Joseph Loscalzo's most recent trade in Ionis Pharmaceuticals Inc was a trade of 5,369 Non-Qualified Stock Option (right to buy) done . Disclosure was reported to the exchange on July 1, 2026.
| Stock | Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|---|
| Ionis Pharma Inc | Joseph Loscalzo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2026 | 5,369 | 5,369 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2026 | 2,301 | 7,521 | - | - | Restricted Stock Unit | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Sale of securities on an exchange or to another person at price $ 74.90 per share. | 04 May 2026 | 59,508 | 54,111 (0%) | 0% | 74.9 | 4,457,292 | Common Stock |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Sale of securities on an exchange or to another person at price $ 75.58 per share. | 04 May 2026 | 17,781 | 36,330 (0%) | 0% | 75.6 | 1,343,934 | Common Stock |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 May 2026 | 16,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 May 2026 | 16,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 64.80 per share. | 04 May 2026 | 16,000 | 113,619 (0%) | 0% | 64.8 | 1,036,800 | Common Stock |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 42.88 per share. | 04 May 2026 | 16,000 | 85,619 (0%) | 0% | 42.9 | 686,080 | Common Stock |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 May 2026 | 12,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 May 2026 | 12,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 60.20 per share. | 04 May 2026 | 12,000 | 97,619 (0%) | 0% | 60.2 | 722,400 | Common Stock |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 40.05 per share. | 04 May 2026 | 12,000 | 59,298 (0%) | 0% | 40.1 | 480,600 | Common Stock |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.06 per share. | 04 May 2026 | 10,968 | 47,298 (0%) | 0% | 38.1 | 417,442 | Common Stock |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 May 2026 | 10,968 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 May 2026 | 10,321 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 41.08 per share. | 04 May 2026 | 10,321 | 69,619 (0%) | 0% | 41.1 | 423,987 | Common Stock |
| Leap Therapeutics Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2026 | 94,050 | 168,750 (0%) | 0% | - | Common Stock | |
| Leap Therapeutics Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2026 | 94,050 | 0 | - | - | Restricted Stock Units | |
| Leap Therapeutics Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2026 | 74,700 | 74,700 (0%) | 0% | - | Common Stock | |
| Leap Therapeutics Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2026 | 74,700 | 0 | - | - | Restricted Stock Units | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2026 | 832 | 11,168 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Sale of securities on an exchange or to another person at price $ 80.33 per share. | 03 Mar 2026 | 832 | 36,330 (0%) | 0% | 80.3 | 66,833 | Common Stock |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.06 per share. | 03 Mar 2026 | 832 | 37,162 (0%) | 0% | 38.1 | 31,666 | Common Stock |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2026 | 200 | 10,968 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Sale of securities on an exchange or to another person at price $ 80.00 per share. | 03 Mar 2026 | 200 | 36,330 (0%) | 0% | 80 | 16,000 | Common Stock |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.06 per share. | 03 Mar 2026 | 200 | 36,530 (0%) | 0% | 38.1 | 7,612 | Common Stock |
| Leap Therapeutics Inc | Joseph Loscalzo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Dec 2025 | 94,050 | 94,050 | - | - | Restricted Stock Units | |
| Leap Therapeutics Inc | Joseph Loscalzo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Nov 2025 | 74,700 | 74,700 | - | - | Restricted Stock Units | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.22 per share. | 31 Oct 2025 | 16,000 | 52,330 (0%) | 0% | 52.2 | 835,520 | Common Stock |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Oct 2025 | 16,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Sale of securities on an exchange or to another person at price $ 75.10 per share. | 31 Oct 2025 | 16,000 | 36,330 (0%) | 0% | 75.1 | 1,201,669 | Common Stock |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.42 per share. | 03 Sep 2025 | 16,000 | 52,330 (0%) | 0% | 24.4 | 390,720 | Common Stock |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 16,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Sale of securities on an exchange or to another person at price $ 60.15 per share. | 03 Sep 2025 | 16,000 | 36,330 (0%) | 0% | 60.1 | 962,371 | Common Stock |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 36,330 (0%) | 0% | 0 | Common Stock | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2025 | 4,079 | 5,220 | - | - | Restricted Stock Unit | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 11,518 | 11,518 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 5,220 | 9,299 | - | - | Restricted Stock Unit | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Sale of securities on an exchange or to another person at price $ 37.86 per share. | 12 Nov 2024 | 13,508 | 32,251 (0%) | 0% | 37.9 | 511,426 | Common Stock |
| Leap Therapeutics Inc | Joseph Loscalzo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Oct 2024 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 45,759 (0%) | 0% | 0 | Common Stock | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 4,079 | - | - | Restricted Stock Unit | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 10,111 | 10,111 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharma Inc | Joseph Loscalzo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 4,079 | 8,756 | - | - | Restricted Stock Unit | |
| Leap Therapeutics Inc | Joseph Loscalzo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2024 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Leap Therapeutics Inc | Joseph Loscalzo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Aug 2023 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Ionis Pharma Inc | Joseph Loscalzo | Director, Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 5,333 | 41,082 (0%) | 0% | 0 | Common Stock | |
| Ionis Pharma Inc | Joseph Loscalzo | Director, Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 5,333 | 4,677 | - | - | Restricted Stock Unit | |
| Ionis Pharma Inc | Joseph Loscalzo | Director, Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 1,777 | 10,010 | - | - | Restricted Stock Unit | |
| Ionis Pharma Inc | Joseph Loscalzo | Director, Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 1,777 | 35,749 (0%) | 0% | 0 | Common Stock | |
| Ionis Pharma Inc | Joseph Loscalzo | Director, Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jul 2023 | 10,321 | 10,321 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharma Inc | Joseph Loscalzo | Director, Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jul 2023 | 4,677 | 11,787 | - | - | Restricted Stock Unit | |
| Leap Therapeutics Inc | Joseph Loscalzo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2023 | 150,000 | 150,000 | - | - | Stock Option (Right to Buy) | |
| Ionis Pharma Inc | Joseph Loscalzo | Director, Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2022 | 5,333 | 9,775 | - | - | Restricted Stock Unit | |
| Ionis Pharma Inc | Joseph Loscalzo | Director, Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2022 | 5,333 | 31,307 (0%) | 0% | 0 | Common Stock | |
| Ionis Pharma Inc | Joseph Loscalzo | Director, Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2022 | 2,665 | 7,110 | - | - | Restricted Stock Unit | |
| Ionis Pharma Inc | Joseph Loscalzo | Director, Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2022 | 2,665 | 33,972 (0%) | 0% | 0 | Common Stock | |
| Ionis Pharma Inc | Joseph Loscalzo | Director, Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2022 | 12,000 | 12,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharma Inc | Joseph Loscalzo | Director, Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2022 | 5,333 | 15,108 | - | - | Restricted Stock Unit | |
| Leap Therapeutics Inc | Joseph Loscalzo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2022 | 55,000 | 55,000 | - | - | Stock Option (Right to Buy) |