar L. Alvarez | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2026 | 71,839 | 782,909 (0%) | 0% | - | Common Stock | |
| James S. Turley | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2026 | 71,839 | 685,417 (0%) | 0% | - | Common Stock | |
| James S. Turley | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2026 | 71,839 | 0 | - | - | Restricted Stock Units | |
| Steven Frank | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2026 | 71,839 | 1,226,391 (0%) | 0% | - | Common Stock | |
| Steven Frank | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2026 | 71,839 | 0 | - | - | Restricted Stock Units | |
| Vinita D. Gupta | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2026 | 71,839 | 0 | - | - | Restricted Stock Units | |
| Vinita D. Gupta | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2026 | 71,839 | 666,027 (0%) | 0% | - | Common Stock | |
| Fred Hassan | Director | Grant, award, or other acquisition of securities at price $ 3.51 per share. | 10 Mar 2026 | 17,948 | 1,171,400 (0%) | 0% | 3.5 | 62,997 | Common Stock |
| Fred Hassan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 41,073 | 41,073 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Fred Hassan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 35,612 | 35,612 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Grant, award, or other acquisition of securities at price $ 3.51 per share. | 10 Mar 2026 | 19,658 | 130,261 (0%) | 0% | 3.5 | 69,000 | Common Stock |
| Jeffrey B. Kindler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 35,612 | 35,612 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 41,073 | 41,073 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Nancy Howell Agee | Director | Grant, award, or other acquisition of securities at price $ 3.51 per share. | 10 Mar 2026 | 16,096 | 233,937 (0%) | 0% | 3.5 | 56,497 | Common Stock |
| Nancy Howell Agee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 35,612 | 35,612 | - | - | Restricted Stock Units | |
| Nancy Howell Agee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 41,073 | 41,073 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Randal J. Kirk | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 82,147 | 82,147 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Randal J. Kirk | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 71,225 | 71,225 | - | - | Restricted Stock Units | |
| Randal J. Kirk | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 3.51 per share. | 10 Mar 2026 | 28,490 | 81,638,138 (48%) | 0% | 3.5 | 100,000 | Common Stock |
| Cesar L. Alvarez | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 41,073 | 41,073 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Cesar L. Alvarez | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 35,612 | 35,612 | - | - | Restricted Stock Units | |
| Cesar L. Alvarez | Director | Grant, award, or other acquisition of securities at price $ 3.51 per share. | 10 Mar 2026 | 17,806 | 711,070 (0%) | 0% | 3.5 | 62,499 | Common Stock |
| James S. Turley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 41,073 | 41,073 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| James S. Turley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 35,612 | 35,612 | - | - | Restricted Stock Units | |
| James S. Turley | Director | Grant, award, or other acquisition of securities at price $ 3.51 per share. | 10 Mar 2026 | 17,806 | 613,578 (0%) | 0% | 3.5 | 62,499 | Common Stock |
| Steven Frank | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 35,612 | 35,612 | - | - | Restricted Stock Units | |
| Steven Frank | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 41,073 | 41,073 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Steven Frank | Director | Grant, award, or other acquisition of securities at price $ 3.51 per share. | 10 Mar 2026 | 14,245 | 1,154,552 (0%) | 0% | 3.5 | 50,000 | Common Stock |
| Vinita D. Gupta | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 41,073 | 41,073 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Vinita D. Gupta | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2026 | 35,612 | 35,612 | - | - | Restricted Stock Units | |
| Vinita D. Gupta | Director | Grant, award, or other acquisition of securities at price $ 3.51 per share. | 10 Mar 2026 | 17,948 | 594,188 (0%) | 0% | 3.5 | 62,997 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 4.18 per share. | 22 Dec 2025 | 956,200 | 4,598,044 (2%) | 0% | 4.2 | 3,996,916 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 4.18 per share. | 22 Dec 2025 | 5,958 | 447,773 (0%) | 0% | 4.2 | 24,904 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 4.18 per share. | 22 Dec 2025 | 9,931 | 341,189 (0%) | 0% | 4.2 | 41,512 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 4.18 per share. | 22 Dec 2025 | 11,917 | 566,162 (0%) | 0% | 4.2 | 49,813 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 4.18 per share. | 22 Dec 2025 | 42,702 | 1,594,338 (0%) | 0% | 4.2 | 178,494 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 4.18 per share. | 22 Dec 2025 | 159,321 | 3,785,116 (2%) | 0% | 4.2 | 665,962 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 4.18 per share. | 22 Dec 2025 | 12,909 | 476,529 (0%) | 0% | 4.2 | 53,960 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 4.18 per share. | 22 Dec 2025 | 38,729 | 1,615,634 (0%) | 0% | 4.2 | 161,887 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 4.18 per share. | 22 Dec 2025 | 94,341 | 3,609,057 (2%) | 0% | 4.2 | 394,345 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 4.18 per share. | 22 Dec 2025 | 12,909 | 477,492 (0%) | 0% | 4.2 | 53,960 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 4.18 per share. | 22 Dec 2025 | 555,119 | 81,609,648 (48%) | 0% | 4.2 | 2,320,397 | Common Stock |
| Jeffrey B. Kindler | Director | Sale of securities on an exchange or to another person at price $ 3.63 per share. | 12 Dec 2025 | 235,467 | 110,603 (0%) | 0% | 3.6 | 855,899 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 4.47 per share. | 19 Nov 2025 | 1,086,153 | 7,434,384 (4%) | 0% | 4.5 | 4,855,104 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 3.83 per share. | 19 Nov 2025 | 937,308 | 5,554,244 (3%) | 0% | 3.8 | 3,589,890 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 4.08 per share. | 19 Nov 2025 | 942,832 | 6,491,552 (3%) | 0% | 4.1 | 3,846,755 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 3.41 per share. | 30 Sep 2025 | 1,809,667 | 14,597,161 (8%) | 1% | 3.4 | 6,170,964 | Common Stock |
| Phil Tennant | Chief Commercial Officer | Purchase of securities on an exchange or from another person at price $ 3.58 per share. | 29 Sep 2025 | 6,000 | 65,031 (0%) | 0% | 3.6 | 21,480 | Common Stock |
| Jeffrey B. Kindler | Director | Sale of securities on an exchange or to another person at price $ 3.38 per share. | 29 Sep 2025 | 106,837 | 346,070 (0%) | 0% | 3.4 | 361,109 | Common Stock |
| Jeffrey B. Kindler | Director | Sale of securities on an exchange or to another person at price $ 3.60 per share. | 29 Sep 2025 | 67,523 | 452,907 (0%) | 0% | 3.6 | 243,083 | Common Stock |
| Rutul R. Shah | Chief Operating Officer | Purchase of securities on an exchange or from another person at price $ 3.40 per share. | 26 Sep 2025 | 2,000 | 405,959 (0%) | 0% | 3.4 | 6,800 | Common Stock |
| Harry Thomasian | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 3.42 per share. | 25 Sep 2025 | 2,932 | 468,626 (0%) | 0% | 3.4 | 10,027 | Common Stock |
| Harry Thomasian | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 3.62 per share. | 25 Sep 2025 | 8,284 | 465,694 (0%) | 0% | 3.6 | 29,988 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Sep 2025 | 25,000 | 0 | - | - | 8.00% Series A Convertible Perpetual Preferred Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 3.68 per share. | 17 Sep 2025 | 3,596,892 | 8,520,537 (5%) | 2% | 3.7 | 13,236,563 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 3.86 per share. | 17 Sep 2025 | 1,403,360 | 12,117,429 (7%) | 0% | 3.9 | 5,416,970 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Sep 2025 | 17,385,257 | 82,164,767 (48%) | 10% | - | Common Stock | |
| Donald P. Lehr | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Sep 2025 | 54,000 | 54,000 | - | - | Performance Stock Units | |
| Helen Sabzevari | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Sep 2025 | 825,000 | 825,000 | - | - | Performance Stock Units | |
| Harry Thomasian | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Sep 2025 | 125,000 | 125,000 | - | - | Performance Stock Units | |
| Rutul R. Shah | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Sep 2025 | 125,000 | 125,000 | - | - | Performance Stock Units | |
| Phil Tennant | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Sep 2025 | 25,000 | 25,000 | - | - | Performance Stock Units | |
| Nancy Howell Agee | Director | Purchase of securities on an exchange or from another person at price $ 4.60 per share. | 04 Sep 2025 | 15,000 | 217,841 (0%) | 0% | 4.6 | 69,000 | Common Stock |
| Nancy Howell Agee | Director | Purchase of securities on an exchange or from another person at price $ 3.20 per share. | 19 Aug 2025 | 15,360 | 192,196 (0%) | 0% | 3.2 | 49,152 | Common Stock |
| Nancy Howell Agee | Director | Purchase of securities on an exchange or from another person at price $ 4.65 per share. | 19 Aug 2025 | 10,645 | 202,841 (0%) | 0% | 4.6 | 49,491 | Common Stock |
| Nancy Howell Agee | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jul 2025 | 126,760 | 176,836 (0%) | 0% | - | Common Stock | |
| Nancy Howell Agee | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jul 2025 | 126,760 | 0 | - | - | Restricted Stock Units | |
| Donald P. Lehr | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2025 | 125,000 | 125,000 | - | - | Restricted Stock Units | |
| Helen Sabzevari | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2025 | 500,000 | 500,000 | - | - | Restricted Stock Units | |
| Harry Thomasian | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2025 | 175,000 | 175,000 | - | - | Restricted Stock Units | |
| Rutul R. Shah | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2025 | 180,000 | 180,000 | - | - | Restricted Stock Units | |
| Phil Tennant | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2025 | 125,000 | 125,000 | - | - | Restricted Stock Units | |
| Donald P. Lehr | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2025 | 250,000 | 250,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Helen Sabzevari | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2025 | 1,000,000 | 1,000,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Harry Thomasian | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2025 | 350,000 | 350,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Rutul R. Shah | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2025 | 360,000 | 360,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Phil Tennant | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2025 | 250,000 | 250,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Donald P. Lehr | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2025 | 165,468 | 0 | - | - | Restricted Stock Units | |
| Donald P. Lehr | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2025 | 165,468 | 736,750 (0%) | 0% | - | Common Stock | |
| Donald P. Lehr | Chief Legal Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.45 per share. | 16 May 2025 | 55,101 | 681,649 (0%) | 0% | 1.4 | 79,896 | Common Stock |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2025 | 1,079,137 | 3,838,246 (2%) | 0% | - | Common Stock | |
| Helen Sabzevari | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.45 per share. | 16 May 2025 | 521,224 | 3,317,022 (1%) | 0% | 1.5 | 755,775 | Common Stock |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2025 | 1,079,137 | 0 | - | - | Restricted Stock Units | |
| Harry Thomasian | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2025 | 154,475 | 508,851 (0%) | 0% | - | Common Stock | |
| Harry Thomasian | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2025 | 154,475 | 0 | - | - | Restricted Stock Units | |
| Harry Thomasian | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.45 per share. | 16 May 2025 | 51,441 | 457,410 (0%) | 0% | 1.4 | 74,589 | Common Stock |
| Rutul R. Shah | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2025 | 174,460 | 0 | - | - | Restricted Stock Units | |
| Rutul R. Shah | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2025 | 174,460 | 462,055 (0%) | 0% | - | Common Stock | |
| Rutul R. Shah | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.45 per share. | 16 May 2025 | 58,096 | 403,959 (0%) | 0% | 1.4 | 84,239 | Common Stock |
| Phil Tennant | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2025 | 66,441 | 0 | - | - | Restricted Stock Units | |
| Phil Tennant | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2025 | 66,441 | 82,000 (0%) | 0% | - | Common Stock | |
| Phil Tennant | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.45 per share. | 16 May 2025 | 22,969 | 59,031 (0%) | 0% | 1.4 | 33,305 | Common Stock |
| Donald P. Lehr | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Apr 2025 | 165,468 | 165,468 | - | - | Restricted Stock Units | |
| Helen Sabzevari | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Apr 2025 | 1,079,137 | 1,079,137 | - | - | Restricted Stock Units | |
| Harry Thomasian | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Apr 2025 | 154,475 | 154,475 | - | - | Restricted Stock Units | |
| Rutul R. Shah | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Apr 2025 | 174,460 | 174,460 | - | - | Restricted Stock Units | |
| Phil Tennant | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Apr 2025 | 66,441 | 66,441 | - | - | Restricted Stock Units | |
| Fred Hassan | Director | Grant, award, or other acquisition of securities at price $ 1.74 per share. | 13 Mar 2025 | 36,206 | 1,066,040 (0%) | 0% | 1.7 | 62,998 | Common Stock |
| Fred Hassan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Mar 2025 | 83,517 | 83,517 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Fred Hassan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2025 | 87,412 | 0 | - | - | Restricted Stock Units | |
| Fred Hassan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Mar 2025 | 71,839 | 71,839 | - | - | Restricted Stock Units | |
| Fred Hassan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2025 | 87,412 | 1,153,452 (0%) | 0% | - | Common Stock | |
| Jeffrey B. Kindler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Mar 2025 | 83,517 | 83,517 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Jeffrey B. Kindler | Director | Grant, award, or other acquisition of securities at price $ 1.74 per share. | 13 Mar 2025 | 39,655 | 433,018 (0%) | 0% | 1.7 | 69,000 | Common Stock |
| Jeffrey B. Kindler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2025 | 87,412 | 520,430 (0%) | 0% | - | Common Stock | |
| Jeffrey B. Kindler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Mar 2025 | 71,839 | 71,839 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2025 | 87,412 | 0 | - | - | Restricted Stock Units | |
| Nancy Howell Agee | Director | Grant, award, or other acquisition of securities at price $ 1.74 per share. | 13 Mar 2025 | 32,471 | 50,076 (0%) | 0% | 1.7 | 56,500 | Common Stock |
| Nancy Howell Agee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Mar 2025 | 83,517 | 83,517 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Nancy Howell Agee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Mar 2025 | 71,839 | 71,839 | - | - | Restricted Stock Units | |
| Randal J. Kirk | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 1.74 per share. | 13 Mar 2025 | 57,471 | 64,604,685 (38%) | 0% | 1.7 | 100,000 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2025 | 174,825 | 0 | - | - | Restricted Stock Units | |
| Randal J. Kirk | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Mar 2025 | 167,034 | 167,034 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Randal J. Kirk | Director, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2025 | 174,825 | 64,779,510 (38%) | 0% | 0 | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Mar 2025 | 143,678 | 143,678 | - | - | Restricted Stock Units | |
| Cesar L. Alvarez | Director | Grant, award, or other acquisition of securities at price $ 1.74 per share. | 13 Mar 2025 | 35,919 | 605,852 (0%) | 0% | 1.7 | 62,499 | Common Stock |
| Cesar L. Alvarez | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Mar 2025 | 71,839 | 71,839 | - | - | Restricted Stock Units | |
| Cesar L. Alvarez | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2025 | 87,412 | 0 | - | - | Restricted Stock Units | |
| Cesar L. Alvarez | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Mar 2025 | 83,517 | 83,517 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Cesar L. Alvarez | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2025 | 87,412 | 693,264 (0%) | 0% | - | Common Stock | |
| James S. Turley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Mar 2025 | 71,839 | 71,839 | - | - | Restricted Stock Units | |
| James S. Turley | Director | Grant, award, or other acquisition of securities at price $ 1.74 per share. | 13 Mar 2025 | 35,919 | 508,360 (0%) | 0% | 1.7 | 62,499 | Common Stock |
| James S. Turley | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2025 | 87,412 | 595,772 (0%) | 0% | - | Common Stock | |
| James S. Turley | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2025 | 87,412 | 0 | - | - | Restricted Stock Units | |
| James S. Turley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Mar 2025 | 83,517 | 83,517 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Steven Frank | Director | Grant, award, or other acquisition of securities at price $ 1.74 per share. | 13 Mar 2025 | 28,735 | 1,052,895 (0%) | 0% | 1.7 | 49,999 | Common Stock |
| Steven Frank | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Mar 2025 | 83,517 | 83,517 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Steven Frank | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2025 | 87,412 | 0 | - | - | Restricted Stock Units | |
| Steven Frank | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Mar 2025 | 71,839 | 71,839 | - | - | Restricted Stock Units | |
| Steven Frank | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2025 | 87,412 | 1,140,307 (0%) | 0% | - | Common Stock | |
| Vinita D. Gupta | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2025 | 87,412 | 576,240 (0%) | 0% | - | Common Stock | |
| Vinita D. Gupta | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Mar 2025 | 83,517 | 83,517 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Vinita D. Gupta | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2025 | 87,412 | 0 | - | - | Restricted Stock Units | |
| Vinita D. Gupta | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Mar 2025 | 71,839 | 71,839 | - | - | Restricted Stock Units | |
| Vinita D. Gupta | Director | Grant, award, or other acquisition of securities at price $ 1.74 per share. | 13 Mar 2025 | 36,206 | 488,828 (0%) | 0% | 1.7 | 62,998 | Common Stock |
| Donald P. Lehr | Chief Legal Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.30 per share. | 29 Jan 2025 | 20,844 | 571,282 (0%) | 0% | 1.3 | 27,097 | Common Stock |
| Donald P. Lehr | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2025 | 54,000 | 592,126 (0%) | 0% | 0 | Common Stock | |
| Helen Sabzevari | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2025 | 825,000 | 3,046,076 (1%) | 0% | 0 | Common Stock | |
| Helen Sabzevari | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.30 per share. | 29 Jan 2025 | 286,967 | 2,759,109 (1%) | 0% | 1.3 | 373,057 | Common Stock |
| Harry Thomasian | Chief Financial Office | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2025 | 125,000 | 354,376 (0%) | 0% | 0 | Common Stock | |
| Rutul R. Shah | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2025 | 125,000 | 334,746 (0%) | 0% | 0 | Common Stock | |
| Rutul R. Shah | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.30 per share. | 29 Jan 2025 | 47,151 | 287,595 (0%) | 0% | 1.3 | 61,296 | Common Stock |
| Phil Tennant | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2025 | 25,000 | 25,000 (0%) | 0% | 0 | Common Stock | |
| Phil Tennant | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.30 per share. | 29 Jan 2025 | 9,441 | 15,559 (0%) | 0% | 1.3 | 12,273 | Common Stock |
| J. Randal Kirk | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 30 Dec 2024 | 25,000 | 25,000 | - | - | 8.00% Series A Convertible Perpetual Preferred Stock | |
| Kirk Randal J. | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 30 Dec 2024 | 16,666,667 | 16,666,667 | - | - | Warrant to Purchase Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.85 per share. | 09 Aug 2024 | 23,529,411 | 64,547,214 (38%) | 13% | 0.8 | 19,999,999 | Common Stock |
| Jeffrey Thomas Perez | SVP, IP Affairs | Purchase of securities on an exchange or from another person at price $ 0.85 per share. | 09 Aug 2024 | 58,823 | 743,097 (0%) | 0% | 0.9 | 50,000 | Common Stock |
| Phil Tennant | Chief Commercial Officer | 22 Jul 2024 | 200,000 | 200,000 | - | - | Option to Purchase Common Stock (Right to Buy) | ||
| Nancy Howell Agee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jul 2024 | 147,540 | 147,540 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Nancy Howell Agee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jul 2024 | 126,760 | 126,760 | - | - | Restricted Stock Units | |
| Nancy Howell Agee | Director | Grant, award, or other acquisition of securities at price $ 1.42 per share. | 05 Jul 2024 | 17,605 | 17,605 (0%) | 0% | 1.4 | 24,999 | Common Stock |
| Donald P. Lehr | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 400,000 | 400,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 300,000 | 300,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Helen Sabzevari | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 1,803,000 | 1,803,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Harry Thomasian | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 500,000 | 500,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Rutul R. Shah | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 550,000 | 550,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 02 May 2024 | 59,133 | 0 (0%) | 0% | 0 | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 02 May 2024 | 118,266 | 0 (0%) | 0% | 0 | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 02 May 2024 | 8,790,674 | 0 (0%) | 5% | 0 | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 02 May 2024 | 58,800 | 0 (0%) | 0% | 0 | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 02 May 2024 | 6,085,471 | 6,085,471 (3%) | 3% | 0 | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 02 May 2024 | 8,896,412 | 41,017,803 (24%) | 5% | 0 | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 02 May 2024 | 691,929 | 0 (0%) | 0% | 0 | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 02 May 2024 | 1,383,858 | 0 (0%) | 0% | 0 | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 02 May 2024 | 832,500 | 0 (0%) | 0% | 0 | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 02 May 2024 | 2,497,500 | 0 (0%) | 1% | 0 | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 02 May 2024 | 4,995,000 | 0 (0%) | 2% | 0 | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 02 May 2024 | 19,711 | 0 (0%) | 0% | 0 | Common Stock | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Other type of transaction at price $ 0.00 per share. | 02 May 2024 | 126,713 | 684,274 (0%) | 0% | 0 | Common Stock | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2024 | 142,857 | 142,857 | - | - | Restricted Stock Units | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.40 per share. | 05 Apr 2024 | 44,199 | 557,561 (0%) | 0% | 1.4 | 61,879 | Common Stock |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Apr 2024 | 1,071,429 | 0 | - | - | Restricted Stock Units | |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Apr 2024 | 1,071,429 | 2,631,433 (1%) | 0% | - | Common Stock | |
| Helen Sabzevari | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.40 per share. | 05 Apr 2024 | 410,357 | 2,221,076 (1%) | 0% | 1.4 | 574,500 | Common Stock |
| Helen Sabzevari | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2024 | 1,071,429 | 1,071,429 | - | - | Restricted Stock Units | |
| Harry Thomasian | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.40 per share. | 05 Apr 2024 | 67,389 | 229,376 (0%) | 0% | 1.4 | 94,345 | Common Stock |
| Harry Thomasian | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Apr 2024 | 135,714 | 0 | - | - | Restricted Stock Units | |
| Harry Thomasian | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2024 | 135,714 | 135,714 | - | - | Restricted Stock Units | |
| Harry Thomasian | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Apr 2024 | 135,714 | 296,765 (0%) | 0% | - | Common Stock | |
| Rutul R. Shah | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Apr 2024 | 117,142 | 0 | - | - | Restricted Stock Units | |
| Rutul R. Shah | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Apr 2024 | 117,142 | 250,616 (0%) | 0% | - | Common Stock | |
| Rutul R. Shah | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.40 per share. | 05 Apr 2024 | 40,870 | 209,746 (0%) | 0% | 1.4 | 57,218 | Common Stock |
| Rutul R. Shah | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2024 | 117,142 | 117,142 | - | - | Restricted Stock Units | |
| Donald P. Lehr | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Apr 2024 | 164,285 | 593,201 (0%) | 0% | - | Common Stock | |
| Donald P. Lehr | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Apr 2024 | 164,285 | 0 | - | - | Restricted Stock Units | |
| Donald P. Lehr | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2024 | 164,285 | 164,285 | - | - | Restricted Stock Units | |
| Donald P. Lehr | Chief Legal Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.40 per share. | 05 Apr 2024 | 55,075 | 538,126 (0%) | 0% | 1.4 | 77,105 | Common Stock |
| Jeffrey Thomas Perez | SVP, IP Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Apr 2024 | 142,857 | 601,760 (0%) | 0% | - | Common Stock | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Apr 2024 | 142,857 | 0 | - | - | Restricted Stock Units | |
| Dean Jonathan Mitchell | Director | Grant, award, or other acquisition of securities at price $ 1.43 per share. | 14 Mar 2024 | 39,510 | 503,183 (0%) | 0% | 1.4 | 56,499 | Common Stock |
| Dean Jonathan Mitchell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 87,412 | 87,412 | - | - | Restricted Stock Units | |
| Dean Jonathan Mitchell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 101,626 | 101,626 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Fred Hassan | Director | Grant, award, or other acquisition of securities at price $ 1.43 per share. | 14 Mar 2024 | 44,055 | 1,029,834 (0%) | 0% | 1.4 | 62,999 | Common Stock |
| Fred Hassan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 101,626 | 101,626 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Fred Hassan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 87,412 | 87,412 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 101,626 | 101,626 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Jeffrey B. Kindler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 87,412 | 87,412 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Grant, award, or other acquisition of securities at price $ 1.43 per share. | 14 Mar 2024 | 48,251 | 393,363 (0%) | 0% | 1.4 | 68,999 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 1.43 per share. | 14 Mar 2024 | 69,930 | 32,121,391 (18%) | 0% | 1.4 | 100,000 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 203,252 | 203,252 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Randal J. Kirk | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 174,825 | 174,825 | - | - | Restricted Stock Units | |
| Cesar L. Alvarez | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 87,412 | 87,412 | - | - | Restricted Stock Units | |
| Cesar L. Alvarez | Director | Grant, award, or other acquisition of securities at price $ 1.43 per share. | 14 Mar 2024 | 43,706 | 569,933 (0%) | 0% | 1.4 | 62,500 | Common Stock |
| Cesar L. Alvarez | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 101,626 | 101,626 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| James S. Turley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 87,412 | 87,412 | - | - | Restricted Stock Units | |
| James S. Turley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 101,626 | 101,626 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| James S. Turley | Director | Grant, award, or other acquisition of securities at price $ 1.43 per share. | 14 Mar 2024 | 43,706 | 472,441 (0%) | 0% | 1.4 | 62,500 | Common Stock |
| Steven Frank | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 101,626 | 101,626 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Steven Frank | Director | Grant, award, or other acquisition of securities at price $ 1.43 per share. | 14 Mar 2024 | 34,965 | 1,024,160 (0%) | 0% | 1.4 | 50,000 | Common Stock |
| Steven Frank | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 87,412 | 87,412 | - | - | Restricted Stock Units | |
| Vinita D. Gupta | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 87,412 | 87,412 | - | - | Restricted Stock Units | |
| Vinita D. Gupta | Director | Grant, award, or other acquisition of securities at price $ 1.43 per share. | 14 Mar 2024 | 44,055 | 452,622 (0%) | 0% | 1.4 | 62,999 | Common Stock |
| Vinita D. Gupta | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 101,626 | 101,626 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Dean Jonathan Mitchell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2024 | 106,837 | 0 | - | - | Restricted Stock Units | |
| Dean Jonathan Mitchell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2024 | 106,837 | 463,673 (0%) | 0% | - | Common Stock | |
| Fred Hassan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2024 | 106,837 | 0 | - | - | Restricted Stock Units | |
| Fred Hassan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2024 | 106,837 | 985,779 (0%) | 0% | - | Common Stock | |
| Jeffrey B. Kindler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2024 | 106,837 | 345,112 (0%) | 0% | - | Common Stock | |
| Jeffrey B. Kindler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2024 | 106,837 | 0 | - | - | Restricted Stock Units | |
| Randal J. Kirk | Director, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2024 | 213,675 | 32,051,461 (18%) | 0% | 0 | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2024 | 213,675 | 0 | - | - | Restricted Stock Units | |
| Cesar L. Alvarez | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2024 | 106,837 | 526,227 (0%) | 0% | - | Common Stock | |
| Cesar L. Alvarez | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2024 | 106,837 | 0 | - | - | Restricted Stock Units | |
| James S. Turley | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2024 | 106,837 | 0 | - | - | Restricted Stock Units | |
| James S. Turley | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2024 | 106,837 | 428,735 (0%) | 0% | - | Common Stock | |
| Steven Frank | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2024 | 106,837 | 0 | - | - | Restricted Stock Units | |
| Steven Frank | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2024 | 106,837 | 989,195 (0%) | 0% | - | Common Stock | |
| Vinita D. Gupta | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2024 | 106,837 | 0 | - | - | Restricted Stock Units | |
| Vinita D. Gupta | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2024 | 106,837 | 408,567 (0%) | 0% | - | Common Stock | |
| Kirk J. Randal | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 1.41 per share. | 28 Dec 2023 | 96,686 | 1,096,686 (0%) | 0% | 1.4 | 136,327 | Common Stock |
| Jeffrey Kindler B. | Director | Sale of securities on an exchange or to another person at price $ 1.41 per share. | 28 Dec 2023 | 96,686 | 238,275 (0%) | 0% | 1.4 | 136,327 | Common Stock |
| Donald P. Lehr | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2023 | 21,710 | 0 | - | - | Restricted Stock Units | |
| Donald P. Lehr | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2023 | 21,710 | 439,863 (0%) | 0% | - | Common Stock | |
| Donald P. Lehr | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 1.64 per share. | 23 Aug 2023 | 10,947 | 428,916 (0%) | 0% | 1.6 | 17,953 | Common Stock |
| Jeffrey Thomas Perez | SVP, IP Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2023 | 18,878 | 0 | - | - | Restricted Stock Unit | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2023 | 18,878 | 467,794 (0%) | 0% | - | Common Stock | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Sale of securities on an exchange or to another person at price $ 1.64 per share. | 23 Aug 2023 | 8,891 | 458,903 (0%) | 0% | 1.6 | 14,581 | Common Stock |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2023 | 141,587 | 0 | - | - | Restricted Stock Units | |
| Helen Sabzevari | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 1.53 per share. | 23 Aug 2023 | 76,969 | 1,560,004 (0%) | 0% | 1.5 | 117,763 | Common Stock |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2023 | 141,587 | 1,636,973 (0%) | 0% | - | Common Stock | |
| Harry Thomasian | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2023 | 17,934 | 0 | - | - | Restricted Stock Units | |
| Harry Thomasian | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2023 | 17,934 | 170,096 (0%) | 0% | - | Common Stock | |
| Harry Thomasian | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 1.64 per share. | 23 Aug 2023 | 9,045 | 161,051 (0%) | 0% | 1.6 | 14,834 | Common Stock |
| Rutul R. Shah | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 1.64 per share. | 23 Aug 2023 | 5,388 | 133,474 (0%) | 0% | 1.6 | 8,836 | Common Stock |
| Rutul R. Shah | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2023 | 15,480 | 138,862 (0%) | 0% | - | Common Stock | |
| Rutul R. Shah | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2023 | 15,480 | 0 | - | - | Restricted Stock Units | |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Aug 2023 | 141,587 | 141,587 | - | - | Restricted Stock Units | |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Aug 2023 | 141,587 | 1,551,241 (0%) | 0% | - | Common Stock | |
| Helen Sabzevari | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 1.66 per share. | 16 Aug 2023 | 55,855 | 1,495,386 (0%) | 0% | 1.7 | 92,719 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 1.51 per share. | 15 Aug 2023 | 119,411 | 31,837,786 (18%) | 0% | 1.5 | 180,311 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 1.52 per share. | 15 Aug 2023 | 200,000 | 31,718,375 (18%) | 0% | 1.5 | 304,000 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 1.53 per share. | 15 Aug 2023 | 80,589 | 31,518,375 (18%) | 0% | 1.5 | 123,301 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 1.50 per share. | 15 Aug 2023 | 100,000 | 31,437,786 (18%) | 0% | 1.5 | 150,000 | Common Stock |
| Fred Hassan | Director | Purchase of securities on an exchange or from another person at price $ 1.75 per share. | 14 Aug 2023 | 570,345 | 878,942 (0%) | 0% | 1.8 | 998,104 | Common Stock |
| Steven Frank | Director | Purchase of securities on an exchange or from another person at price $ 1.72 per share. | 14 Aug 2023 | 400,000 | 882,358 (0%) | 0% | 1.7 | 688,000 | Common Stock |
| Donald P. Lehr | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Aug 2023 | 21,710 | 65,130 | - | - | Restricted Stock Units | |
| Donald P. Lehr | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Aug 2023 | 21,710 | 407,342 (0%) | 0% | - | Common Stock | |
| Donald P. Lehr | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 1.20 per share. | 02 Aug 2023 | 10,821 | 396,521 (0%) | 0% | 1.2 | 12,985 | Common Stock |
| Jeffrey Thomas Perez | SVP, IP Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Aug 2023 | 18,878 | 437,646 (0%) | 0% | - | Common Stock | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Aug 2023 | 18,878 | 56,634 | - | - | Restricted Stock Unit | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Sale of securities on an exchange or to another person at price $ 1.20 per share. | 02 Aug 2023 | 8,789 | 428,857 (0%) | 0% | 1.2 | 10,547 | Common Stock |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Aug 2023 | 141,587 | 1,362,373 (0%) | 0% | - | Common Stock | |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Aug 2023 | 141,587 | 424,760 | - | - | Restricted Stock Units | |
| Helen Sabzevari | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 1.10 per share. | 02 Aug 2023 | 52,870 | 1,309,503 (0%) | 0% | 1.1 | 58,157 | Common Stock |
| Harry Thomasian | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Aug 2023 | 17,934 | 53,802 | - | - | Restricted Stock Units | |
| Harry Thomasian | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 1.20 per share. | 02 Aug 2023 | 6,724 | 132,039 (0%) | 0% | 1.2 | 8,069 | Common Stock |
| Harry Thomasian | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Aug 2023 | 17,934 | 138,763 (0%) | 0% | - | Common Stock | |
| Rutul R. Shah | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Aug 2023 | 15,480 | 108,477 (0%) | 0% | - | Common Stock | |
| Rutul R. Shah | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Aug 2023 | 15,480 | 46,440 | - | - | Restricted Stock Units | |
| Rutul R. Shah | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 1.20 per share. | 02 Aug 2023 | 5,328 | 103,149 (0%) | 0% | 1.2 | 6,394 | Common Stock |
| Donald P. Lehr | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2023 | 300,000 | 300,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2023 | 200,000 | 200,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Helen Sabzevari | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2023 | 1,732,300 | 1,732,300 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Harry Thomasian | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2023 | 521,000 | 521,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Rutul R. Shah | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2023 | 500,000 | 500,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Donald P. Lehr | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Mar 2023 | 43,419 | 86,839 | - | - | Restricted Stock Units | |
| Donald P. Lehr | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Mar 2023 | 43,419 | 385,632 (0%) | 0% | - | Common Stock | |
| Donald P. Lehr | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Mar 2023 | 130,258 | 130,258 | - | - | Restricted Stock Units | |
| Donald P. Lehr | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Mar 2023 | 56,671 | 56,671 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Mar 2023 | 37,756 | 75,512 | - | - | Restricted Stock Units | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Mar 2023 | 37,756 | 418,768 (0%) | 0% | - | Common Stock | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Mar 2023 | 113,268 | 113,268 | - | - | Restricted Stock Units | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Mar 2023 | 49,279 | 49,279 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Helen Sabzevari | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Mar 2023 | 369,596 | 369,596 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Helen Sabzevari | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Mar 2023 | 849,520 | 849,520 | - | - | Restricted Stock Units | |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Mar 2023 | 283,173 | 566,347 | - | - | Restricted Stock Units | |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Mar 2023 | 283,173 | 1,220,786 (0%) | 0% | - | Common Stock | |
| Harry Thomasian | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Mar 2023 | 35,868 | 71,737 | - | - | Restricted Stock Units | |
| Harry Thomasian | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Mar 2023 | 35,868 | 120,829 (0%) | 0% | - | Common Stock | |
| Harry Thomasian | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Mar 2023 | 107,605 | 107,605 | - | - | Restricted Stock Units | |
| Harry Thomasian | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Mar 2023 | 46,815 | 46,815 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Rutul R. Shah | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Mar 2023 | 30,960 | 61,920 | - | - | Restricted Stock Units | |
| Rutul R. Shah | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Mar 2023 | 40,409 | 40,409 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Rutul R. Shah | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Mar 2023 | 92,880 | 92,880 | - | - | Restricted Stock Units | |
| Rutul R. Shah | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Mar 2023 | 30,960 | 92,997 (0%) | 0% | - | Common Stock | |
| Dean Jonathan Mitchell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 106,837 | 106,837 | - | - | Restricted Stock Units | |
| Dean Jonathan Mitchell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 125,489 | 125,489 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Dean Jonathan Mitchell | Director | Grant, award, or other acquisition of securities at price $ 1.17 per share. | 09 Mar 2023 | 48,290 | 331,836 (0%) | 0% | 1.2 | 56,499 | Common Stock |
| Fred Hassan | Director | Grant, award, or other acquisition of securities at price $ 1.17 per share. | 09 Mar 2023 | 48,290 | 308,597 (0%) | 0% | 1.2 | 56,499 | Common Stock |
| Fred Hassan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 125,489 | 125,489 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Fred Hassan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 106,837 | 106,837 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Grant, award, or other acquisition of securities at price $ 1.17 per share. | 09 Mar 2023 | 58,974 | 334,961 (0%) | 0% | 1.2 | 69,000 | Common Stock |
| Jeffrey B. Kindler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 106,837 | 106,837 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 125,489 | 125,489 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Randal J. Kirk | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 1.17 per share. | 09 Mar 2023 | 85,470 | 31,337,786 (18%) | 0% | 1.2 | 100,000 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 250,978 | 250,978 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Randal J. Kirk | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 213,675 | 213,675 | - | - | Restricted Stock Units | |
| Cesar L. Alvarez | Director | Grant, award, or other acquisition of securities at price $ 1.17 per share. | 09 Mar 2023 | 53,418 | 419,390 (0%) | 0% | 1.2 | 62,499 | Common Stock |
| Cesar L. Alvarez | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 125,489 | 125,489 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Cesar L. Alvarez | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 106,837 | 106,837 | - | - | Restricted Stock Units | |
| Robert B. Shapiro | Director | Grant, award, or other acquisition of securities at price $ 1.17 per share. | 09 Mar 2023 | 26,923 | 329,656 (0%) | 0% | 1.2 | 31,500 | Common Stock |
| Robert B. Shapiro | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 130,398 | 130,398 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Robert B. Shapiro | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 53,418 | 53,418 | - | - | Restricted Stock Units | |
| James S. Turley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 106,837 | 106,837 | - | - | Restricted Stock Units | |
| James S. Turley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 125,489 | 125,489 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| James S. Turley | Director | Grant, award, or other acquisition of securities at price $ 1.17 per share. | 09 Mar 2023 | 53,418 | 321,898 (0%) | 0% | 1.2 | 62,499 | Common Stock |
| Steven Frank | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 125,489 | 125,489 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Steven Frank | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 106,837 | 106,837 | - | - | Restricted Stock Units | |
| Steven Frank | Director | Grant, award, or other acquisition of securities at price $ 1.17 per share. | 09 Mar 2023 | 42,735 | 482,358 (0%) | 0% | 1.2 | 50,000 | Common Stock |
| Vinita D. Gupta | Director | Grant, award, or other acquisition of securities at price $ 1.17 per share. | 09 Mar 2023 | 48,290 | 301,730 (0%) | 0% | 1.2 | 56,499 | Common Stock |
| Vinita D. Gupta | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 125,489 | 125,489 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Vinita D. Gupta | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 106,837 | 106,837 | - | - | Restricted Stock Units | |
| Dean Jonathan Mitchell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2023 | 61,576 | 0 | - | - | Restricted Stock Units | |
| Dean Jonathan Mitchell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2023 | 61,576 | 283,546 (0%) | 0% | - | Common Stock | |
| Fred Hassan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2023 | 61,576 | 260,307 (0%) | 0% | - | Common Stock | |
| Fred Hassan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2023 | 61,576 | 0 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2023 | 61,576 | 0 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2023 | 61,576 | 275,987 (0%) | 0% | - | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2023 | 123,152 | 0 | - | - | Restricted Stock Units | |
| Randal J. Kirk | Director, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2023 | 123,152 | 31,252,316 (18%) | 0% | 0 | Common Stock | |
| Cesar L. Alvarez | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2023 | 61,576 | 365,972 (0%) | 0% | - | Common Stock | |
| Cesar L. Alvarez | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2023 | 61,576 | 0 | - | - | Restricted Stock Units | |
| Robert B. Shapiro | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2023 | 61,576 | 0 | - | - | Restricted Stock Units | |
| Robert B. Shapiro | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2023 | 61,576 | 302,733 (0%) | 0% | - | Common Stock | |
| James S. Turley | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2023 | 61,576 | 0 | - | - | Restricted Stock Units | |
| James S. Turley | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2023 | 61,576 | 268,480 (0%) | 0% | - | Common Stock | |
| Steven Frank | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2023 | 61,576 | 0 | - | - | Restricted Stock Units | |
| Steven Frank | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2023 | 61,576 | 439,623 (0%) | 0% | - | Common Stock | |
| Vinita D. Gupta | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2023 | 61,576 | 253,440 (0%) | 0% | - | Common Stock | |
| Vinita D. Gupta | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2023 | 61,576 | 0 | - | - | Restricted Stock Units | |
| Randal J. Kirk | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 1.75 per share. | 27 Jan 2023 | 11,428,571 | 31,129,164 (18%) | 6% | 1.7 | 19,999,999 | Common Stock |
| Jeffrey Thomas Perez | SVP, IP Affairs | Purchase of securities on an exchange or from another person at price $ 1.75 per share. | 27 Jan 2023 | 28,571 | 381,012 (0%) | 0% | 1.7 | 49,999 | Common Stock |
| Helen Sabzevari | President and CEO | Purchase of securities on an exchange or from another person at price $ 1.75 per share. | 27 Jan 2023 | 22,857 | 937,613 (0%) | 0% | 1.8 | 40,000 | Common Stock |
| Harry Thomasian | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 1.75 per share. | 27 Jan 2023 | 28,571 | 84,961 (0%) | 0% | 1.7 | 49,999 | Common Stock |
| Rutul R. Shah | Chief Operating Officer | Purchase of securities on an exchange or from another person at price $ 1.75 per share. | 27 Jan 2023 | 9,142 | 62,037 (0%) | 0% | 1.8 | 15,999 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2023 | 3,443 | 0 | - | - | Restricted Stock Units | |
| Randal J. Kirk | Director, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2023 | 3,443 | 19,700,593 (11%) | 0% | - | Common Stock | |
| Donald P. Lehr | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2023 | 18,939 | 0 | - | - | Restricted Stock Units | |
| Donald P. Lehr | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2023 | 18,939 | 342,213 (0%) | 0% | - | Common Stock | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2023 | 18,939 | 0 | - | - | Restricted Stock Units | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2023 | 18,939 | 352,441 (0%) | 0% | - | Common Stock | |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2023 | 17,665 | 0 | - | - | Restricted Stock Units | |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2023 | 17,665 | 914,756 (0%) | 0% | - | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 Oct 2022 | 26,361 | 1,015,604 (0%) | 0% | - | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 Oct 2022 | 6,326 | 453,731 (0%) | 0% | - | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 Oct 2022 | 8,435 | 351,120 (0%) | 0% | - | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 Oct 2022 | 10,544 | 578,079 (0%) | 0% | - | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 Oct 2022 | 42,177 | 1,637,040 (0%) | 0% | - | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 Oct 2022 | 105,445 | 3,944,437 (2%) | 0% | - | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 Oct 2022 | 10,544 | 489,438 (0%) | 0% | - | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 Oct 2022 | 42,177 | 1,654,363 (0%) | 0% | - | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 Oct 2022 | 105,445 | 3,703,398 (2%) | 0% | - | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 Oct 2022 | 10,544 | 490,401 (0%) | 0% | - | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 Oct 2022 | 660,091 | 19,697,150 (11%) | 0% | - | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 Oct 2022 | 26,374 | 1,015,626 (0%) | 0% | - | Common Stock | |
| Harry Thomasian | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 2.09 per share. | 23 Aug 2022 | 24,500 | 56,390 (0%) | 0% | 2.1 | 51,205 | Common Stock |
| Jeffrey B. Kindler | Director | Sale of securities on an exchange or to another person at price $ 2.30 per share. | 11 Aug 2022 | 50,000 | 214,411 (0%) | 0% | 2.3 | 115,000 | Common Stock |
| Donald P. Lehr | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 1.28 per share. | 16 May 2022 | 18,196 | 323,274 (0%) | 0% | 1.3 | 23,291 | Common Stock |
| Donald P. Lehr | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2022 | 36,590 | 0 | - | - | Restricted Stock Units | |
| Donald P. Lehr | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2022 | 36,590 | 341,470 (0%) | 0% | - | Common Stock | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2022 | 31,818 | 0 | - | - | Restricted Stock Units | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Sale of securities on an exchange or to another person at price $ 1.28 per share. | 16 May 2022 | 14,778 | 333,502 (0%) | 0% | 1.3 | 18,916 | Common Stock |
| Jeffrey Thomas Perez | SVP, IP Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2022 | 31,818 | 348,280 (0%) | 0% | - | Common Stock | |
| Harry Thomasian | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2022 | 8,109 | 34,609 (0%) | 0% | - | Common Stock | |
| Harry Thomasian | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2022 | 8,109 | 0 | - | - | Restricted Stock Units | |
| Harry Thomasian | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 1.28 per share. | 16 May 2022 | 2,719 | 31,890 (0%) | 0% | 1.3 | 3,480 | Common Stock |
| Helen Sabzevari | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 1.19 per share. | 12 May 2022 | 177,968 | 897,091 (0%) | 0% | 1.2 | 210,928 | Common Stock |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 May 2022 | 340,909 | 1,075,059 (0%) | 0% | - | Common Stock | |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 May 2022 | 340,909 | 0 | - | - | Restricted Stock Units | |
| Dean Jonathan Mitchell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Mar 2022 | 16,212 | 221,970 (0%) | 0% | - | Common Stock | |
| Dean Jonathan Mitchell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Mar 2022 | 16,212 | 0 | - | - | Restricted Stock Units | |
| Fred Hassan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Mar 2022 | 16,212 | 198,731 (0%) | 0% | - | Common Stock | |
| Fred Hassan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Mar 2022 | 16,212 | 0 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Mar 2022 | 16,212 | 264,411 (0%) | 0% | - | Common Stock | |
| Jeffrey B. Kindler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Mar 2022 | 16,212 | 0 | - | - | Restricted Stock Units | |
| Randal J. Kirk | Director, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Mar 2022 | 32,425 | 19,037,059 (11%) | 0% | 0 | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Mar 2022 | 32,425 | 0 | - | - | Restricted Stock Units | |
| Cesar L. Alvarez | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Mar 2022 | 16,212 | 0 | - | - | Restricted Stock Units | |
| Cesar L. Alvarez | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Mar 2022 | 16,212 | 304,396 (0%) | 0% | - | Common Stock | |
| Robert B. Shapiro | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Mar 2022 | 16,212 | 0 | - | - | Restricted Stock Units | |
| Robert B. Shapiro | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Mar 2022 | 16,212 | 241,157 (0%) | 0% | - | Common Stock | |
| James S. Turley | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Mar 2022 | 16,212 | 0 | - | - | Restricted Stock Units | |
| James S. Turley | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Mar 2022 | 16,212 | 206,904 (0%) | 0% | - | Common Stock | |
| Steven Frank | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Mar 2022 | 16,212 | 378,047 (0%) | 0% | - | Common Stock | |
| Steven Frank | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Mar 2022 | 16,212 | 0 | - | - | Restricted Stock Units | |
| Vinita D. Gupta | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Mar 2022 | 16,212 | 0 | - | - | Restricted Stock Units | |
| Vinita D. Gupta | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Mar 2022 | 16,212 | 191,864 (0%) | 0% | - | Common Stock | |
| Donald P. Lehr | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Mar 2022 | 36,590 | 36,590 | - | - | Restricted Stock Units | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Mar 2022 | 31,818 | 31,818 | - | - | Restricted Stock Units | |
| Helen Sabzevari | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Mar 2022 | 340,909 | 340,909 | - | - | Restricted Stock Units | |
| Harry Thomasian | Chief Financial Office | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Mar 2022 | 8,109 | 8,109 | - | - | Restricted Stock Units | |
| Dean Jonathan Mitchell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2022 | 61,576 | 61,576 | - | - | Restricted Stock Units | |
| Dean Jonathan Mitchell | Director | Grant, award, or other acquisition of securities at price $ 2.03 per share. | 22 Feb 2022 | 27,832 | 205,758 (0%) | 0% | 2.0 | 56,499 | Common Stock |
| Dean Jonathan Mitchell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2022 | 83,189 | 83,189 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Fred Hassan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2022 | 83,189 | 83,189 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Fred Hassan | Director | Grant, award, or other acquisition of securities at price $ 2.03 per share. | 22 Feb 2022 | 27,832 | 182,519 (0%) | 0% | 2.0 | 56,499 | Common Stock |
| Fred Hassan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2022 | 61,576 | 61,576 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Grant, award, or other acquisition of securities at price $ 2.03 per share. | 22 Feb 2022 | 33,990 | 248,199 (0%) | 0% | 2.0 | 69,000 | Common Stock |
| Jeffrey B. Kindler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2022 | 61,576 | 61,576 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2022 | 83,189 | 83,189 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Randal J. Kirk | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 2.03 per share. | 22 Feb 2022 | 49,261 | 19,004,634 (11%) | 0% | 2.0 | 100,000 | Common Stock |
| Randal J. Kirk | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2022 | 166,378 | 166,378 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Randal J. Kirk | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2022 | 123,152 | 123,152 | - | - | Restricted Stock Units | |
| Cesar L. Alvarez | Director | Grant, award, or other acquisition of securities at price $ 2.03 per share. | 22 Feb 2022 | 30,788 | 288,184 (0%) | 0% | 2.0 | 62,500 | Common Stock |
| Cesar L. Alvarez | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2022 | 83,189 | 83,189 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Cesar L. Alvarez | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2022 | 61,576 | 61,576 | - | - | Restricted Stock Units | |
| Robert B. Shapiro | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2022 | 83,189 | 83,189 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Robert B. Shapiro | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2022 | 61,576 | 61,576 | - | - | Restricted Stock Units | |
| Robert B. Shapiro | Director | Grant, award, or other acquisition of securities at price $ 2.03 per share. | 22 Feb 2022 | 31,034 | 224,945 (0%) | 0% | 2.0 | 62,999 | Common Stock |
| James S. Turley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2022 | 61,576 | 61,576 | - | - | Restricted Stock Units | |
| James S. Turley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2022 | 83,189 | 83,189 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| James S. Turley | Director | Grant, award, or other acquisition of securities at price $ 2.03 per share. | 22 Feb 2022 | 30,788 | 190,692 (0%) | 0% | 2.0 | 62,500 | Common Stock |
| Steven Frank | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2022 | 61,576 | 61,576 | - | - | Restricted Stock Units | |
| Steven Frank | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2022 | 83,189 | 83,189 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Steven Frank | Director | Grant, award, or other acquisition of securities at price $ 2.03 per share. | 22 Feb 2022 | 24,630 | 361,835 (0%) | 0% | 2.0 | 49,999 | Common Stock |
| Vinita D. Gupta | Director | Grant, award, or other acquisition of securities at price $ 2.03 per share. | 22 Feb 2022 | 27,832 | 175,652 (0%) | 0% | 2.0 | 56,499 | Common Stock |
| Vinita D. Gupta | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2022 | 83,189 | 83,189 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Vinita D. Gupta | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2022 | 61,576 | 61,576 | - | - | Restricted Stock Units | |
| Donald P. Lehr | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2022 | 150,000 | 150,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2022 | 150,000 | 150,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Helen Sabzevari | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2022 | 847,000 | 847,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Harry Thomasian | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2022 | 200,000 | 200,000 | - | - | Option to Purchase Common Stock (Right to Buy) | |
| Randal J. Kirk | Director, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2022 | 3,444 | 18,741,568 (11%) | 0% | - | Common Stock | |
| Randal J. Kirk | Director, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2022 | 3,444 | 3,444 | - | - | Restricted Stock Units | |
| Donald P. Lehr | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 3.59 per share. | 04 Jan 2022 | 10,356 | 304,880 (0%) | 0% | 3.6 | 37,180 | Common Stock |
| Donald P. Lehr | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2022 | 18,939 | 315,236 (0%) | 0% | - | Common Stock | |
| Donald P. Lehr | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2022 | 18,939 | 18,939 | - | - | Restricted Stock Units | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2022 | 18,939 | 18,939 | - | - | Restricted Stock Units | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Sale of securities on an exchange or to another person at price $ 3.59 per share. | 04 Jan 2022 | 9,738 | 316,462 (0%) | 0% | 3.6 | 34,960 | Common Stock |
| Jeffrey Thomas Perez | SVP, IP Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2022 | 18,939 | 326,200 (0%) | 0% | - | Common Stock | |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2022 | 17,667 | 741,110 (0%) | 0% | - | Common Stock | |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2022 | 17,667 | 17,665 | - | - | Restricted Stock Units | |
| Helen Sabzevari | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 3.59 per share. | 04 Jan 2022 | 5,603 | 734,150 (0%) | 0% | 3.6 | 20,115 | Common Stock |
| Helen Sabzevari | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 3.59 per share. | 04 Jan 2022 | 1,357 | 739,753 (0%) | 0% | 3.6 | 4,872 | Common Stock |
| Donald P. Lehr | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2022 | 9,765 | 0 | - | - | Restricted Stock Units | |
| Donald P. Lehr | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 3.67 per share. | 02 Jan 2022 | 5,315 | 296,297 (0%) | 0% | 3.7 | 19,507 | Common Stock |
| Donald P. Lehr | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2022 | 9,765 | 301,612 (0%) | 0% | - | Common Stock | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2022 | 9,765 | 312,283 (0%) | 0% | - | Common Stock | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2022 | 9,765 | 0 | - | - | Restricted Stock Units | |
| Jeffrey Thomas Perez | SVP, IP Affairs | Sale of securities on an exchange or to another person at price $ 3.67 per share. | 02 Jan 2022 | 5,022 | 307,261 (0%) | 0% | 3.7 | 18,431 | Common Stock |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2022 | 9,765 | 727,291 (0%) | 0% | - | Common Stock | |
| Helen Sabzevari | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2022 | 9,765 | 0 | - | - | Restricted Stock Units | |
| Helen Sabzevari | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 3.67 per share. | 02 Jan 2022 | 3,848 | 723,443 (0%) | 0% | 3.7 | 14,123 | Common Stock |
| Harry Thomasian | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 3.81 per share. | 26 Nov 2021 | 13,100 | 13,100 (0%) | 0% | 3.8 | 49,911 | Common Stock |