Monia Brett P.'s most recent trade in Ionis Pharmaceuticals Inc was a trade of 127,500 Common Stock done at an average price of $60.1 . Disclosure was reported to the exchange on Sept. 3, 2025.
| Stock | Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|---|
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 60.13 per share. | 03 Sep 2025 | 127,500 | 180,824 (0%) | 0% | 60.1 | 7,667,047 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.77 per share. | 03 Sep 2025 | 102,900 | 282,909 (0%) | 0% | 53.8 | 5,532,933 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 102,900 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 61.06 per share. | 03 Sep 2025 | 59,699 | 180,009 (0%) | 0% | 61.1 | 3,645,394 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.58 per share. | 03 Sep 2025 | 42,030 | 308,324 (0%) | 0% | 37.6 | 1,579,487 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 42,030 | 76,643 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 31,316 | 67,741 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 03 Sep 2025 | 31,316 | 212,140 (0%) | 0% | 32.6 | 1,020,902 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2025 | 27,568 | 40,173 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 03 Sep 2025 | 27,568 | 239,708 (0%) | 0% | 32.6 | 898,717 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 59.12 per share. | 03 Sep 2025 | 16,615 | 266,294 (0%) | 0% | 59.1 | 982,262 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Other type of transaction at price $ 27.71 per share. | 29 Aug 2025 | 189 | 180,009 (0%) | 0% | 27.7 | 5,237 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 30 Jul 2025 | 2,432 | 182,252 (0%) | 0% | 32.6 | 79,283 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2025 | 2,432 | 99,057 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 30 Jul 2025 | 2,432 | 179,820 (0%) | 0% | 45 | 109,440 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 41.74 per share. | 11 Jul 2025 | 1,160 | 179,820 (0%) | 0% | 41.7 | 48,416 | Common Stock |
| Cognition Therapeutics Inc | Brett P. Monia | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2025 | 34,000 | 48,500 | - | 0 | Common Stock | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 32.32 per share. | 11 Mar 2025 | 140 | 180,980 (0%) | 0% | 32.3 | 4,525 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Other type of transaction at price $ 28.21 per share. | 28 Feb 2025 | 437 | 181,120 (0%) | 0% | 28.2 | 12,328 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 31.65 per share. | 04 Feb 2025 | 38,843 | 180,683 (0%) | 0% | 31.7 | 1,229,463 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2025 | 25,372 | 232,768 (0%) | 0% | 0 | Common Stock | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 32.45 per share. | 30 Jan 2025 | 13,242 | 219,526 (0%) | 0% | 32.4 | 429,655 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 169,950 | 630,201 | - | - | Performance Restricted Stock Units | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 129,395 | 325,607 | - | - | Restricted Stock Unit | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 73,448 | 240,841 (0%) | 0% | 0 | Common Stock | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 73,448 | 252,159 | - | - | Restricted Stock Unit | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 32.63 per share. | 15 Jan 2025 | 33,445 | 207,396 (0%) | 0% | 32.6 | 1,091,444 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 86,263 | 86,263 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 38.05 per share. | 12 Nov 2024 | 6,630 | 167,393 (0%) | 0% | 38.1 | 252,294 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Other type of transaction at price $ 38.64 per share. | 30 Aug 2024 | 140 | 174,023 (0%) | 0% | 38.6 | 5,410 | Common Stock |
| Cognition Therapeutics Inc | Brett P. Monia | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2024 | 8,500 | 8,500 | - | - | Stock Option (right to buy) | |
| Cognition Therapeutics Inc | Brett P. Monia | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2024 | 8,500 | 14,500 | - | 0 | Common Stock | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, CEO Level 15 | Other type of transaction at price $ 34.43 per share. | 29 Feb 2024 | 538 | 174,289 (0%) | 0% | 34.4 | 18,521 | Common Stock |
| Ionis Pharmaceuticals Inc | Monia P. Brett | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 44.49 per share. | 16 Feb 2024 | 387 | 173,751 (0%) | 0% | 44.5 | 17,219 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 49.37 per share. | 02 Feb 2024 | 23,907 | 173,732 (0%) | 0% | 49.4 | 1,180,348 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 49.37 per share. | 02 Feb 2024 | 23,907 | 173,732 (0%) | 0% | 49.4 | 1,180,348 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 25,372 | 177,223 (0%) | 0% | 0 | Common Stock | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 49.37 per share. | 01 Feb 2024 | 23,501 | 174,138 (0%) | 0% | 49.4 | 1,160,303 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 20,416 | 197,639 (0%) | 0% | 0 | Common Stock | |
| Ionis Pharmaceuticals Inc | P. Monia Brett | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 51.75 per share. | 25 Jan 2024 | 2,285 | 151,851 (0%) | 0% | 51.8 | 118,249 | Common Stock |
| Ionis Pharmaceuticals Inc | Monia P. Brett | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 68,084 | 186,195 (0%) | 0% | 0 | Common Stock | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 68,084 | 196,212 | - | - | Restricted Stock Unit | |
| Ionis Pharmaceuticals Inc | P. Monia Brett | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 32,059 | 154,136 (0%) | 0% | 50.4 | 1,616,319 | Common Stock |
| Ionis Pharmaceuticals Inc | Monia P. Brett | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 143,550 | 460,251 | - | - | Performance Restricted Stock Units | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 87,435 | 264,296 | - | - | Restricted Stock Unit | |
| Ionis Pharmaceuticals Inc | Brett Monia P. | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 116,580 | 116,580 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharmaceuticals Inc | P. Monia Brett | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 49.29 per share. | 20 Dec 2023 | 17,500 | 118,111 (0%) | 0% | 49.3 | 862,577 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett Monia P. | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 20 Dec 2023 | 17,500 | 135,611 (0%) | 0% | 47.3 | 828,450 | Common Stock |
| Ionis Pharmaceuticals Inc | P. Brett Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Dec 2023 | 17,500 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharmaceuticals Inc | Monia P. Brett | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Dec 2023 | 6,500 | 17,500 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharmaceuticals Inc | Brett Monia P. | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 20 Dec 2023 | 6,500 | 124,611 (0%) | 0% | 47.3 | 307,710 | Common Stock |
| Ionis Pharmaceuticals Inc | Monia Brett P. | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 49.64 per share. | 20 Dec 2023 | 6,500 | 118,111 (0%) | 0% | 49.6 | 322,643 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 49.21 per share. | 14 Dec 2023 | 14,860 | 118,111 (0%) | 0% | 49.2 | 731,310 | Common Stock |
| Ionis Pharmaceuticals Inc | Monia P. Brett | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2023 | 14,860 | 33,140 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharmaceuticals Inc | P. Brett Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 14 Dec 2023 | 14,860 | 132,971 (0%) | 0% | 47.3 | 703,472 | Common Stock |
| Ionis Pharmaceuticals Inc | Monia Brett P. | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2023 | 9,140 | 24,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharmaceuticals Inc | Monia P. Brett | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 50.19 per share. | 14 Dec 2023 | 9,140 | 118,111 (0%) | 0% | 50.2 | 458,709 | Common Stock |
| Ionis Pharmaceuticals Inc | Monia Brett P. | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 14 Dec 2023 | 9,140 | 127,251 (0%) | 0% | 47.3 | 432,688 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 42.25 per share. | 07 Jul 2023 | 18,650 | 121,724 (0%) | 0% | 42.2 | 787,953 | Common Stock |
| Cognition Therapeutics Inc | Brett P. Monia | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2023 | 6,000 | 6,000 | - | - | Stock Option (right to buy) | |
| Cognition Therapeutics Inc | Brett P. Monia | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2023 | 6,000 | 6,000 | - | 0 | Common Stock | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 40.14 per share. | 22 May 2023 | 2,630 | 140,374 (0%) | 0% | 40.1 | 105,568 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 40.13 per share. | 22 May 2023 | 2,301 | 143,004 (0%) | 0% | 40.1 | 92,339 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2023 | 25,372 | 169,956 (0%) | 0% | 0 | Common Stock | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 40.69 per share. | 03 Feb 2023 | 24,651 | 145,305 (0%) | 0% | 40.7 | 1,003,153 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2023 | 17,210 | 144,584 (0%) | 0% | 0 | Common Stock | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2023 | 6,511 | 127,374 (0%) | 0% | 0 | Common Stock | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 57,267 | 145,929 (0%) | 0% | 0 | Common Stock | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 57,267 | 176,861 | - | - | Restricted Stock Unit | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 39.49 per share. | 17 Jan 2023 | 25,066 | 120,863 (0%) | 0% | 39.5 | 989,947 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 146,128 | 316,701 | - | - | Performance Restricted Stock Units | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 89,005 | 234,128 | - | - | Restricted Stock Unit | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 118,673 | 118,673 | - | - | Non-Qualified Stock Option (right to buy) | |
| Cognition Therapeutics Inc | Brett P. Monia | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2022 | 8,335 | 8,335 | - | - | Stock Option (Right to Buy) | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 37.49 per share. | 01 Apr 2022 | 355 | 88,662 (0%) | 0% | 37.5 | 13,309 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Other type of transaction at price $ 28.37 per share. | 28 Feb 2022 | 621 | 89,017 (0%) | 0% | 28.4 | 17,620 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jan 2022 | 14,004 | 96,428 (0%) | 0% | 0 | Common Stock | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 31.44 per share. | 26 Jan 2022 | 8,032 | 88,396 (0%) | 0% | 31.4 | 252,526 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jan 2022 | 2,194 | 82,424 (0%) | 0% | 0 | Common Stock | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Jan 2022 | 49,475 | 99,944 (0%) | 0% | 0 | Common Stock | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Jan 2022 | 49,475 | 145,123 | - | - | Restricted Stock Unit | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 30.12 per share. | 18 Jan 2022 | 19,714 | 80,230 (0%) | 0% | 30.1 | 593,786 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2022 | 76,117 | 170,573 | - | - | Performance Restricted Stock Units | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2022 | 50,745 | 194,598 | - | - | Restricted Stock Unit | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2022 | 101,489 | 101,489 | - | - | Non-Qualified Stock Option (right to buy) | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Other type of transaction at price $ 33.80 per share. | 31 Aug 2021 | 355 | 50,469 (0%) | 0% | 33.8 | 11,998 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Other type of transaction at price $ 44.54 per share. | 26 Feb 2021 | 247 | 50,350 (0%) | 0% | 44.5 | 11,001 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 54.28 per share. | 26 Feb 2021 | 236 | 50,114 (0%) | 0% | 54.3 | 12,809 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jan 2021 | 2,634 | 51,409 (0%) | 0% | 0 | Common Stock | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 60.69 per share. | 28 Jan 2021 | 1,306 | 50,103 (0%) | 0% | 60.7 | 79,261 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2021 | 77,447 | 77,447 | - | - | Performance Restricted Stock Units | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2021 | 66,610 | 66,610 | - | - | Restricted Stock Units | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2021 | 34,823 | 63,702 (0%) | 0% | 0 | Common Stock | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2021 | 34,823 | 77,243 | - | - | Restricted Stock Units | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 61.28 per share. | 15 Jan 2021 | 14,927 | 48,775 (0%) | 0% | 61.3 | 914,727 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2021 | 149,872 | 149,872 | - | - | Employee Stock Option (right to buy) | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 51.04 per share. | 04 Dec 2020 | 23,840 | 28,879 (0%) | 0% | 51.0 | 1,216,794 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Dec 2020 | 23,840 | 0 | - | - | Employee Stock Option (right to buy) | |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 39.87 per share. | 04 Dec 2020 | 23,840 | 52,719 (0%) | 0% | 39.9 | 950,501 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 39.87 per share. | 02 Dec 2020 | 21,160 | 50,039 (0%) | 0% | 39.9 | 843,649 | Common Stock |
| Ionis Pharmaceuticals Inc | Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Dec 2020 | 21,160 | 23,840 | - | - | Employee Stock Option (right to buy) |